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plasmodium vivax malaria

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https://www.readbyqxmd.com/read/28637467/imported-plasmodium-falciparum-and-locally-transmitted-plasmodium-vivax-cross-border-malaria-transmission-scenario-in-northwestern-thailand
#1
Patchara Sriwichai, Stephan Karl, Yudthana Samung, Kirakorn Kiattibutr, Jeeraphat Sirichaisinthop, Ivo Mueller, Liwang Cui, Jetsumon Sattabongkot
BACKGROUND: Cross-border malaria transmission is an important problem for national malaria control programmes. The epidemiology of cross-border malaria is further complicated in areas where Plasmodium falciparum and Plasmodium vivax are both endemic. By combining passive case detection data with entomological data, a transmission scenario on the northwestern Thai-Myanmar border where P. falciparum is likely driven by importation was described, whereas P. vivax is also locally transmitted...
June 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28630585/identification-of-the-plasmodium-species-in-clinical-samples-from-children-residing-in-five-epidemiological-strata-of-malaria-in-cameroon
#2
Tebit Emmanuel Kwenti, Tayong Dizzle Bita Kwenti, Longdoh Anna Njunda, Andreas Latz, Kukwah Anthony Tufon, Theresa Nkuo-Akenji
BACKGROUND: Malaria in Cameroon was previously known to be caused solely by Plasmodium falciparum but today, evidence points to other Plasmodium species including P. vivax, P. ovale and P. malariae. The purpose of this study was to identify the Plasmodium species in clinical samples from children residing in five epidemiological strata of malaria in Cameroon, so as to advise control policies. METHODS: One thousand six hundred nine febrile children (≤15 years) were recruited from five epidemiological strata of malaria including the Sudano-sahelian (SS) strata, the High inland plateau (HIP) strata, the South Cameroonian Equatorial forest (SCEF) strata, the High western plateau (HWP) strata and the Coastal (C) strata...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28626547/structure-guided-optimization-of-quinoline-inhibitors-of-plasmodium-n-myristoyltransferase
#3
Victor Goncalves, James A Brannigan, Alice Laporte, Andrew S Bell, Shirley M Roberts, Anthony J Wilkinson, Robin J Leatherbarrow, Edward W Tate
The parasite Plasmodium vivax is the most widely distributed cause of recurring malaria. N-Myristoyltransferase (NMT), an enzyme that catalyses the covalent attachment of myristate to the N-terminal glycine of substrate proteins, has been described as a potential target for the treatment of this disease. Herein, we report the synthesis and the structure-guided optimization of a series of quinolines with balanced activity against both Plasmodium vivax and Plasmodium falciparum N-myristoyltransferase (NMT).
January 1, 2017: MedChemComm
https://www.readbyqxmd.com/read/28626211/once-malaria-is-eliminated-more-attention-should-be-paid-to-imported-malaria-data-from-five-years-of-surveillance-in-the-city-of-yiwu-in-eastern-china
#4
Xuanjun Dong, Jie Yang, Lianqin Lou, Liebo Zhu, Xiayan Feng, Linong Yao
This study reviewed and analyzed data on malaria cases in Yiwu from 2012 to 2016 via a webbased system for managing and reporting information on infectious diseases. A total of 161 cases were diagnosed (77.02% due to Plasmodium falciparum, 18.01% due to P. vivax, 4.35% due to P. ovale, and 0.62% due to P. malariae). One case was imported from Yunnan Province in China and the others were imported from overseas. The ratio of male to female patients was 7.47:1. The average age was 36.34 years (SD: 9.63). Most cases (87...
June 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28619120/g6pd-deficiency-alleles-in-a-malaria-endemic-region-in-the-western-brazilian-amazon
#5
Jamille G Dombrowski, Rodrigo M Souza, Jonathan Curry, Laura Hinton, Natercia R M Silva, Lynn Grignard, Ligia A Gonçalves, Ana Rita Gomes, Sabrina Epiphanio, Chris Drakeley, Jim Huggett, Taane G Clark, Susana Campino, Claudio R F Marinho
BACKGROUND: Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. Infected individuals are treated with primaquine, which can induce haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals and may lead to severe and fatal complications. This X-linked disorder is distributed globally and is caused by allelic variants with a geographical distribution that closely reflects populations exposed historically to endemic malaria...
