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https://www.readbyqxmd.com/read/29988898/retroperitoneal-laparoscopic-non-dismembered-pyeloplasty-for-uretero-pelvic-junction-obstruction-due-to-crossing-vessels-a-matched-paired-analysis-and-review-of-literature
#1
Jens Rassweiler, Jan Klein, Ali Serdar Goezen
Objective: To compare laparoscopic Anderson-Hynes pyeloplasty (LAHP) and retroperitoneal laparoscopic YV-pyeloplasty (LRYVP) in ureteropelvic junction obstruction (UPJ) in presence of a crossing vessels (CV). Methods: Our database showed 380 UPJO-cases,who underwent laparoscopic retroperitoneal surgery during the last 2 decades including 206 non-dismembered LRYVP, 157 dismembered pyeloplasties LAHP, and 17 cases of laparoscopic ureterolysis. Among them 198 cases were suitable for a matched-pair (2:1) analysis comparing laparoscopic retroperitoneal non-dismembered LRYVP (Group 1, n  = 131) and dismembered LAHP (Group 2, n  = 67) in presence of a crossing vessel...
July 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29980408/perianesthetic-implications-and-considerations-for-myasthenia-gravis
#2
Virginia C Muckler, Jennifer M O'Brien, Stephen E Matson, Andi N Rice
Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease in which antibodies against the post-nicotinic acetylcholine receptor at the neuromuscular junction develop. Although the exact cause of MG remains unknown, the thymus is a common factor in many cases. Patients with underlying junctional disease, such as MG, have greater anesthesia-related risks because of their known predisposition toward prolonged muscle weakness. Medications given in the perioperative period, such as anesthetic agents, antibiotics, cardiovascular drugs, and corticosteroids, affect neuromuscular transmission that contributes to muscle weakness...
July 3, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29976618/adamts13-deficiency-shortens-the-lifespan-of-mice-with-experimental-diabetes
#3
Paola Cassis, Domenico Cerullo, Cristina Zanchi, Daniela Corna, Vincenzo Lionetti, Fabrizio Giordano, Rubina Novelli, Sara Conti, Valentina Casieri, Marco Matteucci, Monica Locatelli, Giulia Taraboletti, Sebastian Villa, Sara Gastoldi, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja
In patients with diabetes, impaired activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13), the plasma metalloprotease that cleaves highly thrombogenic VWF multimers is a major risk factor of cardiovascular events. Here, using Adamts13 -/- mice made diabetic by streptozotocin, we investigated the impact of the lack of ADAMTS13 on the development of diabetes-associated end-organ complications. Adamts13 -/- mice experienced shortened lifespan compared with their wild-type diabetic littermates...
July 5, 2018: Diabetes
https://www.readbyqxmd.com/read/29971234/the-transcriptomic-analysis-of-circulating-immune-cells-in-a-celiac-family-unveils-further-insights-into-disease-pathogenesis
#4
Rachele Ciccocioppo, Simona Panelli, Maria C Conti Bellocchi, Giuseppina C Cangemi, Luca Frulloni, Enrica Capelli, Gino R Corazza
Celiac disease (CD), the most common chronic enteropathy worldwide, is triggered and sustained by a dysregulated immune response to dietary gluten in genetically susceptible individuals. Up to date either the role of environmental factors and the pathways leading to mucosal damage have been only partially unraveled. Therefore, we seized the unique opportunity to study a naturally-occurring experimental model of a family composed of both parents suffering from CD (one on a gluten-free diet) and two non-celiac daughters...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29968241/-diagnosis-and-treatment-of-iatrogenic-colonoscopic-perforation
#5
Heng Wang, Ang Li, Xiaohui Shi, Xiaodong Xu, Hantao Wang, Hao Wang, Enda Yu
OBJECTIVE: To summarize the diagnosis and treatment of iatrogenic colonoscopic perforation (ICP). METHODS: Clinical data, treatment course and outcome of 17 patients who developed ICP following colonoscopic examination or operation at Department of Colorectal Surgery, Changhai Hospital from January 2000 to December 2013 were retrospectively analyzed. RESULTS: During above 13 years, a total of 127 106 patients underwent colonoscopic examination or operation, of whom 17 cases (0...
