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https://www.readbyqxmd.com/read/29775511/optimized-fibril-network-morphology-by-precise-side-chain-engineering-to-achieve-high-performance-bulk-heterojunction-organic-solar-cells
#1
Tao Liu, Lijun Huo, Sreelakshmi Chandrabose, Kai Chen, Guangchao Han, Feng Qi, Xiangyi Meng, Dongjun Xie, Wei Ma, Yuanping Yi, Justin M Hodgkiss, Feng Liu, Jing Wang, Chuluo Yang, Yanming Sun
A polymer fibril assembly can dictate the morphology framework, in forming a network structure, which is highly advantageous in bulk heterojunction (BHJ) organic solar cells (OSCs). A fundamental understanding of how to manipulate such a fibril assembly and its influence on the BHJ morphology and device performance is crucially important. Here, a series of donor-acceptor polymers, PBT1-O, PBT1-S, and PBT1-C, is used to systematically investigate the relationship between molecular structure, morphology, and photovoltaic performance...
May 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29775277/cid-9998128-compound-is-a-potential-multi-target-drug-for-alzheimer-s-disease
#2
Nguyen Quoc Thai, Zuzana Bednarikova, Miroslav Gancar, Huynh Quang Linh, Chin-Kun Hu, Mai Suan Li, Zuzana Gazova
We have probed capability of small CID 9998128 compound as a potential multi-target drug for the Alzheimer's disease (AD) using in silico and in vitro experiments. By all-atom simulation and MM-PBSA method we have demonstrated that this compound strongly binds to both amyloid beta 42 (Aβ42 ) fibrils and β-secretase and the van der Waals interaction is dominating over the electrostatic interaction in binding affinity. A detailed analysis at the atomic level revealed that indazole in CID 99998128 structure made a major contribution to instability of all studied complexes...
May 18, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29774336/raman-fingerprints-of-amyloid-structures
#3
Jessica D Flynn, Jennifer C Lee
Structural differences in pathological and functional amyloid fibrils have been investigated by Raman microspectroscopy. Second-derivative analyses of amide-I and amide-III bands distinguish parallel in-register β-sheets from a β-solenoid. Further, spatially resolved Raman spectra reveal molecular heterogeneity in amyloid structures.
May 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29772895/reversible-assembly-of-a-drug-peptide-into-amyloid-fibrils-a-dynamic-circular-dichroism-study
#4
Frédéric Gobeaux, Frank Wien
The common view on the amyloid fibril formation is that it is a multistep process that involves many oligomeric intermediate species, which leads to a high degree of polymorphism. This view derives from numerous kinetic studies whose vast majority was carried out with amyloid β fragments or other pathological amyloidogenic sequences. Yet, it is not clear whether the mechanisms inferred from these studies are universal and also apply to functional amyloids, in particular to peptide hormones which form reversible amyloid structures...
May 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29772384/facile-preparation-of-biocompatible-poly-lactic-acid-reinforced-poly-%C3%AE%C2%B5-caprolactone-fibers-via-graphite-nanoplatelets-aided-melt-spinning
#5
Ivan Kelnar, Alexander Zhigunov, Ludmila Kaprálková, Ivan Fortelný, Jiří Dybal, Jaroslav Kratochvíl, Martina Nevoralová, Marcela Hricová, Viera Khunová
Addition of high-aspect-ratio (AR) nanofillers can markedly influence flow behavior of polymer systems. As a result, application of graphite nanoplatelets (GNP) allows preparation of microfibrillar composites (MFC) based on PCL matrix reinforced with in-situ generated PLA fibrils. This work deals, for the first time, with preparation of analogous melt-drawn fibers. Unlike other blend-based fibers, the spinning and melt drawing leads to structure of deformed inclusions due to unfavorable ratio of rheological parameters of components...
