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https://www.readbyqxmd.com/read/28436283/trigger-factors-in-childhood-migraine-a-prospective-clinic-based-study-from-north-of-france
#1
Lise Solotareff, Jean-Christophe Cuvellier, Alain Duhamel, Louis Vallée, Sylvie Nguyen The Tich
The objective was to study the prevalence and characterization of pediatric migraine triggers and to compare results to this retrospective study. A total of 101 pediatric patients with ICHD-II migraine with and/or without aura were instructed to prospectively complete a diary dealing with attacks triggers for a 3-month period. Each subject reported at least 1 trigger (range: 1-14) with a total number of 532 attacks and a median per subject of 3. Lack of sleep (51.4%), stress (44.6%), warm climate (41.9%), noise (32...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28435129/laparoscopic-sacral-colpopexy-the-%C3%A2-6points-%C3%A2-technique
#2
Marie Schaub Resident, Lise Lecointre, Emilie Faller, Thomas Boisramé, Jean-Jacques Baldauf, Arnaud Wattiez, Cherif Youssef Akladios
STUDY OBJECTIVE: Illustrate laparoscopic sacral colpopexy for pelvic organ prolapse, a new method using a simplified mesh fixation technique, with only six fixation points DESIGN: A step-by-step explanation of the surgery using video (educative video) The video was approved by the local IRB. SETTING: University Hospital of Strasbourg, France. PATIENTS: Women with multicompartment prolapse INTERVENTION: First, we dissect the promontorium, and vertically incise the posterior parietal peritoneum on the right pelvic sidewall until the pouch of Douglas...
April 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28434644/research-priorities-for-a-multi-center-child-abuse-network-lessons-learned-from-pediatric-emergency-medicine-networks
#3
Rachel M Stanley, Lise E Nigrovic
No abstract text is available yet for this article.
April 20, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28432040/usability-acceptability-and-adherence-to-an-electronic-self-monitoring-system-in-patients-with-major-depression-discharged-from-inpatient-wards
#4
Lise Lauritsen, Louise Andersen, Emilia Olsson, Stine Rauff Søndergaard, Lasse Benn Nørregaard, Philip Kaare Løventoft, Signe Dunker Svendsen, Erik Frøkjær, Hans Mørch Jensen, Ida Hageman, Lars Vedel Kessing, Klaus Martiny
BACKGROUND: Patients suffering from depression have a high risk of relapse and readmission in the weeks following discharge from inpatient wards. Electronic self-monitoring systems that offer patient-communication features are now available to offer daily support to patients, but the usability, acceptability, and adherence to these systems has only been sparsely investigated. OBJECTIVE: We aim to test the usability, acceptability, adherence, and clinical outcome of a newly developed computer-based electronic self-assessment system (the Daybuilder system) in patients suffering from depression, in the period from discharge until commencing outpatient treatment in the Intensive Outpatient Unit for Affective Disorders...
April 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28431157/agreement-between-renal-prescribing-references-and-determination-of-prescribing-appropriateness-in-hospitalised-patients-with-chronic-kidney-disease
#5
Michelle O'Shaughnessy, Niamh Allen, John O'Regan, Edwina Payne-Danson, Lise Mentre, Dawn Davin, Peter Lavin, Tamasine Grimes
Background: Chronic kidney disease (CKD) is a risk factor for adverse drug events. The clinical significance of discordance between renal prescribing references is unknown. Aim: We determined the prevalence of potentially inappropriate prescribing (PIP) in CKD, measured agreement between two prescribing references, and assessed potential for harm consequent to PIP. Design: Single-centre observational study. Methods: A random sample of hospitalised patients with CKD were grouped according to baseline CKD stage (3, 4, or 5)...
