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https://www.readbyqxmd.com/read/29663398/transition-of-the-programmed-death-1-pathway-from-the-primary-colorectal-cancer-to-its-corresponding-pulmonary-metastasis
#1
Ei Miyamoto, Toyofumi F Chen-Yoshikawa, Chiyuki Ueshima, Akihiko Yoshizawa, Masatsugu Hamaji, Takamasa Yamamoto, Kenji Kawada, Hironori Haga, Yoshiharu Sakai, Hiroshi Date
BACKGROUND AND OBJECTIVES: The inhibition of the programmed death 1 (PD-1)/its ligand 1 (PD-L1) pathway may be associated with clinical responses in colorectal cancer (CRC). We aimed to characterize the transition of PD-1/PD-L1 expression through pulmonary metastasis (PM) and its clinical relevance. METHODS: This study retrospectively reviewed 50 patients who had curative resection of primary CRC and its PM. We evaluated the presence of PD-1+ tumor-infiltrating lymphocytes (TILs) and PD-L1+ tumor cells in both the primary tumor and its PM by immunohistochemistry...
April 17, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29661726/detection-of-synchronous-primary-lung-adenocarcinomas-with-genomic-sequencing
#2
Debra Berry, Mani Mahadevan, Mark R Wick
In the setting of synchronous pulmonary carcinomas, distinguishing between a monoclonal process with intrapulmonary metastasis and two independent tumors has significant therapeutic and prognostic implications. We describe two cases in which molecular profiling was used to characterize synchronous, primary pulmonary tumors and guide clinical management. In both cases, the patients underwent surgical resection without adjuvant chemotherapy or radiation and remain free of disease.
January 11, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29659391/pediatric-patient-with-cerebral-metastasis-from-papillary-thyroid-cancer
#3
Katrina Korhonen, Hongming Zhuang
Brain metastasis from papillary thyroid carcinoma is uncommon. Concurrent cerebral and pulmonary metastases from papillary thyroid carcinoma is rare, especially in pediatric patients. We report a case of a brain metastasis revealed on post-therapy I scan in a 12 year old girl with thyroid cancer who also had diffuse pulmonary metastases which were partially responsive to sequential I therapy.
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29659181/combination-of-anginex-gene-therapy-and-radiation-decelerates-the-growth-and-pulmonary-metastasis-of-human-osteosarcoma-xenografts
#4
Kai Zhao, Shang-You Yang, Jun Geng, Xuan Gong, Weiming Gong, Lin Shen, Bin Ning
Investigate whether rAAV-anginex gene therapy combined with radiotherapy could decrease growth and pulmonary metastasis of osteosarcoma in mice and examine the mechanisms involved in this therapeutic strategy. During in vitro experiment, multiple treatment regimes (rAAV-eGFP, radiotherapy, rAAV-anginex, combination therapy) were applied to determine effects on proliferation of endothelial cells (ECs) and G-292 osteosarcoma cells. During in vivo analysis, the same multiple treatment regimes were applied to osteosarcoma tumor-bearing mice...
April 16, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29658333/mucinous-breast-carcinoma-with-tall-columnar-cells
#5
N Tsoukalas, M Kiakou, M Tolia, I D Kostakis, M Galanopoulos, G Nakos, D Tryfonopoulos, G Kyrgias, G Koumakis
Mucinous carcinoma of the breast represents 1%-4% of all breast cancers. The World Health Organization classification divides this type of tumour into three different subtypes: mucinous carcinoma, mucinous carcinoma with tall columnar cells (mucinous cystadenocarcinoma and columnar cell mucinous carcinoma) and signet ring cell carcinoma. A 74-year-old woman presented a tumour with inflammatory features in the upper outer quadrant of her left breast, 7 cm in diameter. The core biopsy showed infiltrating ductal carcinoma of no specific type...
