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https://www.readbyqxmd.com/read/29559813/ocular-surface-squamous-neoplasia-in-hiv-infected-patients-current-perspectives
#1
REVIEW
Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki
Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure...
2018: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/29511061/population-based-incidence-of-conjunctival-tumours-in-olmsted-county-minnesota
#2
Lauren A Dalvin, Diva R Salomão, Sanjay V Patel
AIM: To determine population-based incidence of conjunctival tumours in Olmsted County, Minnesota. METHODS: The Rochester Epidemiology Project medical record linkage system was used to identify patients with conjunctival tumours in Olmsted County (1 January 1980 to 31 December 2015). Records were reviewed for demographics, types of tumours, histopathology, treatment and clinical course. Incidence rate of all tumours was calculated per 1 000 000 person-years. Poisson regression analysis was used to assess changes in incidence over time...
March 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29511060/p16-ink4a-overexpression-as-a-predictor-of-survival-in-ocular-surface-squamous-neoplasia
#3
Sheetal Chauhan, Seema Sen, Anjana Sharma, Seema Kashyap, Radhika Tandon, Mandeep S Bajaj, Neelam Pushker, Murugesan Vanathi, Shyam S Chauhan
AIMS: To evaluate the expression and methylation status of the p16INK4a gene in early and advanced American Joint Committee on Cancer (AJCC) stages of ocular surface squamous neoplasia (OSSN) and to correlate its association with clinicopathological features and survival. METHODS: Sixty-four (35 early and 29 advanced AJCC stage) patients with OSSN formed part of this study and were followed up for 36-58 (mean 48±3.6) months. Immunohistochemical expression of the p16INK4a protein and methylation status of the p16INK4a gene were determined by methylation-specific PCR...
March 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29423784/ocular-surface-squamous-neoplasia-in-a-setting-of-fungal-keratitis-a-rare-co-occurrence
#4
Swati Singh, Ruchi Mittal, Purvasha Narang, Vikas Mittal
PURPOSE: To describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis. METHODS: Case report. RESULTS: We describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven severe fungal keratitis of 5 months duration, which progressed to endophthalmitis. She was managed with extended enucleation for left eye. Histopathology examination was consistent with squamous cell carcinoma of ocular surface with no corneal stromal/scleral/anterior chamber involvement...
February 8, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29376005/amniotic-membrane-transplantation-with-topical-interferon-alfa-2b-after-excision-of-ocular-surface-squamous-neoplasia
#5
Hua-Tao Xie, Ying-Ying Zhang, Dong-Ling Jiang, Jun Wu, Jia-Song Wang, Ming-Chang Zhang
To evaluate the outcome of amniotic membrane transplantation (AMT) after tumor excision followed by topical interferon alfa-2b (IFNα2b) drops for primary ocular surface squamous neoplasia (OSSN). Twelve eyes of 12 patients with a mean age of 66±10y were included. The average follow-up was 23±10mo. All 12 patients had limbal involvement. Smooth ocular surface and transparent cornea were achieved in all cases. No sign of inflammation, neovascularization, symblepharon or recurrence was noted at the last follow-up...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29362973/role-of-topical-interferon-alpha-2b-in-mitomycin-c-resistant-ocular-surface-squamous-neoplasia-our-preliminary-findings
#6
Manpreet Singh, Natasha Gautam, Manpreet Kaur
PURPOSE: To report the clinical presentation of mitomycin-C (MMC)-resistant ocular surface squamous neoplasia (OSSN) and its treatment outcome with topical interferon alpha-2b (IFNα-2b). METHODS: A prospective, non-randomised, pilot study enrolling clinically diagnosed OSSN patients. The inclusion criterion was resistance of OSSN to standard topical MMC (0.02%) chemotherapy. The resistance was defined as 'no clinical response' in the terms of reduction in tumour size, extension and vascularity after minimum 6 weeks 'on-cycles' of MMC...
January 23, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29306088/changes-in-in-vivo-confocal-microscopic-findings-of-ocular-surface-squamous-neoplasia-during-treatment-with-topical-interferon-alfa-2b
#7
Mehran Zarei-Ghanavati, Ebrahim Mousavi, Amin Nabavi, Golshan Latifi, Hadi Z Mehrjardi, Masoomeh Mohebbi, Hamed Ghassemi, Farrin Mirzaie, Mohammad Ali Zare
PURPOSE: To evaluate in vivo confocal microscopy (IVCM) findings of ocular surface squamous neoplasia (OSSN) during treatment with topical interferon alfa-2b (IFN alfa-2b). METHODS: In this prospective interventional case series, 20 eyes from 20 patients with OSSN were treated with topical IFN alfa-2b 3 million IU/mL four times a day. Treatment was continued for 2 or 3 months after clinical resolution. IVCM was done at baseline, on a monthly basis, and at the end of treatment...