May 9, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29771495/rapid-growth-of-acetylated-a%C3%AE-16-20-into-macroscopic-crystals
#6
Christian Bortolini, Lasse Hyldgaard Klausen, Søren Vrønning Hoffmann, Nykola C Jones, Daniela Saadeh, Zegao Wang, Tuomas P J Knowles, Mingdong Dong
Aberrant assembly of the amyloid-β (Aβ) is responsible for the development of Alzheimer's disease, but can also be exploited to obtain highly functional biomaterials. The short Aβ fragment, KLVFF (Aβ16-20), is crucial for Aβ assembly and considered to be an Aβ aggregation inhibitor. Here, we show that acetylation of KLVFF turns it into an extremely fast self-assembling molecule, reaching macroscopic (i.e. mm) size in seconds. We show that KLVFF is metastable and that the self-assembly can be directed towards a crystalline or fibrillar phase simply through chemical modification, via acetylation or amidation of the peptide...
May 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29767501/enhanced-antimicrobial-activity-and-structural-transitions-of-a-nanofibrillated-cellulose-nisin-bio-composite-suspension
#7
Ramon Weishaupt, Lukas Heuberger, Gilberto Siqueira, Beatrice Gutt, Tanja Zimmermann, Katharina Maniura-Weber, Stefan Salentinig, Greta Faccio
The occurrence of resistance to antibiotics has posed a high demand for novel strategies to fight bacterial infections. Antimicrobial peptides (AMPs) are a promising alternative to con-ventional antibiotics. However, their poor solubility in water and sensitivity to degradation has limited their application. Here we report the design of a smart, pH-responsive antimicro-bial nanobiocomposite material based on the AMP nisin and oxidized nanofibrillated cellulose (TONFC). Morphological transformations of the nano-scale structure of nisin functionalized TONFC fibrils were discovered at pH values between pH 5...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29762014/selective-and-sensitive-pull-down-of-amyloid-fibrils-produced-in-vitro-and-in-vivo-by-the-use-of-pentameric-thiophene-coupled-resins
#8
Anna Beatriz Wreden, Luiza Fernandes, Mirian Kelley, Antônio Pereira-Neves, Caroline S Moreira, David R da Rocha, Fernando L Palhano
Protein aggregation is a hallmark of several degenerative diseases, including Alzheimer's disease, Parkinson's disease and familial amyloidosis (Finnish type) (FAF). A method to isolate and detect amyloids is desired for the diagnosis of amyloid diseases. Here, we report the synthesis of pentameric thiophene amyloid ligand (p-FTAA) linked to agarose resin for selective purification of amyloid aggregates produced in vitro and in vivo. Using amyloid fibrils produced in vitro from alpha-synuclein, gelsolin and Aβ1-40 and gelsolin amyloid aggregates extracted from tissue homogenates of a mouse model of FAF, we observed that p-FTAA resin was able to pull down amyloid aggregates...
May 15, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29760849/acute-pulmonary-embolism-in-emergency-department-patients-despite-therapeutic-anticoagulation
#9
Michelle Y Liu, Dustin W Ballard, Jie Huang, Adina S Rauchwerger, Mary E Reed, Sean C Bouvet, David R Vinson
Introduction: Emergency department (ED) patients with acute pulmonary embolism (PE) despite therapeutic anticoagulation at the time of diagnosis are uncommonly encountered and present a diagnostic and management challenge. Their characterization and outcomes are poorly described. We sought to describe the prevalence and characteristics of therapeutically anticoagulated patients among a population of patients with acute PE in a community setting and to describe treatment changes and 30-day outcomes...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29759774/assessment-of-left-atrial-fibrosis-by-late-gadolinium-enhancement-magnetic-resonance-imaging-methodology-and-clinical-implications
#10
REVIEW
Johannes Siebermair, Eugene G Kholmovski, Nassir Marrouche
Recently, studies using late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) to identify structural changes of atrial tissue have contributed significantly to understanding the pathophysiology and progression of atrial fibrillation (AF). Moreover, imaging of atrial fibrosis using MRI has evolved to be a tool to improve clinical outcome of AF ablation procedures by allowing a patient-specific individualized management approach. LGE-MRI has been shown to predict AF ablation outcome based on pre-procedural imaging to define the extent of atrial fibrosis...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29758157/nanocellulose-fragmentation-mechanisms-and-inversion-of-chirality-from-the-single-particle-to-the-cholesteric-phase
#11
Gustav Nystrom, Mario Arcari, Jozef Adamcik, Ivan Usov, Raffaele Mezzenga
Understanding how nanostructure and nanomechanics influence physical material properties on the micro- and macroscale is an essential goal in soft condensed matter research. Mechanisms governing fragmentation and chirality inversion of filamentous colloids are of specific interest because of their critical role in load-bearing and self-organizing functionalities of soft nanomaterials. Here we provide a fundamental insight into the self-organization across several length scales of nanocellulose, an important bio-colloid system with wide-ranging applications as structural, insulating and functional material...
