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CKD biomarkers

Jean A Hall, Dale A Fritsch, Dennis E Jewell, Patricia A Burris, Kathy L Gross
A prospective, randomised, 6-month feeding trial was performed in 28 adult cats with International Renal Interest Society (IRIS) stage 1 and 2 chronic kidney disease (CKD). All cats were assigned to either a control food: Royal Canin Renal Support A Feline, dry or a test food: Hill's Prescription Diet k/d Feline with chicken, dry. Food intake was recorded daily; body weight weekly; and serum, urine, dual-energy x-ray absorptiometry (DEXA) and body condition assessments were performed at 0, 1, 3 and 6 months...
December 4, 2018: Veterinary Record
Petter Bjornstad, Pattara Wiromrat, Richard J Johnson, Rachel Sippl, David Z Cherney, Randy Wong, Marian J Rewers, Janet K Snell-Bergeon
OBJECTIVE: Novel biomarkers are needed to better predict coronary artery calcification (CAC), a marker of subclinical atherosclerosis, and diabetic kidney disease (DKD) in type 1 diabetes. We evaluated the associations between serum uromodulin (SUMOD [a biomarker associated with anti-inflammatory and renal protective properties]), CAC progression and DKD development over 12 years. RESEARCH DESIGN AND METHODS: Participants ( n = 527, 53% females) in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study were examined during 2002-2004, at a mean age of 39...
November 27, 2018: Diabetes Care
Marta Esgalhado, Julie A Kemp, Renata Azevedo, Bruna R Paiva, Milena B Stockler-Pinto, Carla J Dolenga, Natália A Borges, Lia S Nakao, Denise Mafra
An imbalance of gut microbiota is considered a new cardiovascular risk factor for chronic kidney disease (CKD) patients, since it is directly associated with increased uremic toxin production, inflammation and oxidative stress. Strategies such as prebiotic supplementation have been suggested to mitigate these complications. We hypothesized that prebiotic-resistant starch could ameliorate uremic toxins levels, oxidative stress, and inflammatory states in hemodialysis (HD) patients. This pilot study evaluated 31 HD patients assigned to either resistant starch (16 g of resistant starch Hi-Maize® 260) or placebo (manioc flour) supplementation, which they received for 4 weeks on alternate days through cookies on dialysis days and powder in a sachet on non-dialysis days...
November 23, 2018: Food & Function
Jing Lin, Huacai Zhao, Fuyong Jiao, Lei Ma, Le Ma
The aim of the study was to identify whether lymphocyte hydrogen sulfide production is a potential biomarker to predict intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD).This preliminary, single-center, case-control study conducted between June 2016 and March 2018 in Shaanxi Provincial People's Hospital, 85 children (50 with KD and 35 healthy controls) were included. Laboratory biomarkers were collected from the medical records. All patients with KD received 1 g/kg/d IVIG for 2 days and 30-50 mg/kg/d oral aspirin...
November 2018: Medicine (Baltimore)
Ashok Kumar Yadav, Sanveer Tiwana, Matthew Steel, Raja Ramachandran, Juan C Kaski, Vivekanand Jha, Debasish Banerjee
PURPOSE: CKD patients after kidney transplantation continue to suffer from elevated CV events which may be related to low vitamin D and its adverse impact on vascular function. The prevalence of vitamin D deficiency in North Indian kidney transplantation patients and its impact on vascular and bone biomarkers is unknown which this study investigated. METHODS: Non-diabetic, stable, > 6 months post-kidney transplantation patients, not on vitamin D supplementation, were recruited after informed consent...
November 19, 2018: International Urology and Nephrology
Maciej Fijałkowski, Joanna Stępniewska, Maciej Domański, Kazimierz Ciechanowski, Edyta Golembiewska
Eicosanoids are biologically active molecules that are created in the process of oxidation of arachidonic acid (AA) which is a constituent of the cell membrane phospholipids. Throughout the years it was evidenced by experiments that the lipid and lipid-derived metabolites play an important role in physiological and pathological processes in the kidneys. They are being considered as biomarkers in detecting acute kidney injury, nephrotoxicity, glomerulonephritis and early stages of diabetic nephropathy because of their participation in inflammatory processes and in oxidative stress...
November 19, 2018: Acta Biochimica Polonica
Paulo Giovanni de Albuquerque Suassuna, Rogério Baumgratz de Paula, Hélady Sanders-Pinheiro, Orson W Moe, Ming-Chang Hu
Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF family that acts as a metabolic regulator of both glucose and lipid metabolism. Similar to fibroblast growth factor 23 (FGF23), serum FGF21 levels rise progressively with the loss of renal function, reaching 20 times normal values in end-stage renal disease. In patients with chronic kidney disease (CKD), higher serum FGF21 levels correlate with poorer metabolic profile, higher inflammatory markers, more comorbidities, and higher mortality...
