keyword
MENU ▼
Read by QxMD icon Read
search

Environmental enteric dysfunction

keyword
https://www.readbyqxmd.com/read/28157786/campylobacter-jejuni-and-associated-immune-mechanisms-short-term-effects-and-long-term-implications-for-infants-in-low-income-countries
#1
Amanda E Schnee, William A Petri
PURPOSE OF REVIEW: Campylobacter jejuni is recognized as one of the most common causes of food-borne gastrointestinal illness worldwide, resulting in a self-limiting dysentery in developed countries. However, it is increasingly gaining attention due to its association with postinfectious complications such as Guillain-Barré Syndrome and recently recognized importance in early childhood diarrhea in developing countries. We hypothesize that the inflammation mediated by C. jejuni infection causes environmental enteric dysfunction, and with contribution from diet and the host, microbiome may be responsible for growth faltering in children and developmental disability...
February 2, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28122695/environmental-enteric-dysfunction-is-associated-with-carnitine-deficiency-and-altered-fatty-acid-oxidation
#2
Richard D Semba, Indi Trehan, Ximin Li, Ruin Moaddel, M Isabel Ordiz, Kenneth M Maleta, Klaus Kraemer, Michelle Shardell, Luigi Ferrucci, Mark Manary
BACKGROUND: Environmental enteric dysfunction (EED), a condition characterized by small intestine inflammation and abnormal gut permeability, is widespread in children in developing countries and a major cause of growth failure. The pathophysiology of EED remains poorly understood. METHODS: We measured serum metabolites using liquid chromatography-tandem mass spectrometry in 400 children, aged 12-59months, from rural Malawi. Gut permeability was assessed by the dual-sugar absorption test...
January 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28112064/nutrition-infection-and-stunting-the-roles-of-deficiencies-of-individual-nutrients-and-foods-and-of-inflammation-as-determinants-of-reduced-linear-growth-of-children
#3
D Joe Millward
The regulation of linear growth by nutritional and inflammatory influences is examined in terms of growth-plate endochondral ossification, in order to better understand stunted growth in children. Linear growth is controlled by complex genetic, physiological, and nutrient-sensitive endocrine/paracrine/autocrine mediated molecular signalling mechanisms, possibly including sleep adequacy through its influence on growth hormone secretion. Inflammation, which accompanies most infections and environmental enteric dysfunction, inhibits endochondral ossification through the action of mediators including proinflammatory cytokines, the activin A-follistatin system, glucocorticoids and fibroblast growth factor 21 (FGF21)...
January 23, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28100604/sufficient-protein-quality-of-food-aid-varies-with-the-physiologic-status-of-recipients
#4
Meghan Callaghan, Momo Oyama, Mark Manary
Protein quality scores use the amino acid (AA) requirements of a healthy North American child. AA requirements vary with physiologic status. We estimated AA requirements for healthy North American children, children with environmental enteric dysfunction, children recovering from wasting, and children with an acute infection. The protein quality of food aid products was then calculated to determine whether it was sufficient in all these groups, and we found that it may not be adequate for all of them. Physiologic status is important when assessing the protein quality of food aid...
January 18, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/27956653/environmental-enteric-dysfunction-and-the-fecal-microbiota-in-malawian-children
#5
M Isabel Ordiz, Kevin Stephenson, Sophia Agapova, Kristine M Wylie, Ken Maleta, John Martin, Indi Trehan, Phillip I Tarr, Mark J Manary
Environmental enteric dysfunction (EED) is often measured with a dual sugar absorption test and implicated as a causative factor in childhood stunting. Disturbances in the gut microbiota are hypothesized to be a mechanism by which EED is exacerbated, although this supposition lacks support. We performed 16S ribosomal RNA gene sequencing of fecal samples from 81 rural Malawian children with varying degrees of EED to determine which bacterial taxa were associated with EED. At the phyla level, Proteobacteria abundance is reduced with severe EED...
