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CKD biomarkers

Tomasz Charytoniuk, Maciej Małyszko, Jan Bączek, Piotr Fiedorczyk, Karolina Siedlaczek, Jolanta Małyszko
Nephrectomy, which constitutes a gold-standard procedure for the treatment of renal-cell carcinoma (RCC), has been widely discussed in the past decade as a significant risk factor of the development of chronic kidney disease (CKD). RCC is the third most common genitourinary cancer in the United States, with an estimated more than 65,000 new cases and 14,970 deaths. The aim of this review was to precisely and comprehensively summarize the status of current knowledge in chronic kidney disease risk factors after nephrectomy, the advantages of minimally invasive vs...
August 14, 2018: Postgraduate Medicine
Mateusz Maciejczyk, Julita Szulimowska, Anna Skutnik, Katarzyna Taranta-Janusz, Anna Wasilewska, Natalia Wiśniewska, Anna Zalewska
There are still missing non-invasive biomarkers of chronic kidney disease (CKD) in children. Therefore, the aim of the study was to evaluate oxidative stress indicators in the non-stimulated (NWS) and stimulated saliva (SWS) of CKD children ( n = 25) and healthy controls ( n = 25). Salivary antioxidants (catalase (CAT), peroxidase (Px), superoxide dismutase (SOD), uric acid (UA), reduced glutathione (GSH), albumin), redox status (total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI)), and oxidative damage products (advanced glycation end products (AGE), advanced oxidation protein products (AOPP), malondialdehyde (MDA)) were evaluated...
August 10, 2018: Journal of Clinical Medicine
Kyoko Okada, Motohiro Sekino, Hiroyuki Funaoka, Shuntaro Sato, Taiga Ichinomiya, Hiroaki Murata, Takuji Maekawa, Masaharu Nishikido, Kiyoyuki Eishi, Tetsuya Hara
BACKGROUND: Intestinal fatty acid-binding protein (I-FABP), a biomarker of enterocyte injury, has been reported to be a diagnostic marker of intestinal ischemia and a prognostic marker in critically ill patients. However, the kinetics of I-FABP in renal failure patients is unknown. We sought to identify I-FABP levels in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) on hemodialysis (HD) and to identify the manner in which the I-FABP levels change. MATERIALS AND METHODS: Adult patients who were admitted for elective cardiac surgery with either normal renal function (NRF), CKD, or ESKD on HD were enrolled...
October 2018: Journal of Surgical Research
Keith Gillis, Kathryn K Stevens, Elizabeth Bell, Rajan K Patel, Alan G Jardine, Scott T W Morris, Markus P Schneider, Christian Delles, Patrick B Mark
Background: Premature cardiovascular disease in patients with chronic kidney disease (CKD) is not explained by traditional risk factors and oxidative stress may contribute via endothelial and vascular dysfunction. We investigated the effect of ascorbic acid on oxidative stress and vascular function in CKD patients compared with controls with hypertension (HTN). Methods: A crossover study of intravenous saline and ascorbic acid was conducted. Biomarkers of oxidative stress were measured, while pulse wave analysis and brachial flow - mediated dilatation were performed to assess large artery and endothelial function...
August 2018: Clinical Kidney Journal
Hengzhong Lun, Weihua Yang, Shuping Zhao, Meijie Jiang, Mingjie Xu, Fenfen Liu, Yunshan Wang
The present study aimed to determine the differences in gut microbiota between patients with chronic kidney disease (CKD) and healthy controls (HC) and search for better microbial biomarkers associated with CKD. The 16S rRNA gene sequencing approach was used to investigate the differences in gut microbiota between the CKD and HC groups. The study found that 12 phylotypes were overrepresented in the CKD group and 19 in the HC group at the genus level. Furthermore, genera Lachnospira and Ruminococcus_gnavus performed the best in differentiating between HC and CKD populations...
