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https://www.readbyqxmd.com/read/28107276/the-effect-of-deep-versus-moderate-neuromuscular-block-on-surgical-conditions-and-postoperative-respiratory-function-in-bariatric-laparoscopic-surgery-a-randomized-double-blind-clinical-trial
#1
Sam Baete, Gerd Vercruysse, Margot Vander Laenen, Pieter De Vooght, Jeroen Van Melkebeek, Dimitri Dylst, Maud Beran, Jan Van Zundert, René Heylen, Willem Boer, Sam Van Boxstael, Tom Fret, Hans Verhelst, Cathy De Deyne, Frank Jans, Pascal Vanelderen
BACKGROUND: In recent literature, it has been suggested that deep neuromuscular block (NMB) improves surgical conditions during laparoscopy; however, the evidence supporting this statement is limited, and this was not investigated in laparoscopic bariatric surgery. Moreover, residual NMB could impair postoperative respiratory function. We tested the hypotheses that deep NMB could improve the quality of surgical conditions for laparoscopic bariatric surgery compared with moderate NMB and investigated whether deep NMB puts patients at risk for postoperative respiratory impairment compared with moderate NMB...
January 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28105624/-clinical-research-of-delta-shaped-anastomosis-technology-in-laparoscopic-distal-gastrectomy-and-digestive-tract-reconstruction
#2
Bo Gao, Qingxing Huang, Jianhong Dong
OBJECTIVE: To evaluate the feasibility and safety of the delta-shaped anastomosis in laparoscopic distal gastrectomy and digestive tract reconstruction. METHODS: Clinical data of 34 gastric cancer patients undergoing laparoscopic distal gastrectomy with the delta-shaped anastomosis for digestive tract reconstruction (delta-shaped group) and 83 gastric cancer patients undergoing laparoscopic distal gastrectomy with Billroth I( for digestive tract reconstruction (Billroth group) by same surgeon team from July 2013 to July 2015 at the Department of Digestive Surgery, Affiliated Tumor Hospital of Shanxi Medical University were retrospectively analyzed...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28099695/low-maternal-pregnancy-associated-plasma-protein-a-during-the-first-trimester-of-pregnancy-and-pregnancy-outcomes
#3
Marja Kaijomaa, Leena Rahkonen, Veli-Matti Ulander, Esa Hämäläinen, Henrik Alfthan, Helene Markkanen, Seppo Heinonen, Vedran Stefanovic
OBJECTIVE: To assess the association between pregnancy-associated placental protein A (PAPP-A) levels in the first trimester of pregnancy and adverse pregnancy outcomes. METHOD: A retrospective study included data from a group of patients in the first trimester of pregnancy with PAPP-A levels below 0.3 multiples of median who attended the Helsinki University Hospital, Finland, between January 1, 2009 and December 31, 2012; an age-matched control group of patients with PAPP-A levels 0...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28097762/time-delays-in-the-diagnosis-and-treatment-of-fabry-disease
#4
Ricardo Reisin, Amandine Perrin, Pablo García-Pavía
BACKGROUND: The high variability in clinical manifestations of Fabry disease can lead to delays between symptom onset and correct diagnosis, and between correct diagnosis and initiation of enzyme replacement therapy. We investigated whether these delays have improved in recent years. METHODS: Data were analysed from the Fabry Outcome Survey (FOS; Shire; extracted August 2013) for "index patients", defined as the first patient diagnosed with Fabry disease from a family with several or no additional members registered in FOS...
January 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28097503/blended-chitosan-paste-for-infection-prevention-preliminary-and-preclinical-evaluations
#5
Joel M Berretta, Jessica A Jennings, Harry S Courtney, Karen E Beenken, Mark S Smeltzer, Warren O Haggard
BACKGROUND: Local drug delivery devices offer a promising method for delivering vancomycin and amikacin for musculoskeletal wounds. However, current local delivery devices such as beads and sponges do not necessarily allow for full coverage of a wound surface with eluted antibiotics and do not address the need for reducing the antibiotic diffusion distance to help prevent contamination by bacteria or other microorganisms. We blended chitosan/polyethylene glycol (PEG) pastes/sponges to increase biocompatibility and improve antibiotic coverage within the wound...
