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https://www.readbyqxmd.com/read/28214744/tuning-of-the-selectivity-of-fluorescent-peptidyl-bioprobe-using-aggregation-induced-emission-for-heavy-metal-ions-by-buffering-agents-in-100-aqueous-solutions
#1
Lok Nath Neupane, Gi Won Hwang, Keun-Hyeung Lee
Smart fluorescent probes of which the detection of specific target molecules can be controlled are attracting remarkable interest. A fluorescent peptidyl bioprobe (1) was rationally synthesized by conjugating tetraphenylethylene, an aggregation-induced emission (AIE) fluorophore with a peptide receptor (AspHis) that acted as hard and intermediate bases. The selective detection of 1 for specific metal ion in 100% aqueous solutions was controlled by the buffering agents with the chelate effect without the change of pH...
February 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28214716/early-career-psychiatrists-preferences-on-e-learning-viewpoint-from-the-epa-committee-on-education
#2
EDITORIAL
M Casanova Dias, D Giacco, C Hanon
No abstract text is available yet for this article.
December 20, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28213750/effect-of-an-acute-dose-of-omega-3-fish-oil-following-exercise-induced-muscle-damage
#3
J R Jakeman, D M Lambrick, B Wooley, J A Babraj, J A Faulkner
PURPOSE: The purpose of this double-blind, placebo-controlled study was to examine the effect of two fish oil supplements, one high in EPA (750 mg EPA, 50 mg DHA) and one low in EPA (150 mg EPA, 100 mg DHA), taken acutely as a recovery strategy following EIMD. METHODS: Twenty-seven physically active males (26 ± 4 year, 1.77 ± 0.07 m, 80 ± 10 kg) completed 100 plyometric drop jumps to induce muscle damage. Perceptual (perceived soreness) and functional (isokinetic muscle strength at 60° and 180° s(-1), squat jump performance and countermovement jump performance) indices of EIMD were recorded before, and 1, 24, 48, 72, and 96h after the damaging protocol...
February 17, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28212390/lack-of-effects-of-fish-oil-supplementation-for-12-weeks-on-resting-metabolic-rate-and-substrate-oxidation-in-healthy-young-men-a-randomized-controlled-trial
#4
Sebastian Jannas-Vela, Kaitlin Roke, Stephanie Boville, David M Mutch, Lawrence L Spriet
: Fish oil (FO) has been shown to have beneficial effects in the body via incorporation into the membranes of many tissues. It has been proposed that omega-3 fatty acids in FO may increase whole body resting metabolic rate (RMR) and fatty acid (FA) oxidation in human subjects, but the results to date are equivocal. The purpose of this study was to investigate the effects of a 12 week FO supplementation period on RMR and substrate oxidation, in comparison to an olive oil (OO) control group, in young healthy males (n = 26; 22...
2017: PloS One
https://www.readbyqxmd.com/read/28205317/oxidative-stress-and-immunosenescence-in-spleen-of-obese-mice-can-be-reversed-by-2-hydroxyoleic-acid
#5
Alina Gheorghe, Fátima Pérez de Heredia, Caroline Hunsche, Noemí Redondo, Ligia Esperanza Díaz, Oskarina Hernández, Ascensión Marcos, Mónica De la Fuente
We aimed to investigate the effects of obesity on oxidative stress and leukocyte function in spleen of mice, and to assess whether supplementation with 2-hydroxyoleic acid (2-OHOA) or n-3 polyunsaturated fatty acids (PUFA) could reverse those effects. Female ICR/CD1 mice (8 weeks old, n = 24) received an obesogenic diet (22% fat for 4 weeks and 60% fat for 14 weeks). After 6 weeks, mice were split in three groups (n = 8/group): no supplementation, 2-OHOA supplementation (1500 mg kg(-1) ) and n-3 PUFA supplementation (EPA + DHA, 3000 mg kg(-1) diet)...
