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https://www.readbyqxmd.com/read/29753823/analysis-of-differentially-changed-gene-expression-in-ea-hy926-human-endothelial-cell-after-exposure-of-fine-particulate-matter-on-the-basis-of-microarray-profile
#1
Yan Wang, Lilin Xiong, Tianshu Wu, Ting Zhang, Lu Kong, Yuying Xue, Meng Tang
Epidemiological studies have illustrated that PM2.5 is closely related to cardiovascular disease (CVD), but underlying toxicological mechanisms are not yet clear. The main purpose of this study is to disclose the potential biological mechanisms responsible for PM2.5-dependent adverse cardiovascular outcomes through the appliance of genome-wide transcription microarray. From results, compared with the control group, there are 97 genes significantly altered in 2.5 μg/cm2 PM2.5 treated group and 440 differentially expressed genes in 10 μg/cm2 group...
May 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29751293/the-potential-atheroprotective-role-of-plant-mir156a-as-a-repressor-of-monocyte-recruitment-on-inflamed-human-endothelial-cells
#2
Dongxia Hou, Fangfang He, Lina Ma, Minghui Cao, Zhen Zhou, Zhe Wei, Yunxing Xue, Xiaolin Sang, Hoshun Chong, Congcong Tian, Shasha Zheng, Jing Li, Ke Zen, Xi Chen, Zhi Hong, Chen-Yu Zhang, Xiaohong Jiang
MicroRNAs have become the spotlight of the biological community for more than a decade, but we are only now beginning to understand their functions. The detection of stably expressed endogenous microRNAs in human blood suggests that these circulating miRNAs can mediate intercellular communication. Our previous study reported the surprising finding that exogenous rice MIR168a could regulate liver low-density lipoprotein receptor adapter protein 1 (LDLRAP1) gene expression in mice. Here, we show that plant MIR156a, which is abundantly expressed in dietary green veggies, also stably presents in healthy human serum...
April 8, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29749551/angiotensin-ii-inhibits-the-protein-expression-of-zo%C3%A2-1-in-vascular-endothelial-cells-by-downregulating-ve%C3%A2-cadherin
#3
Longbin Liu, Liping Meng, Peng Zhang, Hui Lin, Jufang Chi, Fang Peng, Hangyuan Guo
Angiotensin II (Ang II) is reported to be involved in the development of various cardiovascular diseases by disrupting microvessel permeability, however, the underlying mechanism remains to be elucidated. The present study aimed to investigate the mechanism by which Ang II disrupts microvascular permeability. Rat endothelial cells were subjected to primary culture and identification. Cells in passages 4‑7 were then used for the following experiments. The cells were divided into control, Ang II, and Ang II + valsartan groups, and reverse transcription‑quantitative polymerase chain reaction and western blot analyses were perform to evaluate the expression of zonula occludens‑1 (ZO‑1) and vascular endothelial (VE)‑cadherin in the cells...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29734990/exosomal-cargo-properties-endothelial-function-and-treatment-of-obesity-hypoventilation-syndrome-a-proof-of-concept-study
#4
Rakesh Bhattacharjee, Abdelnaby Khalyfa, Ahamed A Khalyfa, Babak Mokhlesi, Leila Kheirandish-Gozal, Isaac Almendros, Eduard Peris, Atul Malhotra, David Gozal
STUDY OBJECTIVES: Longitudinal studies support the usage of positive airway pressure (PAP) therapy in treating obstructive sleep apnea (OSA) to improve cardiovascular disease. However, the anticipated benefit is not ubiquitous. In this study, we elucidate whether PAP therapy leads to immediate improvements on endothelial function, a subclinical marker of cardiovascular status, by examining the effect of circulating exosomes, isolated from patients before and after PAP therapy, on naive endothelial cells...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29695249/aortic-flow-patterns-and-wall-shear-stress-maps-by-4d-flow-cardiovascular-magnetic-resonance-in-the-assessment-of-aortic-dilatation-in-bicuspid-aortic-valve-disease
#5
José Fernando Rodríguez-Palomares, Lydia Dux-Santoy, Andrea Guala, Raquel Kale, Giuliana Maldonado, Gisela Teixidó-Turà, Laura Galian, Marina Huguet, Filipa Valente, Laura Gutiérrez, Teresa González-Alujas, Kevin M Johnson, Oliver Wieben, David García-Dorado, Arturo Evangelista
BACKGROUND: In patients with bicuspid valve (BAV), ascending aorta (AAo) dilatation may be caused by altered flow patterns and wall shear stress (WSS). These differences may explain different aortic dilatation morphotypes. Using 4D-flow cardiovascular magnetic resonance (CMR), we aimed to analyze differences in flow patterns and regional axial and circumferential WSS maps between BAV phenotypes and their correlation with ascending aorta dilatation morphotype. METHODS: One hundred and one BAV patients (aortic diameter ≤ 45 mm, no severe valvular disease) and 20 healthy subjects were studied by 4D-flow CMR...
