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Nocturnal asthma

Cristina de Oliveira Francisco, Swati Anil Bhatawadekar, Jessica Babineau, W Darlene Reid, Azadeh Yadollahi
INTRODUCTION: Nocturnal worsening of asthma symptoms is a common feature of asthma. Physical exercise training improves general asthma control; however, there is no evidence showing the effects of physical exercise on nocturnal asthma symptoms. Indeed, asthma patients with daytime and nighttime symptoms are physiologically different, and thus the effects of physical exercise on asthma may also be different in these two groups. The objective of this systematic review is to explore the effects of physical exercise on nocturnal asthma symptoms...
2018: PloS One
Sumaiah Jamal Alarfaj, Rabah Al-Mehisen, Imad Elhag, Nayef Mohammed Kazzaz
A 35-year-old black Saudi man, with a known case of bronchial asthma and allergic rhinitis since childhood, presented with joint pain and swelling, orthopnoea, paroxysmal nocturnal dyspnoea and lower extremity oedema. On examination, we found jugular venous distension, bilateral basal crepitation, wheezing and diffuse synovitis. Investigations were notable for peripheral blood eosinophilia, pericardial effusion and elongated structure in the left ventricular outflow tract on echocardiography, mediastinal and hilar lymphadenopathy and right upper lobe infiltrate on high-resolution CT scan...
October 17, 2018: BMJ Case Reports
Ikenna C Eze, Maria Foraster, Emmanuel Schaffner, Danielle Vienneau, Harris Héritier, Reto Pieren, Laurie Thiesse, Franziska Rudzik, Thomas Rothe, Marco Pons, Robert Bettschart, Christian Schindler, Christian Cajochen, Jean-Marc Wunderli, Mark Brink, Martin Röösli, Nicole Probst-Hensch
Transportation noise leads to sleep disturbance and to psychological and physiological sustained stress reactions, which could impact respiratory health. However, epidemiologic evidence on associations of objective transportation noise exposure and also perceived noise annoyance with respiratory morbidity is limited. We investigated independent associations of transportation noise exposure and noise annoyance with prevalent respiratory symptoms and incident asthma in adults. Using 17,138 observations (from 7049 participants) from three SAPALDIA (Swiss Cohort Study on Lung and Heart Diseases in Adults) surveys, we assessed associations of transportation noise exposure and noise annoyance with prevalent respiratory symptoms, and with incident asthma (in 10,657 nested observations from 6377 participants)...
December 2018: Environment International
Rimon Sobhi Azzam
BACKGROUND: Gastroesophageal reflux disease (GERD) is a clinical condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Transient lower esophageal sphincter relaxation is the main pathophysiological mechanism of GERD. Symptoms and complications can be related to the reflux of gastric contents into the esophagus, oral cavity, larynx and/or the lung. Symptoms and other possible manifestations of GERD are heartburn, regurgitation, dysphagia, non-cardiac chest pain, chronic cough, chronic laryngitis, asthma and dental erosions...
October 4, 2018: Arquivos de Gastroenterologia
Pei-Hsuan Lai, Pei-Shan Yang, Wan-Yu Lai, Cheng-Li Lin, Chung-Y Hsu, Chang-Ching Wei
BACKGROUND: Despite controversy, an association between allergy and nocturnal enuresis (NE) has been reported for almost a century. Allergic rhinitis (AR)-associated sleep-disordered breathing frequently results in microarousals during sleep, decreased sleep efficiency, and change in sleep pattern and behavior. NE is a common sleep disorder in children. Hence, this study aimed to investigate the incidence and risk of NE in children with AR. METHODS: A population-based cohort study was conducted among 327,928 children with AR and 327,601 non-AR controls between 2000 and 2012 in Taiwan...
October 3, 2018: International Forum of Allergy & Rhinology
Ahmed A Arif, Shelby D Veri
OBJECTIVE: The purpose of the study was to examine the relationship of maternal complications during pregnancy and prenatal exposures with childhood asthma among low-income families in Karachi, Pakistan. METHODS: Parents/guardians of children with and without asthma visiting a charity hospital were enrolled. Information about prenatal and perinatal exposures was collected. Univariable and multiple stepwise logistic regression analysis were conducted to explore the relationship of socio-demographic, maternal complications during pregnancy, access to prenatal care, and exposure to animals and pests while pregnant with childhood asthma...
