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stenotrophomonas maltophilia in childrens

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https://www.readbyqxmd.com/read/26139084/characteristics-of-stenotrophomonas-maltophilia-bacteremia-in-children
#1
Munehiro Furuichi, Kenta Ito, Isao Miyairi
BACKGROUND: Empiric antimicrobial coverage in compromised hosts commonly includes pseudomonal coverage but often lacks coverage against Stenotrophomonas maltophilia. Identification of risk factors specific for S. maltophilia infection may lead to prompt initiation of appropriate antibiotics and improved outcome. METHODS: We conducted a retrospective analysis of pediatric patients with bacteremia due to S. maltophilia or Pseudomonas aeruginosa from April 2002 to July 2014 at a tertiary children's hospital...
February 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26061914/risk-factors-for-lung-function-decline-in-a-large-cohort-of-young-cystic-fibrosis-patients
#2
MULTICENTER STUDY
Jonathan Cogen, Julia Emerson, Don B Sanders, Clement Ren, Michael S Schechter, Ronald L Gibson, Wayne Morgan, Margaret Rosenfeld
OBJECTIVE: To identify novel risk factors and corroborate previously identified risk factors for mean annual decline in FEV1% predicted in a large, contemporary, United States cohort of young cystic fibrosis (CF) patients. METHODS: Retrospective observational study of participants in the EPIC Observational Study, who were Pseudomonas-negative and ≤12 years of age at enrollment in 2004-2006. The associations between potential demographic, clinical, and environmental risk factors evaluated during the baseline year and subsequent mean annual decline in FEV1 percent predicted were evaluated using generalized estimating equations...
August 2015: Pediatric Pulmonology
https://www.readbyqxmd.com/read/25830929/development-and-validation-of-an-hplc-uv-assay-to-quantify-plasma-levels-of-sulfametrol-a-preferential-antibiotic-in-children
#3
Birgit C P Koch, Sabina R Zabirova, Bart C H van der Nagel, Lidwien M Hanff
BACKGROUND: Sulfonamides in combination with trimethoprim are frequently used antibiotics. They work synergistic. In infections with Pneumocystis jiroveci or Stenotrophomonas maltophilia, higher dosages are indicated than in other infections. Therapeutic drug monitoring (TDM) is warranted to assure the efficacy while limiting toxicity. Although trimethoprim in combination with sulfamethoxazole is the most common combination with established TDM target concentrations, the intravenous formulation is not suited for children because of its additives ethanol and propylene glycol to increase solubility...
October 2015: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/25704257/diagnosing-ventilator-associated-pneumonia-in-pediatric-intensive-care
#4
Elias Iosifidis, Stella Stabouli, Anastasia Tsolaki, Vaios Sigounas, Emilia-Barbara Panagiotidou, Maria Sdougka, Emmanuel Roilides
The Centers for Disease Control and Prevention's criteria were applied by independent investigators for ventilator-associated pneumonia (VAP) diagnosis in critically ill children and compared with tracheal aspirate cultures (TACs). In addition, correlation between antibiotic use, VAP incidence, and epidemiology of TACs was investigated. A modest agreement (κ = 0.41) was found on radiologic findings between 2 investigators. VAP incidence was 7.7 episodes per 1,000 ventilator days, but positive TACs were the most significant factor for driving high antimicrobial usage in the pediatric intensive care unit...
April 1, 2015: American Journal of Infection Control
https://www.readbyqxmd.com/read/25565628/sputum-induction-improves-detection-of-pathogens-in-children-with-cystic-fibrosis
#5
Jordana E Hoppe, Elinor Towler, Brandie D Wagner, Frank J Accurso, Scott D Sagel, Edith T Zemanick
BACKGROUND: Sputum induction is a safe, well tolerated means of obtaining lower airway secretions from children with cystic fibrosis (CF), particularly for assessment of airway inflammation but the clinical value in diagnosing outpatient infections has not been extensively studied. OBJECTIVES: Investigate the success rate and microbiologic yield of induced sputum (IS) compared to oropharyngeal swabs (OP) and expectorated sputum (ES) samples in children with CF, and determine if IS culture results impact treatment...
