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https://www.readbyqxmd.com/read/29144054/a-strontium-and-chlorine-free-pyrotechnic-illuminant-of-high-color-purity
#1
Thomas M Klapötke, Magdalena Rusan, Joerg Stierstorfer, Jesse Sabatini, Johann Glueck
The need to develop a red-light-emitting pyrotechnic illuminant has garnered interest from the pyrotechnics community due to potential Environmental Protection Agency (EPA) regulations of strontium and chlorinated organic materials. To address these environmental regulatory concerns, the development of lithium-based red-light-emitting pyrotechnic compositions of high purity and color is described. These formulations do not contain strontium or chlorinated organic materials. Rather, the disclosed formulations are based on a non-hygroscopic dilithium high-nitrogen salt which serves as both the oxidizer and red colorant...
November 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29142166/fish-oil-feeding-reverses-hepatomegaly-and-disrupted-hepatic-function-due-to-the-lack-of-fxr-signaling
#2
Masaaki Miyata, Kouhei Shinno, Tomoki Kinoshita, Yuichi Kinoshita, Yoshimasa Sugiura
Mice lacking farnesoid X receptor (FXR) are used as a model for nonalcoholic fatty liver disease because their livers exhibit hepatomegaly, hepatic steatosis, and hepatic inflammation. The influence of fish oil feeding on hepatomegaly and disrupted hepatic function was investigated using female Fxr-null mice and wild-type mice fed a fish oil diet (2% fish oil and 2% corn oil) or a control diet (4% corn oil) for 4 weeks. Hepatic n-3 polyunsaturated fatty acid (PUFA) levels, including 22:6 n-3 docosahexaenoic acid (DHA) and 20:5 n-3 eicosapentaenoic acid (EPA) were significantly higher in the fish oil group than those in the control group of Fxr-null mice and wild-type mice...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29141086/use-of-entrustable-professional-activities-in-the-assessment-of-surgical-resident-competency
#3
Justin P Wagner, Catherine E Lewis, Areti Tillou, Vatche G Agopian, Chi Quach, Timothy R Donahue, O Joe Hines
Importance: Competency-based assessments of surgical resident performance require metrics of entrustable autonomy. Objectives: To designate entrustable professional activities (EPAs) in global performance and in specific operations, and to identify differences in perceived capability, autonomy, and expectations between surgical faculty and residents. Design, Setting, and Participants: This survey study was conducted from August 9, 2016, through August 24, 2016, in the Department of Surgery at the UCLA David Geffen School of Medicine...
November 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29139484/ftir-imaging-detects-diet-and-genotype-dependent-chemical-composition-changes-in-wild-type-and-mutant-c-elegans-strains
#4
A Bouyanfif, S Liyanage, J E Hewitt, S A Vanapalli, N Moustaid-Moussa, E Hequet, N Abidi
This study focuses on the use of Fourier Transform Infrared (FTIR) microspectroscopy to determine chemical changes induced in the nematode Caenorhabditis elegans by supplementation of C. elegans maintenance media (CeMM) by Eicosapentaenoic acid (EPA). Wild-type C. elegans (N2) and mutant strains (tub-1 and fat-3) were grown in CeMM alone, and CeMM supplemented with EPA at 25 or 100 μM. Feeding was performed for 72 h. FTIR imaging was performed in transmission mode on individual worms. The FTIR imaging analysis of wild-type animals revealed the presence of vibrations assigned to unsaturated fatty acids, specifically bands at 3008 cm(-1) ([double bond, length as m-dash]C-H, olefinic stretch) and 1744 cm(-1) (C[double bond, length as m-dash]O, unsaturated fatty acids)...
November 15, 2017: Analyst
https://www.readbyqxmd.com/read/29138771/near-infrared-aza-bodipy-fluorescent-probe-for-selective-cu-2-detection-and-its-potential-in-living-cell-imaging
#5
Yordkhuan Tachapermpon, Sopida Thavornpradit, Adisri Charoenpanich, Jitnapa Sirirak, Kevin Burgess, Nantanit Wanichacheva
A near-infrared (NIR) fluorescent sensor 1 composed of an aza-boron-dipyrromethene (aza-BODIPY) core covalently bound to two di-2-picolylamine moieties was conceived for Cu(2+) detection in aqueous solutions. Spectroscopic properties and binding abilities with several metal ions were investigated in phosphate buffered saline (pH 7.4): acetonitrile (95 : 5 v/v) with Triton X-100 via fluorometric titrations. The fluorescence of sensor 1 was quenched selectively by cupric ions in the presence of alkali- and transition-metal-ions...
