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plasmodium vivax malaria

Benjamin C Lin, Darcy R Harris, Lucy M D Kirkman, Astrid M Perez, Yiwen Qian, Janse T Schermerhorn, Min Y Hong, Dennis S Winston, Lingyin Xu, Gabriel S Brandt
A relatively high-affinity inhibitor of FIKK kinase from the malaria parasite Plasmodium vivax was identified by in vitro assay of recombinant kinase. The FIKK kinase family is unique to parasitic organisms of the Apicomplexan order and has been shown to be critical in malaria parasites. The recombinant kinase domain was expressed and screened against a small molecule library, revealing a number of tyrosine kinase inhibitors that block FIKK kinase activity. A family of tyrphostins was further investigated, to begin exploring the FIKK kinase pharmacophore...
October 31, 2017: ACS Omega
Gabriela Arévalo-Pinzón, María González-González, Carlos Fernando Suárez, Hernando Curtidor, Javier Carabias-Sánchez, Antonio Muro, Joshua LaBaer, Manuel Alfonso Patarroyo, Manuel Fuentes
BACKGROUND: Plasmodium vivax is the most widespread malarial species, causing significant morbidity worldwide. Knowledge is limited regarding the molecular mechanism of invasion due to the lack of a continuous in vitro culture system for these species. Since protein-protein and host-cell interactions play an essential role in the microorganism's invasion and replication, elucidating protein function during invasion is critical when developing more effective control methods. Nucleic acid programmable protein array (NAPPA) has thus become a suitable technology for studying protein-protein and host-protein interactions since producing proteins through the in vitro transcription/translation (IVTT) method overcomes most of the drawbacks encountered to date, such as heterologous protein production, stability and purification...
July 17, 2018: Malaria Journal
Saba Gebremeskel Tekle, Angela Corpolongo, Alessandra D'Abramo, Maria Letizia Giancola, Marco Iannetta, Laura Scorzolini, Paola Marcozzi, Elsa Buffone, Giuseppina Liuzzi, Emanuele Nicastri
Congenital malaria (CM) is uncommon in both malaria-endemic and non-endemic countries. It may be caused by any Plasmodium spp., although Plasmodium falciparum and Plasmodium vivax are the more frequent etiologic agents. We report a case of delayed diagnosis of CM by P. vivax in a newborn of an Eritrean primigravida . The mother developed pregnancy-related immunodepression and varicella-zoster viral infection 9 days before natural delivery; therefore, the child was admitted in the neonatal intensive care unit (NICU) to administer specific varicella-zoster immunoglobulin prophylaxis and for clinical monitoring...
July 16, 2018: American Journal of Tropical Medicine and Hygiene
Komal Raj Rijal, Bipin Adhikari, Prakash Ghimire, Megha Raj Banjara, Borimas Hanboonkunupakarn, Mallika Imwong, Kesinee Chotivanich, Kedar Prasad Ceintury, Bibek Kumar Lal, Garib Das Thakur, Nicholas P J Day, Nicholas J White, Sasithon Pukrittayakamee
Malaria is endemic in the southern plain of Nepal which shares a porous border with India. More than 80% cases of malaria in Nepal are caused by Plasmodium vivax . The main objective of this study was to review the epidemiology of P. vivax malaria infections as recorded by the national malaria control program of Nepal between 1963 and 2016. National malaria data were retrieved from the National Malaria program in the Ministry of Health, Government of Nepal. The epidemiological trends and malariometric indicators were analyzed...
July 16, 2018: American Journal of Tropical Medicine and Hygiene
Siuhelem Rocha Silva, Anne Cristine Gomes Almeida, George Allan Villarouco da Silva, Rajendranath Ramasawmy, Stefanie Costa Pinto Lopes, André Machado Siqueira, Gabriel Luíz Costa, Taís Nóbrega Sousa, José Luiz Fernandes Vieira, Marcus Vinícius Guimarães Lacerda, Wuelton Marcelo Monteiro, Gisely Cardoso de Melo
BACKGROUND: The resistance of Plasmodium vivax to chloroquine has become an obstacle to control strategies based on the use of anti-malarials. The current study investigated the association between P. vivax CQ-resistance in vivo with copy number variation and mutations in the promoter region in pvcrt-o and pvmdr1 genes. METHODS: The study included patients with P. vivax that received supervised treatment with chloroquine and primaquine. Recurrences were actively recorded during this period...
July 16, 2018: Malaria Journal
Richard Thomson-Luque, Chengqi Wang, Francis B Ntumngia, Shulin Xu, Karoly Szekeres, Amy Conway, Swamy Rakesh Adapa, Samantha J Barnes, John H Adams, Rays H Y Jiang
Progress towards an in-depth understanding of the final steps of the erythroid lineage development is paramount for many hematological diseases. We have characterized the final stages of reticulocyte maturation from bone marrow to peripheral blood using for the first time single-cell Mass Cytometry (CyTOF). We were able to measure the expression of 31 surface markers within a single red blood cell (RBC). We demonstrate the validity of CyTOF for RBC phenotyping by confirming the progressive reduction of transferrin receptor 1 (CD71) during reticulocyte maturation to mature RBC...
