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https://www.readbyqxmd.com/read/29142190/detection-of-atherosclerotic-plaques-in-the-rabbit-aorta-using-ultrasound-microbubbles-conjugated-to-interleukin-18-antibodies
#1
Zhen-Zhen Jiang, Xia-Tian Liu, Cai-Ye Ma, Cong He, Xing-Yun Li, Chuan-Lin Hou, Zu-Sheng Cheng, Guo-Yuan Xia
BACKGROUND The purpose of the study was to investigate the ability of microbubbles (MBs) targeting interleukin-18 (IL-18) to detect plaques in a rabbit atherosclerotic plaque model. MATERIAL AND METHODS A rabbit atherosclerotic plaque model was established. The locations of the atherosclerotic plaques were verified by two-dimensional scanning and color Doppler flow imaging. An IL-18 antibody was conjugated to naked MBs (MBc) using the biotin-streptavidin conjugation method, resulting in the formation of MBIL-18...
November 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29132574/major-abdominal-trauma-critical-decisions-and-new-frontiers-in-management
#2
REVIEW
Megan Brenner, Christopher Hicks
A standardized approach should be used with a patient with abdominal trauma, including primary and secondary surveys, followed by additional diagnostic testing as indicated. Specific factors can make the diagnosis of serious abdominal trauma challenging, particularly in the face of multiple and severe injuries, unknown mechanism of injury, altered mental status, and impending or complete cardiac arrest. Advances in technology in diagnosis and/or treatment with ultrasound, helical computed tomography, and resuscitative endovascular balloon occlusion of the aorta (REBOA) have significantly advanced trauma care, and are still the focus of current and ongoing investigations...
February 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29120452/vascular-aging-and-cardiac-maladaptation-in-growth-restricted-preterm-infants
#3
A Sehgal, B J Allison, S M Gwini, S Menahem, S L Miller, G R Polglase
OBJECTIVE: To assess arterial morphology and mechanics in preterm infants with fetal growth restriction (FGR) compared with those appropriate for gestational age (AGA) in the early neonatal period. STUDY DESIGN: This observational study involved 20 preterm FGR infants (28 to 32 weeks) of gestational age (GA) and birth weight (BW) <10th centile and 20 preterm AGA infants. Vascular ultrasound was performed to measure aortic properties. RESULTS: GA and BW of FGR and AGA infants were 29...
November 9, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29098123/point-of-care-ultrasound-diagnosis-of-a-massive-thoracoabdominal-aortic-aneurysm
#4
Allison M Yee, Cyrus V Etebari, Srikar Adhikari, Richard Amini
This report highlights an atypical presentation of extensive thoracoabdominal aortic aneurysm with intramural hematoma and transient paralysis of the lower extremities. Clinical suspicion for aortic pathology prompted a point of care ultrasound of the heart and aorta, which demonstrated a thoracic and abdominal aortic aneurysm with intraluminal pathology. Consultation and transfer to a tertiary care facility was based solely on the emergency physician's ultrasound. Subsequent computed tomography (CT) imaging confirmed the ultrasound findings and discovered a left common iliac artery thrombosis consistent with the patient's presentation...
August 26, 2017: Curēus
https://www.readbyqxmd.com/read/29079007/ten-year-outcome-analysis-of-the-italian-excluder-registry-with-the-gore-excluder-endograft-for-infrarenal-abdominal-aortic-aneurysms
#5
Giovanni Pratesi, Gabriele Piffaretti, Fabio Verzini, Giovanni De Blasis, Patrizio Castelli, Carlo Pratesi
OBJECTIVE: The objective of this study was to report the 10-year outcomes of the multicenter Italian Excluder Registry for elective endovascular aneurysm repair (EVAR). METHODS: A retrospective analysis of all patients who underwent elective EVAR using the Gore Excluder (W. L. Gore & Associates, Flagstaff, Ariz) endograft (EG) at four Italian centers between 1998 and 2006 was carried out. Follow-up consisted of duplex ultrasound scan and computed tomography performed at 1 month, 6 months, and 12 months and yearly thereafter...