June 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28616358/parkinsonism-and-tremor-in-a-patient-with-plasmodium-vivax-malaria
#6
Jung E Park
BACKGROUND: A 57-year-old male diagnosed with Plasmodium vivax malaria presented with a subacute onset of hand tremor, slowness, and gait difficulty. PHENOMENOLOGY: A bilateral upper extremity kinetic tremor was seen, as well as a right upper extremity rigidity and body bradykinesia. EDUCATIONAL VALUE: Parkinsonism and tremor are neurological manifestations that may occur in malaria as a result of globus pallidi and dentate nuclei involvement...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28614791/human-vaccination-against-plasmodium-vivax-duffy-binding-protein-induces-strain-transcending-antibodies
#7
Ruth O Payne, Sarah E Silk, Sean C Elias, Kathryn H Milne, Thomas A Rawlinson, David Llewellyn, A Rushdi Shakri, Jing Jin, Geneviève M Labbé, Nick J Edwards, Ian D Poulton, Rachel Roberts, Ryan Farid, Thomas Jørgensen, Daniel Gw Alanine, Simone C de Cassan, Matthew K Higgins, Thomas D Otto, James S McCarthy, Willem A de Jongh, Alfredo Nicosia, Sarah Moyle, Adrian Vs Hill, Eleanor Berrie, Chetan E Chitnis, Alison M Lawrie, Simon J Draper
BACKGROUND: Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vaccination...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28604825/burden-and-impact-of-plasmodium-vivax-in-pregnancy-a-multi-centre-prospective-observational-study
#8
Azucena Bardají, Flor Ernestina Martínez-Espinosa, Myriam Arévalo-Herrera, Norma Padilla, Swati Kochar, Maria Ome-Kaius, Camila Bôtto-Menezes, María Eugenia Castellanos, Dhanpat Kumar Kochar, Sanjay Kumar Kochar, Inoni Betuela, Ivo Mueller, Stephen Rogerson, Chetan Chitnis, Dhiraj Hans, Michela Menegon, Carlo Severini, Hernando Del Portillo, Carlota Dobaño, Alfredo Mayor, Jaume Ordi, Mireia Piqueras, Sergi Sanz, Mats Wahlgren, Laurence Slutsker, Meghna Desai, Clara Menéndez
BACKGROUND: Despite that over 90 million pregnancies are at risk of Plasmodium vivax infection annually, little is known about the epidemiology and impact of the infection in pregnancy. METHODOLOGY AND PRINCIPAL FINDINGS: We undertook a health facility-based prospective observational study in pregnant women from Guatemala (GT), Colombia (CO), Brazil (BR), India (IN) and Papua New Guinea PNG). Malaria and anemia were determined during pregnancy and fetal outcomes assessed at delivery...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28600217/limited-genetic-diversity-in-the-global-plasmodium-vivax-cell-traversal-protein-of-ookinetes-and-sporozoites-celtos-sequences-implications-for-pvceltos-based-vaccine-development
#9
Akram Abouie Mehrizi, Fatemeh Torabi, Sedigheh Zakeri, Navid Dinparast Djadid
Cell traversal protein of Ookinetes and Sporozoites (CelTOS) is a new malaria vaccine candidate antigen. Since one of the main challenges in malaria vaccine development is the extensive antigenic diversity of this parasite, local and global gene diversity analysis is of particular importance. Therefore, in this study, the genetic diversity of pvceltos gene was investigated among Iranian P. vivax isolates (n=46) and compared with available worldwide pvceltos sequences. One synonymous (C109A) and three amino acid replacements (V118L, K178T, and G179R) were observed in Iranian pvceltos sequences in compare with Sal-1 sequence leading to five haplotypes including PvCelt-A (GSVKGL, 13%), PvCelt-B (GSLKGL, 50%), PvCelt-C (GSLTGL, 17...
