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https://www.readbyqxmd.com/read/28432109/early-response-to-ranibizumab-predictive-of-functional-outcome-after-dexamethasone-for-unresponsive-diabetic-macular-oedema
#1
Maria Vittoria Cicinelli, Michele Cavalleri, Lea Querques, Alessandro Rabiolo, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyse the effects of intravitreal dexamethasone implant in patients suffering from diabetic macular oedema (DME) on the basis of their visual and functional response to antivascular endothelial growth factor (VEGF) loading dose, in order to early shift to corticosteroids in poorly responding patients. DESIGN: Retrospective monocentric study. METHODS: Data of patients with diabetes shifted to 0.7 mg dexamethasone implant after three injections of ranibizumab (RNB) and followed-up to 12 months were reviewed...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28428759/morphological-regeneration-and-functional-recovery-of-neuromuscular-junctions-after-tourniquet-induced-injuries-in-mouse-hindlimb
#2
Huiyin Tu, Dongze Zhang, Ryan M Corrick, Robert L Muelleman, Michael C Wadman, Yu-Long Li
Tourniquet application and its subsequent release cause serious injuries to the skeletal muscle, nerve, and neuromuscular junction (NMJ) due to mechanical compression and ischemia-reperfusion (IR). Monitoring structural and functional repair of the NMJ, nerve, and skeletal muscle after tourniquet-induced injuries is beneficial in exploring potential cellular and molecular mechanisms responsible for tourniquet-induced injuries, and for establishing effective therapeutic interventions. Here, we observed long-term morphological and functional changes of the NMJ in a murine model of tourniquet-induced hindlimb injuries...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28427119/-genetic-analysis-of-posterior-cranial-fossa-morphology-in-families-of-chiari-malformation-type-%C3%A2
#3
X X Yuan, Y Li, S F Sha, W X Sun, Y Qiu, Z Liu, W G Zhu, Z Z Zhu
Objective: To explore genetic characteristic of posterior cranial fossa morphology in families of Chiari malformation type Ⅰ (CMI). Methods: From April 2010 to May 2016, a total of 47 cases of CMI families (CMI group) and their 94 parents (CMI-P group)collected were retrospectively reviewed in Department of Spinal Surgery, Drum Tower Hospital, School of Medicine, Nanjing University.Another cohort of 50 asymptomatic adults was enrolled to serve as the control group.Patients with skull fracture or other diseases which can lead to secondary CMI were excluded...
April 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28419385/development-and-feasibility-of-a-group-based-therapeutic-yoga-program-for-women-with-chronic-pelvic-pain
#4
Alison J Huang, Tami S Rowen, Priscilla Abercrombie, Leslee L Subak, Michael Schembri, Traci Plaut, Maria T Chao
Objective.:  To develop a group-based therapeutic yoga program for women with chronic pelvic pain (CPP) and explore the effects of this program on pain severity, sexual function, and well-being. Methods.:  A yoga therapy program for CPP was developed by a multidisciplinary panel of clinicians, researchers, and yoga consultants. Women reporting moderate to severe pelvic pain for at least six months were recruited into a single-arm trial. Participants attended twice weekly group classes focusing on Iyengar-based yoga techniques and were instructed to practice yoga at home an hour a week for six weeks...
April 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28409669/treatment-of-thoracolumbar-burst-fractures-extended-follow-up-of-a-randomized-clinical-trial-comparing-orthosis-versus-no-orthosis
#5
Jennifer C Urquhart, Osama A Alrehaili, Charles G Fisher, Alyssa Fleming, Parham Rasoulinejad, Kevin Gurr, Stewart I Bailey, Fawaz Siddiqi, Christopher S Bailey
OBJECTIVE A multicenter, prospective, randomized equivalence trial comparing a thoracolumbosacral orthosis (TLSO) to no orthosis (NO) in the treatment of acute AO Type A3 thoracolumbar burst fractures was recently conducted and demonstrated that the two treatments following an otherwise similar management protocol are equivalent at 3 months postinjury. The purpose of the present study was to determine whether there was a difference in long-term clinical and radiographic outcomes between the patients treated with and those treated without a TLSO...