November 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29137111/effect-of-omega-3-fatty-acid-supplementation-on-plasma-fibroblast-growth-factor-23-levels-in-post-myocardial-infarction-patients-with-chronic-kidney-disease-the-alpha-omega-trial
#6
Martin H de Borst, Leandro C Baia, Ellen K Hoogeveen, Erik J Giltay, Gerjan Navis, Stephan J L Bakker, Johanna M Geleijnse, Daan Kromhout, Sabita S Soedamah-Muthu
Fibroblast growth factor 23 (FGF23) is an independent risk factor for cardiovascular mortality in chronic kidney disease. Omega-3 (n-3) fatty acid consumption has been inversely associated with FGF23 levels and with cardiovascular risk. We examined the effect of marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and plant-derived alpha-linolenic acid (ALA) on plasma FGF23 levels in post-myocardial infarction patients with chronic kidney disease. In the randomized double-blind Alpha Omega Trial, 4837 patients with a history of myocardial infarction aged 60-80 years (81% men) were randomized to one of four trial margarines supplemented with a targeted additional intake of 400 mg/day EPA and DHA, 2 g/day ALA, EPA-DHA plus ALA, or placebo for 41 months...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29136878/highly-sensitive-and-selective-turn-on-fluorescent-chemosensors-for-hg-2-based-on-thioacetal-modified-pyrene
#7
Yunyan Gao, Tuotuo Ma, Zhize Ou, Wenjiao Cai, Guoqiang Yang, Yi Li, Moheng Xu, Qingqing Li
This work reports a facile strategy for the synthesis of water-soluble fluorescent probes Pyr1 and Pyr2, which have carboxyl and hydroxyl group in the side chain of thioacetal moiety, respectively. Pyr1-2 exhibit exclusively selective turn-on fluorescence response towards Hg(2+) over other cations, based on intramolecular charge transfer (ICT) mechanism. Upon addition of Hg(2+), the thioacetal moiety in Pyr1-2 can be converted to aldehyde group, which is confirmed by (1)H NMR titrations. The detection limits for Pyr1-2 are less than 1...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136623/synergistic-effect-of-eicosapentaenoic-acid-on-antiproliferative-action-of-anticancer-drugs-in-a-cancer-cell-line-model
#8
Ayako Ogo, Sachi Miyake, Hisako Kubota, Masaharu Higashida, Hideo Matsumoto, Fusako Teramoto, Toshihiro Hirai
BACKGROUND/AIMS: It has been found experimentally and clinically that eicosapentaenoic acid (EPA) exerts an anticancer effect and that it has a minimal adverse event profile relative to other anticancer drugs. Any synergy between EPA and other anticancer drugs could be of therapeutic relevance, especially in elderly or high-risk patients. Therefore, we investigated the synergism between anticancer drugs and EPA experimentally. METHODS: EPA was coadministered in vitro with various anticancer drugs (paclitaxel, docetaxel, 5-fluorouracil and cis-diamminedichloridoplatinum[II]) to TE-1 cells, which were derived from human esophageal cancer tumors...
November 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29136473/structural-investigation-of-bulk-and-dispersed-inverse-lyotropic-hexagonal-liquid-crystalline-phases-of-eicosapentaenoic-acid-monoglyceride
#9
Anan Yaghmur, Sabah Al-Hosayni, Heinz Amenitsch, Stefan Salentinig
Recent studies demonstrated the potential therapeutic use of newly synthesized omega-3 (ω-3) polyunsaturated fatty acid (PUFA) monoglycerides owing to their beneficial health effects in various disorders including cancer and inflammation diseases. To date, the research was mainly focused on exploring the biological effects of these functional lipids. However, to the best of our knowledge, there is no report on the hydration-mediated self assembly of these lipids that leads to the formation of nanostructures, which are attractive for use as vehicles for the delivery of drugs and functional foods...
