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https://www.readbyqxmd.com/read/28079125/establishment-of-a-integrative-multi-omics-expression-database-ckddb-in-the-context-of-chronic-kidney-disease-ckd
#1
Marco Fernandes, Holger Husi
Complex human traits such as chronic kidney disease (CKD) are a major health and financial burden in modern societies. Currently, the description of the CKD onset and progression at the molecular level is still not fully understood. Meanwhile, the prolific use of high-throughput omic technologies in disease biomarker discovery studies yielded a vast amount of disjointed data that cannot be easily collated. Therefore, we aimed to develop a molecule-centric database featuring CKD-related experiments from available literature publications...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077457/systems-biology-derived-biomarkers-to-predict-progression-of-renal-function-decline-in-type-2-diabetes-mellitus
#2
Gert Mayer, Hiddo J L Heerspink, Constantin Aschauer, Andreas Heinzel, Georg Heinze, Alexander Kainz, Judith Sunzenauer, Paul Perco, Dick de Zeeuw, Peter Rossing, Michelle Pena, Rainer Oberbauer
OBJECTIVE: Chronic kidney disease (CKD) in diabetes has a complex molecular and likely multifaceted pathophysiology. We aimed to validate a panel of biomarkers identified using a systems biology approach to predict the individual decline of estimated glomerular filtration rate (eGFR) in a large group of patients with type 2 diabetes mellitus and CKD at various stages. RESEARCH DESIGN AND METHODS: We used publicly available "omics" data to develop a molecular process model of CKD in diabetes and identified a representative parsimonious set of nine molecular biomarkers: chitinase 3-like protein 1, growth hormone 1, hepatocyte growth factor, matrix metalloproteinase (MMP) 2, MMP7, MMP8, MMP13, tyrosine kinase, and tumor necrosis factor receptor-1...
January 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28075321/effects-of-exercise-and-lifestyle-intervention-on-oxidative-stress-in-chronic-kidney-disease
#3
David M Small, Kassia S Beetham, Erin J Howden, David R Briskey, David W Johnson, Nicole M Isbel, Glenda C Gobe, Jeff S Coombes
OBJECTIVES: Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients. METHODS: A total of 136 stage 3-4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months...
January 11, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28062677/filtration-markers-as-predictors-of-esrd-and-mortality-individual-participant-data-meta-analysis
#4
Lesley A Inker, Josef Coresh, Yingying Sang, Chi-Yuan Hsu, Meredith C Foster, John H Eckfeldt, Amy B Karger, Robert G Nelson, Xun Liu, Mark Sarnak, Lawrence J Appel, Morgan Grams, Dawei Xie, Paul L Kimmel, Harold Feldman, Vasan Ramachandran, Andrew S Levey
BACKGROUND AND OBJECTIVES: Serum β-trace protein (BTP) and β-2 microglobulin (B2M) are associated with risk of ESRD and death in the general population and in populations at high risk for these outcomes (GP/HR) and those with CKD, but results differ among studies. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed an individual patient-level meta-analysis including three GP/HR studies (n=17,903 participants) and three CKD studies (n=5415). We compared associations, risk prediction, and improvement in reclassification of eGFR using BTP (eGFRBTP) and B2M (eGFRB2M) alone and the average (eGFRavg) of eGFRBTP, eGFRB2M, creatinine (eGFRcr), and cystatin C (eGFRcys), to eGFRcr, eGFRcys, and their combination (eGFRcr-cys) for ESRD (2075 events) and death (7275 events)...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28062676/associations-of-conventional-echocardiographic-measures-with-incident-heart-failure-and-mortality-the-chronic-renal-insufficiency-cohort
#5
Ruth F Dubin, Rajat Deo, Nisha Bansal, Amanda H Anderson, Peter Yang, Alan S Go, Martin Keane, Ray Townsend, Anna Porter, Matthew Budoff, Shaista Malik, Jiang He, Mahboob Rahman, Jackson Wright, Thomas Cappola, Radhakrishna Kallem, Jason Roy, Daohang Sha, Michael G Shlipak
BACKGROUND AND OBJECTIVES: Heart failure is the most frequent cardiac complication of CKD. Left ventricular hypertrophy is common and develops early in CKD, but studies have not adequately evaluated the association of left ventricular mass index with heart failure incidence among men and women with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We evaluated echocardiograms of 2567 participants without self-reported heart failure enrolled in the Chronic Renal Insufficiency Cohort Study...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28062569/inhibition-of-%C3%AE-v%C3%AE-5-integrin-attenuates-vascular-permeability-and-protects-against-renal-ischemia-reperfusion-injury
#6
Amy McCurley, Stella Alimperti, Silvia B Campos-Bilderback, Ruben M Sandoval, Jenna E Calvino, Taylor L Reynolds, Catherine Quigley, Joshua W Mugford, William J Polacheck, Ivan G Gomez, Jennifer Dovey, Graham Marsh, Angela Huang, Fang Qian, Paul H Weinreb, Brian M Dolinski, Shaun Moore, Jeremy S Duffield, Christopher S Chen, Bruce A Molitoris, Shelia M Violette, Michael A Crackower
Ischemia-reperfusion injury (IRI) is a leading cause of AKI. This common clinical complication lacks effective therapies and can lead to the development of CKD. The αvβ5 integrin may have an important role in acute injury, including septic shock and acute lung injury. To examine its function in AKI, we utilized a specific function-blocking antibody to inhibit αvβ5 in a rat model of renal IRI. Pretreatment with this anti-αvβ5 antibody significantly reduced serum creatinine levels, diminished renal damage detected by histopathologic evaluation, and decreased levels of injury biomarkers...
