keyword
Keywords Antihypertensive &cognitive im...

Antihypertensive &cognitive impairment

https://read.qxmd.com/read/37682100/-risk-factors-and-adherence-to-treatment-of-patients-with-cerebrovascular-diseases
#21
JOURNAL ARTICLE
L I Pyshkina, A A Tyazhelnikov, A A Kabanov, D T Sherazadishvili, Z H Osmaeva, S V Prikazchikov, P R Kamchatnov
OBJECTIVE: To assess the representation of risk factors and treatment adherence in patients with cerebrovascular diseases. MATERIAL AND METHODS: A single-stage cross-sectional non-comparable study was conducted, which included 492 patients, of whom 133 had an ischemic stroke/transient ischemic attack (main group, MG), 344 had chronic cerebrovascular pathology (comparison group, CG). The representation of risk factors, the state of cognitive functions, the severity of anxiety and depression were evaluated...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37681194/the-use-of-angiotensin-receptor-blockers-in-dementia-prevention
#22
JOURNAL ARTICLE
Jordana de Araujo Müller, Laura Jacques Giacobe, Vanise Grassi, André Luiz Rodrigues Palmeira
UNLABELLED: Alzheimer's disease (AD) and dementia are preventable and highly prevalent diseases, as is systemic arterial hypertension. Thus, it is speculated that angiotensin receptor blockers (ARBs) may be neuroprotective against AD. OBJECTIVE: The aim of this study was to evaluate if the use of ARBs confers a neuroprotective effect on AD, through a systematic review. METHODS: Studies published on Embase, LILACS, SciELO, and PubMed were evaluated...
2023: Dementia & Neuropsychologia
https://read.qxmd.com/read/37603340/changes-in-the-use-of-long-term-medications-following-incident-dementia-diagnosis
#23
JOURNAL ARTICLE
Timothy S Anderson, John Z Ayanian, Vilsa E Curto, Eran Politzer, Jeffrey Souza, Alan M Zaslavsky, Bruce E Landon
IMPORTANCE: Dementia is a life-altering diagnosis that may affect medication safety and goals for chronic disease management. OBJECTIVE: To examine changes in medication use following an incident dementia diagnosis among community-dwelling older adults. DESIGN, SETTING, AND PARTICIPANTS: In this cohort study of adults aged 67 years or older enrolled in traditional Medicare and Medicare Part D, patients with incident dementia diagnosed between January 2012 and December 2018 were matched to control patients based on demographics, geographic location, and baseline medication count...
August 21, 2023: JAMA Internal Medicine
https://read.qxmd.com/read/37544058/effects-of-intensive-blood-pressure-control-on-cognitive-function-in-patients-with-cerebral-small-vessel-disease
#24
JOURNAL ARTICLE
Bingqing Zhao, Weihua Jia, Ye Yuan, Zheng Li, Xinran Fu
OBJECTIVE: This study aimed to investigate the effects of intensive blood pressure control on cognitive function in elderly patients with cerebral small vessel disease (CSVD). METHODS: From May 2020 to June 2022, 140 outpatients and inpatients with CSVD and hypertension in the Department of Neurology of Beijing Shijingshan Hospital were selected. They were randomly divided into the standard and intensive blood pressure control groups, and the dosage of antihypertensive drugs was adjusted to reduce the blood pressure to the target level...
September 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/37443018/identification-of-a-psychiatric-risk-gene-nisch-at-3p21-1-gwas-locus-mediating-dendritic-spine-morphogenesis-and-cognitive-function
#25
JOURNAL ARTICLE
Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao
BACKGROUND: Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously reported that single nucleotide polymorphisms spanning chromosome 3p21.1 showed significant associations with both schizophrenia and BD, and a risk SNP rs2251219 was in linkage disequilibrium with a human specific Alu polymorphism rs71052682, which showed enhancer effects on transcriptional activities using luciferase reporter assays in U251 and U87MG cells...
