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https://www.readbyqxmd.com/read/29042417/restoration-of-natural-killer-cell-anti-metastatic-activity-by-il-12-and-checkpoint-blockade
#1
Isabel Ohs, Laura Ducimetiere, Joana Marinho, Paulina Kulig, Burkhard Becher, Sonia Tugues
Immune checkpoint therapies target tumor antigen-specific T cells, but less is known about their effects on natural killer (NK) cells, which help control metastasis. In studying the development of lung metastases, we found that NK cells lose their cytotoxic capacity and acquire a molecular signature defined by the expression of co-inhibitory receptors. In an effort to overcome this suppressive mechanism, we evaluated NK cell responses to the immunostimulatory cytokine IL-12. Exposure to IL-12 rescued the cytotoxicity of NK cells but also led to the emergence of an immature NK cell population which expressed high levels of the co-inhibitory molecules PD-1, Lag-3 and TIGIT, thereby limiting NK cell-mediated control of pulmonary metastases...
October 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/29039690/unilateral-pulmonary-artery-pre-operative-occlusion-test-technical-feasibility-and-safety-prior-to-pneumonectomy-or-pleuropneumonectomy-for-malignancy
#2
Masashi Shimohira, Takuya Hashizume, Kengo Ohta, Kazushi Suzuki, Motoo Nakagawa, Yoshiyuki Ozawa, Katsuhiro Okuda, Satoru Moriyama, Ryoichi Nakanishi, Yuta Shibamoto
OBJECTIVE: The aim of the present study was to assess the technical feasibility and safety of the unilateral pulmonary artery occlusion (UPAO) test in preoperative evaluation of pneumonectomy or pleuropneumonectomy for lung or pleural tumours. MATERIALS AND METHODS: The UPAO test was performed on 91 patients who were scheduled to undergo or were being considered for pneumonectomy or pleuropneumonectomy between June 2003 and July 2016. There were 74 males and 17 females, with a median age of 65 years (range, 23-80)...
October 17, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29037039/synthesis-and-preclinical-evaluation-of-18f-peg3-fpn-for-the-detection-of-metastatic-pigmented-melanoma
#3
Xiaodong Xu, Lujie Yuan, Lianglan Yin, Yaqun Jiang, Yongkang Gai, Qingyao Liu, Yichun Wang, Yongxue Zhang, Xiaoli Lan
Although 18F-5-fluoro-N-(2-[diethylamino]ethyl)picolinamide (18F-5-FPN) is considered a promising radiopharmaceutical for PET imaging of melanoma, it accumulates at high concentrations in the liver. The aim in this research was to optimize the structure of 18F-5-FPN with triethylene glycol to reduce liver uptake as well as improve pharmacokinetics, and to evaluate its performance in detection of melanoma liver and lung metastases. 18F-PEG3-FPN was successfully prepared with a high radiolabeling yield (44.68% ± 5...
October 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29032404/dietary-supplementation-with-methylseleninic-acid-inhibits-mammary-tumorigenesis-and-metastasis-in-male-mmtv-pymt-mice
#4
Sneha Sundaram, Lin Yan
Male breast cancer, which makes up approximately 1% of all breast cancers, is an aggressive disease with poor prognosis. We investigated the effects of dietary supplementation with selenium in the form of methylseleninic acid [(MSeA) 2.5 mg selenium/kg] on mammary tumorigenesis in male MMTV-PyMT mice. The mammary tumor latency was 14.6 weeks for the MSeA-fed group and 13.8 weeks for the controls fed the AIN93G diet (p < 0.05). Dietary supplementation with MSeA, versus the control, resulted in a 72% reduction in tumor progression, a 46% reduction in both final volume and weight of mammary tumors, and a 70% reduction in the number of lung metastases...
