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Nocturnal asthma

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https://www.readbyqxmd.com/read/28503097/asthma-management-among-allergists-in-italy-results-from-a-survey
#1
M S Magnoni, M Caminati, G W Canonica, F Arpinelli, A Rizzi, G Senna
BACKGROUND: In Europe more than 50% of asthmatic treated patients have not well-controlled asthma. Asthma affects about 2.5 million of patients in Italy. AIMS AND OBJECTIVES: The present survey aims at investigating how Italian allergists approach asthmatic patients, in order to highlight pitfalls and unmet needs concerning real-life asthma management. METHODS: An anonymous 16 item web questionnaire was available (April-October 2015) to all allergists who visited the web site of SIAAIC (Società Italiana di Allergologia, Asma Immunologia Clinica)...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28488945/tropical-pulmonary-eosinophilia-masquerading-as-asthma-in-a-5-year-old-girl
#2
Shivani Randev, Pankaj Kumar, Prabhjot Dhillon, Geetanjali Jindal, Vishal Guglani
Tropical pulmonary eosinophilia (TPE) is an exaggerated immunological response to filarial antigens mainly seen in adults in endemic areas and is uncommonly reported in children. The diagnosis is frequently delayed as it mimics asthma clinically, while the chest radiograph might show miliary mottling which is often confused with that in pulmonary tuberculosis. A 5-year-old girl presented with episodes of nocturnal cough, wheeze, low grade fever and breathlessness for the previous 4 months and was being treated for asthma...
May 10, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28479021/what-keeps-children-with-cystic-fibrosis-awake-at-night
#3
Moya Vandeleur, Lisa M Walter, David S Armstrong, Philip Robinson, Gillian M Nixon, Rosemary S C Horne
BACKGROUND: Sleep disturbance is common in children with cystic fibrosis (CF) however there are limited studies investigating the causes for poor sleep quality. In a cross sectional observational study we aimed to evaluate the clinical correlates of sleep disturbance in this population. METHODS: Children with CF (7-18years) free from pulmonary exacerbation completed medical review, overnight oximetry, the OSA-18 and 14days of actigraphy recordings with a sleep diary...
May 4, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28465694/visual-analogue-scale-vas-as-a-monitoring-tool-for-daily-changes-in-asthma-symptoms-in-adolescents-a-prospective-study
#4
Hyekyun Rhee, Michael Belyea, Jennifer Mammen
BACKGROUND: Success in asthma management hinges on patients' competency to detect and respond to ever-changing symptom severity. Thus, it is crucial to have reliable, simple, and sustainable methods of symptom monitoring that can be readily incorporated into daily life. Although visual analogue scale (VAS) has been considered as a simple symptom assessment method, its utility as a daily symptom monitoring tool in adolescents is unknown. This study was to determine the concurrent validity of VAS in capturing diurnal changes in symptoms and to examine the relationships between VAS and asthma control and pulmonary function...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28391549/disease-burden-of-mild-asthma-findings-from-a-cross-sectional-real-world-survey
#5
Bo Ding, Mark Small
INTRODUCTION: Most asthma patients have mild disease, although the burden of mild asthma is not well understood nor studied. Some evidence suggests that many patients with mild asthma experience suboptimal symptom control and exacerbations. This study characterizes the burden of illness and treatment patterns among patients with a confirmed diagnosis of mild asthma, defined as GINA Step 1 or Step 2, and residing in China, France, Germany, Italy, Japan, Spain, the United Kingdom, or the United States...
May 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28197893/gender-differences-in-clinical-and-polysomnographic-features-of-obstructive-sleep-apnea-a-clinical-study-of-2827-patients
#6
Ozen K Basoglu, Mehmet Sezai Tasbakan
PURPOSE: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women. METHODS: Differences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared. RESULTS: In female OSA patients, age (56.1 ± 9.7 vs. 50.4 ± 11...
