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Angela Spanu, Orazio Schillaci, Bastiana Piras, Diego F Calvisi, Antonio Falchi, Roberta Danieli, Susanna Nuvoli, Franca Dore, Giuseppe Madeddu
In a retrospective study performed in non-functioning GEP tumor patients we further investigated (111)In-Pentetreotide SPECT/CT usefulness in diagnosis, staging and follow-up also evaluating whether the procedure may give more information than conventional imaging procedures (CIP), such as CT, MRI, US. We enrolled 104 consecutive patients with non-functioning GEP tumors, 30 in initial diagnosis and staging phases (IDS) and 74 in follow-up (FU). All patients underwent somatostatin receptor scintigraphy (SRS) whole body scan at 4, 24 and, if necessary, 48 hours followed by abdominal and chest SPECT/CT after (111)In-Pentetreotide 148-222 MBq i...
2017: American Journal of Nuclear Medicine and Molecular Imaging
Carolina Carcano, Eduardo C Oliveira, Felipe Martinez, Jacobo Kirsch
A young patient with Crohn's disease is presented in whom pulmonary carcinoid tumor was incidentally found. Bronchoscopy showed an endobronchial lesion and biopsy pathology was consistent with atypical carcinoid. Octeotride scan suggested primary origin of the tumor. Although patients with Crohn's disease have been reported to have increased incidence of intestinal carcinoid, we believe this to be the second case of primary carcinoid pulmonary located in this population.
February 2013: Translational Lung Cancer Research
Jose María Monge Mirallas, Luis Alberto Asensio Lahoz, Francisco Ruiz Izquierdo, Jose Antonio Campos Sañudo, Fernando Martínez Bretones, Laura Martín Cuesta
OBJECTIVE: To report a case of large chylous ascytis as a late complication of a laparoscopic nephrectomy for renal tumor. METHODS: A 62 year old patient was admitted with general deterioration and abdominal distension due to chylous ascites. Abdominal ultrasound and CT led to the diagnosis. Paracentesis confirmed the presence of a large peritoneal chylous fluid effusion. RESULTS: The patient was treated by punction and placement of a percutaneous drainage...
July 2014: Archivos Españoles de Urología
Matias E Valsecchi, Misti Coronel, Charles M Intenzo, Sung M Kim, Agnieszka K Witkiewicz, Takami Sato
As uveal melanoma originates in the neural crest, we aimed to explore whether somatostatin receptor (SSTR) expression is present and plays any role in these patients. Heavily pretreated metastatic uveal melanoma patients were tested with somatostatin receptor scintigraphy (SRS). Planar images of the whole body complemented by single-photon emission computed tomography on suspected sites were acquired between 4 and 24 h after an intravenous administration of 185-222 MBq (5-6 mCi) of indium-octeotride. SSTR expression in metastatic tissues was confirmed by immunohistochemistry...
February 2013: Melanoma Research
Rute Maria Cerqueira, Luis Andrade, Manuel Rodriguez Correia, Carolina Duesca Fernandes, Maria Conceição Manso
INTRODUCTION: Oesophageal variceal bleeding (OVB) is a high mortality rate complication in patients with cirrhosis. The aim of this study was to assess the risk factors for in-hospital mortality (IHM) in cirrhotic patients with OVB. PATIENTS AND METHODS: The study cohort included 102 patients (average age, 55.4 ± 12.6 years, 71.6% men) consecutively admitted to our hospital with OVB. All the patients underwent upper endoscopy within 12 h and octeotride or terlipressin therapy was started at admission and continued for 5 days...
May 2012: European Journal of Gastroenterology & Hepatology
Alberto Fernandez, Olga Tabuenca, Angeles Peteiro
We present a case report of a patient with a suspicious ileal carcinoid tumour. Clinical examination as well as computer tomography (CT) scan suggested a tumour. Octeotride scan showed uptake in the same bowel loop reported as pathological in CT. The patient underwent surgery and biopsy which reported Crohn's disease (CD). The interest in the case is due to the fact that this is, to the best of our knowledge, the second report of Crohn's disease as a cause of false positive octeotride scan. Unfortunately, no somatostatin receptors could be found in the sample, so further studies should be performed...
September 14, 2008: World Journal of Gastroenterology: WJG
A B te Pas, K vd Ven, M P M Stokkel, F J Walther
UNLABELLED: A male newborn presented with congenital chylous ascites, the treatment of which is difficult and complicated due to persistent loss of chyle. The primary therapeutic goal is to reduce the lymph flow and to allow the leakage to heal naturally. Usually, conservative management--enteric rest with total parental feeding or an enteral diet with medium-chain triglycerides--can achieve this. A new treatment option is the use of octeotride, a somatostatin analogue. Both therapies failed in our patient, and surgical ligation of the leaking lymphatic duct was successful...
