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plasmodium vivax malaria

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https://www.readbyqxmd.com/read/28213436/host-cell-tropism-and-adaptation-of-blood-stage-malaria-parasites-challenges-for-malaria-elimination
#1
Caeul Lim, Selasi Dankwa, Aditya S Paul, Manoj T Duraisingh
Plasmodium falciparum and Plasmodium vivax account for most of the mortality and morbidity associated with malaria in humans. Research and control efforts have focused on infections caused by P. falciparum and P. vivax, but have neglected other malaria parasite species that infect humans. Additionally, many related malaria parasite species infect nonhuman primates (NHPs), and have the potential for transmission to humans. For malaria elimination, the varied and specific challenges of all of these Plasmodium species will need to be considered...
February 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28202065/alternative-transmission-routes-in-the-malaria-elimination-era-an-overview-of-transfusion-transmitted-malaria-in-the-americas
#2
Regina M Alho, Kim Vinícius Amaral Machado, Fernando F A Val, Nelson A Fraiji, Marcia A A Alexandre, Gisely C Melo, Judith Recht, André M Siqueira, Wuelton M Monteiro, Marcus V G Lacerda
BACKGROUND: Transfusion-transmitted (TT) malaria is an alternative infection route that has gained little attention from authorities, despite representing a life-threatening condition. There has been no systematic review of this health problem in American countries. The aim of this study was to describe the clinical and epidemiological characteristics of TT malaria in the Americas and identify factors associated with lethality based on the studies published in the literature. METHODS: Potentially relevant papers in all languages were retrieved from MEDLINE and LILACS...
February 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28196496/molecular-evidence-of-plasmodium-vivax-infection-in-duffy-negative-symptomatic-individuals-from-dschang-west-cameroon
#3
Gianluca Russo, Giovanni Faggioni, Giacomo Maria Paganotti, Ghyslaine Bruna Djeunang Dongho, Alice Pomponi, Riccardo De Santis, Gianpiero Tebano, Mpoame Mbida, Martin Sanou Sobze, Vincenzo Vullo, Giovanni Rezza, Florigio Romano Lista
BACKGROUND: Plasmodium vivax infection is known to be rare in West/Central Africa, the most accepted explanation being the lack of expression of erythroid Duffy antigen in the local human populations. Duffy negativity prevents the parasite to exploit the entry mechanism on the red blood cell surface. However, there are a growing number of reported vivax infections in Duffy-negative individuals. Data on P. vivax circulation in Cameroon are limited. The aim of the study was to evaluate the P...
February 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28183358/genetic-diversity-and-population-structure-of-the-primary-malaria-vector-anopheles-sinensis-diptera-culicidae-in-china-inferred-by-cox1-gene
#4
Xinyu Feng, Libin Huang, Lin Lin, Manni Yang, Yajun Ma
BACKGROUND: Anopheles sinensis is a primary vector for Plasmodium vivax malaria in most regions of China. A comprehensive understanding of genetic variation and structure of the mosquito would be of benefit to the vector control and in a further attempt to contribute to malaria elimination in China. However, there is only inadequate population genetic data pertaining to An. sinensis currently. METHODS: Genetic variations and structure among populations of An. sinensis was examined and analyzed based on the nucleotide sequences of a 662 nt variable region of the mitochondrial cox1 gene among 15 populations from 20 collection sites in China...
February 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28179404/a-plasmodium-vivax-plasmid-dna-and-adenovirus-vectored-malaria-vaccine-encoding-blood-stage-antigens-ama1-and-msp142-in-a-prime-boost-heterologous-immunization-regimen-partially-protects-aotus-monkeys-against-blood-stage-challenge
#5
Nicanor Obaldia, Michael G Stockelman, William Otero, Jennifer A Cockrill, Harini Ganeshan, Esteban N Abot, Jianfeng Zhang, Keith Limbach, Yupin Charoenvit, Denise L Doolan, De-Chu C Tang, Thomas L Richie
Malaria is caused by parasites of the genus Plasmodium that are transmitted to humans by the bites of Anopheles mosquitoes. After the elimination of P. falciparum it is predicted that Plasmodium vivax will remain an important cause of morbidity and mortality outside of Africa, stressing the importance of developing a vaccine against malaria. In this study we assess the immunogenicity and protective efficacy of two P. vivax antigens, AMA1 and MSP142 in a recombinant DNA plasmid prime/adenoviral vector (Ad) boost regimen in Aotus monkeys...
