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Galactooligosaccharide

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https://www.readbyqxmd.com/read/29339290/biocatalytic-strategies-in-the-production-of-galacto-oligosaccharides-and-its-global-status
#1
REVIEW
Parmjit S Panesar, Rupinder Kaur, Ram S Singh, John F Kennedy
Galactooligosaccharides (GOSs) are the non-digestible carbohydrates that are composed of 3-10 or longer molecules of galactose and the terminal glucose molecule. These are considered as prebiotics owing to their various health benefits, and therefore is the major focus of research. These are generally synthesized by the catalytic activity of the glycoside hydrolases (GH) utilizing lactose as a substrate, which results in the mixture of GOSs differing in their degree of polymerization. Different microbial glycoside hydrolases have been used for the production...
January 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29333394/evaluation-of-anti-wrinkle-effects-of-duoligo-composed-of-lactulose-and-galactooligosaccharides
#2
Eun Young Jung, Jung Il Kwon, Yang Hee Hong, Hyung Joo Suh
Currently, alternatives to prebiotics for skin treatment are receiving much interest. However, little is known about the efficacy of topically applied prebiotics in skin anti-aging. This study was conducted to observe the anti-aging effects of DuOligo, which is composed of lactulose and galactooligosaccharides (GOS). We investigated wrinkle-related parameters by quantitative and qualitative skin evaluation in healthy women who consumed DuOligo for 8 weeks. The double-blind, randomized, and placebo-controlled study included subjects who were divided into two groups (Placebo: dextrin 4...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29258754/the-effects-of-dietary-supplement-of-galactooligosaccharide-on-innate-immunity-immune-related-genes-expression-and-growth-performance-in-zebrafish-danio-rerio
#3
Samira Yousefi, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradloo
The present study investigates the effect of different levels of galactooligosaccharide (GOS) on innate immune parameters, immune related genes expression as well as growth performance in zebrafish (Danio rerio). Four hundred and twenty fish (mean weight 45 ± 0.1 mg) were supplied, randomly stocked in twelve aquaria assigned to four treatments. Zebrafish were fed with either control diet or control diet enriched with different levels (0.5, 1 and 2%) of GOS for eight weeks. At the end of feeding trial innate immune parameters (total immunoglobulin, total protein and alkaline phosphatase activity), immune related genes expression (interleukin 1 beta [il1b], Lysozyme [lyz], tumor necrosis factor alpha [tnf-alpha]) as well as growth performance were measured...
December 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29251222/dietary-polydextrose-and-galactooligosaccharide-increase-exploratory-behavior-improve-recognition-memory-and-alter-neurochemistry-in-the-young-pig
#4
Stephen A Fleming, Supida Monaikul, Alexander J Patsavas, Rosaline V Waworuntu, Brian M Berg, Ryan N Dilger
OBJECTIVES: Previous studies have shown that dietary prebiotics have the potential to improve memory, alter social behavior, and reduce anxiety-like behaviors in rodents. The present research sought to expand upon such results and describe the effects of feeding prebiotics early in life on cognition and neurochemistry using a translational piglet model. METHODS: Pigs were provided customized milk replacer containing 2 g/L each of polydextrose (PDX) and galactooligosaccharide (PDX/GOS) or 0 g/L (Control) from postnatal day (PND) 2-33...
December 18, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29232851/a-novel-prebiotic-blend-product-prevents-irritable-bowel-syndrome-in-mice-by-improving-gut-microbiota-and-modulating-immune-response
#5
Qian Chen, Yiping Ren, Jihong Lu, Mark Bartlett, Lei Chen, Yan Zhang, Xiaokui Guo, Chang Liu
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder yet it still lacks effective prevention therapies. The aim of this study is to determine whether a novel prebiotic blend (PB) composed of fructo-oligosaccharide (FOS), galactooligosaccharide (GOS), inulin and anthocyanins could be effective in preventing the development of IBS. We explored the possible mechanisms both in animal and in cells. Post-infectious IBS models in C57BL/6 mice were established and were pretreated with the PB, PB and probiotic strains 8 weeks in advance of infection...
