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JOURNAL ARTICLE
Xiaofei Ye, Panpan Hu, Bin Yang, Yang Yang, Ding Gao, Ginger Qinghong Zeng, Kai Wang
PURPOSE: Some individuals with idiopathic focal epilepsy (IFE) experience recurring seizures accompanied by the evolution of electrical status epilepticus during sleep (ESES). Here, we aimed to develop a predictor for the early detection of seizure recurrence with ESES in children with IFE using resting state electroencephalogram (EEG) data. METHODS: The study group included 15 IFE patients who developed seizure recurrence with ESES. There were 17 children in the control group who did not experience seizure recurrence with ESES during at least 2-year follow-up...
March 27, 2024: Seizure: the Journal of the British Epilepsy Association
#2
JOURNAL ARTICLE
Xiufeng Wang, Yanling Zhang, Ruixue Sun, Na Kong
OBJECTIVE: To explore risk factors of electrical status epilepticus during sleep in children with benign childhood epilepsy with centro-temporal spikes (BECT). METHODS: This is a clinical comparative study. The subjects of study were 67 children with BECT from the Outpatient Department of Pediatric Neurology in Xingtai People's Hospital from January 2019 to January 2022. According to the occurrence of ESES, the enrolled children were divided into control group which included BECT children without ESES and the observation group which included BECT children with ESES...
2024: Pakistan Journal of Medical Sciences Quarterly
#3
REVIEW
Rudolf Korinthenberg, Thomas Bast, Edda Haberlandt, Ulrich Stephani, Adam Strzelczyk, Gerta Rücker
We conducted a systematic review investigating the efficacy and tolerability of adrenocorticotropic hormone (ACTH) and corticosteroids in children with epilepsies other than infantile epileptic spasm syndrome (IESS) that are resistant to anti-seizure medication (ASM). We included retrospective and prospective studies reporting on more than five patients and with clear case definitions and descriptions of treatment and outcome measures. We searched multiple databases and registries, and we assessed the risk of bias in the selected studies using a questionnaire based on published templates...
February 27, 2024: Epilepsia
#4
JOURNAL ARTICLE
Emily Matuska, Allison Carney, Leigh N Sepeta, Tesfaye Zelleke, Archana Pasupuleti, Madison M Berl
The NIH Toolbox Cognition Battery (NIHTB-CB) is designed to assess cognitive functioning across the lifespan. We aimed to evaluate the clinical validity of two NIHTB-CB tasks as cognitive screening tools in pediatric epilepsy by comparing them to standard neuropsychological measures and their association with epilepsy characteristics. Forty-seven patients with epilepsy ages 5-18, including ten repeat evaluations, were assessed. Correlational analyses and agreement statistics were conducted to validate NIHTB-CB tasks (Flanker Inhibitory Control and Attention test (Flanker) and Pattern Comparison Processing Speed test (Pattern Comparison)) with standard clinical measures...
February 23, 2024: Epilepsy & Behavior: E&B
#5
REVIEW
Annio Posar, Paola Visconti
In the context of childhood epilepsy, the concept of continuous spike-waves during slow sleep (CSWS) includes several childhood-onset heterogeneous conditions that share electroencephalograms (EEGs) characterized by a high frequency of paroxysmal abnormalities during sleep, which have negative effects on the cognitive development and behavior of the child. These negative effects may have the characteristics of a clear regression or of a slowdown in development. Seizures are very often present, but not constantly...
January 28, 2024: Children
#6
JOURNAL ARTICLE
Yılmaz Yıldız, Didem Ardıçlı, Rahşan Göçmen, Dilek Yalnızoğlu, Meral Topçu, Turgay Coşkun, Ayşegül Tokatlı, Göknur Haliloğlu
OBJECTIVE: To evaluate clinical characteristics and long-term outcomes in patients with guanidinoacetate methyltransferase (GAMT) deficiency with a special emphasis on seizures and electroencephalography (EEG) findings. METHODS: We retrospectively analyzed the clinical and molecular characteristics, seizure types, EEG findings, neuroimaging features, clinical severity scores, and treatment outcomes in six patients diagnosed with GAMT deficiency. RESULTS: Median age at presentation and diagnosis were 11...