January 6, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28054933/association-of-hiv-infection-with-biomarkers-of-kidney-injury-and-fibrosis-in-the-multicenter-aids-cohort-study
#7
Vasantha Jotwani, Rebecca Scherzer, Michelle M Estrella, Lisa P Jacobson, Mallory D Witt, Frank Palella, Ken Ho, Michael Bennett, Chirag R Parikh, Joachim H Ix, Michael Shlipak
BACKGROUND: Chronic kidney disease (CKD) is common among HIV-infected individuals, but serum creatinine is insensitive for detecting kidney damage at early stages. We hypothesized that HIV infection would be associated with elevations in subclinical markers of kidney injury and fibrosis in a contemporary cohort of men. METHODS: In this cross-sectional study, we measured urine levels of interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), pro-collagen type III N-terminal pro-peptide (PIIINP), and albumin-creatinine ratio (ACR) in 813 HIV-infected and 331 uninfected men enrolled in the Multicenter AIDS Cohort Study...
January 5, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28052631/why-and-how-to-measure-renal-function-in-patients-with-liver-disease
#8
REVIEW
Salvatore Piano, Antonietta Romano, Marco Di Pascoli, Paolo Angeli
Patients with advanced liver disease frequently have impaired renal function. Both acute kidney injury (AKI) and chronic kidney disease (CKD) are quite common in patients with cirrhosis and both are associated with a worse prognosis in these patients. A careful assessment of renal function is highly important in these patients to help physicians determine their diagnosis, prognosis and therapeutic management and to define transplantation strategies (liver transplantation alone vs simultaneous liver and kidney transplantation)...
January 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28045061/feature-selection-and-classification-of-urinary-mrna-microarray-data-by-iterative-random-forest-to-diagnose-renal-fibrosis-a-two-stage-study
#9
Le-Ting Zhou, Yu-Han Cao, Lin-Li Lv, Kun-Ling Ma, Ping-Sheng Chen, Hai-Feng Ni, Xiang-Dong Lei, Bi-Cheng Liu
Renal fibrosis is a common pathological pathway of progressive chronic kidney disease (CKD). However, kidney function parameters are suboptimal for detecting early fibrosis, and therefore, novel biomarkers are urgently needed. We designed a 2-stage study and constructed a targeted microarray to detect urinary mRNAs of CKD patients with renal biopsy and healthy participants. We analysed the microarray data by an iterative random forest method to select candidate biomarkers and produce a more accurate classifier of renal fibrosis...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28029431/urine-biomarkers-of-tubular-injury-do-not-improve-on-the-clinical-model-predicting-chronic-kidney-disease-progression
#10
Chi-Yuan Hsu, Dawei Xie, Sushrut S Waikar, Joseph V Bonventre, Xiaoming Zhang, Venkata Sabbisetti, Theodore E Mifflin, Josef Coresh, Clarissa J Diamantidis, Jiang He, Claudia M Lora, Edgar R Miller, Robert G Nelson, Akinlolu O Ojo, Mahboob Rahman, Jeffrey R Schelling, Francis P Wilson, Paul L Kimmel, Harold I Feldman, Ramachandran S Vasan, Kathleen D Liu
Few investigations have evaluated the incremental usefulness of tubular injury biomarkers for improved prediction of chronic kidney disease (CKD) progression. As such, we measured urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, N-acetyl-ß-D-glucosaminidase and liver fatty acid binding protein under highly standardized conditions among 2466 enrollees of the prospective Chronic Renal Insufficiency Cohort Study. During 9433 person-years of follow-up, there were 581 cases of CKD progression defined as incident end-stage renal disease or halving of the estimated glomerular filtration rate...