December 9, 2017: Nutrients
https://www.readbyqxmd.com/read/29181978/improving-the-secretion-yield-of-%C3%AE-galactosidase-bgal1-3-in-pichia-pastoris-as-a-potential-catalyst-for-the-production-of-prebiotic-enriched-milk
#6
Lichuang Cao, Guang-Hui Ren, Zongmin Qin, Xin Huang, Wei Kong, Zhi-Jun Wang, Weiqu Liang, Xiaogang Bi, Yuhuan Liu
In this study, three kinds of milk were treated with β-galactosidase Bgal1-3 (4 U/mL), resulting in 7.2-9.5 g/L galactooligosaccharides (GOS) at a lactose conversion of 90-95%. Then Bgal1-3 was secreted from Pichia pastoris X33 under the direction of α-factor signal peptide. After cultivation for 144 h in shake flask culture, the extracellular activity was 4.4 U/mL. Five more signal peptides (HFBI, apre, INU1A, MF4I and W1) were employed to direct the secretion, giving rise to a more efficient signal peptide W1 (11...
November 28, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29173065/neurobehavioural-effects-of-lactobacillus-rhamnosus-gg-alone-and-in-combination-with-prebiotics-polydextrose-and-galactooligosaccharide-in-male-rats-exposed-to-early-life-stress
#7
Karen-Anne McVey Neufeld, Siobhain M O'Mahony, Alan E Hoban, Rosaline V Waworuntu, Brian M Berg, Timothy G Dinan, John F Cryan
Early life is a period of significant brain development when the brain is at its most plastic and vulnerable. Stressful episodes during this window of development have long-lasting effects on the central nervous system. Rodent maternal separation (MS) is a reliable model of early-life stress and induces alterations in both physiology and behaviour. Intriguingly, the gut microbiota of MS offspring differ from that of non-separated offspring, suggesting a mechanistic role for the microbiota-gut-brain axis. Hence, we tested whether dietary factors known to affect the gut microbiota alter the neurobehavioural effects of MS...
November 27, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29168358/the-effect-of-early-administration-of-combined-multi-strain-and-multi-species-probiotics-on-gastrointestinal-morbidities-and-mortality-in-preterm-infants-a-randomized-controlled-trial-in-a-tertiary-care-unit
#8
İpek Güney-Varal, Nilgün Köksal, Hilal Özkan, Onur Bağcı, Pelin Doğan
Güney-Varal İ, Köksal N, Özkan H, Bağcı O, Doğan P. The effect of early administration of combined multi-strain and multi-species probiotics on gastrointestinal morbidities and mortality in preterm infants: A randomized controlled trial in a tertiary care unit. Turk J Pediatr 2017; 59: 13-19. Necrotizing enterocolitis (NEC) is a gastrointestinal emergency of the neonatal period. The aim of this study was to demonstrate the use of multistrain and multispecies probiotic on gastrointestinal morbidities and mortality...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29121496/properties-of-two-fungal-endo-%C3%AE-1-3-galactanases-and-their-synergistic-action-with-an-exo-%C3%AE-1-3-galactanase-in-degrading-arabinogalactan-proteins
#9
Yoshihisa Yoshimi, Kaori Yaguchi, Satoshi Kaneko, Yoichi Tsumuraya, Toshihisa Kotake
Arabinogalactan-proteins (AGPs) are plant proteoglycans, which are widely encountered in the plant kingdom, usually localized on the cell surface. The carbohydrate moieties of AGPs consist of β-1,3-galactan main chains and β-1,6-galactan side chains, to which other auxiliary sugars are attached. To date, FvEn3GAL isolated from Flammulina velutipes is the sole β-1,3-galactanase acting on β-1,3-galactan in an endo-manner. Here we cloned two homologous genes, designated Af3G and NcEn3GAL, possibly encoding endo-β-1,3-galactanase from Aspergillus flavus and Neurospora crassa, respectively...
October 25, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29032473/oligosaccharide-biotechnology-an-approach-of-prebiotic-revolution-on-the-industry
#10
REVIEW
Mario Cezar Rodrigues Mano, Iramaia Angélica Neri-Numa, Juliana Bueno da Silva, Bruno Nicolau Paulino, Marina Gabriel Pessoa, Gláucia Maria Pastore
Oligosaccharides are polymers with two to ten monosaccharide residues which have sweetener functions and sensory characteristics, in addition to exerting physiological effects on human health. The ones called nondigestible exhibit a prebiotic behavior being fermented by colonic microflora or stimulating the growth of beneficial bacteria, playing roles in the immune system, protecting against cancer, and preventing cardiovascular and metabolic issues. The global prebiotics market is expected to grow around 12...