November 14, 2018: Journal of Nephrology
Katie L Connor, Laura Denby
Accurate biomarkers that both predict the progression to, and detect the early stages of chronic kidney disease (CKD) are lacking, resulting in difficulty in identifying individuals who could potentially benefit from targeted intervention. In a recent issue [ Clinical Science (2018) 132 , 2121-2133], Cui et al. examine the ability of urinary angiotensinogen (uAGT) to predict the progression of acute kidney injury (AKI) to CKD. They principally employ a murine ischaemia reperfusion injury model to study this and provide data from a small prospective study of patients with biopsy proven acute tubular necrosis...
November 15, 2018: Clinical Science (1979-)
Chih-Chao Yang, Yen-Ta Chen, Christopher Glenn Wallace, Kuan-Hung Chen, Ben-Chung Cheng, Pei-Hsun Sung, Yi-Chen Li, Sheung-Fat Ko, Hsueh-Wen Chang, Hon-Kan Yip
This study tested the hypothesis that early administration of empagliflozin (Empa), an inhibitor of glucose recycling in renal tubules, could preserve heart function in cardiorenal syndrome (CRS) in rat. Chronic kidney disease (CKD) was caused by 5/6 subtotal nephrectomy and dilated cardiomyopathy (DCM) by doxorubicin (DOX) treatment. In vitro results showed that protein expressions of cleaved-caspase3 and autophagy activity at 24 h/48 h in NRK-52P cells were significantly upregulated by para-Creso treatment; these were significantly downregulated by Empa treatment...
November 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sara Nuovo, Laura Fuiano, Alessia Micalizzi, Roberta Battini, Enrico Bertini, Renato Borgatti, Gianluca Caridi, Stefano D'Arrigo, Elisa Fazzi, Rita Fischetto, Gian Marco Ghiggeri, Lucio Giordano, Vincenzo Leuzzi, Romina Romaniello, Sabrina Signorini, Gilda Stringini, Ginevra Zanni, Marta Romani, Enza Maria Valente, Francesco Emma
Background: Joubert syndrome (JS) is an inherited ciliopathy characterized by a complex midbrain-hindbrain malformation and multiorgan involvement. Renal disease, mainly juvenile nephronophthisis (NPH), was reported in 25-30% patients although only ∼18% had a confirmed diagnosis of chronic kidney disease (CKD). NPH often remains asymptomatic for many years, resulting in delayed diagnosis. The aim of the study was to identify a biomarker able to quantify the risk of progressive CKD in young children with JS...
November 6, 2018: Nephrology, Dialysis, Transplantation
Maëlle Plawecki, Marion Morena, Nils Kuster, Leila Chenine, Hélène Leray-Moragues, Bernard Jover, Pierre Fesler, Manuela Lotierzo, Anne-Marie Dupuy, Kada Klouche, Jean-Paul Cristol
Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression of tumorigenicity 2 (sST2) biomarker is well identified in risk stratification of cardiovascular (CV) events in heart failure. Furthermore, sST2 is included in a bioclinical score to stratify mortality risk...
2018: Mediators of Inflammation
Radmila Žeravica, Branislava Ilinčić, Velibor Čabarkapa, Isidora Radosavkić, Jelena Samac, Katarina Nikoletić, Zoran Stošić
AIM: Elevated fractional excretion of magnesium (FEMg) is a noninvasive biomarker of kidney damage, but its association with kidney functional parameters in nondiabetic chronic kidney disease (CKD) patients has not been sufficiently explored thus far. METHODS: We enrolled 111 adult patients with nondiabetic CKD and 30 controls. To precisely investigate kidney function, the following parameters were assessed measured glomerular filtration rate (mGFR), effective renal plasma flow (ERPF), Cystatin C, albuminuria, and fractional excretion of magnesium (FEMg)...
May 1, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Josef van Helden, Ralf Weiskirchen
There is growing interest in measuring plasma fibroblast growth factor 23 (FGF23) concentrations in a number of clinical settings. However, a reliable assay with acceptable performance is lacking. Plasma samples of healthy adults and patients with different stages of chronic kidney disease (CKD) were used to compare the precision, recovery, linearity and the pre-analytical stability characteristics of a new fully automated FGF23 (intact) assay with a commercially available FGF23 (intact) ELISA. Method agreement was evaluated, reference and stage-specific ranges for kidney disease were established...
October 31, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
María E Rodríguez-Ortiz, Claudia Pontillo, Mariano Rodríguez, Petra Zürbig, Harald Mischak, Alberto Ortiz
Chronic kidney disease is associated with increased risk of CKD progression and death. Therapeutic approaches to limit progression are limited. Developing tools for the early identification of those individuals most likely to progress will allow enriching clinical trials in high risk early CKD patients. The CKD273 classifier is a panel of 273 urinary peptides that enables early detection of CKD and prognosis of progression. We have generated urine capillary electrophoresis-mass spectrometry-based peptidomics CKD273 subclassifiers specific for CKD stages to allow the early identification of patients at high risk of CKD progression...
