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non tuberculous mycobacteria

H Suzuki, Y Matsuda, M Noda, H Oishi, T Watanabe, T Sado, M Yamada, T Tamada, Y Okada
BACKGROUND AND OBJECTIVES: To treat organ transplant patients with mycobacterial infection, physicians need to pay attention to interaction between drugs used against mycobacteria and immunosuppressants. The purpose of this report is to describe the clinical features of and treatment for mycobacterial infection in lung transplant (LTx) recipients. METHODS: To investigate the incidence, treatment, and outcome for mycobacterial infection, we retrospectively reviewed 100 LTx recipients in our program since 2000...
November 2018: Transplantation Proceedings
S Cadmus, V Akinseye, A Adegbulu, N Ovwighose, M Ayoola, J Ogugua, H Adesokan, E Cadmus
Introduction: Tuberculosis (TB) remains a public health problem in sub-Saharan Africa coupled with dearth of information about the disease among livestock workers at risk of infection. We determined the prevalence of pulmonary TB infection and factors associated with its occurrence among livestock workers in south-western Nigeria. Methods: A cross-sectional study was conducted using active case-finding among livestock workers with sub-clinical pulmonary TB between August 2014 and March 2015...
September 2018: Journal of Preventive Medicine and Hygiene
J Saussereau, G Reboux, G Sfeir, J-C Dalphin
INTRODUCTION: Hot tub lung is a hypersensitivity pneumonitis (HP) due to exposure to inhaled non-tuberculous mycobacteria, the most frequent being Mycobacterium avium complex (MAC). CASE REPORT: A French couple developed typicalHP in the context of a repeated use of hot tubs. The husband had a severe hypoxemic form whereas his wife had a micronodular form with patchy ground glass on the thoracic scan, with less severe functional impairment. MAC was recovered in the hot tub water, but not in broncho-alveolar lavage fluid, and serologies were negative...
November 2, 2018: Revue des Maladies Respiratoires
C N'Dira Sanoussi, Bouke C de Jong, Mathieu Odoun, Karamatou Arekpa, Moulikatou Ali Ligali, Ousman Bodi, Simon Harris, Boatema Ofori-Anyinam, Dorothy Yeboah-Manu, Isaac Darko Otchere, Adwoa Asante-Poku, Severin Anagonou, Sebastien Gagneux, Mireia Coscolla, Leen Rigouts, Dissou Affolabi
PURPOSE: Differentiation of the Mycobacterium tuberculosis complex (MTBc) from non-tuberculous mycobacteria (NTM) is important for tuberculosis diagnosis and is a prerequisite for reliable phenotypic drug-resistance testing. We evaluated the performance of the rapid MPT64 antigen identification test for the detection of Mycobacterium africanum lineage 5 (MAF L5). METHODOLOGY: Smear-positive tuberculosis patients' sputa were included prospectively. Culture was performed on Löwenstein-Jensen medium and, when positive, the MPT64 test and the classical para-nitro benzoic acid susceptibility and heat-labile catalase (PNB/catalase) identification tests were performed...
November 2, 2018: Journal of Medical Microbiology
Rohit Prasad Yadav, Bashudev Baskota, Rabin Ratna Ranjitkar, Sandesh Dahal
INTRODUCTION: Non-tuberculous Mycobacteria are increasingly recognized, nowadays as an important pathogen in delayed surgical site infection in post operative cases. We here in describe cases of surgical site infection caused by Non-tuberculous Mycobacteria, seen in two centers in Jhapa. The aim of the study was to increase awareness of this atypical mycobacterial infection, prompt diagnosis, and treatment that may ultimately provide better care to patients. METHODS: Forty four patients underwent different kinds of operations in two different private hospitals in Jhapa district of Nepal...
March 2018: JNMA; Journal of the Nepal Medical Association
Wen-Cheng Chao, Ching-Heng Lin, Yi-Ming Chen, Chiann-Yi Hsu, Jun-Peng Chen, Hsin-Hua Chen
This study aimed to address the association between the usage of antibiotics to treat nontuberculous mycobacteria (NTM) infection and the risk of Sjögren's syndrome (SS). We identified 5,553 patients with newly diagnosed SS between 2002 and 2013 using Taiwan's National Health Insurance Research Database and compared them with 83,295 non-SS controls matched (1:15) for age, sex, and the year of their first SS diagnosis. An increased risk of SS was found in patients receiving new macrolides (adjusted odds ratios (aOR) 1...
October 30, 2018: Scientific Reports
R Martín Alelú, C Rico Espiñeira, M E Marti Carrera, M D Delgado Muñoz, A Gómez Fraile
AIM OF STUDY: To describe our experience in the management of non-tuberculosis mycobacterial lymphadenitits (NTML). METHODS: Retrospective analysis of patients who underwent surgery for NTML in our centre during the period between 2010-2017. Demographic data, diagnostic tests, treatment and follow up information were recovered from medical records. RESULTS: 65 patients (26 male/39 female) with a mean age of 31 months (range 7 months-12 years) were intervened during the period of study...