February 8, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28179403/evaluation-of-pvceltos-as-a-pre-erythrocytic-p-vivax-vaccine
#6
Eduardo Alves, Ahmed M Salman, Fabiana Leoratti, Cesar Lopez-Camacho, Martha Eva Viveros-Sandoval, Amar Lall, Aadil El-Turabi, Martin F Bachmann, Adrian V S Hill, Chris J Janse, Shahid M Khan, Arturo Reyes-Sandoval
Four different vaccine platforms each targeting the human malaria parasite Plasmodium vivax cell-traversal protein for ookinetes and sporozoites (PvCelTOS) were generated and assessed for protective efficacy. These platforms consisted of a recombinant chimpanzee adenoviral vector ChAd63-PvCelTOS (Ad); a recombinant MVA-PvCelTOS (MVA); a bacteriophage Qβ-PvCelTOS virus-like particle (VLP); and recombinant PvCelTOS protein expressed in eukaryotic HEK293T cells (protein). Inbred BALB/c and outbred CD-1 mice were immunized using the following prime/boost regimens: Ad-MVA, Ad-VLP and Ad-protein...
February 8, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28174312/selective-whole-genome-amplification-is-a-robust-method-that-enables-scalable-whole-genome-sequencing-of-plasmodium-vivax-from-unprocessed-clinical-samples
#7
Annie N Cowell, Dorothy E Loy, Sesh A Sundararaman, Hugo Valdivia, Kathleen Fisch, Andres G Lescano, G Christian Baldeviano, Salomon Durand, Vince Gerbasi, Colin J Sutherland, Debbie Nolder, Joseph M Vinetz, Beatrice H Hahn, Elizabeth A Winzeler
: Whole-genome sequencing (WGS) of microbial pathogens from clinical samples is a highly sensitive tool used to gain a deeper understanding of the biology, epidemiology, and drug resistance mechanisms of many infections. However, WGS of organisms which exhibit low densities in their hosts is challenging due to high levels of host genomic DNA (gDNA), which leads to very low coverage of the microbial genome. WGS of Plasmodium vivax, the most widely distributed form of malaria, is especially difficult because of low parasite densities and the lack of an ex vivo culture system...
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28170391/haemolysis-in-g6pd-heterozygous-females-treated-with-primaquine-for-plasmodium-vivax-malaria-a-nested-cohort-in-a-trial-of-radical-curative-regimens
#8
Cindy S Chu, Germana Bancone, Kerryn A Moore, Htun Htun Win, Niramon Thitipanawan, Christina Po, Nongnud Chowwiwat, Rattanaporn Raksapraidee, Pornpimon Wilairisak, Aung Pyae Phyo, Lily Keereecharoen, Stéphane Proux, Prakaykaew Charunwatthana, François Nosten, Nicholas J White
BACKGROUND: Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD heterozygous females, because of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cells, may have low G6PD activity in the majority of their erythrocytes, yet are usually reported as G6PD "normal" by current phenotypic screening tests...
February 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28166727/whole-genome-sequencing-of-a-plasmodium-vivax-clinical-isolate-exhibits-geographical-characteristics-and-high-genetic-variation-in-china-myanmar-border-area
#9
Shen-Bo Chen, Yue Wang, Kokouvi Kassegne, Bin Xu, Hai-Mo Shen, Jun-Hu Chen
BACKGROUND: Currently in China, the trend of Plasmodium vivax cases imported from Southeast Asia was increased especially in the China-Myanmar border area. Driven by the increase in P. vivax cases and stronger need for vaccine and drug development, several P. vivax isolates genome sequencing projects are underway. However, little is known about the genetic variability in this area until now. RESULTS: The sequencing of the first P. vivax isolate from China-Myanmar border area (CMB-1) generated 120 million paired-end reads...