July 2015: Pediatric Pulmonology
https://www.readbyqxmd.com/read/25383937/antibiotic-strategies-for-eradicating-pseudomonas-aeruginosa-in-people-with-cystic-fibrosis
#6
REVIEW
Simon C Langton Hewer, Alan R Smyth
BACKGROUND: Respiratory tract infection with Pseudomonas aeruginosa occurs in most people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortality and morbidity. Early infection may be easier to eradicate.This is an update of a Cochrane review first published in 2003, and previously updated in 2006 and 2009. OBJECTIVES: To determine whether antibiotic treatment of early Pseudomonas aeruginosa infection in children and adults with cystic fibrosis eradicates the organism, delays the onset of chronic infection, and results in clinical improvement...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25293429/stenotrophomonas-maltophilia-infection-among-young-children-in-a-cardiac-intensive-care-unit-a-single-institution-experience
#7
Ciji Arthur, Xinyu Tang, Jose R Romero, Jeffrey G Gossett, Nada Harik, Parthak Prodhan
Stenotrophomonas maltophilia can present as bacteremia, respiratory tract infection, urinary tract infection, soft tissue and wound infections, bone and joint infections, meningitis, and endocarditis especially in immunosuppressed patients and those with underlying medical conditions. The incidence and impact of S. maltophilia in young children with heart disease are poorly defined. A single center retrospective observational study was conducted in infants <180 days of age with positive S. maltophilia cultures over a period of 5 years...
March 2015: Pediatric Cardiology
https://www.readbyqxmd.com/read/25140768/-pathogenic-analysis-of-ventilator-associated-pneumonia-in-the-pediatric-intensive-care-unit-in-high-altitude-areas
#8
Yan-Liang Xia, Mei Ge, Zhen Wang
OBJECTIVE: To investigate the pathogens of ventilator-associated pneumonia (VAP) and their drug resistance in the pediatric intensive care unit (PICU) in high-altitude areas and to provide a clinical basis for the prevention and treatment of VAP. METHODS: A total of 94 children with VAP hospitalized in the PICU in high-altitude areas between June 2011 and June 2013 were recruited. Their lower respiratory tract secretions were collected for bacterial culture and drug sensitivity test...
August 2014: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/24980571/maldi-tof-a-useful-tool-for-laboratory-identification-of-uncommon-glucose-non-fermenting-gram-negative-bacteria-associated-with-cystic-fibrosis
#9
Helena Aguilar Peres Homem de Mello de Souza, Libera Maria Dalla-Costa, Fernando José Vicenzi, Dilair Camargo de Souza, Carlos Antônio Riedi, Nelson Augusto Rosario Filho, Marcelo Pilonetto
The predisposition of patients with cystic fibrosis (CF) for recurrent pulmonary infections can result in poor prognosis of the disease. Although the clinical significance in CF of micro-organisms, such as Staphylococcus aureus, Haemophilus influenzae and Pseudomonas aeruginosa, is well established, the implication of uncommon glucose non-fermenting Gram-negative bacilli (UGNF-GNB) in respiratory samples from CF patients is still unclear. Because of limitations of traditional methods used in most clinical laboratories, the accurate identification of these microbes is a challenge...
September 2014: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/24644274/clinical-outcomes-after-initial-pseudomonas-acquisition-in-cystic-fibrosis
#10
MULTICENTER STUDY
Edith T Zemanick, Julia Emerson, Valeria Thompson, Sharon McNamara, Wayne Morgan, Ronald L Gibson, Margaret Rosenfeld
OBJECTIVES: To evaluate clinical outcomes associated with initial isolation of Pseudomonas aeruginosa (Pa) in a large U.S. cystic fibrosis (CF) cohort in the current era of widespread early Pa eradication therapy. METHODS: Participants were children with CF enrolled in the Early Pseudomonas Infection Control (EPIC) Observational Study who had no isolation of Pa from respiratory cultures prior to enrollment. Population-averaged regression models using generalized estimating equation methods were used to estimate the effect of Pa acquisition on endpoints including lung function, growth, pulmonary exacerbation rate, respiratory signs and symptoms, and respiratory cultures...