April 2018: Ocular Surface
https://www.readbyqxmd.com/read/29283124/topical-chemotherapy-for-giant-ocular-surface-squamous-neoplasia-of-the-conjunctiva-and-cornea-is-surgery-necessary
#8
Sonal S Chaugule, Jennifer Park, Paul T Finger
PURPOSE: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN). METHODS: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29197837/bilateral-ocular-surface-squamous-neoplasia-with-bilateral-periocular-basal-cell-carcinoma-in-a-case-of-xeroderma-pigmentosum
#9
Rohit Agarwal, Bhavna Chawla, Mohamed Ibrahime Asif, Amar Pujari
Xeroderma pigmentosum (XP) is an autosomal recessive disorder associated with multiple oculocutaneous manifestations.We discuss a unique case of XP having bilateral ocular surface squamous neoplasia (OSSN) and periocular basal cell carcinoma. In the right eye, a large OSSN mass involving the ocular surface extensively along with intraocular invasion was noted, whereas in the left eye, the tumour mass was involving the limbus, and extending up to three clock hours. Because of extensive disease in the right eye, orbital exenteration was performed, and for the left eye, a wide excision of the mass with triple freeze thaw cryo application to the margins followed by amniotic membrane grafting was done...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29190165/challenging-treatment-of-ocular-surface-squamous-neoplasia-in-patients-with-atopic-disease
#10
Lily Zhang, Carolina Mercado, Anat Galor, Edward J Holland, Gaofeng Wang, Carol L Karp
PURPOSE: Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN. METHODS: Retrospective case series. RESULTS: Three male patients with mean age of 73 presented with OSSN and history of atopy treated with immunosuppressant therapy. Their histories included atopic dermatitis and keratoconjunctivitis...
November 30, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29044057/clinicodemographic-profile-and-treatment-outcome-in-patients-of-ocular-surface-squamous-neoplasia
#11
Rachna Meel, Rebika Dhiman, Murugesan Vanathi, Neelam Pushker, Radhika Tandon, Saranya Devi
PURPOSE: The aim is to study the clinicodemographic profile and treatment outcome of ocular surface squamous neoplasia (OSSN). METHODS: This was a retrospective observational study of 57 eyes (56 cases) with clinically diagnosed OSSN, presenting in our center over the past year. RESULTS: The median age of presentation was 55 years with male:female ratio being 4.5:1. Systemic predisposing conditions were xeroderma pigmentosa (1) postkidney transplant immunosuppression (1), and human immunodeficiency virus infection (1)...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28967069/mitomycin-c-or-interferon-as-adjuvant-therapy-to-surgery-for-ocular-surface-squamous-neoplasia-comparative-study
#12
Maria Antonietta Blasi, Martina Maceroni, Maria Grazia Sammarco, Monica M Pagliara
BACKGROUND: Traditionally, surgical excision has been the treatment of choice for ocular surface squamous neoplasia (OSSN). Recurrences after surgery are high. To reduce the risk of recurrence, adjuvant therapies have been increasingly used. PURPOSE: We compared recurrences and complications of 3 forms of treatment for OSSN: surgical excision (group A), surgical excision plus adjuvant topical mitomycin C (MMC) (group B), and surgical excision plus subconjunctival interferon-α-2b (IFN-α-2b) (group C)...
September 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28937145/immunoreduction-of-ocular-surface-tumours-with-intralesional-interferon-alpha-2a
#13
S E Kim, S M Salvi
PurposeTo share our initial experience in the use of intralesional interferon alpha-2a at primary presentation in ocular surface tumours as a method of immunoreduction prior to definitive surgical management.MethodsCase series of patients referred to Sheffield Ocular Oncology Service with rapidly growing ocular surface tumours, treated with intralesional interferon alpha-2a at first presentation prior to definitive surgical management.ResultsAll three patients, two with conjunctival melanoma and one with ocular surface squamous neoplasia (OSSN) demonstrated immunoreduction of tumour without any adverse side effects...
September 22, 2017: Eye
https://www.readbyqxmd.com/read/28705204/delay-along-the-care-seeking-journey-of-patients-with-ocular-surface-squamous-neoplasia-in-kenya
#14
Stephen Gichuhi, Joy Kabiru, Alain M'bongo Zindamoyen, Hillary Rono, Ernest Ollando, Joseph Wachira, Rhoda Munene, Timothy Onyuma, Mandeep S Sagoo, David Macleod, Helen A Weiss, Matthew J Burton
BACKGROUND: In Africa, accessing eye health services is a major challenge. Ocular surface squamous neoplasia (OSSN) is a substantial ocular health problem in Africa related to solar UV light exposure and HIV infection among other risk factors. The disease causes visual loss and even death in advanced cases. This study was conducted to assess referral pathway and treatment delay for patients with OSSN in Kenya. METHODS: Adults with conjunctival lesions presenting to four eye centres were asked about their occupations, when they noticed the growth, health facilities visited in seeking care, cost of consultation, surgery, medicines and histopathology and dates at each step...
