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plasmodium vivax malaria

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https://www.readbyqxmd.com/read/27930652/safety-and-reproducibility-of-a-clinical-trial-system-using-induced-blood-stage-plasmodium-vivax-infection-and-its-potential-as-a-model-to-evaluate-malaria-transmission
#1
Paul Griffin, Cielo Pasay, Suzanne Elliott, Silvana Sekuloski, Maggy Sikulu, Leon Hugo, David Khoury, Deborah Cromer, Miles Davenport, Jetsumon Sattabongkot, Karen Ivinson, Christian Ockenhouse, James McCarthy
BACKGROUND: Interventions to interrupt transmission of malaria from humans to mosquitoes represent an appealing approach to assist malaria elimination. A limitation has been the lack of systems to test the efficacy of such interventions before proceeding to efficacy trials in the field. We have previously demonstrated the feasibility of induced blood stage malaria (IBSM) infection with Plasmodium vivax. In this study, we report further validation of the IBSM model, and its evaluation for assessment of transmission of P...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27911780/selective-sweep-suggests-transcriptional-regulation-may-underlie-plasmodium-vivax-resilience-to-malaria-control-measures-in-cambodia
#2
Christian M Parobek, Jessica T Lin, David L Saunders, Eric J Barnett, Chanthap Lon, Charlotte A Lanteri, Sujata Balasubramanian, Nicholas Brazeau, Derrick K DeConti, Deen L Garba, Steven R Meshnick, Michele D Spring, Char Meng Chuor, Jeffrey A Bailey, Jonathan J Juliano
Cambodia, in which both Plasmodium vivax and Plasmodium falciparum are endemic, has been the focus of numerous malaria-control interventions, resulting in a marked decline in overall malaria incidence. Despite this decline, the number of P vivax cases has actually increased. To understand better the factors underlying this resilience, we compared the genetic responses of the two species to recent selective pressures. We sequenced and studied the genomes of 70 P vivax and 80 P falciparum isolates collected between 2009 and 2013...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27906962/population-density-climate-variables-and-poverty-synergistically-structure-spatial-risk-in-urban-malaria-in-india
#3
Mauricio Santos-Vega, Menno J Bouma, Vijay Kohli, Mercedes Pascual
BACKGROUND: The world is rapidly becoming urban with the global population living in cities projected to double by 2050. This increase in urbanization poses new challenges for the spread and control of communicable diseases such as malaria. In particular, urban environments create highly heterogeneous socio-economic and environmental conditions that can affect the transmission of vector-borne diseases dependent on human water storage and waste water management. Interestingly India, as opposed to Africa, harbors a mosquito vector, Anopheles stephensi, which thrives in the man-made environments of cities and acts as the vector for both Plasmodium vivax and Plasmodium falciparum, making the malaria problem a truly urban phenomenon...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27905633/-failure-to-radical-cure-in-plasmodium-vivax-malaria
#4
Julián García, Agustín Seijo, Andrés Benchetrit, Esteban Couto, Sofía Echazarreta, Susana Lloveras, Tomás Orduna
Relapsing Plasmodium vivax malaria is due to activation of dormant intrahepatic parasitic forms known as hypnozoits. Primaquine is the only available drug effective against hypnozoits and, alongside a schizonticidal drug, constitutes the radical treatment of malaria. Failure of radical treatment is frequently attributed to inadequate dosing, poor adherence, or reinfection. However, several cases of radical treatment failure without these factors have been reported, inferring that metabolic properties of the host or tolerance mechanisms of the parasite may be implied...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27905280/diagnosis-and-species-discrimination-of-positive-malaria-samples-by-real-time-polymerase-chain-reaction
#5
Esra Atalay Şahar, Muhammet Karakavuk, Hüseyin Can, Şebnem Nergiz, Kadri Gül, Aysu Değirmenci Döşkaya, Yüksel Gürüz, Mert Döşkaya
OBJECTIVE: Malaria is an important tropical disease that is detected in 198 million people and causes 367-755 thousand deaths annually. Recently, the real-time Polymerase Chain Reaction (PCR) technique has enabled quick determination of Plasmodium spp. and species identification in the same assay with a low contamination risk. In the present study, we aimed to use real-time PCR targeting the 18S rRNA gene to diagnose Plasmodium spp. and perform species identification. METHODS: DNA samples of 15 patients with malaria (14 caused by P...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27903051/spatial-and-spatio-temporal-analysis-of-malaria-in-the-state-of-acre-western-amazon-brazil
#6
Leonardo Augusto Kohara Melchior, Francisco Chiaravalloti Neto
Since 2005, the State of Acre, western Amazon, Brazil, has reported the highest annual parasite incidence (API) of malaria among the Brazilian states. This study examines malaria incidence in Acre using spatial and spatio-temporal analysis based on an ecological time series study analyzing malaria cases and deaths for the time period 1992- 2014 and using secondary data. API indexes were calculated by age, sex, parasite species, ratio of Plasmodium vivax to P. falciparum malaria, malaria mortality rate and case fatality rate...
