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Lise J Estcourt, Reem Malouf, Carolyn Doree, Marialena Trivella, Sally Hopewell, Janet Birchall
BACKGROUND: People with thrombocytopenia often require a surgical procedure. A low platelet count is a relative contraindication to surgery due to the risk of bleeding. Platelet transfusions are used in clinical practice to prevent and treat bleeding in people with thrombocytopenia. Current practice in many countries is to correct thrombocytopenia with platelet transfusions prior to surgery. Alternatives to platelet transfusion are also used prior surgery. OBJECTIVES: To determine the clinical effectiveness and safety of prophylactic platelet transfusions prior to surgery for people with a low platelet count...
September 17, 2018: Cochrane Database of Systematic Reviews
Lise Barlebo Ahlborn, Ida Viller Tuxen, Florent Mouliere, Savvas Kinalis, Ane Y Schmidt, Kristoffer Staal Rohrberg, Eric Santoni-Rugiu, Finn Cilius Nielsen, Ulrik Lassen, Christina Westmose Yde, Olga Oestrup, Morten Mau-Sorensen
Purpose: We evaluated longitudinal tracking of BRAF V600E in circulating cell-free DNA (cfDNA) as a marker of treatment response to BRAF inhibitor (BRAFi) combination therapies in non-melanoma solid tumors included in the Copenhagen Prospective Personalized Oncology (CoPPO) program. Experimental design: Patients with BRAF V600E-mutated tumors were treated with combination therapies including BRAFi. Quantification of mutant cfDNA from plasma was determined and correlated to clinical outcomes...
August 24, 2018: Oncotarget
Annemiek Leeman, Renée M F Ebisch, Annemieke Kasius, Remko P Bosgraaf, David Jenkins, Miekel M van de Sandt, Lise M A de Strooper, Daniëlle A M Heideman, Peter J F Snijders, Leon F A G Massuger, Ruud L M Bekkers, Chris J L M Meijer, Folkert J van Kemenade, Wim G V Quint, Willem J G Melchers
OBJECTIVE: HPV16/18 genotyping and detection of hypermethylation of human cell genes involved in cervical oncogenesis have shown promising results in triage of high-risk HPV (hrHPV)-screen positive women on cervical smears. These tests can be performed on self-samples, which contain cervical and vaginal cells. We studied whether a self-sample represents the hrHPV type causing the worst cervical lesion and whether any differences in hypermethylation of FAM19A4/miR124-2 exist between CIN lesions caused by different hrHPV types...
September 12, 2018: Gynecologic Oncology
Kristine Hole, Petra L Heiberg, Caroline Gjestad, Lise L Mehus, Øyvind Rø, Espen Molden
Recent studies have shown that the cytochrome P450 (CYP) 3A phenotype marker 4β-hydroxycholesterol/cholesterol (4βOHC/C) ratio is negatively correlated with body weight in healthy volunteers, and that obese patients have lower 4βOHC levels than healthy controls. However, 4βOHC/C ratio in underweight patients has yet to be reported. The aim of this study was to examine potential differences in CYP3A activity between underweight patients with anorexia nervosa and normal-weight volunteers by measuring plasma 4βOHC/C ratio...
October 2018: Pharmacology Research & Perspectives
Lise Graversen, Annette Haagerup, Brian N Andersen, Karin K Petersen, Vibike Gjørup, Gudrun Gudmundsdottir, Ida Vogel, Pernille A Gregersen
We present a girl born with a frontal bossing, short neck, bell-shaped thorax, short limbs with prominent joints, and a tail-like coccygeal appendage. Genetic screening of TRPV4 identified a novel de novo heterozygous missense variant. We believe the variant causes the severe form of metatropic dysplasia in this patient.
September 2018: Clinical Case Reports
Inger Lise N Bråte, Rachel Hurley, Karine Iversen, Jonny Beyer, Kevin V Thomas, Calin C Steindal, Norman W Green, Marianne Olsen, Amy Lusher
Microplastic (MP) contamination is ubiquitous in the environment and many species worldwide have been shown to contain MP. The ecological impact of MP pollution is still unknown, thus there is an urgent need for more knowledge. One key task is to identify species suitable as sentinels for monitoring in key eco-compartments, such as coastal waters. In Norway, mussels (Mytilus spp.) have been monitored for hazardous contaminants through OSPAR since 1981. Norway has the longest coastline in Europe and adding MP to the Norwegian Mussel Watch is therefore important in a European and global context...
August 28, 2018: Environmental Pollution
Louis Viannay, Julie Haesebaert, Fannie Florin, Roberto Riva, Laura Mechtouff, Benjamin Gory, Elodie Ong, Paul-Emile Labeyrie, Laurent Derex, Marc Hermier, Leila Chamard, Lise-Prune Berner, Roxana Ameli, Yves Berthezène, Francis Turjman, Norbert Nighoghossian, Tae-Hee Cho
Introduction: Randomized trials (RT) have recently validated the superiority of thrombectomy over standard medical care, including intravenous thrombolysis (IVT). However, data on their impact on routine clinical care remains scarce. Methods: Using a prospective observational registry, we assessed: (1) the clinical and radiological characteristics of all consecutive patients treated with thrombectomy; (2) the outcome of all patients with M1 occlusion (treated with thrombectomy or IVT alone). Two periods were compared: before (2013-2014) and after (2015-2016) the publication of RT...