July 13, 2023: BMC Medicine
https://read.qxmd.com/read/37343515/clinical-trials-in-vascular-cognitive-impairment-following-sprint-mind-an-international-perspective
#26
REVIEW
Fanny M Elahi, Suvarna Alladi, Sandra E Black, Jurgen A H R Claassen, Charles DeCarli, Timothy M Hughes, Justine Moonen, Nicholas M Pajewski, Brittani R Price, Claudia Satizabal, C Elizabeth Shaaban, Nárlon C B S Silva, Heather M Snyder, Lukas Sveikata, Jeff D Williamson, Frank J Wolters, Atticus H Hainsworth
A large interventional trial, the Systolic Blood Pressure Intervention Trial sub-study termed Memory and Cognition in Decreased Hypertension (SPRINT-MIND), found reduced risk of cognitive impairment in older adults with intensive, relative to standard, blood-pressure-lowering targets (systolic BP < 120 vs. <140 mm Hg). In this perspective, we discuss key questions and make recommendations for clinical practice and for clinical trials, following SPRINT-MIND. Future trials should embody cognitive endpoints appropriate to the participant group, ideally with adaptive designs that ensure robust answers for cognitive and cardiovascular endpoints...
June 20, 2023: Cell reports medicine
https://read.qxmd.com/read/37335722/stomach-ulcer-caused-by-mistakenly-oral-medication-of-14-400%C3%A2-mg-ibuprofen-a-case-report
#27
JOURNAL ARTICLE
Zhang Meijuan, Penglong Yu, Jie Yuan, Tao Yu, Dan Sun
RATIONALE: Gastric mucosal ulcer caused by drug overdose is very rare in clinical practice, and here is a case of gastric antral ulcer caused by drug overdose. PATIENT CONCERNS: A 35-year-old housewife from a mountainous region in China took 48 Ibuprofen Sustained-Release capsules (300 mg/capsule) orally at 1 time. Because of severe tingling in the upper abdomen accompanied by a sharp increase in blood pressure, she came to the doctor 48 hours later. DIAGNOSES: Gastric antral ulcer (multiple stage A1), duodenococcitis, chronic nonatrophic gastritis, Helicobacter pylori infection, moderate depression, and cognitive impairment...
May 19, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37272899/medication-misuse-and-overuse-in-community-dwelling-persons-with-dementia
#28
JOURNAL ARTICLE
W James Deardorff, Bocheng Jing, Matthew E Growdon, Kristine Yaffe, W John Boscardin, Kenneth S Boockvar, Michael A Steinman
BACKGROUND: Persons with dementia (PWD) have high rates of polypharmacy. While previous studies have examined specific types of problematic medication use in PWD, we sought to characterize a broad spectrum of medication misuse and overuse among community-dwelling PWD. METHODS: We included community-dwelling adults aged ≥66 in the Health and Retirement Study from 2008 to 2018 linked to Medicare and classified as having dementia using a validated algorithm...
June 5, 2023: Journal of the American Geriatrics Society
https://read.qxmd.com/read/37208478/comparing-the-effects-of-four-common-drug-classes-on-the-progression-of-mild-cognitive-impairment-to-dementia-using-electronic-health-records
#29
JOURNAL ARTICLE
Jie Xu, Fei Wang, Chengxi Zang, Hao Zhang, Kellyann Niotis, Ava L Liberman, Cynthia M Stonnington, Makoto Ishii, Prakash Adekkanattu, Yuan Luo, Chengsheng Mao, Luke V Rasmussen, Zhenxing Xu, Pascal Brandt, Jennifer A Pacheco, Yifan Peng, Guoqian Jiang, Richard Isaacson, Jyotishman Pathak
The objective of this study was to investigate the potential association between the use of four frequently prescribed drug classes, namely antihypertensive drugs, statins, selective serotonin reuptake inhibitors, and proton-pump inhibitors, and the likelihood of disease progression from mild cognitive impairment (MCI) to dementia using electronic health records (EHRs). We conducted a retrospective cohort study using observational EHRs from a cohort of approximately 2 million patients seen at a large, multi-specialty urban academic medical center in New York City, USA between 2008 and 2020 to automatically emulate the randomized controlled trials...
May 19, 2023: Scientific Reports
https://read.qxmd.com/read/37203821/the-complexity-of-basophobia-and-aging-covariates-and-consequences
#30
JOURNAL ARTICLE
P Premalatha, V Krishnaraju, H A Shadia, M H Abuadas, F A Zainab, A E Rasha, E L Sampayan, M A Abeer, A A Hala, K Prabahar, N Harikrishnan, E Vigneshwaran, V Vinoth Prabhu, H Alshareef, H M Manal
OBJECTIVE: The study aim is to determine the drug-induced incidence of basophobia, falls, its' related variables and the consequences among older adults. PATIENTS AND METHODS: A descriptive, cross-sectional study was adopted with 210 older adult samples. The tool consisted of 6 sections: a standardized, semi-structured questionnaire and physical examination. Descriptive and inferential statistics were used to analyze the data. RESULTS: Among the study participants, 49% had falls or near falls and 51% had basophobia in the past 6 months...