April 26, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29686973/microrna-4516-contributes-to-different-functions-of-epithelial-permeability-barrier-by-targeting-poliovirus-receptor-related-protein-1-in-enterovirus-71-and-coxsackievirus-a16-infections
#6
Yajie Hu, Jie Song, Longding Liu, Ying Zhang, Lichun Wang, Qihan Li
Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) remain the predominant etiological agents of hand, foot, and mouth disease (HFMD). The clinical manifestations caused by the two viruses are obviously different. CV-A16 usually triggers a repeated infection, and airway epithelial integrity is often the potential causative factor of respiratory repeated infections. Our previous studies have demonstrated that there were some differentially expressed miRNAs involved in the regulation of adhesion function of epithelial barrier in EV-A71 and CV-A16 infections...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29615110/gut-dependent-microbial-translocation-induces-inflammation-and-cardiovascular-events-after-st-elevation-myocardial-infarction
#7
Xin Zhou, Jing Li, Junli Guo, Bin Geng, Wenjie Ji, Qian Zhao, Jinlong Li, Xinlin Liu, Junxiang Liu, Zhaozeng Guo, Wei Cai, Yongqiang Ma, Dong Ren, Jun Miao, Shaobo Chen, Zhuoli Zhang, Junru Chen, Jiuchang Zhong, Wenbin Liu, Minghui Zou, Yuming Li, Jun Cai
BACKGROUND: Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during the past decades. Experimental observations have involved intestinal microbiota in the susceptibility to MI in mice; however, in humans, identifying whether translocation of gut bacteria to systemic circulation contributes to cardiovascular events post-MI remains a major challenge. RESULTS: Here, we carried out a metagenomic analysis to characterize the systemic bacteria in a cohort of 49 healthy control individuals, 50 stable coronary heart disease (CHD) subjects, and 100 ST-segment elevation myocardial infarction (STEMI) patients...
April 3, 2018: Microbiome
https://www.readbyqxmd.com/read/29574800/high-salt-induced-excess-reactive-oxygen-species-production-resulted-in-heart-tube-malformation-during-gastrulation
#8
Lin-Rui Gao, Guang Wang, Jing Zhang, Shuai Li, Manli Chuai, Yongping Bao, Berthold Hocher, Xuesong Yang
An association has been proved between high salt consumption and cardiovascular mortality. In vertebrates, the heart is the first functional organ to be formed. However, it is not clear whether high-salt exposure has an adverse impact on cardiogenesis. Here we report high-salt exposure inhibited basement membrane breakdown by affecting RhoA, thus disturbing the expression of Slug/E-cadherin/N-cadherin/Laminin and interfering with mesoderm formation during the epithelial-mesenchymal transition(EMT). Furthermore, the DiI+ cell migration trajectory in vivo and scratch wound assays in vitro indicated that high-salt exposure restricted cell migration of cardiac progenitors, which was caused by the weaker cytoskeleton structure and unaltered corresponding adhesion junctions at HH7...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29549620/efficient-computational-modeling-of-human-ventricular-activation-and-its-electrocardiographic-representation-a-sensitivity-study
#9
Jonathan P Cranford, Thomas J O'Hara, Christopher T Villongco, Omar M Hafez, Robert C Blake, Joseph Loscalzo, Jean-Luc Fattebert, David F Richards, Xiaohua Zhang, James N Glosli, Andrew D McCulloch, David E Krummen, Felice C Lightstone, Sergio E Wong
Patient-specific models of the ventricular myocardium, combined with the computational power to run rapid simulations, are approaching the level where they could be used for personalized cardiovascular medicine. A major remaining challenge is determining model parameters from available patient data, especially for models of the Purkinje-myocardial junctions (PMJs): the sites of initial ventricular electrical activation. There are no non-invasive methods for localizing PMJs in patients, and the relationship between the standard clinical ECG and PMJ model parameters is underexplored...
