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https://www.readbyqxmd.com/read/30152767/surgical-treatment-outcomes-in-metastatic-tumours-located-at-the-craniocervical-junction
#1
Piotr Biega, Grzegorz Guzik, Tomasz Pitera
BACKGROUND: Cancer metastases to the upper section of the cervical spine are found in a low percentage of patients. Their conservative treatment consists in radio- and chemotherapy as well as immobilisation in an orthopaedic collar. Surgery is the treatment of choice in patients with lesions causing spinal instability or compressing neural structures. The aim of this study was to assess the outcomes of surgical treatment conducted in patients with metastases located in the upper section of the cervical spine...
February 27, 2018: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/30138325/neoadjuvant-chemotherapy-versus-neoadjuvant-chemoradiotherapy-for-cancer-of-the-esophagus-or-the-gastroesophageal-junction-a-meta-analysis-based-on-clinical-trials
#2
Xin Zhao, Yiming Ren, Yong Hu, Naiqiang Cui, Ximo Wang, Yunfeng Cui
BACKGROUND: The benefit of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for treating cancer of the esophagus or the gastroesophageal junction remains controversial. In the present study, we conducted a comprehensive meta-analysis to examine the efficacy of these two management strategies. METHODS: The MEDLINE (PubMed), SinoMed, Embase, and Cochrane Library databases were searched for eligible studies. We searched for the most relevant studies published until the end of September 2017...
2018: PloS One
https://www.readbyqxmd.com/read/30098998/developmental-smad6-loss-leads-to-blood-vessel-hemorrhage-and-disrupted-endothelial-cell-junctions
#3
Lyndsay A Wylie, Kevin P Mouillesseaux, Diana C Chong, Victoria L Bautch
The BMP pathway regulates developmental processes including angiogenesis, yet its signaling outputs are complex and context-dependent. Recently, we showed that SMAD6, an intracellular BMP inhibitor expressed in endothelial cells, decreases vessel sprouting and branching both in vitro and in zebrafish. Genetic deletion of SMAD6 in mice results in poorly characterized cardiovascular defects and lethality. Here, we analyzed the effects of SMAD6 loss on vascular function during murine development. SMAD6 was expressed in a subset of blood vessels throughout development, primarily in arteries, while expression outside of the vasculature was largely confined to developing cardiac valves with no obvious embryonic phenotype...
October 15, 2018: Developmental Biology
https://www.readbyqxmd.com/read/30091412/roles-of-talin2-in-traction-force-generation-tumor-metastasis-and-cardiovascular-integrity
#4
Lei Qi, Tomasz Kolodziej, Zenon Rajfur, Cai Huang
There are two vertebrate talin genes, TLN1 and TLN2, which encode talin1 and talin2. Talin1 governs integrin activation, thus regulating focal adhesion (FA) assembly, cell migration and invasion, but the biological function of talin2 remains to be elucidated and not too long ago talin2 was presumed to function redundantly with talin1. Recent studies have shown distinct differences between talin2 and talin1. The promoter of TLN2 is different from that of TLN1 in their size and binding to different transcription factors...
2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/30064358/the-evaluation-of-the-aortic-annulus-displacement-during-cardiac-cycle-using-magnetic-resonance-imaging
#5
Tomasz Plonek, Mikolaj Berezowski, Jacek Kurcz, Przemyslaw Podgorski, Marek Sąsiadek, Bartosz Rylski, Andrzej Mysiak, Marek Jasinski
BACKGROUND: The stress in the ascending aorta results from many biomechanical factors including the geometry of the vessel and its maximum dimensions, arterial blood pressure and longitudinal systolic stretching due to heart motion. The stretching of the ascending aorta resulting from the longitudinal displacement of the aortic annulus during the heart cycle has not been examined in the general population so far. The aim of the study is to evaluate this parameter using cardiovascular magnetic resonance (CMR) imaging in the general population in all age groups...
