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https://www.readbyqxmd.com/read/28721135/a-comprehensive-guidelines-based-approach-reduces-cardiovascular-risk-in-everyday-practice-the-varo-study
#1
Tomáš Štulc, Věra Lánská, Michaela Šnejdrlová, Michal Vrablík, Martina Prusíková, Richard Češka
INTRODUCTION: The aim of study was to investigate the possibility of cardiovascular risk improvement through systematic identification of high-risk individuals and treatment in accordance with current guidelines using modern therapy in daily clinical practice. MATERIAL AND METHODS: Two hundred and sixty-three physicians participated in the study. The physicians were asked to screen for cardiovascular risk factors in patients presenting with unrelated problems and to re-evaluate the attainment of treatment goals in those with already known risk factors...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28721109/association-of-social-support-with-gratitude-and-sense-of-coherence-in-japanese-young-women-a-cross-sectional-study
#2
Tomoko Fujitani, Kumiko Ohara, Katsuyasu Kouda, Tomoki Mase, Chiemi Miyawaki, Katsumasa Momoi, Yoshimitsu Okita, Maki Furutani, Harunobu Nakamura
PURPOSE: Recent studies have shown that perceived social support is associated with gratitude and sense of coherence, but evidence for this concept remains scarce. In the present study, we investigated relationships between social support, gratitude, and sense of coherence, focusing on the construct of and source of social support among young women. METHODS: The study was conducted in 2014 in Japan. Participants comprised 208 female university students (aged 19...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28717922/healthy-living-behaviors-among-chinese-american-preschool-aged-children-results-of-a-parent-survey
#3
Virginia Rall Chomitz, Alison Brown, Victoria Lee, Aviva Must, Kenneth Kwan Ho Chui
Associations between diet, physical activity, parenting, and acculturation among Chinese-American children are understudied. Parents/caregivers of children attending child-care programs in Boston Chinatown completed a self-administered survey on demographics, child's diet, physical activities, anthropometrics, and parenting practices. Associations were evaluated in multivariable regression analysis, stratified by survey language preference, a proxy for acculturation. Responding Asian families = 132; 86...
July 17, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28696231/comparison-of-plasma-and-intrapulmonary-concentrations-of-nafithromycin-wck-4873-in-healthy-adult-subjects
#4
Keith A Rodvold, Mark H Gotfried, Rakesh Chugh, Mugdha Gupta, H David Friedland, Ashima Bhatia
Nafithromycin concentrations in plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) of 37 healthy adult subjects were measured following repeated dosing of oral nafithromycin 800 mg once daily for three days. Noncompartmental pharmacokinetic (PK) parameters were determined from serial plasma samples collected over a 24-hour interval following the first and third oral doses. Each subject underwent one standardized bronchoscopy with bronchoalveolar lavage (BAL) at 3, 6, 9, 12, 24 or 48 hours after the third dose of nafithromycin...
July 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28687420/hepatic-adverse-event-profile-of-inotuzumab-ozogamicin-in-adult-patients-with-relapsed-or-refractory-acute-lymphoblastic-leukaemia-results-from-the-open-label-randomised-phase-3-ino-vate-study
#5
Hagop M Kantarjian, Daniel J DeAngelo, Anjali S Advani, Matthias Stelljes, Partow Kebriaei, Ryan D Cassaday, Akil A Merchant, Naohito Fujishima, Toshiki Uchida, Maria Calbacho, Anna A Ejduk, Susan M O'Brien, Elias J Jabbour, Hui Zhang, Barbara J Sleight, Erik R Vandendries, David I Marks
BACKGROUND: The INO-VATE study demonstrated efficacy and safety of inotuzumab ozogamicin versus standard care in adults with relapsed or refractory B-cell acute lymphoblastic leukaemia. Here, we report the frequency of, and potential risk factors for, hepatotoxicity in patients in this trial and after treatment and subsequent haemopoietic stem-cell transplantation (HSCT). METHODS: In this open-label, phase 3, multicentre, international study, adults with relapsed or refractory, CD22-positive, Philadelphia chromosome (Ph)-positive or Ph-negative B-cell acute lymphoblastic leukaemia who were due to receive first or second salvage treatment were randomly assigned (1:1) via an interactive voice response system to receive inotuzumab ozogamicin (starting dose 1·8 mg/m(2) per cycle [0·8 mg/m(2) on day 1; 0·5 mg/m(2) on days 8 and 15 of a 21-28 day cycle for ≤6 cycles]) or standard care (either fludarabine plus cytarabine plus granulocyte colony-stimulating factor, mitoxantrone plus cytarabine, or high-dose cytarabine)...
