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https://www.readbyqxmd.com/read/29788757/expression-of-nmda-receptor-subunits-in-human-blood-lymphocytes-a-peripheral-biomarker-in-online-computer-game-addiction
#1
Mitra-Sadat Sadat-Shirazi, Nasim Vousooghi, Bentolhoda Alizadeh, Seyed Mohammad Makki, Seyed Zeinolabedin Zarei, Shahrzad Nazari, Mohammad Reza Zarrindast
Background and aims Repeated performance of some behaviors such as playing computer games could result in addiction. The NMDA receptor is critically involved in the development of behavioral and drug addictions. It has been claimed that the expression level of neurotransmitter receptors in the brain may be reflected in peripheral blood lymphocytes (PBLs). Methods Here, using a real-time PCR method, we have investigated the mRNA expression of GluN2A, GluN2D, GluN3A, and GluN3B subunits of the NMDA receptor in PBLs of male online computer game addicts (n = 25) in comparison with normal subjects (n = 26)...
May 23, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29761860/hypermethylation-of-cpg-islands-is-associated-with-increasing-chromosomal-damage-in-chinese-lead-exposed-workers
#2
Li-Bo Yu, Yu-Ting Tu, Jing-Wen Huang, Ya-Nan Zhang, Guo-Qiao Zheng, Xiao-Wen Xu, Jin-Wei Wang, Jean Qin Xiao, David C Christiani, Zhao-Lin Xia
Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppressor genes (TSGs) post lead exposure. In the study, 147 lead-exposed workers were divided into two groups according to their B-Pb P50 value, with other 50 lead-unexposed workers as a control group...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29754417/teaching-paediatric-basic-life-support-in-medical-schools-using-peer-teaching-or-video-demonstration-a-prospective-randomised-trial
#3
Frederik Stephan, Hanjo Groetschel, Anja K Büscher, Deniz Serdar, Kjell A Groes, Rainer Büscher
AIM: The outcome of children with an out-of-hospital cardiac arrest is still poor, but bystander cardiopulmonary resuscitation can increase survival and minimise severe neurological sequelae. While teaching basic life support is standardised in emergency medicine classes, paediatric basic life support (PBLS) in neonates and toddlers is under-represented in paediatric curricula during university education. The appropriate mixture of E-learning and peer teaching lessons remains controversial in teaching paediatric basic skills...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29741731/expression-of-grim-19-in-unexplained-recurrent-spontaneous-abortion-and-possible-pathogenesis
#4
Yang Yang, Laiyang Cheng, Xiaohui Deng, Hongling Yu, Lan Chao
STUDY QUESTION: Is aberrant expression of gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) associated with unexplained recurrent spontaneous abortion (URSA)? SUMMARY ANSWER: GRIM-19 deficiency may regulate regulatory T cell/ T helper 17 cell (Treg/Th17) balance partly through reactive oxygen species (ROS) - mammalian target of rapamycin (mTOR) signaling axis in URSA. WHAT IS KNOWN ALREADY: Immunological disorders may cause impaired maternal immune tolerance to the fetus and result in fetal rejection...
May 8, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29732502/retention-of-knowledge-and-skills-in-pediatric-basic-life-support-amongst-pediatricians
#5
Mathijs Binkhorst, Michelle Coopmans, Jos M T Draaisma, Petra Bot, Marije Hogeveen
Retention of resuscitation skills is usually assessed at a predefined moment, which enables participants to prepare themselves, possibly introducing bias. In this multicenter study, we evaluated the retention of knowledge and skills in pediatric basic life support (PBLS) amongst 58 pediatricians and pediatric residents with an unannounced examination. Practical PBLS skills were assessed with a validated scoring instrument, theoretical knowledge with a 10-item multiple-choice test (MCQ). Participants self-assessed their PBLS capabilities using five-point Likert scales...