July 31, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/30052067/healthy-hearts-at-hectic-pace-from-daily-life-stress-to-abnormal-cardiomyocyte-function-and-arrhythmias
#6
Silvia Barbiero, Alberto Aimo, Vincenzo Castiglione, Alberto Giannoni, Giuseppe Vergaro, Claudio Passino, Michele Emdin
The hectic pace of contemporary life is a major source of acute and chronic stress, which may have a deleterious impact on body health . In the field of cardiovascular disease, acute emotional stress has been associated with coronary spasm and Takotsubo cardiomyopathy, whereas the manifestations of chronic stress have been overlooked, and most underlying pathophysiology remains to be elucidated. Chronic stress affects the neuronal circuitry composed of cortico-limbic structures and the nuclei regulating autonomic function, eliciting a sympatho-vagal imbalance, characterised by adrenergic activation and vagal withdrawal...
September 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/30036270/prevalence-of-proximal-ascending-aorta-and-target-organ-damage-in-hypertensive-patients-the-multicentric-argo-siia-project-aortic-remodelling-in-hypertension-of-the-italian-society-of-hypertension
#7
Alberto Milan, Daniela Degli Esposti, Massimo Salvetti, Raffaele Izzo, Antonella Moreo, Giacomo Pucci, Giulia Bruno, Ilenia Pareo, Angelo Parini, Anna Paini, Flora I Laurino, Paola Sormani, Raffaella Sgariglia, Eleonora Avenatti, Nicola De Luca
AIM: The aim of this study was to assess the prevalence of ascending aortic dilatation and to evaluate the possible association between proximal aorta dilatation and structural or functional markers of cardiac organ damage in hypertensive patients. BACKGROUND: Dilatation of the sinus of valsalva (SoV) is a common finding in clinical practice and it is associated with an increased cardiovascular risk in hypertensive patients: less is known about the dilatation prevalence of the subsequent portion, the proper ascending aorta and its relationship with cardiovascular organ damage...
July 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30030370/the-ccm1-ccm2-complex-controls-complementary-functions-of-rock1-and-rock2-that-are-required-for-endothelial-integrity
#8
Justyna Lisowska, Claudia Jasmin Rödel, Sandra Manet, Yekaterina A Miroshnikova, Cyril Boyault, Emmanuelle Planus, Richard De Mets, Hsiao-Hui Lee, Olivier Destaing, Hichem Mertani, Gwénola Boulday, Elisabeth Tournier-Lasserve, Martial Balland, Salim Abdelilah-Seyfried, Corinne Albiges-Rizo, Eva Faurobert
Endothelial integrity relies on a mechanical crosstalk between intercellular and cell-matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformation (CCM) genes. RhoA/ROCK-dependent cytoskeletal remodeling is central to the disease, as it causes unbalanced cell adhesion towards increased cell-extracellular matrix adhesions and destabilized cell-cell junctions. This study reveals that CCM proteins directly orchestrate ROCK1 and ROCK2 complementary roles on the mechanics of the endothelium...
August 13, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29988898/retroperitoneal-laparoscopic-non-dismembered-pyeloplasty-for-uretero-pelvic-junction-obstruction-due-to-crossing-vessels-a-matched-paired-analysis-and-review-of-literature
#9
Jens Rassweiler, Jan Klein, Ali Serdar Goezen
Objective: To compare laparoscopic Anderson-Hynes pyeloplasty (LAHP) and retroperitoneal laparoscopic YV-pyeloplasty (LRYVP) in ureteropelvic junction obstruction (UPJ) in presence of a crossing vessels (CV). Methods: Our database showed 380 UPJO-cases,who underwent laparoscopic retroperitoneal surgery during the last 2 decades including 206 non-dismembered LRYVP, 157 dismembered pyeloplasties LAHP, and 17 cases of laparoscopic ureterolysis. Among them 198 cases were suitable for a matched-pair (2:1) analysis comparing laparoscopic retroperitoneal non-dismembered LRYVP (Group 1, n  = 131) and dismembered LAHP (Group 2, n  = 67) in presence of a crossing vessel...
July 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29980408/perianesthetic-implications-and-considerations-for-myasthenia-gravis
#10
Virginia C Muckler, Jennifer M O'Brien, Stephen E Matson, Andi N Rice
Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease in which antibodies against the post-nicotinic acetylcholine receptor at the neuromuscular junction develop. Although the exact cause of MG remains unknown, the thymus is a common factor in many cases. Patients with underlying junctional disease, such as MG, have greater anesthesia-related risks because of their known predisposition toward prolonged muscle weakness. Medications given in the perioperative period, such as anesthetic agents, antibiotics, cardiovascular drugs, and corticosteroids, affect neuromuscular transmission that contributes to muscle weakness...