February 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28036050/environmental-determinants-of-bronchial-asthma-among-saudi-school-children-in-southwestern-saudi-arabia
#7
Jobran M Alqahtani, Ahmed M Asaad, Nabil J Awadalla, Ahmed A Mahfouz
The aim here was to study the possible environmental and dietary determinants of asthma among school-aged children in Southwestern Saudi Arabia. In a cross-sectional study on a representative sample in Najran in Southwestern Saudi Arabia using an Arabic version of the modified ISAAC Phase III, parent-administered questionnaire data were collected. Skin prick tests (SPTs) were performed. The study included 1700 school children, out of them 468 (27.5%) were diagnosed with, cases of bronchial asthma and 20.8% (353) reported a 12-month nocturnal cough (as a proxy of severe asthma)...
December 28, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27993293/effect-of-psychological-and-other-factors-on-quality-of-life-amongst-asthma-outpatients-in-lagos-nigeria
#8
Olufunke O Adeyeye, Tomilola A Adewumi, Abiodun O Adewuya
BACKGROUND: This study aimed to assess the effect of psychological and other possible factors associated with poor health related quality of life (HRQOL) in outpatient with asthma in Lagos, Nigeria. METHODS: Patients (n  = 201) recruited from the adult asthma outpatient clinic were assessed for sociodemographic and asthma related variables. Levels of social support (with Oslo 3-Item Social Support Scale), disability (with WHO Disability Assessment Scale) were assessed...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27923646/role-of-the-allergist-immunologist-and-upper-airway-allergy-in-sleep-disordered-breathing
#9
Dennis Shusterman, Fuad M Baroody, Timothy Craig, Samuel Friedlander, Talal Nsouli, Bernard Silverman
BACKGROUND: Sleep-disordered breathing in general and obstructive sleep apnea in particular are commonly encountered conditions in allergy practice. Physiologically, nasal (or nasopharyngeal) obstruction from rhinitis, nasal polyposis, or adenotonsillar hypertrophy are credible contributors to snoring and nocturnal respiratory obstructive events. Nevertheless, existing practice parameters largely relegate the role of the allergist to adjunctive treatment in cases of continuous positive airway pressure intolerance...
May 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27802882/respiratory-symptoms-and-fractional-exhaled-nitric-oxide-feno-among-students-in-penang-malaysia-in-relation-to-signs-of-dampness-at-school-and-fungal-dna-in-school-dust
#10
Dan Norbäck, Jamal Hisham Hashim, Zailina Hashim, Gui-Hong Cai, Vinoshini Sooria, Syazwan Aizat Ismail, Gunilla Wieslander
Few health studies exist on dampness and mould in schools in the tropics. We studied associations between fraction of exhaled nitric oxide (FeNO), respiratory symptoms and airway infections among students and dampness and fungal DNA in schools in Malaysia. A total of 368 randomly selected students from 32 classrooms in 8 secondary schools in Penang, Malaysia, participated (58% participation rate). Information on current respiratory symptoms and the home environment was collected by a standardised questionnaire...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27646537/respiratory-symptoms-sleep-disordered-breathing-and-biomarkers-in-nocturnal-gastroesophageal-reflux
#11
Össur Ingi Emilsson, Bryndís Benediktsdóttir, Ísleifur Ólafsson, Elizabeth Cook, Sigurður Júlíusson, Einar Stefán Björnsson, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, Ekaterina Mirgorodskaya, Evert Ljungström, Erna Sif Arnardóttir, Þórarinn Gíslason, Christer Janson, Anna-Carin Olin
BACKGROUND: Nocturnal gastroesophageal reflux (nGER) is associated with respiratory symptoms and sleep-disordered breathing (SDB), but the pathogenesis is unclear. We aimed to investigate the association between nGER and respiratory symptoms, exacerbations of respiratory symptoms, SDB and airway inflammation. METHODS: Participants in the European Community Respiratory Health Survey III in Iceland with nGER symptoms (n = 48) and age and gender matched controls (n = 42) were studied by questionnaires, exhaled breath condensate (EBC), particles in exhaled air (PEx) measurements, and a home polygraphic study...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27642150/-pulmonary-complications-of-sickle-cell-disease-in-children
