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Gary P Wormser, Claudia R Molins, Andrew Levin, Susan C Lipsett, Lise E Nigrovic, Martin E Schriefer, John A Branda
To diagnose Lyme disease, a two-tier testing algorithm is used in which supplemental IgM and IgG immunoblots to detect antibody to Borrelia burgdorferi are reflexively performed if a first-tier assay, such as a whole-cell sonicate-based enzyme immunoassay (WCS EIA), is reactive. Recent data suggest that equal specificity is found by substituting the C6 peptide EIA for immunoblots. In this study using 3956 control sera, we demonstrated that although this two-tier testing algorithm does significantly improve diagnostic specificity compared with each of the EIAs individually, the WCS EIA and the C6 peptide EIA are not independent tests...
February 16, 2018: Diagnostic Microbiology and Infectious Disease
Anne-Lise Mariet, Anne-Véronique Walter-Simonnet, Frédéric Gimbert, Christophe Cloquet, Carole Bégeot
Iron mining activities in the Bruche valley (Vosges Mountains, France) date historically from the Roman period to the mid-nineteenth century. The geochemical and palynological study of a core from the peat bog of Le Champ du Feu allows highlighting impacts of these activities over the past millennium. Trace metal contamination is recorded for lead (Pb), arsenic, zinc, and antimony during the Middle Ages, the sixteenth century, and from cal. AD 1750-1900, with several sources distinguished by Pb isotope analyses...
March 17, 2018: Ambio
João Henriques, Lise Arleth, Kresten Lindorff-Larsen, Marie Skepö
Solution techniques such as small-angle X-ray scattering (SAXS) play a central role in structural studies of intrinsically disordered proteins (IDPs), yet, due to low-resolution, it is generally necessary to combine SAXS with additional experimental sources of data and to use molecular simulations. Computational methods for the calculation of theoretical SAXS intensity profiles can be separated into two groups, depending on whether the solvent is modeled implicitly as continuous electron density or considered explicitly...
March 13, 2018: Journal of Molecular Biology
Antoine Abou Jaoude, Lise Badiqué, Mohamed Mlih, Sara Awan, Sunning Guo, Alexandre Lemle, Clauda Abboud, Sophie Foppolo, Lionel Host, Jérôme Terrand, Hélène Justiniano, Joachim Herz, Rachel L Matz, Philippe Boucher
ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the role of endothelial ShcA in atherosclerotic lesion formation. We found that atherosclerosis progression was markedly attenuated in mice deleted for ShcA in endothelial cells, that macrophage content was reduced at the sites of lesions, and that adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) were severely reduced...
March 14, 2018: Scientific Reports
Eirini Karyotaki, Lise Kemmeren, Heleen Riper, Jos Twisk, Adriaan Hoogendoorn, Annet Kleiboer, Adriana Mira, Andrew Mackinnon, Björn Meyer, Cristina Botella, Elizabeth Littlewood, Gerhard Andersson, Helen Christensen, Jan P Klein, Johanna Schröder, Juana Bretón-López, Justine Scheider, Kathy Griffiths, Louise Farrer, Marcus J H Huibers, Rachel Phillips, Simon Gilbody, Steffen Moritz, Thomas Berger, Victor Pop, Viola Spek, Pim Cuijpers
BACKGROUND: Little is known about potential harmful effects as a consequence of self-guided internet-based cognitive behaviour therapy (iCBT), such as symptom deterioration rates. Thus, safety concerns remain and hamper the implementation of self-guided iCBT into clinical practice. We aimed to conduct an individual participant data (IPD) meta-analysis to determine the prevalence of clinically significant deterioration (symptom worsening) in adults with depressive symptoms who received self-guided iCBT compared with control conditions...
March 15, 2018: Psychological Medicine
Mads Ryø Jochumsen, Michael Alle Madsen, Lise Gammelgaard, Kirsten Bouchelouche
A 75-year-old man with recently diagnosed high-risk prostate cancer was referred for primary staging with Ga-prostate-specific membrane antigen (PSMA) PET/CT. The scan revealed intense Ga-PSMA uptake in a lumbar osteophyte on the right side of level L2/L3, whereas several other spinal osteophytes showed no Ga-PSMA uptake. MRI findings in the L3 vertebra was consistent with a benign Modic type 1 lesion, but MRI showed no signs of malignancy in the osteophyte with high Ga-PMSA uptake. This case presents an osteophyte as an addition to the list of potential benign pitfalls to be aware of when interpreting Ga-PSMA PET/CT...
