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plasmodium vivax malaria

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https://www.readbyqxmd.com/read/28427455/comparison-of-methods-for-detecting-asymptomatic-malaria-infections-in-the-china-myanmar-border-area
#1
Yonghong Zhao, Yan Zhao, Yanmin Lv, Fei Liu, Qinghui Wang, Peipei Li, Zhenjun Zhao, Yingjie Liu, Liwang Cui, Qi Fan, Yaming Cao
BACKGROUND: Sensitive methods for detecting asymptomatic malaria infections are essential for identifying potential transmission reservoirs and obtaining an accurate assessment of malaria epidemiology in low-endemicity areas aiming to eliminate malaria. PCR techniques to detect parasite nucleic acids (DNA or RNA) are among the most commonly used molecular methods. However, most of these methods are of low throughput and cannot be used for large-scale molecular epidemiological studies...
April 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28427451/household-level-spatio-temporal-analysis-of-plasmodium-falciparum-and-plasmodium-vivax-malaria-in-ethiopia
#2
Dinberu Seyoum, Delenasaw Yewhalaw, Luc Duchateau, Patrick Brandt, Angel Rosas-Aguirre, Niko Speybroeck
BACKGROUND: The global decline of malaria burden and goals for elimination has led to an increased interest in the fine-scale epidemiology of malaria. Micro-geographic heterogeneity of malaria infection could have implications for designing targeted small-area interventions. METHODS: Two-year longitudinal cohort study data were used to explore the spatial and spatio-temporal distribution of malaria episodes in 2040 children aged < 10 years in 16 villages near the Gilgel-Gibe hydropower dam in Southwest Ethiopia...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28423028/four-human-plasmodium-species-quantification-using-droplet-digital-pcr
#3
Suttipat Srisutham, Naowarat Saralamba, Benoit Malleret, Laurent Rénia, Arjen M Dondorp, Mallika Imwong
Droplet digital polymerase chain reaction (ddPCR) is a partial PCR based on water-oil emulsion droplet technology. It is a highly sensitive method for detecting and delineating minor alleles from complex backgrounds and provides absolute quantification of DNA targets. The ddPCR technology has been applied for detection of many pathogens. Here the sensitive assay utilizing ddPCR for detection and quantification of Plasmodium species was investigated. The assay was developed for two levels of detection, genus specific for all Plasmodium species and for specific Plasmodium species detection...
2017: PloS One
https://www.readbyqxmd.com/read/28421327/metal-dna-interactions-improve-signal-in-high-resolution-melting-of-dna-for-species-differentiation-of-plasmodium-parasite
#4
Priyamvada Jain, Babina Chakma, Naveen Singh, Sanjukta Patra, Pranab Goswami
The success of high-resolution melting (HRM) analysis for distinguishing similar DNAs with minor base mismatch differences is limited. Here, metal-mediated structural change in DNA has been exploited to amplify HRM signals leading to differentiation of target DNAs in an orthologous gene corresponding to four Plasmodium species. Conserved 26-mer ssDNAs from ldh gene of the four Plasmodium species were employed as targets. A capture probe (CP) that is fully complementary to the Plasmodium falciparum target (FT) and has two base mismatches each, with the targets of Plasmodium vivax (VT), Plasmodium malariae, (MT), and Plasmodium ovale (OT), was considered...
April 18, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28420389/assessment-of-copy-number-variation-in-genes-related-to-drug-resistance-in-plasmodium-vivax-and-plasmodium-falciparum-isolates-from-the-brazilian-amazon-and-a-systematic-review-of-the-literature
#5
Gabriel Luíz Costa, Lara Cotta Amaral, Cor Jesus Fernandes Fontes, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito, Taís Nóbrega de Sousa
BACKGROUND: Parasite resistance to anti-malarials represents a great obstacle for malaria elimination. The majority of studies have investigated the association between single-nucleotide polymorphisms (SNPs) and drug resistance; however, it is becoming clear that the copy number variation (CNV) is also associated with this parasite phenotype. To provide a baseline for molecular surveillance of anti-malarial drug resistance in the Brazilian Amazon, the present study characterized the genetic profile of both markers in the most common genes associated with drug resistance in Plasmodium falciparum and Plasmodium vivax isolates...
