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Nocturnal asthma

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https://www.readbyqxmd.com/read/29992713/continuous-positive-airway-pressure-for-obstructive-sleep-apnoea-does-not-improve-asthma-control
#1
Susanna S S Ng, Tat-On Chan, Kin-Wang To, Ken K P Chan, Jenny Ngai, Wing-Ho Yip, Rachel L P Lo, Fanny W S Ko, David S C Hui
BACKGROUND AND OBJECTIVE: Unrecognized obstructive sleep apnoea syndrome (OSAS) may lead to poor asthma control despite optimal therapy. We assessed asthma control, airway responsiveness, daytime sleepiness and health status at baseline and 3 months after continuous positive airway pressure (CPAP) treatment among asthma patients with nocturnal symptoms and OSAS. METHODS: Patients with nocturnal asthma symptoms despite receiving at least moderate-dose inhaled corticosteroid and long-acting bronchodilators underwent a home sleep study using 'Embletta' portable diagnostic system...
July 10, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29990113/nocturnal-heart-rate-variability-spectrum-characterization-in-preschool-children-with-asthmatic-symptoms
#2
Javier Milagro, Eduardo Gil, Jesus Lazaro, Ville-Pekka Seppae, Leo Pekka Malmberg, Anna Susanna Pelkonen, Anne Kotaniemi-Syrjanen, Mika Makela, Jari Viik, Raquel Bailon
Asthma is a chronic lung disease that usually develops during chilhood. Despite that symptoms can almost be controlled with medication, early diagnosis is desirable in order to reduce permanent airway obstruction risk. It has been suggested that abnormal parasympathetic nervous system (PSNS) activity might be closely related with the pathogenesis of asthma, and that this PSNS activity could be reflected in cardiac vagal control. In this work, an index to measure the spectral regularity of the high frequency (HF) component of heart rate variability (HRV) spectrum, named peakness (P), is proposed...
November 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/29958011/efficacy-and-safety-of-the-combination-fluticasone-propionate-plus-salmeterol-in-asthmatic-preschoolers-an-observational-study
#3
Elpis Hatziagorou, Eleana Kouroukli, Maria Galogavrou, Dafni Papanikolaou, Dr Despoina Terzi, Pinelopi Anagnostopoulou, Fotios Kirvassilis, Demosthenes B Panagiotakos, John Tsanakas
BACKGROUND: Inhaled Corticosteroids (ICS) are the cornerstone of asthma management in pediatric patients. However, in some cases, asthma is not adequately controlled on ICS alone. Long-acting beta2 -agonists (LABA) are one of the available additional therapies but their use has rarely been studied among children younger than 5 years. OBJECTIVE: The aim of this observational study was to evaluate the efficacy and safety of the combination of fluticasone propionate and salmeterol (FP/SA) in asthmatic children younger than 5 years of age...
June 29, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29786596/-coexistence-of-asthma-and-obstructive-sleep-apnea-syndrome-review-of-the-literature
#4
Magdalena Pawelec-Winiarz, Anna Brzecka
Both asthma and obstructive sleep apnea (OSA) syndrome are frequent diseases and their coexistence may implicate important consequences. The incidence of OSA syndrome among the patients with asthma is higher than in the general population, especially in the patients with nocturnal symptoms persisting despite treatment, in patients frequently admitted to hospital because of the exacerbations of asthma, and in obese patients. The causes of frequent coexistence of asthma and OSA syndrome are not fully elucidated...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29771038/-efficacy-of-standardized-sublingual-immunotherapy-of-allergic-asthma-with-rhinitis-in-children-between-different-age-groups
#5
S J Wu, S Chen, B Chen, L Wang, X Zeng
Objective: The aim of this study is to evaluate the efficacy of standardized sublingual immunotherapy of allergic asthma with rhinitis in children between two different age groups. Method: Retrospective analysis of 250 patients with allergic asthma and rhinitis who received SLIT treatment. According to the age divided into younger children group (aged 3-6 years, 128 patients) and older children group (aged 7-13 years, 122 patients). Evaluate the asthma daytime, nocturnal symptom, medication score, VAS score and pulmonary function FEV1, PEF% level and rhinitis symptom and medication score before and after treatment of two groups of children...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29702689/wheezing-phenotypes-and-risk-factors-in-early-life-the-elfe-cohort
#6
Souheil Hallit, Benedicte Leynaert, Marie Christine Delmas, Steffi Rocchi, Jacques De Blic, Christophe Marguet, Emeline Scherer, Marie Noelle Dufourg, Corinne Bois, Gabriel Reboux, Laurence Millon, Marie Aline Charles, Chantal Raherison
OBJECTIVE: Different phenotypes of wheezing have been described to date but not in early life. We aim to describe wheezing phenotypes between the ages of two months and one year, and assess risk factors associated with these wheezing phenotypes in a large birth cohort. METHODS: We studied 18,041 infants from the ELFE (French Longitudinal Study of Children) birth cohort. Parents reported wheezing and respiratory symptoms at two and 12 months, and answered a complete questionnaire (exposure during pregnancy, parental allergy)...