February 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28163236/evolution-of-the-merozoite-surface-protein-7-msp7-family-in-plasmodium-vivax-and-p-falciparum-a-comparative-approach
#10
Andreína I Castillo, M Andreína Pacheco, Ananias A Escalante
Malaria parasites (genus Plasmodium) are a diverse group found in many species of vertebrate hosts. These parasites invade red blood cells in a complex process comprising several proteins, many encoded by multigene families, one of which is merozoite surface protein 7 (msp7). In the case of Plasmodium vivax, the most geographically widespread human-infecting species, differences in the number of paralogs within multigene families have been previously explained, at least in part, as potential adaptations to the human host...
February 2, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28157657/detecting-circulating-antibodies-by-controlled-surface-modification-with-specific-target-proteins-application-to-malaria
#11
Ana R Cardoso, Gustavo Cabral-Miranda, Arturo Reyes-Sandoval, Martin F Bachmann, M Goreti F Sales
Sensitive detection of specific antibodies by biosensors has become of major importance for monitoring and controlling epidemics. Here we report a development of a biosensor able to specifically measure antibodies in a drop of unmodified blood serum. Within minutes, the detection system measures presence of antibodies against Plasmodium vivax, a causing agent for malaria. The biosensor consists of a layer of carbon nanotubes (CNTs) which were casted on a carbon working electrode area of a three-electrode system and oxidized...
January 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28153009/genetic-diversity-of-plasmodium-vivax-metacaspase-1-and-plasmodium-vivax-multi-drug-resistance-1-genes-of-field-isolates-from-mauritania-sudan-and-oman
#12
Fatimata Sow, Guillaume Bonnot, Bilal Rabah Ahmed, Sidi Mohamed Diagana, Hachim Kebe, Mohamedou Koita, Ba Malado Samba, Said K Al-Mukhaini, Majed Al-Zadjali, Seif S Al-Abri, Osama A M Ali, Abdallah M Samy, Muzamil Mahdi Abdel Hamid, Musab M Ali Albsheer, Bruno Simon, Anne-Lise Bienvenu, Eskild Petersen, Stéphane Picot
BACKGROUND: Plasmodium vivax is the second most important human malaria parasite, widely spread across the world. This parasite is associated with important issues in the process toward malaria elimination, including potential for relapse and increased resistance to chloroquine. Plasmodium vivax multi-drug resistant (pvmdr1) is suspected to be a marker of resistance although definitive evidence is lacking. Progress has been made in knowledge of biological factors affecting parasite growth, including mechanisms of regulated cell death and the suspected role of metacaspase...
February 2, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28148300/increase-in-imported-malaria-in-the-netherlands-in-asylum-seekers-and-vfr-travellers
#13
Brechje de Gier, Franciska S T Suryapranata, Mieke Croughs, Perry J J van Genderen, Monique Keuter, Leo G Visser, Michele van Vugt, Gerard J B Sonder
BACKGROUND: Malaria is a notifiable disease in the Netherlands, a non-endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015. Trends in amounts of notifications among risk groups were analysed using Poisson regression. For asylum seekers, yearly incidence was calculated per region of origin, using national asylum request statistics as denominator data. For tourists, denominator data were used from travel statistics to estimate incidence per travel region up to 2012...
February 2, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28146461/clinical-picture-of-imported-plasmodium-vivax-malaria-in-patients-of-a-polish-tertiary-center
#14
Anna Kuna, Agnieszka Wroczyńska, Martyna Bykowska, Natalia Kulawiak, Weronika Rymer, Joanna Stańczak
No abstract text is available yet for this article.
January 31, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28143518/submicroscopic-plasmodium-prevalence-in-relation-to-malaria-incidence-in-20-villages-in-western-cambodia
#15
Rupam Tripura, Thomas J Peto, Christianne C Veugen, Chea Nguon, Chan Davoeung, Nicola James, Mehul Dhorda, Richard J Maude, Jureeporn Duanguppama, Krittaya Patumrat, Mallika Imwong, Lorenz von Seidlein, Martin P Grobusch, Nicholas J White, Arjen M Dondorp
BACKGROUND: Cambodia has seen a marked reduction in the incidence of Plasmodium falciparum over the past decade without a corresponding decline in Plasmodium vivax incidence. It is unknown to what extent local transmission is sustained by a chain of clinical and sub-clinical infections or by continued re-introduction via migration. Using an ultrasensitive molecular technique, 20 villages in western Cambodia were surveyed to detect the low season prevalence of P. falciparum and P. vivax and local treatment records were reviewed...