October 24, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29066079/diagnosis-of-aortic-dissection-presenting-as-st-elevation-myocardial-infarction-using-point-of-care-ultrasound
#6
Jordan Chenkin
BACKGROUND: Aortic dissections can present with a broad spectrum of signs and symptoms, making them difficult to diagnose in the emergency department (ED). Aortic dissections can cause occlusion of the coronary arteries, mimicking an acute ST-elevation myocardial infarction (STEMI). Emergency point-of-care ultrasound (POCUS) may be a useful diagnostic tool to help differentiate aortic dissection from a primary myocardial infarction. CASE REPORT: A 69-year-old man with no medical history presented to our ED complaining of chest pain...
October 20, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29053103/ultrasound-functional-imaging-in-an-i-ex-vivo-i-beating-porcine-heart-platform
#7
Niels J Petterson, Louis S Fixsen, Marcel C M Rutten, Nico H J Pijls, Frans N van de Vosse, Richard G P Lopata
In recent years, novel ultrasound functional imaging (UFI) techniques have been introduced to assess cardiac function by measuring, e.g., cardiac output (CO) and/or myocardial strain. Verification and reproducibility assessment in a realistic setting remain major issues. Simulations and phantoms are often unrealistic, whereas in vivo measurements often lack crucial hemodynamic parameters or ground truth data, or suffer from the large physiological and clinical variation between patients when attempting clinical validation...
October 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29051395/role-of-computer-tomography-and-endoscopic-ultrasonography-in-assessing-portal-and-superior-mesenteric-vessels-invasion-in-cephalo-pancreatic-adenocarcinoma
#8
Raluca Bodea, Andrada Seicean, Tudor Vasile, Tudor Calinici, Irina Ciuca, Nadim Al Hajjar, Cornel Iancu, Constantin Iordache
AIM: The aim of this study is to evaluate the information given by contrast-enhanced computer tomography (CECT) and ultrasound endoscopy (EUS) regarding vascular involvement of cephalo-pancreatic cancer, data compared with intraoperative findings. MATERIAL AND METHODS: We choose to analyze the most often interested vessels by tumor development, such as superior mesenteric artery (SMA), superior mesenteric vein (SMV) and portal vein (PV). The patients included in the study (n=425) had a cephalo-pancreatic tumor diagnosed in our Institute and a positive histology for pancreatic adenocarcinoma...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28989555/noninvasive-evaluation-of-varying-pulse-pressures-in-vivo-using-brachial-sphymomanometry-applanation-tonometry-and-pulse-wave-ultrasound-manometry
#9
Ronny X Li, Ada Ip, Elena Sanz-Miralles, Elisa E Konofagou
The routine assessment and monitoring of hypertension may benefit from the evaluation of arterial pulse pressure (PP) at more central locations (e.g. the aorta) rather solely at the brachial artery. Pulse Wave Ultrasound Manometry (PWUM) was previously developed by our group to provide direct, noninvasive aortic PP measurements using ultrasound elasticity imaging. Using PWUM, radial applanation tonometry, and brachial sphygmomanometry, this study investigated the feasibility of noninvasively obtaining direct PP measurements at multiple arterial locations in normotensive, pre-hypertensive, and hypertensive human subjects...
June 2017: Artery Research
https://www.readbyqxmd.com/read/28983674/contrast-enhanced-ultrasound-ceus-of-the-abdominal-vasculature
#10
REVIEW
Vasileios Rafailidis, Cheng Fang, Gibran T Yusuf, Dean Y Huang, Paul S Sidhu
Vascular diseases account for a significant proportion of abdominal pathology and represent a common referral source for abdominal ultrasonographic examinations. B-mode, color Doppler, and spectral Doppler analyses are well-established in the evaluation of abdominal blood vessels although they may occasionally be limited by lower sensitivity for slow flow visualization or the deeper location of abdominal vascular structures. The introduction of microbubbles as ultrasonographic contrast agents has rendered contrast-enhanced ultrasound (CEUS), a valuable complementary ultrasonographic technique, which is capable of addressing clinically significant problems and guiding patient management...