April 14, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28409655/9-1-1-triage-of-non-traumatic-chest-pain-association-with-hospital-diagnosis
#6
Greg Scott, Jeff J Clawson, Isabel Gardett, Meghan Broadbent, Nathan Williams, Conrad Fivaz, Gigi Marshall, Tracey Barron, Christopher Olola
OBJECTIVE: Chest pain is one of the most common reasons people seek emergency care-and one of the most critical. In the United States, chest pain is the second most common reason for emergency department (ED) visits. A patient's primary complaint of "chest pain" may reflect a broad range of underlying causes; therefore, it is important that emergency medical service (EMS) agencies gain a thorough understanding of these cases, beginning with the initial management of chest pain in the 9-1-1 center...
April 14, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28403885/lung-structure-and-function-similarities-between-primary-ciliary-dyskinesia-and-mild-cystic-fibrosis-a-pilot-study
#7
Marco Maglione, Silvia Montella, Carmine Mollica, Vincenzo Carnovale, Paola Iacotucci, Fabiola De Gregorio, Antonella Tosco, Mariarosaria Cervasio, Valeria Raia, Francesca Santamaria
BACKGROUND: Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) are increasingly compared. There are no chest magnetic resonance imaging (MRI) comparative studies of PCD and CF. We assessed clinical, functional, microbiological and MRI findings in PCD and mild CF patients in order to evaluate different expression of lung disease. METHODS: Twenty PCD (15.1 years) and 20 CF subjects with mild respiratory impairment (16 years, 70% with pancreatic insufficiency) underwent MRI, spirometry, and sputum cultures when clinically stable...
April 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28396998/operative-and-medical-treatment-of-chronic-anal-fissures-a-review-and-network-meta-analysis-of-randomized-controlled-trials
#8
REVIEW
Sabrina Maria Ebinger, Julia Hardt, René Warschkow, Bruno Martin Schmied, Alexander Herold, Stefan Post, Lukas Marti
Anal fissures are a common problem and have a cumulative lifetime incidence of 11%. Previous reviews on anal fissures show inconsistent results regarding post-interventional healing and incontinence rates. In this review our aim was to compare the treatments for chronic anal fissures by incorporating indirect comparisons using network meta-analysis. The PubMed database was searched for randomized controlled trials (RCTs) published between 1975 and 2015. The primary outcome measures were healing and incontinence rates after lateral internal sphincterotomy (LIS), anal dilatation (DILA), anoplasty and/or fissurectomy (FIAP), botulinum toxin (BT) and noninvasive treatment (NIT)...
April 10, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28389735/omitting-re-excision-for-focally-positive-margins-after-breast-conserving-surgery-does-not-impair-disease-free-and-overall-survival
#9
Elvira L Vos, Sabine Siesling, Margreet H A Baaijens, Cornelis Verhoef, Agnes Jager, Adri C Voogd, Linetta B Koppert
PURPOSE: In contrast to other countries, the Dutch breast cancer guideline does not recommend re-excision for focally positive margins after breast-conserving surgery (BCS) in invasive tumor and does recommend whole-breast irradiation including boost. We investigated whether omitting re-excision as compared to performing re-excision affects prognosis with a retrospective population-based cohort study. METHODS: The total cohort included 32,119 women with primary BCS for T1-T3 breast cancer diagnosed between 2003 and 2008 from the nationwide Netherlands cancer registry...
April 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28385638/barriers-to-patient-positioning-for-telephone-cardiopulmonary-resuscitation-in-out-of-hospital-cardiac-arrest
#10
Blake T Langlais, Micah Panczyk, John Sutter, Hidetada Fukushima, Zhixin Wu, Taku Iwami, Daniel Spaite, Bentley Bobrow
BACKGROUND: 9-1-1 callers often face barriers preventing them from starting Telephone CPR (TCPR). The most common problem is getting patients to a hard, flat surface. This study describes barriers callers report when trying to move patients to a hard, flat surface and assesses conditions associated with overcoming these barriers. METHODS: We audited 2,396 out-of-hospital cardiac arrest (OHCA) audio recordings. A barrier was defined as any statement by the caller that the rescuer could not move the patient to the ground and into a supine position...