April 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28417968/rational-development-of-a-protective-p-vivax-vaccine-evaluated-with-transgenic-rodent-parasite-challenge-models
#6
Ahmed M Salman, Eduardo Montoya-Díaz, Heather West, Amar Lall, Erwan Atcheson, Cesar Lopez-Camacho, Jai Ramesar, Karolis Bauza, Katharine A Collins, Florian Brod, Fernando Reis, Leontios Pappas, Lilia González-Cerón, Chris J Janse, Adrian V S Hill, Shahid M Khan, Arturo Reyes-Sandoval
Development of a protective and broadly-acting vaccine against the most widely distributed human malaria parasite, Plasmodium vivax, will be a major step towards malaria elimination. However, a P. vivax vaccine has remained elusive by the scarcity of pre-clinical models to test protective efficacy and support further clinical trials. In this study, we report the development of a highly protective CSP-based P. vivax vaccine, a virus-like particle (VLP) known as Rv21, able to provide 100% sterile protection against a stringent sporozoite challenge in rodent models to malaria, where IgG2a antibodies were associated with protection in absence of detectable PvCSP-specific T cell responses...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417346/-role-of-primaquine-in-malaria-control-and-elimination-in-french-speaking-africa
#7
S Briolant, B Pradines, L K Basco
Primaquine, an 8-aminoquinoline, is a relatively unknown and underutilized drug in French-speaking African countries. It acts against the liver stage parasites of all human malaria species, asexual blood stages of Plasmodium vivax and, to a lesser degree, Plasmodium falciparum; P. falciparum mature gametocytes, and P. vivax and Plasmodium ovale hypnozoites. Gastrointestinal disturbances are its most common side effects. The clinical utility of primaquine is limited due to its hematological side effects in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency and other contraindications (pregnant woman, breastfeeding woman, infants less than 6 months old)...
April 17, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28414070/the-unhealthy-attraction-of-plasmodium-vivax-to-reticulocytes-expressing-transferrin-receptor-1-cd71
#8
REVIEW
Benoit Malleret, Laurent Rénia, Bruce Russell
The majority of malaria parasite species prefer to invade reticulocytes, the most infamous being Plasmodium vivax. While the absence of an in vitro continuous culture method has hampered the study of P. vivax invasion biology, studies utilising primate models and ex vivo assays have provided some important insights. Most importantly, P. vivax merozoites have a strong preference for a subset of immature erythrocytes characterised by the expression of the transferrin receptor (CD71). This current opinion piece on P...
April 13, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28410610/an-intricate-case-of-multidrug-resistant-plasmodium-falciparum-isolate-imported-from-cambodia
#9
Raffaele Dell'Acqua, Claudia Fabrizio, Francesco Di Gennaro, Sergio Lo Caputo, Annalisa Saracino, Michela Menegon, Mariangela L'Episcopia, Carlo Severini, Laura Monno, Francesco Castelli, Gioacchino Angarano
BACKGROUND: Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementation of health prevention measures. CASE REPORT: A complex case of imported malaria caused by Plasmodium vivax/P. falciparum isolates in a patient who was not taking chemoprophylaxis while he was travelling in Cambodia is reported in this article...
April 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28406404/risk-of-daytime-transmission-of-malaria-in-the-french-guiana-rain-forest
#10
V Pommier de Santi, I Dusfour, E de Parseval, B Lespinet, C Nguyen, P Gaborit, R Carinci, G Hyvert, R Girod, S Briolant
Between 2008 and 2014, there were 1070 malaria cases reported in French Guiana among members of the armed forces. Most of the malaria outbreaks investigated were multifactorial and followed missions conducted at illegal gold mining sites. For example, a malaria outbreak occurred in September 2013, three weeks after the deployment of 15 soldiers at Dagobert, which is such a site. The attack rate was 53%, with seven Plasmodium vivax infections and one coinfection with both Plasmodium vivax and Plasmodium falciparum...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28384192/plasmodium-vivax-gametocytes-in-the-bone-marrow-of-an-acute-malaria-patient-and-changes-in-the-erythroid-mirna-profile
#11
Barbara Baro, Katrien Deroost, Tainá Raiol, Marcelo Brito, Anne C G Almeida, Armando de Menezes-Neto, Erick F G Figueiredo, Aline Alencar, Rodrigo Leitão, Fernando Val, Wuelton Monteiro, Anna Oliveira, Maria Del Pilar Armengol, Carmen Fernández-Becerra, Marcus V Lacerda, Hernando A Del Portillo
No abstract text is available yet for this article.