April 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28429234/neuron-to-neuron-transfer-of-fus-in-drosophila-primary-neuronal-culture-is-enhanced-by-als-associated-mutations
#6
Sébastien Feuillette, Morgane Delarue, Gaëtan Riou, Anne-Lise Gaffuri, Jane Wu, Zsolt Lenkei, Olivier Boyer, Thierry Frébourg, Dominique Campion, Magalie Lecourtois
The DNA- and RNA-binding protein fused in sarcoma (FUS) has been pathologically and genetically linked to amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). Cytoplasmic FUS-positive inclusions were identified in the brain and spinal cord of a subset of patients suffering with ALS/FTLD. An increasing number of reports suggest that FUS protein can behave in a prion-like manner. However, no neuropathological studies or experimental data were available regarding cell-to-cell spread of these pathological protein assemblies...
April 20, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28427466/determinants-of-orphan-drugs-prices-in-france-a-regression-analysis
#7
Daria Korchagina, Aurelie Millier, Anne-Lise Vataire, Samuel Aballea, Bruno Falissard, Mondher Toumi
BACKGROUND: The introduction of the orphan drug legislation led to the increase in the number of available orphan drugs, but the access to them is often limited due to the high price. Social preferences regarding funding orphan drugs as well as the criteria taken into consideration while setting the price remain unclear. The study aimed at identifying the determinant of orphan drug prices in France using a regression analysis. METHODS: All drugs with a valid orphan designation at the moment of launch for which the price was available in France were included in the analysis...
April 21, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28427444/interventions-to-reduce-wait-times-for-primary-care-appointments-a-systematic-review
#8
Dominique Ansell, James A G Crispo, Benjamin Simard, Lise M Bjerre
BACKGROUND: Accessibility and availability are important characteristics of efficient and effective primary healthcare systems. Currently, timely access to a family physician is a concern in Canada. Adverse outcomes are associated with longer wait times for primary care appointments and often leave individuals to rely on urgent care. When wait times for appointments are too long patients may experience worse health outcomes and are often left to use emergency department resources. The primary objective of our study was to systematically review the literature to identify interventions designed to reduce wait times for primary care appointments...
April 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28424425/ephrin-b3-supports-glioblastoma-growth-by-inhibiting-apoptosis-induced-by-the-dependence-receptor-epha4
#9
Amélie Royet, Laura Broutier, Marie-May Coissieux, Céline Malleval, Nicolas Gadot, Denis Maillet, Lise Gratadou-Hupon, Agnès Bernet, Pascale Nony, Isabelle Treilleux, Jérôme Honnorat, Daniel Liebl, Laurent Pelletier, François Berger, David Meyronet, Marie Castets, Patrick Mehlen
EphA4, an Ephrins tyrosine kinase receptor, behaves as a dependence receptor (DR) by triggering cell apoptosis in the absence of its ligand Ephrin-B3. DRs act as conditional tumor suppressors, engaging cell death based on ligand availability; this mechanism is bypassed by overexpression of DRs ligands in some aggressive cancers. The pair EphA4/Ephrin-B3 favors survival of neuronal progenitors of the brain subventricular zone, an area where glioblastoma multiform (GBM) are thought to originate. Here, we report that Ephrin-B3 is highly expressed in human biopsies and that it inhibits EphA4 pro-apoptotic activity in tumor cells...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423606/ephrin-b3-supports-glioblastoma-growth-by-inhibiting-apoptosis-induced-by-the-dependence-receptor-epha4
#10
Amélie Royet, Laura Broutier, Marie-May Coissieux, Céline Malleval, Nicolas Gadot, Denis Maillet, Lise Gratadou-Hupon, Agnès Bernet, Pascale Nony, Isabelle Treilleux, Jérôme Honnorat, Daniel Liebl, Laurent Pelletier, François Berger, David Meyronet, Marie Castets, Patrick Mehlen