July 4, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28681645/mean-platelet-volume-in-pemphigus-vulgaris
#6
Khalaf Kridin, Wesal Shihade, Shira Zelber-Sagi
Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. The mean platelet volume (MPV) is an index of platelet activation reported to be influenced by inflammation. We investigated the MPV in patients with PV relative to controls. This case-control study included 160 patients with PV and 640 age- and sex-matched controls. The MPV, platelet count, and other inflammatory parameters were measured for all study participants. A significantly decreased MPV was observed in patients with PV compared with controls, 9...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28678305/clinical-features-and-surgical-outcome-of-triad-exotropia
#7
Suk-Gyu Ha, Young-Woo Suh, Seung-Hyun Kim
PURPOSE: To describe the clinical features and surgical outcome of A-pattern exotropia combined with dissociated vertical deviation and superior oblique overaction. METHODS: The medical records of patients with A-pattern exotropia combined with dissociated vertical deviation and superior oblique overaction who underwent horizontal muscle surgery alone or in combination with superior oblique muscle weakening surgery were retrospectively reviewed. The patients were divided into two groups according to their surgery: the horizontal muscle surgery alone group and the horizontal muscle surgery with bilateral superior oblique weakening surgery (combined surgery) group...
July 5, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28674076/prevalence-of-and-risk-factors-for-diabetic-peripheral-neuropathy-in-youth-with-type-1-and-type-2-diabetes-search-for-diabetes-in-youth-study
#8
Mamta Jaiswal, Jasmin Divers, Dana Dabelea, Scott Isom, Ronny A Bell, Catherine L Martin, David J Pettitt, Sharon Saydah, Catherine Pihoker, Debra A Standiford, Lawrence M Dolan, Santica Marcovina, Barbara Linder, Angela D Liese, Rodica Pop-Busui, Eva L Feldman
OBJECTIVE: We assessed the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) enrolled in the SEARCH for Diabetes in Youth study. RESEARCH DESIGN AND METHODS: The Michigan Neuropathy Screening Instrument (MNSI) was used to assess DPN in 1,734 youth with T1D (age 18 ± 4 years, T1D duration 7.2 ± 1.2 years, and HbA1c 9.1 ± 1.9%) and 258 youth with T2D (age 22.0 ± 3.5 years, T2D duration 7...
July 3, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28669111/iopamidol-as-an-oral-contrast-media%C3%A2-for-computed-tomography-a-taste-comparison-to-iohexol-diatrizoate-sodium-and-barium-sulfate
#9
Douglas Rogers, Chandni Sheth, Laura Eisenmenger, Eugene Mignogna, Thomas Winter
OBJECTIVES: The objective of this study is to compare the palatability of iopamidol and iohexol. METHODS: This was a blinded and randomized trial in which fifty healthy subjects taste tested iopamidol (Isovue, Bracco Diagnostics), iohexol (Omnipaque, GE Healthcare), diatrizoate meglumine and diatrizoate sodium solution (Gastrografin, Bracco Diagnostics), and barium sulfate suspension 2.1% w/v, 2.0% w/w (READI-CAT2, E-Z-EM). Participants scored palatability on a continuous scale from 0 to 40 (0 = intolerable, 10 = unpleasant but tolerable, 20 = neutral, 30 = kind of like, 40 = strongly like)...
