Rachel L Padget, Michael J Zeitz, Grace A Blair, Xiaobo Wu, Michael D North, Mira T Tanenbaum, Kari E Stanley, Chelsea M Phillips, D Ryan King, Samy Lamouille, Robert G Gourdie, Gregory S Hoeker, Sharon A Swanger, Steven Poelzing, James W Smyth
BACKGROUND: Viral cardiac infection represents a significant clinical challenge encompassing several etiological agents, disease stages, complex presentation, and a resulting lack of mechanistic understanding. Myocarditis is a major cause of sudden cardiac death in young adults, where current knowledge in the field is dominated by later disease phases and pathological immune responses. However, little is known regarding how infection can acutely induce an arrhythmogenic substrate before significant immune responses...
February 28, 2024: Circulation Research