February 8, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27940670/environmental-enteric-dysfunction-and-growth-failure-stunting-in-global-child-health
#6
REVIEW
Victor Owino, Tahmeed Ahmed, Michael Freemark, Paul Kelly, Alexander Loy, Mark Manary, Cornelia Loechl
Approximately 25% of the world's children aged <5 years have stunted growth, which is associated with increased mortality, cognitive dysfunction, and loss of productivity. Reducing by 40% the number of stunted children is a global target for 2030. The pathogenesis of stunting is poorly understood. Prenatal and postnatal nutritional deficits and enteric and systemic infections clearly contribute, but recent findings implicate a central role for environmental enteric dysfunction (EED), a generalized disturbance of small intestinal structure and function found at a high prevalence in children living under unsanitary conditions...
December 2016: Pediatrics
https://www.readbyqxmd.com/read/27918230/mechanisms-of-cross-talk-between-the-diet-the-intestinal-microbiome-and-the-undernourished-host
#7
Helene Velly, Robert A Britton, Geoffrey A Preidis
Undernutrition remains one of the most pressing global health challenges today, contributing to nearly half of all deaths in children under five years of age. Although insufficient dietary intake and environmental enteric dysfunction are often inciting factors, evidence now suggests that unhealthy gut microbial populations perpetuate the vicious cycle of pathophysiology that results in persistent growth impairment in children. The metagenomics era has facilitated new research identifying an altered microbiome in undernourished hosts and has provided insight into a number of mechanisms by which these alterations may affect growth...
December 5, 2016: Gut Microbes
https://www.readbyqxmd.com/read/27867383/environmental-toxicants-induced-immune-responses-in-the-olfactory-mucosa
#8
REVIEW
Fumiaki Imamura, Sanae Hasegawa-Ishii
Olfactory sensory neurons (OSNs) are the receptor cells for the sense of smell. Although cell bodies are located in the olfactory mucosa (OM) of the nasal cavity, OSN axons directly project to the olfactory bulb (OB) that is a component of the central nervous system (CNS). Because of this direct and short connection from this peripheral tissue to the CNS, the olfactory system has attracted attention as a port-of-entry for environmental toxicants that may cause neurological dysfunction. Selected viruses can enter the OB via the OM and directly affect the CNS...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27807040/a-combined-intervention-of-zinc-multiple-micronutrients-and-albendazole-does-not-ameliorate-environmental-enteric-dysfunction-or-stunting-in-rural-malawian-children-in-a-double-blind-randomized-controlled-trial
#9
Alfred Z Wang, Robert J Shulman, Audrey H Crocker, Chrissie Thakwalakwa, Kenneth M Maleta, Sridevi Devaraj, Mark J Manary, Indi Trehan
BACKGROUND: Environmental enteric dysfunction (EED) and linear growth stunting affect many rural agrarian children in the developing world and contribute to the persistently high rates of stunting that are observed worldwide. Effective interventions to consistently ameliorate EED are lacking. OBJECTIVE: We tested whether a bundle of safe and affordable interventions would decrease EED and stunting over 12-24 wk in a cohort of rural Malawian children 12-35 mo old...
January 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/27733402/protein-and-zinc-deficient-diets-modulate-the-murine-microbiome-and-metabolic-phenotype
#10
Jordi Mayneris-Perxachs, David T Bolick, Joy Leng, Greg L Medlock, Glynis L Kolling, Jason A Papin, Jonathan R Swann, Richard L Guerrant
BACKGROUND: Environmental enteropathy, which is linked to undernutrition and chronic infections, affects the physical and mental growth of children in developing areas worldwide. Key to understanding how these factors combine to shape developmental outcomes is to first understand the effects of nutritional deficiencies on the mammalian system including the effect on the gut microbiota. OBJECTIVE: We dissected the nutritional components of environmental enteropathy by analyzing the specific metabolic and gut-microbiota changes that occur in weaned-mouse models of zinc or protein deficiency compared with well-nourished controls...