May 7, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29708858/how-does-infection-with-human-papillomavirus-16-and-18-impact-on-dna-damage-and-repair-in-cervical-cells-and-peripheral-blood
#6
Eren Ozcagli, Aydan Biri, Bedia Dinc, Semra Sardas
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases worldwide and a prime cause of cervical cancer. The HPV DNA is detected in approximately 80-90% of all cervical cancers, with HPV 16 and 18 being the high risk conferring human carcinogens. DNA damage and diminished DNA repair mechanisms are potential biological surrogates of HPV infection that warrant further research in different tissues and populations. Notably, we do not know the extent to which the high risk HPV 16 and 18 differentially affect cervical cells versus other systems such as peripheral blood lymphocytes (PBLs)...
April 30, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29697193/solid-pseudopapillary-and-malignant-pancreatic-tumors-in-childhood-a-systematic-review-and-evidence-quality-assessment
#7
REVIEW
Konstantinos S Mylonas, Ilias P Doulamis, Diamantis I Tsilimigras, Dimitrios Nasioudis, Dimitrios Schizas, Peter T Masiakos, Cassandra M Kelleher
A systematic review of 32 studies reporting on 489 children with pancreatic tumors was performed. The most prevalent histologic subtype was solid pseudopapillary tumor (SPT) (61.3%). Pancreaticoduodenectomy was the most commonly performed operation (48%). Neoadjuvant chemo/radiotherapy was utilized in 3.9, 36.2, 25, and 27.8% of patients with SPTs, pancreatoblastomas (PBLs), neuroendocrine tumors, and exocrine carcinomas, respectively. Adjuvant chemotherapy (75.6%) and radiation (34%) were most commonly utilized in PBLs...
April 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29684606/sterigmatomyces-halophilus-%C3%AE-glucan-improves-the-immune-response-and-bacterial-resistance-in-pacific-red-snapper-lutjanus-peru-peripheral-blood-leucocytes-in-vitro-study
#8
Martha Reyes-Becerril, Francisco A Guardiola, Veronica Sanchez, Minerva Maldonado, Carlos Angulo
β-Glucans are naturally occurring polysaccharides that are produced by bacteria, fungi and yeast. They are considered immunostimulants in fish acting on non-specific defense mechanism. Yeast-derived glucans from cell wall (Sterigmatomyces halophilus, β-Gluc/Sh) have been used for this purpose in this study. Therefore, an in vitro assay using peripheral blood leucocytes (PBLs) from Pacific red snapper was performed to evaluate the stimulant effects of β-Gluc/Sh and zymosan A (positive control) for 12 and 24 h and after bacterial challenge with Aeromonas hydrophila at 24 h...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684601/the-effect-of-intermittent-hypoxia-under-different-temperature-on-the-immunomodulation-in-streptococcus-agalactiae-vaccinated-nile-tilapia-oreochromis-niloticus
#9
Jing Wang, Dan-Qi Lu, Biao Jiang, Heng-Li Luo, Ge-Ling Lu, An-Xing Li
Dissolved oxygen (DO) and temperature are the potential immunomodulators in fish and play the important roles in regulating immunity. We studied the effect of intermittent hypoxia under different temperature on the immunomodulation in vaccinated Nile tilapia (Oreochromis niloticus). The expression of immune-related genes, enzymatic activities, histology, cumulative mortality, and S. agalactiae clearance were assessed. Study conditions were intermittently hypoxic (4.0 ± 1.0 mg/L DO) at 30 ± 0.5 °C or 35 ± 0...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29673117/mitochondrial-dna-copy-number-is-associated-with-risk-of-head-and-neck-squamous-cell-carcinoma-in-chinese-population
#10
Lihua Wang, Hong Lv, Pei Ji, Xun Zhu, Hua Yuan, Guangfu Jin, Juncheng Dai, Zhibin Hu, Yuxiong Su, Hongxia Ma
Mitochondria show the special role in cellular bioenergy and many essential physiological activities. Previous researches have suggested that variations of mitochondrial DNA copy number contribute to development of different types of carcinomas. However, the relationship of mtDNA copy number in peripheral blood leukocytes (PBLs) with the risk of head and neck squamous cell carcinoma (HNSCC) is still inconclusive. We investigated the association of mtDNA with HNSCC risk through a case-control study including 570 HNSCC cases and 597 cancer-free controls...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29643904/assessment-of-collaborative-problem-solving-skills-in-undergraduate-medical-students-at-ziauddin-college-of-medicine-karachi