November 16, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27899329/plasmodium-vivax-vaccine-research-we-ve-only-just-begun
#7
REVIEW
Wai-Hong Tham, James G Beeson, Julian C Rayner
Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause of severe disease. The unique attributes of P. vivax biology, particularly the capacity of the dormant liver stage, the hypnozoite, to maintain blood-stage infections even in the absence of active transmission, make blood-stage vaccines particularly attractive for this species. However, P. vivax vaccine development remains resolutely in first gear, with only a single blood-stage candidate having been evaluated in any depth...
November 27, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27899135/analysis-of-pvama1-genes-from-china-myanmar-border-reveals-little-regional-genetic-differentiation-of-plasmodium-vivax-populations
#8
Xiaotong Zhu, Pan Zhao, Si Wang, Fei Liu, Jun Liu, Jian Wang, Zhaoqing Yang, Guiyun Yan, Qi Fan, Yaming Cao, Liwang Cui
BACKGROUND: With the premise of diminishing parasite genetic diversity following the reduction of malaria incidence, the analysis of polymorphic antigenic markers may provide important information about the impact of malaria control on local parasite populations. Here we evaluated the genetic diversity of Plasmodium vivax apical membrane antigen 1 (Pvama1) gene in a parasite population from the China-Myanmar border and compared it with global P. vivax populations. METHODS: We performed evolutionary analysis to examine the genetic diversity, natural selection, and population differentiation of 73 Pvama1 sequences acquired from the China-Myanmar border as well as 615 publically available Pvama1 sequences from seven global P...
November 29, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27899111/plasmodium-malariae-in-the-colombian-amazon-region-you-don-t-diagnose-what-you-don-t-suspect
#9
Carlos Hernando Niño, Juan Ricardo Cubides, Paola Andrea Camargo-Ayala, Carlos Arturo Rodríguez-Celis, Teódulo Quiñones, Moisés Tomás Cortés-Castillo, Lizeth Sánchez-Suárez, Ricardo Sánchez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
BACKGROUND: Malaria is a worldwide public health problem; parasites from the genus Plasmodium spp. are the aetiological agent of this disease. The parasite is mainly diagnosed by microscope-based techniques. However, these have limited sensitivity. Many asymptomatic infections are sub-microscopic and can only be detected by molecular methods. This study was aimed at comparing nested PCR results to those obtained by microscope for diagnosing malaria and to present epidemiological data regarding malaria in Colombia's Amazon department...
November 29, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27895279/evaluation-of-immunoglobulin-g-responses-to-plasmodium-falciparum-and-plasmodium-vivax-in-malian-school-children-using-multiplex-bead-assay
#10
Eric Rogier, Delynn M Moss, Anna N Chard, Victoria Trinies, Seydou Doumbia, Matthew C Freeman, Patrick J Lammie
Malaria serology through assaying for IgG against Plasmodium spp. antigens provides evidence into the infection history for an individual. The multiplex bead assay (MBA) allows for detection of IgG against multiple Plasmodium spp., and can be especially useful in many regions where Plasmodium falciparum is of primary clinical focus, but other species are co-endemic. Dried blood spots were collected from 805 Malian children attending 42 elementary schools in the regions of Mopti, Sikasso, Koulikoro, and Bamako capital district, and IgG assayed by MBA...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27894375/plasmodium-knowlesi-and-human-malaria-parasites-in-khan-phu-vietnam-gametocyte-production-in-humans-and-frequent-co-infection-of-mosquitoes
#11
Y Maeno, R Culleton, N T Quang, S Kawai, R P Marchand, S Nakazawa
Four species of malaria parasite, Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium knowlesi infect humans living in the Khanh Phu commune, Khanh Hoa Province, Vietnam. The latter species also infects wild macaque monkeys in this region. In order to understand the transmission dynamics of the three species, we attempted to detect gametocytes of the three species in the blood of infected individuals, and sporozoites in the salivary glands of mosquitoes from the same region. For the detection of gametocyte-specific mRNA, we targeted region 3 of pfg377, pvs25, pmg and pks25 as indicators of the presence of P...
