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Galactooligosaccharide

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https://www.readbyqxmd.com/read/29741241/a-method-of-early-phase-selection-of-carrier-for-aspergillus-oryzae-%C3%AE-galactosidase-immobilization-for-galactooligosaccharides-production
#1
Jana Adamíková, Monika Antošová, Milan Polakovič
Early-phase development of industrial immobilized biocatalysts has to address the selection of the best candidates from dozens of available carriers and binding methods. This work presents a simple selection method for the immobilization of industrial-grade Aspergillus oryzae β-galactosidase suitable for the production of galactooligosaccharides. Immobilization efficiency and yield of a variety of immobilized biocatalysts were evaluated using simple activity measurements and mathematical modelling of intraparticle kinetics and mass transfer...
May 9, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29731182/effect-of-probiotic-and-prebiotic-vs-placebo-on-psychological-outcomes-in-patients-with-major-depressive-disorder-a-randomized-clinical-trial
#2
Asma Kazemi, Ahmad Ali Noorbala, Kamal Azam, Mohammad Hadi Eskandari, Kurosh Djafarian
BACKGROUND: Disturbance in the equilibrium of the gut microbiota has been involved in the pathophysiology of depression. Probiotics have the potential to healthfully modulate the gut microbiome. Prebiotics could also be effective by stimulation of growth of some bacterial species in the gut microbiota. OBJECTIVE: The aim of this double blind clinical trial, was to compare the effect of supplementation with the probiotic and prebiotic on the Beck Depression Inventory (BDI) score as a primary outcome as well as the kynurenine/tryptophan ratio and tryptophan/branch chain amino acids (BCAAs) ratio as secondary outcomes in patients with major depressive disorder (MDD)...
April 24, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29700505/modifications-in-gut-microbiota-and-fermentation-metabolites-in-the-hindgut-of-rats-after-the-consumption-of-galactooligosaccharide-glycated-with-a-fish-peptide
#3
Weiya Jin, Kaining Han, Shiyuan Dong, Yuhong Yang, Zhenjie Mao, Mingyue Su, Mingyong Zeng
The aim of this research was to investigate the impact of a diet containing galactooligosaccharide (GOS)-fish peptide (FP) conjugates prepared via Maillard reaction on the colonic fermentation properties and the composition of gut microbiota in Sprague-Dawley rats. The rats were fed the GOS diet, FP diet, GOS and FP mixture (GOS/FP) diet, GOS glycated with FP (80 °C for 120 min, G-GOS/FP) diet, or control (CK) diet for three weeks. Compared to the GOS/FP diet, the G-GOS/FP diet greatly changed the pattern of SCFA production in the hindgut of rats, by increasing the total SCFA (44%), butyrate (55%) and propionate (1...
April 27, 2018: Food & Function
https://www.readbyqxmd.com/read/29680601/impact-of-ultrasound-on-galactooligosaccharides-and-gluconic-acid-production-throughout-a-multienzymatic-system
#4
Fabián Rico-Rodríguez, Juan Carlos Serrato, Antonia Montilla, Mar Villamiel
Galactooligosaccharides (GOS), recognised prebiotic, can be industrially produced from lactose and commercial β-galactosidase (β-gal) from Kluyveromyces lactis. Residual lactose and glucose limit GOS applications. To handle this problem, a multienzymatic system, with β-gal and glucose oxidase (Gox), was proposed to reduce glucose content in reaction media through its oxidation to gluconic acid (GA). Besides, ultrasound (US) probe effect over the multienzymatic system to produce GOS and GA has been evaluated...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29594273/the-impact-of-galactooligosaccharides-on-the-bioaccessibility-of-sterols-in-a-plant-sterol-enriched-beverage-adaptation-of-the-harmonized-infogest-digestion-method
#5
Virginia Blanco-Morales, Gabriel López-García, Antonio Cilla, Guadalupe Garcia-Llatas, Reyes Barberá, María Jesús Lagarda, Luis Manuel Sánchez-Siles, Amparo Alegría
The effect of the addition of galactooligosaccharides (GOS) on sterol bioaccessibility in three plant sterol (PS)-enriched milk-based fruit beverages (without GOS addition (MfB) and with 2.5 g (MfB-G2) and 5.0 g (MfB-G5) GOS per 250 mL) was evaluated after micellar gastrointestinal digestion. Cholesterol bioaccessibility was very similar among beverages, though a slight significant increase (from 80% to 85%) was observed by the addition of 5.0 g GOS. The addition of GOS did not affect total PS bioaccessibility (≈37%)...
