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Pulmonary metastasis

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https://www.readbyqxmd.com/read/29904902/acute-appendicitis-caused-by-metastatic-adenocarcinoma-from-the-lung-a-case-report
#1
Yusuke Kimura, Takafumi Machimoto, Daiki Yasukawa, Yuki Aisu, Tomohide Hori
BACKGROUND: Appendiceal metastasis from lung cancer is rare. However, it often causes acute appendicitis that requires emergency surgery. We herein report a thought-provoking case of appendiceal metastasis from lung cancer. CASE PRESENTATION: A 71-year-old man was diagnosed with advanced lung cancer with multiple metastases and underwent chemotherapy. One month later, he developed acute appendicitis, and laparoscopic appendectomy was promptly performed. A swollen appendix and pus collection were observed during surgery...
June 15, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29904593/case-report-pulmonary-and-liver-sarcoidosis-suspected-of-metastasis
#2
Behnam Jafari, Gholamabas Sabz, Elahe Masnavi, Roghaye Panahi, Saeid Jokar, Amrollah Roozbehi, Sajad Hasanzadeh
Introduction : Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Case report : A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment...
2018: F1000Research
https://www.readbyqxmd.com/read/29902845/-clinical-practice-of-repair-of-large-tracheal-defects-with-local-tension-free-flaps
#3
Y H Wu, S Y Liu
Objective: To investigate a simple and practical method for the repair of large tracheal defects. Methods: From April 2015 to October 2017, 10 patients with large tracheal wall defects after thyroid carcinoma underwent two phase repair with cervical tension free flap with modified design. In the longitudinal direction of the leakage, design two pieces of random flap outside the top angle of 45°, respectively, and the side turn double flip flap to repair the leak, outward and upward forming tension, avoid collapse after healing...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29901634/high-dose-fulvestrant-as-third-line-endocrine-therapy-for-breast-cancer-metastasis-to-the-left-kidney-a-case-report-and-literature-review
#4
Dandan Xia, Huiyu Wang, Runjie Wang, Chaoying Liu, Junying Xu
RATIONALE: Endocrine therapy plays an important role in the treatment of patients with hormone receptor-positive breast cancer. Renal metastasis of breast cancer is rare in clinical practice. PATIENT CONCERNS: We present here a 54-year-old woman with breast cancer after first line chemotherapy and second line endocrinotherapy (i.e., toremifene & exemestane) failure. DIAGNOSES: The patient was rarely diagnosed breast cancer metastasis to the kidney and a positive hormone status (ER and PR) but was negative for human epidermal factor receptor 2 (HER2)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901596/multiple-gastrointestinal-metastases-of-squamous-cell-lung-cancer-a-case-report
#5
Xinyu Li, Songhe Li, Zhiming Ma, Shutao Zhao, Xudong Wang, Dacheng Wen
RATIONALE: Gastrointestinal multiple metastases of lung cancer are extremely rare. The majority of gastrointestinal metastasis cases are diagnosed at a late stage and the prognosis is extremely poor. This report describes the clinical characteristics and outcomes of a patient with gastrointestinal multiple metastases from squamous-cell lung cancer, with special emphasis on the diagnosis and treatment of metastatic lung cancer. PATIENT CONCERNS: A 61-year-old man who presented with progressive abdominal distention was admitted to our hospital...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899399/hedgehog-signalling-in-the-tumourigenesis-and-metastasis-of-osteosarcoma-and-its-potential-value-in-the-clinical-therapy-of-osteosarcoma
#6
Zhihong Yao, Lei Han, Yongbin Chen, Fei He, Bin Sun, Santosh Kamar, Ya Zhang, Yihao Yang, Cao Wang, Zuozhang Yang
The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary osteosarcoma metastases are especially difficult to control. In the present paper, we summarise recent studies on the regulation of osteosarcoma progression and metastasis by downregulating Hh signalling. We also summarise the crosstalk between the Hh pathway and other cancer-related pathways in the tumourigenesis of various cancers...
June 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29891107/surgical-treatment-of-pulmonary-metastasis-in-colorectal-cancer-patients-current-practice-and-results
#7
REVIEW
Matthieu Zellweger, Etienne Abdelnour-Berchtold, Thorsten Krueger, Hans-Beat Ris, Jean Yannis Perentes, Michel Gonzalez
Colorectal cancer (CRC) is a frequently occurring disease, yet diagnosed at a local stage in only 40% of cases. Lung metastases (LM) appear in 5-15% of patients and, left untreated, carry a very poor prognosis. Some CRC patients may benefit from a potentially curative LM resection, but success and benefit are difficult to predict. We discuss prognostic factors of survival after lung metastasectomy in CRC patients under several scenarios (with/ without prior liver metastases; repetitive pulmonary resections)...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29888431/differential-proteomic-analysis-between-small-cell-lung-carcinoma-sclc-and-pulmonary-carcinoid-tumors-reveals-molecular-signatures-for-malignancy-in-lung-cancer
#8
Kiyonaga Fujii, Yuka Miyata, Ikuya Takahashi, Hirotaka Koizumi, Hisashi Saji, Masahiro Hoshikawa, Masayuki Takagi, Toshihide Nishimura, Haruhiko Nakamura
PURPOSE: The molecular underpinnings that may prognosticate survival and increase our understanding of tumor development and progression are still poorly understood. This study aimed to define the molecular signatures for malignancy in small cell lung carcinoma (SCLC), which is known for its highly aggressive clinical features and poor prognosis. EXPERIMENTAL DESIGN: Using clinical specimens, we performed a comparative proteomic analysis of high-grade SCLCs and low-grade pulmonary carcinoid tumors (PCTs), both of which are types of neuroendocrine tumors...
