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plasmodium vivax malaria

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https://www.readbyqxmd.com/read/29771281/high-risk-of-plasmodium-vivax-malaria-following-splenectomy-in-papua-indonesia
#1
Steven Kho, Benediktus Andries, Jeanne R Poespoprodjo, Robert J Commons, Putu A I Shanti, Enny Kenangalem, Nicholas M Douglas, Julie A Simpson, Paulus Sugiarto, Nicholas M Anstey, Ric N Price
Background: Splenectomy increase the risk of severe and fatal infections, however the risk of Plasmodium vivax malaria is unknown. We quantified the Plasmodium species-specific risks of malaria and other outcomes following splenectomy in patients attending a hospital in Papua, Indonesia. Methods: Records of all patients attending Mitra-Masyarakat Hospital 2004-2013 were reviewed, identifying those who underwent splenectomy. Subsequent risks of specific clinical outcomes within 12 months for splenectomized patients were compared to non-splenectomized patients from their first recorded hospital admission...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29769075/microclimate-variables-of-the-ambient-environment-deliver-the-actual-estimates-of-the-extrinsic-incubation-period-of-plasmodium-vivax-and-plasmodium-falciparum-a-study-from-a-malaria-endemic-urban-setting-chennai-in-india
#2
Shalu Thomas, Sangamithra Ravishankaran, N A Johnson Amala Justin, Aswin Asokan, T Maria Jusler Kalsingh, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B Thomas, Alex Eapen
BACKGROUND: Environmental factors such as temperature, relative humidity and their daily variation influence a range of mosquito life history traits and hence, malaria transmission. The standard way of characterizing environmental factors with meteorological station data need not be the actual microclimates experienced by mosquitoes within local transmission settings. METHODS: A year-long study was conducted in Chennai, India to characterize local temperature and relative humidity (RH)...
May 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29765020/changes-in-genome-organization-of-parasite-specific-gene-families-during-the-plasmodium-transmission-stages
#3
Evelien M Bunnik, Kate B Cook, Nelle Varoquaux, Gayani Batugedara, Jacques Prudhomme, Anthony Cort, Lirong Shi, Chiara Andolina, Leila S Ross, Declan Brady, David A Fidock, Francois Nosten, Rita Tewari, Photini Sinnis, Ferhat Ay, Jean-Philippe Vert, William Stafford Noble, Karine G Le Roch
The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29761766/factors-associated-with-the-rapid-and-durable-decline-in-malaria-incidence-in-el-salvador-1980-2017
#4
Robert A Burton, José Eduardo Romero Chévez, Mauricio Sauerbrey, Caterina Guinovart, Angela Hartley, Geoffrey Kirkwood, Matthew Boslego, Mirna Elizabeth Gavidia, Jaime Enrique Alemán Escobar, Rachel Turkel, Richard W Steketee, Laurence Slutsker, Kammerle Schneider, Carlos C Kent Campbell
A decade after the Global Malaria Eradication Program, El Salvador had the highest burden of malaria in Mesoamerica, with approximately 20% due to Plasmodium falciparum . A resurgence of malaria in the 1970s led El Salvador to alter its national malaria control strategy. By 1995, El Salvador recorded its last autochthonous P. falciparum case with fewer than 20 Plasmodium vivax cases annually since 2011. By contrast, its immediate neighbors continue to have the highest incidences of malaria in the region. We reviewed and evaluated the policies and interventions implemented by the Salvadoran National Malaria Program that likely contributed to this progress toward malaria elimination...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29761758/genetic-variability-of-plasmodium-vivax-in-the-north-coast-of-peru-and-the-ecuadorian-amazon-basin
#5
Julio A Ventocilla, Jorge Nuñez, Laura Lorena Tapia, Carmen M Lucas, Stephen R Manock, Andrés G Lescano, Kimberly A Edgel, Paul C F Graf
In the Peruvian North Coast (PNC), the number of Plasmodium vivax malaria cases increased steadily from 2007 to 2010 despite a significant decline in the overall number of cases in Peru during the same period. To better understand the transmission dynamics of P. vivax populations in the PNC and the neighboring Ecuadorian Amazon Basin (EAB), we studied the genetic variability and population structure of P. vivax in these areas. One hundred and twenty P. vivax isolates (58 from Piura and 37 from Tumbes in the PNC collected from 2008 to 2010 and 25 from the EAB collected in Pastaza from 2001 to 2004) were assessed by five polymorphic microsatellite markers...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29756074/discovery-of-small-molecules-through-pharmacophore-modeling-docking-and-molecular-dynamics-simulation-against-plasmodium-vivax-vivapain-3-vp-3
#6
Madhu Sudhana Saddala, Pradeepkiran Jangampalli Adi
Vivapain-3(VP-3) protein is a family of cysteine rich proteases of malaria parasite is extensively reported to participate in a range of wide cellular processes including survival. VP-3 of plasmodium recognized as an attractive drug target in vector-borne diseases like malaria. In the present study we robust a homology model of VP-3 protein and generated the pharmacophore based models adapted to screen the best drug like compounds from PubChem database. Our results finds the fourteen best lead molecules were mapped with core pharmacophore features of VP-3 and top hits were further evaluated by molecular dynamics simulation and docking studies...