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29655462/obesity-thrombotic-risk-and-inflammation-in-cancer
#6
Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E García-Luna, María G Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A Reyes, Arnulfo H Nava-Zavala
Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29650821/-continuation-of-axitinib-for-advanced-renal-cell-carcinoma-by-the-application-of-homecare-urology-a-case-report-and-literature-review
#7
Satoshi Yazawa, Yuji Kato, Jin Nakahara, Toshio Miyata, Mototsugu Oya
A 56-year-old man with advanced RCC and a past medical history of type 2 diabetes underwent a radical left nephrectomy following a histological diagnosis of papillary RCC, G2, INF b, pT3, V1 in 1999. In 2008, sorafenib was started to treat multiple pulmonary metastases of RCC. In 2011, sorafenib was switched to sunitinib when radiologic progression was observed. In 2014, sunitinib was switched to axitinib when further radiologic progression was observed. In 2015, the patient was referred to Yazawa clinic for homecare urology when hospital visits became difficult due to cancer pain and bilateral lower-extremity muscle weakness...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650315/radiomics-based-features-for-pattern-recognition-of-lung-cancer-histopathology-and-metastases
#8
José Raniery Ferreira Junior, Marcel Koenigkam-Santos, Federico Enrique Garcia Cipriano, Alexandre Todorovic Fabro, Paulo Mazzoncini de Azevedo-Marques
BACKGROUND AND OBJECTIVES: lung cancer is the leading cause of cancer-related deaths in the world, and its poor prognosis varies markedly according to tumor staging. Computed tomography (CT) is the imaging modality of choice for lung cancer evaluation, being used for diagnosis and clinical staging. Besides tumor stage, other features, like histopathological subtype, can also add prognostic information. In this work, radiomics-based CT features were used to predict lung cancer histopathology and metastases using machine learning models...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29649906/knockdown-of-lncrna-malat1-contributes-to-the-suppression-of-inflammatory-responses-by-up-regulating-mir-146a-in-lps-induced-acute-lung-injury
#9
Lingling Dai, Guojun Zhang, Zhe Cheng, Xi Wang, Liuqun Jia, Xiaogang Jing, Huan Wang, Rui Zhang, Meng Liu, Tianci Jiang, Yuanjian Yang, Meng Yang
BACKGROUND: Acute lung injury (ALI) is a type of severe pulmonary inflammatory disease with high rates of morbidity and mortality. Now, an increasing number of studies suggest that lncRNAs may act as key regulators of the inflammatory response and play a crucial role in the pathogenesis of many inflammatory diseases. Our study firstly explored the function and underlying mechanism of lncRNA metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) in regulating the inflammatory response of lipopolysaccharide (LPS)-induced ALI in rats...
April 13, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#10
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29629977/clinicopathologic-features-and-genetic-alterations-of-a-primary-osteosarcoma-of-the-uterine-corpus
#11
Gang Zheng, Abby Richmond, Chengbao Liu, Alexander Berrebi, Aparna Pallavajjala, Lisa Haley, Rebecca L Stone, Edward McCarthy, Russell Vang, Deyin Xing
Primary osteosarcoma (OS) of the uterus is distinctly rare. We report a case of primary uterine OS with pulmonary metastasis in a 74-yr-old woman. Histopathologic features of the uterine tumor were in keeping with a pure chondroblastic OS composed of neoplastic cells with osteoblastic/chondroblastic differentiation and neoplastic bone formation. Despite treatment with Doxorubicin and Olaratumab and later with palliative radiation therapy, the patient died 7 mo after hysterectomy due to multiple distant metastases...
April 6, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29627404/development-of-spray-freeze-dried-sirna-pei-powder-for-inhalation-with-high-aerosol-performance-and-strong-pulmonary-gene-silencing-activity
#12
Tomoyuki Okuda, Masaki Morishita, Kimiyasu Mizutani, Ayumi Shibayama, Maki Okazaki, Hirokazu Okamoto
In the present study, a novel dry small interfering RNA (siRNA) powder for inhalation, containing polyethyleneimine (PEI) as a delivery vector, was produced by spray freeze drying (SFD). The powder had spherical and highly porous structure of approximately 10 μm in diameter with high aerosol performance for emission and lung delivery. The reconstituted siRNA/PEI complex after dissolution of the powder had almost the same physicochemical properties and in vitro gene silencing activity as the original one constituted in the sample solution before SFD, showing that the integrity of the siRNA was maintained...
April 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29627084/one-lung-flooding-enables-ultrasound-guided-transthoracic-needle-biopsy-of-pulmonary-nodules-with-high-sensitivity
#13
Thomas Günter Lesser, Iver Petersen, Frank Pölzing, Frank Wolfram
Ultrasound-guided transthoracic needle biopsy (USgTTNB) can only be used for peripheral tumours that contact the pleura. Sonographic accessibility of the entire lung can be achieved using one-lung flooding. In this study, feasibility, sensitivity and complication rate of USgTTNB of lung nodules after one-lung flooding in an ex vivo and in vivo lung tumour model were assessed. USgTTNB was performed ex vivo after one-lung flooding in 10 resected human lung lobes containing carcinoma or metastasis. USgTTNB after one-lung flooding and simulation of a lung nodule was conducted in vivo in 5 animals...
April 4, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29625801/alveolar-soft-part-sarcoma-clinical-presentation-treatment-and-outcome-in-a-series-of-13-patients
#14
Yu-Kuan Lin, Po-Kuei Wu, Cheng-Fong Chen, Chao-Ming Chen, Shang-Wen Tsia, Paul Chih-Hsueh Chen, Wei-Ming Chen
BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor that typically affects young patients. Similar to other soft tissue sarcomas, it has high pulmonary metastasis ability, whereas compared with other soft tissue sarcomas, it has high brain metastasis ability. Because of the rarity of the disease, most studies on ASPS have been case reports and small series studies. METHOD: We performed a retrospective study to evaluate the clinical and pathological features and oncological results in a consecutive series of patients with localized or metastatic ASPS treated at our institute between 1994 and 2014...