July 4, 2018: Blood Cells, Molecules & Diseases
Sonal Gupta, Shailja Singh, Jean Popovici, Camille Roesch, Ahmed Rushdi Shakri, Micheline Guillotte-Blisnick, Christèle Huon, Didier Menard, Chetan E Chitnis
Plasmodium vivax merozoite invasion is restricted to Duffy positive reticulocytes. Merozoite interaction with the Duffy antigen is mediated by the P. vivax Duffy binding protein (PvDBP). The receptor-binding domain of PvDBP maps to an N-terminal cysteine-rich region referred to as region II (PvDBPII). In addition, a family of P. vivax reticulocyte binding proteins (PvRBPs) mediates interactions with reticulocyte receptors. The receptor binding domain of P. vivax reticulocyte binding protein 1a (PvRBP1a) maps to a 30 kD region (PvRBP1a30 )...
July 12, 2018: Scientific Reports
Simon J Draper, Brandon K Sack, C Richter King, Carolyn M Nielsen, Julian C Rayner, Matthew K Higgins, Carole A Long, Robert A Seder
The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success...
July 11, 2018: Cell Host & Microbe
Giselle Maria Rachid Viana, Luciana Silva-Flannery, Danielle Regina Lima Barbosa, Naomi Lucchi, Suiane Costa Negreiros do Valle, Samela Farias, Nayara Barbalho, Paola Marchesini, Juliana Chedid Nogaredi Rossi, Venkatachalam Udhayakumar, Marinete Marins Póvoa, Alexandre Macedo de Oliveira
Conventional molecular methods, such as nested polymerase chain reaction (PCR), are very sensitive for detection of malaria parasites, but require advanced laboratory equipment and trained personnel. Real-time loop-mediated isothermal amplification (RealAmp), a loop-mediated isothermal amplification-based molecular tool (LAMP), facilitates rapid target amplification at a single temperature setting, reducing the need for sophisticated equipment. We evaluated the performance of a field-adapted RealAmp assay for malaria diagnosis in Cruzeiro do Sul, Acre State, Brazil, a remote area in Brazil with limited laboratory capabilities...
2018: PloS One
Melisa Gualdrón-López, Erika L Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Dietmar Fernandez-Orth, Joan Segui-Barber, Felix Royo, Juan M Falcón-Pérez, Carmen Fernandez-Becerra, Marcus V G Lacerda, Stefan H I Kappe, Jetsumon Sattabongkot, Juan R Gonzalez, Sebastian A Mikolajczak, Hernando A Del Portillo
Exosomes are extracellular vesicles of endocytic origin containing molecular signatures implying the cell of origin; thus, they offer a unique opportunity to discover biomarkers of disease. Plasmodium vivax , responsible for more than half of all malaria cases outside Africa, is a major obstacle in the goal of malaria elimination due to the presence of dormant liver stages (hypnozoites), which after the initial infection may reactivate to cause disease. Hypnozoite infection is asymptomatic and there are currently no diagnostic tools to detect their presence...
2018: Frontiers in Microbiology
Henglin Yang, Jingyan Wang, Hui Liu, Xingliang Li, Renhua Nie, Chunfu Li, Hengye Wang, Qinghu Wang, Yaming Cao, Liwang Cui
New prophylactic drugs against malaria infections are urgently needed. We conducted randomized, double-blind, placebo-controlled, phase 2 trials of a new antimalarial drug combination, naphthoquine-azithromycin (NQAZ), to determine its safety and protective efficacy in a low-endemicity area of Southeast Asia. In the first trial, 127 healthy volunteers were randomized to receive two single-doses of either 400 mg of NQAZ (200 mg of each drug), 800 mg of NQAZ (400 mg of each drug), or placebo on day 0 and day 30...
July 9, 2018: Antimicrobial Agents and Chemotherapy
Erwan Atcheson, Karolis Bauza, Ahmed M Salman, Eduardo Alves, Joshua Blight, Martha Eva Viveros-Sandoval, Chris J Janse, Shahid M Khan, Adrian V S Hill, Arturo Reyes-Sandoval
Vivax malaria remains one of the most serious and neglected tropical diseases with 132-391 million clinical cases per year and 2.5 billion at risk of infection. A vaccine against Plasmodium vivax could have more impact than any other intervention and the use of of a vaccine targeting multiple antigens may result in higher efficacy against sporozoite infection than targeting a single antigen. Here two leading P. vivax pre-erythrocytic vaccine candidate antigens, the circumsporozoite protein (PvCSP) and the Thrombospondin Related Adhesion Protein (PvTRAP) were delivered as a combined vaccine...
July 9, 2018: Infection and Immunity
Getaneh Alemu, Mohammedaman Mama
Background: It is well known that malaria can be transmitted via blood transfusion. However, it is not documented in the national donor screening protocol. Magnitude of asymptomatic malaria among donors would be the key to decide on the need of donor screening. Despite this, there is lack of such data in Ethiopia. The aim of this study was thus to estimate the prevalence of asymptomatic malaria and associated factors among blood donors. Methods: An institution based cross-sectional study was conducted in Arba Minch blood bank from February to June, 2015...
