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Pulmonary metastasis

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https://www.readbyqxmd.com/read/29455167/pulmonary-metastasis-in-rectal-cancer-a-retrospective-study-of-clinicopathological-characteristics-of-404-patients-in-chinese-cohort
#1
Hong-Da Pan, Gang Zhao, Qi An, Gang Xiao
OBJECTIVES: This study aim to investigate the incidence, timing and risk factors of metachronous pulmonary recurrence after curative resection in patients with rectal cancer. DESIGN: A retrospective cohort study. SETTING: This study was conducted at a tertiary referral cancer hospital. PARTICIPANTS: A total of 404 patients with rectal cancer who underwent curative resection from 2007 to 2012 at Beijing Hospital were enrolled in this study...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29451347/a-rare-case-of-ectopic-papillary-thyroid-carcinoma-transformed-into-squamous-cell-carcinoma
#2
Hironao Yasuoka, Yasushi Nakamura, Ken-Ichi Yoshida, Toshiro Shimo, Masayuki Tori, Yuuki Matsui, Yasushi Sakamaki, Masahiko Tsujimoto
A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. During the post-operative follow-up period, a rapidly growing 2 cm nodular lesion in the lower left lobe of the lung was detected...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29449935/pleomorphic-liposarcoma-of-bone-a-rare-primary-malignant-bone-tumour
#3
G L Tiemeier, J M Brown, S E Pratap, C McCarthy, A Kastrenopoulou, K Bradley, S Wilson, Z Orosz, C L M H Gibbons, U Oppermann, N A Athanasou
Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29445139/dynamic-network-biomarker-indicates-pulmonary-metastasis-at-the-tipping-point-of-hepatocellular-carcinoma
#4
Biwei Yang, Meiyi Li, Wenqing Tang, Weixin Liu, Si Zhang, Luonan Chen, Jinglin Xia
Developing predictive biomarkers that can detect the tipping point before metastasis of hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To discover such early-warning signals or biomarkers of pulmonary metastasis in HCC, we analyse time-series gene expression data in spontaneous pulmonary metastasis mice HCCLM3-RFP model with our dynamic network biomarker (DNB) method, and identify CALML3 as a core DNB member. All experimental results of gain-of-function and loss-of-function studies show that CALML3 could indicate metastasis initiation and act as a suppressor of metastasis...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29437071/does-a-less-intensive-surveillance-protocol-affect-the-survival-of-patients-after-treatment-of-a-sarcoma-of-the-limb-updated-results-of-the-randomized-toss-study
#5
A Puri, P Ranganathan, A Gulia, S Crasto, R Hawaldar, R A Badwe
AIMS: A single-centre prospective randomized trial was conducted to investigate whether a less intensive follow-up protocol would not be inferior to a conventional follow-up protocol, in terms of overall survival, in patients who have undergone surgery for sarcoma of the limb. Initial short-term results were published in 2014. PATIENTS AND METHODS: The primary objective was to show non-inferiority of a chest radiograph (CXR) group compared with a CT scan group, and of a less frequent (six-monthly) group than a more frequent (three-monthly) group, in two-by-two comparison...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29435629/long-term-survival-and-prognostic-factors-of-pulmonary-metastasectomy-in-liver-cancer-a-systematic-review-and-meta-analysis
#6
Chong Wang, Lei Yang, Zikun Liang, Yaodong Liu, Shuku Liu
BACKGROUND: Lung is the most common extrahepatic metastatic organ of liver cancer. Surgical resection is a common local treatment for pulmonary metastasis. But the long-term prognosis of pulmonary metastasectomy varies greatly due to the small sample size and different results of previous studies. Therefore, we conducted this meta-analysis to evaluate the combined 5-year overall survival (OS) rate and prognostic factors after pulmonary metastasectomy in liver cancer. METHODS: Key words such as liver cancer pulmonary metastasis and metastasectomy were retrieved firstly in PubMed, Cochrane Library, Embase and Chinese Wanfang databases...
February 12, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29434921/correlation-between-circulating-tumor-cells-and-d-d-and-platelet-in-patients-with-pulmonary-malignancies
#7
Lijun Yang, Hai Dong, Zixuan Li, Yongyue Pan, La Qu, Zhiwen Tan
The aim of the present study was to investigate the correlation between circulating tumor cells (CTC) and D-dimer (D-D) and platelet (PLT) in patients with pulmonary malignancies. A total of 98 patients with lung cancer admitted to West China Hospital, Sichuan University, from June 2016 to February 2017 were enrolled in the present study. D-D and PLT levels were measured in the fasting elbow vein of the patients. The expression of CTC in peripheral blood was detected by negative separation using immunomagnetic beads and immunocytochemical staining...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29429162/-pulmonary-microcystic-fibromyxoma-report-of-a-case-with-review-of-literature
#8
Q X Gong, H Li, Z H Zhang, Q H Fan
Objective: To study the clinicopathologic features, diagnosis and differential diagnosis of pulmonary microcystic fibromyxoma. Methods: In March 2014, at the First Affiliated Hospital to Nanjing Medical University a 58-year-old female patient of pulmonary microcystic fibromyxoma was collected. The clinicopathologic, immunohistochemical and genetic profile of a case of pulmonary microcystic fibromyxoma were studied, and the relevant literature reviewed. Results: The patient was a 58-year-old female who presented with cough and sputum for 1 month...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29427436/highly-metastatic-k7m2-cell-line-a-novel-murine-model-capable-of-in-vivo-imaging-via-luciferase-vector-transfection
#9
Brian T Grisez, Justin J Ray, Phillip A Bostian, Justin E Markel, Brock A Lindsey
Osteosarcoma is rare and little improvement in survival rates has occurred in the last 25 years despite modern chemotherapeutic treatment. Bioluminescent cell lines for the modeling of osteosarcoma have shown success in tracking metastases in vivo, but commonly use adenoviral vectors to transfect the native cell line with bioluminescent reporters. The purpose of this study was to develop an orthotopic model for metastatic osteosarcoma capable of in vivo monitoring of metastatic and primary tumor burden in an immunocompetent mouse and compare that model to its wild type pathogenesis...