February 15, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28202745/plasma-levels-of-eicosapentaenoic-acid-are-associated-with-anti-tnf-responsiveness-in-rheumatoid-arthritis-and-inhibit-the-etanercept-driven-rise-in-th17-cell-differentiation-in-vitro
#6
Louisa Jeffery, Helena L Fisk, Philip C Calder, Andrew Filer, Karim Raza, Christopher D Buckley, Iain McInnes, Peter C Taylor, Benjamin A Fisher
OBJECTIVE: To determine whether levels of plasma n-3 polyunsaturated fatty acids are associated with response to antitumor necrosis factor (anti-TNF) agents in rheumatoid arthritis (RA), and whether this putative effect may have its basis in altering anti-TNF-driven Th17 cell differentiation. METHODS: Plasma was collected at baseline and after 3 months of anti-TNF treatment in 22 patients with established RA, and fatty acid composition of the phosphatidylcholine (PC) component was measured...
February 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28199946/bioavailability-and-bioaccessibility-of-polycyclic-aromatic-hydrocarbons-from-post-pyrolytically-treated-biochars
#7
Isabel Hilber, Philipp Mayer, Varvara Gouliarmou, Sarah E Hale, Gerard Cornelissen, Hans-Peter Schmidt, Thomas D Bucheli
Bioaccessibility data of PAHs from biochar produced under real world conditions is scarce and the influence of feedstock and various post-pyrolysis treatments common in agriculture, such as co-composting or lacto-fermentation to produce silage fodder, on their bioavailability and bioaccessibility has hardly been studied. The total (Ctotal), and freely dissolved (i.e., bioavailable) concentrations (Cfree) of the sum of 16 US EPA PAHs of 43 biochar samples produced and treated in such ways ranged from 0.4 to almost 2000 mg/kg, and from 12 to 81 ng/L, respectively, which resulted in very high biochar-water partition coefficients (4...
February 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28199878/large-decadal-scale-changes-in-uranium-and-bicarbonate-in-groundwater-of-the-irrigated-western-u-s
#8
Karen R Burow, Kenneth Belitz, Neil M Dubrovsky, Bryant C Jurgens
Samples collected about one decade apart from 1105 wells from across the U.S. were compiled to assess whether uranium concentrations in the arid climate are linked to changing bicarbonate concentrations in the irrigated western U.S. Uranium concentrations in groundwater were high in the arid climate in the western U.S, where uranium sources are abundant. Sixty-four wells (6%) were above the U.S. EPA MCL of 30μg/L; all but one are in the arid west. Concentrations were low to non-detectable in the humid climate...
February 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28198569/effect-of-eicosapentaenoic-acid-on-bovine-cumulus-oocyte-complex-in-vitro
#9
Noelia Nikoloff, Ana M Pascua, Juan M Anchordoquy, Juan P Anchordoquy, Matías A Sirini, Analia Seoane, Cecilia C Furnus
The aim of the present study was to investigate the effects of eicosapentaenoic acid (EPA) supplementation during in vitro maturation (IVM) of bovine oocytes. The concentrations tested in all experiments were 1 nM, 1 μM and 1 mM EPA. The effect of EPA was evaluated on cumulus-oocyte complexes (COC) by oocyte maturation [cumulus expansion area and oocyte nuclear maturation], genotoxicity [single cell gel electrophoresis (SCGE)] and cytotoxicity [apoptosis, viability and MTT assays] end points. The maturation parameters were affected by exposure of COC to different EPA concentrations in the IVM medium...
February 15, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28197979/no-effect-of-omega-3-carboxylic-acids-on-pharmacokinetics-pharmacodynamics-of-warfarin-or-on-platelet-function-when-co-administered-with-acetylsalicylic-acid-results-of-two-phase-i-studies-in-healthy-volunteers
#10
Elliot Offman, Michael Davidson, Catarina Nilsson
BACKGROUND: Omega-3 carboxylic acids (OM3-CA) can lower triglyceride levels. OBJECTIVE: Our objective was to assess the effects of OM3-CA on warfarin pharmacokinetics and pharmacodynamics and on acetylsalicylic acid (ASA)-dependent and independent platelet activation when co-administered with ASA in two phase I studies. METHODS: In ECLIPSE II (NCT01431690), 26 participants received warfarin 25 mg on days 1 and 22 and OM3-CA 4 g once daily from day 8 to day 28...