April 3, 2017: Resuscitation
https://www.readbyqxmd.com/read/28381107/impaired-cognitive-performance-in-youth-athletes-exposed-to-repetitive-head-impacts
#11
Inga Katharina Koerte, Elizabeth Nichols, Yorghos Tripodis, Vivian Schultz, Stefan Lehner, Randy Igbinoba, Alice Z Chuang, Michael Mayinger, Eliana Klier, Marc Muehlmann, David Kaufmann, Christian Lepage, Florian Heinen, Gerd Schulte-Koerne, Ross D Zafonte, Martha E Shenton, Anne B Sereno
BACKGROUND: Worldwide more than 22 million children and adolescents are exposed to repetitive head impacts (RHI) in soccer. Evidence indicates cumulative effects on brain structure, but it is not known whether exposure to RHI affects cognitive improvement in adolescents. To determine whether exposure to RHI while heading the ball in soccer affects improvement in cognitive performance in adolescents over time. METHODS: The study group consisted of a convenience sample of 16 male soccer players (mean age 15...
April 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28380091/tear-osmolarity-and-ocular-surface-parameters-in-patients-with-psoriasis
#12
Goktug Demirci, Sevil Karaman Erdur, Rukiye Aydin, Ali Balevi, Mustafa Eliacik, Mustafa Ozsutcu, Oktay Olmuscelik
Purpose: The aim of this study was to evaluate tear osmolarity, tear film function, and ocular surface changes in patients with psoriasis. Methods: At a single center, 30 eyes of 30 patients with psoriasis (group 1) and 30 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT) test, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity measurement...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28378530/guided-bone-regeneration-with-particulate-vs-block-xenogenic-bone-substitutes-a-pilot-cone-beam-computed-tomographic-investigation
#13
Goran I Benic, Daniel S Thoma, Ronald E Jung, Ignacio M Sanz, Silvan Unger, Antonio Cantalapiedra, Christoph H F Hämmerle
AIM: To test whether an equine bone substitute block used for guided bone regeneration (GBR) of peri-implant defects differs from bovine block or particulate bone substitutes regarding the hard and soft tissue contours of the augmented ridge. MATERIAL & METHODS: Two semi-saddle bone defects were prepared in each side of the mandible of eight dogs, and one titanium implant was inserted into every defect. The defects were randomly allocated to receive one of the following treatments: bone augmentation by GBR using (1) particulate deproteinized bovine bone mineral (DBBM) + a collagen membrane (CM), (2) block DBBM + CM, (3) equine bone substitute block + CM, and (4) empty controls...
April 4, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28374295/windmill-flap-nipple-reduction-a-new-method-of-nipple-plasty
#14
Yijia Yu, Liyuan Wei, Yichen Shen, Wei Xiao, Jiaxin Huang, Jinghong Xu
BACKGROUND: Nipple hypertrophy is a common aesthetic issue for Asian women. Thus, methods to correct this problem are needed. Several nipple reduction procedures have been reported, but all have shortcomings. In this article, we propose a new method to reduce both the height and diameter of the nipple without affecting its function. METHODS: Sixteen female patients, between the ages of 24-41 years, underwent a new nipple reduction method in our department between May 17, 2010, and May 5, 2014...
April 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28368996/evaluation-of-angle-closure-as-a-risk-factor-for-reduced-corneal-endothelial-cell-density
#15
Varshini Varadaraj, Sabyasachi Sengupta, Krishnamurthy Palaniswamy, Kavitha Srinivasan, Mohideen A Kader, Ganesh Raman, Sharmila Reddy, Pradeep Y Ramulu, Rengaraj Venkatesh
PURPOSE: Acute angle closure attacks are frequently accompanied by corneal edema. However, little is known about corneal endothelial cell status at different stages of angle closure. Here, we compared endothelial cell density (ECD) in unoperated eyes with that in eyes with open angles (OAs) and various stages of angle closure disease. MATERIALS AND METHODS: The study was conducted at Aravind Eye Hospitals in India. Masked examiners performed gonioscopy to classify each eye as follows: (1) OA, (2) primary angle closure suspect, or (3) primary angle closure (PAC)/primary angle closure glaucoma (PACG)...