October 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29030639/androgen-receptor-increases-hematogenous-metastasis-yet-decreases-lymphatic-metastasis-of-renal-cell-carcinoma
#5
Qingbo Huang, Yin Sun, Xin Ma, Yu Gao, Xintao Li, Yuanjie Niu, Xu Zhang, Chawnshang Chang
Clear cell renal cell carcinoma (ccRCC) is a gender-biased tumor. Here we report that there is also a gender difference between pulmonary metastasis and lymph node metastasis showing that the androgen receptor (AR)-positive ccRCC may prefer to metastasize to lung rather than to lymph nodes. A higher AR expression increases ccRCC hematogenous metastasis yet decreases ccRCC lymphatic metastases. Mechanism dissection indicates that AR enhances miR-185-5p expression via binding to the androgen response elements located on the promoter of miR-185-5p, which suppresses VEGF-C expression via binding to its 3' UTR...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29025252/solitary-breast-metastasis-from-oestrogen-receptor-positive-pulmonary-adenocarcinoma-report-of-a-case-with-a-potential-pitfall
#6
Gábor Cserni
Solitary breast metastases are rare and mimic primary breast carcinoma. A 60-year-old female with a history of pulmonary adenocarcinoma presented with a solitary left breast lump suspicious for malignancy on breast imaging. Core-needle biopsy disclosed an adenocarcinoma strongly and diffusely positive for oestrogen receptors. Further immunohistochemistry was consistent with the breast tumour being a solitary metastasis of her pulmonary cancer. Clinicians and pathologists should be aware of the fact that pulmonary adenocarcinomas may sometimes display strong rather than only focal positivity for oestrogen receptors by immunohistochemistry and may mimic breast cancer of no special type...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29017679/pulmonary-papillary-adenoma-report-of-two-cases
#7
Xin Li Wang, Gui Jin Jiang, Xue Zhu Zhang, Liang Ming Chu, Ying Cao
Pulmonary papillary adenoma is a rare tumor. Two cases without any clinical symptoms were enrolled in our hospital. Both cases were incidentally detected in pulmonary area by imaging. Pathological examination revealed well-circumscribed nodules consisting of papillary growth of cuboidal to low columnar epithelial cells lining the surface of the fibrovascular stroma. Immunohistochemistry (IHC) staining showed that the lining cells were diffusely positive for TTF-1, CK, p63, CK7, and Napsin A. The Ki-67 proliferation index was approximately 2%...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28989054/nuclear-met-promotes-hepatocellular-carcinoma-tumorigenesis-and-metastasis-by-upregulation-of-tak1-and-activation-of-nf-%C3%AE%C2%BAb-pathway
#8
Sze Keong Tey, Edith Yuk Ting Tse, Xiaowen Mao, Frankie Chi Fat Ko, Alice Sze Tsai Wong, Regina Cheuk-Lam Lo, Irene Oi-Lin Ng, Judy Wai Ping Yam
Presence of Met receptor tyrosine kinase in the nucleus of cells has been reported. However, the functions of Met which expresses in the nucleus (nMet) remain elusive. In this study, we found that nMet was increased in 89% of HCC tumorous tissues when compared with the corresponding non-tumorous liver tissues. nMet expression increased progressively along HCC development and significantly correlated with cirrhosis, poorer cellular differentiation, venous invasion, late stage HCC and poorer overall survival...
October 6, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28988111/pai-1-pias3-stat3-mir-34a-forms-a-positive-feedback-loop-to-promote-emt-mediated-metastasis-through-stat3-signaling-in-non-small-cell-lung-cancer
#9
Xian Lin, Bing-Wen Lin, Xiao-Li Chen, Bei-Lei Zhang, Xiong-Jian Xiao, Jing-Shi Shi, Jian-Dong Lin, Xiao Chen
AIM: This study intented to clarify the intracellular effect of PAI-1 on Non-small cell lung cancer (NSCLC) metastasis and the precise mechanism involved. METHODS: The metastatic properties of NSCLC cells were determined by transwell assays and wound-healing assay in vitro. The mRNA and protein expressions of genes were analyzed by Real-time qPCR and western blot, respectively. Pulmonary metastasis model of NSCLC cells was established to evaluate the pro-metastasis effect of PAI-1 and anti-metastatic effect of miR-34a in vivo...
October 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28987561/therapeutic-significance-and-indications-of-pulmonary-metastasectomy-for-hepatocellular-carcinoma-following-liver-resection
#10
Zhigang Hu, Wenbin Li, Pinbo Huang, Zhenyu Zhou, Junyao Xu, Kang Xu, Jie Wang, Heyun Zhang
BACKGROUND: To explore the therapeutic significance and indications of pulmonary metastasectomy (PMT) in hepatocellular carcinoma (HCC) patients with pulmonary metastasis (PM) following liver resection (LR). PATIENTS AND METHODS: PM-HCC patients who underwent LR were retrospectively enrolled, and survival outcomes and prognostic factors were analyzed. Patients were divided into PMT and non-PMT group, and propensity score matching (PSM) analysis was used for survival comparison...