May 2018: Heliyon
https://www.readbyqxmd.com/read/29754588/evaluating-seroprevalence-to-circumsporozoite-protein-to-estimate-exposure-to-three-species-of-plasmodium-in-the-brazilian-amazon
#7
Virginia Araujo Pereira, Juan Camilo Sánchez-Arcila, Mariana Pinheiro Alves Vasconcelos, Amanda Ribeiro Ferreira, Lorene de Souza Videira, Antonio Teva, Daiana Perce-da-Silva, Maria Teresa Queiroz Marques, Luzia Helena de Carvalho, Dalma Maria Banic, Luiz Cristóvão Sobrino Pôrto, Joseli Oliveira-Ferreira
BACKGROUND: Brazil has seen a great decline in malaria and the country is moving towards elimination. However, for eventual elimination, the control program needs efficient tools in order to monitor malaria exposure and transmission. In this study, we aimed to evaluate whether seroprevalence to the circumsporozoite protein (CSP) is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian Amazon. METHODS: Cross-sectional surveys were conducted in a rural area of Porto Velho, Rondônia state...
May 14, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29743474/a-comprehensive-model-for-assessment-of-liver-stage-therapies-targeting-plasmodium-vivax-and-plasmodium-falciparum
#8
Alison Roth, Steven P Maher, Amy J Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A Kaba, Amélie Vantaux, Malina A Bakowski, Richard Thomson Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J Barnes, Caitlin A Cooper, Mélanie Rouillier, Case W McNamara, Sebastian A Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H I Kappe, David E Lanar, François Nosten, Silas Davidson, Rays H Y Jiang, Dennis E Kyle, John H Adams
Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P. falciparum lack the efficiency necessary for rapid identification and effective evaluation of new vaccines and drugs, especially targeting late liver-stage development and hypnozoites. Herein we report the development of a 384-well plate culture system using commercially available materials, including cryopreserved primary human hepatocytes...
May 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29742871/the-effect-of-abo-blood-groups-hemoglobinopathy-and-heme-oxygenase-1-polymorphisms-on-malaria-susceptibility-and-severity
#9
Jiraporn Kuesap, Kesara Na-Bangchang
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity such as blood group, hemoglobinopathy, and heme oxygenase-1 (HO-1) polymorphisms. This study was carried out to investigate association among ABO blood group, thalassemia types and HO-1 polymorphisms in malaria. The malarial blood samples were collected from patients along the Thai-Myanmar border. Determination of ABO blood group, thalassemia variants, and HO-1 polymorphisms were performed using agglutination test, low pressure liquid chromatography and polymerase chain reaction, respectively...
April 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29741629/identification-and-immunological-characterization-of-the-ligand-domain-of-plasmodium-vivax-reticulocyte-binding-protein-1a
#10
Francis B Ntumngia, Richard Thomson-Luque, Sandra Galusic, Gabriel Frato, Sarah Frischmann, David S Peabody, Bryce Chackerian, Marcelo U Ferreira, Christopher L King, John H Adams
Background: Erythrocyte invasion by malaria parasites is essential for blood-stage development. Consequently, parasite proteins critically involved in erythrocyte invasion such as the Plasmodium vivax reticulocyte-binding proteins (RBPs) that mediate preferential invasion of reticulocytes are considered potential vaccine targets. Thus, targeting the RBPs could prevent blood-stage infection and disease. The RBPs are large and little is known about their functional domains and whether individuals naturally exposed to P...
