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Janette Mareska Rumbajan, Yuko Yamaguchi, Kazuhiko Nakabayashi, Ken Higashimoto, Hitomi Yatsuki, Kenichi Nishioka, Kentaro Matsuoka, Shigehisa Aoki, Shuji Toda, Satoru Takeda, Hiroyuki Seki, Izuho Hatada, Kenichiro Hata, Hidenobu Soejima, Keiichiro Joh
Aberrant DNA methylation is associated with a range of human disorders. To identify differences in DNA methylation of gene promoters between placentas of low-birth-weight (LBW) and normal-birth-weight (NBW) infants, we screened 8091 genes for aberrant methylation in placentas using microarray-based integrated analysis of methylation by isoschizomers (MIAMI). Seven candidate genes for hypomethylation in the placentas of LBW infants were selected. Among these candidates, COBRA analyses suggested that the HUS1B gene was hypomethylated in some of the placentas...
June 1, 2016: Gene
Guodong Teng, Chang Liu, Minliang Chen, Kui Ma, Liming Liang, Tongtong Yan
BACKGROUND: Hypertrophic scars (HSs) and keloids (KDs) are commonly seen as 2 different diseases. We aimed to find potential genes associated with KD and HS formation. METHODS: We selected 4 single-nucleotide polymorphisms (SNPs) (based on the whole genome resequencing we have done) for replication in 71 KDs and 50 HSs using the Sequenom Massarray system. RESULTS: We found evidence of significant association at rs181924090, P = 0.0075; rs183178644, P = 0...
January 2015: Annals of Plastic Surgery
Amy M Lyndaker, Ana Vasileva, Debra J Wolgemuth, Robert S Weiss, Howard B Lieberman
The RAD9A-RAD1-HUS1 (9-1-1) complex is a PCNA-like heterotrimeric clamp that binds damaged DNA to promote cell cycle checkpoint signaling and DNA repair. While various 9-1-1 functions in mammalian somatic cells have been established, mounting evidence from lower eukaryotes predicts critical roles in meiotic germ cells as well. This was investigated in 2 recent studies in which the 9-1-1 complex was disrupted specifically in the mouse male germline through conditional deletion of Rad9a or Hus1. Loss of these clamp subunits led to severely impaired fertility and meiotic defects, including faulty DNA double-strand break repair...
October 1, 2013: Cell Cycle
Vanessa M Dufault, Andrea J Oestreich, Benjamin T Vroman, Larry M Karnitz
RAD9 is an integral element of the PCNA-like HUS1-RAD1-RAD9 (9-1-1) complex that participates in genotoxin-induced CHK1 activation. We have identified a novel RAD9 paralog, dubbed RAD9B, in humans and mice. RAD9 and RAD9B share extensive amino acid homology throughout their entire sequences (36% identity, 48% similarity). Northern blotting revealed that RAD9B transcripts are highly expressed in human testes, with lower levels found in skeletal muscle. In contrast, RT-PCR analysis and immunoprecipitation demonstrated that RAD9B is also expressed in tumor cells...
December 2003: Genomics
Haiying Hang, Yuzhu Zhang, Roland L Dunbrack, Cuidong Wang, Howard B Lieberman
A paralog of the human cell cycle checkpoint gene HUS1 has been identified and designated HUS1B. It encodes a 278-amino-acid protein, 48% identical and 69% similar to HUS1. Mouse and rat orthologs of HUS1B have also been detected by a BLAST search. HUS1B is expressed variably in many human tissues, and the tissue-specific levels observed parallel those for HUS1. A HUS1-RAD1-RAD9 protein complex is thought to form a proliferating cell nuclear antigen (PCNA)-like structure, important for cell cycle checkpoint function...
April 2002: Genomics
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