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https://www.readbyqxmd.com/read/29141969/cardiovascular-and-antiobesity-effects-of-resveratrol-mediated-through-the-gut-microbiota
#1
REVIEW
Julia K Bird, Daniel Raederstorff, Peter Weber, Robert E Steinert
Encouraging scientific research into the health effects of dietary bioactive resveratrol has been confounded by its rapid first-pass metabolism, which leads to low in vivo bioavailability. Preliminary studies have shown that resveratrol can modulate gut microbiota composition, undergo biotransformation to active metabolites via the intestinal microbiota, or affect gut barrier function. In rodents, resveratrol can modify the relative Bacteroidetes:Firmicutes ratio and reverse the gut microbial dysbiosis caused by a high-fat diet...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29137243/ionising-radiation-increases-permeability-of-endothelium-through-adam10-mediated-cleavage-of-ve-cadherin
#2
Sylwia Kabacik, Ken Raj
The association between ionising radiation (IR) exposure and risk of cardiovascular diseases (CVD) is well documented, but the underlying mechanism is still poorly understood. As atherosclerotic plaques are the most common cause of CVD, we investigated the effects of IR on one of the critical parameters for atherosclerotic plaque formation - endothelium permeability to macromolecules. We used endothelial cells from human coronary artery as a model of the endothelial layer. Our results show that exposure of this endothelial layer to IR increased its permeability to macromolecules of various sizes in a dose-dependent manner...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133170/hydronephrosis-and-crossing-vessels-in-children-optimization-of-diagnostic-therapeutic-pathway-and-analysis-of-color-doppler-ultrasound-and-magnetic-resonance-urography-diagnostic-accuracy
#3
M C Y Wong, G Piaggio, M B Damasio, C Molinelli, S M Ferretti, A Pistorio, G Ghiggeri, M L Degl'Innocenti, A Canepa, V Incarbone, G Mattioli
INTRODUCTION: Ureteropelvic junction obstruction (UPJO) is one of the most frequent urological diseases affecting the pediatric population. It can be due to both intrinsic stenosis of the junction and extrinsic causes such as the presence of crossing vessels (CVs), which can be detected by color Doppler ultrasound (CD-US). Magnetic resonance urography (MRU) is a good alternative, but sedation and infusion of a contrast agent are required. OBJECTIVE: The aim of this study was to analyze the diagnostic accuracy of CD-US and MRU in visualizing CVs in pediatric hydronephrosis, in order to decide the correct diagnostic pathway in the pre-operative phase...
October 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29129522/increasing-the-safety-of-surgical-treatment-for-complex-cranio-vertebral-anomalies-using-customized-3d-printed-models
#4
Kataria Rashim, K Verma Pawan, V D Sinha
Surgery for the Cranio-vertebral (CV) junction anomalies using top loading subocciput (C0)/C1-C2 screws is difficult and requires high level of skill and expertise. This is because of complex abnormal anatomy in that region and other issues including the instrumentation. Thorough knowledge of the 3D anatomy of the Craniovertebral junction of the patient is essential for favourable outcome. The customised 3D printed model of CV junction region of the patient can be used for studying the anatomy and relationship of vertebral artery to the C1-C2 joint before the actual surgery...
November 9, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29120015/ascending-aortic-remodelling-in-fabry-disease-after-long-term-enzyme-replacement-therapy
#5
Pierre Monney, Salah Dine Qanadli, Steven Hajdu, Christel Tran, Juerg Schwitter, Olivier Dormond, Frédéric Barbey
BACKGROUND: Previous cross-sectional studies reported a high prevalence of ascending aorta dilations/aneurysms in male adults with Fabry disease, independently of cardiovascular risk factors. AIMS OF THE STUDY: To characterise the remodelling of the ascending aorta in classic Fabry disease under long-term enzyme replacement therapy. METHODS: Diameter of the ascending aorta was measured with magnetic resonance imaging at the sino-tubular junction (STJ), and proximal (pAsAo), and distal ascending aorta (dAsAo) at baseline, and after 5 and 10 years of enzyme replacement therapy in 15 adult Fabry patients (10 males; 5 females)...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29104646/reduced-gja5-expression-in-arterial-endothelial-cells-impairs-arteriogenesis-during-acute-ischemic-cardiovascular-disease
#6
Xiang-Jun Lu, Hai-Tao Wang
The aim of the present study was to investigate the functional role of gap junction protein α 5 (Gja5) in arterial endothelial cells in the arteriogenesis that occurs during acute ischemic cardiovascular disease. Gja5 knockout mice and the femoral artery occlusion (FAO) model were used in the current study. Perfusions of both hindlimbs were obtained separately prior to FAO, immediately following FAO and 1, 3, 7, 14 and 21 days after FAO using a Laser Doppler Flow Imager. Genetic evidence concerning the gastrocnemicus (GC) muscle was collected by reverse transcription-quantitative polymerase chain reaction...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29077057/the-role-of-gap-junction-mediated-endothelial-cell-cell-interaction-in-the-crosstalk-between-inflammation-and-blood-coagulation
#7
REVIEW
Takayuki Okamoto, Koji Suzuki
Endothelial cells (ECs) play a pivotal role in the crosstalk between blood coagulation and inflammation. Endothelial cellular dysfunction underlies the development of vascular inflammatory diseases. Recent studies have revealed that aberrant gap junctions (GJs) and connexin (Cx) hemichannels participate in the progression of cardiovascular diseases such as cardiac infarction, hypertension and atherosclerosis. ECs can communicate with adjacent ECs, vascular smooth muscle cells, leukocytes and platelets via GJs and Cx channels...