May 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37185147/rational-prescribing-and-deprescribing-of-antihypertensive-medications-in-older-people-a-three-part-narrative-review-part-3
#31
JOURNAL ARTICLE
Patrick Russell, Campbell Thompson, Arduino A Mangoni
What happens when you stop? This is the third of a three-part series on antihypertensive medication use in older people. In the first, we reviewed the importance of better blood pressure (BP) control, even in older people with hypertension. In the second, we discussed the limitations of the evidence favoring intensive therapy for some older people. For older people with advanced frailty or those with a limited life expectancy, medications taken for BP can actually be a source of morbidity. Guidelines encourage clinical judgment and rational prescribing...
May 1, 2023: Senior Care Pharmacist
https://read.qxmd.com/read/37131908/antihypertensive-therapy-is-associated-with-improved-visuospatial-executive-attention-abstraction-memory-and-recall-scores-on-the-montreal-cognitive-assessment-in-geriatric-hypertensive-patients
#32
JOURNAL ARTICLE
Suhrud Panchawagh, Yogita Karandikar, Shripad Pujari
BACKGROUND: The prevalence of Mild Cognitive Impairment (MCI) has increased over the past few decades. However, it can potentially be reversed if detected early. Early detection of MCI using the sensitive Montreal Cognitive Assessment (MoCA) might prove to be an important cog in the wheel in identifying and slowing down this morbid pandemic in hypertensive persons. OBJECTIVES: To study the association of antihypertensive agents on cognitive scores and prevalence of MCI using the MoCA...
2023: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/37125762/dynamic-cerebral-autoregulation-in-alzheimer-s-disease-and-mild-cognitive-impairment-a-systematic-review
#33
REVIEW
Rachel Heutz, Jurgen Claassen, Sanne Feiner, Aaron Davies, Dewakar Gurung, Ronney B Panerai, Rianne de Heus, Lucy C Beishon
Dynamic cerebral autoregulation (dCA) is a key mechanism that regulates cerebral blood flow (CBF) in response to transient changes in blood pressure (BP). Impairment of dCA could increase vulnerability to hypertensive vascular damage, but also to BP lowering effects of antihypertensive treatment. The literature remains conflicted on whether dCA is altered in Alzheimer's disease (AD) and mild cognitive impairment (MCI). We summarized available data on dCA in AD and MCI, by searching PubMed, Embase, PsycINFO and Web of Science databases (inception-January 2022)...
May 1, 2023: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/37090575/associations-of-antihypertensive-medication-consumption-and-drug-drug-interaction-with-statin-and-metformin-with-reduced-alzheimer-s-disease-and-related-dementias-risk-among-hypertensive-patients-with-mild-cognitive-impairment-using-high-volume-claims-data
#34
Cui Tao, Sori Lundin, Xinyue Hu, Jingna Feng, Karl Lundin, Yong Chen
Background: While hypertension is a modifiable risk factor of Alzheimer's disease and related dementias (ADRD), limited studies have been conducted on the effectiveness of antihypertensive medications (AHMs) in altering the progression from mild cognitive impairment (MCI) to ADRD; similarly, few studies have assessed drug-drug interactions of AHMs with drugs targeted to modify other risk factors of ADRD such as type Ⅱ diabetes and hypercholesterolemia. Method: 128,683 unique hypertensive patients with MCI on US-based Optum claims data were identified...
April 13, 2023: Research Square
https://read.qxmd.com/read/37072268/the-impact-of-uncontrolled-hypertension-on-the-cns
#35
JOURNAL ARTICLE
Aleš Tomek
The brain is a target of organ damage due to hypertension. In addition to acute damage in the form of hypertensive encephalopathy, ischaemic stroke, and intracerebral haemorrhage, hypertension causes chronic changes in the brain tissue that, over the course of years, will be manifested by impaired brain functions including cognitive deficit. Hypertension is also a risk factor for progression of cognitive disorder to overt dementia. It is commonly accepted that the earlier in life hypertension occurs, the greater the risk of developing dementia in old age...
