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Nocturnal asthma

Össur Ingi Emilsson, Bryndís Benediktsdóttir, Ísleifur Ólafsson, Elizabeth Cook, Sigurður Júlíusson, Einar Stefán Björnsson, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, Ekaterina Mirgorodskaya, Evert Ljungström, Erna Sif Arnardóttir, Þórarinn Gíslason, Christer Janson, Anna-Carin Olin
BACKGROUND: Nocturnal gastroesophageal reflux (nGER) is associated with respiratory symptoms and sleep-disordered breathing (SDB), but the pathogenesis is unclear. We aimed to investigate the association between nGER and respiratory symptoms, exacerbations of respiratory symptoms, SDB and airway inflammation. METHODS: Participants in the European Community Respiratory Health Survey III in Iceland with nGER symptoms (n = 48) and age and gender matched controls (n = 42) were studied by questionnaires, exhaled breath condensate (EBC), particles in exhaled air (PEx) measurements, and a home polygraphic study...
2016: Respiratory Research
T Pincez, L Calamy, Z Germont, A Lemoine, A-A Lopes, A Massiot, J Tencer, C Thivent, A Hadchouel
Acute and chronic pulmonary complications are frequent in sickle cell disease (SCD), with different spectrum and characteristics in children and adults. Chronic hypoxia is frequent and plays a role in several respiratory complications in SCD. Furthermore, hypoxia has been associated with a higher risk of cerebral ischemia. Despite differing oxygen affinity between hemoglobin A and S, standard pulse oximetry was shown to be accurate in diagnosing hypoxia in SCD patients. Whereas acute hypoxia management is similar to non-SCD patients, chronic hypoxia treatment is mainly based on a transfusion program rather than long-term oxygen therapy...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Heidrun Hlodversdottir, Gudrun Petursdottir, Hanne Krage Carlsen, Thorarinn Gislason, Arna Hauksdottir
OBJECTIVES: To examine the long-term development of physical and mental health following exposure to a volcanic eruption. DESIGN: Population-based prospective cohort study. SETTING: In spring 2010, the Icelandic volcano Eyjafjallajökull erupted. Data were collected at 2 time points: in 2010 and 2013. PARTICIPANTS: Adult residents in areas close to the Eyjafjallajökull volcano (N=1096), divided according to exposure levels, and a non-exposed sample (n=475), with 80% participation rate in 2013...
2016: BMJ Open
Oluwafemi Oluwole, Ganiyu O Arinola, Dezheng Huo, Christopher O Olopade
BACKGROUND: Approximately 70% of rural Nigerian households rely on biomass fuels for cooking. The International Study of Asthma and Allergies in Childhood (ISAAC) estimates the prevalence of current wheeze among children in Nigeria to have risen from 10.7% in 1999 to approximately 20% in 2014. OBJECTIVE: To examine the effects of biomass smoke exposure on asthma symptom prevalence in rural children. METHODS: We conducted a cross-sectional survey in rural communities in Nigeria...
September 2, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Laura G Hooper, Yakou Dieye, Assane Ndiaye, Aldiouma Diallo, Vincent S Fan, Kathleen M Neuzil, Justin R Ortiz
RATIONALE: In Senegal, the prevalence of childhood asthma and utilization of appropriate asthma therapies is unknown. METHODOLOGY: We used the International Study of Asthma and Allergies in Childhood (ISAAC) survey instrument to assess childhood respiratory health in rural Senegal. We interviewed the caregivers of children aged 5 through 8 years of age in the four largest Niakhar villages in August 2012. RESULTS: We interviewed 1,103 primary caregivers for 1,513 children, representing 91% of all age-eligible children in the study area...
August 23, 2016: Pediatric Pulmonology
Hideto Yasuda, Yusuke Hagiwara, Hiroko Watase, Kohei Hasegawa
OBJECTIVES: We sought to compare the characteristics of patients with asthma presenting to the emergency department (ED) during the night-time with those of patients presenting at other times of the day, and to determine whether the time of ED presentation is associated with the risk of hospitalisation. DESIGN AND SETTING: A multicentre chart review study of 23 EDs across Japan. PARTICIPANTS: Patients aged 18-54 years with a history of physician-diagnosed asthma, presented to the ED between January 2009 and December 2011 OUTCOME MEASURES: The outcome of interest was hospitalisation, including admissions to an observation unit, inpatient unit and intensive care unit...