#12
T Pincez, L Calamy, Z Germont, A Lemoine, A-A Lopes, A Massiot, J Tencer, C Thivent, A Hadchouel
Acute and chronic pulmonary complications are frequent in sickle cell disease (SCD), with different spectrum and characteristics in children and adults. Chronic hypoxia is frequent and plays a role in several respiratory complications in SCD. Furthermore, hypoxia has been associated with a higher risk of cerebral ischemia. Despite differing oxygen affinity between hemoglobin A and S, standard pulse oximetry was shown to be accurate in diagnosing hypoxia in SCD patients. Whereas acute hypoxia management is similar to non-SCD patients, chronic hypoxia treatment is mainly based on a transfusion program rather than long-term oxygen therapy...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27609845/long-term-health-effects-of-the-eyjafjallaj%C3%A3-kull-volcanic-eruption-a-prospective-cohort-study-in-2010-and-2013
#13
Heidrun Hlodversdottir, Gudrun Petursdottir, Hanne Krage Carlsen, Thorarinn Gislason, Arna Hauksdottir
OBJECTIVES: To examine the long-term development of physical and mental health following exposure to a volcanic eruption. DESIGN: Population-based prospective cohort study. SETTING: In spring 2010, the Icelandic volcano Eyjafjallajökull erupted. Data were collected at 2 time points: in 2010 and 2013. PARTICIPANTS: Adult residents in areas close to the Eyjafjallajökull volcano (N=1096), divided according to exposure levels, and a non-exposed sample (n=475), with 80% participation rate in 2013...
September 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27589676/biomass-fuel-exposure-and-asthma-symptoms-among-rural-school-children-in-nigeria
#14
Oluwafemi Oluwole, Ganiyu O Arinola, Dezheng Huo, Christopher O Olopade
BACKGROUND: Approximately 70% of rural Nigerian households rely on biomass fuels for cooking. The International Study of Asthma and Allergies in Childhood (ISAAC) estimates the prevalence of current wheeze among children in Nigeria to have risen from 10.7% in 1999 to approximately 20% in 2014. OBJECTIVE: To examine the effects of biomass smoke exposure on asthma symptom prevalence in rural children in Nigeria. METHODS: We conducted a cross-sectional survey in rural communities in Nigeria...
May 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27551858/estimating-pediatric-asthma-prevalence-in-rural-senegal-a-cross-sectional-survey
#15
Laura G Hooper, Yakou Dieye, Assane Ndiaye, Aldiouma Diallo, Vincent S Fan, Kathleen M Neuzil, Justin R Ortiz
RATIONALE: In Senegal, the prevalence of childhood asthma and utilization of appropriate asthma therapies is unknown. METHODOLOGY: We used the International Study of Asthma and Allergies in Childhood (ISAAC) survey instrument to assess childhood respiratory health in rural Senegal. We interviewed the caregivers of children aged 5 through 8 years of age in the four largest Niakhar villages in August 2012. RESULTS: We interviewed 1,103 primary caregivers for 1,513 children, representing 91% of all age-eligible children in the study area...
August 23, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27519919/nocturnal-emergency-department-visits-duration-of-symptoms-and-risk-of-hospitalisation-among-adults-with-asthma-exacerbations-a-multicentre-observational-study
#16
Hideto Yasuda, Yusuke Hagiwara, Hiroko Watase, Kohei Hasegawa
OBJECTIVES: We sought to compare the characteristics of patients with asthma presenting to the emergency department (ED) during the night-time with those of patients presenting at other times of the day, and to determine whether the time of ED presentation is associated with the risk of hospitalisation. DESIGN AND SETTING: A multicentre chart review study of 23 EDs across Japan. PARTICIPANTS: Patients aged 18-54 years with a history of physician-diagnosed asthma, presented to the ED between January 2009 and December 2011 OUTCOME MEASURES: The outcome of interest was hospitalisation, including admissions to an observation unit, inpatient unit and intensive care unit...