June 11, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29885833/combination-therapy-with-bh3-mimetic-and-hyperthermia-tends-to-be-more-effective-on-anti-melanoma-treatment
#9
Zhen Shi, Bin Lan, Baowei Peng, Xuefeng Wang, Ganggang Zhang, Xiaohu Li, Fang Guo
Malignant melanoma has shown increased incidence and high mortality rate in the last three decades. In this study, we investigated whether combination therapy with ch282-5 (a novel BH3 mimetic) and microwave hyperthermia could display synergistic antitumor effects against melanoma. Our results indicated that combination therapy reduced the viability and proliferation of melanoma cells. Through inhibiting the expression of anti-apoptotic proteins of Bcl-2 and IAP family and activating MAPK proteins, combined hyperthermia enhanced ch282-5-induced apoptosis...
June 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29883826/diagnosis-therapy-and-therapeutic-effects-in-cases-of-pituitary-metastasis
#10
REVIEW
Yi Zhao, Wei Lian, Bing Xing, Ming Feng, Xiaohai Liu, Renzhi Wang, Weixun Zhou
OBJECTIVE: This study aimed to summarize the diagnosis, therapy and prognosis of pituitary metastasis. METHODS: Ten patients from the Department of Neurosurgery of the Peking Union Medical College Hospital (PUMCH) from Apr. 1997 to Aug. 2014 were retrospectively analyzed. RESULTS: The participants included 7 males (70%) and 3 females (30%), with an average age of 60.4 years. The most common initial clinical feature was visual disability (50%)...
June 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29882471/microrna-222-promotes-invasion-and-metastasis-of-papillary-thyroid-cancer-through-targeting-protein-phosphatase-2-regulatory-subunit-b-alpha-expression
#11
Yanrui Huang, Shuang Yu, Siting Cao, Yali Yin, Shubin Hong, Hongyu Guan, Yanbing Li, Haipeng Xiao
BACKGROUND: Increasing evidence indicates that microRNA dysfunction is involved in the pathogenesis and progression of cancer. MicroRNA-222 (miR-222) is upregulated in papillary thyroid carcinoma (PTC); however, the role of miR-222 in invasion and metastasis of PTC remains unknown. In this study, we investigated the function of miR-222 and its underlying mechanism in the progression of PTC. METHODS: The expression of miR-222 was detected by qRT-PCR and its correlation with various clinical characteristics was analyzed...
June 8, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29880037/decreased-expression-of-sry-box-containing-gene-30-is-related-to-malignant-phenotypes-of-human-bladder-cancer-and-correlates-with-poor-prognosis
#12
Yang Liu, Han Wang, Jianhua Zhong, Chenglong Wu, Gang Yang, Yuantang Zhong, Jinghua Zhang, Aifa Tang
BACKGROUND: In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene. Nevertheless, its molecular role and clinical effects remains unknown in bladder cancer. METHODS: SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR. SOX30 protein expression in BC tissue and cell lines was evaluated via western blotting and immunohistochemistry. In addition, the clinical and prognostic significance of SOX30 in BC were assessed using Kaplan-Meier analysis...
June 7, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29879078/treatment-rationale-and-design-of-the-spiral-study-a-phase-ii-trial-of-osimertinib-in-elderly-epidermal-growth-factor-receptor-t790m-positive-nonsmall-cell-lung-cancer-patients-who-progressed-during-prior-egfr-tki-treatment
#13
Junji Uchino, Akira Nakao, Nobuyo Tamiya, Yoshiko Kaneko, Tadaaki Yamada, Kenichi Yoshimura, Masaki Fujita, Koichi Takayama
BACKGROUND: Advances in epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment led to research on the mechanism of the resistance have revealed that an occurrence of T790M gene mutation generated in exon 20 of the EGFR gene is associated with approximately 50% to 60% of observed resistance. Osimertinib, a 3rd-generation EGFR-TKI, has been shown to be effective against both EGFR tyrosine kinase inhibitor-sensitizing and T790M resistance mutations. In this study, we prospectively investigate the efficacy and safety of osimertinib in elderly patients aged ≥75 years, with ineffective prior EGFR-TKI treatment or with recurrence of EGFR-TKI mutation-positive or T790M mutation-positive nonsmall-cell lung cancer...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29879077/metastasizing-pleomorphic-adenoma-in-the-multiple-organs-a-case-report-on-fdg-pet-ct-imaging
#14
Masamichi Koyama, Takashi Terauchi, Mitsuru Koizumi, Hiroko Tanaka, Yukiko Sato
RATIONALE: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. We herein report an unusual case of pleomorphic adenoma with multiple metastases comprehensively demonstrated on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29878373/reconstruction-with-constrained-scapular-prosthesis-after-total-scapulectomy-for-scapular-malignant-tumor
#15
Baichuan Wang, Qiang Wu, Zhicai Zhang, Jianxiang Liu, Zengwu Shao
BACKGROUND: Surgical reconstruction after total scapulectomy presents a great challenge. Currently, the constrained scapular prosthesis reconstruction is considered as the most effective and promising method. However, the mid- to long-term functional outcomes and complications of this procedure are unclear. METHODS: We retrospectively analyzed eight patients with scapular malignant tumors treated by total scapulectomy and constrained scapular prosthesis reconstruction between 2011 and 2013...