February 14, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28197856/determination-of-substrate-preferences-for-desaturases-and-elongases-for-production-of-docosahexaenoic-acid-from-oleic-acid-in-engineered-canola
#11
Jenny Lindberg Yilmaz, Ze Long Lim, Mirela Beganovic, Steven Breazeale, Carl Andre, Sten Stymne, Patricia Vrinten, Toralf Senger
Production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in plant seed oils has been pursued to improve availability of these omega-3 fatty acids that provide important human health benefits. Canola (Brassica napus), through the introduction of 10 enzymes, can convert oleic acid (OLA) into EPA and ultimately DHA through a pathway consisting of two elongation and five desaturation steps. Herein we present an assessment of the substrate specificity of the seven desaturases and three elongases that were introduced into canola by expressing individual proteins in yeast...
February 14, 2017: Lipids
https://www.readbyqxmd.com/read/28196848/gps-based-exposure-to-greenness-and-walkability-and-accelerometry-based-physical-activity
#12
Peter James, Jaime E Hart, J Aaron Hipp, Jonathan Mitchell, Jacqueline Kerr, Philip M Hurvitz, Karen Glanz, Francine Laden
BACKGROUND: Physical inactivity is a risk factor for cancer that may be influenced by environmental factors. Indeed, dense and well-connected built environments and environments with natural vegetation may create opportunities for higher routine physical activity. However, studies have focused primarily on residential environments to define exposure and self-reported methods to estimate physical activity. The current study explores the momentary association between minute-level global positioning systems (GPS)-based greenness exposure and time-matched objectively measured physical activity...
February 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28195161/gas-chromatography-mass-spectrometry-analysis-of-effects-of-dietary-fish-oil-on-total-fatty-acid-composition-in-mouse-skin
#13
Peiru Wang, Min Sun, Jianwei Ren, Zora Djuric, Gary J Fisher, Xiuli Wang, Yong Li
Altering the fatty acid (FA) composition in the skin by dietary fish oil could provide therapeutic benefits. Although it has been shown that fish oil supplementation enhances EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) abundance in the skin, comprehensive skin FA profiling is needed. We established a gas chromatography-mass spectrometry method, which allows precise quantification of FA profile using small (<24 mm(2) for mice and <12 mm(2) for humans) skin specimens that can be readily obtained from live mice and humans...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194404/a-note-on-fatty-acids-profile-of-meat-from-broiler-chickens-supplemented-with-inorganic-or-organic-selenium
#14
Marta Del Puerto, M Cristina Cabrera, Ali Saadoun
This investigation evaluated, in broiler chickens Pectoralis and Gastrocnemius muscles, the effect of the dietary supplementation with sodium selenite (0.3 ppm) versus selenomethionine (0.3 ppm), on the fatty acids composition, lipids indices, and enzymes indexes for desaturase, elongase, and thioesterase. The selenium reduced, in both muscles, the content of atherogenic fatty acids, C14:0 and C16:0, while it increased the C18:1 level. On the other hand, selenium increased, in both muscles, the content of C18:3n3 and EPA, but not DPA and DHA...
2017: International journal of food science
https://www.readbyqxmd.com/read/28193789/enriching-islet-phospholipids-with-eicosapentaenoic-acid-reduces-prostaglandin-e2-signaling-and-enhances-diabetic-%C3%AE-cell-function
#15
Joshua C Neuman, Michael D Schaid, Allison L Brill, Rachel J Fenske, Carly R Kibbe, Danielle A Fontaine, Sophia M Sdao, Harpreet K Brar, Kelsey M Connors, Haley N Wienkes, Kevin W Eliceiri, Matthew J Merrins, Dawn B Davis, Michelle E Kimple
Prostaglandin E2 (PGE2) is derived from arachidonic acid, while PGE3 is derived from eicosapentaenoic acid (EPA) using the same downstream metabolic enzymes. Little is known about the impact of EPA and PGE3 on β-cell function, particularly in the diabetic state. In this work, we determined PGE3 elicits a 10-fold weaker reduction in glucose-stimulated insulin secretion through the EP3 receptor as compared to PGE2 We tested the hypothesis that enriching pancreatic islet cell membranes with EPA, thereby reducing arachidonic acid abundance, would positively impact β-cell function in the diabetic state...