2018: Frontiers in Neurology
Jorge A Vargas, Valeri Petkov, El Said A Nouh, Raj Kumar Ramamoorthy, Lise-Marie Lacroix, Romuald Poteau, Guillaume Viau, Pierre Lecante, Raul Arenal
Despite the intensive interest in thin gold nanowires for a variety of technologically important applications, key details of the mechanism of their formation and atomic-scale structure remain unknown. Here we synthesize highly uniform, very long, and ultrathin gold nanowires in a liquid-phase environment and study their nucleation and growth using in situ high-energy synchrotron X-ray diffraction. By controlling the type of solvents, reducing agents, and gold precursor concentration, it is shown that the nucleation and growth of gold nanowires involve the emergence and self-assembly of transient linear gold complexes, respectively...
September 14, 2018: ACS Nano
Signe E Cremer, Jørgen Koch, Nanna Graversen, Anne S Gravgaard, Rebecca Langhorn, Annemarie T Kristensen, Jakob L Willesen, Lise N Nielsen
BACKGROUND: Cardiogenic embolism (CE) in cats is a devastating condition primarily associated with hypertrophic cardiomyopathy (HCM). Hypercoagulability may pose a risk for thrombus formation; however, no single test can predict CE development. Platelet microparticles (PMPs) released from platelet membranes are associated with thrombosis in humans. OBJECTIVES: The aims were to validate flow cytometric PMP quantification in cats analytically and, in a pilot study, evaluate the procoagulant annexin V (AnV) positive PMP concentration in healthy cats and cats with asymptomatic HCM...
September 2018: Veterinary Clinical Pathology
Martin Kurnik, Cagla Sahin, Camilla Bertel Andersen, Nikolai Lorenzen, Lise Giehm, Hossein Mohammad-Beigi, Christian Moestrup Jessen, Jan Skov Pedersen, Gunna Christiansen, Steen Vang Petersen, Roland Staal, Girija Krishnamurthy, Keith Pitts, Peter H Reinhart, Frans A A Mulder, Scot Mente, Warren D Hirst, Daniel E Otzen
α-Synuclein (αSN) aggregation is central to the etiology of Parkinson's disease (PD). Large-scale screening of compounds to identify aggregation inhibitors is challenged by stochastic αSN aggregation and difficulties in detecting early-stage oligomers (αSOs). We developed a high-throughput screening assay combining SDS-stimulated αSN aggregation with FRET to reproducibly detect initial stages in αSN aggregation. We screened 746,000 compounds, leading to 58 hits that markedly inhibit αSN aggregation and reduce αSOs' membrane permeabilization activity...
August 29, 2018: Cell Chemical Biology
T Michael Yates, Mohnish Suri, Archana Desurkar, Gaetan Lesca, Carina Wallgren-Pettersson, Trine B Hammer, Ashok Raghavan, Anne-Lise Poulat, Rikke S Møller, Ann-Charlotte Thuresson, Meena Balasubramanian
We aim to further delineate the phenotype associated with pathogenic variants in the SLC35A2 gene, and review all published literature to-date. This gene is located on the X chromosome and encodes a UDP-galactose transporter. Pathogenic variants in SLC35A2 cause a congenital disorder of glycosylation. The condition is rare, and less than twenty patients have been reported to-date. The phenotype is complex and has not been fully defined. Here, we present a series of five patients with de novo pathogenic variants in SLC35A2...
August 27, 2018: European Journal of Paediatric Neurology: EJPN
Chen Chen, Fei Li, Weixia Wei, Zirong Wang, Juanjuan Dai, Lilan Hao, Liju Song, Xiaowei Zhang, Liping Zeng, Hui Du, Huiru Tang, Na Liu, Huanming Yang, Jian Wang, Lise Madsen, Susanne Brix, Karsten Kristiansen, Xun Xu, Junhua Li, Ruifang Wu, Huijue Jia
Background: The human uterus is traditionally believed to be sterile, while the vaginal microbiota plays important role in fending off pathogens. Emerging evidence demonstrates the presence of bacteria beyond the vagina. However, a microbiome-wide metagenomic analysis identifying the overall microorganism communities has been lacking. Results: We performed shotgun-sequencing using the Illumina platform of 52 samples from the cervical canal and peritoneal fluid of Chinese women in reproductive age...
