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Diabetis mellitus

Bhagyashri Ramachandra Latti, Jitendra V Kalburge, Sanjeev Bhimashankar Birajdar, Ramachandra Girimallappa Latti
Background: Diabetes mellitus is a metabolic disease leading to abnormal fat, carbohydrate and protein metabolism. Reduced salivary flow rate caused by hyperglycemia is characteristic mainly for periods of poor metabolic control of diabetes, thereby facilitating the growth of aciduric bacteria and caries-lesion development. The objective of our study was to evaluate the effects of diabetes mellitus on dental caries micro-organisms responsible for caries. Materials and Methods: This study was carried out on 60 subjects consisting of 2 groups...
May 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Anca Chiriac, Irina Costache, Cristian Podoleanu, Adrian Naznean, Simona Stolnicu
Bullosis diabeticorum (BD), or diabetic bulla, is 1 of the cutaneous manifestations of diabetes mellitus, reported in 0.5% of people with diabeties in the United States, mostly in adult men who have had long-lasting and uncontrolled diabetes associated with diabetic peripheral neuropathy. However, BD in young children is a mostly unrecognized entity. We present a case of BD in a 3-year-old girl with type 1 diabetes mellitus who had been treated with insulin for 7 months prior to hospitalization. Dermatologic examination revealed a large, tense bulla filled with clear fluid and not associated with pain or pruritus, localized on the lateral margin of the right hand...
April 2017: Canadian Journal of Diabetes
Mara Graziele Maciel Silveira, Antônio Carlos Sobral Sousa, Marcos Antônio Almeida Santos, Irlaneide da Silva Tavares, Stephanie Macedo Andrade, Luiza Dantas Melo, Loren Suyane Oliveira de Andrade, Emmanuel Lima Almeida Santos, Joselina Luzia Menezes Oliveira
BACKGROUND: Physical stress echocardiography is an established methodology for diagnosis and risk stratification of coronary artery disease in patients with physical capacity. In obese (body mass index ≥ 30 kg/m2) the usefulness of pharmacological stress echocardiography has been demonstrated; however, has not been reported the use of physical stress echocardiography in this growing population group. OBJECTIVE: To assess the frequency of myocardial ischemia in obese and non-obese patients undergoing physical stress echocardiography and compare their clinical and echocardiographic differences...
May 2015: Arquivos Brasileiros de Cardiologia
I K Quaye, L A Brakohiakpa, G A Amoah, N Ayi-Ankrah, Y Kido
Glycemic indices have been used to predict useful carbohydrate sources of food for patients with non-insulin-dependent diabeties mellitus (NIDDM) on dietary management programs. The present study has revealed that glycemic indices alone are not adequate predictors of useful carbohydrate meal sources. We observed for the first time that glycemic indexes inversely correlate with triglyceride indices. In our test mixed meals varying in five Ghanaian carbohydrate food types for nine non-insulin dependent diabetics, the correlation between glycemic and triglyceride indices was (r = -0...
March 1999: Asia Pacific Journal of Clinical Nutrition
Paula Cristina Anibal, Janaina de Cássia Orlandi Sardi, Iza Teixeira Alves Peixoto, Julianna Joanna de Carvalho Moraes, José Francisco Höfling
Candida-associated denture stomatitis is the most common form of oral candidal infection, with Candida albicans being the principal etiological agent. Candida adheres directly or via an intermediary layer of plaque-forming bacteria to denture acrylic. Despite antifungal therapy to treat denture stomatitis, infection is reestablished soon after the treatment ceases. In addition, many predisposing factors have been identified as important in the development of oral candidiasis, including malnourishment, common endocrine disorders, such as diabetis mellitus, antibacterial drug therapy, corticosteroids, radiotherapy and other immunocompromised conditions, such as acquired immunodeficiency syndrome (AIDS)...
October 2010: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Hanan Munitz
Clozapine has been in use since 1975. It was withdrawn due to its toxic effects on granulocytes. It was reintroduced due to its positive effect on schizophrenia in patients who did not respond to two antipsychotic drugs. These patients suffer from a chronic debilitating disease, with numerous and sometimes chronic hospitalizations. Clozapine also has antiaggression and antisuicide effects, as well as specific effects on the negative symptoms of schizophrenia. There are severe side effects that may appear. These include suppression of granulocytes, cardiotoxic effect on the myocard, as well as cardiac conduction defects...
May 2012: Harefuah
Abiola O Oladapo, Jamie C Barner, Karen L Rascati, Scott A Strassels
BACKGROUND: Adherence to oral antidiabetic (OAD) medications is essential in achieving glycemic control and slowing the progression of diabeties-related complications such as neuropathic pain. OAD medication adherence has been suboptimal and adding neuropathic pain medications may negatively affect adherence. However, little is known about adherence to neuropathic pain medications by patients with diabetes and how this may be related to OAD medication adherence. OBJECTIVE: The objectives of our study were to: (1) describe painful diabetic peripheral neuropathy (PDPN) and OAD medication use, (2) determine if PDPN medication adherence differs among individual PDPN medications (ie, tricyclic antidepressants, gabapentin, pregabalin, and duloxetine); and (3) determine if PDPN medication adherence is related to post-index OAD medication adherence while controlling for covariates...
