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https://www.readbyqxmd.com/read/28714317/prospective-observational-study-to-determine-the-accuracy-of-first-trimester-serum-biomarkers-and-uterine-artery-dopplers-in-combination-with-maternal-characteristics-and-arteriography-for-the-prediction-of-women-at-risk-of-preeclampsia-and-other-adverse-pregnancy
#1
Rebecca Allen, Joseph Aquilina
OBJECTIVES: To assess the efficacy of biomarkers, arteriography and uterine artery Dopplers for predicting hypertensive disease of pregnancy, small for gestational age and stillbirth. METHODS: This was a prospective first trimester study. Ultrasound was used to assess uterine artery Doppler. Maternal arteriography performed and serum taken for measurement of placental growth factor (PlGF), alpha fetoprotein (AFP), pregnancy associated plasma protein (PAPP-A) and beta human chorionic gonadotrophin (β-hCG) levels...
July 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28702183/induction-of-autoimmune-abdominal-aortic-aneurysm-in-pigs-a-novel-large-animal-model
#2
Sara Schødt Riber, Mulham Ali, Sara Hveding Bergseth, Jane Stubbe, Michael Stenger, Carsten Behr-Rasmussen, Jes Sanddal Lindholt
BACKGROUND: Abdominal aortic aneurysm (AAA) is a common disease with a high mortality. Many animal models have been developed to further understand the pathogenesis of the disease, but no large animal model has been developed to investigate the autoimmune aspect of AAA formation. The aim of this study was to develop a large animal model for abdominal aortic aneurysm induction through autoimmunity by performing sheep-to-pig xenotransplantation. METHODS: Six pigs underwent a xenotransplantation procedure where the infrarenal porcine aorta was replaced by a decellularized sheep aorta...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28697490/the-influence-of-blood-pressure-on-fetal-aortic-distensibility-an-animal-validation-study
#3
Christoph Wohlmuth, Kenneth J Moise, Ramesha Papanna, Ciprian Gheorghe, Anthony Johnson, Yisel Morales, Helena M Gardiner
BACKGROUND/AIMS: Aortic distension waveforms describe the change in diameter or cross-sectional area over the cardiac cycle. We aimed to validate the association of aortic fractional area change (AFAC) with blood pressure (BP) in a fetal lamb model. METHODS: Four pregnant ewes underwent open fetal surgery under general anesthesia at 107-120 gestational days. A 4-Fr catheter was introduced into the fetal femoral artery and vein, or the carotid artery and jugular vein...
July 12, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28689953/the-significance-of-the-angle-between-superior-mesenteric-artery-and-aorta-in-spontaneous-isolated-superior-mesenteric-artery-dissection
#4
Zhongyin Wu, Jie Yi, Huanming Xu, Wei Guo, Lijun Wang, Duanduan Chen, Jiang Xiong
OBJECTIVE: To assess the significance of the angle between superior mesenteric artery (SMA) and distal aorta in spontaneous isolated superior mesenteric artery dissection (SISMAD) by clinical and biomechanical analyses. METHODS: 37 patients with SISMAD (one asymptomatic) and 148 controls (1:4 matched for age [mean, 50.2 years], gender [92% male], and body mass index; and being ruled out for arterial disease) underwent aortic computed tomography angiography. SMA-distal aorta angle, measured on sagittal plane, was compared along with baseline characteristics (body mass index, smoking history and comorbidities) between groups; and assessed as tool to evaluate SISMAD risk after stratification into four angle-interval categories...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28672932/intravascular-application-of-electrocautery-in-a-rabbit-model-of-abdominal-aortic-endarterectomy
#5
Chuan Wang, Yi Xin, Na Li, Diankun Li, Jingxing Li, Chengxiong Gu
Effective therapies for preventing perioperative complications such as thrombosis and inflammation after coronary endarterectomy (CE) are lacking. Electrocoagulation electrotomes have been routinely used in surgery for their cutting, clotting, and hemostatic properties. As strong flattening tools, their electrocautery function may prevent mechanical intimal-adventitial injury to arterial circulation and attenuate stenosis. The present study investigated the effects of intravascular application of electrocautery on ameliorating inflammation and thrombosis in a rabbit model of abdominal aortic endarterectomy...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28665206/primary-aorto-enteric-fistula-as-a-rare-cause-of-massive-gastrointestinal-haemorrhage
#6
Christian-Alexander Behrendt, Sabine Wipper, Sebastian E Debus, Yskert von Kodolitsch, Klaus Püschel, Michael Kammal, Anna Kammal
The incidence of primary aorto-enteric fistula (PAEF) is low with only few case reports and case series published. Depending on the location of the PAEF, the perforation leads to upper or lower gastrointestinal haemorrhages. We conducted a MEDLINE search according to the PRISMA statement. Articles with publication dates from 2000 to 2016 were included and present an own case report. We considered all case reports and series reporting on PAEF and identified 85 individual patients from 32 case reports and five case series...