2016: BMJ Open
Mohammad H Hussein, Eman A Toraih, Nagwa M Aly, Eman Riad, Manal S Fawzy
There is emerging evidence to support the role of microRNAs in allergic airway diseases and inflammation. Genetic variants in microRNA genes might affect microRNA-mediated cell regulation. This preliminary study was designed to investigate the association of the microRNA-196a2 rs11614913 (C/T) polymorphism with susceptibility to asthma and clinical outcomes in children and adolescents. Genotyping of rs11614913 polymorphism was determined in 96 patients with bronchial asthma (6-18 years of age) and 96 unrelated controls, using real-time polymerase chain reaction technology...
August 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
Marija Vukoja, Ivan Kopitovic, Dragana Milicic, Olivera Maksimovic, Zora Pavlovic-Popovic, Miroslav Ilic
INTRODUCTION: Nocturnal symptoms are common and important in both asthma and COPD but the relationship between sleep quality and diseases' characteristics has not been fully studied. OBJECTIVE: To compare sleep quality and daytime sleepiness in asthma and COPD patients and to explore its relation to diseases' characteristics. METHODS: In this cross-sectional study we examined 217 consecutive asthma and COPD patients who underwent pulmonary function tests at The Center for Pathophysiology of Breathing and Sleep Medicine of The Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia between July 2014 and January 2015...
July 12, 2016: Clinical Respiratory Journal
Janet T Holbrook, Elizabeth A Sugar, Robert H Brown, Lea T Drye, Charles G Irvin, Alan R Schwartz, Robert S Tepper, Robert A Wise, Razan Z Yasin, Michael F Busk
RATIONALE: Studies have demonstrated that application of stress suppresses airway smooth muscle contractility. In animal models of asthma, continuous positive airway pressure (CPAP) reduced airways reactivity. Short-term studies of CPAP in asthma patients showed reductions in airways reactivity. OBJECTIVES: To evaluate whether nocturnal CPAP decreased the provocative concentration of methacholine to reduce FEV1 by 20% (PC20). METHODS: 194 asthmatics were randomized (1:1:1) to use CPAP with warmed, filtered, humidified air at night at pressures less than 1cmH2O (sham), 5cmH2O, or 10cmH2O...
July 11, 2016: Annals of the American Thoracic Society
Cetin Kaymak, Neslihan Aygun Kocabas, Nesrin Aydın, Derya Oztuna, Ali Esat Karakaya
BACKGROUND: Individual differences in the activity of enzymes that metabolize xenobiotics can impact health and disease. Beta-2 adrenoreceptor (ADRB2) is a functional G-coupled protein expressed in the vascular endothelium of lungs, alveolar walls, and the ganglions of cholinergic nerves which induces bronchodilation in response to catecholamines. Glutathione S-Transferase-P1 (GSTP1) is a candidate pi class GST gene, which controls pi class glutathione S-transferase activity. AIMS: In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma...
September 2016: Genetic Testing and Molecular Biomarkers
V Sanz de Burgoa, J Rejas, P Ojeda
BACKGROUND AND OBJECTIVE: Nocturnal asthma symptoms are associated with poor sleep quality, excessive daytime sleepiness, and poor daytime functioning. The aim of this study was to describe self-perceived sleep quality and quantity in asthmatic adults in a real-world setting according to different determinants of patient health status. METHODS: A cross-sectional, observational, seasonal, multiwave survey was designed. Allergists nationwide were asked to consecutively survey adult asthmatics aged 18 to 65 years, evenly distributed by seasons and asthma severity (Global Initiative for Asthma criteria)...
2016: Journal of Investigational Allergology & Clinical Immunology
Kota Hirai, Mayumi Enseki, Hideyuki Tabata, Mariko Nukaga, Shinichi Matsuda, Masahiko Kato, Hiroyuki Furuya, Hiroyuki Mochizuki
BACKGROUND: Although a number of patients with asthma report experiencing persistent cough during sleep, it has not yet been objectively investigated. OBJECTIVE: To classify cough severity and evaluate a characteristic pattern of cough frequency in children with asthma using an objective cough monitoring system. METHODS: An objective cough monitoring system that specialized in children was used to measure cough frequency and nocturnal cough patterns...
August 2016: Annals of Allergy, Asthma & Immunology
Caroline C Horner, Courtney Dula, Leonard B Bacharier, Jane M Garbutt, Carlos Gonzalez, Elena Deych, William D Shannon, Robert C Strunk
No abstract text is available yet for this article.