January 2015: Pediatric Pulmonology
https://www.readbyqxmd.com/read/24502062/the-impact-of-respiratory-tract-infections-on-the-nutritional-state-of-children-with-cystic-fibrosis
#11
Laura Mihaela Trandafir, Mihaela Moscalu, Georgeta Diaconu, E Cîrdeiu, Alexandra Ana Maria Tudose, Gabriela Coman, Dana Teodora Anton Păduraru
UNLABELLED: Cystic fibrosis (CF) is a life-shortening, autosomal-recessive disorder characterized by intestinal malabsorption, impaired growth and lung disease. Recurrent pulmonary infections in children with CF are often associated with nutritional deficiencies. AIM: To emphasize the effects of recurrent pulmonary infections on nutritional status in children with CF. MATERIAL AND METHODS: This retrospective study included 27 patients diagnosed with CF between 1994 and 2011 in the 3rd Pediatric Clinic of the Iasi "Saint Mary" Children's Hospital...
October 2013: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/24418473/predictors-and-outcome-of-low-initial-forced-expiratory-volume-in-1-second-measurement-in-children-with-cystic-fibrosis
#12
COMPARATIVE STUDY
Gulnur Com, John L Carroll, Maria Melguizo Castro, Xinyu Tang, Supriya Jambhekar, Ariel Berlinski
OBJECTIVE: To identify the characteristics of children with cystic fibrosis with low initial forced expiratory volume in 1 second (FEV1) % predicted and to investigate their outcome. STUDY DESIGN: Patients were categorized into low or high initial FEV1 groups using cluster analysis. Comparisons of the demographic and clinical data were performed between the 2 groups. RESULTS: From 122 children, 21 clustered into the low and 101 into the high FEV1 group...
April 2014: Journal of Pediatrics
https://www.readbyqxmd.com/read/24346607/the-use-of-colistin-in-critically-ill-children-in-a-pediatric-intensive-care-unit
#13
Adem Karbuz, Halil Özdemir, Ayhan Yaman, Bilge Aldemir Kocabaş, Çağlar Odek, Haluk Güriz, Ahmet Derya Aysev, Ergin Çiftçi, Tanil Kendirli, Can Ateş, Erdal İnce
BACKGROUND: Colistin is active against most multidrug-resistant, aerobic Gram-negative bacteria. Because of the reported nephrotoxicity during the first years of use of colistin, there were concerns of its use in pediatrics where there was limited experience The aim of this study is to document the clinical characteristics and outcomes of use of colistin in pediatric patients at a pediatric intensive care unit in Turkey. METHODS: We reviewed the medical and laboratory records of 29 critically ill children who were treated with colistin for 38 courses between January 2011 and December 2011 at the Department of Pediatric Intensive Care Unit in Ankara University Medical School, Turkey...
January 2014: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/23806622/induced-sputum-compared-to-bronchoalveolar-lavage-in-young-non-expectorating-cystic-fibrosis-children
#14
COMPARATIVE STUDY
Hannah Blau, Barry Linnane, Rosemary Carzino, Esta-Lee Tannenbaum, Billy Skoric, Philip J Robinson, Colin Robertson, Sarath C Ranganathan
BACKGROUND: Induced sputum (IS) is feasible and safe in young CF children and is a readily accessible, non-invasive technique. However, it has not been compared to bronchoalveolar lavage (BAL), the gold standard for diagnosing lower airway infection. METHODS: We compared bacterial yield from IS and BAL in 11 non-expectorating CF children, aged 3 to 7.4 years. IS samples were obtained in 10/11 cases. RESULTS: Eight out of ten had the same predominant bacteria cultured from IS and BAL: Pseudomonas aeruginosa and Stenotrophomonas maltophilia[1], Staphylococcus aureus[3], and upper respiratory tract flora [4]...
January 2014: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/23757360/factors-influencing-the-acquisition-of-stenotrophomonas-maltophilia-infection-in-cystic-fibrosis-patients
#15
Sanja Stanojevic, Felix Ratjen, Derek Stephens, Annie Lu, Yvonne Yau, Elizabeth Tullis, Valerie Waters
BACKGROUND: Stenotrophomonas maltophilia is one of the most common multi-drug resistant organisms causing pulmonary infections in CF patients. It is unknown whether S. maltophilia infection follows the same pattern and shares similar risk factors for acquisition as described for Pseudomonas aeruginosa. METHODS: We examined all clinical events from 1997 to 2008 in the Toronto CF Database to identify risk factors for the acquisition of S. maltophilia and to define distinct patterns of infection...