July 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28668839/evaluation-of-natriuretic-peptide-in-non-small-cell-lung-cancer-patients-treated-with-bevacizumab-together-with-carboplatin-paclitaxel-a-prospective-study
#10
Tomoyuki Otsuka, Takashi Nojiri, Seigo Minami, Hiroshi Hosoda, Muneyoshi Kuroyama, Haruhiko Hirata, Kaori Nakanishi, Suguru Yamamoto, Kiyoshi Komuta, Kenji Kangawa, Takashi Kijima
AIM: To identify predictive markers for efficacy of combination bevacizumab and carboplatin-paclitaxel treatment in patients with advanced non-squamous non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Twenty patients received carboplatin (area under the concentration-time curve (AUC) 6 mg/ml×min) and paclitaxel (200 mg/m(2)) with bevacizumab (15 mg/kg) on day 1 of a 21-day cycle. After four cycles of induction therapy, patients received bevacizumab maintenance therapy until disease progression or unacceptable toxicity occurred...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28666868/the-polyanionic-c-terminal-tail-of-human-rad17-regulates-interaction-with-the-9-1-1-complex
#11
Yasunori Fukumoto, Yuji Nakayama, Naoto Yamaguchi
In the activation and maintenance of ATR-dependent DNA damage checkpoint, the interaction between the Rad17-RFC2-5 and 9-1-1 complexes is essential, however, the regulatory mechanism of the interaction is not known. Here we show that vertebrate Rad17 proteins contain a polyanionic 12-amino acid sequence in the C-terminal ends that is important for the 9-1-1 interaction. We demonstrate that the C-terminal tail contains a conserved sequence designated iVERGE that must be intact for the 9-1-1 interaction and contains potential posttranslational modification sites...
June 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28661784/identifying-key-words-in-9-1-1-calls-for-stroke-a-mixed-methods-approach
#12
Christopher T Richards, Baiyang Wang, Eddie Markul, Frank Albarran, Doreen Rottman, Neelum T Aggarwal, Patricia Lindeman, Leslee Stein-Spencer, Joseph M Weber, Kenneth S Pearlman, Katie L Tataris, Jane L Holl, Diego Klabjan, Shyam Prabhakaran
OBJECTIVES: Identifying stroke during a 9-1-1 call is critical to timely prehospital care. However, emergency medical dispatchers (EMDs) recognize stroke in less than half of 9-1-1 calls, potentially due to the words used by callers to communicate stroke signs and symptoms. We hypothesized that callers do not typically use words and phrases considered to be classical descriptors of stroke, such as focal neurologic deficits, but that a mixed-methods approach can identify words and phrases commonly used by 9-1-1 callers to describe acute stroke victims...
June 29, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28660719/a-community-health-worker-delivered-intervention-in-african-american-women-with-type-2-diabetes-a-12-month-randomized-trial
#13
Lesley D Lutes, Doyle M Cummings, Kerry Littlewood, Emily Dinatale, Bertha Hambidge
OBJECTIVE: To evaluate the effectiveness of a community health worker (CHW)-delivered lifestyle intervention for African American women with type 2 diabetes. METHODS: Participants were randomized to either 16 phone-based lifestyle intervention sessions aimed at making small changes in their diet and activity or 16 educational mailings sent across 12 months. Main outcomes included glycosylated hemoglobin (HbA1c), blood pressure (BP), and weight (kg) changes. RESULTS: Two hundred middle-aged (mean = 53 ± 10...
June 29, 2017: Obesity
https://www.readbyqxmd.com/read/28657843/interreader-agreement-of-prostate-imaging-reporting-and-data-system-version-2-using-an-in-bore-mri-guided-prostate-biopsy-cohort-a-single-institution-s-initial-experience
#14
Daniel I Glazer, William W Mayo-Smith, Nisha I Sainani, Cheryl A Sadow, Mark G Vangel, Clare M Tempany, Ruth M Dunne
OBJECTIVE: The purpose of this study is to determine the interobserver agreement of the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) for diagnosing prostate cancer using in-bore MRI-guided prostate biopsy as the reference standard. MATERIALS AND METHODS: Fifty-nine patients underwent in-bore MRI-guided prostate biopsy between January 21, 2010, and August 21, 2013, and underwent diagnostic multiparametric MRI 6 months or less before biopsy. A single index lesion per patient was selected after retrospective review of MR images...
June 28, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28657819/cares-a-community-wide-collaboration-identifies-super-utilizers-and-reduces-their-9-1-1-call-emergency-department-and-hospital-visit-rates
#15
E Stein Bronsky, Constance McGraw, Robin Johnson, Kristin Giordano, Alessandro Orlando, David Bar-Or
BACKGROUND: A subset of individuals who inefficiently and frequently use emergency department (ED) services are called "super-utilizers." Our healthcare system is fragmented and complex, making it difficult for providers to identify super-utilizers and address their wide range of health issues. OBJECTIVE: The objective of our study was to evaluate a novel community-wide collaboration program called CARES (Community Assistance Referral and Education Services) designed to identify super-utilizers through local partnering organizations...