June 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28595603/current-and-cumulative-malaria-infections-in-a-setting-embarking-on-elimination-amhara-ethiopia
#10
Woyneshet G Yalew, Sampa Pal, Pooja Bansil, Rebecca Dabbs, Kevin Tetteh, Caterina Guinovart, Michael Kalnoky, Belendia A Serda, Berhane H Tesfay, Belay B Beyene, Catherine Seneviratne, Megan Littrell, Lindsay Yokobe, Gregory S Noland, Gonzalo J Domingo, Asefaw Getachew, Chris Drakeley, Richard W Steketee
BACKGROUND: Since 2005, Ethiopia has aggressively scaled up malaria prevention and case management. As a result, the number of malaria cases and deaths has significantly declined. In order to track progress towards the elimination of malaria in Amhara Region, coverage of malaria control tools and current malaria transmission need to be documented. METHODS: A cross-sectional household survey oversampling children under 5 years of age was conducted during the dry season in 2013...
June 8, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28591790/asian-g6pd-mahidol-reticulocytes-sustain-normal-plasmodium-vivax-development
#11
Germana Bancone, Benoit Malleret, Rossarin Suwanarusk, Nongnud Chowwiwat, Cindy S Chu, Rose McGready, Laurent Rénia, François Nosten, Bruce Russell
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in humans and appears to be protective against falciparum severe malaria. Controversially, it is also thought that Plasmodium vivax has driven the recent selection of G6PD alleles. We use an experimental approach to determine whether G6PD-MahidolG487A variant, a widespread cause of severe G6PD deficiency in Southeast Asia, provides a barrier against vivax malaria. Our results show that the immature reticulocytes (CD71+) targeted by P...
June 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28587615/genome-wide-scans-for-the-identification-of-plasmodium-vivax-genes-under-positive-selection
#12
Hai-Mo Shen, Shen-Bo Chen, Yue Wang, Bin Xu, Eniola Michael Abe, Jun-Hu Chen
BACKGROUND: The current trend of Plasmodium vivax cases imported from Southeast Asia into China has sharply increased recently, especially from the China-Myanmar border (CMB) area. High recombination rates of P. vivax populations associated with varied transmission intensity might cause distinct local selective pressures. The information on the genetic variability of P. vivax in this area is scant. Hence, this study assessed the genetic diversity of P. vivax genome sequence in CMB area and aimed to provide information on the positive selection of new gene loci...
June 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28583133/comparative-physical-genome-mapping-of-malaria-vectors-anopheles-sinensis-and-anopheles-gambiae
#13
Yun Wei, Biao Cheng, Guoding Zhu, Danyu Shen, Jiangtao Liang, Cong Wang, Jing Wang, Jianxia Tang, Jun Cao, Igor V Sharakhov, Ai Xia
BACKGROUND: Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. RESULTS: Here, a physical genome map for An...
June 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28571216/plasmodium-vivax-induced-acute-respiratory-distress-syndrome-a-diagnostic-and-therapeutic-dilemma-in-preeclampsia
#14
Richa Sharma, Amita Suneja, Anu Yadav, Kiran Guleria
Malaria during pregnancy can cause various feto-maternal complications. Life threatening respiratory involvement is rare with vivax malaria but common with Plasmodium falciparum. In most of the cases severe respiratory involvement occurs, after beginning of anti-malarial treatment. We are reporting a case which involved a diagnostic and therapeutic challenge, as the pregnant woman with severe preeclampsia developed acute respiratory distress, actually caused by Plasmodium vivax.