#11
Arsalan Manzoor Mughal, Sirajul Haque Shaikh
Objective: Collaborative Problem Solving Empirical Progressions from the Assessment and Teaching of 21st Century Skills (ATC21S) framework were used to determine the level of collaborative problem solving skills (CPS) in first, second and third year MBBS students at Ziauddin College of Medicine during Problem-Based Learning (PBL) sessions. Variations based on gender and roles were studied. Methods: It is an analytical comparative cross-sectional study in which seven PBL groups were selected per year by non-probability convenient sampling...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29628632/expression-of-bax-and-bcl2-genes-in-peripheral-blood-lymphocytes-of-patients-with-differentiated-thyroid-cancer
#12
Zari Hamivand, Gholamhassan Haddadi, Reza Fardid
Context: Thyroid cancer is the most common endocrine malignancy worldwide. Iodine-131 is used in the treatment of thyroid cancer with dosage of 100 mCi. In the medical applications of ionizing radiation besides the advantages such as diagnosis and treatment of diseases, the risks arising from exposure should be considered as well. Aims: The present study aimed to evaluate the changes in expression levels of apoptotic Bax and Bcl-2 and the ratio of Bax/Bcl-2, in the peripheral blood lymphocytes (PBLs) of patients with differentiated thyroid cancer (DTC)...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29626104/activation-of-lysosomal-cathepsins-in-pregnant-bovine-leukocytes
#13
Md Abdus Shabur Talukder, Ahmed Zaky Balboula, Takahiro Shirozu, Sung-Woo Kim, Hiroki Kunii, Toshiyuki Suzuki, Tsukino Ito, Koji Kimura, Masashi Takahashi
In ruminants, interferon-tau (IFNT)-mediated expression of interferon-stimulated genes in peripheral blood leukocytes (PBLs) can indicate pregnancy. Recently, type 1 IFN-mediated activation of lysosomes and lysosomal cathepsins (CTSs) was observed in immune cells. This study investigated the status of lysosomal CTSs and lysosomes in PBLs collected from pregnant (P) and non-pregnant (NP) dairy cows, and conducted in vitro IFNT-stimulation of NP blood leukocytes. Blood samples were collected 0, 7, 14, and 18 days post-artificial insemination, and the peripheral blood mononuclear cells (PBMCs) and polymorphonuclear granulocytes (PMNs) separated...
April 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29604137/immunomodulatory-effect-of-artemisia-argyi-polysaccharide-on-peripheral-blood-leucocyte-of-broiler-chickens
#14
P Zhang, B Shi, T Li, Y Xu, X Jin, X Guo, S Yan
This study was conducted to investigate the immunomodulatory effect of a water-soluble polysaccharide extracted from Artemisia argyi (AAP) in vitro. The effect was assessed in peripheral blood leucocytes (PBLs) of broilers, which were incubated with different AAP concentrations (0, 25, 50, 100, and 200 μg/ml) for 24 hr at 37°C in a 5% CO2 incubator. The results showed that, compared with the control group, immunoglobulin M (IgM) concentration was increased in the supernatant of the 100 μg/ml AAP-treated group (p < ...
March 31, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29604105/xenopus-laevis-macrophage-like-cells-produce-xcl-1-an-intelectin-family-serum-lectin-that-recognizes-bacteria
#15
Saburo Nagata
Xenopus laevis Ca2+ -dependent lectin-1 (XCL-1) is an intelectin family serum lectin that selectively recognizes carbohydrate chains on the bacterial cell surface. Immunofluorescence examination of control spleen tissues from normal X. laevis revealed cells producing XCL-1 (XCL-1+ cells) exclusively in red pulps. Intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS) caused a marked increase in the number of XCL-1+ cells in red pulps on day 3, followed by a rapid decrease to near control levels by day 7...