October 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28982198/monitoring-inflammation-injuries-in-the-progression-of-atherosclerosis-with-contrast-enhanced-ultrasound-molecular-imaging
#11
Ruiying Sun, Jie Tian, Jun Zhang, Liping Wang, Jing Guo, Yani Liu
PURPOSE: The upregulation of vascular cell adhesion molecule-1(VCAM-1) on vascular endothelium plays a great role in the progression of atherosclerosis (AS). In this study, ultrasound molecular imaging was performed to monitor the inflammation injuries in the onset and progression of atherosclerosis with microbubbles targeted to VCAM-1. METHODS: Mice deficient for the apolipoprotein E (ApoE-/-mice) with high-cholesterol diet were studied as an age-dependent model of atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28974566/cardiovascular-structure-and-function-in-children-with-middle-aortic-syndrome-and-renal-artery-stenosis
#12
Rawan K Rumman, Cameron Slorach, Wei Hui, Mina Matsuda-Abedini, Valerie Langlois, Seetha Radhakrishnan, Armando J Lorenzo, Joao Amaral, Luc Mertens, Rulan S Parekh
Middle aortic syndrome (MAS) is a narrowing of the abdominal aorta, often in conjunction with renal artery stenosis (RAS). Structure and function of the cardiovascular system are not well understood. In a prospective cross-sectional study, 35 children with MAS or RAS or both (MAS/RAS) were compared with 140 age-, sex-, and body surface area-matched healthy children. Vascular assessment included carotid intima-media thickness and carotid distensibility using B-mode ultrasound and central and peripheral pulse wave velocities using applanation tonometry...
October 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28970802/characteristics-of-carotid-artery-structure-and-mechanical-function-and-their-relationships-with-aortopathy-in-patients-with-bicuspid-aortic-valves
#13
Mihyun Kim, Chi Young Shim, Seong-Chan You, In-Jeong Cho, Geu-Ru Hong, Jong-Won Ha, Namsik Chung
Patients with a bicuspid aortic valve (BAV) often have proximal aortic dilatation and systemic vascular dysfunction. We hypothesized that BAV patients would have different carotid artery structural and functional characteristics compared to tricuspid aortic valve (TAV) patients. In 28 patients with surgically confirmed BAV and 27 patients with TAV, intima media thickness (IMT), number of plaques, fractional area change (FAC), global circumferential strain (GCS), and standard deviation of CS (SD-CS) in both common carotid arteries were assessed using duplex ultrasound and velocity vector imaging (VVI)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28960319/sonographic-assessment-of-volaemia-development-and-validation-of-a-new-method-in-dogs
#14
M Cambournac, I Goy-Thollot, A Violé, C Boisvineau, C Pouzot-Nevoret, A Barthélemy
OBJECTIVES: The aims of this study were to describe a method for the sonographic assessment of volaemia, to determinate inter- and intra-operator variability and to assess the ability to detect blood loss after blood donation in healthy dogs. MATERIALS AND METHODS: The left kidney was identified in a spleno-renal view, and transverse views of the caudal vena cava and aorta were obtained in 12 dogs. Vessel diameters were measured in B-mode, in duplicate by two operators, and the caudal vena cava:aorta ratio was calculated...
September 27, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28930095/robust-and-practical-non-invasive-estimation-of-local-arterial-wave-speed-and-mean-blood-velocity-waveforms
#15
Remi Kowalski, Richard Beare, Marie Willemet, Jordi Alastruey, Joseph J Smolich, Michael M H Cheung, Jonathan P Mynard
OBJECTIVE: Local arterial wave speed, a surrogate of vessel stiffness, can be estimated via the pressure-velocity (PU) and diameter-velocity (ln(D)U) loop methods. These assume negligible early-systolic reflected waves (RWes) and require measurement of cross-sectionally averaged velocity (U mean), which is related to volumetric blood flow. However, RWes may not always be negligible and Doppler ultrasound typically provides maximum velocity waveforms or estimates of mean velocity subject to various errors (U raw)...