October 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29030034/a-novel-polyacrylamide-based-silica-stationary-phase-for-the-separation-of-carbohydrates-using-alcohols-as-the-weak-eluent-in-hydrophilic-interaction-liquid-chromatography
#11
Jianfeng Cai, Lingping Cheng, Jianchao Zhao, Qing Fu, Yu Jin, Yanxiong Ke, Xinmiao Liang
A hydrophilic interaction liquid chromatography (HILIC) stationary phase was prepared by a two-step synthesis method, immobilizing polyacrylamide on silica sphere particles. The stationary phase (named PA, 5μm dia) was evaluated using a mixture of carbohydrates in HILIC mode and the column efficiency reached 121,000Nm(-1). The retention behavior of carbohydrates on PA stationary phase was investigated with three different organic solvents (acetonitrile, ethanol and methanol) employed as the weak eluent. The strongest hydrophilicity of PA stationary phase was observed in both acetonitrile and methanol as the weak eluent, when compared with another two amide stationary phases...
October 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28948579/effect-of-lactobacillus-rhamnosus-ncdc-298-with-fos-in-combination-on-viability-and-toxin-production-of-enterotoxigenic-escherichia-coli
#12
Santosh Anand, Surajit Mandal, Sudhir Kumar Tomar
The present study was to investigate the utilization of prebiotics by Lactobacillus rhamnosus NCDC 298 and its synergistic adversary effect on both population and production of heat-labile (LT) toxin in enterotoxigenic Escherichia coli (ETEC). To select suitable prebiotic in order to enhance functionality, its utilization and the prebiotic activity score was examined. Antivirulence effect on ETEC was inspected by its inactivation rate and heat-labile toxin production in presence of different synbiotic combination...
September 25, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28924143/fructooligosaccharide-fos-and-galactooligosaccharide-gos-increase-bifidobacterium-but-reduce-butyrate-producing-bacteria-with-adverse-glycemic-metabolism-in-healthy-young-population
#13
Feitong Liu, Pan Li, Muxuan Chen, Yuemei Luo, M Prabhakar, Huimin Zheng, Yan He, Qi Qi, Haoyu Long, Yi Zhang, Huafang Sheng, Hongwei Zhou
The gut microbiota has been implicated in glucose intolerance and its progression towards type-2 diabetes mellitus (T2DM). Relevant randomized clinical trial with prebiotic intervention was inadequate. We sought to evaluate the impact of fructooligosaccharides (FOS) and galactooligosaccharides (GOS) on glycemia during oral glucose tolerance test (OGTT) and intestinal microbiota. A randomized double-blind cross-over study was performed with 35 adults treated with FOS and GOS for 14 days (16 g/day). Faeces sampling, OGTT and anthropometric parameters were performed...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28920844/identification-of-genes-involved-in-galactooligosaccharide-utilization-in-bifidobacterium-breve-strain-yit-4014t
#14
Hidetsugu Sotoya, Akira Shigehisa, Taeko Hara, Hoshitaka Matsumoto, Hiroshi Hatano, Takahiro Matsuki
Galactooligosaccharides (GOS) are mixed oligosaccharides that are mainly composed of galactosyllactoses (GLs), which include 3'-GL, 4'-GL, and 6'-GL. Data from numerous in vitro and in vivo studies have shown that GOS selectively stimulate the growth of bifidobacteria. Previously, we identified the gene locus responsible for 4'-GL utilization, but the selective routes of uptake and catabolism of 3'- and 6'-GL remain to be elucidated. In this study, we used differential transcriptomics to identify the utilization pathways of these GLs within the Bifidobacterium breve YIT 4014T strain...
September 18, 2017: Microbiology
https://www.readbyqxmd.com/read/28917489/the-effects-of-single-or-combined-administration-of-galactooligosaccharide-and-pediococcus-acidilactici-on-cutaneous-mucus-immune-parameters-humoral-immune-responses-and-immune-related-genes-expression-in-common-carp-cyprinus-carpio-fingerlings
#15
Maryam Modanloo, Siyavash Soltanian, Mostafa Akhlaghi, Seyed Hossein Hoseinifar
The present study was performed to investigate the effects of single or combined administration of galactooligosaccharide (GOS) and Pediococcus acidilactici on cutaneous mucus immune parameters, humoral immune responses and immune related genes expression in common carp (Cyprinus carpio) fingerlings. Carps were fed experimental diets for 8 weeks as follows: non-supplemented (Control), prebiotic diet (10 g/kg GOS), probiotic diet (1 g/kg [0.9 × 10(7) CFU] lyophilized P. acidilactici) and synbiotic diet (10 GOS in combination with 1 g/kg [0...