March 29, 2018: Food & Function
https://www.readbyqxmd.com/read/29531228/understanding-the-prebiotic-potential-of-different-dietary-fibers-using-an-in-vitro-continuous-adult-fermentation-model-polyferms
#6
Sophie A Poeker, Annelies Geirnaert, Laura Berchtold, Anna Greppi, Lukasz Krych, Robert E Steinert, Tomas de Wouters, Christophe Lacroix
Consumption of fermentable dietary fibers (DFs), which can induce growth and/or activity of specific beneficial populations, is suggested a promising strategy to modulate the gut microbiota and restore health in microbiota-linked diseases. Until today, inulin and fructo-oligosaccharides (FOS) are the best studied DFs, while little is known about the gut microbiota-modulating effects of β-glucan, α-galactooligosaccharide (α-GOS) and xylo-oligosaccharide (XOS). Here, we used three continuous in vitro fermentation PolyFermS model to study the modulating effect of these DFs on two distinct human adult proximal colon microbiota, independently from the host...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29510254/the-functionality-of-prebiotics-as-immunostimulant-evidences-from-trials-on-terrestrial-and-aquatic-animals
#7
REVIEW
Asad Nawaz, Allah Bakhsh Javaid, Sana Irshad, Seyed Hossein Hoseinifar, Hanguo Xiong
The gut immune system is, the main option for maintaining host's health, affected by numerous factors comprising dietary constituents and commensal bacteria. These dietary components that affect the intestinal immunity and considered as an alternative of antibiotics are called immunosaccharides. Fructooligosaccharide (FOS), Galactooligosaccharide (GOS), inulin, dietary carbohydrates, and xylooligosaccharide (XOS) are among the most studied prebiotics in human as well as in aquaculture. Although prebiotics and probiotics have revealed potential as treatment for numerous illnesses in both human and fish, a comprehensive understanding of the molecular mechanism behind direct and indirect effect on the intestinal immune response will help more and perhaps extra effective therapy intended for ailments...
May 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29421696/purification-and-characterization-of-%C3%AE-galactosidase-from-probiotic-pediococcus-acidilactici-and-its-use-in-milk-lactose-hydrolysis-and-galactooligosaccharide-synthesis
#8
Preeti Chanalia, Dimpi Gandhi, Pooja Attri, Suman Dhanda
β-galactosidase is a commercially important enzyme that was purified from probiotic Pediococcus acidilactici. The enzyme was extracted from cells using sonication and subsequently purified using ammonium sulphate fractionation and successive chromatographies on Sephadex G-100 and Q-Sepharose. The enzyme was purified 3.06-fold up to electrophoretic homogeneity with specific activity of 0.883 U/mg and yield of 28.26%. Molecular mass of β-galactosidase as estimated by SDS-PAGE and MALDI-TOF was 39.07 kDa. The enzyme is a heterodimer with subunit mass of 15...
April 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29416857/glp1-and-gip-are-involved-in-the-action-of-synbiotics-in-broiler-chickens
#9
Pawel Antoni Kolodziejski, Maciej Sassek, Daniela Chalupka, Natalia Leciejewska, Leszek Nogowski, Pawel Mackowiak, Damian Jozefiak, Katarzyna Stadnicka, Maria Siwek, Marek Bednarczyk, Tomasz Szwaczkowski, Ewa Pruszynska-Oszmalek
Background: In order to discover new strategies to replace antibiotics in the post-antibiotic era in meat-type chicken production, two new synbiotics were tested: ( Lactobacillus salivarius IBB3154 plus galactooligosaccharide (Syn1) and Lactobacillus plantarum IBB3036 plus raffinose family oligosaccharides (Syn2). Methods: The synbiotics were administered via syringe, using a special automatic system, into the egg air chamber of Cobb 500 broiler chicks on the 12th day of egg incubation (2 mg of prebiotics + 105 cfu bacteria per egg)...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29363955/synthesis-of-stachyobifiose-using-bifidobacterial-%C3%AE-galactosidase-purified-from-recombinant-escherichia-coli
#10
So Young Oh, So Youn Youn, Myeong Soo Park, Nam In Baek, Geun Eog Ji
The prebiotic effects of GOS (galactooligosaccharides) are known to depend on the glycosidic linkages, degree of polymerization (DP), and the monosaccharide composition. In this study, a novel form of α-GOS with a potentially improved prebiotic effect was synthesized using bifidobacterial α-galactosidase (α-Gal) purified from recombinant Escherichia coli. The carbohydrate produced was identified as α-d-galactopyranosyl-(1→6)-O-α-d-glucopyranosyl-(1→2)-[α-d-galactopyranosyl-(1→6)-O-β-d-fructofuranoside] and was termed stachyobifiose...