August 12, 2016: BMJ Open
https://www.readbyqxmd.com/read/27487239/a-passenger-strand-variant-in-mir-196a2-contributes-to-asthma-severity-in-children-and-adolescents-a-preliminary-study
#17
COMPARATIVE STUDY
Mohammad H Hussein, Eman A Toraih, Nagwa M Aly, Eman Riad, Manal S Fawzy
There is emerging evidence to support the role of microRNAs in allergic airway diseases and inflammation. Genetic variants in microRNA genes might affect microRNA-mediated cell regulation. This preliminary study was designed to investigate the association of the microRNA-196a2 rs11614913 (C/T) polymorphism with susceptibility to asthma and clinical outcomes in children and adolescents. Genotyping of rs11614913 polymorphism was determined in 96 patients with bronchial asthma (6-18 years of age) and 96 unrelated controls, using real-time polymerase chain reaction technology...
August 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/27402309/sleep-quality-and-daytime-sleepiness-in-patients-with-copd-and-asthma
#18
Marija Vukoja, Ivan Kopitovic, Dragana Milicic, Olivera Maksimovic, Zora Pavlovic-Popovic, Miroslav Ilic
INTRODUCTION: Nocturnal symptoms are common and important in both asthma and COPD but the relationship between sleep quality and diseases' characteristics has not been fully studied. OBJECTIVE: To compare sleep quality and daytime sleepiness in asthma and COPD patients and to explore its relation to diseases' characteristics. METHODS: In this cross-sectional study we examined 217 consecutive asthma and COPD patients who underwent pulmonary function tests at The Center for Pathophysiology of Breathing and Sleep Medicine of The Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia between July 2014 and January 2015...
July 12, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27398992/effect-of-continuous-positive-airway-pressure-on-airway-reactivity-in-asthma-a-randomized-sham-controlled-clinical-trial
#19
Janet T Holbrook, Elizabeth A Sugar, Robert H Brown, Lea T Drye, Charles G Irvin, Alan R Schwartz, Robert S Tepper, Robert A Wise, Razan Z Yasin, Michael F Busk
RATIONALE: Studies have demonstrated that application of stress suppresses airway smooth muscle contractility. In animal models of asthma, continuous positive airway pressure (CPAP) reduced airway reactivity. Short-term studies of CPAP in patients with asthma showed reductions in airway reactivity. OBJECTIVES: To evaluate whether nocturnal CPAP decreased the provocative concentration of methacholine to reduce FEV1 by 20% (PC20). METHODS: One hundred ninety-four individuals with asthma were randomized (1:1:1) to use CPAP with warmed, filtered, humidified air at night at pressures either less than 1 cm H2O (sham) or at 5 cm H2O or 10 cm H2O...
November 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27385593/the-relationship-between-glutathione-s-transferase-p1-and-beta-2-adrenoreceptor-genotypes-with-asthmatic-patients-in-the-turkish-population
#20
Cetin Kaymak, Neslihan Aygun Kocabas, Nesrin Aydın, Derya Oztuna, Ali Esat Karakaya
BACKGROUND: Individual differences in the activity of enzymes that metabolize xenobiotics can impact health and disease. Beta-2 adrenoreceptor (ADRB2) is a functional G-coupled protein expressed in the vascular endothelium of lungs, alveolar walls, and the ganglions of cholinergic nerves which induces bronchodilation in response to catecholamines. Glutathione S-Transferase-P1 (GSTP1) is a candidate pi class GST gene, which controls pi class glutathione S-transferase activity. AIMS: In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma...
September 2016: Genetic Testing and Molecular Biomarkers
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