March 2012: Clinical Therapeutics
M Mata-Cases, P Roura-Olmeda, M Berengué-Iglesias, M Birulés-Pons, X Mundet-Tuduri, J Franch-Nadal, B Benito-Badorrey, J F Cano-Pérez
AIMS: To assess the evolution of type 2 diabetes mellitus (T2DM) quality indicators in primary care centers (PCC) as part of the Group for the Study of Diabetes in Primary Care (GEDAPS) Continuous Quality Improvement (GCQI) programme in Catalonia. METHODS: Sequential cross-sectional studies were performed during 1993-2007. Process and outcome indicators in random samples of patients from each centre were collected. The results of each evaluation were returned to each centre to encourage the implementation of correcting interventions...
March 2012: International Journal of Clinical Practice
Omar Soliman El Safoury, Magdy Ibrahim
BACKGROUND: Skin tags (STs) have been investigated as a marker of type 2 diabetes mellitus (DM), yet the relation of STs to obesity is still a matter of controversy. AIM: The aim of the study is to explore the relation of number, size and color of STs to obesity, diabetes, sex and age in one study. METHODS: The study included 245 nondiabetic (123 males and 122 females) and 276 diabetic (122 males and 154 females) subjects. We recorded age, sex, body mass index (BMI), relevant habits, STs color, size, and number in different anatomical sites...
July 2011: Indian Journal of Dermatology
A Mafundikwa, C E Ndhlovu, Zar Gomo
OBJECTIVE: The objective of this study was to determine the prevalence of diabetic nephropathy in a diabetic clinic in a tertiary hospital setting in Zimbabwe. DESIGN: Descriptive cross sectional study. SETTING: Diabetic clinic in a tertiary hospital. SUBJECTS: 75 insulin dependent diabetic consenting adults aged over 18 years. METHODS: Consecutive sampling of 75 insulin dependent consenting subjects presenting at the Parirenyatwa Diabetic Clinic was conducted over a four month period...
January 2007: Central African Journal of Medicine
Atul Kumar, Ram Awatar Maurya, Siddharth Sharma, Pervez Ahmad, A B Singh, A K Tamrakar, Arvind K Srivastava
We have designed 1,3-disubstituted-5-membered heteroaromatic ring system as a common core motif from known anti-hyperglycemic agents. Designed compounds were synthesized and screened for in vivo anti-hyperglycemic activity in sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) as well as db/db mice model. Some of the synthesized compounds showed promising in vivo anti-hyperglycemic as well as moderate lipid lowering activity. Synthesized Compounds were screened in various in vitro models of type-2 diabeties such as DPP-4, PTP1B and PPARgamma to know the mechanism of their anti-hyperglycemic action...
July 15, 2009: Bioorganic & Medicinal Chemistry
Angélica Gobbi Jorge, Carolina Maria Módulo, Ana Carolina Dias, Alexandre Martins Braz, Rubens Bertazolli Filho, Alceu A Jordão, Jayter Silva de Paula, Eduardo Melani Rocha
The aim of this study is to evaluate whether aspirin reduces Diabetis Mellitus (DM) oxidative damage in the lacrimal gland (LG), and ocular surface (OS). Ten weeks after streptozotocin induced DM and aspirin treatment, LG and OS of rats were compared for tear secretion, hidtology, peroxidase activity, and expression of uncoupling proteins (UCPs). DM reduction of tear secretion was prevented by aspirin (P < 0.01). Alterations of LG morphology and increased numbers of lipofucsin-like inclusions were observed in diabetic but not in aspirin-treated diabetic rats...
April 2009: Endocrine
Samia A El-Dardiry, Sherine R Shafik, Ayman Wagih, El-Amir M Amir, Gamal K Kassem, Ghada Atef, Heba El-Toukhy
Forty five smokers were classified into schistosomal cases with type-2 diabetis mellitus (GI) and with associated history of bronchial asthma (GII) and without T-2 DM (GIII). A control group (GIV) of non-diabetic non schistosomal age matched subjects who quitted smoking for >6 months were included. Assessed parameters included indices of glycemic status (glycated hemoglobin), angiogenesis (vascular endothelial growth factor) hepatic and bronchoalveolar disposition (Liver function test, metallothionein, serum levels of cotinine, cadmium selenium, copper & zinc) and bronchoalveolar lavage) (BAL) levels of surfactant proteins A & D, zinc and copper oxidative stress and fibrogenesis (total antioxidant capacity thiobarbituric acid reactive substance) and vasculopathy (angiotensin converting enzyme, P-selectin, nitrate) and periodontitis (collagenase and elastase in GCF) impact of cigarette smoking associated with trace element disbalance and enzymatic changes in crevicular fluid on altered parameters collaborative out-come...