May 14, 2018: ACS Nano
https://www.readbyqxmd.com/read/29754661/catheter-ablation-versus-antiarrhythmic-drug-therapy-for-atrial-fibrillation-cabana-trial-study-rationale-and-design
#12
Douglas L Packer, Daniel B Mark, Richard A Robb, Kristi H Monahan, Tristram D Bahnson, Kathleen Moretz, Jeanne E Poole, Alice Mascette, Yves Rosenberg, Neal Jeffries, Hussein R Al-Khalidi, Kerry L Lee
The Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation (CABANA,NCT00911508)(1) trial is testing the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of eliminating atrial fibrillation (AF) is superior to current state-of-the-art pharmacologic therapy. This international 140-center clinical trial was designed to randomize 2200 patients to a strategy of catheter ablation versus state-of-the-art rate or rhythm control drug therapy. Inclusion criteria include: 1) age> 65, or ≤65 with≥ 1 risk factor for stroke, 2) documented AF warranting treatment, and 3) eligibility for both catheter ablation and≥ 2 anti-arrhythmic or≥ 2 rate control drugs...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29753045/identification-and-functional-characterization-of-zebrafish-k-2p-17-1-task-4-talk-2-two-pore-domain-k-channels
#13
Ingo Staudacher, Claudius Illg, Jakob Gierten, Sebastian Seehausen, Patrick A Schweizer, Hugo A Katus, Dierk Thomas
Human K2P 17.1 (TASK-4, TALK-2) two-pore-domain potassium (K2P ) channels have recently been implicated in heart rhythm disorders including atrial fibrillation and conduction disease. The functional in vivo significance of K2P 17.1 currents in cardiac electrophysiology remains incompletely understood. Danio rerio (zebrafish) may be utilized to elucidate the role of cardiac K2P channels in vivo. The aim of this work was to identify and characterize the zebrafish ortholog of K2P 17.1 in comparison to its human counterpart...
May 9, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29752376/effects-of-prolonged-spaceflight-on-atrial-size-atrial-electrophysiology-and-risk-of-atrial-fibrillation
#14
Htet W Khine, Katarina Steding-Ehrenborg, Jeffrey L Hastings, Jamie Kowal, James D Daniels, Richard L Page, Jeffery J Goldberger, Jason Ng, Beverley Adams-Huet, Michael W Bungo, Benjamin D Levine
BACKGROUND: The prevalence of atrial fibrillation (AF) in active astronauts is ≈5%, similar to the general population but at a younger age. Risk factors for AF include left atrial enlargement, increased number of premature atrial complexes, and certain parameters on signal-averaged electrocardiography, such as P-wave duration, root mean square voltage for the terminal 20 ms of the signal-averaged P wave, and P-wave amplitude. We aimed to evaluate changes in atrial structure, supraventricular beats, and atrial electrophysiology to determine whether spaceflight could increase the risk of AF...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29751013/the-properties-of-amyloid-%C3%AE-fibrils-are-determined-by-their-path-of-formation
#15
Kristoffer Brännström, Tohidul Islam, Anna L Gharibyan, Irina Iakovleva, Lina Nilsson, Cheng Choo Lee, Linda Sandblad, Annelie Pamrén, Anders Olofsson
Fibril formation of the amyloid-β peptide (Aβ) follows a nucleation-dependent polymerization process and is associated with Alzheimer's disease. Several different lengths of Aβ are observed in vivo, but Aβ1-40 and Aβ1-42 are the dominant forms. The fibril architectures of Aβ1-40 and Aβ1-42 differ and Aβ1-42 assemblies are generally considered more pathogenic. We show here that monomeric Aβ1-42 can be cross-templated and incorporated into the ends of Aβ1-40 fibrils, while incorporation of Aβ1-40 monomers into Aβ1-42 fibrils is very poor...