October 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29058597/correction-to-disruption-of-endothelial-adherens-junctions-by-high-glucose-is-mediated-by-protein-kinase-c-%C3%AE-dependent-vascular-endothelial-cadherin-tyrosine-phosphorylation
#8
Mehran Haidari, Wei Zhang, James T Willerson, Richard A F Dixon
This article was unintentionally published twice in this journal, by the same authors. The following should be considered the version of record and used for citation purposes: "Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon, Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation, Cardiovascular Diabetology, Volume 13, Issue 1, doi: 10.1186/1475-2840-13-112 ". The duplicate "Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon, Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation, Cardiovascular Diabetology, Volume 13, Issue 1, doi: 10...
October 20, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29057883/non-muscular-myosin-light-chain-kinase-triggers-intermittent-hypoxia-induced-interleukin-6-release-endothelial-dysfunction-and-permeability
#9
Sylvain Recoquillon, Manuel Gómez-Guzmán, Marion Rodier, Camille Koffi, Mathieu Nitiéma, Frédéric Gagnadoux, M Carmen Martínez, Ramaroson Andriantsitohaina
Obstructive sleep apnea is characterized by intermittent hypoxia (IH) which alters endothelial function, induces inflammation and accelerates atherosclerosis-induced cardiovascular diseases. The non-muscular myosin light chain kinase (nmMLCK) isoform contributes to endothelial cell-cell junction opening. Deletion of nmMLCK protects mice from death in septic shock models and prevents atherosclerosis in high-fat diet-fed mice. The aim of the study was to analyze the implication of nmMLCK in IH-induced vascular inflammation...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29018633/a-software-tool-for-heart-avj-motion-tracking-using-cine-cardiovascular-magnetic-resonance-images
#10
Pengdong Xiao, Xiaodan Zhao, Shuang Leng, Ru San Tan, Philip Wong, Liang Zhong
One important index to assess left ventricular diastolic function is the quantitative measurement of atrioventricular junction (AVJ) motion in one cardiac cycle including systole and diastole. The best way to perform the measurement is to use a software tool that can conduct AVJ motion tracking from cine cardiovascular magnetic resonance (CMR) images. In this paper, a software tool for this purpose is presented by using the insight segmentation and registration toolkit (ITK), the visualization toolkit (VTK), and Qt...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28962524/cardiac-and-metabolic-effects-of-dietary-selenomethionine-exposure-in-adult-zebrafish
#11
Connor M Pettem, Lynn P Weber, David M Janz
Selenium (Se) is an essential micronutrient involved in important metabolic functions for all vertebrate species. As Se is reported to have a narrow margin between essentiality and toxicity, there is growing concern surrounding the adverse effects of elevated Se exposure caused by anthropogenic activities. Recent studies have reported that elevated dietary exposure of fish to selenomethionine (Se-Met) can alter aerobic metabolic capacity, energetics and swimming performance. This study aims to further investigate mechanisms of sublethal Se-Met toxicity, particularly potential underlying cardiovascular implications of chronic exposure to environmentally relevant concentrations of dietary Se-Met in adult zebrafish (Danio rerio)...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28955382/atrial-fibrillation-in-heart-failure-a-therapeutic-challenge-of-our-times
#12
REVIEW
Syeda Atiqa Batul, Rakesh Gopinathannair
Atrial fibrillation (AF) and heart failure (HF) are growing cardiovascular disease epidemics worldwide. There has been an exponential increase in the prevalence of AF and HF correlating with an increased burden of cardiac risk factors and improved survival rates in patients with structural heart disease. AF is associated with adverse prognostic outcomes in HF and is most evident in mild-to-moderate left ventricular (LV) dysfunction where the loss of "atrial kick" translates into poorer quality of life and increased mortality...
September 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28948327/abnormal-longitudinal-growth-of-the-aorta-in-children-with-familial-bicuspid-aortic-valve
#13
Holly Nadorlik, Jessica L Bowman, Sara Fitzgerald-Butt, May Ling Mah, Kim L McBride, John P Kovalchin, Vidu Garg
Bicuspid aortic valve (BAV) is the most common type of congenital heart defect (CHD) and is associated with clinically significant cardiovascular complications including valve calcification and ascending aortopathy (AscAo), predominantly occurring in adulthood. While a limited number of genetic etiologies for BAV have been defined, family members of affected individuals display BAV along with other left-sided CHD. This has led to guidelines from the American Heart Association and American College of Cardiology that recommend echocardiographic screening of first-degree relatives of affected adults...