November 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27688656/gastrointestinal-disorders-associated-with-migraine-a-comprehensive-review
#11
REVIEW
Carlos R Cámara-Lemarroy, Rene Rodriguez-Gutierrez, Roberto Monreal-Robles, Alejandro Marfil-Rivera
Migraine is a recurrent and commonly disabling primary headache disorder that affects over 17% of women and 5%-8% of men. Migraine susceptibility is multifactorial with genetic, hormonal and environmental factors all playing an important role. The physiopathology of migraine is complex and still not fully understood. Many different neuropeptides, neurotransmitters and brain pathways have been implicated. In connection with the myriad mechanisms and pathways implicated in migraine, a variety of multisystemic comorbidities (e...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27634185/the-gut-microbiota-and-the-emergence-of-autoimmunity-relevance-to-major-psychiatric-disorders
#12
E G Severance, D Tveiten, L H Lindström, R H Yolken, K L Reichelt
BACKGROUND: Autoimmune phenotypes are prevalent in major psychiatric disorders. Disequilibria of cellular processes occurring in the gastrointestinal (GI) tract likely contribute to immune dysfunction in psychiatric disorders. As the venue of a complex community of resident microbes, the gut in a homeostatic state equates with a functional digestive system, cellular barrier stability and properly regulated recognition of self and non-self antigens. When gut processes become disrupted as a result of environmental or genetic factors, autoimmunity may ensue...
September 14, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27632432/stable-isotope-techniques-for-the-assessment-of-host-and-microbiota-response-during-gastrointestinal-dysfunction
#13
Ross N Butler, Margaret Kosek, Nancy F Krebs, Cornelia U Loechl, Alexander Loy, Victor O Owino, Michael B Zimmermann, Douglas J Morrison
The International Atomic Energy Agency convened a technical meeting on environmental enteric dysfunction (EED) in Vienna (October 28-30, 2015; https://nucleus.iaea.org/HHW/Nutrition/EED_Technical_Meeting/index.html) to bring together international experts in the fields of EED, nutrition, and stable isotope technologies. Advances in stable isotope-labeling techniques open up new possibilities to improve our understanding of gastrointestinal dysfunction and the role of the microbiota in host health. In the context of EED, little is known about the role gut dysfunction may play in macro- and micronutrient bioavailability and requirements and what the consequences may be for nutritional status and linear growth...
January 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27546205/risk-factors-for-malnutrition-and-environmental-enteric-dysfunction-you-really-are-what-you-eat
#14
Sana Syed, Christopher P Duggan
No abstract text is available yet for this article.
August 18, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27538949/nanowired-drug-delivery-across-the-blood-brain-barrier-in-cns-injury-and-repair
#15
Aruna Sharma, Preeti Menon, Dafin F Muresanu, Asya Ozkizilcik, Z Ryan Tian, José V Lafuente, Hari Sharma
The BBB is a physiological regulator of transport of essential items from blood to brain for the maintenance of homeostasis of the central nervous system (CNS) within the narrow limit. The BBB is also responsible for export of harmful or metabolic products from brain to blood to keep the fluid microenvironment of the CNS healthy. However, following any noxious insult to the brain caused by trauma, ischemia or environmental/chemical toxins the function of the BBB is altered to small as well as to large molecules e...
August 19, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27495791/environmental-enteropathy-elusive-but-significant-subclinical-abnormalities-in-developing-countries
#16
REVIEW
Koji Watanabe, William A Petri
Environmental enteropathy/Environmental enteric dysfunction (EE/EED) is a chronic disease of small intestine characterized by gut inflammation and barrier disruption, malabsorption and systemic inflammation in the absence of diarrhea. It is predominantly diseases of children in low income countries and is hypothesized to be caused by continuous exposure to fecally contaminated food, water and fomites. It had not been recognized as a priority health issue because it does not cause overt symptoms and was seen in apparently healthy individuals...
