Helena Mateos, Antonia Mallardi, Michele Camero, Gianvito Lanave, Cristiana Catella, Alessio Buonavoglia, Osvalda De Giglio, Canio Buonavoglia, Gerardo Palazzo
HYPOTHESIS: Surfactants are inexpensive chemicals with promising applications in virus inactivation, particularly for enveloped viruses. Yet, the detailed mechanisms by which surfactants deactivate coronaviruses remain underexplored. This study delves into the virucidal mechanisms of various surfactants on Feline Coronavirus (FCoV) and their potential applications against more pathogenic coronaviruses. EXPERIMENTS: By integrating virucidal activity assays with fluorescence spectroscopy, dynamic light scattering and laser Doppler electrophoresis, alongside liposome permeability experiments, we have analyzed the effects of non-ionic and ionic surfactants on viral activity...
February 12, 2024: Journal of Colloid and Interface Science