June 28, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28657800/effects-of-emergency-medical-services-agency-ownership-status-on-patient-transport
#16
Jackson Déziel
OBJECTIVES: Medical insurers have clearly defined which ambulance services will be reimbursed and which will not. Thus, ambulance agencies that provide emergency 9-1-1 services must be highly cognizant of their organization's revenue needs. This presents a distinction between publicly funded and privately funded organizations. This study seeks to identify any differences in the transport decision among agency ownership types. METHODS: This retrospective study captured all 9-1-1 ambulance requests in the state of Virginia for the years 2009 through 2013...
June 28, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28655940/evaluating-the-effects-of-air-pollution-from-a-plastic-recycling-facility-on-the-health-of-nearby-residents
#17
Zhao Xin, Toshihide Tsuda, Hiroyuki Doi
We evaluated how exposure to airborne volatile organic compounds emitted from a plastic recycling facility affected nearby residents, in a cross-sectional study. Individuals>10 years old were randomly sampled from 50 households at five sites and given questionnaires to complete. We categorized the subjects by distance from the recycling facility and used this as a proxy measure for pollutant exposure. We sought to improve on a preceding study by generating new findings, improving methods for questionnaire distribution and collection, and refining site selection...
June 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28655080/-a-retrospective-controlled-clinical-study-of-single-incision-plus-one-port-laparoscopic-surgery-for-sigmoid-colon-and-upper-rectal-cancer
#18
G X Li, J M Li, Y N Wang, H J Deng, T Y Mou, H Liu
Objective: To evaluate the short-term and oncologic outcomes of single-incision plus one port laparoscopic surgery (SILS+ 1) for sigmoid colon and upper rectal cancer. Methods: The clinic data of 46 patients with sigmoid colon and upper rectal cancer underwent SILS+ 1 at Department of General Surgery, Nanfang Hospital, Southern Medical University from September 2013 to September 2014 were retrospectively reviewed (SILS+ 1 group). After generating 1∶1 ration propensity scores given the covariates of age, gender, body mass index, American Society of Anesthesiologists score, surgeons, tumor location, the distance of tumor from anal, tumor diameter, and pathologic TNM stage, 46 patients with sigmoid colon and upper rectal cancer underwent conventional laparoscopic surgery (CLS) in the same time were matched as CLS group...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28652814/return-to-work-for-patients-with-diffuse-large-b-cell-lymphoma-and-transformed-indolent-lymphoma-undergoing-autologous-stem-cell-transplantation
#19
Bente Arboe, Maja Halgren Olsen, Jette Soenderskov Goerloev, Anne Katrine Duun-Henriksen, Christoffer Johansen, Susanne Oksbjerg Dalton, Peter de Nully Brown
BACKGROUND: Autologous stem cell transplantation (ASCT) is the standard treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL) or transformed indolent lymphoma (TIL). The treatment is mainly considered for younger patients still available for the work market. In this study, social outcomes after ASCT in terms of return to work (RTW) are described. PATIENTS AND METHODS: Information from national administrative registers was combined with clinical information on patients, who received ASCT for relapse of DLBCL or TIL between 2000 and 2012...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28652670/satisfaction-with-and-adherence-to-warfarin-treatment-a-cross-sectional-study-among-sudanese-patients
#20
Tarig Yousif Mohamed Eltayeb, Malik Suliman Mohamed, Abubaker Ibrahim Elbur, Ahmed Sayed Ahmed Elsayed
BACKGROUND: Satisfaction with and adherence to oral anticoagulant treatment are important measures that decrease morbidity and mortality. Higher satisfaction and adherence to warfarin therapy was found to be associated among other factors with good International Normalized Ratio (INR) control. OBJECTIVES: To assess patient satisfaction with and adherence to oral anticoagulant therapy and to identify predictors of the two studied domains. METHODS: A cross-sectional study was conducted at the Cardiothoracic Clinic in Alshaab Teaching Hospital; Khartoum; Sudan during March-April 2015...
July 2017: Journal of the Saudi Heart Association
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