2018: PloS One
https://www.readbyqxmd.com/read/29688023/passive-nocturnal-physiologic-monitoring-enables-early-detection-of-exacerbations-in-asthmatic-children-a-proof-of-concept-study
#7
Michelle F Huffaker, Michael Carchia, Bronwyn U Harris, William C Kethman, Todd E Murphy, Charlotte C D Sakarovitch, FeiFei Qin, David N Cornfield
RATIONALE: Asthma management depends on prompt identification of symptoms, which challenges both patients and providers. In asthma, a misapprehension of health between exacerbations can compromise compliance. Thus, there is a need for a tool that permits objective longitudinal monitoring without increasing the burden of patient compliance. OBJECTIVES: We sought to determine whether changes in nocturnal physiology are associated with asthma symptoms in pediatric patients...
April 24, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29682796/phase-2a-randomized-double-blind-placebo-controlled-multicentre-parallel-group-study-of-an-h-4-r-antagonist-jnj-39758979-in-adults-with-uncontrolled-asthma
#8
A P Kollmeier, A Greenspan, X L Xu, P E Silkoff, E S Barnathan, M J Loza, J Jiang, B Zhou, B Chen, R L Thurmond
BACKGROUND: The effects of H4 R antagonists in preclinical asthma models support the study of antagonists of the H4 R in the treatment of asthma in humans. JNJ-39758979 is a potent and highly selective oral H4 R antagonist. OBJECTIVE: We sought to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult patients with uncontrolled asthma. METHODS: One hundred and fifteen eligible patients were randomly assigned to JNJ-39758979 300 mg or placebo once daily for 12 weeks in this phase 2a, double-blind, multicenter, placebo-controlled study...
April 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29643544/-bronchial-adenoid-cystic-carcinoma-masquerading-as-bronchial-asthma-a-case-report
#9
M Lu, M Wang, X Zhu, Y H Chen, W Z Yao
Here we reported a case of bronchial adenoid cystic carcinoma from Peking University Third Hospital. A 40-year-old female presented with dry cough for 1 year and nocturnal paroxysmal attacks of wheezing for 4 months. She was a non-smoker, and did not have past histories of asthma or allergy. On physical examination, no stridor, wheezing and cyanosis were present and the general appearance was good. The results of the laboratory analysis, including blood eosinophils count, immunoglobulin E level and chest X-ray were normal...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29602485/-occurrence-of-delayed-symptoms-after-a-challenge-test-with-methacholine
#10
E Cabon, F Rey, D Tissier-Ducamp, M J Del Volgo, S Delliaux, M Bues-Charbit, D Charpin, F Brégeon
There are few prospective studies available on the development of delayed symptoms following challenge tests with methacholine (MCT) at the currently recommended doses. The objective of this study was to describe the nature and frequency of respiratory symptoms suggestive of bronchospasm developing within 24hours after a MCT. The study was offered to adult patients who underwent MCT seen consecutively between June and October 2015. Following the test, a questionnaire adapted from the GINA asthma control questionnaire bearing on diurnal and nocturnal symptoms (cough, dyspnoea, wheeze and tightness), was delivered to the patient and the replies collected by telephone 24hours later...