June 30, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28664608/intima-media-thickness-at-different-arterial-segments-in-pediatric-type-1-diabetes-patients-and-its-relationship-with-advanced-glycation-end-products
#7
Christian Lilje, Julie C Cronan, Elridge J Schwartzenburg, Elizabeth M Owers, Patrice Clesi, Ricardo Gomez, Sarah Stender, James Hempe, Stuart A Chalew, Jeffrey P Cardinale
BACKGROUND: Patients with type 1 diabetes mellitus (T1DM) are at risk for premature atherosclerosis (AS), which has its origin in childhood. Carotid intima-media thickness (IMT) is an established surrogate marker for subclinical AS in adults. The first macroscopically detectable AS changes, however, begin in the abdominal aorta. Advanced glycation end products (AGE) predict microvascular complications in diabetes. OBJECTIVES: To assess the sensitivity for early macrovascular changes of brachial, femoral, and aortic IMT compared to conventional carotid IMT in pediatric T1DM patients ; and the relationship of IMT with AGE...
June 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28648794/in%C3%A2-vitro-and-in%C3%A2-vivo-evaluation-of-a-small-caliber-coaxial-electrospun-vascular-graft-loaded-with-heparin-and-vegf
#8
Yun-Tao Hu, Xu-Dong Pan, Jun Zheng, Wei-Guo Ma, Li-Zhong Sun
INTRODUCTION: To date, clinically available expanded polytetrafluoro-ethylene (ePTFE) vascular grafts are suboptimal for reconstructing small caliber (D < 6 mm) arteries, owing to thrombosis in early and restenosis in late stage. Our aim in this preliminary study was to fabricate a nano-fibrous vascular graft which was biofunctionalized with VEGF165 and heparin. The short term performance was evaluated both in vitro and in vivo. METHOD: Four-mm caliber grafts were prepared by the coaxial-elctrospun technique, which consisted of poly(l-lactide-co-caprolactone) [P(LLA-CL)] collagen and elastin...
June 22, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28648482/comparison-of-intravascular-ultrasound-and-centerline-computed-tomography-determined-aortic-diameters-during-thoracic-endovascular-aortic-repair
#9
Sukgu M Han, Ramsey S Elsayed, Sung W Ham, Anuj Mahajan, Fernando Fleischman, Vincent L Rowe, Mark J Cunningham, Fred A Weaver
BACKGROUND: Accurate sizing of stent grafts during thoracic endovascular aortic repair (TEVAR) is critical for a successful outcome. Centerline measurements using three-dimensional reconstruction of preoperative computed tomography angiography (CTA) is the current standard for stent graft sizing. However, this technique is predicated on an idealized straightened aorta and does not account for the variability in the aortic diameter during the cardiac cycle or the overall status of the patient's volume...
June 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28646121/at1-receptor-blockade-attenuates-outward-aortic-remodeling-associated-with-diet-induced-obesity-in-mice
#10
Friedrich Krueger, Kai Kappert, Anna Foryst-Ludwig, Frederike Kramer, Markus Clemenz, Aleksandra Grzesiak, Manuela Sommerfeld, Jan Paul Bernhard Frese, Andreas Greiner, Ulrich Kintscher, Thomas Unger, Elena Kaschina
The renin-angiotensin-system and obesity have been implicated in vascular outward remodeling, including aneurysms, but the precise mechanisms are yet not understood. We investigated the effect of the angiotensin AT1-receptor antagonist telmisartan on aortic outward remodeling in a diet-induced obesity-model in mice. C57/Black6J mice were fed with either a low-fat diet (LFD), or a high-fat diet (HFD) for 14 weeks. One group of HFD-mice was additionally exposed to telmisartan (3mg/kg/d) for the last 4 weeks. HFD led to aortic outward remodeling, characterized by increased proteolysis, along with structural changes, such as fragmentation of elastic fibres, and decreased elastin content...