August 2007: Journal of the Egyptian Society of Parasitology
S A Al-Shammari, T A Khoja, M A Al-Maatouq
Attendees of 15 health centers in urban and rural areas in the Riyadh region were screened for obesity during May and June 1994. Systemic selection yielded 1580 Saudi males for analysis. The mean age was 33.6 +/- 13.5 years and body mass index (BMI) was 26.9 +/- 5.7 kg/m(2). Only 36.6% of subjects were their ideal weight (BMI < 25 kg/m(2)), while 34.8% were overweight (BMI 25-29.9 kg/m(2)), 26.9% were moderately obese (BMI 30-40 kg/m(2)) and 1.7% were morbidly obese (BMI > 40 kg/m(2)). Middle age, lower education and joblessness predicted a higher risk for obesity...
May 1996: Annals of Saudi Medicine
Atsushi Yoshinaga, Tetsuo Hayashi, Soichiro Yoshida, Rena Ohno, Nobuyuki Ishii, Toshiya Terao, Toru Watanabe, Takumi Yamada
We compared the prevalence of concurrent diseases (diabetes mellitus, hypertension, ischemic heart diseases and apoplexy) in patients with renal cell carcinoma, bladder carcinoma and prostatic carcinoma diagnosed in our department with that in all patients in our department analyzed using Mantel-Haenszel regression. In hypertension, there was a significantly high prevalence of patients with renal cell carcinoma (p < 0.05) in males and females, and prostatic carcinoma (p < 0.05). In diabetis mellitus, ischemic heart diseases and apoplexy, no apparent characteristic of prevalence was recognized...
July 2006: Hinyokika Kiyo. Acta Urologica Japonica
Sergio Mezzano, Claudio Aros, Alejandra Droguett, M Eugenia Burgos, Leopoldo Ardiles, Claudio Flores, Herman Schneider, Marta Ruiz-Ortega, Jesús Egido
BACKGROUND: Nuclear factor-kappaB (NF-kappaB) regulates genes involved in renal disease progression, such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES. NF-kappaB is activated in experimental models of renal injury, and in vitro studies also suggest that proteinuria and angiotensin II could be important NF-kappaB activators. It has been proposed that locally produced MCP-1 may be involved in the development of diabetic nephropathy (DN). We examined the hypothesis that NF-kappaB could be an indicator of renal damage progression in DN...
October 2004: Nephrology, Dialysis, Transplantation
Sarkis B Baghdasarian, Hani Jneid, Byron J Hoogwerf
BACKGROUND: Statins have mechanisms of action that expand their effects beyond cholesterol lowering and atherosclerotic medical conditions. OBJECTIVE: This review summarizes clinical evidence for the association of dyslipidemia and the effects of statin use on aortic stenosis, Alzheimer's dementia (AD), osteoporosis, prevention of diabetes mellitus (DM), diabetic retinopathy, age-related macular degeneration, and diabetic/nondiabetic nephropathy. METHODS: An English-language literature search was conducted using MEDLINE (1966-June 2003)...
March 2004: Clinical Therapeutics
M B Gomes, S H Castro, T Garfinkel, L M Fernandes, E F Cunha, V I Lobão
OBJECTIVE: To evaluate glycemic control in type 1 diabetes mellitus patients followed in 1998. PATIENTS AND METHODS: We studied 38 patients [22 males; age = 10.4 -/+ 4.1 years; 12 (31.6%) prepubertal, 26 (68.4%) pubertal], with diabetes duration of 3.7-/+3.4 years and age of diagnosis of 7.2 -/+ 4.7 years. HbA1c was determined using high-performance liquid chromatography (L-9100 Merck Hitachi, reference value =2.6 to 6.2%). RESULTS: HbA1c was 8.04 -/+ 2.4%, without association with gender and puberty. In the 27 patients with at least two HbA1c determinations, the level of glycemic control changed in 8 (29...
January 2001: Jornal de Pediatria
M M Leclercq, O Bonidan, E Haaby, C Pierrejean, J Sengler
OBJECTIVES: Osteopenia in lower extremity amputation is described with an increased risk of fracture and it seems to be interesting to study bone mass in a population of 99 amputees of limb. MATERIAL AND METHOD: We studied the bone mass with Dual Energy Xray Absorptiometry in patients with limb amputation, above and under knee and who have been treated in the rehabilitation department of Mulhouse's hospital and more specifically the percentage of the difference of the mesure between amputed and non amputed side and the influence on this mesure of several factors like sexe; age; diabetes mellitus; delay of amputation; aetiology and use of prosthesis...
February 2003: Annales de Réadaptation et de Médecine Physique
Thungchanbemo Ezung, Ng Taruni Devi, N Tombi Singh, Th Biren Singh
One hundred diabetes mellitus patients attending the diabetic clinic and those admitted in the medical wards of the Regional Institute of Medical Sciences, Imphal, were selected randomly to study the prevalence of pulmonary tuberculosis with the age-and the sexwise distribution in diabetes mellitus patients. The diagnosis of diabetes mellitus was established from the dinical symptoms and the estimation of blood sugar levels whereas pulmonary tuberculosis was diagnosed from clinical, radiological and bacteriological examinations...
June 2002: Journal of the Indian Medical Association
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