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Paul L Aronson, Marie E Wang, Eugene D Shapiro, Samir S Shah, Adrienne G DePorre, Russell J McCulloh, Christopher M Pruitt, Sanyukta Desai, Lise E Nigrovic, Richard D Marble, Rianna C Leazer, Sahar N Rooholamini, Laura F Sartori, Fran Balamuth, Christopher Woll, Mark I Neuman
: media-1vid110.1542/5840460609001PEDS-VA_2018-1879 Video Abstract OBJECTIVES: To evaluate the Rochester and modified Philadelphia criteria for the risk stratification of febrile infants with invasive bacterial infection (IBI) who do not appear ill without routine cerebrospinal fluid (CSF) testing. METHODS: We performed a case-control study of febrile infants ≤60 days old presenting to 1 of 9 emergency departments from 2011 to 2016. For each infant with IBI (defined as a blood [bacteremia] and/or CSF [bacterial meningitis] culture with growth of a pathogen), controls without IBI were matched by site and date of visit...
November 13, 2018: Pediatrics
Inger Lise Gade, Signe Juul Riddersholm, Ilse Christiansen, Annika Rewes, Mikael Frederiksen, Lisbeth Enggaard, Christian Bjørn Poulsen, Olav Jonas Bergmann, Dorte Balle Gillström, Robert Schou Pedersen, Linda Nielsen, Helle Højmark Eriksen, Christian Torp-Pedersen, Søren Risom Kristensen, Marianne Tang Severinsen
Venous thromboembolism (VTE) is associated with inferior survival in cancer patients. The risk of VTE and its effect on survival in chronic lymphocytic leukemia (CLL) patients remains unclear. The present study investigated the impact of patient-related factors, CLL prognostic markers, and CLL treatment on the risk of VTE and assessed overall survival relative to VTE. All patients in the Danish National CLL Registry (2008-2015) were followed from the date of CLL diagnosis to death, VTE, emigration, or administrative censoring...
November 13, 2018: Blood Advances
Lise Schotte, Magali Wautier, Delphine Martiny, Denis Piérard, Melissa Depypere
Haemophilus influenzae, a frequent colonizer of the respiratory tract, is the causative agent of several clinically important infections. In cases that require therapeutic intervention, laboratory susceptibility testing can detect beta-lactam antibiotic resistance and guide the best treatment course. In the absence of a beta-lactamase, beta-lactam resistance may be due to an altered form of the PBP3 protein, encoded by the ftsI gene. While these so-called beta-lactamase-negative ampicillin-resistant (BLNAR) strains are of serious clinical interest, identification in the clinical laboratory is not always straightforward...
October 17, 2018: Diagnostic Microbiology and Infectious Disease
Fran Balamuth, Andrea T Cruz, Stephen B Freedman, Paul T Ishimine, Aris Garro, Sarah Curtis, Kendra L Grether-Jones, Aaron S Miller, Neil G Uspal, Suzanne M Schmidt, Samir S Shah, Lise E Nigrovic
In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.
November 12, 2018: Pediatric Emergency Care
Marianne H Abel, Ragnhild E Brandlistuen, Ida H Caspersen, Heidi Aase, Liv E Torheim, Helle Margrete Meltzer, Anne Lise Brantsaeter
PURPOSE: Some studies indicate that mild-to-moderate iodine deficiency in pregnant women might negatively affect offspring neurocognitive development, including previous results from the Norwegian Mother and Child Cohort study (MoBa) exploring maternally reported child development at age 3 years. The aim of this follow-up study was to investigate whether maternal iodine intake in pregnancy is associated with language and learning at 8 years of age. METHODS: The study sample includes 39,471 mother-child pairs participating in MoBa with available information from a validated food frequency questionnaire covering the first half of pregnancy and a questionnaire on child neurocognitive development at 8 years...