April 3, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29625247/added-value-of-50-gene-panel-sequencing-to-distinguish-multiple-primary-lung-cancers-from-pulmonary-metastases-a-systematic-investigation
#15
Paul Roepman, Alexandra Ten Heuvel, Karen C Scheidel, Tobias Sprong, Danielle A M Heideman, Cees A Seldenrijk, Gerarda J M Herder, J Alain Kummer
Differentiation between multiple primary lung cancers or pulmonary metastases has important implications for staging, prognosis, and treatment strategies. Clinical and immuno-histopathological criteria have been standardized; however, a substantial number of cases remain difficult to classify. Using next-generation sequencing it is now possible to improve classification of multiple lung cancer lesions. This study systematically investigated the value of routine morphological and immunohistochemical characteristics, p53 protein expression, TP53 mutation analysis, and 50-gene panel sequencing on 111 lesions from 50 patients with multiple lung lesions...
April 3, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29623728/poorly-differentiated-chordomas-showing-loss-of-ini1-smarcb1-a-report-of-2-rare-cases-with-diagnostic-implications
#16
Bharat Rekhi, Kemal Kosemehmetoglu, Swapnil Rane, Figen Soylemezoglu, Elif Bulut
Poorly differentiated chordomas are rare musculoskeletal tumors. Case 1. A 42-year-old lady presented with quadriparesis of 2 months' duration. Radiologic imaging disclosed a soft tissue mass in her left prevertebral- and paravertebral cervical region. Case 2. A 4-year-old male child presented with neck pain and restricted head movements of 1-year duration. Radiologic imaging revealed a contrast enhancing, paraspinal soft tissue mass in his cervical region. Microscopic examination in both the cases revealed a cellular malignant tumor composed of moderate to markedly pleomorphic cells with interspersed mitotic figures, along with focal myxoid change and necrosis...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29620679/diagnostic-accuracy-of-18f-fdg-pet-ct-in-the-staging-and-assessment-of-response-to-chemotherapy-in-children-with-ewing-sarcoma
#17
Antonio Ruggiero, Valerio Lanni, Alberto Librizzi, Palma Maurizi, Giorgio Attinà, Stefano Mastrangelo, Alessandro Giordano, Riccardo Riccardi
INTRODUCTION: The purpose of this study was to evaluate the potential role of fluorine-18 fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET-CT) in the staging and assessment of chemotherapy response in Ewing sarcoma. MATERIALS AND METHODS: For 13 patients with Ewing sarcoma, whole-body FDG PET-CT was assessed for site of primary disease, disease extent, and response to therapy. Chest CT, localized magnetic resonance imaging or CT of primary site, and bone scintigrams were evaluated for imaging features of the primary lesion and presence or absence of metastatic disease...
April 3, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29620211/morc2-a-novel-oncogene-is-upregulated-in-liver-cancer-and-contributes-to-proliferation-metastasis-and-chemoresistance
#18
Zhihong Pan, Qianshan Ding, Qian Guo, Yong Guo, Lianlian Wu, Lu Wu, Meng Tang, Honggang Yu, Fuxiang Zhou
Microrchidia 2 (MORC2) is important in DNA damage repair and lipogenesis, however, the clinical and functional role of MORC2 in liver cancer remains to be fully elucidated. The aim the present study was to clarify the role of MORC2 in liver cancer. Expression profile analysis, immunohistochemical staining, reverse transcription-quantitative polymerase chain reaction analysis and western blot analysis were performed to evaluate the levels of MORC2 in liver cancer patient specimens and cell lines; subsequently the expression of MORC2 was suppressed or increased in liver cancer cells and the effects of MORC2 on the cancerous transformation of liver cancer cells were examined in vitro and in vivo...
March 27, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29618868/alveolar-soft-part-sarcoma-of-the-forearm
#19
B Asokan, P Ramanan, M Sundararaj, E Kovarthini
Alveolar soft part sarcoma (ASPS) is a rare form of soft-tissue sarcoma arising from connective tissue. It is most often seen in adolescents and young adults and has high propensity for recurrence and metastasis. Clinically, it mimics haemangioma or arteriovenous malformations. In our case report, an 18-year-old female presented with markedly vascular tumour in the left forearm, for which excision biopsy was done. Histopathological report revealed ASPS. The patient was screened for metastasis. Ultrasound abdomen, computed tomography (CT) chest, CT brain and whole-body skeletal survey was done...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29608407/epitope-mapping-of-monoclonal-antibody-pmab-48-against-dog-podoplanin
#20
Shinji Yamada, Mika K Kaneko, Shunsuke Itai, Yao-Wen Chang, Takuro Nakamura, Miyuki Yanaka, Satoshi Ogasawara, Takeshi Murata, Hiroaki Uchida, Hideaki Tahara, Hiroyuki Harada, Yukinari Kato
Podoplanin (PDPN), a type I transmembrane sialoglycoprotein, is expressed on normal renal podocytes, pulmonary type I alveolar cells, and lymphatic endothelial cells. Increased expression of PDPN in cancers is associated with poor prognosis and hematogenous metastasis through interactions with C-type lectin-like receptor 2 (CLEC-2) on platelets. We previously reported a novel PMab-48 antibody, which is an anti-dog PDPN (dPDPN) monoclonal antibody (mAb) recognizing PDPN expressed in lymphatic endothelial cells...
April 2, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
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