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https://www.readbyqxmd.com/read/28240735/universal-expositions-physics-chemistry-and-new-occupational-diseases-the-case-of-marie-sklodowska-curie-and-radium-girls
#1
Silvana Salerno
BACKGROUND: Radium discovery by Marie and Pierre Curies caused previously unknown diseases. Marie Sklodowska Curie (1867-1934) suffered from radiations effects, as did girls in the radium dial watches factories. Therapeutic effects of radium were soon discovered, its unhealthy effects were as yet unheard of. OBJECTIVES: Analysis of Marie Sklodowska Curie (Marie) and radium girls occupational exposure, taking scientific debate on radium dangerous effects into account...
February 15, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28239666/making-the-most-of-rna-seq-pre-processing-sequencing-data-with-opossum-for-reliable-snp-variant-detection
#2
Laura Oikkonen, Stefano Lise
Identifying variants from RNA-seq (transcriptome sequencing) data is a cost-effective and versatile alternative to whole-genome sequencing. However, current variant callers do not generally behave well with RNA-seq data due to reads encompassing intronic regions. We have developed a software programme called Opossum to address this problem. Opossum pre-processes RNA-seq reads prior to variant calling, and although it has been designed to work specifically with Platypus, it can be used equally well with other variant callers such as GATK HaplotypeCaller...
January 17, 2017: Wellcome Open Res
https://www.readbyqxmd.com/read/28238556/bile-acid-sequestrants-for-glycemic-control-in-patients-with-type-2-diabetes-a-systematic-review-with-meta-analysis-of-randomized-controlled-trials
#3
Morten Hansen, David P Sonne, Kristian H Mikkelsen, Lise Lotte Gluud, Tina Vilsbøll, Filip K Knop
AIM: To evaluate the effects of bile acid sequestrants (BASs) versus placebo, no intervention or active comparators on glycemic control in type 2 diabetes. METHODS: Data were retrieved and a systematic review with meta-analyses was performed. We evaluated bias control and subgroup and sensitivity analyses were performed to evaluate heterogeneity and bias. RESULTS: We included 17 trials with a total of 2950 patients randomized to BASs (colesevelam or colestimide) versus placebo, no intervention, statins or sitagliptin...
January 24, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28238035/major-antimicrobial-representatives-from-marine-sponges-and-or-their-associated-bacteria
#4
Fei He, Linh H Mai, Johan Gardères, Amjad Hussain, Vesna Erakovic Haber, Marie-Lise Bourguet-Kondracki
The rapid emergence of resistant bacteria during the last 20 years has stimulated research efforts in order to overcome this thorny problem. Marine sponges and their associated bacteria, which have been proven to be a source of bioactive natural products, have appeared as a promising opportunity to identify new antibiotic compounds. An overview of the major antibacterial compounds isolated from marine sponges and/or their associated bacteria is presented in this chapter, highlighting new potential antibiotics...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28237962/realist-evaluation-of-intersectoral-oral-health-promotion-interventions-for-schoolchildren-living-in-rural-andean-communities-a-research-protocol
#5
Dave A Bergeron, Lise R Talbot, Isabelle Gaboury
BACKGROUND: Intersectoral collaboration, known to promote more sustainable change within communities, will be examined in an oral health promotion program (OHPP). In Peru, an OHPP was implemented by the Ministry of Health, to reduce the incidence of caries in schoolchildren. In rural Andean communities, however, these initiatives achieved limited success. The objectives of this project are: (1) to understand the context and the underlying mechanisms associated with Peruvian OHPP's current effects among school children living in rural Andean communities and (2) to validate a theory explaining how and under which circumstances OHP intersectoral interventions on schoolchildren living in rural Andean communities produce their effects...
February 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28230372/formal-asymmetric-%C3%AE-alkenylation-of-aldehydes-and-the-synthetic-application-toward-forming-%C3%AE-exo-methylene-%C3%AE-butyrolactones-and-skipped-dienes
#6
Yang Li, Lise Ibsen, Karl Anker Jørgensen
A formal asymmetric α-alkenylation of aldehydes is reported based on the organocatalytic reaction of aldehydes with nitroacrylates. The reaction proceeds in a one-pot manner forming the products with up to 77% yield and up to >99% ee. This strategy is also successfully applied for the synthesis of α-exo-methylene-γ-butyrolactones and skipped diene scaffolds in a highly enantioselective manner.
February 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28225239/are-environmental-pollutants-in-the-norwegian-diet-harmful-to-children
#7
Bjørn J Bolann, Sandra Huber, Jerome Ruzzin, Jan Brox, Henrik S Huitfeldt, Anne-Lise Bjørke Monsen
No abstract text is available yet for this article.