June 7, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29874900/malignant-pleural-effusion-from-metastatic-prostate-cancer-a-case-report-with-unusual-cytologic-findings
#16
Jinyoung Jeon, Tae-Jung Kim, Hong Sik Park, Kyo-Young Lee
We present a case of 55-year-old man who complained of dyspnea and sputum for a month. He was an ex-smoker having a history of prostate cancer and pulmonary tuberculosis. Chest radiographs revealed small to moderate amount of bilateral pleural effusions. Pigtail catheters were inserted and drainage was performed. The pleural fluid contained malignant cells, arranged in large clusters and tightly cohesive groups. These cytologic findings could not with certainty be ascribed to prostate cancer. We performed immunocytochemical (ICH) panel studies to determine the origin of cancer metastasis...
June 7, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29869202/pulmonary-administration-of-curcumin-inhibits-b16f10-melanoma-lung-metastasis-and-invasion-in-mice
#17
Ken Shimada, Kentaro Ushijima, Chisato Suzuki, Michiko Horiguchi, Hitoshi Ando, Tomomi Akita, Mizuki Shimamura, Junki Fujii, Chikamasa Yamashita, Akio Fujimura
PURPOSE: Curcumin is expected to have beneficial effects including an anti-cancer effect. However, its lower bioavailability is a critical concern and limits the utility of curcumin in clinical practice. In this study, we investigated whether transpulmonary delivery of curcumin is pharmacologically effective along with improving its bioavailability in mice with lung metastasis. METHODS: C57BL/6J mice were injected with B16F10 melanoma cells via their tail vein and given curcumin by pulmonary administration every other day...
June 4, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29866243/marked-response-to-icotinib-in-lung-squamous-cell-carcinoma-with-egfr-wild-type
#18
Tao Fan, Ju-Ying Zhou
We present a case of a 72-year male with primary lung squamous cell carcinoma without an epidermal growth factor receptor (EGFR) gene mutation that exhibited a lasting efficacy to icotinib treatment. Originally, the patient was treated with GP regimen for 2 cycles, local lesion radiotherapy (DT46Gy/2Gy*23F), and TP regimen for 2 cycles, with efficacy evaluation as stable disease (SD). The condition was stable for 10 months until the fifth lumbar metastasis was discovered by emission computed tomography (ECT) in July 2015, and the pulmonary metastasis increased...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29866242/secondary-ameloblastic-carcinoma-of-mandible-with-pulmonary-metastasis
#19
Syeda Sara Tajammul, Usman Ali, Faiza Kazi, Hassan Mahmood
Ameloblastic carcinoma (AC) is a very rare odontogenic malignancy. Primary AC is more common in maxilla, while secondary AC is more common in mandible. Histologically, it is an ameloblastoma with features of cancer. Presence of metastasis is not necessary to establish the diagnosis. This tumor usually metastasises in bone or lungs. We report a case of aggressive secondary AC of mandible with lung metastasis. There are few cases in medical literature discussing management of AC with lung metastasis. In this case, a 42-year woman, who was diagnosed with ameloblastoma of right mandible, was treated with right hemi-mandibulectomy...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29859750/novel-leucine-ureido-derivatives-as-aminopeptidase-n-inhibitors-using-click-chemistry
#20
Jiangying Cao, Chunhua Ma, Jie Zang, Shuai Gao, Qianwen Gao, Xiujie Kong, Yugang Yan, Xuewu Liang, Qin'ge Ding, Chunlong Zhao, Binghe Wang, Wenfang Xu, Yingjie Zhang
The over-expression of aminopeptidase N on diverse malignant cells is associated with the tumor angiogenesis and metastasis. In this report, one new series of leucine ureido derivatives containing the triazole moiety was designed, synthesized and evaluated as APN inhibitors. Among them, compound 13v showed the best APN inhibition with an IC50 value of 0.089 ± 0.007 μM, which was two orders of magnitude lower than that of bestatin (IC50  = 9.4 ± 0.5 μM). Compound 13v also showed dose-dependent anti-angiogenesis activities...
April 22, 2018: Bioorganic & Medicinal Chemistry
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