Zekang Su, Yali Zhang, Shiyi Hong, Qiaojian Zhang, Zhiqiang Ji, Guiping Hu, Xiaojun Zhu, Fang Yuan, Shanfa Yu, Tianchen Wang, Li Wang, Guang Jia
Exposure to hexavalent chromium damages genetic materials like DNA and chromosomes, further elevating cancer risk, yet research rarely focuses on related immunological mechanisms, which play an important role in the occurrence and development of cancer. We investigated the association between blood chromium (Cr) levels and genetic damage biomarkers as well as the immune regulatory mechanism involved, such as costimulatory molecules, in 120 workers exposed to chromates. Higher blood Cr levels were linearly correlated with higher genetic damage, reflected by urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and blood micronucleus frequency (MNF)...
April 17, 2024: Environmental Science & Technology