November 29, 2016: Parasitology
https://www.readbyqxmd.com/read/27894320/successful-malaria-elimination-in-the-ecuador-peru-border-region-epidemiology-and-lessons-learned
#12
Lyndsay K Krisher, Jesse Krisher, Mariano Ambuludi, Ana Arichabala, Efrain Beltrán-Ayala, Patricia Navarrete, Tania Ordoñez, Mark E Polhemus, Fernando Quintana, Rosemary Rochford, Mercy Silva, Juan Bazo, Anna M Stewart-Ibarra
BACKGROUND: In recent years, malaria (Plasmodium vivax and Plasmodium falciparum) has been successfully controlled in the Ecuador-Peru coastal border region. The aim of this study was to document this control effort and to identify the best practices and lessons learned that are applicable to malaria control and to other vector-borne diseases. A proximal outcome evaluation was conducted of the robust elimination programme in El Oro Province, Ecuador, and the Tumbes Region, Peru. Data collection efforts included a series of workshops with local public health experts who played central roles in the elimination effort, review of epidemiological records from Ministries of Health, and a review of national policy documents...
November 28, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27893347/asymptomatic-infections-in-blood-donors-harbouring-plasmodium-an-invisible-risk-detected-by-molecular-and-serological-tools
#13
Giselle F M C Lima, Maria C Arroyo Sanchez, José E Levi, Mahyumi Fujimori, Luiza Da Cruz Caramelo, Arianni Rondelli Sanchez, Eduardo M Ramos-Sanchez, Juliana Inoue, Maria De Jesus Costa-Nascimento, Alfredo Mendrone Junior, Silvia M Di Santi
BACKGROUND: Transfusion-transmitted malaria due to asymptomatic Plasmodium infections is a challenge for blood banks. There is a lack of data on the prevalence of asymptomatic infected blood donors and the incidence of transfusion-transmitted malaria in low endemicity areas worldwide. We estimated the frequency of blood donors harbouring Plasmodium in an area in which asymptomatic infections have been reported. MATERIAL AND METHODS: To estimate the frequency of blood donors harbouring Plasmodium we used microscopy and molecular tools...
November 7, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27884146/demographic-and-clinical-profiles-of-plasmodium-falciparum-and-plasmodium-vivax-patients-at-a-tertiary-care-centre-in-southwestern-india
#14
Laura Chery, Jennifer N Maki, Anjali Mascarenhas, Jayashri T Walke, Pooja Gawas, Anvily Almeida, Mezia Fernandes, Marina Vaz, Rakesh Ramanan, Diksha Shirodkar, Maria Bernabeu, Suresh Kumar Manoharan, Ligia Pereira, Rashmi Dash, Ambika Sharma, Riaz Basha Shaik, Rimi Chakrabarti, Prasad Babar, John White, Devaraja G Mudeppa, Shiva Kumar, Wenyun Zuo, Kristen M Skillman, Usheer Kanjee, Caeul Lim, Kathryn Shaw-Saliba, Ashwani Kumar, Neena Valecha, V N Jindal, Anar Khandeparkar, Pradeep Naik, Sunanda Amonkar, Manoj T Duraisingh, Shripad Tuljapurkar, Joseph D Smith, Nagesh Dubhashi, Roque G W Pinto, Maria Silveria, Edwin Gomes, Pradipsinh K Rathod
BACKGROUND: Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India. METHODS: A prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P...