March 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29456039/exposure-to-dogs-but-not-cats-is-associated-to-a-decrease-in-the-prevalence-in-atopic-dermatitis-amongst-school-children
#11
M Bedolla-Barajas, J Morales-Romero, T I Bedolla-Pulido, T R Bedolla-Pulido, C Meza-López, N A Pulido-Guillén
INTRODUCTION: The association regarding the exposure to pets, especially cats and dogs, and the prevalence of allergic diseases is inconsistent. OBJECTIVE: We analyzed the role played by early exposure to dogs or cats in the prevalence of allergic diseases amongst school-aged children. METHOD: Through a cross-sectional study, we examined 756 children, aged 6-7; these candidates were selected through cluster sampling. We inquired about the exposure that these children had had to dogs and cats, and whether these pets spent most of their time indoors or outdoors during the first year of the child's life...
February 15, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29394961/effects-of-coexisting-asthma-and-obstructive-sleep-apnea-on-sleep-architecture-oxygen-saturation-and-systemic-inflammation-in-women
#12
Fredrik Sundbom, Christer Janson, Andrei Malinovschi, Eva Lindberg
STUDY OBJECTIVES: Both asthma and obstructive sleep apnea (OSA) are strongly associated with poor sleep. Asthma and OSA also have several features in common, including airway obstruction, systemic inflammation, and an association with obesity. The aim was to analyze the effect of asthma, OSA, and the combination of asthma and OSA on objectively measured sleep quality and systemic inflammation. METHODS: Sleep and health in women is an ongoing community-based study in Uppsala, Sweden...
February 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29237390/chronopharmacokinetic-evaluation-of-budesonide-multiparticulate-systems
#13
Sowjanya Battu, Prasanna R Yalavarthi, Venkata S R Gopireddy, Uma M R Vattikuti, Jyothshna Devi, Harini C Vadlamudi
BACKGROUND: Poor oral absorption of budesonide limits the design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study. METHODS: Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Uniform sized non-pareil seeds (~400 µm) were coated with solid dispersions to obtain immediate (BMP) and controlled release pellets by solution layering technique...
2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29227026/the-prevalence-of-asthma-in-iranian-adults-the-first-national-survey-and-the-most-recent-updates
#14
Mohammad Reza Fazlollahi, Mehdi Najmi, Mojtaba Fallahnezhad, Nastaran Sabetkish, Anoshirvan Kazemnejad, Katayoon Bidad, Raheleh Shokouhi Shoormasti, Maryam Mahloujirad, Zahra Pourpak, Mostafa Moin
BACKGROUND: The worldwide increase in the prevalence of asthma has made it a major public-health concern. We aimed to identify the prevalence of asthma and asthma symptoms in adults living in urban and rural areas of Iran as a populated country with about 80 millions of residents. METHODS: This cross-sectional study was conducted to estimate the prevalence of asthma in adults between 20 and 44 years old in all provinces of Iran. Data were collected by personal interview via a standardized questionnaire [European Community Respiratory Health Survey (ECRHS)] between November 2015 and February 2016...