March 13, 2018: Clinical Nuclear Medicine
Aakash Chawade, Rita Armoniené, Gunilla Berg, Gintaras Brazauskas, Gunilla Frostgård, Mulatu Geleta, Andrii Gorash, Tina Henriksson, Kristiina Himanen, Anne Ingver, Eva Johansson, Lise Nistrup Jørgensen, Mati Koppel, Reine Koppel, Pirjo Makela, Rodomiro Ortiz, Wieslaw Podyma, Thomas Roitsch, Antanas Ronis, Jan T Svensson, Pernilla Vallenback, Martin Weih
Baltic Sea is one of the largest brackish water bodies in the world. Eutrophication is a major concern in the Baltic Sea due to the leakage of nutrients to the sea with agriculture being the primary source. Wheat (Triticum aestivum L.) is the most widely grown crop in the countries surrounding the Baltic Sea and thus promoting sustainable agriculture practices for wheat cultivation will have a major impact on reducing pollution in the Baltic Sea. This approach requires identifying and addressing key challenges for sustainable wheat production in the region...
March 14, 2018: Physiologia Plantarum
Signe Østergaard, Anne-Mette Hvas, Lise Medrud, Jens Fuglsang
No abstract text is available yet for this article.
February 2018: Hämostaseologie
Glenwood D Goss, Everett E Vokes, Michael S Gordon, Leena Gandhi, Kyriakos P Papadopoulos, Drew W Rasco, JuDee S Fischer, Katharine L Chu, William W Ames, Rajendar K Mittapalli, Ho-Jin Lee, Jiewei Zeng, Lisa A Roberts-Rapp, Lise I Loberg, Peter J Ansell, Edward B Reilly, Christopher J Ocampo, Kyle D Holen, Anthony W Tolcher
BACKGROUND: Epidermal growth factor receptor (EGFR) alterations are associated with multiple cancers. Current EGFR-directed therapies have led to increased efficacy but are associated with specific side effects. The antibody-drug conjugate depatuxizumab mafodotin (depatux-m) targets EGFR with a monoclonal antibody linked to a cytotoxin, and is highly tumor-specific. METHODS: This phase 1/2 study evaluated the safety, pharmacokinetics, and efficacy of depatux-m in patients who had advanced solid tumors with known wild-type EGFR overexpression, amplification, or mutated EGFR variant III...
March 13, 2018: Cancer
Geetanjali D Datta, Alexandra Blair, Marie-Pierre Sylvestre, Lise Gauvin, Mylene Drouin, Marie-Helene Mayrand
In Canada, over 40% of invasive cervical cancers occur among women who have never been screened. Although 12% of Canadian women have never been screened, this number can be as high as 43% among certain social groups. Little is published on factors associated with screening uptake and inequalities among women residing in Quebec. Four waves of the Canadian Community Health Survey (2003, 2005, 2008, 2012, N = 6393) were utilized to assess lifetime screening and screening in the previous 3 years among women residing in Montreal...
March 7, 2018: Preventive Medicine
Jeanette Wassar Kirk, Ann Christine Bodilsen, Tine Tjørnhøj-Thomsen, Mette Merete Pedersen, Thomas Bandholm, Rasmus Skov Husted, Lise Kronborg Poulsen, Janne Petersen, Ove Andersen, Per Nilsen
INTRODUCTION: Older medical patients (>65 years) represent 54% of the admissions to Danish medical and emergency departments. Acute admissions and bed-rest during hospitalisation are independent risk factors for death and dependency in older patients. Even short hospitalisations are associated with increased dependency in activities of daily living after discharge. Interventions that increase mobility during hospitalisation are therefore important. The purpose of this protocol is to describe the intervention design of the WALK-Copenhagen project, aimed at increasing 24 hours mobility in older medical patients during acute hospitalisations and following discharge...
March 8, 2018: BMJ Open
Carolina Pérez-Ferrer, Abbygail Jaccard, Andre Knuchel-Takano, Lise Retat, Martin Brown, Vilma Kriaucioniene, Laura Webber
AIMS: The aim of this study was to project educational inequalities in obesity and smoking prevalence to 2050 based on past obesity and smoking trends by education level. METHODS: Data on obesity (body mass index ≥ 30) and smoking prevalence (current smokers) by education level (tertiary education and less than tertiary) from nationally representative cross-sectional surveys were collected for the following six countries participating in the Economics of Chronic Diseases project (EConDA): England, Finland, Lithuania, the Netherlands, Poland (obesity only) and Portugal (obesity only)...
