Rongyi Shi, Yiyi Wang, Ya Gao, Xiaoli Xu, Shuyu Mao, Yue Xiao, Shuang Song, Liangyan Wang, Bing Tian, Ye Zhao, Yuejin Hua, Hong Xu
Human flap endonuclease 1 (FEN1) is a structure-specific, multifunctional endonuclease essential for DNA replication and repair. Our previous study showed that in response to DNA damage, FEN1 interacts with the PCNA-like Rad9-Rad1-Hus1 complex instead of PCNA to engage in DNA repair activities, such as stalled DNA replication fork repair, and undergoes SUMOylation by SUMO-1. Here, we report that succinylation of FEN1 was stimulated in response to DNA replication fork-stalling agents, such as ultraviolet (UV) irradiation, hydroxyurea, camptothecin, and mitomycin C...
October 1, 2020: American Journal of Physiology. Cell Physiology