May 7, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29741155/the-hidden-burden-of-plasmodium-vivax-malaria-in-pregnancy-in-the-amazon-an-observational-study-in-northwestern-brazil
#11
Anaclara Pincelli, Paulo A R Neves, Barbara H Lourenço, Rodrigo M Corder, Maíra B Malta, Juliana Sampaio-Silva, Rodrigo M de Souza, Marly A Cardoso, Marcia C Castro, Marcelo U Ferreira, For The Mina Brazil Working Group
We measured the prevalence of malaria in pregnancy and estimated its impact on birth weight and length and maternal hemoglobin in 1,180 women from Juruá Valley, the main malaria hotspot in Brazil. Antenatal malaria episodes, 74.6% of them due to Plasmodium vivax , were microscopically diagnosed in 8.0% of the women and were associated with an average reduction in birth weight z -scores of 0.35 (95% confidence interval [CI] = 0.14-0.57) and in birth length z -scores of 0.31 (95% CI = 0.08-0.54), compared with malaria-free pregnancies...
May 7, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29739900/bone-marrow-is-a-major-parasite-reservoir-in-plasmodium-vivax-infection
#12
Nicanor Obaldia, Elamaran Meibalan, Juliana M Sa, Siyuan Ma, Martha A Clark, Pedro Mejia, Roberto R Moraes Barros, William Otero, Marcelo U Ferreira, James R Mitchell, Danny A Milner, Curtis Huttenhower, Dyann F Wirth, Manoj T Duraisingh, Thomas E Wellems, Matthias Marti
Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide. Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation, and it is often assumed that accumulation/sequestration in tissues is not an important phase in their development. Here, we present a systematic study of P. vivax stage distributions in infected tissues of nonhuman primate (NHP) malaria models as well as in blood from human infections. In a comparative analysis of the transcriptomes of P...
May 8, 2018: MBio
https://www.readbyqxmd.com/read/29738562/validation-of-the-quantitative-point-of-care-carestart-biosensor-for-assessment-of-g6pd-activity-in-venous-blood
#13
Germana Bancone, Gornpan Gornsawun, Cindy S Chu, Pen Porn, Sampa Pal, Pooja Bansil, Gonzalo J Domingo, Francois Nosten
INTRODUCTION: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in the human population affecting an estimated 8% of the world population, especially those living in areas of past and present malaria endemicity. Decreased G6PD enzymatic activity is associated with drug-induced hemolysis and increased risk of severe neonatal hyperbilirubinemia leading to brain damage. The G6PD gene is on the X chromosome therefore mutations cause enzymatic deficiency in hemizygote males and homozygote females while the majority of heterozygous females have an intermediate activity (between 30-80% of normal) with a large distribution into the range of deficiency and normality...
2018: PloS One
https://www.readbyqxmd.com/read/29728152/infection-of-anopheles-aquasalis-from-symptomatic-and-asymptomatic-plasmodium-vivax-infections-in-manaus-western-brazilian-amazon
#14
Keillen M Martins-Campos, Andrea Kuehn, Anne Almeida, Ana Paula M Duarte, Vanderson S Sampaio, Íria C Rodriguez, Sara G M da Silva, Claudia María Ríos-Velásquez, José Bento Pereira Lima, Paulo Filemon Paolucci Pimenta, Quique Bassat, Ivo Müller, Marcus Lacerda, Wuelton M Monteiro, Maria das Graças V Barbosa Guerra
BACKGROUND: Asymptomatic individuals are one of the major challenges for malaria elimination programs in endemic areas. In the absence of clinical symptoms and with a lower parasite density they constitute silent reservoirs considered important for maintaining transmission of human malaria. Studies from Brazil have shown that infected individuals may carry these parasites for long periods. RESULTS: Patients were selected from three periurban endemic areas of the city of Manaus, in the western Brazilian Amazon...