June 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29941006/water-ethanol-extract-of-cucumis-sativus-l-fruit-attenuates-lipopolysaccharide-induced-inflammatory-response-in-endothelial-cells
#6
Chiara Bernardini, Augusta Zannoni, Martina Bertocchi, Irvin Tubon, Mercedes Fernandez, Monica Forni
BACKGROUND: It is widely accepted the key role of endothelium in the onset of many chronic and acute vascular and cardiovascular diseases. In the last decade, traditional compounds utilized in "folk medicine" were considered with increasing interest to discover new bioactive molecules potentially effective in a wide range of diseases including cardiovascular ones. Since ancient times different parts of the Cucumis sativus L. plant were utilized in Ayurvedic medicine, among these, fruits were traditionally used to alleviate skin problem such as sunburn irritation and inflammation...
June 25, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29894844/atorvastatin-enhances-endothelial-adherens-junctions-through-promoting-ve-ptp-gene-transcription-and-reducing-ve-cadherin-y731-phosphorylation
#7
Zihe Huo, Ying Kong, Mei Meng, Zhifei Cao, Quansheng Zhou
Vascular endothelial protein tyrosine phosphatase (VE-PTP) is essential for endothelial cells (ECs) adherens junction and vascular homeostasis; however, the regulatory mechanism of VE-PTP transcription is unknown, and a drug able to promote VE-PTP expression in ECs has not yet been reported in the literature. In this study, we used human ECs as a model to explore small molecule compounds able to promote VE-PTP expression, and found that atorvastatin, a HMG-CoA reductase inhibitor widely used in the clinic to treat hypercholesterolemia-related cardiovascular diseases, strongly promoted VE-PTP transcription in ECs through activating the VE-PTP promoter and upregulating the expression of the transcription factor, specificity protein 1 (SP1)...
June 9, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29844145/modeling-superimposed-preeclampsia-using-ang-ii-angiotensin-ii-infusion-in-pregnant-stroke-prone-spontaneously-hypertensive-rats
#8
Hannah L Morgan, Elaine Butler, Shona Ritchie, Florian Herse, Ralf Dechend, Elisabeth Beattie, Martin W McBride, Delyth Graham
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and developing treatment options are crucial. The pregnant stroke-prone spontaneously hypertensive rat has impaired uteroplacental blood flow and abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats to mimic the increased cardiovascular stress associated with superimposed preeclampsia and examine the impact on the maternal cardiovascular system and fetal development...
July 2018: Hypertension
https://www.readbyqxmd.com/read/29795549/variability-in-pulmonary-vein-electrophysiology-and-fibrosis-determines-arrhythmia-susceptibility-and-dynamics
#9
Caroline H Roney, Jason D Bayer, Hubert Cochet, Marianna Meo, Rémi Dubois, Pierre Jaïs, Edward J Vigmond
Success rates for catheter ablation of persistent atrial fibrillation patients are currently low; however, there is a subset of patients for whom electrical isolation of the pulmonary veins alone is a successful treatment strategy. It is difficult to identify these patients because there are a multitude of factors affecting arrhythmia susceptibility and maintenance, and the individual contributions of these factors are difficult to determine clinically. We hypothesised that the combination of pulmonary vein (PV) electrophysiology and atrial body fibrosis determine driver location and effectiveness of pulmonary vein isolation (PVI)...
May 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29778719/effect-of-heptanol-and-ethanol-on-excitation-wave-propagation-in-a-neonatal-rat-ventricular-myocyte-monolayer
#10
A D Podgurskaya, V A Tsvelaya, S R Frolova, I Y Kalita, N N Kudryashova, K I Agladze
In this work, the action of heptanol and ethanol was investigated in a two-dimensional (2D) model of cardiac tissue: the neonatal rat ventricular myocyte monolayer. Heptanol is known in electrophysiology as a gap junction uncoupler but may also inhibit voltage-gated ionic channels. Ethanol is often associated with the occurrence of arrhythmias. These substances influence sodium, calcium, and potassium channels, but the complete mechanism of action of heptanol and ethanol remains unknown. The optical mapping method was used to measure conduction velocities (CVs) in concentrations of 0...
September 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29753823/analysis-of-differentially-changed-gene-expression-in-ea-hy926-human-endothelial-cell-after-exposure-of-fine-particulate-matter-on-the-basis-of-microarray-profile
#11
Yan Wang, Lilin Xiong, Tianshu Wu, Ting Zhang, Lu Kong, Yuying Xue, Meng Tang
Epidemiological studies have illustrated that PM2.5 is closely related to cardiovascular disease (CVD), but underlying toxicological mechanisms are not yet clear. The main purpose of this study is to disclose the potential biological mechanisms responsible for PM2.5-dependent adverse cardiovascular outcomes through the appliance of genome-wide transcription microarray. From results, compared with the control group, there are 97 genes significantly altered in 2.5 μg/cm2 PM2.5 treated group and 440 differentially expressed genes in 10 μg/cm2 group...