May 2018: Ethiopian Journal of Health Sciences
Solomon Ergete, Solomon Sorsa, Eskindir Loha, Solomon Asnake
Background: Data registered in health facilities about malaria are vital source of information regarding the trend and pattern of the disease. Moreover the data also used to evaluate the impact of the intervention methods and to plan malaria control accordingly. The aim of this study was to assess the number of malaria cases in the service providing health institutions of South Omo Zone, SNNPR, over a period of seven years, 2008-2014. Methods: A retrospective review of routinely collected and recorded data on malaria was conducted at Hana and Keyafer health centers located in South OmoZone, during December-March/2014...
May 2018: Ethiopian Journal of Health Sciences
Oliver Lyth, Gema Vizcay-Barrena, Katherine E Wright, Silvia Haase, Franziska Mohring, Adrian Najer, Isabelle G Henshall, George W Ashdown, Lawrence H Bannister, Damien R Drew, James G Beeson, Roland A Fleck, Robert W Moon, Danny W Wilson, Jake Baum
Plasmodium knowlesi, a zoonotic parasite causing severe-to-lethal malaria disease in humans, has only recently been adapted to continuous culture with human red blood cells (RBCs). In comparison with the most virulent human malaria, Plasmodium falciparum, there are, however, few cellular tools available to study its biology, in particular direct investigation of RBC invasion by blood-stage P. knowlesi merozoites. This leaves our current understanding of biological differences across pathogenic Plasmodium spp...
July 5, 2018: Scientific Reports
Annie N Cowell, Hugo O Valdivia, Danett K Bishop, Elizabeth A Winzeler
BACKGROUND: Plasmodium vivax poses a significant challenge to malaria elimination due to its ability to cause relapsed infections from reactivation of dormant liver parasites called hypnozoites. We analyzed 69 P. vivax whole genome sequences obtained from subjects residing in three different villages along the Peruvian Amazon. This included 23 paired P. vivax samples from subjects who experienced recurrent P. vivax parasitemia following observed treatment with chloroquine and primaquine...
July 4, 2018: Genome Medicine
Yan Zhao, Jie Zeng, Yonghong Zhao, Qingyang Liu, Yang He, Jiaqi Zhang, Zhaoqing Yang, Qi Fan, Qinghui Wang, Liwang Cui, Yaming Cao
BACKGROUND: Border malaria, a shared phenomenon in the Greater Mekong Sub-region of Southeast Asia, is a major obstacle for regional malaria elimination. Along the China-Myanmar border, an additional problem arose as a result of the settlement of internally displaced people (IDP) in the border region. Since asymptomatic malaria significantly impacts transmission dynamics, assessment of the prevalence, dynamics and risk factors of asymptomatic malaria infections is necessary. METHODS: Cross-sectional surveys were carried out in 3 seasons (March and April, July and November) and 2 sites (villages and IDP camps) in 2015...
July 4, 2018: Malaria Journal
Zeshuai Deng, Qing Li, Haoan Yi, Yanjie Zhang, Fang Yang, Hong Li, Lan Luo, Limei Ma, Zhaoqing Yang, Yongshu He, Liwang Cui
OBJECTIVES: Hemoglobin E (HbE, β26 Glu-Lys ) is the most prevalent hemoglobinopathy in Southeast Asia. This study aimed to determine whether HbE protects against clinical Plasmodium vivax malaria in Southeast Asia. METHODS: In a case-control study performed in villages along the China-Myanmar border, we determined the prevalence of HbE in 257 villagers who had acute P. vivax infections and in 157 control healthy villagers. RESULTS: HbE in P...
June 28, 2018: Journal of Infection
Hamid Azarian Moghadam, Mehdi Nateghpour, Ahmad Raeisi, Afsane Motevalli Haghi, Gholamhosein Edrissian, Leila Farivar
Background: For many years, malaria was a major life-threatening parasitic infection in Iran. Although malaria elimination program is implementing in the country, still some cases annually are reported from malaria-endemic areas. Methods: This study was conducted in five malaria endemic districts of Sistan and Baluchistan Province, southeastern Iran, neighboring Afghanistan and Pakistan countries. Overall, 170 and 38 vivax malaria and falciparum malaria infected patients were enrolled in the study from 2013-2014...
January 2018: Iranian Journal of Parasitology
Ricardo de Souza Ribeiro, Daniela de Melo Resende, Jerônimo Conceição Ruiz, Cristiana Ferreira Alves de Brito
Plasmodium vivax is the most widely spread species causing human malaria. The control of malaria caused by P. vivax has been largely hampered by its ability to develop a dormant liver stage that can generate a new blood infection at different periods of time. Unfortunately, the mechanisms of dormancy in P. vivax have not been thoroughly elucidated to date. In this study, the putative dormancy genes were analyzed to select genes with less genetic variability to maintain the function of relapsing. Expression data concerning these genes were searched to support the selection...
June 27, 2018: Acta Tropica
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