February 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28224137/hmgb1-anti-hmgb1-antibodies-define-a-molecular-signature-of-early-stages-of-hiv-associated-neurocognitive-isorders-hand
#8
Marie-Lise Gougeon, Béatrice Poirier-Beaudouin, Jacques Durant, Christine Lebrun-Frenay, Héla Saïdi, Valérie Seffer, Michel Ticchioni, Stephane Chanalet, Helene Carsenti, Alexandra Harvey-Langton, Muriel Laffon, Jacqueline Cottalorda, Christian Pradier, Pierre Dellamonica, Matteo Vassallo
BACKGROUND: HIV-associated neurocognitive disorders (HAND) persist in the post-HAART era, characterized by asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorders (MND). High mobility group box 1 (HMGB1) is a non-histone chromosomal protein widely expressed in the nucleus of all eukaryotic cells, including brain cells, which acts as a potent proinflammatory cytokine when actively secreted from immune cells. Recent reports suggested that HMGB1 acts on microglial cells to promote neuroinflammation...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28221975/fate-of-listeria-monocytogenes-pathogenic-yersinia-enterocolitica-and-escherichia-coli-o157-h7-gfp-in-ready-to-eat-salad-during-cold-storage-what-is-the-risk-to-consumers
#9
Karin Söderqvist, Susanne Thisted Lambertz, Ivar Vågsholm, Lise-Lotte Fernström, Beatrix Alsanius, Lars Mogren, Sofia Boqvist
In this study, we investigated the fate of Listeria monocytogenes , pathogenic Yersinia enterocolitica , and Escherichia coli O157:H7 gfp(+) inoculated in low numbers into ready-to-eat baby spinach and mixed-ingredient salad (baby spinach with chicken meat). Samples were stored at recommended maximum refrigerator temperature (8°C in Sweden) or at an abuse temperature (15°C) for up to 7 days. Mixed-ingredient salad supported considerable growth when stored at 15°C during shelf life (3 days), with populations of L...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221925/genetic-diversity-and-antibiotic-resistance-of-escherichia-coli-isolates-from-different-leafy-green-production-systems
#10
Mosimanegape Jongman, Lise Korsten
Foodborne disease outbreaks linked to contaminated irrigation water and fresh produce are a public health concern. The presence of Escherichia coli isolates from irrigation water and leafy green vegetables in different food production systems (large commercial farms, small-scale farms, and homestead gardens) was investigated. The prevalence of antibiotic resistance and virulence in these isolates was further assessed, and links between water source and irrigated crops were identified using antimicrobial and genotypic analyses...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221909/effect-of-temperature-and-nutrient-concentration-on-survival-of-foodborne-pathogens-in-deciduous-fruit-processing-environments-for-effective-hygiene-management
#11
Stacey Duvenage, Lise Korsten
Temperature and good sanitation practices are important factors for controlling growth of microorganisms. Fresh produce is stored at various temperatures to ensure quality and to prolong shelf life. When foodborne pathogens survive and grow on fresh produce at storage temperatures, then additional control strategies are needed to inactivate these pathogens. The aim of this study was to determine how temperatures associated with deciduous fruit processing and storage facilities (0.5, 4, and 21°C) affect the growth and/or survival of Escherichia coli O157:H7, Listeria monocytogenes , Salmonella enterica subsp...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221902/monitoring-pesticide-residues-in-fruits-and-vegetables-at-two-of-the-biggest-fresh-produce-markets-in-africa
#12
Mbulaheni T Mutengwe, Lizyben Chidamba, Lise Korsten
In most countries, fresh produce sold at local markets is usually not analyzed for agricultural chemical residues as export products are, which raises concerns about the perceived safety levels of local food supplies in contrast with exported products. The aim of this study was to determine pesticide residue levels in fruits and vegetables sold at two of the biggest fresh produce markets in Africa. A total of 199 fruit and vegetable samples were collected between 2012 and 2014 and analyzed for 74 pesticides commonly used in the horticultural sector...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28220987/brain-tissue-reaction-to-deep-brain-stimulation-a-longitudinal-study-of-dbs-in-the-goettingen-minipig
#13
Dariusz Orlowski, Alexandre Michalis, Andreas N Glud, Anders R Korshøj, Lise M Fitting, Trine W Mikkelsen, André Mercanzini, Alain Jordan, Alain Dransart, Jens C H Sørensen
OBJECTIVES: The use of Deep Brain Stimulation (DBS) in treatment of various brain disorders is constantly growing; however, the number of studies of the reaction of the brain tissue toward implanted leads is still limited. Therefore, the aim of our study was to analyze the impact of DBS leads on brain tissue in a large animal model using minipigs. METHODS: Twelve female animals, one control and eleven with bilaterally implanted DBS electrodes were used in our experiment...
February 21, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28218316/theoretical-study-of-hcn-water-interaction-five-dimensional-potential-energy-surfaces
#14
Ernesto Quintas Sánchez, Marie-Lise Dubernet
A new five-dimensional potential energy surface is calculated at the coupled-cluster CCSD(T) level of theory for the HCN-water system, treating both monomers as rigid rotors. The associated methodology, which combines extensive ab initio calculations of moderate accuracy (CCSD(T)/AVDZ) and a fitting procedure involving a much lower angular coverage with more accurate ab initio calculations (CCSD(T)/CBS), is described in detail. This methodology provides a time-saving approach to compute quantitatively accurate potential energy surfaces with reasonable computational effort...