November 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29133307/the-anti-inflammatory-effect-of-personalized-omega-3-fatty-acid-dosing-for-reducing-prostaglandin-e2-in-the-colonic-mucosa-is-attenuated-in-obesity
#10
Zora Djuric, D Kim Turgeon, Ananda Sen, Jianwei Ren, Kirk Herman, Devon Ramaswamy, Lili Zhao, Mack T Ruffin, Daniel P Normolle, William L Smith, Dean E Brenner
This clinical trial developed a personalized dosing model for reducing prostaglandin E2 (PGE2) in colonic mucosa using ω-3 fatty acid supplementation. The model utilized serum eicosapentaenoic acid (EPA, ω-3):arachidonic acid (AA, ω-6) ratios as biomarkers of colonic mucosal PGE2 concentration. Normal human volunteers were given low and high ω-3 fatty acid test doses for 2 weeks. This established a slope and intercept of the line for dose versus serum EPA:AA ratio in each individual. The slope and intercept was utilized to calculate a personalized target dose that was given for 12 weeks...
November 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29128248/adsorption-of-1-2-3-trichloropropane-tcp-to-meet-a-mcl-of-5%C3%A2-ppt
#11
Roger W Babcock, Bryce K Harada, Krishna M Lamichhane, Korey T Tsubota
1,2,3-Trichloropropane (TCP) is a groundwater contaminant in the drinking water aquifers in Hawaii and some other states. Granular activated carbon (GAC) has been used for 30 years to treat approximately 60 million gallons per day of TCP-contaminated groundwater in Hawaii. The State of Hawaii's current maximum contaminant level (MCL) for TCP is 600 ng/L (ppt), and consideration is being given to lower the MCL to 5 ppt. There is no EPA MCL for TCP. A study was conducted to determine if any GAC could meet a 5 ppt MCL for TCP, and if so, how many bedvolumes (BVs) could be treated prior to breakthrough...
November 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29125943/effects-of-chilled-and-frozen-storage-conditions-on-the-lamb-m-longissimus-lumborum-fatty-acid-and-lipid-oxidation-parameters
#12
Cassius E O Coombs, Benjamin W B Holman, Eric N Ponnampalam, Stephen Morris, Michael A Friend, David L Hopkins
This study investigated the effects of chilled and frozen storage conditions on the fatty acid profile and lipid oxidation in lamb M. longissimus lumborum (LL). Muscle LL (n=360) were randomly selected at 24h post-mortem from a commercial Australian abattoir and maintained chilled for five periods (0, 2, 4, 6 and 8weeks) followed by frozen for six periods (0, 4, 8, 12, 24 and 52weeks) at -12°C or -18°C. Samples were analysed for fatty acid profile and lipid oxidative parameters (TBARS, oxidation-reduction potential and peroxidase activity)...
October 19, 2017: Meat Science
https://www.readbyqxmd.com/read/29124425/steroid-hormones-in-environmental-matrices-extraction-method-comparison
#13
Gangadhar Andaluri, Rominder P S Suri, Kendon Graham
The U.S. Environmental Protection Agency (EPA) has developed methods for the analysis of steroid hormones in water, soil, sediment, and municipal biosolids by HRGC/HRMS (EPA Method 1698). Following the guidelines provided in US-EPA Method 1698, the extraction methods were validated with reagent water and applied to municipal wastewater, surface water, and municipal biosolids using GC/MS/MS for the analysis of nine most commonly detected steroid hormones. This is the first reported comparison of the separatory funnel extraction (SFE), continuous liquid-liquid extraction (CLLE), and Soxhlet extraction methods developed by the U...
November 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29121897/differences-between-medical-student-and-faculty-perceptions-of-the-competencies-needed-for-the-first-year-of-residency
#14
Sophie Fürstenberg, Sigrid Harendza
BACKGROUND: Different guidelines and frameworks like the CanMEDs model or entrustable professional activities (EPAs) describe competencies required for successful and professional work of residents. Not all competencies are of equal importance for graduates when they start their residency. The aim of this study was to evaluate the relevance of different competencies for a first year resident from the perspective of physicians and medical students. METHODS: In an online study, 178 of 475 surgeons and internists including residents and attendings and 102 of 728 first and last year undergraduate medical students from the University Medical Center Hamburg-Eppendorf ranked 25 competencies according to their relevance for entrustment decisions in first year residents...
November 9, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29121603/assessment-of-light-extinction-at-a-european-polluted-urban-area-during-wintertime-impact-of-pm1-composition-and-sources
#15
R Vecchi, V Bernardoni, S Valentini, A Piazzalunga, P Fermo, G Valli
In this paper, results from receptor modelling performed on a well-characterised PM1 dataset were combined to chemical light extinction data (bext) with the aim of assessing the impact of different PM1 components and sources on light extinction and visibility at a European polluted urban area. It is noteworthy that, at the state of the art, there are still very few papers estimating the impact of different emission sources on light extinction as we present here, although being among the major environmental challenges at many polluted areas...