June 23, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28645796/preclinical-testing-of-frequency-tunable-capacitive-micromachined-ultrasonic-transducer-probe-prototypes
#11
Martin Pekař, Alexander F Kolen, Harm Belt, Frank van Heesch, Nenad Mihajlović, Imo E Hoefer, Tamas Szili-Török, Hendrik J Vos, Johan G Bosch, Gijs van Soest, Antonius F W van der Steen
In intracardiac echocardiography (ICE) it may be beneficial to generate ultrasound images acquired at multiple frequencies, having the possibility of high penetration or high-resolution imaging in a single device. The objective of the presented work is to test two frequency-tunable probe prototypes in a preclinical setting: a rigid probe having a diameter of 11 mm and a new flexible and steerable 12-Fr ICE catheter. Both probes feature a forward-looking 32-element capacitive micromachined ultrasonic transducer array (aperture of 2 × 2 mm(2)) operated in collapse mode, which allows for frequency tuning in the 6-MHz-18-MHz range...
June 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28640847/heart-rate-lowering-treatment-leads-to-a-reduction-in-vulnerable-plaque-features-in-atherosclerotic-rabbits
#12
Raf H M van Hoof, Evelien Hermeling, Judith C Sluimer, Julie Salzmann, Arnold P G Hoeks, Jérôme Roussel, Mat J A P Daemen, Harry Struijker-Boudier, Joachim E Wildberger, Sylvia Heeneman, M Eline Kooi
OBJECTIVE: To investigate the effect of a heart rate (HR) lowering agent (Ivabradine) on features of atherosclerotic plaque vulnerability with magnetic resonance imaging (MRI), ultrasound imaging, and histology. APPROACH AND RESULTS: Atherosclerosis was induced in the abdominal aorta of 19 rabbits. Nine rabbits were treated with Ivabradine (17 mg/kg/day) during the entire study period. At week 14, imaging was performed. Plaque size was quantified on contrast-enhanced T1-weighted MR images...
2017: PloS One
https://www.readbyqxmd.com/read/28620160/small-diameter-hybrid-vascular-grafts-composed-of-polycaprolactone-and-polydioxanone-fibers
#13
Yiwa Pan, Xin Zhou, Yongzhen Wei, Qiuying Zhang, Ting Wang, Meifeng Zhu, Wen Li, Rui Huang, Ruming Liu, Jingrui Chen, Guanwei Fan, Kai Wang, Deling Kong, Qiang Zhao
Electrospun polycaprolactone (PCL) vascular grafts showed good mechanical properties and patency. However, the slow degradation of PCL limited vascular regeneration in the graft. Polydioxanone (PDS) is a biodegradable polymer with high mechanical strength and moderate degradation rate in vivo. In this study, a small-diameter hybrid vascular graft was prepared by co-electrospinning PCL and PDS fibers. The incorporation of PDS improves mechanical properties, hydrophilicity of the hybrid grafts compared to PCL grafts...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28593006/ultrasound-detection-of-aortoenteric-fistula-in-a-patient-with-sepsis
#14
Tiziano Perrone, Chiara Pagani, Elisa Eleonora Mossolani
We report a case of an 81-year-old man, hospitalized for sepsis unresponsive to targeted antibiotic therapy, who underwent abdominal aortic aneurysmectomy with stent placement before 12 years. Point-of-care ultrasound examination showed the presence of a voluminous and inhomogeneous lesion adjacent to the anterior wall of aortic bifurcation with pulsatile flow from the aorta into the lesion, highlighted by Color-Doppler, and peripheral (closely with intestinal loops) floating hyperechoic spots marked by posterior comet tail artifact, suggestive for the presence of air bubbles...
June 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28577841/aortic-atheroma-increases-the-risk-of-long-term-mortality-in-20-000-patients
#15
Carolyn Goldberg Butler, Jamahal Maeng Ho Luxford, Chuan-Chin Huang, Julius I Ejiofor, James D Rawn, Kerry Wilusz, John A Fox, Stanton K Shernan, Jochen Daniel Muehlschlegel
BACKGROUND: The association between long-term survival and aortic atheroma in cardiac surgical patients has not been comprehensively investigated. In this study we determine the relation between grade of atheroma and the risk of long-term mortality in a retrospective cohort of more than 20,000 patients undergoing cardiac operation during a 20-year period. METHODS: We included 22,304 consecutive intraoperative transesophageal and epiaortic ultrasound examinations performed at Brigham and Women's Hospital between 1995 and 2014, with long-term follow-up...