October 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28983707/clinical-and-radiological-discrimination-of-solitary-pulmonary-lesions-in-colorectal-cancer-patients
#11
Yoichi Ohtaki, Kimihiro Shimizu, Toshiteru Nagashima, Seshiru Nakazawa, Kai Obayashi, Yoko Azuma, Misaki Iijima, Takayuki Kosaka, Toshiki Yajima, Hiroomi Ogawa, Soichi Tsutsumi, Motohiro Arai, Akira Mogi, Hiroyuki Kuwano
OBJECTIVES: The lung is one of the most common organs of metastasis from colorectal cancer (CRC), and we have encountered lung cancer patients with a history of CRC. There have been few studies regarding methods used to discriminate between primary lung cancer (PLC) and pulmonary metastasis from CRC (PM-CRC) based only on preoperative findings. We retrospectively investigated predictive factors discriminating between these lesions in patients with a history of CRC. METHODS: Between 2006 and 2015, 117 patients with a history of CRC (44 patients with 47 PLC and 73 patients with 102 PM-CRC) underwent subsequent or concurrent resection of pulmonary lesions...
October 5, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28982872/surgical-treatment-for-pulmonary-metastasis-of-pancreatic-ductal-adenocarcinoma-study-of-12-cases
#12
Motoaki Yasukawa, Takeshi Kawaguchi, Norikazu Kawai, Takashi Tojo, Shigeki Taniguchi
BACKGROUND/AIM: Few studies have reported results with pulmonary metastasectomy for pancreatic ductal adenocarcinoma (PDAC), probably because of their extremely poor outcomes. The aim of this study was to review our institutional experience and analyze the outcomes of pulmonary metastasectomy for PDAC. PATIENTS AND METHODS: A retrospective case-control study of patients undergoing pulmonary metastasectomy for isolated lung metastasis of PDAC between 2004 and 2016...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28979814/breast-cancer-pulmonary-metastasis-is-increased-in-mice-undertaking-spontaneous-physical-training-in-the-running-wheel-a-call-for-revising-beneficial-effects-of-exercise-on-cancer-progression
#13
Marta Smeda, Kamil Przyborowski, Bartosz Proniewski, Agnieszka Zakrzewska, Dawid Kaczor, Marta Stojak, Elzbieta Buczek, Zenon Nieckarz, Jerzy A Zoladz, Joanna Wietrzyk, Stefan Chlopicki
It has been repeatedly shown that regular aerobic exercise exerts beneficial effects on incidence and progression of cancer. However, the data regarding effects of exercise on metastatic dissemination remain conflicting. Therefore, in the present study the possible preventive effects of voluntary wheel running on primary tumor growth and metastases formation in the model of spontaneous pulmonary metastasis were analyzed after orthotopic injection of 4T1 breast cancer cells into mammary fat pads of female Balb/C mice...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28975027/second-lung-malignancy-and-richter-syndrome-in-chronic-lymphocytic-leukemia-case-report-and-literature-review
#14
Ghassen Soussi, Selsabil Daboussi, Samira Mhamdi, Zied Moatemri, Hela Ghedira, Chiraz Aichaouia, Mohsen Khadhraoui, Faouzi El Mezni, Rezaik Cheikh
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative disease. Transformation into Richter disease and occurrence of second malignancies involving the lungs are rare complications. The hallmarks of any thoracic involvement are still unknown. CASE PRESENTATION: We report a case of a 56-year-old male patient, with history of tobacco smoking, who presented with recurrent hemoptysis, fatigue and weight loss. Physical examination was normal except a slightly enlarged supraclavicular lymph node...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28969898/unplanned-procedures-during-thoracoscopic-segmentectomies
#15
Dominique Gossot, Jon Andri Lutz, Madalina Grigoroiu, Emmanuel Brian, Agathe Seguin-Givelet
BACKGROUND: Thoracoscopic sublobar resections (TSLRs) are gaining popularity, but are challenging. However, despite technical difficulties, the reported rate of adverse events, complications, and unplanned procedures is low. To understand this paradox, we have studied our series of TSLRs. METHODS: We reviewed our prospective and intention-to-treat database on videothoracoscopic anatomical resections and extracted all planned thoracoscopic segmentectomies from January 2007 to July 2016...