October 2004: Acta Paediatrica
Carlos Carvajal, Verónica Azabache, Pedro Lobos, Alvaro Ibarra
Glucagonomas are alpha pancreatic islet cell tumors that, when they are active, produce a syndrome characterized by necrolytic migratory erythema, diabetes mellitus, weight loss, anemia, glossitis, thromboembolism, neuropsychiatric disturbances and hyperglucagonemia. We report a 43 years old male presenting with a five years history of dermatological lesions, associated with weight loss, glossitis and onicodystrophy. Serum glucagon was 2200 pg/ml and a CAT scan showed a tumor in the tail of the pancreas. The tumor was surgically excised but one year later, hepatic metastases were found...
June 2002: Revista Médica de Chile
R D Schlegel, O Tiscornia, E de Vedia y Mitre, A R Lembeye, R Coqui, D Macagno, T Cravino, H Waisman
INTRODUCTION: The process of pancreatic regeneration, well known and accepted, is less known than the hepatic and includes different mechanisms and factors. Pancreatic regeneration is better known in acute pancreatitis. After an extensive pancreatic necrosis, the morphological and functional regeneration is assessed by dynamic computed tomography associated with normalization of glycemia and the exocrine function. Different groups identified and evaluated experimentally and clinically the actions of multiple factors involved in the process of pancreatic regeneration...
2000: Acta Gastroenterologica Latinoamericana
M Sasson, P Shvartzman
Malignant bowel obstruction occurs in about 10% of those with advanced abdominal cancer and in about 25% of those with advanced pelvic cancer. Such patients usually develop nausea, vomiting, constipation, abdominal dilatation and colicky pain. Traditional therapy consists of intravenous fluids and decompression by duodenal tube, gastrostomy or operation but postoperative mortality is high. Treatment requires hospitalization and therefore such patients have not been considered candidates for home care. Palliative medical techniques can cope with this syndrome and allow home care...
May 15, 1998: Harefuah
P Del Rio, G L Borgia, R Lampugnani
The finding of Merkel cell carcinoma is a rare but important event owing to the highly aggressive nature of this neoplasm. The authors report three cases of Merkel cell carcinoma with different onsets which were representative of the possible range of clinical symptoms and the prognosis of this pathology. In two cases diagnosis was made by chance, but in the third case a preoperative biopsy was initially performed with subsequent radicalization. The authors examine the diagnostic and therapeutic protocols proposed by other authors and compare them to their personal experience to ensure early diagnosis and radical therapy...
March 1999: Minerva Chirurgica
V Rufini, M Salvatori, I Saletnich, V Valenza, M L Maussier, G Martino, S M Corsello, M Pantusa, A Casolo, L Troncone
The aim of this study was to evaluate the effectiveness of a recently developed radiolabelled somatostatin analog (111In-pentetreotide) for the detection and localization of both medullary thyroid carcinoma (MTC) and carcinoid tumors, and to compare the results obtained with the results of 99mTc(V)-DMSA, and radioiodinated MIBG imaging. 111In-pentetreotide scintigraphy was performed in 9 patients with MTC and in 9 patients with carcinoid tumor. Whole body and SPECT studies were performed at 4 and 24 hours post-injection...
December 1995: Quarterly Journal of Nuclear Medicine
M N Tumiati, E Facchi, C Gatti, A Bossi, V Longari
The aim of this study was to identify the specific somatostatin receptors expressed by several tumors, utilizing 111In-octreotide, a long acting somatostatin analogue. We studied two different groups of patients: the first group was composed of 21 patients suffering from different pituitary adenomas, while the second group consisted of 12 patients affected by several different neoplasms. In vivo scintigraphy showed pentetreotide receptors only in large GH-secreting adenomas and several macroadenomas. Concerning the endocrine activity of the adenomas, 111In-octreotide showed a good sensibility in detecting GH-secreting tumors...
December 1995: Quarterly Journal of Nuclear Medicine
O M Laudanno, O A Bedini, J A Cesolari, P San Miguel
OBJECTIVE: To verify wether a cytoprotective or a antisecretant drug is effective on stress acute gastric. METHOD: Female Wistar rats (n=7), 200 g, 24 h fasted, water ad lib. were used. Experiment I. Stress (s) by immobilization and immersion in 181/3 C water, 6 h (control). 30 min pretreatment with 2 ml 800 mg/Kg in OG bolus Sucralfate. 800 mg/Kg OG Magaldrate. 800 mg/Kg OG AIMgOH. 800 mg/Kg OH Hydrotalcite. 100 aeg/Kg OG Misoprostol (antisecretant). 125 mg/Kg s...
1995: Acta Gastroenterologica Latinoamericana
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