July 3, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29976618/adamts13-deficiency-shortens-the-lifespan-of-mice-with-experimental-diabetes
#11
Paola Cassis, Domenico Cerullo, Cristina Zanchi, Daniela Corna, Vincenzo Lionetti, Fabrizio Giordano, Rubina Novelli, Sara Conti, Valentina Casieri, Marco Matteucci, Monica Locatelli, Giulia Taraboletti, Sebastian Villa, Sara Gastoldi, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja
In patients with diabetes, impaired activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13), the plasma metalloprotease that cleaves highly thrombogenic VWF multimers is a major risk factor of cardiovascular events. Here, using Adamts13 -/- mice made diabetic by streptozotocin, we investigated the impact of the lack of ADAMTS13 on the development of diabetes-associated end-organ complications. Adamts13 -/- mice experienced shortened lifespan compared with their wild-type diabetic littermates...
July 5, 2018: Diabetes
https://www.readbyqxmd.com/read/29971234/the-transcriptomic-analysis-of-circulating-immune-cells-in-a-celiac-family-unveils-further-insights-into-disease-pathogenesis
#12
Rachele Ciccocioppo, Simona Panelli, Maria C Conti Bellocchi, Giuseppina C Cangemi, Luca Frulloni, Enrica Capelli, Gino R Corazza
Celiac disease (CD), the most common chronic enteropathy worldwide, is triggered and sustained by a dysregulated immune response to dietary gluten in genetically susceptible individuals. Up to date either the role of environmental factors and the pathways leading to mucosal damage have been only partially unraveled. Therefore, we seized the unique opportunity to study a naturally-occurring experimental model of a family composed of both parents suffering from CD (one on a gluten-free diet) and two non-celiac daughters...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29968241/-diagnosis-and-treatment-of-iatrogenic-colonoscopic-perforation
#13
Heng Wang, Ang Li, Xiaohui Shi, Xiaodong Xu, Hantao Wang, Hao Wang, Enda Yu
OBJECTIVE: To summarize the diagnosis and treatment of iatrogenic colonoscopic perforation (ICP). METHODS: Clinical data, treatment course and outcome of 17 patients who developed ICP following colonoscopic examination or operation at Department of Colorectal Surgery, Changhai Hospital from January 2000 to December 2013 were retrospectively analyzed. RESULTS: During above 13 years, a total of 127 106 patients underwent colonoscopic examination or operation, of whom 17 cases (0...
June 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29941006/water-ethanol-extract-of-cucumis-sativus-l-fruit-attenuates-lipopolysaccharide-induced-inflammatory-response-in-endothelial-cells
#14
Chiara Bernardini, Augusta Zannoni, Martina Bertocchi, Irvin Tubon, Mercedes Fernandez, Monica Forni
BACKGROUND: It is widely accepted the key role of endothelium in the onset of many chronic and acute vascular and cardiovascular diseases. In the last decade, traditional compounds utilized in "folk medicine" were considered with increasing interest to discover new bioactive molecules potentially effective in a wide range of diseases including cardiovascular ones. Since ancient times different parts of the Cucumis sativus L. plant were utilized in Ayurvedic medicine, among these, fruits were traditionally used to alleviate skin problem such as sunburn irritation and inflammation...
June 25, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29894844/atorvastatin-enhances-endothelial-adherens-junctions-through-promoting-ve-ptp-gene-transcription-and-reducing-ve-cadherin-y731-phosphorylation
#15
Zihe Huo, Ying Kong, Mei Meng, Zhifei Cao, Quansheng Zhou
Vascular endothelial protein tyrosine phosphatase (VE-PTP) is essential for endothelial cells (ECs) adherens junction and vascular homeostasis; however, the regulatory mechanism of VE-PTP transcription is unknown, and a drug able to promote VE-PTP expression in ECs has not yet been reported in the literature. In this study, we used human ECs as a model to explore small molecule compounds able to promote VE-PTP expression, and found that atorvastatin, a HMG-CoA reductase inhibitor widely used in the clinic to treat hypercholesterolemia-related cardiovascular diseases, strongly promoted VE-PTP transcription in ECs through activating the VE-PTP promoter and upregulating the expression of the transcription factor, specificity protein 1 (SP1)...