May 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29196001/allium-tuberosum-antidiabetic-and-hepatoprotective-activities
#15
Xingli Tang, Opeyemi J Olatunji, Yifeng Zhou, Xilin Hou
Allium tuberosum (AT) is traditionally used for treating nocturnal emissions, abdominal pain, diarrhea, sexual dysfunction and asthma. This study aimed at investigating the antidiabetic and hepatoprotective activities of the butyl alcohol fraction from the methanolic extract of A. tuberosum. For the antidiabetic activity, rats were induced with diabetes by intraperitoneal injection of 150mg/kg alloxan and treated for 30days with AT extract (100, 200 and 400mg/kg). Animals were sacrificed after the study and the fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), HDL, malondialdehyde (MDA) catalase, superoxide dismutase and glutathione levels were determined...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29193245/review-article-gastro-oesophageal-reflux-disease-in-asthma-and-chronic-obstructive-pulmonary-disease
#16
REVIEW
C Broers, J Tack, A Pauwels
BACKGROUND: When gastro-oesophageal reflux is causing symptoms or lesions in the oesophagus, this is referred to as gastro-oesophageal reflux disease (GERD). GERD can manifest itself through typical symptoms (heartburn, regurgitation) or may lead to extra-oesophageal symptoms. Extra-oesophageal manifestations of GERD gained increasing attention over the last decade, especially respiratory disorders, because of the prevalent co-occurrence with GERD. The role of GERD in the pathogenesis of respiratory disorders has become a topic of intense discussion...
January 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29178682/real-life-clinical-use-of-symbicort%C3%A2-maintenance-and-reliever-therapy-for-asthmatic-patients-in-korea
#17
Sang Hoon Kim, Tae Bum Kim, Sang Heon Kim, Heung Woo Park, Sook Hee Song, Jae Won Jeong, Young Koo Jee, Sang Won Park, Mi Sun Kim, Ho Joo Yoon
The aim of this study was to examine the daily practice patterns of Symbicort® Maintenance and Reliever Therapy (SMART) in Korean asthmatic patients and to analyze clinical signs related to overuse. This study used an observational, multicenter, noninterventional, prospective, uncontrolled design for examining asthmatic patients prescribed SMART to assess the frequency and pattern of Symbicort® usage as a maintenance and reliever medication. The characteristics of patients showing signs of overuse (frequency of inhalation: 8 or more times per day) were also analyzed...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29153413/an-objective-evaluation-of-nocturnal-cough-count-and-cough-pattern-in-children-with-psychogenic-cough
#18
REVIEW
Eri Imai, Kota Hirai, Yoshiko Mikami, Mariko Nukaga, Mayumi Enseki, Hideyuki Tabata, Masahiko Kato, Hiroyuki Mochizuki
Two patients with a chronic, barking cough were diagnosed with psychogenic cough. Using an original cough counter we studied the nocturnal cough count and pattern. While the number of coughs when awake was extremely high for both patients, the number of coughs was remarkably reduced during sleep, similar to an exacerbation of asthma. Moreover, the properties of the coughs when awake were clearly different from those of coughs during sleep. In conclusion, an objective examination using a cough counter was useful for the diagnosis, treatment and management of psychogenic cough...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29066920/study-of-the-clinical-and-functional-characteristics-of-asthmatic-children-with-obstructive-sleep-apnea
#19
Yen Nguyen-Hoang, Thuy Nguyen-Thi-Dieu, Sy Duong-Quy
BACKGROUND AND OBJECTIVE: The obstructive sleep apnea (OSA) is a common respiratory disorder in children, especially those at preschool and school ages. This study aimed to describe the characteristics of asthmatic children with OSA and the symptoms for a high risk of OSA. SUBJECTS AND METHODS: It was a prospective and descriptive study. The data of asthmatic children including medical history, clinical examination, blood tests, spirometry, exhaled nitric oxide (NO), and respiratory polygraphy were registered for analyses...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29037301/asthma-symptoms-among-chinese-children-the-role-of-ventilation-and-pm-10-exposure-at-school-and-home
#20
X-J Fan, C Yang, L Zhang, Q Fan, T Li, X Bai, Z-H Zhao, X Zhang, D Norback
SETTING: Respiratory symptoms in relation to environment in Taiyuan, China. OBJECTIVE: To study associations between school/home exposure and prevalence of respiratory symptoms and self-reported respiratory infections (RIs) among students. DESIGN: A total of 2134 pupils from 10 schools answered a questionnaire; air pollution at school was measured. RESULTS: The prevalence of current wheeze, daytime attacks of breathlessness, nocturnal cough, nocturnal respiratory symptoms and RI was respectively 4...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
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