February 15, 2024: European Journal of Paediatric Neurology: EJPN
#7
JOURNAL ARTICLE
Esra Yildiz, Takayuki Iwayama, Izumi Kuramochi
AIM: We translated the Epilepsy Self-stigma Scale (ESSS) into Turkish and aimed to examine the Turkish version ESSS (ESSS-T) validity and reliability. MATERIALS AND METHOD: From April to August 2023, patients with epilepsy (PWE) were recruited from the neurology outpatient clinic of Ataturk University Hospital in the eastern Turkish city of Erzurum (inclusion criteria: age 18 years or older and adequate reading and speaking ability in Turkish). We conducted our survey using a self-administered questionnaire...
December 30, 2023: Epilepsy & Behavior: E&B
#8
REVIEW
Kevin E Chapman, Dietrich Haubenberger, Eric Jen, Athena Tishchenko, Trung Nguyen, Carolyn McMicken
INTRODUCTION: Developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep (D/EE-SWAS), also referred to as electrical status epilepticus during sleep (ESES) or epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS or EE-CSWS), is a spectrum of rare childhood epileptic encephalopathies that can lead to long-term cognitive impairment. Despite the importance of early diagnosis and intervention for D/EE-SWAS, there is a paucity of well-controlled clinical trial data to inform treatment, and no approved treatments are available...
January 2024: Epilepsy Research
#9
JOURNAL ARTICLE
Benedetta Kassabian, Amanda M Levy, Elena Gardella, Angel Aledo-Serrano, Amitha L Ananth, Alejandro J Brea-Fernández, Roseline Caumes, Nicolas Chatron, Alice Dainelli, Matthias De Wachter, Anne-Sophie Denommé-Pichon, Thomas J Dye, Elisa Fazzi, Roxanne Felt, Alberto Fernández-Jaén, Montserrat Fernández-Prieto, Emily Gantz, Piotr Gasperowicz, Antonio Gil-Nagel, David Gómez-Andrés, Hansel M Greiner, Renzo Guerrini, Maria K Haanpää, Minttu Helin, Juliane Hoyer, Anna C E Hurst, Staci Kallish, Shefali N Karkare, Amjad Khan, Lotte Kleinendorst, Johannes Koch, Sanjeev V Kothare, Suzanna V Koudijs, Lieven Lagae, Phillis Lakeman, Kathleen A Leppig, Gaetan Lesca, Diego Lopergolo, Laina Lusk, Alex Mackenzie, Davide Mei, Rikke S Møller, Elaine M Pereira, Konrad Platzer, Chloe Quelin, Anya Revah-Politi, Sylvain Rheims, Agustí Rodríguez-Palmero, Andrea Rossi, Filippo Santorelli, Syndi Seinfeld, Erick Sell, Donna Stephenson, Krzysztof Szczaluba, Eugen Trinka, Muhammad Umair, Hilde Van Esch, Mieke M van Haelst, Danielle C M Veenma, Sacha Weber, Sarah Weckhuysen, Pia Zacher, Zeynep Tümer, Guido Rubboli
OBJECTIVE: The postsynaptic density protein of excitatory neurons PSD-95 is encoded by DLG4, de novo pathogenic variants of which lead to DLG4-related synaptopathy. The major clinical features are developmental delay, intellectual disability (ID), hypotonia, sleep disturbances, movement disorders, and epilepsy. Even though epilepsy is present in 50% of the individuals, it has not been investigated in detail. We describe here the phenotypic spectrum of epilepsy and associated comorbidities in patients with DLG4-related synaptopathy...
December 22, 2023: Epilepsia
#10
RANDOMIZED CONTROLLED TRIAL
Marleen M L van Arnhem, Bart van den Munckhof, Alexis Arzimanoglou, Emilio Perucca, Liisa Metsähonkala, Guido Rubboli, Marianne Søndergaard Khinchi, Anne de Saint-Martin, Kerstin A Klotz, Julia Jacobs, J Helen Cross, Irene Garcia Morales, Wim M Otte, Heleen C van Teeseling, Frans S S Leijten, Kees P J Braun, Floor E Jansen
BACKGROUND: Epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) is a rare syndrome associated with cognitive and behavioural regression. On the basis of mostly small observational and retrospective studies, corticosteroids and clobazam are often considered the most effective treatments for this syndrome. We aimed to compare cognitive outcomes of children with EE-SWAS 6 months after starting treatment with either corticosteroids or clobazam. METHODS: We did a multicentre, randomised controlled trial at eight tertiary referral centres for rare epilepsies in seven European countries...