November 12, 2018: European Journal of Nutrition
Mia E Persson, Ann-Sofie Sundman, Lise-Lotte Halldén, Agaia J Trottier, Per Jensen
Background: Dogs have human-directed social skills that allow them to communicate and cooperate with humans. We have previously identified two loci on chromosome 26 associated with human contact-seeking behaviors during an unsolvable problem task in laboratory beagles (Persson et al., 2016). The aim of the present study was to verify the single nucleotide polymorphisms (SNPs) in additional dog breeds. We also studied how the allele frequencies have changed during domestication and recent selection...
2018: PeerJ
Vigdis Abrahamsen Grøndahl, Jörg W Kirchhoff, Kirsti Lauvli Andersen, Lise Aagaard Sørby, Hilde Marie Andreassen, Eli-Anne Skaug, Anne Karine Roos, Liv Solveig Tvete, Ann Karin Helgesen
Purpose: Previous studies show that the hospital environment and the behavior of health care personnel may predict patients' perceptions of care quality. The aim of the study was to explore changes in perceived care quality from the patients' perspective (QPP) when hospital services are relocated from an old to a new high-tech hospital and to describe what is important for patients in the high-tech hospital. Patients and methods: A comparative cross-sectional design was used...
2018: Journal of Multidisciplinary Healthcare
Raoul Walther, Anna Winther, Anne Sofie Fruergaard, Wouter van den Akker, Lise Sørensen, Signe Maria Nielsen, Morten Jarlstad Olesen, Yitao Dai, Henrik Jeppesen, Paolo Lamagni, Aleksandr Savateev, Søren Pedersen, Camilla Frich, Cecile Vigier-Carrière, Nina Lock, Mandeep Singh, Vipul Bansal, Rikke Meyer, Alexander N Zelikin
Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of Origin of Life. However, current nanozymes offer mimicry to a narrow range of mammalian enzymes, near-exclusively performing redox reactions. In this work, we present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. Specific novelty of our findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases...
November 8, 2018: Angewandte Chemie
Lise J Harbom, Taylor L Rudisill, Nadine Michel, Karen A Litwa, Mark P Beenhakker, Michael J McConnell
Induced pluripotent stem cell (iPSC)-derived neurons permit the study of neurogenesis and neurological disease in a human setting. However, the electrophysiological properties of iPSC-derived neurons are consistent with those observed in immature cortical neurons, including a high membrane resistance depolarized resting membrane potential and immature firing properties, limiting their use in modeling neuronal activity in adult cells. Based on the proven association between inhibiting rho kinase (ROCK) and increased neurite complexity, we seek to determine if short-term ROCK inhibition during the first 1-2 weeks of differentiation would increase morphological complexity and electrophysiological maturity after several weeks of differentiation...
November 8, 2018: Cell and Tissue Research
Willem B Verwey, Anne-Lise Jouen, Peter F Dominey, Jocelyne Ventre-Dominey
To explore the effects of practice we scanned participants with fMRI while they were performing four-key unfamiliar and familiar sequences, and compared the associated activities relative to simple control sequences. On the basis of a recent cognitive model of sequential motor behavior (C-SMB), we propose that the observed neural activity would be associated with three functional networks that can operate in parallel and that allow (a) responding to stimuli in a reaction mode, (b) sequence execution using spatial sequence representations in a central-symbolic mode, and (c) sequence execution using motor chunk representations in a chunking mode...
November 7, 2018: Cognitive, Affective & Behavioral Neuroscience
Florent Mouliere, Dineika Chandrananda, Anna M Piskorz, Elizabeth K Moore, James Morris, Lise Barlebo Ahlborn, Richard Mair, Teodora Goranova, Francesco Marass, Katrin Heider, Jonathan C M Wan, Anna Supernat, Irena Hudecova, Ioannis Gounaris, Susana Ros, Mercedes Jimenez-Linan, Javier Garcia-Corbacho, Keval Patel, Olga Østrup, Suzanne Murphy, Matthew D Eldridge, Davina Gale, Grant D Stewart, Johanna Burge, Wendy N Cooper, Michiel S van der Heijden, Charles E Massie, Colin Watts, Pippa Corrie, Simon Pacey, Kevin M Brindle, Richard D Baird, Morten Mau-Sørensen, Christine A Parkinson, Christopher G Smith, James D Brenton, Nitzan Rosenfeld
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alterations but have rarely considered the biological properties of plasma cell-free DNA (cfDNA). We hypothesized that differences in fragment lengths of circulating DNA could be exploited to enhance sensitivity for detecting the presence of ctDNA and for noninvasive genomic analysis of cancer. We surveyed ctDNA fragment sizes in 344 plasma samples from 200 patients with cancer using low-pass whole-genome sequencing (0...