September 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29751293/the-potential-atheroprotective-role-of-plant-mir156a-as-a-repressor-of-monocyte-recruitment-on-inflamed-human-endothelial-cells
#12
Dongxia Hou, Fangfang He, Lina Ma, Minghui Cao, Zhen Zhou, Zhe Wei, Yunxing Xue, Xiaolin Sang, Hoshun Chong, Congcong Tian, Shasha Zheng, Jing Li, Ke Zen, Xi Chen, Zhi Hong, Chen-Yu Zhang, Xiaohong Jiang
MicroRNAs have become the spotlight of the biological community for more than a decade, but we are only now beginning to understand their functions. The detection of stably expressed endogenous microRNAs in human blood suggests that these circulating miRNAs can mediate intercellular communication. Our previous study reported the surprising finding that exogenous rice MIR168a could regulate liver low-density lipoprotein receptor adapter protein 1 (LDLRAP1) gene expression in mice. Here, we show that plant MIR156a, which is abundantly expressed in dietary green veggies, also stably presents in healthy human serum...
July 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29749551/angiotensin-ii-inhibits-the-protein-expression-of-zo%C3%A2-1-in-vascular-endothelial-cells-by-downregulating-ve%C3%A2-cadherin
#13
Longbin Liu, Liping Meng, Peng Zhang, Hui Lin, Jufang Chi, Fang Peng, Hangyuan Guo
Angiotensin II (Ang II) is reported to be involved in the development of various cardiovascular diseases by disrupting microvessel permeability, however, the underlying mechanism remains to be elucidated. The present study aimed to investigate the mechanism by which Ang II disrupts microvascular permeability. Rat endothelial cells were subjected to primary culture and identification. Cells in passages 4‑7 were then used for the following experiments. The cells were divided into control, Ang II, and Ang II + valsartan groups, and reverse transcription‑quantitative polymerase chain reaction and western blot analyses were perform to evaluate the expression of zonula occludens‑1 (ZO‑1) and vascular endothelial (VE)‑cadherin in the cells...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29734990/exosomal-cargo-properties-endothelial-function-and-treatment-of-obesity-hypoventilation-syndrome-a-proof-of-concept-study
#14
Rakesh Bhattacharjee, Abdelnaby Khalyfa, Ahamed A Khalyfa, Babak Mokhlesi, Leila Kheirandish-Gozal, Isaac Almendros, Eduard Peris, Atul Malhotra, David Gozal
STUDY OBJECTIVES: Longitudinal studies support the usage of positive airway pressure (PAP) therapy in treating obstructive sleep apnea (OSA) to improve cardiovascular disease. However, the anticipated benefit is not ubiquitous. In this study, we elucidate whether PAP therapy leads to immediate improvements on endothelial function, a subclinical marker of cardiovascular status, by examining the effect of circulating exosomes, isolated from patients before and after PAP therapy, on naive endothelial cells...
May 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29695249/aortic-flow-patterns-and-wall-shear-stress-maps-by-4d-flow-cardiovascular-magnetic-resonance-in-the-assessment-of-aortic-dilatation-in-bicuspid-aortic-valve-disease
#15
José Fernando Rodríguez-Palomares, Lydia Dux-Santoy, Andrea Guala, Raquel Kale, Giuliana Maldonado, Gisela Teixidó-Turà, Laura Galian, Marina Huguet, Filipa Valente, Laura Gutiérrez, Teresa González-Alujas, Kevin M Johnson, Oliver Wieben, David García-Dorado, Arturo Evangelista
BACKGROUND: In patients with bicuspid valve (BAV), ascending aorta (AAo) dilatation may be caused by altered flow patterns and wall shear stress (WSS). These differences may explain different aortic dilatation morphotypes. Using 4D-flow cardiovascular magnetic resonance (CMR), we aimed to analyze differences in flow patterns and regional axial and circumferential WSS maps between BAV phenotypes and their correlation with ascending aorta dilatation morphotype. METHODS: One hundred and one BAV patients (aortic diameter ≤ 45 mm, no severe valvular disease) and 20 healthy subjects were studied by 4D-flow CMR...