EphA4, an Ephrins tyrosine kinase receptor, behaves as a dependence receptor (DR) by triggering cell apoptosis in the absence of its ligand Ephrin-B3. DRs act as conditional tumor suppressors, engaging cell death based on ligand availability; this mechanism is bypassed by overexpression of DRs ligands in some aggressive cancers. The pair EphA4/Ephrin-B3 favors survival of neuronal progenitors of the brain subventricular zone, an area where glioblastoma multiform (GBM) are thought to originate. Here, we report that Ephrin-B3 is highly expressed in human biopsies and that it inhibits EphA4 pro-apoptotic activity in tumor cells...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423407/randomized-trial-comparing-a-web-mediated-follow-up-with-routine-surveillance-in-lung-cancer-patients
#11
Fabrice Denis, Claire Lethrosne, Nicolas Pourel, Olivier Molinier, Yoann Pointreau, Julien Domont, Hugues Bourgeois, Hélène Senellart, Pierre Trémolières, Thibaut Lizée, Jaafar Bennouna, Thierry Urban, Claude El Khouri, Alexandre Charron, Anne-Lise Septans, Magali Balavoine, Sébastien Landry, Philippe Solal-Céligny, Christophe Letellier
Background: The use of web-based monitoring for lung cancer patients is growing in interest because of promising recent results suggesting improvement in cancer and resource utilization outcomes. It remains an open question whether the overall survival (OS) in these patients could be improved by using a web-mediated follow-up rather than classical scheduled follow-up and imaging. Methods: Advanced-stage lung cancer patients without evidence of disease progression after or during initial treatment were randomly assigned in a multicenter phase III trial to compare a web-mediated follow-up algorithm (experimental arm), based on weekly self-scored patient symptoms, with routine follow-up with CT scans scheduled every three to six months according to the disease stage (control arm)...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28418992/initiation-of-antiretroviral-therapy-containing-integrase-inhibitors-increases-the-risk-of-iris-requiring-hospitalization
#12
Marine Dutertre, Lise Cuzin, Elisa Demonchy, Pascal Puglièse, Véronique Joly, Marc-Antoine Valantin, Laurent Cotte, Thomas Huleux, Pierre Delobel, Guillaume Martin-Blondel
No abstract text is available yet for this article.
April 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28417079/detection-of-copy-number-alterations-in-cell-free-tumor-dna-from-plasma
#13
Olga Østrup, Lise Barlebo Ahlborn, Ulrik Lassen, Morten Mau-Sørensen, Finn Cilius Nielsen
BACKGROUND: Somatic copy number alterations (SCNAs) occurring in tumors can provide information about tumor classification, patient's outcome or treatment targets. Liquid biopsies, incl. plasma samples containing circulating cell-free tumor DNA (ccfDNA) can be used to assess SCNAs for clinical purposes, however specify and reliability of methods have to be tested. METHODS: SNP microarrays (Affymetrix) were used to generate whole-genome copy number profiles from plasma ccfDNA (OncoScan) and paired tumor biopsies (CytoScan) from ten patients with metastatic cancers...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28416062/-growing-pains-are-well-known-but-the-cause-remains-unclear
#14
Fie Brantbjerg Tinning, Lise Hestbæk, Anne-Marie Nybo Andersen
A common complaint from children is growing pains: a mild to severe pain located primarily in the legs and being most intense in evenings and during sleep. The diagnosis is based on the characteristics of the pain and careful clinical examination. The pain disappears as the child grows up. Research has suggested that the pain occurs more often in children who suffer from vitamin D deficiency, low bone density, low pain threshold, restless legs syndrome and in children who were breastfed for less than 40 days from birth...