March 16, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29545218/management-issues-in-a-case-of-congenital-cv-junction-anomaly-with-aberrant-retropharyngeal-midline-course-of-bilateral-cervical-icas-at-c1-c2
#10
Narayanam Anantha Sai Kiran, Veldurti Ananta Kiran Kumar, Laxminadh Sivaraju, Valluri Anil Kumar, Chintakunta Rajesh Reddy, Amit Agrawal
BACKGROUND: Aberrant medial retropharyngeal prevertebral course of internal carotid arteries (ICAs) is extremely uncommon. In oropharyngeal surgeries like trans oral odontoidectomy (TOO) this unrecognized aberrant retropharyngeal course of ICAs can result in devastating complications secondary to inadvertent injury of ICAs. Authors describe this aberrant course of ICAs in a patient with craniovertebral junction (CVJ) anomaly with dysmorphic C1 lateral mass on one side and discuss in detail various management issues in this complex case...
March 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29543751/role-of-non-myocyte-gap-junctions-and-connexin-hemichannels-in-cardiovascular-health-and-disease-novel-therapeutic-targets
#11
REVIEW
Robert D Johnson, Patrizia Camelliti
The heart is a complex organ composed of multiple cell types, including cardiomyocytes and different non-myocyte populations, all working closely together to determine the hearts properties and maintain normal cardiac function. Connexins are abundantly expressed proteins that form plasma membrane hemichannels and gap junctions between cells. Gap junctions are intracellular channels that allow for communication between cells, and in the heart they play a crucial role in cardiac conduction by coupling adjacent cardiomyocytes...
March 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29523750/altered-microbiome-in-chronic-kidney-disease-systemic-effects-of-gut-derived-uremic-toxins
#12
REVIEW
Wei Ling Lau, Javad Savoj, Michael B Nakata, Nosratola D Vaziri
In chronic kidney disease (CKD), influx of urea and other retained toxins exerts a change in the gut microbiome. There is decreased number of beneficial bacteria that produce short-chain fatty acids, an essential nutrient for the colonic epithelium, concurrent with an increase in bacteria that produce uremic toxins such as indoxyl sulphate, p -cresyl sulphate, and trimethylamine-N-oxide (TMAO). Due to intestinal wall inflammation and degradation of intercellular tight junctions, gut-derived uremic toxins translocate into the bloodstream and exert systemic effects...
March 15, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29521313/identification-of-differentially-expressed-circular-rnas-during-tgf-%C3%A3-1-induced-endothelial-to-mesenchymal-transition-in-rat-coronary-artery-endothelial-cells
#13
Xingfu Huang, Yanjia Chen, Junhui Xiao, Zheng Huang, Liwei He, Dingli Xu, Jian Peng
OBJECTIVE: Although differentially expressed circRNAs have been proposed to be closely associated with epithelial-mesenchymal transition (EMT), the roles of circRNAs remain unclear in endothelial-to-mesenchymal transition (EndMT), which is a subcategory of EMT. Herein, we characterized the expression and potential function of circRNAs during TGF-ß1-induced EndMT in rat coronary artery endothelial cells (CAEC). METHODS: High-throughput RNA sequencing was performed for unbiasedly profiling the expression of circRNAs...
March 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29513135/mechanical-signaling-through-the-discoidin-domain-receptor-1-plays-a-central-role-in-tissue-fibrosis
#14
Nuno M Coelho, Christopher A McCulloch
The preservation of tissue and organ architecture and function depends on tightly regulated interactions of cells with the extracellular matrix (ECM). These interactions are maintained in a dynamic equilibrium that balances intracellular, myosin-generated tension with extracellular resistance conferred by the mechanical properties of the extracellular matrix. Disturbances of this equilibrium can lead to the development of fibrotic lesions that are associated with a wide repertoire of high prevalence diseases including obstructive cardiovascular diseases, muscular dystrophy and cancer...
March 26, 2018: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29507058/imbalance-of-gut-microbiome-and-intestinal-epithelial-barrier-dysfunction-in-patients-with-high-blood-pressure
#15
Seungbum Kim, Ruby Goel, Ashok Kumar, Yanfei Qi, Gil Lobaton, Koji Hosaka, Mohammed Mohammed, Eileen M Handberg, Elaine M Richards, Carl J Pepine, Mohan K Raizada
Recent evidence indicates a link between gut pathology and microbiome with hypertension (HTN) in animal models. However, whether this association exists in humans is unknown. Thus, our objectives in the present study were to test the hypotheses that high blood pressure (BP) patients have distinct gut microbiomes and that gut-epithelial barrier function markers and microbiome composition could predict systolic BP (SBP). Fecal samples, analyzed by shotgun metagenomics, displayed taxonomic and functional changes, including altered butyrate production between patients with high BP and reference subjects...