October 17, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Fériel Bouzid, Djaltou Aboubaker Osman, Emeline Baptiste, Jeremy Delerce, Mohamed Osman Hassan, Warsama Ibrahim Arreh, Anthony Levasseur, Eric Garnotel, Michel Drancourt
In low-income countries of the Horn of Africa, pulmonary infections are usually considered as tuberculosis, which diagnosis relies on clinical data and positive microscopic observation. This strategy allows non-tuberculous mycobacteria to escape detection, facilitating their emergence in populations. A non-tuberculous mycobacterium strain FB-527 was unexpectedly cultured from the sputum of a Djiboutian patient otherwise diagnosed with multi-drug resistant (MDR) tuberculosis. The sequencing of the rpoB and 16S rRNA genes showed that the isolate was identical to strain FI-09026 previously named "Mycobacterium simulans" and reported only once from a Somali patient...
October 26, 2018: Scientific Reports
Rajeev X Soman, Neha Gupta, Piyush Chaudhari, Ayesha Sunavala, Anjali Shetty, Camilla Rodrigues
Background: The profile of Infective endocarditis (IE) has been evolving continuously. Like other infectious Diseases (ID) syndromes, IE has not escaped from antibiotic resistance issues. The aim of this study was to determine the implications for diagnosis and treatment by studying the clinical profile and outcome of patients admitted with IE in a tertiary care centre in Mumbai during the period from 2007-2015.. Methods: 53 patients having definite or possible IE as per Modified Duke's Criteria (MDC), that were referred to the ID division, were included in this study...
April 2018: Journal of the Association of Physicians of India
Pradeep K Rai, Sathi Babu Chodisetti, Sudeep K Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K Janmeja, David C Jackson, Javed N Agrewala
BACKGROUND: The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobacterium tuberculosis (Mtb) infection interferes in the antigen processing and presentation of BCG in inducing protective immunity against Mtb. Thereby, indicating that any vaccine that require extensive antigen processing may not be efficacious in TB-endemic zones. Recently, we have demonstrated that the vaccine candidate L91, which is composed of lipidated promiscuous MHC-II binder epitope, derived from latency associated Acr1 antigen of Mtb is immunogenic in the murine and Guinea pig models of TB and conferred better protection than BCG against Mtb...
October 11, 2018: Journal of Translational Medicine
Anastasios Loizos, Elpidoforos S Soteriades, Despo Pieridou, Maria G Koliou
BACKGROUND: Non-tuberculous Mycobacteria (NTM) constitute an important cause of cervical lymphadenitis in immunocompetent children. In this study we aimed at estimating the incidence of lymphadenitis due to NTM in children in Cyprus and describe the characteristics, diagnostic approaches, management and outcomes of such infections. METHODS: Children between the ages 1 to 5 years old, evaluated at our hospital from January 1st 2007 to December 31st 2016 for lymphadenopathy were included in the study...
October 5, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Gökhan Sargın, Taşkın Şentürk, Emel Ceylan, Murat Telli, Songül Çildağ, Hakan Doğan
Introduction: Before starting tumour necrosis factor (TNF)-α blocking agents, standard tests should be used for the diagnosis of tuberculosis infection. The specificity of traditional tuberculin skin test (TST) is low in immunosuppressed patients due to prior Bacille Calmette Guérin (BCG) vaccination, non-tuberculous mycobacteria infections, false positive and negative results. In this study, we aimed to compare TST and Interferon-Gamma Release Assay (IGRA) tests for detecting latent tuberculosis infection in patients with rheumatic disease planned to receive TNF-α blocking agents...
June 2018: Tüberküloz Ve Toraks
Miguel Costa-Silva, Artur César, Preto Gomes Nuno, Filomena Azavedo
Mycobacterium abscessus (M. abscessus) is a non-tuberculous mycobacterium widely present in the natural environment and is now being increasingly identified as a cause of human disease. However, it can cause skin and soft tissue infection following trauma or surgery. We report a case of a skin ulcer associated with M. abscessus in a spa worker. Frequently, contamination with atypical mycobacteria occurs through tap water. However, in most outbreaks the infection source remains unknown. For an early diagnosis, it is important to perform biopsies and mycobacterium cultures...
September 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Vitalii Litvinov, Marina Makarova, Ksenia Galkina, Elena Khachaturiants, Maria Krasnova, Lidia Guntupova, Svetlana Safonova
OBJECTIVE: The objective of the research was to assess the susceptibility of the slowly growing nontuberculous mycobacteria strains to the antimicrobial drugs used for mycobaterioses treatment using SLOMYCO test system. MATERIALS AND METHODS: We assessed 363 NTM strains: 177 MAC (161 M. avium, 16 M. intracellulare), 112 M. kansasii and 74 M. xenopi collected from the respiratory material of the patients were under the treatment or under diagnostic procedures at our Center, affiliates and the diagnostic department in 2010-2016...