August 2016: EBioMedicine
https://www.readbyqxmd.com/read/27462071/limited-effects-of-preterm-birth-and-the-first-enteral-nutrition-on-cerebellum-morphology-and-gene-expression-in-piglets
#17
Anders Bergström, Sanne S Kaalund, Kerstin Skovgaard, Anders D Andersen, Bente Pakkenberg, Ann Rosenørn, Ruurd M van Elburg, Thomas Thymann, Gorm O Greisen, Per T Sanglid
Preterm pigs show many signs of immaturity that are characteristic of preterm infants. In preterm infants, the cerebellum grows particularly rapid and hypoplasia and cellular lesions are associated with motor dysfunction and cognitive deficits. We hypothesized that functional brain delays observed in preterm pigs would be paralleled by both structural and molecular differences in the cerebellum relative to term born piglets. Cerebella were collected from term (n = 56) and preterm (90% gestation, n = 112) pigs at 0, 5, and 26 days after birth for stereological volume estimations, large-scale qPCR gene expression analyses (selected neurodevelopmental genes) and western blot protein expression analysis (Sonic Hedgehog pathway)...
July 2016: Physiological Reports
https://www.readbyqxmd.com/read/27347722/environmental-enteric-dysfunction-is-associated-with-poor-linear-growth-and-can-be-identified-by-host-fecal-mrnas
#18
Maria Isabel Ordiz, Nurmohammad Shaikh, Indi Trehan, Ken Maleta, Jennifer Stauber, Robert Shulman, Sridevi Devaraj, Phillip I Tarr, Mark J Manary
OBJECTIVE: Environmental enteric dysfunction (EED) can be assessed by the lactulose:mannitol (L:M) test. Our objective was to determine if selected host fecal transcripts were correlated with EED, and whether transcripts and clinical characteristics could be used to predict EED in rural African children. METHODS: Demographic and sanitation characteristics, along with L:M testing and host fecal transcript analyses from 798 asymptomatic Malawian children aged 12 to 61 months were compared with linear growth over the subsequent 3 months...
November 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27322559/environmental-enteric-dysfunction-is-associated-with-altered-bile-acid-metabolism
#19
Richard D Semba, Marta Gonzalez-Freire, Ruin Moaddel, Indi Trehan, Kenneth M Maleta, Mohammed Khadeer, M Isabel Ordiz, Luigi Ferrucci, Mark J Manary
OBJECTIVES: Environmental enteric dysfunction (EED), a clinically asymptomatic condition characterized by inflammation of the small bowel mucosa, villous atrophy, and increased gut permeability, is common among children in developing countries. Because of abnormal gut mucosa and altered gut microbiome, EED could potentially affect the metabolism and enterohepatic circulation of bile acids. METHODS: In 313 children, aged 12-59 months, EED was assessed by the dual sugar absorption test...
June 17, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27294788/metabolic-alterations-in-children-with-environmental-enteric-dysfunction
#20
Richard D Semba, Michelle Shardell, Indi Trehan, Ruin Moaddel, Kenneth M Maleta, M Isabel Ordiz, Klaus Kraemer, Mohammed Khadeer, Luigi Ferrucci, Mark J Manary
Environmental enteric dysfunction, an asymptomatic condition characterized by inflammation of the small bowel mucosa, villous atrophy, malabsorption, and increased intestinal permeability, is a major contributor to childhood stunting in low-income countries. Here we report the relationship of increased intestinal permeability with serum metabolites in 315 children without acute malnutrition, aged 12-59 months, in rural Malawi. Increased gut permeability was associated with significant differences in circulating metabolites that included lower serum phosphatidylcholines, sphingomyelins, tryptophan, ornithine, and citrulline, and elevated serum glutamate, taurine, and serotonin...
2016: Scientific Reports
keyword
keyword
110003
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"