December 2013: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/23560788/-bacterial-isolates-from-respiratory-samples-of-pediatric-patients-with-cystic-fibrosis-and-their-distribution-by-ages
#16
Natalia P Busquets, María R Baroni, María C Ochoteco, María L Zurbriggen, Stella Virgolini, Fernando G Meneghetti
The bacterial isolates from respiratory samples of 50 pediatric patients with cystic fibrosis, their distribution by ages and antimicrobial resistance pattern as well as the intermittence of isolations and coinfections, were investigated. Staphylococcus aureus was isolated in 72 % of patients, followed by Pseudomonas aeruginosa (58 %), Haemophilus. influenzae (56 %), and the Burkholderia cepacia complex (12 %). The frequency of resistance of P. aeruginosa isolates to β-lactam antibiotics was low (13.8 %). Fifty percent of S...
January 2013: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/23397905/stenotrophomonas-mycobacterium-and-streptomyces-in-home-dust-and-air-associations-with-moldiness-and-other-home-family-characteristics
#17
E Kettleson, S Kumar, T Reponen, S Vesper, D Méheust, S A Grinshpun, A Adhikari
Respiratory illnesses have been linked to children's exposures to water-damaged homes. Therefore, understanding the microbiome in water-damaged homes is critical to preventing these illnesses. Few studies have quantified bacterial contamination, especially specific species, in water-damaged homes. We collected air and dust samples in twenty-one low-mold homes and twenty-one high-mold homes. The concentrations of three bacteria/genera, Stenotrophomonas maltophilia, Streptomyces sp., and Mycobacterium sp., were measured in air and dust samples using quantitative PCR (QPCR)...
October 2013: Indoor Air
https://www.readbyqxmd.com/read/23294530/chronic-stenotrophomonas-maltophilia-infection-and-mortality-or-lung-transplantation-in-cystic-fibrosis-patients
#18
Valerie Waters, Eshetu G Atenafu, Annie Lu, Yvonne Yau, Elizabeth Tullis, Felix Ratjen
BACKGROUND: Chronic Stenotrophomonas maltophilia infection is an independent risk factor for severe pulmonary exacerbations in cystic fibrosis (CF) patients. The goal of this study was to determine the effect of chronic S. maltophilia infection on mortality and the need for lung transplantation in a longitudinal study of children and adults with CF. METHODS: This was a cohort study of CF patients from the Hospital for Sick Children and St Michael's Hospital (Toronto, Canada) from 1997 to 2008...
September 2013: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/23251300/pathogenic-analysis-of-sputum-from-ventilator-associated-pneumonia-in-a-pediatric-intensive-care-unit
#19
Bo-Tao Ning, Chen-Mei Zhang, Tao Liu, Sheng Ye, Zi-Hao Yang, Zhen-Jie Chen
Ventilator-associated pneumonia (VAP) is a common and sometimes fatal complication in pediatric intensive care units (PICU). The aim of our study was to characterize the distribution and drug susceptibility of the pathogens isolated from the sputum of patients with VAP in the PICU of our hospital and to provide support to the administration of antibiotics early and reasonably in the clinic. Our study was conducted between January 2007 and December 2011 at the PICU of the Children's Hospital of Zhejiang University School of Medicine...
January 2013: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/23113657/antimicrobial-susceptibility-and-combination-testing-of-invasive-stenotrophomonas-maltophilia-isolates
#20
Deirdre Church, Tracie Lloyd, Gisele Peirano, Johann Pitout
BACKGROUND: Treatment of invasive Stenotrophomonas maltophilia infections is difficult due to this organism's inherent multidrug resistance and increasing resistance to trimethoprim-sulfamethoxazole via acquisition of the sul genes. METHODS: In vitro antibiotic susceptibility testing was performed using a customized broth microdilution panel. Combination testing for tigecycline with anti-Stenotrophomonas agents (i.e. colistin, ticarcillin-clavulanate, ceftazidime, and levofloxacin) was done using the cross Etest method...
April 2013: Scandinavian Journal of Infectious Diseases
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