May 8, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29750500/a-hydrogel-of-ultrathin-pure-polyaniline-nanofibers-oxidant-templating-preparation-and-supercapacitor-application
#16
Kun Zhou, Yuan He, Qingchi Xu, Qin'e Zhang, An'an Zhou, Zihao Lu, Li-Kun Yang, Yuan Jiang, Dongtao Ge, Xiang Yang Liu, Hua Bai
Although challenging, fabrication of porous conducting polymeric materials with excellent electronic properties is crucial for many applications. We developed a fast in-situ polymerization approach to pure polyaniline (PANI) hydrogels, with vanadium pentoxide hydrate nanowires as both the oxidant and sacrifice template. A network comprised of ultrathin PANI nanofibers was generated during the in-situ polymerization, and the large aspect ratio of these PANI nanofibers allowed the formation of hydrogels at a low solid content of 1...
May 11, 2018: ACS Nano
https://www.readbyqxmd.com/read/29749941/the-impact-of-atrial-fibrillation-clinical-subtype-on-mortality
#17
Melissa Leung, Philippe J van Rosendael, Rachid Abou, Nina Ajmone Marsan, Dominic Y Leung, Victoria Delgado, Jeroen J Bax
OBJECTIVES: This study sought to investigate the prognostic implications of the clinical subtype of atrial fibrillation (AF): paroxysmal or persistent. BACKGROUND: Underlying structural abnormalities of the left atrium may be responsible for the initial clinical presentation of AF in either paroxysmal or persistent form, yet the prognostic implications of the clinical subtype on presentation are unknown. METHODS: Over a median of 7 years, 1,773 patients (age 64 ± 12 years, 74% males) with nonvalvular AF with index presentations for paroxysmal or persistent AF were followed for the occurrence of all-cause mortality...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29748322/near-atomic-model-of-microtubule-tau-interactions
#18
Elizabeth H Kellogg, Nisreen M A Hejab, Simon Poepsel, Kenneth H Downing, Frank DiMaio, Eva Nogales
Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer's disease. It is unclear which tau residues are crucial for tau-MT interactions, where tau binds on MTs, and how it stabilizes them. We used cryo-electron microscopy to visualize different tau constructs on MTs, and computational approaches to generate atomic models of tau-tubulin interactions...
May 10, 2018: Science
https://www.readbyqxmd.com/read/29748195/does-high-intensity-endurance-training-increase-the-risk-of-atrial-fibrillation-a-longitudinal-study-of-left-atrial-structure-and-function
#19
Mildred A Opondo, Norman Aiad, Matthew A Cain, Satyam Sarma, Erin Howden, Douglas A Stoller, Jason Ng, Pieter van Rijckevorsel, Michinari Hieda, Takashi Tarumi, M Dean Palmer, Benjamin D Levine
BACKGROUND: Exercise mitigates many cardiovascular risk factors associated with atrial fibrillation. Endurance training has been associated with atrial structural changes which can increase the risk for atrial fibrillation. The dose of exercise training required for these changes is uncertain. We sought to evaluate the impact of exercise on left atrial (LA) mechanical and electrical function in healthy, sedentary, middle-aged adults. METHODS: Sixty-one adults (52±5 years) were randomized to either 10 months of high-intensity exercise training or yoga...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29747822/ganglioside-mediated-assembly-of-amyloid-%C3%AE-protein-roles-in-alzheimer-s-disease
#20
Katsumi Matsuzaki, Koichi Kato, Katsuhiko Yanagisawa
Assembly and deposition of amyloid β-protein (Aβ) is an early and invariable pathological event of Alzheimer's disease (AD), a chronic neurodegenerative disease affecting the neurons in the brain of aging population. Thus, clarification of the molecular mechanism underlying Aβ assembly is crucial not only for understanding the pathogenesis of AD, but also for developing disease-modifying remedies. In 1995, ganglioside-bound Aβ (GAβ), with unique molecular characteristics, including its altered immunoreactivity and its conspicuous ability to accelerate Aβ assembly, was discovered in an autopsied brain showing early pathological changes of AD...
2018: Progress in Molecular Biology and Translational Science
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