August 7, 2018: MicrobiologyOpen
Felix S Seibert, Maximilian Sitz, Jürgen Passfall, Martin Haesner, Peter Laschinski, Martin Buhl, Frederic Bauer, Nina Babel, Nikolaos Pagonas, Timm H Westhoff
BACKGROUND/AIMS: Urinary biomarkers like neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) do not only allow an early diagnosis of acute kidney injury, but also provide prognostic information in this setting. The present prospective study investigates, whether the urinary biomarkers NGAL, KIM-1 and calprotectin have prognostic information in chronic kidney disease (CKD) as well. METHODS: Urinary calprotectin, NGAL and KIM-1 concentrations were assessed in a study population of 143 patients with stable CKD comprising diabetic and hypertensive nephropathy, glomerulonephritis/vasculitis, and autosomal dominant polycystic kidney disease...
August 3, 2018: Kidney & Blood Pressure Research
Faeq Husain-Syed, Fiorenza Ferrari, Aashish Sharma, Tommaso Hinna Danesi, Pércia Bezerra, Salvador Lopez-Giacoman, Sara Samoni, Massimo de Cal, Valentina Corradi, Grazia Maria Virzì, Silvia De Rosa, María Jimena Muciño Bermejo, Carla Estremadoyro, Gianluca Villa, Jose J Zaragoza, Carlotta Caprara, Alessandra Brocca, Horst-Walter Birk, Hans-Dieter Walmrath, Werner Seeger, Federico Nalesso, Monica Zanella, Alessandra Brendolan, Davide Giavarina, Loris Salvador, Rinaldo Bellomo, Mitchell H Rosner, John A Kellum, Claudio Ronco
Background: Cardiac surgery is a leading cause of acute kidney injury (AKI). Such AKI patients may develop progressive chronic kidney disease (CKD). Others, who appear to have sustained no permanent loss of function (normal serum creatinine), may still lose renal functional reserve (RFR). Methods: We extended the follow-up in the observational 'Preoperative RFR Predicts Risk of AKI after Cardiac Surgery' study from hospital discharge to 3 months after surgery for 86 (78...
July 19, 2018: Nephrology, Dialysis, Transplantation
Rui Xi, Qin Fan, Xiaoxiang Yan, Hang Zhang, Hongyang Xie, Gang Gu, Yan Xu, Fang Wang, Rong Tao
Background: Several inflammatory factors have been demonstrated with diagnostic or prognostic value in patients with ischemic cardiomyopathy (ICM). Interleukin 34 (IL-34), an additional ligand of colony stimulating factor-1 receptor (CSF-1R), has been identified as a biomarker of coronary artery disease (CAD) and chronic kidney disease (CKD). However, the potential effect of IL-34 in ICM remains unknown. Methods: Serum IL-34 levels were detected in 360 subjects with ICM and in 465 subjects without ICM; the latter group included 233 controls without CAD and 232 patients with CAD and normal cardiac function...
2018: Frontiers in Physiology
Sushrut S Waikar, Casey M Rebholz, Zihe Zheng, Shelley Hurwitz, Chi-Yuan Hsu, Harold I Feldman, Dawei Xie, Kathleen D Liu, Theodore E Mifflin, John H Eckfeldt, Paul L Kimmel, Ramachandran S Vasan, Joseph V Bonventre, Lesley A Inker, Josef Coresh
RATIONALE & OBJECTIVE: Determining whether a change in estimated glomerular filtration rate (eGFR) or albuminuria is clinically significant requires knowledge of short-term within-person variability of the measurements, which few studies have addressed in the setting of chronic kidney disease. STUDY DESIGN: Cross-sectional study with multiple collections over less than 4 weeks. SETTING & PARTICIPANTS: Clinically stable outpatients with chronic kidney disease (N=50; mean age, 56...
July 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Takehiro Suzuki, Takaaki Abe
Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even after statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein...