September 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28931622/connexins-in-cardiovascular-and-neurovascular-health-and-disease-pharmacological-implications
#14
REVIEW
Luc Leybaert, Paul D Lampe, Stefan Dhein, Brenda R Kwak, Peter Ferdinandy, Eric C Beyer, Dale W Laird, Christian C Naus, Colin R Green, Rainer Schulz
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane hemichannels and as intercellular gap junction channels that directly connect cells. In the heart, gap junction channels electrically connect myocytes and specialized conductive tissues to coordinate the atrial and ventricular contraction/relaxation cycles and pump function. In blood vessels, these channels facilitate long-distance endothelial cell communication, synchronize smooth muscle cell contraction, and support endothelial-smooth muscle cell communication...
October 2017: Pharmacological Reviews
https://www.readbyqxmd.com/read/28923269/dpp-4-inhibition-protects-human-umbilical-vein-endothelial-cells-from-hypoxia-induced-vascular-barrier-impairment
#15
Naoko Hashimoto, Kento Ikuma, Yui Konno, Masanori Hirose, Hiroyuki Tadokoro, Hiroshi Hasegawa, Yoshio Kobayashi, Hiroyuki Takano
Dipeptidyl peptidase-4 (DPP-4) inhibitors are relatively new class of anti-diabetic drugs. Some protective effects of DPP-4 on cardiovascular disease have been described independently from glucose-lowering effect. However, the detailed mechanisms by which DPP-4 inhibitors exert on endothelial cells remain elusive. The purpose of this research was to determine the effects of DPP-4 inhibitor on endothelial barrier function. Human umbilical vein endothelial cells (HUVECs) were cultured and exposed to hypoxia in the presence or absence of Diprotin A, a DPP-4 inhibitor...
September 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28912179/classification-epidemiology-and-global-burden-of-cardiomyopathies
#16
REVIEW
William J McKenna, Barry J Maron, Gaetano Thiene
In the past 25 years, major advances were achieved in the nosography of cardiomyopathies, influencing the definition and taxonomy of this important chapter of cardiovascular disease. Nearly, 50% of patients dying suddenly in childhood or adolescence or undergoing cardiac transplantation are affected by cardiomyopathies. Novel cardiomyopathies have been discovered (arrhythmogenic, restrictive, and noncompacted) and added to update the World Health Organization classification. Myocarditis has also been named inflammatory cardiomyopathy...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28901235/low-dose-computed-tomographic-imaging-of-partial-anomalous-pulmonary-venous-connection-in-children
#17
Aysel Türkvatan, Hasan Tahsin Tola, Neşe Kutlutürk, Alper Güzeltaş, Yakup Ergül
BACKGROUND: In this study, we aimed to determine lobar distribution, drainage sites, and associated cardiovascular anomalies of partial anomalous pulmonary venous connection in pediatric patients using low-dose multidetector computed tomographic angiography. METHODS: Sixty-one cases (27 female, mean age: 4.7 years) with partial anomalous pulmonary venous connection diagnosed by multidetector computed tomographic angiography were included in this study. In all patients, multidetector computed tomographic angiography examinations were performed using dual-source 256-slice scanner without sedation...
September 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28859294/ccaat-enhancer-binding-protein-delta-promotes-intracellular-lipid-accumulation-in-m1-macrophages-of-vascular-lesions
#18
Hong-Yue Lai, Ling-Wei Hsu, Hsin-Hwa Tsai, Yu-Chih Lo, Shang-Hsun Yang, Ping-Yen Liu, Ju-Ming Wang
Aims: Lipid homeostasis is reprogrammed in the presence of inflammation, which results in excessive lipid accumulation in macrophages, and leads to the formation of lipid-laden foam cells. We aimed to link an inflammation-responsive transcription factor CCAAT/enhancer-binding protein delta (CEBPD) with polarized macrophages and dissect its contribution to lipid accumulation. Methods and results: We found that CEBPD protein colocalized with macrophages in human and mouse (C57BL/6, Apoe-/-) atherosclerotic plaques and that Cebpd deficiency in bone marrow cells suppressed atherosclerotic lesions in hyperlipidemic Apoe-/- mice...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28843154/numerical-analysis-of-wall-shear-stress-in-ascending-aorta-before-tearing-in-type-a-aortic-dissection
#19
Qingzhuo Chi, Ying He, Yong Luan, Kairong Qin, Lizhong Mu
Although the incidence of many cardiovascular diseases has declined as medical treatments have improved, the prevalence of aortic dissection (AD) has increased. Compared to type B dissections, type A dissections are more severe, and most patients with type A dissections require surgical treatment. The objective of this study was to investigate the relationships between the wall shear stress (WSS) on the aortic endothelium and the frequent tearing positions using computational fluid dynamics. Five type A dissection cases and two normal aortas were included in the study...
August 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28835570/amp-activated-protein-kinase-a-therapeutic-target-in-intestinal-diseases
#20
REVIEW
Xiaofei Sun, Mei-Jun Zhu
Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, nutrient transporters, autophagy and apoptosis, and suppresses inflammation and carcinogenesis in the intestine, indicating an essential role of AMPK in intestinal health. AMPK inactivation is an aetiological factor in intestinal dysfunctions...
August 2017: Open Biology
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