March 31, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29600983/sensitivity-to-4-hydroxyestradiol-and-dna-repair-efficiency-in-peripheral-blood-lymphocytes-of-endometrial-cancer-patients
#16
L G Buchynska, O V Brieieva
BACKGROUND: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). AIM: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29545645/ligand-triggered-de-repression-of-arabidopsis-heterotrimeric-g-proteins-coupled-to-immune-receptor-kinases
#17
Xiangxiu Liang, Miaomiao Ma, Zhaoyang Zhou, Jinlong Wang, Xinru Yang, Shaofei Rao, Guozhi Bi, Lin Li, Xiaojuan Zhang, Jijie Chai, She Chen, Jian-Min Zhou
Arabidopsis heterotrimeric G proteins regulate diverse processes by coupling to single-transmembrane receptors. One such receptor is the FLS2 receptor kinase, which perceives bacterial flagellin epitope flg22 to activate immunity through a class of cytoplasmic kinases called BIK1/PBLs. Unlike animal and fungal heterotrimeric G proteins that are activated by a ligand-induced guanine nucleotide exchange activity of seven-transmembrane G protein-coupled receptors (GPCRs), plant heterotrimeric G proteins are self-activating...
May 2018: Cell Research
https://www.readbyqxmd.com/read/29459176/variations-of-t-and-b-lymphocytes-of-flounder-paralichthys-olivaceus-after-hirame-novirhabdovirus-infection-and-immunization
#18
Jing Xing, Lei Wang, Mengxiao Zhen, Xiaoqian Tang, Wenbin Zhan
T and B lymphocytes are closely related to immunization and pathogen infection. Our previous study confirmed the CD3+ , CD4-1+ , CD4-2+ , CD8β+ T lymphocytes and IgM+ B lymphocytes presented in the peripheral blood leukocytes (PBLs) of flounder (Paralichthys olivaceus), in this paper, the variations of T and B lymphocytes of flounder after Hirame novirhabdovirus (HIRRV) infection or immunization were investigated. The flounders were injected with live or inactivated HIRRV, then the percentages of T and B lymphocytes in PBLs were analyzed by Flow cytometry (FCM), total antibodies and HIRRV-specific antibodies in serum were detected by Enzyme-linked immunosorbent assay (ELISA), and expression of twelve immune-related genes in the head kidneys were determined using q-PCR...
April 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29447011/the-genotoxic-and-antigenotoxic-potential-of-the-methanolic-root-extract-of-glycyrrhiza-glabra-l-on-human-peripheral-blood-lymphocytes
#19
Ayşe Yavuz Kocaman, Müge Güzelkokar
Glycyrrhiza glabra L. (licorice) is one of the most important medicinal plants, which is widely used throughout the world both in traditional and contemporary medical industries. This study was undertaken to investigate the potential genotoxic activity of G. glabra methanolic root extract, and its possible antigenotoxic properties against mitomycin C (MMC)-induced DNA damage in in vitro chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) assays in human peripheral blood lymphocytes (PBLs)...
February 15, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29444930/immunophenotyping-of-newly-diagnosed-and-recurrent-glioblastoma-defines-distinct-immune-exhaustion-profiles-in-peripheral-and-tumor-infiltrating-lymphocytes
#20
Malte Mohme, Simon Schliffke, Cecile L Maire, Alessandra Rünger, Laura Glau, Klaus C Mende, Jakob Matschke, Christina Gehbauer, Nuray Akyüz, Svenja Zapf, Mareike Holz, Miriam Schaper, Tobias Martens, Nils O Schmidt, Sven Peine, Manfred Westphal, Mascha Binder, Eva Tolosa, Katrin Lamszus
PURPOSE: Immunotherapeutic treatment strategies for glioblastoma (GBM) are under investigation in clinical trials. However, our understanding of the immune phenotype of GBM-infiltrating T-cells (TILs) and changes during disease progression is limited. Deeper insight is urgently needed to therapeutically overcome tumor-induced immune exhaustion. EXPERIMENTAL DESIGN: We used flow-cytometry and cytokine assays to profile TILs and blood lymphocytes (PBL) from GBM patients, comparing newly diagnosed or recurrent GBM to long-term survivors (LTS) and healthy donors...
February 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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