October 28, 2016: Kidney International
https://www.readbyqxmd.com/read/28028134/fibroblast-growth-factor-23-levels-associate-with-aki-and-death-in-critical-illness
#11
David E Leaf, Kirolos A Jacob, Anand Srivastava, Margaret E Chen, Marta Christov, Harald Jüppner, Venkata S Sabbisetti, Aline Martin, Myles Wolf, Sushrut S Waikar
Elevated plasma levels of the osteocyte-derived hormone fibroblast growth factor 23 (FGF23) have emerged as a powerful biomarker of cardiovascular disease and death in patients with CKD. Whether elevated urinary or plasma FGF23 levels are prospectively associated with AKI and death in critically ill patients is unknown. We therefore conducted a prospective cohort study of 350 critically ill patients admitted to intensive care units at an academic medical center to investigate whether higher urinary FGF23 levels associate with the composite end point of AKI or in-hospital mortality (AKI/death)...
December 27, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28019047/neutrophil-gelatinase-associated-lipocalin-in-cats-with-naturally-occurring-chronic-kidney-disease
#12
I-C Wang, W-L Hsu, P-H Wu, H-Y Yin, H-J Tsai, Y-J Lee
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for the early prediction of renal damage and the progression of chronic kidney disease (CKD) in humans and dogs. HYPOTHESIS: Neutrophil gelatinase-associated lipocalin also may play a role in the progression of CKD in cats. ANIMALS: Eighty CKD and 18 control cats. METHODS: Cats were categorized into different stages according to the International Renal Interest Society (IRIS) staging system...
December 25, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28017524/active-vitamin-d-treatment-in-ckd-patients-raises-serum-sclerostin-and-this-effect-is-modified-by-circulating-pentosidine-levels
#13
C Torino, P Pizzini, S Cutrupi, G Tripepi, F Mallamaci, R Thadhani, C Zoccali
BACKGROUND AND AIMS: 1,25(OH)2Vitamin D increases the expression of the sclerostin gene. Whether vitamin D receptor activation (VDRA) influences serum sclerostin in CKD and whether compounds interfering with VDRA like Advanced Glycosylation End Products (AGEs) may alter the sclerostin response to VDRA is unknown. METHODS AND RESULTS: Eighty-eight stage G3-4 CKD patients randomly received 2 μg paricalcitol (PCT)/day (n = 44) or placebo (n = 44) for 12 weeks...
November 23, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28017325/inflammation-and-elevated-levels-of-fibroblast-growth-factor-23-are-independent-risk-factors-for%C3%A2-death-in-chronic-kidney-disease
#14
Jair Munoz Mendoza, Tamara Isakova, Xuan Cai, Liz Y Bayes, Christian Faul, Julia J Scialla, James P Lash, Jing Chen, Jiang He, Sankar Navaneethan, Lavinia Negrea, Sylvia E Rosas, Matthias Kretzler, Lisa Nessel, Dawei Xie, Amanda Hyre Anderson, Dominic S Raj, Myles Wolf
Inflammation is a consequence of chronic kidney disease (CKD) and is associated with adverse outcomes in many clinical settings. Inflammation stimulates production of fibroblast growth factor 23 (FGF23), high levels of which are independently associated with mortality in CKD. Few large-scale prospective studies have examined inflammation and mortality in patients with CKD, and none tested the interrelationships among inflammation, FGF23, and risk of death. Therefore, we conducted a prospective investigation of 3875 participants in the Chronic Renal Insufficiency Cohort (CRIC) study with CKD stages 2 to 4 to test the associations of baseline plasma interleukin-6, high-sensitivity C-reactive protein, and FGF23 levels with all-cause mortality, censoring at the onset of end-stage renal disease...
December 22, 2016: Kidney International
https://www.readbyqxmd.com/read/28013471/inflammation-and-oxidation-do-they-improve-after-kidney-transplantation-relationship-with-mortality-after-transplantation
#15
Laura Cañas, Eva Iglesias, María Cruz Pastor, Jaume Barallat, Javier Juega, Ioana Bancu, Ricardo Lauzurica
: Patients with chronic kidney disease (CKD) are characterized by a state of inflammation and oxidative stress that seems to improve after kidney transplantation (KT). Nevertheless, there is controversy regarding what is the best marker that better define inflammation and specially oxidative stress. OBJECTIVE: To evaluate the biomarkers which are associated with improvements in inflammation and lipid peroxidation in patients who have undergone KT. To evaluate the relationship between inflammation, lipid peroxidation and mortality in KT...