November 1, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28927895/adherence-to-a-mediterranean-diet-is-associated-with-the-presence-and-extension-of-atherosclerotic-plaques-in-middle-aged-asymptomatic-adults-the-aragon-workers-health-study
#16
Rocío Mateo-Gallego, Irina Uzhova, Belén Moreno-Franco, Montserrat León-Latre, José A Casasnovas, Martín Laclaustra, José L Peñalvo, Fernando Civeira
BACKGROUND: The Mediterranean diet (MeDi) is known to prevent cardiovascular events but the mechanisms mediating this association are not fully understood. OBJECTIVE: The objective of the study was to examine the association between MeDi adherence and the presence and extent of atherosclerotic plaques in carotid, femoral, and aorta territories and its relationship with risk factors in asymptomatic middle-aged adults. METHODS: Cross-sectional analysis of the Aragon Workers' Health Study, a cohort of 2588 subjects (94...
August 24, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28904928/prenatal-sonographic-diagnosis-of-hypoplastic-left-heart-syndrome
#17
Raghu Teja Sadineni, B Santh Kumar, N B Chander, Durga Mahita Boppana
Hypoplastic left heart syndrome (HLHS) represents a variety of cardiac malformations that may result from errors in the early stages of cardiac development. HLHS includes a wide spectrum of cardiac malformations including hypoplasia of the left ventricle, ascending aorta, hypoplasia, or atresia of the aortic and mitral valves. Over the recent years, the improved resolution of advanced equipment with awareness and increased performance of second-trimester ultrasound examinations for the assessment of fetal anomalies have helped in understanding the spectrum and have expanded our knowledge of HLHS...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28893830/assessment-of-paravalvular-leakage-after-transcatheter-aortic-valve-implantation-add-clinical-signs-to-echocardiographic-data
#18
Corstiaan A den Uil, Mihai Strachinaru, Ben van der Hoven, J Han J Meeder
A 62-year old male with pulmonary fibrosis and aortic valve stenosis underwent TAVI (Corevalve Evolut XL 34 mm) in the build-up for lung transplantation (LuTx). Following post-dilation for a large annular perimeter, moderate paravalvular aortic regurgitation (AR) was observed. After 6 weeks, he was admitted to the ICU with respiratory failure(A). TTE demonstrated residual mild AR (based on a small excentric paravalvular AR jet, <10% circumferential extent, pressure half-time was not reliably measured) and together with borderline elevated NT-pro-BNP, the consultant cardiologist authorized LuTx listing...
September 11, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28890304/hemodynamic-parameters-that-may-predict-false-lumen-growth-in-type-b-aortic-dissection-after-endovascular-repair-a-preliminary-study-on-long-term-multiple-follow-ups
#19
Huanming Xu, Zhenfeng Li, Huiwu Dong, Yilun Zhang, Jianyong Wei, Paul N Watton, Wei Guo, Duanduan Chen, Jiang Xiong
Thoracic endovascular aortic repair (TEVAR) is commonly applied in type-B aortic dissection. For patients with dissection affects descending aorta and extends downward to involve abdominal aorta and possibly iliac arteries, false lumen (FL) expansion might occur post-TEVAR. Predictions of dissection development may assist in medical decision on re-intervention or surgery. In this study, two patients are selected with similar morphological features at initial presentation but with different long-term FL development post-TEVAR (stable and enlarged FL)...
December 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28883542/longitudinal-micro-ultrasound-assessment-of-the-ob-ob-mouse-model-evaluation-of-cardiovascular-renal-and-hepatic-parameters
#20
N Di Lascio, C Kusmic, F Stea, F Lenzarini, C Barsanti, A Leloup, F Faita
BACKGROUND/OBJECTIVES: Obesity is reaching epidemic proportions and is associated with increased risk factors for cardiovascular disease (CVD). Leptin-deficient mice (ob/ob) are widely employed to investigate obesity. Aim of this study was to provide a micro-ultrasound (μUS) longitudinal evaluation of the ob/ob mouse model in terms of cardiovascular effects, consequences for renal microcirculation and liver fat accumulation. SUBJECTS/METHODS: Sixteen wild-type (wt) and eleven ob/ob male mice were studied at 8 (T0) and 25 (T1) weeks of age with a μUS system (Vevo2100) and B-mode and Doppler images were acquired...
September 8, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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