November 7, 2018: Science Translational Medicine
Stine Jacobsen, Lise C Berg, Emil Tvermose, Malene B Laurberg, Gaby van Galen
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be a useful marker of kidney injury in people and dogs, but has not been described in horses. OBJECTIVES: The aim of the study was to validate a commercially available porcine-specific ELISA to measure serum concentrations of equine NGAL. METHODS: Intra- and interassay imprecisions were evaluated by multiple measurements on equine serum pools. Assay inaccuracy was determined by the linearity under dilution...
November 7, 2018: Veterinary Clinical Pathology
Thi Thanh Van Trinh, Bich Ngan Truong, Arlette Longeon, Thi Mai Huong Doan, Alexandre Deville, Van Minh Chau, Van Cuong Pham, Marie-Lise Bourguet-Kondracki
Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22( E )-dien-3β,9α-diol ( 1 ), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol ( 2 ), (24 R )-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol ( 3 ), 5α,6α-epoxycholesta-7-en-3β,9α-diol ( 4 ), (24 S )-5α,6α-epoxyergosta-7,22-dien-3β,9α-diol ( 5 ), and (24 R )-5α,6α-epoxy-24-methyl-cholesta-7-en-3β,9α-diol ( 6 ) along with the known 5α-6α-epoxysterols: 5α,6α-epoxystigmasta-7-en-3β-ol ( 7 ), 5α,6α-epoxystigmasta-7,22-dien-3β-ol ( 8 ), and 5α,6α-epoxyergosta-7-en-3β-ol ( 9 )...
November 1, 2018: Marine Drugs
Birgit Alsbjerg, Lise Thomsen, Helle O Elbaek, Rita Laursen, Betina B Povlsen, Thor Haahr, Peter Humaidan
RESEARCH QUESTION: Do serum progesterone levels determine ongoing pregnancy rates (OPR) in hormone replacement therapy frozen-thawed embryo transfer (HRT-FET) cycles? DESIGN: A cohort study of 244 HRT-FET cycles from a Danish public fertility centre. Data from patients undergoing HRT-FET from January 2016 to December 2017 were extracted from a clinical database. All patients had transfer in HRT cycles of autologous embryos frozen on day 5 or 6. Endometrial preparation was performed using 6 mg oestradiol valerate daily from the second day of the cycle followed by vaginal micronized progesterone (90 mg/8 h)...
October 6, 2018: Reproductive Biomedicine Online
Mariangela De Robertis, Lise Pasquet, Luisa Loiacono, Elisabeth Bellard, Luciano Messina, Susanna Vaccaro, Roberta Di Pasquale, Vito Michele Fazio, Marie-Pierre Rols, Justin Teissie, Muriel Golzio, Emanuela Signori
Cancer vaccines based on plasmid DNA represent a good therapeutic perspective, despite their low potency. Animal-derived hyaluronidases (Hyals) are employed in oncological clinical practice. Hyal has been also demonstrated to be a good enhancer of intramuscular Gene Electro-Transfer (GET) efficiency in anti-cancer preclinical protocols, with increased transfected cells and higher expression of the encoded genes. Nevertheless, the use of animal-derived Hyals results limited respect to their potentialities, since such preparations could be affected by low purity, variable potency and uncertain safety...