September 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28894632/dietary-incorporation-of-whey-protein-isolate-and-galactooligosaccharides-exhibits-improvement-in-glucose-homeostasis-and-insulin-resistance-in-high-fat-diet-fed-mice
#16
Praveen Kumar Kavadi, Ramesh Pothuraju, Jayasimha Chagalamarri, Gaurav Bhakri, Aswani Mallepogu, Raj Kumar Sharma
BACKGROUND: This study was planned to investigate the effectiveness of the whey protein isolate (WPI) of high purity and a galactooligosaccharides (GOS) preparation on glucose homeostasis and insulin resistance in high fat diet (HFD) (45.47% energy from fat) fed conditions in C57BL/6J mice. METHODS: Fasting blood glucose level, serum insulin, and glucagon-like peptide-1 (enzyme-linked immunosorbent assay) were measured; also, homeostasis model assessment of insulin resistance (HOMA-IR) was determined in different treatment groups...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28840678/-pathomechanism-and-treatment-of-gut-microbiota-dysbiosis-in-chronic-kidney-disease-and-interventional-effects-of-chinese-herbal-medicine
#17
REVIEW
Wen-Bei Han, Ying-Lu Liu, Yi-Gang Wan, Wei Sun, Yue Tu, Jing-Jing Yang, Wei Wu, Wei-Ming He, Jian Yao
The gut microbiota dysbiosis is one of the risk factors in the progression from the advanced chronic kidney disease(CKD)to uremia, characterized by the reduction of probiotics and the increase of opportunistic pathogens including urease-related microbes, endotoxin-related microbes and toxin-related microbes, which can produce uremic toxins. According to the core point of "the gut-kidney axis" theory and "the chronic kidney disease-colonic axis" concept, the gut microbiota dysbiosis aggravates renal damage by accumulating uremic toxins and inducing the systemic micro-inflammation...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821142/manufacture-of-requeij%C3%A3-o-cremoso-processed-cheese-with-galactooligosaccharide
#18
P C Belsito, M V S Ferreira, L P Cappato, R N Cavalcanti, V A S Vidal, T C Pimentel, E A Esmerino, C F Balthazar, R P C Neto, M I B Tavares, P B Zacarchenco, M Q Freitas, M C Silva, R S L Raices, G M Pastore, M A R Pollonio, A G Cruz
The addition of galactooligosaccharide, (GOS, 0, 1.5, 3 or 4g/100g) on the quality parameters of requeijão cremoso was investigated. Chemical characteristics (pH, moisture, fat and protein), color (L*, a*, b*), water mobility by TD- nuclear magnetic resonance, rheology (flow curve and oscillatory tests), microstructure and sensory acceptance (consumer test) were evaluated. The addition of GOS provided a denser and compact structure and reduced number and size of fat globules. Increased GOS level (3 and 4g/100g) improved the softness and spreadability (decrease of G', G″ and apparent viscosity and an increase of tan δ and melting index) and impacted positively on the aroma and taste of the requeijão cremoso...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28793770/assessment-of-in-vitro-digestibility-of-dietary-carbohydrates-using-rat-small-intestinal-extract
#19
Alvaro Ferreira-Lazarte, Agustín Olano, Mar Villamiel, F Javier Moreno
There are few studies on the assessment of digestibility of nondigestible carbohydrates, despite their increasingly important role in human health. In vitro digestibility of a range of dietary carbohydrates classified as digestible (maltose, sucrose, and lactose), well-recognized (lactulose, fructooligosaccharides (FOS), and two types of galactooligosaccharides (GOS) differing in the predominant glycosidic linkage), and potential (lactosucrose and GOS from lactulose, OsLu) prebiotics using a rat small intestinal extract (RSIE) under physiological conditions of temperature and pH is described...
September 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28718519/cookies-elaborated-with-oat-and-common-bean-flours-improved-serum-markers-in-diabetic-rats
#20
Iza F Pérez-Ramírez, Laura J Becerril-Ocampo, Rosalía Reynoso-Camacho, Mayra Denise Herrera, S Horacio Guzmán-Maldonado, Raquel K Cruz-Bravo
BACKGROUND: Common beans have been associated to anti-diabetic effects, due to its high content of bioactive compounds. Nevertheless, its consumption has decreased worldwide. Therefore, there is an increasing interest in the development of novel functional foods elaborated with common beans. The aim of this study was to evaluate the anti-diabetic effect of oat-bean flour cookies, and to analyze its bioactive composition, using commercial oat-wheat cookies for comparative purposes. RESULTS: Oat-bean cookies (1...
July 17, 2017: Journal of the Science of Food and Agriculture
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