September 29, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28969184/a-rare-case-of-pulmonary-lymphangitic-carcinomatosis-in-a-young-adult-with-carcinoma-stomach
#16
Prasanta Kumar Bhattacharya, Md Jamil, Yookarin Khonglah, Aakash Roy, Murti V Subrahmanya
Pulmonary Lymphangitic Carcinomatosis (PLC) occurs in about 6-8% of patients with lung metastasis and may rarely develop in the course of gastric cancer representing a complication due to diffuse metastasis in the lymphatics of the lungs. A 29-year-old female, admitted with difficulty in breathing and productive cough for one week, was initially evaluated for respiratory tract infection. During evaluation of associated anaemia an upper gastrointestinal endoscopy showed large ulcerative growth in the lesser curvature of the stomach suggestive of carcinoma...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966684/hyperbranched-polymer-drug-delivery-treatment-for-lung-metastasis-of-salivary-adenoid-cystic-carcinoma-in-nude-mice
#17
Weiwei Wang, Jialei Ma, Furong Jin, Jianxing Liao
Salivary adenoid cystic carcinoma (SACC) is associated with a high rate of lung metastasis. When lung metastasis occurs, the effects of traditional chemotherapy on SACC are poor. Hyperbranched polymer drug delivery (degradable hyperbranched polyglycerols, dHPGs) can be used as a strategy to load several drugs, and obtain beneficial effects on SACC lung metastasis through enhanced permeability and retention. In the present study, hydroxycamptothecin (HPT)-conjugated dHPG (dHPG-HPT) was synthesized and its effects on SACC xenografts in the lungs of nude mice were evaluated...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28966355/retrospective-evaluation-of-toceranib-palladia-treatment-for-canine-metastatic-appendicular-osteosarcoma
#18
Changseok Kim, Arata Matsuyama, Anthony J Mutsaers, J Paul Woods
This retrospective study evaluated the outcomes of dogs with macroscopic pulmonary metastasis of appendicular osteosarcoma (OSA) treated with toceranib. Medical records of 20 dogs with macroscopic pulmonary metastasis of OSA that received toceranib were reviewed. The median dose and duration of toceranib administration were 2.52 mg/kg (range: 2.12 to 2.72 mg/kg) and 60 days (range: 17 to 231 days). The median progression free survival (PFS) and overall survival (OS) were 36 days (range: 17 to 231 days) and 90 days (range: 17 to 433 days), respectively...
October 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28966242/the-role-of-e-cadherin-%C3%AE-catenin-in-hydroxysafflor-yellow-a-inhibiting-adhesion-invasion-migration-and-lung-metastasis-of-hepatoma-cells
#19
Long Ma, Li Liu, Yicong Ma, Hua Xie, Xue Yu, Xu Wang, Angran Fan, Dongyu Ge, Yingying Xu, Qian Zhang, Cai Song
Liver cancer is the second leading cause of cancer death. Due to treatments failures from drug resistance and cancer metastasis, discovering more effective treatments is imperative. As an angiogenesis inhibitor extracted from the Chinese herb-Safflower, hydroxysafflor yellow A (HSYA) inhibits the tumor growth in H22-bearing mice. Poorly differentiated hepatoma cells showed the ability to invade and metastasize, which are dependent on the angiogenesis. Accordingly, we hypothesized that HSYA could inhibit the metastasis of liver cancer cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28966230/difference-in-postsurgical-prognostic-factors-between-lung-adenocarcinoma-and-squamous-cell-carcinoma
#20
Haruhiko Nakamura, Hiroki Sakai, Hiroyuki Kimura, Tomoyuki Miyazawa, Hideki Marushima, Hisashi Saji
PURPOSE: The aim of this study was to compare the clinicopathologic prognostic factors between patients who underwent lung resection for adenocarcinoma (AD) and those with squamous cell carcinoma (SQ). METHODS: A database of patients with lung AD or SQ who underwent surgery with curative intent in our department from January 2008 to December 2014 was reviewed. Associations between various clinicopathologic factors, postsurgical recurrence-free survival (RFS), and overall survival (OS) were analyzed to find significant prognostic factors...
October 2, 2017: Annals of Thoracic and Cardiovascular Surgery
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