February 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28217969/postponing-a-general-practitioner-visit-describing-social-differences-in-thirty-one-european-countries
#15
Jens Detollenaere, Amelie Van Pottelberge, Lise Hanssens, Lieven Pauwels, Tessa van Loenen, Sara Willems
OBJECTIVE: To describe social differences in postponing a general practitioner visit in 31 European countries and to explore whether primary care strength is associated with postponement rates. DATA SOURCES: Between October 2011 and December 2013, the multicountry QUALICOPC study collected data on 61,931 patients and 7,183 general practitioners throughout Europe. STUDY DESIGN: Access to primary care was measured by asking the patients whether they postponed a general practitioner visit in the past year...
February 19, 2017: Health Services Research
https://www.readbyqxmd.com/read/28217275/multicentre-evaluation-of-the-na%C3%A3-da-ci-q70-sound-processor-feedback-from-cochlear-implant-users-and-professionals
#16
Jeanette Martin, Christine Poncet-Wallet, Angelika Illg, Sarah Perrin-Webb, Lise Henderson, Nathalie Noël-Petroff, Gennaro Auletta, Maria Grazia Barezzani, Karim Houri, Indian Research Group, Heike Bagus, Ulrich Hoppe, Jane Humphries, Wiebke van Treeck, Jeroen J Briaire, Martina Brendel, Nathalie Mathias
The aim of this survey was to gather data from both implant recipients and professionals on the ease of use of the Naída CI Q70 (Naída CI) sound processor from Advanced Bionics and on the usefulness of the new functions and features available. A secondary objective was to investigate fitting practices with the new processor. A comprehensive user satisfaction survey was conducted in a total of 186 subjects from 24 centres. In parallel, 23 professional questionnaires were collected from 11 centres. Overall, there was high satisfaction with the Naída CI processor from adults, children, experienced and new CI users as well as from professionals...
August 23, 2016: Audiology Research
https://www.readbyqxmd.com/read/28216127/speaking-related-changes-in-cortical-functional-connectivity-associated-with-assisted-and-spontaneous-recovery-from-developmental-stuttering
#17
Christian A Kell, Katrin Neumann, Marion Behrens, Alexander W von Gudenberg, Anne-Lise Giraud
We previously reported speaking-related activity changes associated with assisted recovery induced by a fluency shaping therapy program and unassisted recovery from developmental stuttering (Kell et al., Brain 2009). While assisted recovery re-lateralized activity to the left hemisphere, unassisted recovery was specifically associated with the activation of the left BA 47/12 in the lateral orbitofrontal cortex. These findings suggested plastic changes in speaking-related functional connectivity between left hemispheric speech network nodes...
February 13, 2017: Journal of Fluency Disorders
https://www.readbyqxmd.com/read/28215110/patients-family-members-and-professional-carers-experiences-of-psychoeducational-multifamily-groups-for-participants-with-intellectual-disabilities-and-mental-illness
#18
Trine Lise Bakken, Inger-Lise Sundby, Gunn Helene Klevmoen
There is a dearth of articles addressing psychoeducational multifamily groups for adults with intellectual disabilities. The objective of this study is to investigate the participants' experiences of being part of a group like this. The group intervention had been slightly modified due to the participants' intellectual disabilities. Four patients, their close relatives, and community professional caregivers were interviewed using a semi-structured scheme. The four patients had participated in different groups...
February 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28214537/biomechanical-behavior-of-endodontically-treated-premolars-using-different-preparation-designs-and-cad-cam-materials
#19
Diogo Pedrollo Lise, Annelies Van Ende, Jan De Munck, Thaís Yumi Umeda Suzuki, Luiz Clovis Cardoso Vieira, Bart Van Meerbeek
OBJECTIVES: To evaluate the effect of restoration design ('2.5-mm deep endocrown', '5-mm deep endocrown' or '5-mm deep post&crown') and CAD/CAM material type (composite or lithium disilicate glass-ceramic) on the load-to-failure of endodontically treated premolars in absence of any ferrule. METHODS: The crowns of 48 single-rooted premolars were cut and the roots were endodontically treated. Teeth were randomly divided into six groups (n=8); teeth in each group were restored using one of the two tested materials with standardized CAD/CAM fabricated endocrowns (with either 2...
February 15, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28213863/hyperkalemia-is-associated-with-increased-30-day-mortality-in-hip-fracture-patients
#20
Debbie Norring-Agerskov, Christian Medom Madsen, Bo Abrahamsen, Troels Riis, Ole B Pedersen, Niklas Rye Jørgensen, Lise Bathum, Jes Bruun Lauritzen, Henrik L Jørgensen
Abnormal plasma concentrations of potassium in the form of hyper- and hypokalemia are frequent among hospitalized patients and have been linked to poor outcomes. In this study, we examined the prevalence of hypo- and hyperkalemia in patients admitted with a fractured hip as well as the association with 30-day mortality in these patients. A total of 7293 hip fracture patients (aged 60 years or above) with admission plasma potassium measurements were included. Data on comorbidity, medication, and death was retrieved from national registries...
February 17, 2017: Calcified Tissue International
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