November 25, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27881677/basigin-interacts-with-plasmodium-vivax-tryptophan-rich-antigen-pvtrag38-as-a-second-erythrocyte-receptor-to-promote-parasite-growth
#15
Sumit Rathore, Sheena Dass, Divya Kandari, Inderjeet Kaur, Mayank Gupta, Yagya D Sharma
Elucidating molecular mechanisms of host-parasite interaction during red cell invasion by Plasmodium is important to develop newer antimalarial therapeutics. Recently, we have characterized a Plasmodium vivax tryptophan-rich antigen PvTRAg38, which is expressed by its merozoites, binds to host erythrocytes, and interferes with the parasite growth. Interaction of this parasite ligand to the host erythrocyte occurs through its two regions present at amino acid positions 167-178 (P2) and 197-208 (P4). Each region recognizes its own erythrocyte receptor...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27879461/unstable-malaria-transmission-in-the-southern-peruvian-amazon-and-its-association-with-gold-mining-madre-de-dios-2001-2012
#16
Juan F Sanchez, Andres M Carnero, Esteban Rivera, Luis A Rosales, G Christian Baldeviano, Jorge L Asencios, Kimberly A Edgel, Joseph M Vinetz, Andres G Lescano
The reemergence of malaria in Madre de Dios, in the southern Peruvian Amazon basin, in the last decade was accompanied by ecological, political, and socioeconomic changes related to the proliferation of illegal gold mining. We conducted a secondary analysis of passive malaria surveillance data reported by the health networks in Madre de Dios between 2001 and 2012. We calculated the number of cases of malaria by year, geographic location, intensity of illegal mining activities, and proximity of health facilities to the Peru-Brazil Interoceanic Highway...
November 22, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27865203/minocycline-prevents-cerebral-malaria-confers-neuroprotection-and-increases-survivability-of-mice-during-plasmodium-berghei-anka-infection
#17
Thittayil Suresh Apoorv, Phanithi Prakash Babu
Cerebral malaria (CM) is a neurological complication arising due to Plasmodium falciparum or Plasmodium vivax infection. Minocycline, a semi-synthetic tetracycline, has been earlier reported to have a neuroprotective role in several neurodegenerative diseases. In this study, we investigated the effect of minocycline treatment on the survivability of mice during experimental cerebral malaria (ECM). The currently accepted mouse model, C57BL/6 mice infected with Plasmodium berghei ANKA, was used for the study...
November 16, 2016: Cytokine
https://www.readbyqxmd.com/read/27857147/molecular-mechanism-of-action-of-antimalarial-benzoisothiazolones-species-selective-inhibitors-of-the-plasmodium-spp-mep-pathway-enzyme-ispd
#18
Kathryn E Price, Christopher M Armstrong, Leah S Imlay, Dana M Hodge, C Pidathala, Natalie J Roberts, Jooyoung Park, Marwa Mikati, Raman Sharma, Alexandre S Lawrenson, Niraj H Tolia, Neil G Berry, Paul M O'Neill, Audrey R Odom John
The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d]isothiazol-3(2H)-ones as species-selective inhibitors of Plasmodium spp. 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (IspD), the third catalytic enzyme of the MEP pathway. 2-Phenyl benzo[d]isothiazol-3(2H)-ones display nanomolar inhibitory activity against P...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852258/allele-specific-antibodies-to-plasmodium-vivax-merozoite-surface-protein-1-prevalence-and-inverse-relationship-to-haemoglobin-levels-during-infection
#19
Nuno Sepúlveda, Cristiane Guimarães Morais, Luiza Carvalho Mourão, Matheus França Freire, Cor Jesus F Fontes, Marcus Vinícius G Lacerda, Chris J Drakeley, Érika Martins Braga
BACKGROUND: Antigenic polymorphisms are considered as one of the main strategies employed by malaria parasites to escape from the host immune responses after infections. Merozoite surface protein-1 (MSP-1) of Plasmodium vivax, a promising vaccine candidate, is a highly polymorphic protein whose immune recognition is not well understood. METHODS AND RESULTS: The IgG responses to conserved (MSP-119) and polymorphic (block 2 and block 10) epitopes of PvMSP-1 were evaluated in 141 P...
November 16, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27846879/plasmodium-malariae-and-plasmodium-ovale-infections-in-the-china-myanmar-border-area
#20
Peipei Li, Zhenjun Zhao, Hua Xing, Wenli Li, Xiaotong Zhu, Yaming Cao, Zhaoqing Yang, Jetsumon Sattabongkot, Guiyun Yan, Qi Fan, Liwang Cui
BACKGROUND: The Greater Mekong Subregion is aiming to achieve regional malaria elimination by 2030. Though a shift in malaria parasite species predominance by Plasmodium vivax has been recently documented, the transmission of the two minor Plasmodium species, Plasmodium malariae and Plasmodium ovale spp., is poorly characterized in the region. This study aims to determine the prevalence of these minor species in the China-Myanmar border area and their genetic diversity. METHODS: Epidemiology study was conducted during passive case detection in hospitals and clinics in Myanmar and four counties in China along the China-Myanmar border...
November 15, 2016: Malaria Journal
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