February 2024: Lancet Neurology
#11
REVIEW
John R McLaren, Kristopher T Kahle, R Mark Richardson, Catherine J Chu
Epileptic encephalopathies are defined by the presence of frequent epileptiform activity that causes neurodevelopmental slowing or regression. Here, we review evidence that epilepsy surgery improves neurodevelopment in children with epileptic encephalopathies. We describe an example patient with epileptic encephalopathy without drug refractory seizures, who underwent successful diagnostic and therapeutic surgeries. In patients with epileptic encephalopathy, cognitive improvement alone is a sufficient indication to recommend surgical intervention in experienced centers...
January 2024: Neurosurgery Clinics of North America
#12
JOURNAL ARTICLE
Madhur K Srivastava, Afshan J Shaik, Sireesha Yareeda, Kavitha Nallapareddy, Lokesh Lingappa, Pallavi Moturi, Padmaja Gaddamonugu, Rukmini M Kandadai, Rupam Borgohain
Objective Electrical status epilepticus in sleep (ESES) is defined by near-continuous epileptiform discharges during sleep along with cognitive, behavioral, and/or imaging abnormalities. We studied the neurocognitive profile and their correlation with 18 F fluorodeoxyglucose positron emission tomography (FDG PET) brain abnormalities in children with ESES. Methods Fourteen children with ESES with normal magnetic resonance imaging (MRI) from March to December 2019 were included. The intelligence quotient (IQ) and child behavior checklist (CBCL) scores were estimated using validated scales, and FDG PET brain was done at the same point of time to look for cerebral metabolic defects which was compared with a control group...
September 2023: World Journal of Nuclear Medicine
#13
JOURNAL ARTICLE
Jill Morales, Jaqueline Abrisqueta Gomez, Ana Castillo, Erica K Johnson, Robert T Fraser, Jason A D Smith
OBJECTIVE: Explore relationships between the years of education, mood, and anxiety with self-efficacy and self-management in Spanish-speaking people with epilepsy (PWE). Higher education was hypothesized to be associated with higher Epilepsy Self-Efficacy Scale (ESE) and Epilepsy Self-Management (ESM) scores, while lower mood and anxiety may be linked to lower ESE and ESM scores. METHOD: Spanish-speaking PWE completed the ESE, ESM, PHQ-9 andGAD-7. Participants were primarily monolingual, immigrant patients at a public, safety-net hospital in Dallas, TX enrolled in a self-management intervention study, PACES in Español...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
#14
JOURNAL ARTICLE
Snehal Shah, Soumya Ghosh, Lakshmi Nagarajan
Electrical Status epilepticus of sleep (SES) is an EEG pattern where there is significant activation of epileptiform activity in NREM sleep. A spike wave index (SWI) of > 80-85% is often labelled as typical SES. We aimed to explore if sleep during a standard daytime-EEG, as compared an overnight-EEG, was adequate to diagnose ESES. Ten children with daytime and overnight studies suggestive of SES were audited. SWI and Spike Wave Density (SWD) were calculated for 5-minute epochs of wake in the daytime and overnight study, as well daytime-EEG sleep and first and last NREM cycle in the overnight-EEG...
2023: Epilepsy & behavior reports
#15
JOURNAL ARTICLE
Han Zhang, Lisi Yan, Xiaoling Peng, Li Jiang, Junjiao Zhang, Jin Chen, Yue Hu
OBJECTIVE: To simplify the electroencephalogram (EEG) diagnosis and guide the treatment of electrical status epilepticus during sleep (ESES). METHODS: We recruited 54 children with ESES from December 2019 to December 2020 and compared various spike-wave index (SWI) calculation methods. Time-frequency analysis assessed the correlation between high-frequency oscillations energy and the SWI. We divided 42 children into responder and non-responder treatment groups based on the observations made during a 12-month follow-up period and evaluate different treatment and the independent risk factors of refractory ESES...