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28381261/challenges-for-achieving-safe-and-effective-radical-cure-of-plasmodium-vivax-a-round-table-discussion-of-the-apmen-vivax-working-group
#12
Kamala Thriemer, Benedikt Ley, Albino Bobogare, Lek Dysoley, Mohammad Shafiul Alam, Ayodhia P Pasaribu, Jetsumon Sattabongkot, Elodie Jambert, Gonzalo J Domingo, Robert Commons, Sarah Auburn, Jutta Marfurt, Angela Devine, Mohammad M Aktaruzzaman, Nayeem Sohel, Rinzin Namgay, Tobgyel Drukpa, Surender Nath Sharma, Elvieda Sarawati, Iriani Samad, Minerva Theodora, Simone Nambanya, Sonesay Ounekham, Rose Nanti Binti Mudin, Garib Da Thakur, Leo Sora Makita, Raffy Deray, Sang-Eun Lee, Leonard Boaz, Manjula N Danansuriya, Santha D Mudiyanselage, Nipon Chinanonwait, Suravadee Kitchakarn, Johnny Nausien, Esau Naket, Thang Ngo Duc, Ha Do Manh, Young S Hong, Qin Cheng, Jack S Richards, Rita Kusriastuti, Ari Satyagraha, Rintis Noviyanti, Xavier C Ding, Wasif Ali Khan, Ching Swe Phru, Zhu Guoding, Gao Qi, Akira Kaneko, Olivo Miotto, Wang Nguitragool, Wanlapa Roobsoong, Katherine Battle, Rosalind E Howes, Arantxa Roca-Feltrer, Stephan Duparc, Ipsita Pal Bhowmick, Enny Kenangalem, Jo-Anne Bibit, Alyssa Barry, David Sintasath, Rabindra Abeyasinghe, Carol H Sibley, James McCarthy, Lorenz von Seidlein, J Kevin Baird, Ric N Price
The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia-Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discussion was held to discuss the programmatic issues hindering the widespread use of primaquine (PQ) radical cure. Participants included 73 representatives from 16 partner countries and 33 institutional partners and other research institutes...
April 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28379500/naturally-acquired-human-antibodies%C3%A2-against-reticulocyte-binding-domains-of-plasmodium-vivax-proteins-pvrbp2c-and-pvrbp1a-exhibit-binding%C3%A2-inhibitory-activity
#13
Enna Dogra Gupta, Gaurav Anand, Hina Singh, Kritika Chaddha, Praveen K Bharti, Neeru Singh, Yagya Dutta Sharma, Deepak Gaur
Background: Crucial gaps in our understanding of P. vivax reticulocyte invasion and protective immunity have hampered development of vivax vaccines. P. vivax exclusively invades reticulocytes that is mediated by the P. vivax reticulocyte binding proteins (PvRBPs) specifically PvRBP2c and PvRBP1a. Vivax infections in Duffy-null individuals have suggested the evolution of alternate invasion pathways that may be mediated by the PvRBPs. Thus, PvRBPs appear as potential targets for efficacious P...
April 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28376883/asymptomatic-and-sub-microscopic-malaria-infection-in-kayah-state-eastern-myanmar
#14
Myo Thiha Zaw, Myo Thant, Tin Maung Hlaing, Naing Zin Aung, Min Thu, Kanit Phumchuea, Kanokwan Phusri, Teerawat Saeseu, Ritthideach Yorsaeng, Wang Nguitragool, Ingrid Felger, Jaranit Kaewkungwal, Liwang Cui, Jetsumon Sattabongkot
BACKGROUND: Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must be targeted for malaria elimination. METHODS: A mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light microscopy and real-time polymerase chain reaction (PCR), and its association with demographic factors was explored...