October 1, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Christer Janson, Ane Johannessen, Karl Franklin, Cecilie Svanes, Linus Schiöler, Andrei Malinovschi, Thorarinn Gislason, Bryndis Benediktsdottir, Vivi Schlünssen, Rain Jõgi, Deborah Jarvis, Eva Lindberg
BACKGROUND: The aim of this investigation was to study change in adults over a 20 year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, life style and sleep related variables. METHOD: Adults 20-44 years of age, 6085 women and 5184 men, were randomly selected from seven centres in Northern Europe and followed for 20 years. The number of participants in the first survey was 21,595 and 11,269 participated in all three surveys...
September 12, 2018: BMC Pulmonary Medicine
Konrad Guenter, Werner Cassel, Olaf Hildebrandt, Johannes Kroenig, Patrick Fischer, Andreas Weissflog, Claus Vogelmeier, Ulrich Koehler
INTRODUCTION:  Awareness of respiratory symptoms during day- and night-time is important for asthma control. Acoustic long-term recording offers a possibility to monitor symptoms objectively. In this prospective observational study frequency of night-time cough and wheezing was evaluated in patients with stable asthma. METHODS:  Night-time cough and wheezing were monitored by LEOSound lung sound monitor in 40 patients with stable asthma. Patients did not complain of respiratory problems during day- and nighttime, asthma control test was 23 points on average...
September 2018: Deutsche Medizinische Wochenschrift
Joanne Kavanagh, David J Jackson, Brian D Kent
PURPOSE OF REVIEW: There is a longstanding recognition of the detrimental effect of poorly controlled asthma on sleep, but recent years have seen a growing interest in how asthma and sleep may interact. This review examines the current evidence of relationships between asthma, sleep and sleep disorders. RECENT FINDINGS: Poor quality sleep and sleep disturbance is highly prevalent in asthmatic patients, and particularly in those with severe asthma. Impaired sleep quality correlates with worse asthma control and quality of life...
November 2018: Current Opinion in Pulmonary Medicine
K Guenter, T Boeselt, J Kroenig, O Hildebrandt, N Koehler, C Viniol, U Koehler
Medication management of asthma is based on level of asthma control. GINA defined criteria for asthma control include asking about daytime symptoms, limitation of activity, nocturnal symptoms/awakenings and need for reliever treatment. Effective asthma control is necessary for preventing exacerbations and worsening of lung function. Standardized and validated questionnaires such as asthma control test (ACT) help to assess the level of asthma control. Asthma control is classified as controlled, partially controlled or uncontrolled...
October 2018: Pneumologie
Susanna S S Ng, Tat-On Chan, Kin-Wang To, Ken K P Chan, Jenny Ngai, Wing-Ho Yip, Rachel L P Lo, Fanny W S Ko, David S C Hui
BACKGROUND AND OBJECTIVE: Unrecognized obstructive sleep apnoea syndrome (OSAS) may lead to poor asthma control despite optimal therapy. We assessed asthma control, airway responsiveness, daytime sleepiness and health status at baseline and 3 months after continuous positive airway pressure (CPAP) treatment among asthma patients with nocturnal symptoms and OSAS. METHODS: Patients with nocturnal asthma symptoms despite receiving at least moderate-dose inhaled corticosteroid and long-acting bronchodilators underwent a home sleep study using 'Embletta' portable diagnostic system...
July 10, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Javier Milagro, Eduardo Gil, Jesus Lazaro, Ville-Pekka Seppa, L Pekka Malmberg, Anna S Pelkonen, Anne Kotaniemi-Syrjanen, Mika J Makela, Jari Viik, Raquel Bailon
Asthma is a chronic lung disease that usually develops during childhood. Despite that symptoms can almost be controlled with medication, early diagnosis is desirable in order to reduce permanent airway obstruction risk. It has been suggested that abnormal parasympathetic nervous system (PSNS) activity might be closely related with the pathogenesis of asthma, and that this PSNS activity could be reflected in cardiac vagal control. In this work, an index to characterize the spectral distribution of the high frequency (HF) component of heart rate variability (HRV), named peakness ($\wp$), is proposed...
September 2018: IEEE Journal of Biomedical and Health Informatics
Elpis Hatziagorou, Eleana Kouroukli, Maria Galogavrou, Dafni Papanikolaou, Dr Despoina Terzi, Pinelopi Anagnostopoulou, Fotios Kirvassilis, Demosthenes B Panagiotakos, John Tsanakas
BACKGROUND: Inhaled Corticosteroids (ICS) are the cornerstone of asthma management in pediatric patients. However, in some cases, asthma is not adequately controlled on ICS alone. Long-acting beta2 -agonists (LABA) are one of the available additional therapies but their use has rarely been studied among children younger than 5 years. OBJECTIVE: The aim of this observational study was to evaluate the efficacy and safety of the combination of fluticasone propionate and salmeterol (FP/SA) in asthmatic children younger than 5 years of age...