February 13, 2017: Diabetes
https://www.readbyqxmd.com/read/28192767/editorial-the-epa-brexit-and-beyond
#16
EDITORIAL
J Beezhold, W Gaebel, S Galderisi, P Gorwood, M Martín Carrasco, D Wasserman
No abstract text is available yet for this article.
December 20, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28192766/epa-position-paper-improving-the-image-of-psychiatry-and-psychiatrists
#17
EDITORIAL
J Beezhold, W Gaebel, S Galderisi, P Gorwood, M Martin-Carrasco, D Wasserman
No abstract text is available yet for this article.
December 20, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28192538/pattern-of-omega-3-polyunsaturated-fatty-acid-intake-and-fish-consumption-and-retinal-vascular-caliber-in-children-and-adolescents-a-cohort-study
#18
Bamini Gopinath, Hanieh Moshtaghian, Victoria M Flood, Jimmy C Y Louie, Gerald Liew, George Burlutsky, Paul Mitchell
We aimed to investigate whether fish and long chain omega-3 polyunsaturated fatty acid (LCn-3 PUFA) consumption changed appreciably during adolescence. We also assessed whether these dietary variables are associated with retinal microvascular signs (possible markers of future cardiovascular disease risk). 633 children had dietary data at ages 12 and 17. Fish and LCn-3 PUFA [eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA)] intake was assessed by a food frequency questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28191333/effects-of-fish-oil-supplementation-on-gestational-diabetes-mellitus-gdm-a-systematic-review
#19
REVIEW
Alireza Ostadrahimi, Sakineh Mohammad-Alizadeh, Mozhgan Mirgafourvand, Sina Yaghoubi, Elham Shahrisa, Azizeh Farshbaf-Khalili
CONTEXT: One of the most common complications of pregnancy is gestational diabetes mellitus (GDM), which is increasing worldwide. Experimental and epidemiological studies have shown that higher intake of n-3 long-chain polyunsaturated fatty acids may decrease the risk of various diseases such as diabetes. The objective of this study was to assess the effect of fish oil supplementation on the prevention and treatment of GDM. EVIDENCE ACQUISITION: This systematic review was performed by searching several databases, including PubMed, Scopus, Google Scholar, the Cochrane Library, ProQuest, Science Direct SID, Magiran and IranMedex since 1983...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28189115/n-3-polyunsaturated-fatty-acids-alleviate-high-glucose-mediated-dysfunction-of-endothelial-progenitor-cells-and-prevent-ischemic-injuries-both-in-vitro-and-in-vivo
#20
Shao-Chih Chiu, Che-Yi Chao, En-Pei Isabel Chiang, Jia-Ning Syu, Raymond L Rodriguez, Feng-Yao Tang
Hyperglycemia is associated with a reduced number of endothelial progenitor cells (EPCs) that impairs vascular function. Circulating EPCs play important roles in postnatal neovasculogenesis and the prevention of ischemic injury. Frequent consumption of fish oil (FO) that is abundant with eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) is reportedly associated with an alleviation of diabetic complications and a lowered incidence of cardiovascular disease. The aim of this study was to examine whether N-3 polyunsaturated fatty acids such as EPA and DHA would reverse the high glucose-mediated dysfunction of EPCs in vitro and thereby prevent the ischemic injury that occurs under the hyperglycemic conditions in Type 2 diabetes (T2D) db(-/-) mice...
January 28, 2017: Journal of Nutritional Biochemistry
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