March 31, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28358282/efficacy-of-a-film-forming-medical-device-containing-sunscreen-50-and-piroxicam-0-8-in-actinic-keratosis-and-field-cancerization-a-multicenter-assessor-blinded-3-month-trial
#16
Mario Puviani, Chiara Galloni, Silvia Marchetti, Paolo Sergio Pavone, Silvia Lovati, Giuseppe Pistone, Valentina Caputo, Giovanna Tilotta, Giuseppe Scarcella, Elena Campione, Laura Diluvio, Virginia Garofalo, Luca Bianchi, Massimo Milani
INTRODUCTION: Sunscreen protection in subjects with actinic keratosis (AK) is highly recommended to prevent clinical evolution of this in situ skin cancer condition. Use of topical anti-cyclooxygenase drugs such as diclofenac and piroxicam reduces the number of lesions and improves the cancerization field. A film-forming medical device in a cream formulation containing organic and inorganic sun-filters (50+ SPF) and piroxicam 0.8% (ACTX) has shown in a pilot, single-center, open trial to reduce AK lesions improving the cancerization field...
April 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28351846/postural-heart-rate-changes-in-young-patients-with-vasovagal-syncope
#17
Marvin S Medow, Sana Merchant, Melissa Suggs, Courtney Terilli, Breige O'Donnell-Smith, Julian M Stewart
BACKGROUND AND OBJECTIVES: Recurrent postural vasovagal syncope (VVS) is caused by transient cerebral hypoperfusion from episodic hypotension and bradycardia; diagnosis is made by medical history. VVS contrasts with postural tachycardia syndrome (POTS), defined by chronic daily symptoms of orthostatic intolerance with excessive upright tachycardia without hypotension. POTS has recently been conflated with VVS when excessive tachycardia is succeeded by hypotension during tilt testing. We hypothesize that excessive tachycardia preceding hypotension and bradycardia is part of the vasovagal response during tilt testing of patients with VVS...
March 28, 2017: Pediatrics
https://www.readbyqxmd.com/read/28350656/an-update-on-the-anatomy-of-the-forehead-compartments
#18
Sebastian Cotofana, Asima Mian, Jonathan M Sykes, Wolfgang Redka-Swoboda, Andrea Ladinger, Tatjana Pavicic, Thilo L Schenck, Fahd Benslimane, Fabio Ingallina, Alexander Schlattau
BACKGROUND: The forehead is one of the most frequent locations for neuromodulator and soft tissue filler applications; however, the underlying anatomy is still poorly understood. Thus far, the presence of deep forehead compartments has not been confirmed. METHODS: Twenty Caucasian cephalic specimens, 15 fresh frozen (six female and nine male) and five with formalin-phenol embalmment (three female and two male) were investigated using contrast-enhanced computed tomographic scans, dye injections, and anatomical dissections...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28328296/the-relationship-between-metabolic-syndrome-its-components-and-dry-eye-a-cross-sectional-study
#19
Sevil Karaman Erdur, Rukiye Aydin, Mustafa Ozsutcu, Oktay Olmuscelik, Mustafa Eliacik, Goktug Demirci, Mehmet Selim Kocabora
PURPOSE: The aim of this study was to evaluate tear osmolarity and tear film function and ocular surface changes in patients with metabolic syndrome. METHODS: 108 eyes of 64 patients with metabolic syndrome (group 1) and 110 eyes of 55 healthy individuals (group 2) were included in this cross-sectional study. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT), and tear osmolarity...
March 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28327645/a-novel-point-of-care-smartphone-based-system-for-monitoring-the-cardiac-and-respiratory-systems
#20
Kwanghyun Sohn, Faisal M Merchant, Omid Sayadi, Dheeraj Puppala, Rajiv Doddamani, Ashish Sahani, Jagmeet P Singh, E Kevin Heist, Eric M Isselbacher, Antonis A Armoundas
Cardio-respiratory monitoring is one of the most demanding areas in the rapidly growing, mobile-device, based health care delivery. We developed a 12-lead smartphone-based electrocardiogram (ECG) acquisition and monitoring system (called "cvrPhone"), and an application to assess underlying ischemia, and estimate the respiration rate (RR) and tidal volume (TV) from analysis of electrocardiographic (ECG) signals only. During in-vivo swine studies (n = 6), 12-lead ECG signals were recorded at baseline and following coronary artery occlusion...
March 22, 2017: Scientific Reports
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