June 29, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Magdalena Pawelec-Winiarz, Anna Brzecka
Both asthma and obstructive sleep apnea (OSA) syndrome are frequent diseases and their coexistence may implicate important consequences. The incidence of OSA syndrome among the patients with asthma is higher than in the general population, especially in the patients with nocturnal symptoms persisting despite treatment, in patients frequently admitted to hospital because of the exacerbations of asthma, and in obese patients. The causes of frequent coexistence of asthma and OSA syndrome are not fully elucidated...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
S J Wu, S Chen, B Chen, L Wang, X Zeng
Objective: The aim of this study is to evaluate the efficacy of standardized sublingual immunotherapy of allergic asthma with rhinitis in children between two different age groups. Method: Retrospective analysis of 250 patients with allergic asthma and rhinitis who received SLIT treatment. According to the age divided into younger children group (aged 3-6 years, 128 patients) and older children group (aged 7-13 years, 122 patients). Evaluate the asthma daytime, nocturnal symptom, medication score, VAS score and pulmonary function FEV1, PEF% level and rhinitis symptom and medication score before and after treatment of two groups of children...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Souheil Hallit, Benedicte Leynaert, Marie Christine Delmas, Steffi Rocchi, Jacques De Blic, Christophe Marguet, Emeline Scherer, Marie Noelle Dufourg, Corinne Bois, Gabriel Reboux, Laurence Millon, Marie Aline Charles, Chantal Raherison
OBJECTIVE: Different phenotypes of wheezing have been described to date but not in early life. We aim to describe wheezing phenotypes between the ages of two months and one year, and assess risk factors associated with these wheezing phenotypes in a large birth cohort. METHODS: We studied 18,041 infants from the ELFE (French Longitudinal Study of Children) birth cohort. Parents reported wheezing and respiratory symptoms at two and 12 months, and answered a complete questionnaire (exposure during pregnancy, parental allergy)...
2018: PloS One
Michelle F Huffaker, Michael Carchia, Bronwyn U Harris, William C Kethman, Todd E Murphy, Charlotte C D Sakarovitch, FeiFei Qin, David N Cornfield
RATIONALE: Asthma management depends on prompt identification of symptoms, which challenges both patients and providers. In asthma, a misapprehension of health between exacerbations can compromise compliance. Thus, there is a need for a tool that permits objective longitudinal monitoring without increasing the burden of patient compliance. OBJECTIVES: We sought to determine whether changes in nocturnal physiology are associated with asthma symptoms in pediatric patients...
August 1, 2018: American Journal of Respiratory and Critical Care Medicine
A P Kollmeier, A Greenspan, X L Xu, P E Silkoff, E S Barnathan, M J Loza, J Jiang, B Zhou, B Chen, R L Thurmond
BACKGROUND: The effects of H4 R antagonists in preclinical asthma models support the study of antagonists of the H4 R in the treatment of asthma in humans. JNJ-39758979 is a potent and highly selective oral H4 R antagonist. OBJECTIVE: We sought to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult patients with uncontrolled asthma. METHODS: One hundred and fifteen eligible patients were randomly assigned to JNJ-39758979 300 mg or placebo once daily for 12 weeks in this phase 2a, double-blind, multicenter, placebo-controlled study...
August 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
M Lu, M Wang, X Zhu, Y H Chen, W Z Yao
Here we reported a case of bronchial adenoid cystic carcinoma from Peking University Third Hospital. A 40-year-old female presented with dry cough for 1 year and nocturnal paroxysmal attacks of wheezing for 4 months. She was a non-smoker, and did not have past histories of asthma or allergy. On physical examination, no stridor, wheezing and cyanosis were present and the general appearance was good. The results of the laboratory analysis, including blood eosinophils count, immunoglobulin E level and chest X-ray were normal...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
E Cabon, F Rey, D Tissier-Ducamp, M J Del Volgo, S Delliaux, M Bues-Charbit, D Charpin, F Brégeon
There are few prospective studies available on the development of delayed symptoms following challenge tests with methacholine (MCT) at the currently recommended doses. The objective of this study was to describe the nature and frequency of respiratory symptoms suggestive of bronchospasm developing within 24hours after a MCT. The study was offered to adult patients who underwent MCT seen consecutively between June and October 2015. Following the test, a questionnaire adapted from the GINA asthma control questionnaire bearing on diurnal and nocturnal symptoms (cough, dyspnoea, wheeze and tightness), was delivered to the patient and the replies collected by telephone 24hours later...
March 2018: Revue des Maladies Respiratoires
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