June 9, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29844145/modeling-superimposed-preeclampsia-using-ang-ii-angiotensin-ii-infusion-in-pregnant-stroke-prone-spontaneously-hypertensive-rats
#16
Hannah L Morgan, Elaine Butler, Shona Ritchie, Florian Herse, Ralf Dechend, Elisabeth Beattie, Martin W McBride, Delyth Graham
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and developing treatment options are crucial. The pregnant stroke-prone spontaneously hypertensive rat has impaired uteroplacental blood flow and abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats to mimic the increased cardiovascular stress associated with superimposed preeclampsia and examine the impact on the maternal cardiovascular system and fetal development...
July 2018: Hypertension
https://www.readbyqxmd.com/read/29795549/variability-in-pulmonary-vein-electrophysiology-and-fibrosis-determines-arrhythmia-susceptibility-and-dynamics
#17
Caroline H Roney, Jason D Bayer, Hubert Cochet, Marianna Meo, Rémi Dubois, Pierre Jaïs, Edward J Vigmond
Success rates for catheter ablation of persistent atrial fibrillation patients are currently low; however, there is a subset of patients for whom electrical isolation of the pulmonary veins alone is a successful treatment strategy. It is difficult to identify these patients because there are a multitude of factors affecting arrhythmia susceptibility and maintenance, and the individual contributions of these factors are difficult to determine clinically. We hypothesised that the combination of pulmonary vein (PV) electrophysiology and atrial body fibrosis determine driver location and effectiveness of pulmonary vein isolation (PVI)...
May 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29778719/effect-of-heptanol-and-ethanol-on-excitation-wave-propagation-in-a-neonatal-rat-ventricular-myocyte-monolayer
#18
A D Podgurskaya, V A Tsvelaya, S R Frolova, I Y Kalita, N N Kudryashova, K I Agladze
In this work, the action of heptanol and ethanol was investigated in a two-dimensional (2D) model of cardiac tissue: the neonatal rat ventricular myocyte monolayer. Heptanol is known in electrophysiology as a gap junction uncoupler but may also inhibit voltage-gated ionic channels. Ethanol is often associated with the occurrence of arrhythmias. These substances influence sodium, calcium, and potassium channels, but the complete mechanism of action of heptanol and ethanol remains unknown. The optical mapping method was used to measure conduction velocities (CVs) in concentrations of 0...
September 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29753823/analysis-of-differentially-changed-gene-expression-in-ea-hy926-human-endothelial-cell-after-exposure-of-fine-particulate-matter-on-the-basis-of-microarray-profile
#19
Yan Wang, Lilin Xiong, Tianshu Wu, Ting Zhang, Lu Kong, Yuying Xue, Meng Tang
Epidemiological studies have illustrated that PM2.5 is closely related to cardiovascular disease (CVD), but underlying toxicological mechanisms are not yet clear. The main purpose of this study is to disclose the potential biological mechanisms responsible for PM2.5-dependent adverse cardiovascular outcomes through the appliance of genome-wide transcription microarray. From results, compared with the control group, there are 97 genes significantly altered in 2.5 μg/cm2 PM2.5 treated group and 440 differentially expressed genes in 10 μg/cm2 group...
September 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29751293/the-potential-atheroprotective-role-of-plant-mir156a-as-a-repressor-of-monocyte-recruitment-on-inflamed-human-endothelial-cells
#20
Dongxia Hou, Fangfang He, Lina Ma, Minghui Cao, Zhen Zhou, Zhe Wei, Yunxing Xue, Xiaolin Sang, Hoshun Chong, Congcong Tian, Shasha Zheng, Jing Li, Ke Zen, Xi Chen, Zhi Hong, Chen-Yu Zhang, Xiaohong Jiang
MicroRNAs have become the spotlight of the biological community for more than a decade, but we are only now beginning to understand their functions. The detection of stably expressed endogenous microRNAs in human blood suggests that these circulating miRNAs can mediate intercellular communication. Our previous study reported the surprising finding that exogenous rice MIR168a could regulate liver low-density lipoprotein receptor adapter protein 1 (LDLRAP1) gene expression in mice. Here, we show that plant MIR156a, which is abundantly expressed in dietary green veggies, also stably presents in healthy human serum...
July 2018: Journal of Nutritional Biochemistry
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