February 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29426046/-severe-thoracic-bleeding-25-years-after-nephrectomy
#10
H Rupprecht, H Dormann, A Marx, K Gaab
We report a case of a 62 year old patient, who was hospitalised due to haemorrhagic shock. The cause was a rupture of the pulmonary artery due to metastasis of a renal cell carcinoma. This cause is now reported for the first time. The primary tumour (pT2,pN0,M0,R0) was resected 25 years ago. This case demonstrates that after curative nephrectomy pulmonary metastasis can occur, even after decades. This is why patients of this type need lifelong follow-up.
February 9, 2018: Aktuelle Urologie
https://www.readbyqxmd.com/read/29423146/a-record-breaking-lung-metastasis-from-renal-cell-carcinoma-37-years-after-nephrectomy
#11
Alessandro Tamburrini, Aurelio Majorino, Simon Duggan, Sanjay Jogai, Aiman Alzetani
Development of distant metastases from renal cell carcinoma (RCC) is a frequent occurrence and, in nearly 95% of the cases, secondary lesions present within 5 years following nephrectomy. We performed a left pneumonectomy for a peri-hilar lung mass in an 81-year-old man with history of kidney cancer, resected 37 years earlier. Histopathological examination revealed a solitary lung metastasis from RCC, relapsed after an extraordinary 37-year time interval. To the best of our knowledge, this remarkable case represents the longest time interval between radical nephrectomy for RCC and the occurrence of a pulmonary metastasis...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29423083/betulinic-acid-impairs-metastasis-and-reduces-immunosuppressive-cells-in-breast-cancer-models
#12
An-Qi Zeng, Yan Yu, Yu-Qin Yao, Fang-Fang Yang, Mengya Liao, Lin-Jiang Song, Ya-Li Li, Yang Yu, Yu-Jue Li, Yuan-Le Deng, Shu-Ping Yang, Chen-Juan Zeng, Ping Liu, Yong-Mei Xie, Jin-Liang Yang, Yi-Wen Zhang, Ting-Hong Ye, Yu-Quan Wei
Breast cancer is the most common female cancer with considerable metastatic potential, explaining the need for new candidates that inhibit tumor metastasis. In our study, betulinic acid (BA), a kind of pentacyclic triterpenoid compound derived from birch trees, was evaluated for its anti-metastasis activity in vitro and in vivo. BA decreased the viability of three breast cancer cell lines and markedly impaired cell migration and invasion. In addition, BA could inhibit the activation of stat3 and FAK which resulted in a reduction of matrix metalloproteinases (MMPs), and increase of the MMPs inhibitor (TIMP-2) expression...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422972/detection-of-circulating-tumor-cells-in-pulmonary-venous-blood-for-resectable-non-small-cell-lung-cancer
#13
Chao Lv, Bingtian Zhao, Limin Wang, Panpan Zhang, Yuanyuan Ma, Yuzhao Wang, Nan Wu, Ying Wu, Yue Yang
Intraoperative manipulation causes circulating tumor cell (CTC) shedding into the blood and accelerates metastasis in non-small cell lung cancer (NSCLC). The present study was conducted to assess the degree of dissemination resulting from surgery and to explore the biological features of CTCs. In patients with NSCLC who underwent complete resection, the pulmonary vein (PV) was isolated and stapled following thoracotomy. The number of CTCs retained per 7.5 ml PV blood (CTC-PV) and peripheral blood were detected...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29417404/solitary-pulmonary-lesion-in-patients-with-history-of-malignancy-primary-lung-cancer-or-metastatic-cancer
#14
Ke Jin, Kexi Wang, Huizhong Zhang, Yuejiang Pan, Dexiong Cao, Minghui Wang, Ju Chen, Duoguang Wu, Boshen Chen, Xuan Xie
BACKGROUND: Defining the status of solitary pulmonary lesion (SPL) in patients with history of malignancy is important because primary lung cancer (PLC) or intrapulmonary metastasis might indicate different surgical strategies. The aim of this study is to identify factors related to the status of these lesions and construct a clinical model to estimate the pretest probability of PLC. METHODS: From January 2005 to January 2016, 104 patients with previous malignancy and suitable for surgery were retrospectively studied...