April 17, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28413399/hsv-1-hsv-2-infection-related-cancers-in-bantu-populations-driving-hiv-1-prevalence-in-africa-tracking-the-origin-of-aids-at-the-onset-of-the-20th-century
#15
Jacqueline Le Goaster, Patrice Bouree, Franck N El Sissy, Florence Phuong Bui, Johanna Pokossy Epee, Paul Rollin, Frédéric Tangy, Anne-Lise Haenni
INTRODUCTION: At the onset of the 20th century, ancient clinical observations of cancer epidemics in Bantu populations of Sub-Saharan Africa were discovered. They were reported from 1914 to 1960, but remained unexplained. In 1983, in San Francisco, Calif., USA, cancer epidemics were related to infections by the human immunodeficiency virus type 1 (HIV-1) known as AIDS disease. Yet since 1996, it is known that HIV-1 strains are not the only ones involved. In Sub-Saharan Africa, recurrent orobuccal herpes simplex virus type 1 (HSV-1) and genital recurrent herpes simplex virus type 2 (HSV-2) appeared many times prior to infection by HIV-1...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/28413003/induced-pluripotent-stem-cells-derived-from-a-patient-with-autosomal-dominant-familial-neurohypophyseal-diabetes-insipidus-caused-by-a-variant-in-the-avp-gene
#16
Lise Bols Toustrup, Yan Zhou, Helene Kvistgaard, Niels Gregersen, Søren Rittig, Lars Aagaard, Thomas Juhl Corydon, Yonglun Luo, Jane H Christensen
Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by variants in the arginine vasopressin (AVP) gene. Here we report the generation of induced pluripotent stem cells (iPSCs) from a 42-year-old man carrying an adFNDI causing variant in exon 1 of the AVP gene using lentivirus-mediated nuclear reprogramming. The iPSCs carried the expected variant in the AVP gene. Furthermore, the iPSCs expressed pluripotency markers; displayed in vitro differentiation potential to the three germ layers and had a normal karyotype consistent with the original fibroblasts...
March 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28412928/poplar-stem-transcriptome-is-massively-remodelled-in-response-to-single-or-repeated-mechanical-stimuli
#17
Lise Pomiès, Mélanie Decourteix, Jérôme Franchel, Bruno Moulia, Nathalie Leblanc-Fournier
BACKGROUND: Trees experience mechanical stimuli -like wind- that trigger thigmomorphogenetic syndrome, leading to modifications of plant growth and wood quality. This syndrome affects tree productivity but is also believed to improve tree acclimation to chronic wind. Wind is particularly challenging for trees, because of their stature and perenniality. Climate change forecasts are predicting that the occurrence of high wind will worsen, making it increasingly vital to understand the mechanisms regulating thigmomorphogenesis, especially in perennial plants...
April 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28412033/antagonism-of-vasopressin-v2-receptor-improves-albuminuria-at-the-early-stage-of-diabetic-nephropathy-in-a-mouse-model-of-type-2-diabetes
#18
Ray El Boustany, Christopher Taveau, Catherine Chollet, Gilberto Velho, Lise Bankir, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby
AIMS: Vasopressin is increased in diabetes and was shown to contribute to development of diabetic nephropathy through V2 receptor (V2R) activation in an experimental model of type 1 diabetes. The role of V2R in type 2 diabetes remains undocumented. This study addresses the issue in a mouse model of type 2 diabetes. METHODS: Male obese diabetic db/db mice were treated for 12weeks with a selective V2R antagonist (SR121463) and compared to non-treated db/db and non-diabetic db/m mice...
April 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28411084/pelvic-tuberculosis-mimicking-deep-endometriosis
#19
Antoine Koch, Lise Lecointre, Olivier Garbin
Pelvic tuberculosis is most frequently observed in developing countries and often leads to the misdiagnosis of pelvic malignancy. We report the first case of pelvic tuberculosis mimicking deep endometriosis.
April 11, 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28410619/foxo1-pxk-pycard-and-samd9l-are-differentially-expressed-by-fibroblast-like-cells-in-equine-synovial-membrane-compared-to-joint-capsule
#20
Line Nymann Thomsen, Preben Dybdahl Thomsen, Alison Downing, Richard Talbot, Lise Charlotte Berg
BACKGROUND: The synovial membrane lines the luminal side of the joint capsule in synovial joints. It maintains joint homeostasis and plays a crucial role in equine joint pathology. When trauma or inflammation is induced in a joint, the synovial membrane influences progression of joint damage. Equine synovial membrane research is hampered by a lack of markers of fibroblast-like synoviocytes (FLS) to distinguish FLS from other fibroblast-like cells in musculoskeletal connective tissues...
April 14, 2017: BMC Veterinary Research
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