2023: Vnitr̆ní Lékar̆ství
https://read.qxmd.com/read/37032819/association-between-behavioral-and-psychological-symptoms-and-cerebral-small-vessel-disease-mri-findings-in-memory-clinic-patients
#36
JOURNAL ARTICLE
Masaki Shinohara, Kana Matsuda, Yuichiro Ii, Ken-Ichi Tabei, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Maeda, Hidekazu Tomimoto, Akihiro Shindo
OBJECTIVES: Cerebral small vessel disease (SVD) is commonly observed among elderly individuals with cognitive impairment and has been recognized as a vascular contributor to dementia and behavioral and psychological symptoms (BPS), however, the relationship between BPS and SVD burden remains unclear. METHODS: We prospectively recruited 42 patients with mild cognitive impairment (MCI) or mild dementia from the memory clinic in our hospital, who were assigned to either a clinical dementia rating (CDR) of 0...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37021189/the-effects-of-amlodipine-and-other-blood-pressure-lowering-agents-on-microvascular-function-in-small-vessel-diseases-treat-svds-trial-study-protocol-for-a-randomised-crossover-trial
#37
JOURNAL ARTICLE
Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair Js Webb, Joanna M Wardlaw, Martin Dichgans
BACKGROUND: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs. AIMS: To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when compared to atenolol in patients with symptomatic SVDs. DESIGN: TREAT-SVDs is an investigator-led, prospective, open-label, randomised crossover trial with blinded endpoint assessment (PROBE design) conducted at five study sites across Europe...
March 2023: European Stroke Journal
https://read.qxmd.com/read/36859481/effect-of-long-term-antihypertensive-treatment-on-cerebrovascular-structure-and-function-in-hypertensive-rats
#38
JOURNAL ARTICLE
Daphne M P Naessens, Judith de Vos, Edo Richard, Micha M M Wilhelmus, Cornelis A M Jongenelen, Edwin R Scholl, Nicole N van der Wel, Johannes A Heijst, Charlotte E Teunissen, Gustav J Strijkers, Bram F Coolen, Ed VanBavel, Erik N T P Bakker
Midlife hypertension is an important risk factor for cognitive impairment and dementia, including Alzheimer's disease. We investigated the effects of long-term treatment with two classes of antihypertensive drugs to determine whether diverging mechanisms of blood pressure lowering impact the brain differently. Spontaneously hypertensive rats (SHR) were either left untreated or treated with a calcium channel blocker (amlodipine) or beta blocker (atenolol) until one year of age. The normotensive Wistar Kyoto rat (WKY) was used as a reference group...
March 1, 2023: Scientific Reports
https://read.qxmd.com/read/36827394/orthostatic-hypotension-and-neurocognitive-disorders-in-older-women-results-from-the-epidos-cohort-study
#39
JOURNAL ARTICLE
Guillaume T Duval, Anne-Marie Schott, Yves Rolland, Jennifer Gautier, Hubert Blain, Gustavo Duque, Cedric Annweiler
BACKGROUND: Although it is well-admitted that cardiovascular health affects cognition, the association between orthostatic hypotension (OH) and cognition remains unclear. The objectives of the present study were i) to determine among the EPIDOS cohort (EPIdémiologie de l'OStéoporose) whether OH was cross-sectionally associated with cognitive impairment at baseline, and ii) whether baseline OH could predict incident cognitive decline after 7 years of follow-up. METHODS: Systolic and Diastolic Blood Pressure (SBP and DBP) changes while standing (ie, ΔSBP and ΔDBP, in %) were measured at baseline among 2,715 community-dwelling older women aged 75 years and older using no antihypertensive drugs from the French EPIDOS cohort...
2023: PloS One
https://read.qxmd.com/read/36716007/effects-of-a-polypill-aspirin-and-the-combination-of-both-on-cognitive-and-functional-outcomes-a-randomized-clinical-trial
#40
RANDOMIZED CONTROLLED TRIAL
Jacqueline J Bosch, Martin J O'Donnell, Peggy Gao, Philip Joseph, Prem Pais, Denis Xavier, Antonio Dans, Patricio Lopez Jaramillo, Salim Yusuf
IMPORTANCE: Vascular risk factors are associated with cognitive decline but studies addressing individual risk factors have not demonstrated an effect of risk factor management on the preservation of cognition. Few trials have examined the effect of vascular risk factor management on function. OBJECTIVE: To determine if a polypill could reduce cognitive and functional decline in people with risk factors but without manifest cardiovascular disease. DESIGN, SETTING, AND PARTICIPANTS: The International Polycap Study 3 (TIPS-3) was a 2 × 2 × 2 factorial randomized clinical trial...
March 1, 2023: JAMA Neurology
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