February 7, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29416782/nomogram-predicting-pulmonary-metastasis-of-hepatocellular-carcinoma-after-liver-transplantation
#15
Li-Feng Huang, Ping Wan, Dong-Wei Xu, Seogsong Jeong, Ming-Xuan Feng, Jian-Jun Zhang, Qiang Xia
A novel prognostic nomogram predicting post-transplant pulmonary metastasis was established with a primary cohort of 308 HCC patients who received liver transplantation between 2007 and 2011 at Ren Ji Hospital. The C-indexes for predicting pulmonary metastasis was 0.85. The calibration curves fitted well between the predicted and actual outcomes. The decision curve analysis indicated that our nomogram was the optimal decision-making strategy for PM prediction compared to Milan, University of California San Franscisco, and up-to-seven criteria...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416167/the-values-of-receptor-activator-nuclear-kappa-b-ligand-expression-in-stage-iii-giant-cell-tumor-of-the-bone
#16
Sabrina Abdul Ghani, Wan Faisham Wan Ismail, Md Salzihan Md Salleh, Sahran Yahaya, Zawawi Muhamad Syahrul Fitri
Background: Giant cell tumor (GCT) of bone is a benign locally aggressive primary bone tumor which is risky for local recurrences and pulmonary metastasis. Till date, there are still many uncertainties in predicting the aggressiveness of GCT. We aim to investigate whether receptor activator nuclear kappa-B ligand (RANKL) expression may determine the prognosis of the lesion. Materials and Methods: We examined RANKL expression in 39 patients (21 males, 18 females) by immunohistochemistry...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29416165/distal-medullary-canal-decompression-in-long-stem-hip-replacement-in-long-bone-metastasis-does-it-reduce-cardiopulmonary-complications
#17
Vivek Ajit Singh, Siamak Sarrafan, Ramesh Singh Veriah
Background: The femur is the most common long bone affected by metastatic bone disease, with 25% involving the proximal third of the femur. Long stem cemented hip replacement (LHR) is an important option for cases of impending fracture. Pulmonary embolism is a critical complication that can occur. This study evaluates the effectiveness of distal femoral canal decompression in reducing the risk of cardiopulmonary events. Materials and Methods: Thirty two patients with metastatic bone disease of the proximal femur undergoing LHR were recruited and randomized...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29411159/combined-pulmonary-fibrosis-and-emphysema-predicts-recurrence-following-surgery-in-patients-with-stage-i-non-small-cell-lung-cancer
#18
Ryo Maeda, Aika Funasaki, Nozomu Motono, Atsushi Sekimura, Katsuo Usuda, Hidetaka Uramoto
The purpose of this study was to clarify the clinicopathologic characteristics of non-small cell lung cancer (NSCLC) patients with combined pulmonary fibrosis and emphysema (CPFE). We investigated the association between CPFE, the cancer survival, and the pathological features of clinical stage I NSCLC patients. Between 2005 and 2014, 218 consecutive patients with clinical stage I NSCLC underwent complete resection with systematic lymph node dissection. A univariate analysis by log-rank tests was performed to determine the risk factors for recurrence, and the Cox proportional hazards regression model was used to identify potential independent predictors...
February 6, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29409771/development-of-low-molecular-weight-heparin-based-nanoparticles-for-metastatic-breast-cancer-therapy
#19
Haifeng Sun, Dinglingge Cao, Hao Wu, Huan Liu, Xue Ke, Tianyuan Ci
Tumor metastasis is the primary obstacle in cancer treatment and is always the leading cause of human death. And heparin and its derivatives are potential anti-metastatic agents with good biocompatibility. In this work, low molecular weight heparin (LMWH) based LMWH-Cholesterol (LHC) conjugates were prepared for intravenous delivery of doxorubicin (DOX). The DOX/LHC nanoparticles (DOX/LHC NPs) exhibited a spherical shape with a mean diameter of 135.5 ± 2.2 nm and had a longer circulation time than that of DOX...
January 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29409495/pd-1-axis-expression-in-musculoskeletal-tumors-and-antitumor-effect-of-nivolumab-in-osteosarcoma-model-of-humanized-mouse
#20
Bingxin Zheng, Tingting Ren, Yi Huang, Kunkun Sun, Shidong Wang, Xing Bao, Kuisheng Liu, Wei Guo
BACKGROUND: Immune checkpoint inhibitors have led to a breakthrough in solid tumor immunotherapy, but related studies on musculoskeletal tumors are few, especially for PD-L2. METHODS: We examined expression of three molecular effectors of the PD-1 axis in 234 patients with musculoskeletal tumors, including osteosarcoma, chondrosarcoma, synovial sarcoma, and giant cell tumor. Survival analyses and potential mechanisms were investigated in osteosarcoma per the Gene Expression Omnibus (GEO) and immunohistochemistry analyses...
February 6, 2018: Journal of Hematology & Oncology
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