August 2018: Kidney International
Ismail Kocyigit, Eray Eroglu, Ahmet Safa Kaynar, Derya Kocer, Seval Kargi, Gokmen Zararsiz, Ruslan Bayramov, Hakan Imamoglu, Murat Hayri Sipahioglu, Bulent Tokgoz, Munis Dundar, Oktay Oymak
BACKGROUND: The prominent features of autosomal dominant polycystic kidney disease (ADPKD) are early development of hypertension, chronic kidney disease and cardiovascular problems. Thus, we aimed to investigate the role of endothelin, a vascular biomarker, in the clinical course of ADPKD, including renal and cardiovascular survival. METHODS: In 138 patients with ADPKD and 28 healthy controls, we measured serum endothelin-1 (ET-1) levels by enzyme-linked immunosorbent assay (ELISA)...
July 18, 2018: Journal of Nephrology
Rayo Morfin-Otero, Elvira Garza-Gonzalez, Guillermo Garcia Garcia, Hector R Perez-Gomez, Sara A Aguirre-Diaz, Esteban Gonzalez-Diaz, Sergio Esparza-Ahumada, Alfonso Fernandez-Ramirez, Francisco Cardenas-Lara, Adrian Martinez-Melendez, Rodrigo Escobedo-Sanchez, Margarita Ibarra-Hernandez, Gerardo Leon Garnica, Eduardo Rodriguez-Noriega
BACKGROUND: Clostridium difficile infection (CDI) is a leading cause of healthcare-associated diarrhea worldwide. Patients with chronic kidney disease (CKD) are especially vulnerable, as they are exposed to CDI risk factors including frequent antibiotics. MATERIALS AND METHODS: In order to identify the risk factors for CDI in CKD patients, a 33-month long case-control study was carried out at a tertiary-care hospital in Mexico. CDI was confirmed at the genetic level, and univariate and multivariate analyses were performed to identify the association between risk factors, biomarkers, and outcome options (survival, relapse, death)...
July 19, 2018: Clinical Nephrology
Emanuela Valle, Liviana Prola, Diana Vergnano, Roberta Borghi, Fiammetta Monacelli, Nicola Traverso, Natascia Bruni, Andrea Bovero, Achille Schiavone, Joana Nery, Domenico Bergero, Patrizio Odetti
Objectives Cats are commonly affected by chronic kidney disease (CKD). Many reactive carbonyl intermediates and end products originating from the oxidative stress pathways are recognised as uraemic toxins and may play a role in CKD progression. The aim of the present study is to confirm whether carbonyl end-product formation is higher in cats affected by CKD and to assess whether an angiotensin-converting enzyme inhibitor (ACEi) might affect these hallmarks. Methods Twenty-two cats were divided into three groups: a control group (CG), cats with chronic kidney disease (CKD) and cats with chronic kidney disease treated with an ACEi...
July 1, 2018: Journal of Feline Medicine and Surgery
Geir Bjorklund, Erik Svanberg, Maryam Dadar, David J Card, Salvatore Chirumbolo, Dominic J Harrington, Jan Aaseth
Matrix Gla protein (MGP) is a vitamin K-dependent protein, which is synthesized in bone and many further mesenchymal cells, which is also highly expressed by vascular smooth 1muscle cells (VSMCs) and chondrocytes. Numerous studies have confirmed that MGP acts as a calcification-inhibitor although the mechanism of action is still not fully understood. The modulation of tissue calcification by MGP is potentially regulated in several ways including direct inhibition of calcium-phosphate precipitation, the formation of matrix vesicles (MVs), the formation of apoptotic bodies (ABs), and trans-differentiation of VSMCs...
July 15, 2018: Current Medicinal Chemistry
Tamara Milagres, Fernando E García-Arroyo, Miguel A Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G Sánchez-Lozada, Richard J Johnson, Carlos Roncal-Jimenez
BACKGROUND: Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have recently reported a model of CKD induced by heat stress. Here we test the hypothesis that rehydration with fructose may induce worse kidney injury than rehydration with equal amounts of water, and we also test if this fructose-induced injury is associated with activation of inflammasomes in the kidney...