July 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28591290/adjuvant-treatment-or-primary-topical-monotherapy-for-ocular-surface-squamous-neoplasia-a-systematic-review
#15
REVIEW
Gustavo Arruda Viani, Ligia Issa de Fendi
In this systematic review, we evaluated studies involving adjuvant and primary topical treatment for ocular surface squamous neoplasia (OSSN). The findings were: (i) adjuvant 5-fluorouracil (5-FU) reduces the risk of relapse after surgical excision with mild side effects [level Ib, grade of recommendation (GR) A]. (ii) Primary topical mitomycin (MMC) produces a high rate of complete response, low recurrence rate, and mild side effects (level Ib, GR A). (iii) Primary chemotherapy versus adjuvant chemotherapy produce similar rates of recurrence, with no significant difference (level IIb, GR B)...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28557835/giant-ocular-surface-squamous-neoplasia-wrapping-whole-cornea
#16
Dhivya Ashok Kumar, Amar Agarwal
We present a giant ocular surface squamous neoplasia (OSSN) measuring approximately 20×18 mm arising from the fornix and wrapping the entire 12 clock hours of the cornea. The surgical excision was performed with preservation of the corneal surface. A 3-mm clear margin was obtained all around the mass. The histopathology confirmed as moderately differentiated squamous cell carcinoma with clear margins. The postoperative period was uneventful, and a clear cornea without a residual scar with best corrected visual acuity of 20/20 was attained...
May 26, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28399347/conjunctival-tumors-review-of-clinical-features-risks-biomarkers-and-outcomes-the-2017-j-donald-m-gass-lecture
#17
Carol L Shields, Jason L Chien, Thamolwan Surakiatchanukul, Kareem Sioufi, Sara E Lally, Jerry A Shields
Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Regarding OSSN, pre-disposing conditions include chronic solar radiation, immune deficiency (HIV), organ transplant, autoimmune conditions, xeroderma pigmentosum, and chronic exposure to cigarette smoke. OSSN is managed surgically or with topical/injection immunotherapy or chemotherapy...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28350623/ocular-surface-squamous-neoplasia-in-papillon-lef%C3%A3-vre-syndrome-outcome-at-long-term-follow-up-of-12-years
#18
Swathi Kaliki, Swati Singh, Swarnalata Gowrishankar, Vijay Anand P Reddy
PURPOSE: To discuss the association between ocular surface squamous neoplasia (OSSN) and Papillon-Lefèvre syndrome (PLS) and present the long-term outcome in a patient with these diseases. METHODS: Case report. RESULTS: A 14-year-old boy presented with a raised pigmented mass lesion at the limbus in the right eye, which was clinically suggestive of OSSN. He also had palmoplantar hyperkeratosis and periodontosis suggestive of PLS. Excision biopsy of the lesion confirmed the diagnosis of OSSN...
June 2017: Cornea
https://www.readbyqxmd.com/read/28347855/role-of-high-resolution-optical-coherence-tomography-in-diagnosing-ocular-surface-squamous-neoplasia-with-coexisting-ocular-surface-diseases
#19
Marwan Atallah, Madhura Joag, Anat Galor, Guillermo Amescua, Afshan Nanji, Jianhua Wang, Victor L Perez, Sander Dubovy, Carol L Karp
PURPOSE: Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and differentiation of OSSN within coexisting ocular surface pathologies. METHODS: Retrospective study of 16 patients with ocular surface disease and lesions suspicious for OSSN that were evaluated with HR-OCT. HR-OCT images of the lesions were taken to look for evidence of OSSN...
October 2017: Ocular Surface
https://www.readbyqxmd.com/read/28275607/intracorneal-and-intraocular-invasion-of-ocular-surface-squamous-neoplasia-after-intraocular-surgery-report-of-two-cases-and-review-of-the-literature
#20
Juan C Murillo, Anat Galor, Michael C Wu, Natasha K Kye, James Wong, Ibrahim O Ahmed, Madhura Joag, Nabeel Shalabi, William Lahners, Sander Dubovy, Carol L Karp
PURPOSE: The aim of this paper was to describe 2 cases of ocular surface squamous neoplasia (OSSN) of the conjunctiva with intracorneal and intraocular extension following intraocular surgery. METHODS: We conducted a clinical pathological retrospective case series. RESULTS: Case 1 underwent cataract surgery in the setting of an unnoticed adjacent OSSN. An excisional biopsy with cryotherapy and intraoperative mitomycin C was subsequently performed, confirming OSSN...
January 2017: Ocular Oncology and Pathology
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