May 4, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29724225/towards-development-of-aptamers-that-specifically-bind-to-lactate-dehydrogenase-of-plasmodium-falciparum-through-epitopic-targeting
#15
Kelly-Anne Frith, Ronen Fogel, J P Dean Goldring, Robert G E Krause, Makobetsa Khati, Heinrich Hoppe, Mary E Cromhout, Meesbah Jiwaji, Janice L Limson
BACKGROUND: Early detection is crucial for the effective treatment of malaria, particularly in those cases infected with Plasmodium falciparum. There is a need for diagnostic devices with the capacity to distinguish P. falciparum from other strains of malaria. Here, aptamers generated against targeted species-specific epitopes of P. falciparum lactate dehydrogenase (rPfLDH) are described. RESULTS: Two classes of aptamers bearing high binding affinity and specificity for recombinant P...
May 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29723510/infection-of-mosquitoes-from-in-vitro-cultivated-plasmodium-knowlesi-h-strain
#16
Jennifer S Armistead, Roberto R Moraes Barros, Tyler J Gibson, Whitney A Kite, J Patrick Mershon, Lynn E Lambert, Sachy E Orr-Gonzalez, Juliana M Sá, John H Adams, Thomas E Wellems
In vitro studies of sexual blood stages of the most fatal malaria species, Plasmodium falciparum, have revealed key processes by which gametocytes develop and transmit infection from humans to anopheline mosquitoes. However, most malaria cases outside sub-Saharan Africa are caused by other Plasmodium spp., frequently Plasmodium vivax and Plasmodium knowlesi, a zoonotic parasite of macaque monkeys. Gametocytes of P. vivax and P. knowlesi exhibit distinct morphology, faster development, and a shorter life span compared with gametocytes of P...
April 30, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29723168/malaria-surveillance-united-states-2015
#17
Kimberly E Mace, Paul M Arguin, Kathrine R Tan
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles species mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
May 4, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29720188/two-clusters-of-plasmodium-knowlesi-cases-in-a-malaria-elimination-area-sabang-municipality-aceh-indonesia
#18
Herdiana Herdiana, Irnawati Irnawati, Farah Novita Coutrier, Alfian Munthe, Mardiati Mardiati, Titik Yuniarti, Elvieda Sariwati, Maria Endang Sumiwi, Rintis Noviyanti, Paul Pronyk, William A Hawley
In malaria elimination areas, malaria cases are sporadic and consist predominantly of imported cases. Plasmodium knowlesi cases have been reported throughout Southeast Asia where long-tailed and pig-tailed macaques and Anopheles leucosphyrus group mosquitoes are sympatric. The limitation of microscopic examination to diagnose P. knowlesi is well known. In consequence, no P. knowlesi case has previously been reported from routine health facility-based case finding activities in Indonesia. This report describes two clusters of unexpected locally acquired P...
May 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29720181/multiplicity-and-molecular-epidemiology-of-plasmodium-vivax-and-plasmodium-falciparum-infections-in-east-africa
#19
Daibin Zhong, Eugenia Lo, Xiaoming Wang, Delenasaw Yewhalaw, Guofa Zhou, Harrysone E Atieli, Andrew Githeko, Elizabeth Hemming-Schroeder, Ming-Chieh Lee, Yaw Afrane, Guiyun Yan
BACKGROUND: Parasite genetic diversity and multiplicity of infection (MOI) affect clinical outcomes, response to drug treatment and naturally-acquired or vaccine-induced immunity. Traditional methods often underestimate the frequency and diversity of multiclonal infections due to technical sensitivity and specificity. Next-generation sequencing techniques provide a novel opportunity to study complexity of parasite populations and molecular epidemiology. METHODS: Symptomatic and asymptomatic Plasmodium vivax samples were collected from health centres/hospitals and schools, respectively, from 2011 to 2015 in Ethiopia...
May 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29720179/structural-patterns-of-selection-and-diversity-for-plasmodium-vivax-antigens-dbp-and-ama1
#20
Andrew J Guy, Vashti Irani, Jack S Richards, Paul A Ramsland
BACKGROUND: Plasmodium vivax is a significant contributor to the global malaria burden, and a vaccine targeting vivax malaria is urgently needed. An understanding of the targets of functional immune responses during the course of natural infection will aid in the development of a vaccine. Antibodies play a key role in this process, with responses against particular epitopes leading to immune selection pressure on these epitopes. A number of techniques exist to estimate levels of immune selection pressure on particular epitopes, with a sliding window analysis often used to determine particular regions likely to be under immune pressure...
May 2, 2018: Malaria Journal
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