July 13, 2018: BMC Nephrology
Natalia G Vallianou, Shah Mitesh, Agathoniki Gkogkou, Eleni Geladari
Chronic Kidney Disease is a growing health burden world widely. Traditional and mutual risk factors between CVD and CKD are age, hypertension, diabetes mellitus, dyslipidemia, tobacco use, family history and male gender. In this review, we will focus on whether or not early CKD is an important risk factor for the presence, severity and progression of CVD. Specifically, we will examine both traditional and novel risk factors of both CKD and CVD and how they relate to each other. We will also assess if early treatment of CKD, intensive compared to standard, has an important effect on the halt of the development of CKD as well as CVD...
July 11, 2018: Current Cardiology Reviews
K L Cheung, N A Zakai, P W Callas, G Howard, B K Mahmoodi, C A Peralta, S E Judd, M Kurella Tamura, M Cushman
BACKGROUND: Chronic kidney disease (CKD) is associated with venous thromboembolism (VTE) risk via unknown mechanisms. Whether factors associated with reduced VTE in the general population might also be associated with reduced risk in CKD is unknown. OBJECTIVES: To determine whether thrombosis biomarkers attenuate VTE risk and if factors associated with reduced VTE are similarly effective in CKD. METHODS: Baseline biomarkers were measured in a case-cohort (294 VTE cases, 939 non-cases) from the REGARDS study, a nationwide prospective cohort of 30,239 persons age ≥45 with 4...
July 8, 2018: Journal of Thrombosis and Haemostasis: JTH
Qi-Fang Huang, Zhen-Yu Zhang, Jan Van Keer, Sander Trenson, Esther Nkuipou-Kenfack, Wen-Yi Yang, Lutgarde Thijs, Johan Vanhaecke, Lucas N L Van Aelst, Johan Van Cleemput, Stefan Janssens, Peter Verhamme, Harald Mischak, Jan A Staessen
Background: Chronic kidney disease (CKD) is common in patients after heart transplantation (HTx). We assessed whether in HTx recipients the proteomic urinary classifier CKD273 or sequenced urinary peptides revealing the parental proteins correlated with the estimated glomerular filtration rate (eGFR). Methods: In 368 HTx patients, we measured the urinary peptidome and analysed CKD273 and 48 urinary peptides with a detectable signal in >95% of participants. After 9...
July 2, 2018: Nephrology, Dialysis, Transplantation
Annegret Ulke-Lemée, Arthur Lau, Michelle C Nelson, Matthew T James, Daniel A Muruve, Justin A MacDonald
Inflammation is an integral component of many diseases, including chronic kidney disease (CKD). ASC (apoptosis-associated speck-like protein containing CARD, also PYCARD) is the key inflammasome adaptor protein in the innate immune response. Since ASC specks, a macromolecular condensate of ASC protein, can be released by inflammasome-activated cells into the extracellular space to amplify inflammatory responses, the ASC protein could be an important biomarker in diagnostic applications. Herein, we describe the development and validation of a multiple reaction monitoring mass spectrometry (MRM-MS) assay for the accurate quantification of ASC in human biospecimens...
August 2018: Inflammation
Baihong Li, Yanqin Zhang, Fang Wang, Viji Nair, Fangrui Ding, Huijie Xiao, Yong Yao, Matthias Kretzler, Wenjun Ju, Jie Ding
BACKGROUND: Alport syndrome is a rare hereditary kidney disease manifested with progressive renal failure. Considerable variation exists in terms of disease progression among patients with Alport syndrome. Identification of patients at high risk of rapid progression remains an unmet need. Urinary epidermal growth factor (uEGF) has been shown to be independently associated with risk of progression to adverse kidney outcome in multiple independent adult chronic kidney disease (CKD) cohorts...
June 11, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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