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28571194/bilateral-cervical-lymphadenopathy-atypical-presentation-of-malaria-a-rare-case-report
#15
Dwijen Das, Kallol Bhattacharjee, Surinder Ghintala, Amit Kr Kalwar
Malaria, the most common parasitic disease of humans, remains a major health and economic burden in most tropical countries. An 18-year-old male from rural north eastern India presented with four days fever with chill. The patient was conscious, oriented but confused. Physical examination revealed bilateral multiple, discrete cervical lymphadenitis without organomegaly or sternal tenderness. Blood parameters were normal except transient thrombocytopenia. Blood smear and antigen were positive for both Plasmodium vivax and falciparum with negative viral markers...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569159/fast-and-robust-single-pcr-for-plasmodium-sporozoite-detection-in-mosquitoes-using-the-cytochrome-oxidase-i-gene
#16
Diego F Echeverry, Nicholas A Deason, Victoria Makuru, Jenna Davidson, Honglin Xiao, Julie Niedbalski, Xiaoyu Yu, Jennifer C Stevenson, Hugo Bugoro, Allan Aparaimo, Hedrick Reuben, Robert Cooper, Thomas R Burkot, Tanya L Russell, Frank H Collins, Neil F Lobo
BACKGROUND: Molecular tools for detecting malaria-infected mosquitoes with improved practicality, sensitivity and specificity, and high-throughput are required. A common PCR technique used to detect mosquitoes infected with Plasmodium spp. is a nested PCR assay based on the 18s-rRNA gene. However, this technique has several technical limitations, is laborious and time consuming. METHODS: In this study, a PCR-based on the Plasmodium cytochrome oxidase I (COX-I) gene was compared with the 18s-rRNA nested PCR using serial dilutions (330-0...
May 31, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28558764/elimination-of-plasmodium-falciparum-malaria-in-tajikistan
#17
Anatoly V Kondrashin, Azizullo S Sharipov, Dilshod S Kadamov, Saifuddin S Karimov, Elkhan Gasimov, Alla M Baranova, Lola F Morozova, Ekaterina V Stepanova, Natalia A Turbabina, Maria S Maksimova, Evgeny N Morozov
Malaria was eliminated in Tajikistan by the beginning of the 1960s. However, sporadic introduced cases of malaria occurred subsequently probably as a result of transmission from infected mosquito Anopheles flying over river the Punj from the border areas of Afghanistan. During the 1970s and 1980s local outbreaks of malaria were reported in the southern districts bordering Afghanistan. The malaria situation dramatically changed during the 1990s following armed conflict and civil unrest in the newly independent Tajikistan, which paralyzed health services including the malaria control activities and a large-scale malaria epidemic occurred with more than 400,000 malaria cases...
May 30, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28549910/naturally-acquired-immune-responses-to-thrombospondin-related-adhesion-protein-trap-of-plasmodium-vivax-in-patients-from-areas-of-unstable-malaria-transmission
#18
Saeed Nazeri, Sedigheh Zakeri, Akram Abouie Mehrizi, Navid Dinparast Djadid
A key tool for the control, elimination, and eradication of Plasmodium vivax is the development of an effective vaccine. The thrombospondin-related adhesion protein (TRAP) is one of the major sporozoite antigens that plays an important role in the invasion of mosquito salivary glands and hepatocytes by sporozoites. The main goal of this study was to evaluate the naturally acquired antibodies to the P. vivax TRAP (PvTRAP) in patients from malaria-endemic areas of Iran (n=116), Afghanistan (n=50), and Pakistan (n=50)...
May 23, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28542194/using-g6pd-tests-to-enable-the-safe-treatment-of-plasmodium-vivax-infections-with-primaquine-on-the-thailand-myanmar-border-a-cost-effectiveness-analysis
#19
Angela Devine, Minnie Parmiter, Cindy S Chu, Germana Bancone, François Nosten, Ric N Price, Yoel Lubell, Shunmay Yeung
BACKGROUND: Primaquine is the only licensed antimalarial for the radical cure of Plasmodium vivax infections. Many countries, however, do not administer primaquine due to fear of hemolysis in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In other settings, primaquine is given without G6PD testing, putting patients at risk of hemolysis. New rapid diagnostic tests (RDTs) offer the opportunity to screen for G6PD deficiency prior to treatment with primaquine. Here we assessed the cost-effectiveness of using G6PD RDTs on the Thailand-Myanmar border and provide the model as an online tool for use in other settings...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28542123/malaria-surveillance-united-states-2014
#20
Kimberly E Mace, Paul M Arguin
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
May 26, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
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