March 1, 2018: Scandinavian Journal of Public Health
Rosa Cortese, Lise Magnollay, Carmen Tur, Khaled Abdel-Aziz, Anu Jacob, Floriana De Angelis, Marios C Yiannakas, Ferran Prados, Sebastien Ourselin, Tarek A Yousry, Frederik Barkhof, Olga Ciccarelli
OBJECTIVE: To assess the value of the central vein sign (CVS) on a clinical 3T scanner to distinguish between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). METHODS: Eighteen aquaporin-4-antibody-positive patients with NMOSD, 18 patients with relapsing-remitting MS, and 25 healthy controls underwent 3T MRI. The presence of a central vein in white matter lesions on susceptibility-weighted imaging, defined as a thin hypointense line or a small dot, was recorded...
March 7, 2018: Neurology
Christian Staehr, Lise Hangaard, Elena V Bouzinova, Sukhan Kim, Rajkumar Rajanathan, Peter Boegh Jessen, Nathan Luque, Zijian Xie, Karin Lykke-Hartmann, Shaun L Sandow, Christian Aalkjaer, Vladimir V Matchkov
Familial hemiplegic migraine type 2 (FHM2) is associated with inherited point-mutations in the Na,K-ATPase α2 isoform, including G301R mutation. We hypothesized that this mutation affects specific aspects of vascular function, and thus compared cerebral and systemic arteries from heterozygote mice bearing the G301R mutation (Atp1a2+/-G301R ) with wild type (WT). Middle cerebral (MCA) and mesenteric small artery (MSA) function was compared in an isometric myograph. Cerebral blood flow was assessed with Laser speckle analysis...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
Michelle L Lise, Talita S Baptista, Laura E Petersen, Moises E Bauer, Henrique L Staub
No abstract text is available yet for this article.
March 6, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Henrik Maagensen, Anders E Junker, Niklas R Jørgensen, Lise L Gluud, Filip K Knop, Tina Vilsbøll
Context: Non-alcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes (T2D) and vice versa, and both conditions are associated with an increased risk of fractures and altered bone turnover. While NAFLD patients typically suffer from decreased bone mineral density (BMD), T2D is associated with normal to high BMD. The pathophysiology is uncertain, but may involve the gut-bone axis. Objective: We investigated the influence of the gut on glucose-induced changes in plasma bone turnover markers in healthy controls and patients with T2D and/or biopsy-verified NAFLD...
March 1, 2018: Journal of Clinical Endocrinology and Metabolism
Thomas A W Bolton, Delphine Jochaut, Anne-Lise Giraud, Dimitri Van De Ville
To refine our understanding of autism spectrum disorders (ASD), studies of the brain in dynamic, multimodal and ecological experimental settings are required. One way to achieve this is to compare the neural responses of ASD and typically developing (TD) individuals when viewing a naturalistic movie, but the temporal complexity of the stimulus hampers this task, and the presence of intrinsic functional connectivity (FC) may overshadow movie-driven fluctuations. Here, we detected inter-subject functional correlation (ISFC) transients to disentangle movie-induced functional changes from underlying resting-state activity while probing FC dynamically...
March 5, 2018: Human Brain Mapping
Qu-Knafo Lise, Auregan-Giocanti Audrey
Purpose: To report a case of bilateral panuveitis with multifocal choroiditis associated with a systemic sarcoidosis unmasked by pembrolizumab. Case report: A 68-years old woman with a history of metastatic melanoma treated by pembrolizumab consulted for bilateral blurred vision. The ophthalmologic examination revealed a bilateral anterior uveitis with cells in the anterior chamber and granulomatous keratic precipitates, vitreous cells and multifocal choroiditis confirmed by indocyanine green angiography...
April 2017: American Journal of Ophthalmology Case Reports
Liyu Peng, Lise Appels, Haijia Su
This study investigated the synergistic effect of sodium citrate (SC; Na3 C3 H5 O(COO)3 ) and microwave (MW) treatment on the efficiency of the anaerobic digestion of excess sewage sludge. In terms of the methane yield, an increase of the digestion's efficiency was observed. Taking into account the cost for the MW energy supplied to the system, the optimum treatment conditions were a MW energy input of 20 MJ/kg TS and a SC concentration of 0.11 g/g TS, obtaining a methane yield of 218.88 ml/g VS, i.e...
March 1, 2018: Journal of Environmental Management
Anne-Kathrine Carstens, Lise Fensby, Luit Penninga
Appendicitis is the most common nonobstetric surgical disease during pregnancy. Appendicitis during pregnancy is associated with an increased risk of morbidity and perforation compared with the general population. Furthermore, it may cause preterm birth and fetal loss, and quick surgical intervention is the established treatment option in pregnant women with appendicitis. In Greenland, geographical distances are very large, and weather conditions can be extreme, and surgical care is not always immediately available...
January 2018: American Journal of Perinatology Reports
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