April 21, 2016: Journal of Allergy and Clinical Immunology
Marly Sarmanho Freitas, Fernanda de Córdoba Lanza, Julius Caesar Soares Monteiro, Dirceu Solé
BACKGROUND: The prevalence of rhinitis has been reported to be higher in urban areas. OBJECTIVE: To determine the prevalence of rhinitis in schoolchildren who lived on two islands in the Brazilian Amazon, including a rural island and an urban island, and to identify the associated risk factors. METHODS: Four hundred children (200 per island) were evaluated by using the International Study of Asthma and Allergy in Childhood standard written questionnaire (rhinitis module)...
May 2016: American Journal of Rhinology & Allergy
Roberto Stirbulov, Nilceia Lopes da Silva, Sarah Cristina Oliveira Machado Maia, Eduardo Carvalho-Netto, Luciene Angelini
INTRODUCTION: Severe asthma is characterized by frequent exacerbations, symptoms limiting daily activities and nocturnal symptoms. It requires the continuous use of medications, at high doses, and, sometimes, continuous use of oral corticosteroids, representing a significant burden to health system and society. This systematic review sought to address economic data related to severe asthma in Brazil. METHOD: In June 2014, electronic searches were conducted to identify relevant publications...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Ville-Pekka Seppä, Anna S Pelkonen, Anne Kotaniemi-Syrjänen, Jari Viik, Mika J Mäkelä, L Pekka Malmberg
Lung function variability is a fundamental feature of asthma but has been difficult to quantify in children due to methodological limitations. We assessed the feasibility and clinical implications of overnight flow variability measurement at home using impedance pneumography in young children.44 children aged 3-7 years with recurrent or persistent lower airway symptoms were recruited. Patients were divided into high- or lower-risk groups (HR and LR groups) based on their risk of asthma (modified Asthma Predictive Index), and a third group was formed of children who had a history of wheeze and who were treated with inhaled corticosteroids (ICS group)...
June 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Camille Taillé, Anny Rouvel-Tallec, Maria Stoica, Claire Danel, Monique Dehoux, Viviana Marin-Esteban, Marina Pretolani, Michel Aubier, Marie-Pia d'Ortho
BACKGROUND: Obstructive sleep apnoea (OSA) is frequently observed in severe asthma but the causal link between the 2 diseases remains hypothetical. The role of OSA-related systemic and airway neutrophilic inflammation in asthma bronchial inflammation or remodelling has been rarely investigated. The aim of this study was to compare hallmarks of inflammation in induced sputum and features of airway remodelling in bronchial biopsies from adult patients with severe asthma with and without OSA...
2016: PloS One
Saleh Al-Harbi, Adel S Al-Harbi, Abdullah Al-Khorayyef, Mansour Al-Qwaiee, Abdullah Al-Shamarani, Wafa Al-Aslani, Hayat Kamfar, Osama Felemban, Mohammed Barzanji, Naser Al-Harbi, Ruqaia Dhabab, Mohammed Ahmed Al-Omari, Abdullah Yousef
OBJECTIVE: Assessing the knowledge and awareness of the Saudi society about bronchial asthma in children. METHODS: Structured questionnaires were randomly distributed to 1039 Saudi Arabians in May 2014 at Jeddah, Riyadh, and Dammam. RESULTS: The awareness of bronchial asthma questions showed that 67% of total sample thought that it could be a fatal disease, and only 13.2% thought that there is a difference between bronchial asthma and chest allergies in children...
January 2016: Annals of Thoracic Medicine
Patricia Dahan, José de Bessa, Dayana Maria de Oliveira, Camila Couto Gomes, Julio Cesar Cardoso, Isabela Teixeira Macedo, Mariana de Almeida Belo, André Avarese de Figueiredo, José Murillo B Netto
PURPOSE: Enuresis, sleep respiratory disorders and asthma compromise the quality of sleep in children and may occur in association with each other. An association between sleep respiratory disorders and enuresis has already been demonstrated. According to united airways disease abnormalities of the upper and lower airways may coexist. A child who wheezes has a greater chance of snoring and having obstructive sleep apnea. Since asthma and sleep respiratory disorders may be associated, and sleep respiratory disorders are associated with enuresis, we determined the possibility of an association between asthma and enuresis...
April 2016: Journal of Urology
Nancy Cantey Banasiak
The Centers for Disease Control and Prevention reports that 9.5% of children have been diagnosed with asthma. Sleep disturbances affect 20% to 30% of the pediatric population. The prevalence of nocturnal symptoms of asthma is high, and most children regularly experience nighttime symptoms. Sleep is important for growth and development, and untreated sleep disturbances have adverse effects on school performance, mental health, physical health, and functioning. This review will explore the relationship between asthma and sleep disturbances...
November 2016: Journal of Pediatric Health Care
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