2018: PloS One
Hye-Young Wang, Kwangjin Ahn, Young Uh, Hyeyoung Lee, Seoyong Kim, Yunhee Chang, Chulhun L Chang, Tae-Sun Shim
Rapid and accurate detection of rifampin-resistant Mycobacterium tuberculosis (MTB) is of primary importance for infection control and selection of anti-tuberculosis drugs. The aim of this study was to evaluate the usefulness of a newly developed multiplexed, bead-based bioassay (Quantamatrix Multiplexed Assay Platform, QMAP) for the direct detection of rifampin-resistant MTB in respiratory specimens. A total of 400 respiratory specimens collected from patients with clinically suspected tuberculosis or non-tuberculous mycobacteria (NTM) infections were tested with the culture-based conventional Mycobacterium species identification and QMAP system...
2018: Frontiers in Microbiology
M van Mechelen, J van der Hilst, I C Gyssens, P Messiaen
Non-tuberculous mycobacteria are a known cause of skin and soft tissue infections. However, only too often it takes inordinately long to arrive at the appropriate diagnosis and start treatment. Actively searching for predilection factors, exposure risks and specific clinical clues may speed up the diagnostic process. Deep tissue biopsy cultures are indispensable to determine the species and strain of mycobacterium, with important consequences for treatment. Less well known as a causative agent of prolonged tenosynovitis is Mycobacterium tuberculosis...
August 2018: Netherlands Journal of Medicine
Stefano Aliberti, Luigi Ruffo Codecasa, Andrea Gori, Giovanni Sotgiu, Maura Spotti, Antonio Di Biagio, Andrea Calcagno, Stefano Nardini, Baroukh Maurice Assael, Enrico Tortoli, Giorgio Besozzi, Maurizio Ferrarese, Alberto Matteelli, Enrico Girardi, Saverio De Lorenzo, Manuela Seia, Andrea Gramegna, Bruno Del Prato, Leonardo Terranova, Martina Oriano, Nicola Sverzellati, Mehdi Mirsaeidi, James D Chalmers, Charles S Haworth, Michael R Loebinger, Timothy Aksamit, Kevin Winthrop, Felix C Ringshausen, Giuliana Previdi, Francesco Blasi
Background: A substantial increase in pulmonary and extra-pulmonary diseases due to non-tuberculous mycobacteria (NTM) has been documented worldwide, especially among subjects suffering from chronic respiratory diseases and immunocompromised patients. Many questions remain regarding the epidemiology of pulmonary disease due to NTM (NTM-PD) mainly because reporting of NTM-PD to health authorities is not mandated in several countries, including Italy. This manuscript describes the protocol of the first Italian registry of adult patients with respiratory infections caused by NTM (IRENE)...
2018: Multidisciplinary Respiratory Medicine
Abhishek Shenoy, Walid El-Nahal, McCall Walker, Tushar Chopra, Gregory Townsend, Scott Heysell, Joshua Eby
Mycobacterium immunogenum is a member of the rapidly growing non-tuberculous mycobacteria and is a relatively new species identified within this group. An 81-year-old immune-competent male was diagnosed with M. immunogenum infection of his peritoneal dialysis catheter exit site and surrounding soft tissue. To our knowledge, this is the first reported case of M. immunogenum infection of a peritoneal catheter. Treatment included catheter removal, local surgical debridement, and combination antimicrobial therapy...
August 21, 2018: Infection
Gurpreet S Bhalla, Manbeer S Sarao, Dinesh Kalra, Kuntal Bandyopadhyay, Arun Ravi John
Non-tuberculous mycobacteria (NTM) are composed of mycobacterial species other than the Mycobacterium tuberculosis complex. Initially thought to be mere contaminants when isolated from clinical specimens, literature is increasing by the day showing NTM as proven pathogens. Due to the difference in antimicrobial susceptibility of different species, it becomes imperative for the microbiology laboratory to identify them to the species level. Molecular methods are available for rapid and accurate identification, but in a resource limited nation, phenotypic methods, albeit time consuming, are of paramount importance...
November 2018: Practical Laboratory Medicine
Imran Sulaiman, Benjamin G Wu, Yonghua Li, Adrienne S Scott, Patrick Malecha, Benjamin Scaglione, Jing Wang, Ashwin Basavaraj, Samuel Chung, Katrina Bantis, Joseph Carpenito, Jose C Clemente, Nan Shen, Jamie Bessich, Samaan Rafeq, Gaetene Michaud, Jessica Donington, Charissa Naidoo, Grant Theron, Gail Schattner, Suzette Garofano, Rany Condos, David Kamelhar, Doreen Addrizzo-Harris, Leopoldo N Segal
Aspiration is associated with nontuberculous mycobacterial (NTM) pulmonary disease and airway dysbiosis is associated with increased inflammation. We examined whether NTM disease was associated with a distinct airway microbiota and immune profile.297 oral wash and induced sputum samples were collected from 106 participants with respiratory symptoms and imaging abnormalities compatible with NTM. Lower airway samples were obtained in 20 participants undergoing bronchoscopy. 16S rRNA gene and nested mycobacteriome sequencing approaches characterised microbiota composition...
October 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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