January 17, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28088413/short-communication-associations-between-feed-push-up-frequency-feeding-and-lying-behavior-and-milk-yield-and-composition-of-dairy-cows
#6
E K Miller-Cushon, T J DeVries
Feeding management factors have great potential to influence activity patterns and feeding behavior of dairy cows, which may have implications for performance. The objectives of this study were to assess the effects of feed push-up frequency on the behavioral patterns of dairy cows, and to determine associations between behavior and milk yield and composition. Lactating Holstein dairy cows (n = 28, parity = 1.9 ± 1.1; mean ± SD) were housed in tiestalls, milked twice per day, and offered ad libitum access to water and a total mixed ration (containing, on a dry matter basis: 25% corn silage, 25% grass/alfalfa haylage, 30% high-moisture corn, and 20% protein/mineral supplement), provided twice per day...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28063882/mice-lacking-grip1-2-show-increased-social-interactions-and-enhanced-phosphorylation-at-glua2-s880
#7
Mei Han, Rebeca Mejias, Shu-Ling Chiu, Rebecca Rose, Abby Adamczyk, Richard Huganir, Tao Wang
Glutamate receptor interacting proteins 1 and 2 (GRIP1/2) play an important role in regulating synaptic trafficking of AMPA receptor 2/3 (GluA2/3) and synaptic strength. Gain-of-function GRIP1 mutations are implicated in social behavioral deficits in autism. To study mechanisms of Grip1/2-mediated AMPA signaling in the regulation of social behaviors, we performed social behavioral testing on neuron-specific Grip1/2-double knockout (DKO) and wild type (WT) mice that are matched for age, sex, and strain background...
January 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28063255/targeting-of-the-fun30-nucleosome-remodeller-by-the-dpb11-scaffold-facilitates-cell-cycle-regulated-dna-end-resection
#8
Susanne Cs Bantele, Pedro Ferreira, Dalia Gritenaite, Dominik Boos, Boris Pfander
DNA double strand breaks (DSBs) can be repaired by either recombination-based or direct ligation-based mechanisms. Pathway choice is made at the level of DNA end resection, a nucleolytic processing step, which primes DSBs for repair by recombination. Resection is thus under cell cycle control, but additionally regulated by chromatin and nucleosome remodellers. Here we show that both layers of control converge in the regulation of resection by the evolutionarily conserved Fun30/SMARCAD1 remodeller. Yeast Fun30 and human SMARCAD1 are cell cycle-regulated by interaction with the DSB-localized scaffold proteins Dpb11 and TOPBP1, respectively...
January 7, 2017: ELife
https://www.readbyqxmd.com/read/28056435/measuring-women-s-experience-of-induction-of-labor-using-prostaglandin-vaginal-gel
#9
Michael Beckmann, Rachel Thompson, Yvette Miller, Samantha J Prosser, Vicki Flenady, Sailesh Kumar
OBJECTIVE: To describe and examine the EXIT (EXperiences of Induction Tool), and report on the experience of women undergoing PGE2 vaginal gel IOL, who were participants in a randomized controlled trial comparing early amniotomy with repeat-PGE2. STUDY DESIGN: Following an evening dose of PGE2 vaginal gel, 245 women with live singleton term pregnancies were randomized to amniotomy or repeat-PGE2. Women's experience of IOL was a secondary outcome measure, assessed using the self-report EXIT administered by phone at 7-9days post-partum...