October 29, 2018: Scientific Reports
Lijun Ma, Jasmin Divers, Barry I Freedman
BACKGROUND: An improved understanding of the pathogenesis in apolipoprotein L1 gene (APOL1)-gene associated chronic kidney disease (CKD) arose from observations in kidney transplantation. APOL1 genotyping could soon improve the safety of living kidney donation in individuals with recent African ancestry and alter the allocation of deceased donor kidneys. METHODS: This manuscript reviews the potential mechanisms that underlie development of APOL1-associated nephropathy...
October 27, 2018: Transplantation
Daniel Kraus, Beatrice von Jeinsen, Stergios Tzikas, Lars Palapies, Tanja Zeller, Christoph Bickel, Georg Fette, Karl J Lackner, Christiane Drechsler, Johannes T Neumann, Stephan Baldus, Stefan Blankenberg, Thomas Münzel, Christoph Wanner, Andreas M Zeiher, Till Keller
Background Patients with chronic kidney disease ( CKD ) are at high risk of myocardial infarction. Cardiac troponins are the biomarkers of choice for the diagnosis of acute myocardial infarction ( AMI ) without ST -segment elevation ( NSTE ). In patients with CKD , troponin levels are often chronically elevated, which reduces their diagnostic utility when NSTE - AMI is suspected. The aim of this study was to derive a diagnostic algorithm for serial troponin measurements in patients with CKD and suspected NSTE - AMI ...
October 2, 2018: Journal of the American Heart Association
Huimin Chen, Ying Cui, Changying Xing, Yogendranath Purrunsing, Xiaoming Zha, Chong Shen, Ming Zeng, Guang Yang, Xiangbao Yu, Lina Zhang, Yao Jiang, Zhixiang Shen, Haoyang Ma, Caixia Yin, Yunfei Li, Ningning Wang
PURPOSE: Decreased heart rate variability (HRV) is closely related to abnormal cardiac autonomic nervous function, especially sympathetic hyperactivity, which intensifies the risk of cardiovascular events and sudden death. HRV parameters are lower in chronic kidney disease (CKD) and parathyroidectomy (PTX) can improve these abnormalities in severe secondary hyperparathyroidism (SHPT) patients. However, few studies have evaluated correlations between circulating bone markers and HRV in CKD patients...
December 2018: International Urology and Nephrology
X J Ye, S H Cui, J W Song, K Liu, X Y Huang, L Wang, Y J Zhou, Z H Yan, G B Wang
AIM: To investigate the clinical value of diffusion tensor imaging (DTI) in assessing renal function changes in diabetic patients with early-stage chronic kidney disease (CKD), and the relationship of DTI parameters with estimated glomerular filtration rate (eGFR) and urinary biomarkers. MATERIALS AND METHODS: Thirty-six patients with diabetes mellitus (DM; 30 CKD stage 1 and 6 CKD stage 2) and 26 healthy control subjects were enrolled. DTI was performed using a clinical 3 T MRI system...
October 22, 2018: Clinical Radiology
M Cañadas-Garre, K Anderson, J McGoldrick, A P Maxwell, A J McKnight
BACKGROUND: Chronic kidney disease (CKD) is recognised as a global public health problem, more prevalent in older persons and associated with multiple co-morbidities. Diabetes mellitus and hypertension are common aetiologies for CKD, but IgA glomerulonephritis, membranous glomerulonephritis, lupus nephritis and autosomal dominant polycystic kidney disease are also common causes of CKD. MAIN BODY: Conventional biomarkers for CKD involving the use of estimated glomerular filtration rate (eGFR) derived from four variables (serum creatinine, age, gender and ethnicity) are recommended by clinical guidelines for the evaluation, classification, and stratification of CKD...
October 25, 2018: Journal of Translational Medicine
William R Zhang, Timothy E Craven, Rakesh Malhotra, Alfred K Cheung, Michel Chonchol, Paul Drawz, Mark J Sarnak, Chirag R Parikh, Michael G Shlipak, Joachim H Ix
Background: Whether the increased incidence of chronic kidney disease (CKD) during intensive systolic blood pressure (SBP) lowering is accompanied by intrinsic kidney injury is unknown. Objective: To compare changes in kidney damage biomarkers between incident CKD case participants and matched control participants as well as between case participants in the intensive (<120 mm Hg) versus the standard (<140 mm Hg) SBP management groups of SPRINT (Systolic Blood Pressure Intervention Trial)...
October 23, 2018: Annals of Internal Medicine
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