February 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29339290/biocatalytic-strategies-in-the-production-of-galacto-oligosaccharides-and-its-global-status
#11
REVIEW
Parmjit S Panesar, Rupinder Kaur, Ram S Singh, John F Kennedy
Galactooligosaccharides (GOSs) are the non-digestible carbohydrates that are composed of 3-10 or longer molecules of galactose and the terminal glucose molecule. These are considered as prebiotics owing to their various health benefits, and therefore is the major focus of research. These are generally synthesized by the catalytic activity of the glycoside hydrolases (GH) utilizing lactose as a substrate, which results in the mixture of GOSs differing in their degree of polymerization. Different microbial glycoside hydrolases have been used for the production...
May 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29333394/evaluation-of-anti-wrinkle-effects-of-duoligo-composed-of-lactulose-and-galactooligosaccharides
#12
Eun Young Jung, Jung Il Kwon, Yang Hee Hong, Hyung Joo Suh
Currently, alternatives to prebiotics for skin treatment are receiving much interest. However, little is known about the efficacy of topically applied prebiotics in skin anti-aging. This study was conducted to observe the anti-aging effects of DuOligo, which is composed of lactulose and galactooligosaccharides (GOS). We investigated wrinkle-related parameters by quantitative and qualitative skin evaluation in healthy women who consumed DuOligo for 8 weeks. The double-blind, randomized, and placebo-controlled study included subjects who were divided into two groups (Placebo: dextrin 4...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29258754/the-effects-of-dietary-supplement-of-galactooligosaccharide-on-innate-immunity-immune-related-genes-expression-and-growth-performance-in-zebrafish-danio-rerio
#13
Samira Yousefi, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradloo
The present study investigates the effect of different levels of galactooligosaccharide (GOS) on innate immune parameters, immune related genes expression as well as growth performance in zebrafish (Danio rerio). Four hundred and twenty fish (mean weight 45 ± 0.1 mg) were supplied, randomly stocked in twelve aquaria assigned to four treatments. Zebrafish were fed with either control diet or control diet enriched with different levels (0.5, 1 and 2%) of GOS for eight weeks. At the end of feeding trial innate immune parameters (total immunoglobulin, total protein and alkaline phosphatase activity), immune related genes expression (interleukin 1 beta [il1b], Lysozyme [lyz], tumor necrosis factor alpha [tnf-alpha]) as well as growth performance were measured...
February 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29251222/dietary-polydextrose-and-galactooligosaccharide-increase-exploratory-behavior-improve-recognition-memory-and-alter-neurochemistry-in-the-young-pig
#14
Stephen A Fleming, Supida Monaikul, Alexander J Patsavas, Rosaline V Waworuntu, Brian M Berg, Ryan N Dilger
OBJECTIVES: Previous studies have shown that dietary prebiotics have the potential to improve memory, alter social behavior, and reduce anxiety-like behaviors in rodents. The present research sought to expand upon such results and describe the effects of feeding prebiotics early in life on cognition and neurochemistry using a translational piglet model. METHODS: Pigs were provided customized milk replacer containing 2 g/L each of polydextrose (PDX) and galactooligosaccharide (PDX/GOS) or 0 g/L (Control) from postnatal day (PND) 2-33...
December 18, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29232851/a-novel-prebiotic-blend-product-prevents-irritable-bowel-syndrome-in-mice-by-improving-gut-microbiota-and-modulating-immune-response
#15
Qian Chen, Yiping Ren, Jihong Lu, Mark Bartlett, Lei Chen, Yan Zhang, Xiaokui Guo, Chang Liu
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder yet it still lacks effective prevention therapies. The aim of this study is to determine whether a novel prebiotic blend (PB) composed of fructo-oligosaccharide (FOS), galactooligosaccharide (GOS), inulin and anthocyanins could be effective in preventing the development of IBS. We explored the possible mechanisms both in animal and in cells. Post-infectious IBS models in C57BL/6 mice were established and were pretreated with the PB, PB and probiotic strains 8 weeks in advance of infection...