July 5, 2023: Epileptic Disorders: International Epilepsy Journal with Videotape
#16
JOURNAL ARTICLE
Guangshuang Lu, Yun Cheng, Yun Wang, Jie Hu, Fan Zhang, Wenbo Li, Minnong Xia, Xiaoyan Lu, Wu Yang
Objective . To investigate the prevalence and risk factors for electrical status epilepticus during slow-wave sleep (ESES) in patients with self-limited epilepsy with centrotemporal spikes (SeLECTS). Methods. The clinical and follow-up data of children with SeLECTS were collected between 2017 and 2021. Patients were divided into typical ESES, atypical ESES, and non-ESES groups according to spike-wave indices (SWI). Clinical and electroencephalography characteristics were retrospectively analyzed. Logistic regression was used to identify risk factors for ESES...
June 18, 2023: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
#17
JOURNAL ARTICLE
Yujiao Yang, Yixian Han, Jing Wang, Yongkang Zhou, Dong Chen, Mengyang Wang, Tianfu Li
OBJECTIVES: Patients with self-limited epilepsy with centrotemporal spikes (SeLECTS) with electrical status epilepticus in sleep (ESES) have generalized cognitive impairment, yet treatment options are limited. Our study aimed to examine the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on SeLECTS with ESES. In addition, we applied electroencephalography (EEG) aperiodic components (offset and slope) to investigate the improvement of rTMS on the excitation-inhibition imbalance (E-I imbalance) in the brain of this group of children...
2023: Frontiers in Neurology
#18
MULTICENTER STUDY
Miray Atacan Yaşgüçlükal, Senem Ayça, Veysi Demirbilek, Sema Saltık, Cengiz Yalçınkaya, Yasemin Erdoğan Döventaş, Özlem Çokar
BACKGROUND: Epileptic encephalopathy with spike-and-wave activation in sleep (EE-SWAS) is a syndrome of childhood, characterized by diffuse or generalized spike-wave activity in electroencephalography during non-rapid eye movement sleep. Neuropeptides have been demonstrated in several studies to function in the sleep-wake cycle and display convulsant and anticonvulsant features. In this study, we aimed to investigate the relationship between EE-SWAS and neuropeptides such as dynorphin, galanin, ghrelin, leptin, melatonin, and orexin...
July 2023: Pediatric Neurology
#19
JOURNAL ARTICLE
Chunmei Yang, Nan Jiang, Lulu Wu, Kaili Zhang, Xiaocui Wang, Bin Yang
OBJECTIVE: We investigated the characteristics and factors influencing eye emotion recognition in self-limited epilepsy patients with centrotemporal spikes (SeLECTS) complicated with electrical status epilepticus during sleep (ESES). METHODS: We selected SeLECTS (n = 160) patients treated in the outpatient and inpatient departments of Anhui Children's Hospital from September 2020 to January 2022. According to the video electroencephalogram monitoring slow-wave index (SWI), SeLECTS patients with SWI < 50% were assigned into the typical SeLECTS group (n = 79), and patients with SWI ≥ 50% were assigned into the ESES group (n = 81)...
July 2023: Brain and Behavior
#20
MULTICENTER STUDY
Hanin Alsini, Abdulaziz Alghamdi, Shatha Alshafi, Khalid Hundallah, Sameer Almehmadi, Daad Alsowat, Suad Al-Yamani, Hanin Almuzaini, Ali Alwadie, Ali Al-Otaibi, Lamyaa Jad, Asma Almadhi, Fahad Bashiri, Amal Kentab, Muddathir H Hamad, Duaa Baarmah, Mohammed Alrifaie, Mohammed Almuqbel, Raidah Al Baradie, Ali Meer, Mohammed Jan, Osama Muthaffar, Mohammed Aljabri, Elsayed Ali, Mohammed Saeed, Abeer Matar, Brahim Tabarki
OBJECTIVES: To investigate the clinical features of developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep (D/EE-SWAS), its electrographic characteristics, and etiology and to compare the effects of different treatment strategies on the outcomes using a Saudi Arabian database. METHODS: This multicenter study included children with D/EE-SWAS who were evaluated between 2010 and 2020 at 11 tertiary centers. Data were collected on their baseline clinical features, etiologies, and treatment modalities...
April 2023: Seizure: the Journal of the British Epilepsy Association
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