November 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29121093/fish-oil-omega-3-polyunsaturated-fatty-acids-attenuate-oxidative-stress-induced-dna-damage-in-vascular-endothelial-cells
#16
Chiemi Sakai, Mari Ishida, Hideo Ohba, Hiromitsu Yamashita, Hitomi Uchida, Masao Yoshizumi, Takafumi Ishida
OBJECTIVE: Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), likely prevent cardiovascular disease, however their mechanisms remain unclear. Recently, the role of DNA damage in atherogenesis has been receiving considerable attention. Here, we investigated the effects of EPA and DHA on DNA damage in vascular endothelial cells to clarify their antiatherogenic mechanisms. METHODS AND RESULTS: We determined the effect of EPA and DHA on H2O2-induced DNA damage response in human aortic endothelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/29120783/micro-emulsification-encapsulation-of-krill-oil-by-complex-coacervation-with-krill-protein-isolated-using-isoelectric-solubilization-precipitation
#17
Liu Shi, Sarah K Beamer, Hong Yang, Jacek Jaczynski
This study determined feasibility of krill protein isolated with isoelectric solubilization/precipitation (ISP) as wall material to microencapsulate krill oil by freeze-drying. Effects of krill oil/krill protein ratio on properties of microcapsules were investigated. With increased ratio, crude protein of microcapsules decreased, while total lipid increased. Although microcapsule oil loading capacity increased, loading and encapsulation efficiencies decreased. Thin layer chromatography (TLC) confirmed abundance of phospholipids, which are amphiphilic; and thus, resulted in stable emulsion (emulsion stability index)...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29119582/emotions-and-assessment-considerations-for-rater-based-judgements-of-entrustment
#18
Carlos Gomez-Garibello, Meredith Young
CONTEXT: Assessment is subject to increasing scrutiny as medical education transitions towards a competency-based medical education (CBME) model. Traditional perspectives on the roles of assessment emphasise high-stakes, summative assessment, whereas CBME argues for formative assessment. Revisiting conceptualisations about the roles and formats of assessment in medical education provides opportunities to examine understandings and expectations of the assessment of learners. The act of the rater generating scores might be considered as an exclusively cognitive exercise; however, current literature has drawn attention to the notion of raters as measurement instruments, thereby attributing additional factors to their decision-making processes, such as social considerations and intuition...
November 9, 2017: Medical Education
https://www.readbyqxmd.com/read/29119156/sequential-detection-of-fe-3-2-and-pyrophosphate-by-a-colorimetric-chemosensor-in-a-near-perfect-aqueous-solution
#19
Ju Byeong Chae, Hyo Jung Jang, Cheal Kim
A novel colorimetric chemosensor 1 was designed and synthesized for Fe(3+/2+) and pyrophosphate. Sensor 1 showed a selective color change toward both Fe(3+) and Fe(2+) from yellow to brown in a near-perfect aqueous solution. The detection limits (0.36 μM and 0.37 μM) for Fe(3+) and Fe(2+) were much lower than the guideline (5.37 μM) set by the Environmental Protection Agency (EPA) for iron in drinking water. Sensor 1 could be used to quantify Fe(3+) in real water samples. Moreover, the resulting Fe(3+)-2·1 complex can detect pyrophosphate selectively over various anions especially including phosphate-based anions through a metal-complex displacement method...
November 9, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29115671/fatty-acid-elongase-7-is-regulated-via-sp1-and-is-involved-in-lipid-accumulation-in-bovine-mammary-epithelial-cells
#20
Si Chen, Zhigang Hu, Hua He, Xiaolin Liu
Fatty Acid Elongase 7 (ELOVL7) is the newly discovered protein on human that catalyzes the rate-limiting step towards the synthesis of very long-chain fatty acids and exhibits the highest activity toward C18:3 (n-3) acyl-CoAs, which is the precursor of eicosapentaenoic acid (EPA, 20:5n-3). However, in ruminants, an overall understanding of ELOVLs gene family and the transcriptional regulation of ELOVL7 remain unknown. The purpose of this study is to investigate the transcriptional regulation and the influence of bovine ELOVL7 in bovine mammary epithelial cells (bMECs)...
November 8, 2017: Journal of Cellular Physiology
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