December 9, 2017: Nutrients
https://www.readbyqxmd.com/read/29181978/improving-the-secretion-yield-of-the-%C3%AE-galactosidase-bgal1-3-in-pichia-pastoris-for-use-as-a-potential-catalyst-in-the-production-of-prebiotic-enriched-milk
#16
Lichuang Cao, Guanghui Ren, Zongmin Qin, Xin Huang, Wei Kong, Zhijun Wang, Weiqu Liang, Xiaogang Bi, Yuhuan Liu
In this study, three kinds of milk were treated with the β-galactosidase Bgal1-3 (4 U/mL), resulting in 7.2-9.5 g/L galactooligosaccharides (GOS) at a lactose conversion of 90-95%. Then, Bgal1-3 was secreted from Pichia pastoris X33 under the direction of an α-factor signal peptide. After cultivation for 144 h in a flask culture with shaking, the extracellular activity of Bgal1-3 was 4.4 U/mL. Five more signal peptides (HFBI, apre, INU1A, MF4I, and W1) were employed to direct the secretion, giving rise to a more efficient signal peptide, W1 (11...
December 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29173065/neurobehavioural-effects-of-lactobacillus-rhamnosus-gg-alone-and-in-combination-with-prebiotics-polydextrose-and-galactooligosaccharide-in-male-rats-exposed-to-early-life-stress
#17
Karen-Anne McVey Neufeld, Siobhain M O'Mahony, Alan E Hoban, Rosaline V Waworuntu, Brian M Berg, Timothy G Dinan, John F Cryan
Early life is a period of significant brain development when the brain is at its most plastic and vulnerable. Stressful episodes during this window of development have long-lasting effects on the central nervous system. Rodent maternal separation (MS) is a reliable model of early-life stress and induces alterations in both physiology and behaviour. Intriguingly, the gut microbiota of MS offspring differ from that of non-separated offspring, suggesting a mechanistic role for the microbiota-gut-brain axis. Hence, we tested whether dietary factors known to affect the gut microbiota alter the neurobehavioural effects of MS...
November 27, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29168358/the-effect-of-early-administration-of-combined-multi-strain-and-multi-species-probiotics-on-gastrointestinal-morbidities-and-mortality-in-preterm-infants-a-randomized-controlled-trial-in-a-tertiary-care-unit
#18
RANDOMIZED CONTROLLED TRIAL
İpek Güney-Varal, Nilgün Köksal, Hilal Özkan, Onur Bağcı, Pelin Doğan
Güney-Varal İ, Köksal N, Özkan H, Bağcı O, Doğan P. The effect of early administration of combined multi-strain and multi-species probiotics on gastrointestinal morbidities and mortality in preterm infants: A randomized controlled trial in a tertiary care unit. Turk J Pediatr 2017; 59: 13-19. Necrotizing enterocolitis (NEC) is a gastrointestinal emergency of the neonatal period. The aim of this study was to demonstrate the use of multistrain and multispecies probiotic on gastrointestinal morbidities and mortality...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29121496/properties-of-two-fungal-endo-%C3%AE-1-3-galactanases-and-their-synergistic-action-with-an-exo-%C3%AE-1-3-galactanase-in-degrading-arabinogalactan-proteins
#19
Yoshihisa Yoshimi, Kaori Yaguchi, Satoshi Kaneko, Yoichi Tsumuraya, Toshihisa Kotake
Arabinogalactan-proteins (AGPs) are plant proteoglycans, which are widely encountered in the plant kingdom, usually localized on the cell surface. The carbohydrate moieties of AGPs consist of β-1,3-galactan main chains and β-1,6-galactan side chains, to which other auxiliary sugars are attached. To date, FvEn3GAL isolated from Flammulina velutipes is the sole β-1,3-galactanase acting on β-1,3-galactan in an endo-manner. Here we cloned two homologous genes, designated Af3G and NcEn3GAL, possibly encoding endo-β-1,3-galactanase from Aspergillus flavus and Neurospora crassa, respectively...
October 25, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29032473/oligosaccharide-biotechnology-an-approach-of-prebiotic-revolution-on-the-industry
#20
REVIEW
Mario Cezar Rodrigues Mano, Iramaia Angélica Neri-Numa, Juliana Bueno da Silva, Bruno Nicolau Paulino, Marina Gabriel Pessoa, Gláucia Maria Pastore
Oligosaccharides are polymers with two to ten monosaccharide residues which have sweetener functions and sensory characteristics, in addition to exerting physiological effects on human health. The ones called nondigestible exhibit a prebiotic behavior being fermented by colonic microflora or stimulating the growth of beneficial bacteria, playing roles in the immune system, protecting against cancer, and preventing cardiovascular and metabolic issues. The global prebiotics market is expected to grow around 12...
January 2018: Applied Microbiology and Biotechnology
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