December 28, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28055249/volumetry-of-the-dominant-intraprostatic-tumour-lesion-intersequence-and-interobserver-differences-on-multiparametric-mri
#10
Hugh Harvey, Matthew R Orton, Veronica A Morgan, Chris Parker, David Dearnaley, Cyril Fisher, Nandita M deSouza
OBJECTIVES: To establish interobserver reproducibility of tumour volumetry on individual multiparametric(mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score. METHODS: Forty-one men with prostate cancer treated with prostatectomy (cohort 1) or radical radiotherapy (cohort 2) who had pre-treatment mp (T2-W, DW-, DCE-) MRI were studied retrospectively. Dominant intraprostatic lesions (DIPLs) were manually delineated on each sequence and volumes compared between observers (n=40 analysable) and with radical prostatectomy (n=20)...
January 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28047490/su-f-j-90-effects-of-optimization-cost-function-on-ventilation-in-sbrt-of-nsclc
#11
I Mihaylov, K Latifi, M De Ornelas-Couto, E Moros, G Zhang
PURPOSE: To explore the effects of dose-volume (Dvh) and dose-mass (Dmh) inverse optimization approaches on the lung ventilation for SBRT in NSCLC. METHODS: Six cases were studied. For each case ventilation was computed on voxel-by-voxel basis, derived from the time-resolved (4D) CT scans. Ventilation is defined as voxel volume change between full inspiration and full expiration, divided by voxel volume. The ventilation volume was mapped to full expiration phase...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047221/we-ab-209-08-novel-beam-specific-adaptive-margins-for-reducing-organ-at-risk-doses
#12
H Tsang, C P Kamerling, P Ziegenhein, S Nill, U Oelfke
PURPOSE: Current practice of using 3D margins in radiotherapy with high-energy photon beams provides larger-than-required target coverage. According to the photon depth-dose curve, target displacements in beam direction result in minute changes in dose delivered. We exploit this behavior by generating margins on a per-beam basis which simultaneously account for the relative distance of the target and adjacent organs-at-risk (OARs). METHODS: For each beam, we consider only geometrical uncertainties of the target location perpendicular to beam direction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033260/transabdominal-preperitoneal-laparoscopic-approach-for-incarcerated-inguinal-hernia-repair-a-report-of-73-cases
#13
Shuo Yang, Guangyong Zhang, Cuihong Jin, Jinxin Cao, Yilin Zhu, Yingmo Shen, Minggang Wang
To investigate the efficacy, key technical points, and complication management of the transabdominal preperitoneal (TAPP) approach for incarcerated inguinal hernia repair. Seventy-three patients with incarcerated inguinal hernias underwent TAPP surgery in our department between Jan 2010 and Dec 2015. A retrospective review was performed by analyzing the perioperative data from these patients. The operation was successfully completed in all 73 patients. Operation time was 54.0 ± 18.8 minutes (range, 35-100 minutes)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28002091/vector-analysis-of-1-year-astigmatic-outcomes-from-a-randomized-fellow-eye-comparison-of-photorefractive-keratectomy-using-2-excimer-laser-platforms
#14
Brian C Toy, Edward E Manche
OBJECTIVE: To compare the astigmatic outcomes of photorefractive keratectomy (PRK) with a wavefront-guided (WFG) and a wavefront-optimized (WFO) excimer laser performed on two different platforms. METHODS: Setting: institutional. DESIGN: Prospective, randomized, fellow eye comparison clinical trial. PARTICIPANTS: A total of 142 eyes of 71 patients with myopia of 12 diopters (D) or less and astigmatism of 3D or less were enrolled at the Byers Eye Institute at Stanford between April 2009 and March 2011...