December 24, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/28011387/the-kidney-and-periodontal-disease-kapd-study-a-pilot-randomized-controlled-trial-testing-the-effect-of-non-surgical-periodontal-therapy-on-chronic-kidney-disease
#16
Vanessa Grubbs, Faviola Garcia, Bonnie L Jue, Eric Vittinghoff, Mark Ryder, David Lovett, Jacqueline Carrillo, Steven Offenbacher, Peter Ganz, Kirsten Bibbins-Domingo, Neil R Powe
INTRODUCTION: Chronic kidney disease (CKD) remains a prevalent public health problem that disproportionately affects minorities and the poor, despite intense efforts targeting traditional risk factors. Periodontal diseases are common bacterial plaque-induced inflammatory conditions that can respond to treatment and have been implicated as a CKD risk factor. However there is limited evidence that treatment of periodontal disease slows the progression of CKD. METHODS/DESIGN: We describe the protocol of the Kidney and Periodontal Disease (KAPD) study, a 12-month un-blinded, randomized, controlled pilot trial with two intent-to-treat treatment arms: 1...
December 20, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28011101/cartilage-mri-t2-%C3%A2-relaxation-time-and-perfusion-changes-of-the-knee-in-a-5-6-nephrectomy-rat-model-of-chronic-kidney-disease
#17
C-Y Wang, Y-J Peng, Y-J Hsu, H-S Lee, Y-C Chang, C-S Chang, S-W Chiang, Y-C Hsu, M-H Lin, G-S Huang
OBJECTIVE: Chronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2(∗) relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2(∗) as imaging biomarkers to monitor disease progression...
December 21, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28003041/the-impact-of-oat-avena-sativa-consumption-on-biomarkers-of-renal-function-in-patients-with-chronic-kidney-disease-a-parallel-randomized-clinical-trial
#18
Mohammad Hossein Rouhani, Mojgan Mortazavi Najafabadi, Pamela J Surkan, Ahmad Esmaillzadeh, Awat Feizi, Leila Azadbakht
BACKGROUND & OBJECTIVE: Animal studies report that oat (Avena sativa L) intake has favorable effects on kidney function. However, the effects of oat consumption have not been assessed in humans. The aim of this study was to examine the impact of oat intake on biomarkers of renal function in patients with chronic kidney disease (CKD). METHODS: Fifty-two patients with CKD were randomly assigned to a control group (recommended to reduce intake of dietary protein, phosphorus, sodium and potassium) or an oat consumption group (given nutritional recommendations for controls +50 g/day oats)...
December 2, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27992360/chronic-kidney-disease-induces-inflammatory-cd40-monocyte-differentiation-via-homocysteine-elevation-and-dna-hypomethylation
#19
Jiyeon Yang, Pu Fang, Daohai Yu, Lixiao Zhang, Daqing Zhang, Xiaohua Jiang, William Y Yang, Teodoro Bottiglieri, Satya P Kunapuli, Jun Yu, Eric T Choi, Yong Ji, Xiaofeng Yang, Hong Wang
RATIONALE: Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia and have a higher cardiovascular mortality than those without hyperhomocysteinemia by 10-fold. OBJECTIVE: We investigated monocyte differentiation in human CKD and cardiovascular disease (CVD). METHODS AND RESULTS: We identified CD40 as a CKD-related monocyte activation gene using CKD-monocyte -mRNA array analysis and classified CD40 monocyte (CD40(+)CD14(+)) as a stronger inflammatory subset than the intermediate monocyte (CD14(++)CD16(+)) subset...
November 11, 2016: Circulation Research
https://www.readbyqxmd.com/read/27990481/increased-telomere-attrition-after-renal-transplantation-impact-of-antimetabolite-therapy
#20
Karin Luttropp, Louise Nordfors, Dagmara McGuinness, Lars Wennberg, Hannah Curley, Tara Quasim, Helena Genberg, John Sandberg, Isabella Sönnerborg, Martin Schalling, Abdul Rashid Qureshi, Peter Bárány, Paul G Shiels, Peter Stenvinkel
BACKGROUND: The uremic milieu exposes chronic kidney disease (CKD) patients to premature ageing processes. The impact of renal replacement therapy (dialysis and renal transplantation [RTx]) or immunosuppressive treatment regimens on ageing biomarkers has scarcely been studied. METHODS: In this study telomere length in whole blood cells was measured in 49 dialysis patients and 47 RTx patients close to therapy initiation and again after 12 months. Forty-three non-CKD patients were included as controls...
December 2016: Transplantation Direct
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