March 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29502388/horseshoe-kidney-and-uretero-pelvic-junction-obstruction-in-a-pediatric-patient-laparoscopic-vascular-hitch-a-valid-alternative-to-dismembered-pyeloplasty
#16
Cosimo Bleve, Valeria Bucci, Maria Luisa Conighi, Francesco Battaglino, Lorenzo Costa, Lorella Fasoli, Elisa Zolpi, Salvatore Fabio Chiarenza
Horseshoe kidney (HSK) is a congenital defect of the urinary tract that occurs in 0.25% of the general population. Laparoscopic Vascular Hitch (LVH) according to Hellstrom-Chapman represent an alternative approach in treatment of extrinsic hydronephrosis by crossing vessels (CV) in pediatric age. In our Department from 2006 to 2016, 36 children with extrinsic-Uretero-Pelvic-Junction (UPJ)-Obstruction (UPJO) underwent laparoscopic vessels transposition. Over the last 4years, we have treated three patients with extrinsic hydronephrosis in HSK; two males and one female respectively of 6, 7 and 8years...
December 13, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/29467337/nitric-oxide-sensitive-guanylyl-cyclase-stimulation-improves-experimental-heart-failure-with-preserved-ejection-fraction
#17
Nicola Wilck, Lajos Markó, András Balogh, Kristin Kräker, Florian Herse, Hendrik Bartolomaeus, István A Szijártó, Maik Gollasch, Nadine Reichhart, Olaf Strauss, Arnd Heuser, Damian Brockschnieder, Axel Kretschmer, Ralf Lesche, Florian Sohler, Johannes-Peter Stasch, Peter Sandner, Friedrich C Luft, Dominik N Müller, Ralf Dechend, Nadine Haase
Heart failure with preserved ejection fraction (HFpEF) can arise from cardiac and vascular remodeling processes following long-lasting hypertension. Efficacy of common HF therapeutics is unsatisfactory in HFpEF. Evidence suggests that stimulators of the nitric oxide-sensitive soluble guanylyl cyclase (NOsGC) could be of use here. We aimed to characterize the complex cardiovascular effects of NOsGC stimulation using NO-independent stimulator BAY 41-8543 in a double-transgenic rat (dTGR) model of HFpEF. We show a drastically improved survival rate of treated dTGR...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29395647/expression-of-connexin43-in-cerebral-arteries-of-patients-with-moyamoya-disease
#18
Jiaqi Liao, Tao Hong, Jinxian Xu, Erming Zeng, Bin Tang, Wentao Lai
BACKGROUND AND PURPOSE: Moyamoya disease has a high incidence of cerebral vascular accident in children and adolescents, which can endanger the physical and mental health of children and adults seriously. However, the etiology and the pathogenesis of moyamoya disease remain unclear. Connexin43 (Cx43) is a predominant intercellular gap junction protein that plays an important role in the normal function of arteries and the development of several cardiovascular diseases. We aimed to preliminarily investigate pathological changes and the expression of Cx43 in cerebral arteries of patients with moyamoya disease...
April 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29385021/pde4-mediated-camp-signalling
#19
REVIEW
Bracy A Fertig, George S Baillie
cAMP is the archetypal and ubiquitous second messenger utilised for the fine control of many cardiovascular cell signalling systems. The ability of cAMP to elicit cell surface receptor-specific responses relies on its compartmentalisation by cAMP hydrolysing enzymes known as phosphodiesterases. One family of these enzymes, PDE4, is particularly important in the cardiovascular system, where it has been extensively studied and shown to orchestrate complex, localised signalling that underpins many crucial functions of the heart...
January 31, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29314148/3d-reconstruction-of-the-porcine-and-equine-pulmonary-veins-supplemented-with-the-identification-of-telocytes-in-the-horse
#20
T Vandecasteele, W Van Den Broeck, H Tay, L Couck, G van Loon, P Cornillie
The myocardial sleeve of the porcine and equine pulmonary veins were histologically investigated and reconstructed three dimensionally. Moreover, the localization of neuron cell bodies at the veno-atrial junction and alongside the myocardial sleeve was light microscopically visualized to depict the organization of nerve, myocardial and fat tissue. Finally, the presence of telocytes inside the equine pulmonary veins was demonstrated by use of transmission electron microscopy. These structures are thought to play a role in the induction of atrial fibrillation, which is frequently seen in horses, while pigs are often used as a cardiovascular model in this context...
April 2018: Anatomia, Histologia, Embryologia
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