June 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28569051/the-chances-that-an-emergency-physician-will-demonstrate-three-abdominal-aortic-aneurysms-by-ultrasound-in-the-emergency-department-for-credentialing-a-statistician-s-view
#16
Kevin H Chu, Anita Pelecanos, Nathan J Brown, Anthony Ft Brown
The Australasian College for Emergency Medicine requires 15 proctored examinations of the aorta for credentialing in ultrasonography for abdominal aortic aneurysm (AAA). Furthermore, at least three examinations need to be positive for an aneurysm. In the ED where AAA presentations are sporadic, what are the chances that an emergency physician (EP) will have the opportunity to demonstrate three AAAs in the next 12 months? The probability of an event occurring within a given time-frame can be modelled by the Poisson distribution...
May 31, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28559781/pancreatic-squamous-cell-carcinoma
#17
Seyed Hassan Abedi, Alireza Ahmadzadeh, Amir Houshang Mohammad Alizadeh
Pancreatic squamous cell carcinoma (SCC) is a rare event. Here, we present a 56-year-old man with pancreatic SCC. Imaging methods demonstrated a hypodense mass at the head and trunk of the pancreas. Also, some lymphadenopathy has been seen around the pancreas and para-aorta. The mass created pressure and encasement on the celiac trunk, portal vein, and arteries of the liver and spleen. Endoscopic ultrasound showed a mass lesion of 45-37 mm (mixed echoic) at the trunk of the pancreas. Histological examination of the endoscopic ultrasound-guided fine needle aspiration specimen confirmed the diagnosis of SCC...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28538448/ultrasonography-for-preoperative-diagnosis-of-retroperitoneal-fibrosis
#18
Sheng-Jiang Chen, Ling Qin, Yu-Juan Xie, Jian-Ping Zhu, Qiang Zhang, Mei Chen
This study aimed to assess the application of ultrasonography for preoperative diagnosis of retroperitoneal fibrosis (RPF). A total of 51 patients with clinically suspected RPF underwent transabdominal ultrasonography and ultrasound-guided histopathologic biopsy (tAU-UGHB). Retroperitoneal fibrosis was diagnosed in 35 patients; of these, 31 cases (88.6%) received a diagnosis using tAU-UGHB. The ultrasonographic images mainly showed solid, irregular isoechoic masses, which were present behind the retroperitoneum and surrounded the abdominal aorta, inferior vena cava, and ureters and had clear borders with the encapsulated structures...
June 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28515742/the-use-of-intraoperative-epiaortic-ultrasonography-in-monitoring-patients-over-75-years-old-treated-with-aortic-valve-replacement
#19
Tomasz Niklewski, Michał Zembala, Dariusz Puszczewicz, Paweł Nadziakiewicz, Wojciech Karolak, Marian Zembala
INTRODUCTION: Epiaortic ultrasound scanning (EAS) extended the use of ultrasound to the intraoperative diagnosis of aortic pathology. Surgical palpation of the ascending aorta underestimates the presence and severity of atherosclerotic plaques. Epiaortic ultrasound scanning has been used as an adjunct to transesophageal echocardiography (TEE) or as a primary direct diagnostic tool for imaging the ascending aorta as well as the aortic arch, which gained prominence as part of a multipronged intraoperative strategy to reduce atherosclerotic emboli...
March 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28514894/successful-repair-of-acute-type-b-and-retrograde-type-a-aortic-dissection-with-kidney-ischemia
#20
Jeko M Madjarov, Michael G Katz, Hector Crespo-Soto, Svetozar Madzharov, Timothy Roush, Francis Robicsek
Acute dissection of thoracic aorta carries a risk of renal ischemia followed by the development of a kidney failure. The optimal surgical and nonsurgical management of these patients, timing of intervention, and the factors predicting renal recovery are not well delineated and remain controversial. We present a case of acute type B thoracic aortic dissection with left kidney ischemia. Evaluation of renal function was performed by the means of internationally accepted Risk, Injury, Failure, Loss of kidney function, End stage kidney disease and Acute Kidney Injury Network classifications for acute kidney injury, renal duplex sonography, and intravascular ultrasound that demonstrated left renal artery dissection with a flap completely compressing the true lumen...
January 1, 2017: Vascular and Endovascular Surgery
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