December 19, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27990416/coordinating-care-for-falls-via-emergency-responders-a-feasibility-study-of-a-brief-at-scene-intervention
#15
REVIEW
Elizabeth A Phelan, Julia Herbert, Carol Fahrenbruch, Benjamin A Stubbs, Hendrika Meischke
Falls account for a substantial portion of 9-1-1 calls, but few studies have examined the potential for an emergency medical system role in fall prevention. We tested the feasibility and effectiveness of an emergency medical technician (EMT)-delivered, at-scene intervention to link elders calling 9-1-1 for a fall with a multifactorial fall prevention program in their community. The intervention was conducted in a single fire department in King County, Washington and consisted of a brief public health message about the preventability of falls and written fall prevention program information left at scene...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27990008/anemia-treatment-by-erythropoiesis-stimulating-agents-during-the-6-months-before-initiation-of-hemodialysis-comparison-between-darbepoetin-alfa-and-continuous-erythropoietin-receptor-activator
#16
Tadashi Yoshida, Matsuhiko Hayashi
Anemia in chronic kidney disease (CKD) is a risk factor for cardiovascular diseases and is treated by long-acting erythropoiesis-stimulating agents (ESA). Although results of previous studies showed that the hemoglobin level could not be maintained at initiation of dialysis in CKD patients treated with recombinant human erythropoietin, it remains undetermined if long-acting ESA are effective to prevent the progression of anemia at initiation of dialysis. In the present study, hemoglobin levels in 40 CKD patients treated with darbepoetin alfa (DA) and 15 CKD patients treated with a continuous erythropoietin receptor activator (CERA) were retrospectively compared during the 6 months period prior to initiation of dialysis...
December 19, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27987571/-active-participation-in-research-and-teaching-during-post-graduate-gp-training-perspectives-of-future-general-practitioners
#17
Hannah Haumann, Elisabeth Flum, Stefanie Joos
BACKGROUND: Academic institutions of general practice at German medical faculties have grown during the past years. This leads to an increase in the need of qualified young researchers and teachers in general practice (GP). Little is known about the interest in research and teaching skills and their training among general practice trainees and young GPs. RESEARCH QUESTION: This cross-sectional survey among GP trainees and young GPs examined 1. if there is an interest in the training in research and teaching skills during post-graduate GP training, 2...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27966894/microrheological-coagulation-assay-exploiting-micromechanical-resonators
#18
Francesco Padovani, James Duffy, Martin Hegner
Rheological measurements in biological liquids yield insights into homeostasis and provide information on important molecular processes that affect fluidity. We present a fully automated cantilever-based method for highly precise and sensitive measurements of microliter sample volumes of human blood plasma coagulation (0.009 cP for viscosity range 0.5-3 cP and 0.0012 g/cm(3) for density range 0.9-1.1 g/cm(3)). Microcantilever arrays are driven by a piezoelectric element, and resonance frequencies and quality factors of sensors that change over time are evaluated...
December 14, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27940957/magnetic-resonance-augmented-cardiopulmonary-exercise-testing-comprehensively-assessing-exercise-intolerance-in-children-with-cardiovascular-disease
#19
Nathaniel J Barber, Emmanuel O Ako, Gregorz T Kowalik, Mun H Cheang, Bejal Pandya, Jennifer A Steeden, Shahin Moledina, Vivek Muthurangu
BACKGROUND: Conventional cardiopulmonary exercise testing can objectively measure exercise intolerance but cannot provide comprehensive evaluation of physiology. This requires additional assessment of cardiac output and arteriovenous oxygen content difference. We developed magnetic resonance (MR)-augmented cardiopulmonary exercise testing to achieve this goal and assessed children with right heart disease. METHODS AND RESULTS: Healthy controls (n=10) and children with pulmonary arterial hypertension (PAH; n=10) and repaired tetralogy of Fallot (n=10) underwent MR-augmented cardiopulmonary exercise testing...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27940715/transcutaneous-bilirubinometry-in-jaundiced-neonates-a-randomized-controlled-trial
#20
Bernice van den Esker-Jonker, Lieve den Boer, Rianne M C Pepping, Jolita Bekhof
BACKGROUND: For evaluation of jaundiced neonates, serum bilirubin (SB) or transcutaneous bilirubinometry (TcB) is used. Few data are available on the quantitative reduction of blood sampling by using TcB. METHODS: We conducted a randomized controlled trial in hospitalized jaundiced neonates ≥32 weeks' gestational age. In the intervention group, TcB was used and in the control group the decision to obtain a blood sample for SB was based on visual and clinical assessment...
December 2016: Pediatrics
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