April 4, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28369085/defining-the-next-generation-of-plasmodium-vivax-diagnostic-tests-for-control-and-elimination-target-product-profiles
#15
Xavier C Ding, Maria Paz Ade, J Kevin Baird, Qin Cheng, Jane Cunningham, Mehul Dhorda, Chris Drakeley, Ingrid Felger, Dionicia Gamboa, Matthias Harbers, Socrates Herrera, Naomi Lucchi, Alfredo Mayor, Ivo Mueller, Jetsumon Sattabongkot, Arsène Ratsimbason, Jack Richards, Marcel Tanner, Iveth J González
The global prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical attacks without involving another mosquito bite. The diagnosis of acute patent P. vivax malaria relies primarily on light microscopy...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28367735/severe-vivax-malaria-a-prospective-exploration-at-a-tertiary-healthcare-centre-in-southwestern-india
#16
Rishikesh Kumar, Kavitha Saravu
Plasmodium vivax is recognized to cause severe malaria and mortality. We aimed to determine the proportion of disease severity, the spectrum of complications, underlying non-infectious comorbidities and predictors of severity in monoinfection P. vivax malaria among adults at a tertiary healthcare centre in Southwestern India. A prospective cohort study was conducted among microscopically confirmed monoinfection P. vivax acute malaria patients aged, ≥18 years. Cases with pregnancy and concomitant febrile illnesses including mixed malaria were excluded...
April 3, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28366603/malaria-eradication-and-the-hidden-parasite-reservoir
#17
Miles B Markus
Accumulation of erythrocytic parasites in bone marrow and the spleen has been reported in cases of Plasmodium vivax malaria. If this occurs commonly, these stages represent a possible source of early, relapse-like homologous recurrences. Moreover, they might hinder the elimination of malaria from human populations. Pertinent research suggestions have been made.
March 30, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28359340/world-malaria-report-time-to-acknowledge-plasmodium-knowlesi-malaria
#18
Bridget E Barber, Giri S Rajahram, Matthew J Grigg, Timothy William, Nicholas M Anstey
BACKGROUND: The 2016 World Health Organization (WHO) World Malaria Report documents substantial progress towards control and elimination of malaria. However, major challenges remain. In some regions of Southeast Asia, the simian parasite Plasmodium knowlesi has emerged as an important cause of human malaria, and the authors believe this species warrants regular inclusion in the World Malaria Report. MAIN TEXT: Plasmodium knowlesi is the most common cause of malaria in Malaysia, and cases have also been reported in nearly all countries of Southeast Asia...
March 31, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28357581/malaria-an-update
#19
REVIEW
Srikanta Basu, Puneet Kaur Sahi
India is endemic for malaria with unstable transmission inhibiting the development of immunity and predisposing all age groups to the disease. Children under five are the greatest sufferers with maximum mortality. P. falciparum and P. vivax cause majority of cases. Fever is the cardinal symptom, though no set of signs and symptoms reliably distinguishes malaria from other causes of fever. In all suspected cases parasitological diagnosis should be confirmed before starting the treatment. Microscopy of blood smears is the gold standard for diagnosis...
March 30, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28352046/evaluation-of-sybr-green-i-based-visual-loop-mediated-isothermal-amplification-lamp-assay-for-genus-and-species-specific-diagnosis-of-malaria-in-p-vivax-and-p-falciparum-endemic-regions
#20
COMPARATIVE STUDY
Ruchi Singh, Dhirendra Pratap Singh, Deepali Savargaonkar, Om P Singh, Rajendra M Bhatt, Neena Valecha
BACKGROUND & OBJECTIVES: Loop-mediated isothermal amplification (LAMP) is an emerging nucleic acid based diag- nostic approach that is easily adaptable to the field settings with limited technical resources. This study was aimed to evaluate the LAMP assay for the detection and identification of Plasmodium falciparum and P. vivax infection in malaria suspected cases using genus and species-specific assay. METHODS: The 18S rRNA-based LAMP assay was evaluated for diagnosis of genus Plasmodium, and species- specific diagnosis of P...
January 2017: Journal of Vector Borne Diseases
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