October 28, 2018: Cancers
Antony P Zacharias, Rebecca Jeyaraj, Lise Hobolth, Flemming Bendtsen, Lise Lotte Gluud, Marsha Y Morgan
BACKGROUND: Non-selective beta-blockers are recommended for the prevention of bleeding in people with cirrhosis, portal hypertension and gastroesophageal varices. Carvedilol is a non-selective beta-blocker with additional intrinsic alpha1 -blocking effects, which may be superior to traditional, non-selective beta-blockers in reducing portal pressure and, therefore, in reducing the risk of upper gastrointestinal bleeding. OBJECTIVES: To assess the beneficial and harmful effects of carvedilol compared with traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices...
October 29, 2018: Cochrane Database of Systematic Reviews
Jiana Li, Amy L Lusher, Jeanette M Rotchell, Salud Deudero, Alexander Turra, Inger Lise N Bråte, Chengjun Sun, M Shahadat Hossain, Qipei Li, Prabhu Kolandhasamy, Huahong Shi
The ubiquity and high bioavailability of microplastics have an unknown risk on the marine environment. Biomonitoring should be used to investigate biotic impacts of microplastic exposure. While many studies have used mussels as indicators for marine microplastic pollution, a robust and clear justification for their selection as indicator species is still lacking. Here, we review published literature from field investigations and laboratory experiments on microplastics in mussels and critically discuss the suitability and challenges of mussels as bioindicator for microplastic pollution...
October 9, 2018: Environmental Pollution
Paul Berveiller, Olivier Mir, Séverine A Degrelle, Vassilis Tsatsaris, Lise Selleret, Jean Guibourdenche, Danièle Evain-Brion, Thierry Fournier, Sophie Gil
Introduction The use of paclitaxel in pregnant cancer patients is feasible in terms of fetal safety, but little is known about the effects of paclitaxel on the placenta. Using three experimental models, we aimed to assess the effects of paclitaxel on the expression of placental drug transporters. Methods In the in vitro model (human primary trophoblast culture), trophoblasts were isolated from normal term placentas and subsequently exposed to paclitaxel. The transcriptional regulation of 84 genes encoding for drug transporters, and the protein expression of ABCB1/P-gp and ABCG2/BCRP were assessed...
October 26, 2018: Investigational New Drugs
Anne Marte Sjursen Kvello, Jannike Morch Andersen, Elisabeth Leere Oiestad, Synne Steinsland, Audun Aase, Jorg Morland, Inger Lise Bogen
Escalating opioid use among fertile women has increased the number of children being exposed to opioids during fetal life. Furthermore, accumulating evidence links prenatal opioid exposure, including opioid maintenance treatment, to long-term negative effects on cognition and behavior, and presses the need to explore novel treatment strategies for pregnant opioid users. The present study examined the potential of a monoclonal antibody (mAb) targeting heroin's first metabolite, 6-acetylmorphine (6-AM), in providing fetal protection against harmful effects of prenatal heroin exposure in mice...
October 25, 2018: Journal of Pharmacology and Experimental Therapeutics
Ingrid Kvestad, Silje Vabø, Marian Kjellevold, Ole Jakob Nøstbakken, Lisa Kolden Midtbø, Mari Hysing, Maria Wik Markhus, Lise Madsen, Katina Handeland, Ingvild Eide Graff, Øyvind Lie, Livar Frøyland, Kjell Morten Stormark, Lisbeth Dahl, Jannike Øyen
BACKGROUND: The toxic effects of prenatal methylmercury (MeHg) include neurological abnormalities and developmental delay of which infants and children are particular susceptible. Studies on the effects of low and moderate exposure show conflicting results. Seafood is the main dietary source of MeHg, but also contributes with nutrients regarded as beneficial for development. OBJECTIVES: To measure the change in total hair mercury concentration (THHg) after an intervention of lunch meals with fatty fish or meat in Norwegian preschool children, and to examine the associations between THHg and cognitive function...
October 22, 2018: Environment International
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