April 26, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29686973/microrna-4516-contributes-to-different-functions-of-epithelial-permeability-barrier-by-targeting-poliovirus-receptor-related-protein-1-in-enterovirus-71-and-coxsackievirus-a16-infections
#16
Yajie Hu, Jie Song, Longding Liu, Ying Zhang, Lichun Wang, Qihan Li
Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) remain the predominant etiological agents of hand, foot, and mouth disease (HFMD). The clinical manifestations caused by the two viruses are obviously different. CV-A16 usually triggers a repeated infection, and airway epithelial integrity is often the potential causative factor of respiratory repeated infections. Our previous studies have demonstrated that there were some differentially expressed miRNAs involved in the regulation of adhesion function of epithelial barrier in EV-A71 and CV-A16 infections...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29615110/gut-dependent-microbial-translocation-induces-inflammation-and-cardiovascular-events-after-st-elevation-myocardial-infarction
#17
Xin Zhou, Jing Li, Junli Guo, Bin Geng, Wenjie Ji, Qian Zhao, Jinlong Li, Xinlin Liu, Junxiang Liu, Zhaozeng Guo, Wei Cai, Yongqiang Ma, Dong Ren, Jun Miao, Shaobo Chen, Zhuoli Zhang, Junru Chen, Jiuchang Zhong, Wenbin Liu, Minghui Zou, Yuming Li, Jun Cai
BACKGROUND: Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during the past decades. Experimental observations have involved intestinal microbiota in the susceptibility to MI in mice; however, in humans, identifying whether translocation of gut bacteria to systemic circulation contributes to cardiovascular events post-MI remains a major challenge. RESULTS: Here, we carried out a metagenomic analysis to characterize the systemic bacteria in a cohort of 49 healthy control individuals, 50 stable coronary heart disease (CHD) subjects, and 100 ST-segment elevation myocardial infarction (STEMI) patients...
April 3, 2018: Microbiome
https://www.readbyqxmd.com/read/29574800/high-salt-induced-excess-reactive-oxygen-species-production-resulted-in-heart-tube-malformation-during-gastrulation
#18
Lin-Rui Gao, Guang Wang, Jing Zhang, Shuai Li, Manli Chuai, Yongping Bao, Berthold Hocher, Xuesong Yang
An association has been proved between high salt consumption and cardiovascular mortality. In vertebrates, the heart is the first functional organ to be formed. However, it is not clear whether high-salt exposure has an adverse impact on cardiogenesis. Here we report high-salt exposure inhibited basement membrane breakdown by affecting RhoA, thus disturbing the expression of Slug/E-cadherin/N-cadherin/Laminin and interfering with mesoderm formation during the epithelial-mesenchymal transition(EMT). Furthermore, the DiI+ cell migration trajectory in vivo and scratch wound assays in vitro indicated that high-salt exposure restricted cell migration of cardiac progenitors, which was caused by the weaker cytoskeleton structure and unaltered corresponding adhesion junctions at HH7...
September 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29549620/efficient-computational-modeling-of-human-ventricular-activation-and-its-electrocardiographic-representation-a-sensitivity-study
#19
Jonathan P Cranford, Thomas J O'Hara, Christopher T Villongco, Omar M Hafez, Robert C Blake, Joseph Loscalzo, Jean-Luc Fattebert, David F Richards, Xiaohua Zhang, James N Glosli, Andrew D McCulloch, David E Krummen, Felice C Lightstone, Sergio E Wong
Patient-specific models of the ventricular myocardium, combined with the computational power to run rapid simulations, are approaching the level where they could be used for personalized cardiovascular medicine. A major remaining challenge is determining model parameters from available patient data, especially for models of the Purkinje-myocardial junctions (PMJs): the sites of initial ventricular electrical activation. There are no non-invasive methods for localizing PMJs in patients, and the relationship between the standard clinical ECG and PMJ model parameters is underexplored...
March 16, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29545218/management-issues-in-a-case-of-congenital-craniovertebral-junction-anomaly-with-aberrant-retropharyngeal-midline-course-of-bilateral-cervical-internal-carotid-arteries-at-c1-c2
#20
Narayanam Anantha Sai Kiran, Veldurti Ananta Kiran Kumar, Laxminadh Sivaraju, Valluri Anil Kumar, Chintakunta Rajesh Reddy, Amit Agrawal
BACKGROUND: Aberrant medial retropharyngeal prevertebral course of the internal carotid arteries (ICAs) is extremely uncommon. In oropharyngeal surgeries, like transoral odontoidectomy (TOO), this unrecognized aberrant retropharyngeal course of ICAs can result in devastating complications secondary to inadvertent injury of ICAs. We describe this aberrant course of ICAs in a patient with a craniovertebral junction (CVJ) anomaly with a dysmorphic C1 lateral mass on one side and discuss in detail various management issues in this complex case...
June 2018: World Neurosurgery
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