January 31, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28140603/update-malaria-u-s-armed-forces-2016
#16
(no author information available yet)
Malaria infection remains an important health threat to U.S. service members who are located in endemic areas because of long-term duty assignments, participation in shorter-term contingency operations, or personal travel. In 2016, 57 service members were diagnosed with or reported to have malaria, which is the highest number of cases since 2011 (n=124). The relatively low numbers of cases during 2012-2016 mainly reflect decreases in cases acquired in Afghanistan, a reduction due largely to the progressive withdrawal of U...
January 2017: MSMR
https://www.readbyqxmd.com/read/28139780/specific-and-sensitive-detection-of-plasmodium-falciparum-lactate-dehydrogenase-by-dna-scaffolded-silver-nanoclusters-combined-with-an-aptamer
#17
Wei-Xian Wang, Yee-Wai Cheung, Roderick M Dirkzwager, Wai-Chung Wong, Julian A Tanner, Hong-Wei Li, Yuqing Wu
Innovative nanomaterials offer significant potential for diagnosis of severe diseases of the developing world such as malaria. Small sized silver nanoclusters have shown promise for diagnostics due to their intense fluorescence emission and photo-stabilities. Here, double-stranded DNA-scaffolded silver nanoclusters (AgNCs-dsDNA) were prepared to detect the established malaria biomarker, Plasmodium falciparum lactate dehydrogenase (PfLDH). Significant luminescence enhancement over a wide concentration range of PfLDH was demonstrated...
January 31, 2017: Analyst
https://www.readbyqxmd.com/read/28138056/outbreak-investigation-of-plasmodium-vivax-malaria-in-a-region-of-guatemala-targeted-for-malaria-elimination
#18
Robert Cohen, Joel Sarceño Cardona, Eliana Solares Navarro, Norma Padilla, Lisette Reyes, Rodrigo Javier Pinto Villar, Penny Masuoka, Chris Bernart, Leonard F Peruski, Joe P Bryan
The Department of Santa Rosa, Guatemala, is targeted for malaria elimination. However, compared with 2011, a 13-fold increase in cases was reported in 2012. To describe the epidemiology of malaria in Santa Rosa in the setting of the apparent outbreak, demographic and microscopic data from 2008 to 2013 were analyzed. In April 2012, a new surveillance strategy, funded by the Global Fund to Fight AIDS, Tuberculosis and Malaria, was introduced involving more active case detection, centralized microscopy, increased community engagement, and expanded vector control...
January 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28137270/malaria-control-and-prevention-towards-elimination-data-from-an-eleven-year-surveillance-in-shandong-province-china
#19
Xiangli Kong, Xin Liu, Hong Tu, Yan Xu, Jianbing Niu, Yongbin Wang, Changlei Zhao, Jingxuan Kou, Jun Feng
BACKGROUND: Shandong Province experienced a declining malaria trend of local-acquired transmission, but the increasing imported malaria remains a challenge. Therefore, understanding the epidemiological characteristics of malaria and the control and elimination strategy and interventions is needed for better planning to achieve the overall elimination goal in Shandong Province. METHODS: A retrospective study was conducted and all individual cases from a web-based reporting system were reviewed and analysed to explore malaria-endemic characteristics in Shandong from 2005 to 2015...
January 31, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28129766/severe-plasmodium-vivax-infection-in-korea
#20
Jae Hyoung Im, Hea Yoon Kwon, JiHyeon Baek, Seong Wook Park, Areum Durey, Kyung Hee Lee, Moon-Hyun Chung, Jin-Soo Lee
BACKGROUND: Although severe malaria by Plasmodium vivax has been increasingly reported, there are marked variations in the type and rate of the complications by geographic area. This is possibly because of the presence of concurrent falciparum malaria or bacteraemia, and of differences in underlying immune status among the infected subjects. Furthermore, published studies on P. vivax in temperate regions are limited. The present study investigated severe vivax malaria in Korea, where only vivax malaria occurs...
January 28, 2017: Malaria Journal
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