September 6, 2018: GigaScience
Siddhartha De, Lise-Marie Chamoreau, Hasnaa El Said, Yanling Li, Alexandrine Flambard, Marie-Laure Boillot, Subrata Tewary, Gopalan Rajaraman, Rodrigue Lescouëzec
Two new iron(II) neutral complexes of bis(1-methylimidazol-2-yl)ketone (Me bik) with molecular formula [FeII (Me bik)2 (NCS)2 ] ( 1 ) and [FeII (Me bik)2 (NCSe)2 ] ( 2 ) have been synthesized and characterized by magnetic measurements, single-crystal X-ray diffraction, and solid state UV-vis spectroscopy. The temperature dependent magnetic susceptibility measurements of crystalline samples of both compound show the occurrence of a gradual spin transition centered at T 1 /2 = 260 K and 326 K, respectively. The crystal structures of both compounds were determined at different temperatures, below and above the transition, in order to detect the structural changes associated with the spin transition...
2018: Frontiers in Chemistry
Stéphanie Salesse, Ludivine Odoul, Lise Chazée, Christian Garbar, Laurent Duca, Laurent Martiny, Rachid Mahmoudi, Laurent Debelle
Elastin is a long-lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of elastin fragments. In invasive human breast cancers, an increase in elastosis is correlated with severity of the disease and age of the patient. Elastin-derived peptides (EDPs) are a hallmark of aging and are matrikines - matrix fragments having the ability to regulate cell physiology...
September 2018: FEBS Open Bio
Jennifer Lising Roxas, Gayatri Vedantam, V K Viswanathan
Desmosomes are junctional protein complexes that confer strong adhesive capacity to adjacent host cells. In a recent study, we showed that enteropathogenic Escherichia coli (EPEC) disrupts desmosomes, weakens cell-cell adhesion and perturbs barrier function of intestinal epithelial (C2BBe ) cells. Desmosomal damage was dependent on the EPEC effector protein EspH and its inhibitory effect on Rho GTPases. EspH-mediated Rho inactivation resulted in retraction of keratin intermediate filaments and degradation of desmosomal cadherins...
September 5, 2018: Gut Microbes
Iben Daugaard, Dianna Hussmann, Louise Kristensen, Thomas Kristensen, Tina E Kjeldsen, Charlotte G Nyvold, Thomas S Larsen, Michael B Møller, Lise Lotte Hansen, Tomasz K Wojdacz
AIM: We investigated whether DNA methylation regulates expression of LPL and PI3K complex genes in chronic lymphocytic leukemia (CLL) and evaluated the prognostic significance of LPL promoter methylation in CLL patients. Patients & methods: Methylation of LPL promoter was assessed in 112 patients using methylation-sensitive high-resolution melting (MS-HRM). RESULTS: Patients with a fully or heterogeneously methylated LPL promoter had significantly longer median time to treatment (p < 0...
September 5, 2018: Epigenomics
Lise Charuaud, Emilie Jarde, Anne Jaffrezic, Marie-Florence Thomas, Barbara Le Bot
Veterinary pharmaceuticals (VPs) increasingly used in animal husbandry have led to their presence in aquatic environments -surface water (SW) or groundwater (GW) - and even in tap water. This review focuses on studies from 2007 to 2017. Sixty-eight different veterinary pharmaceutical residues (VPRs) have been quantified worldwide in natural waters at concentrations ranging from nanograms per liter (ng L-1 ) to several micrograms per liter (μg L-1 ). An extensive up-to-date on sales and tonnages of VPs worldwide has been performed...
August 24, 2018: Journal of Hazardous Materials
Anne-Laure Hérissé, Anne-Lise Luci, Federico Solla, Myriam Guesmi, Diane Demonchy, Virginie Rampal, Hervé Haas, Antoine Tran
No abstract text is available yet for this article.
September 3, 2018: Archives of Disease in Childhood
Mavish S Chaudry, Gunnar H Gislason, Anne-Lise Kamper, Marianne Rix, Anders Dahl, Lauge Østergaard, Emil L Fosbøl, Trine K Lauridsen, Louise B Oestergaard, Christian Hassager, Christian Torp-Pedersen, Niels E Bruun
BACKGROUND: The risk of infective endocarditis (IE) is markedly increased in patients receiving chronic hemodialysis compared with the general population, but outcome data are sparse. The present study investigated causes and risk factors of mortality in a hemodialysis-treated end-stage kidney disease- (ESKD) and a non-ESKD population with staphylococcus (S.) aureus endocarditis. METHODS: Hemodialysis-treated ESKD patients with S. aureus endocarditis were identified from Danish National Registries and Non-ESKD patients from The East Danish Database on Endocarditis...
September 3, 2018: BMC Nephrology
Elizabeth Andersen, Lise Olsen, Jacqueline Denison, Ismat Zerin, Manuela Reekie
BACKGROUND/OBJECTIVES: The ability to be a reflective practitioner is recognized by nursing regulatory bodies as a component of professional competence and becoming a reflective practitioner is an essential part of learning to become a nurse. In this multi-site study, we explored undergraduate nursing students' beliefs, capacities and intentions to participate in reflective, debriefing discussions facilitated by clinical instructors. At the same time, we tested the effectiveness of a period of rest and an intervention designed to refresh and inspire them...
November 2018: Nurse Education Today
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