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https://www.readbyqxmd.com/read/28591290/adjuvant-treatment-or-primary-topical-monotherapy-for-ocular-surface-squamous-neoplasia-a-systematic-review
#1
Gustavo Arruda Viani, Ligia Issa de Fendi
In this systematic review, we evaluated studies involving adjuvant and primary topical treatment for ocular surface squamous neoplasia (OSSN). The findings were: (i) adjuvant 5-fluorouracil (5-FU) reduces the risk of relapse after surgical excision with mild side effects [level Ib, grade of recommendation (GR) A]. (ii) Primary topical mitomycin (MMC) produces a high rate of complete response, low recurrence rate, and mild side effects (level Ib, GR A). (iii) Primary chemotherapy versus adjuvant chemotherapy produce similar rates of recurrence, with no significant difference (level IIb, GR B)...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28557835/giant-ocular-surface-squamous-neoplasia-wrapping-whole-cornea
#2
Dhivya Ashok Kumar, Amar Agarwal
We present a giant ocular surface squamous neoplasia (OSSN) measuring approximately 20×18 mm arising from the fornix and wrapping the entire 12 clock hours of the cornea. The surgical excision was performed with preservation of the corneal surface. A 3-mm clear margin was obtained all around the mass. The histopathology confirmed as moderately differentiated squamous cell carcinoma with clear margins. The postoperative period was uneventful, and a clear cornea without a residual scar with best corrected visual acuity of 20/20 was attained...
May 26, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28399347/conjunctival-tumors-review-of-clinical-features-risks-biomarkers-and-outcomes-the-2017-j-donald-m-gass-lecture
#3
Carol L Shields, Jason L Chien, Thamolwan Surakiatchanukul, Kareem Sioufi, Sara E Lally, Jerry A Shields
Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Regarding OSSN, pre-disposing conditions include chronic solar radiation, immune deficiency (HIV), organ transplant, autoimmune conditions, xeroderma pigmentosum, and chronic exposure to cigarette smoke. OSSN is managed surgically or with topical/injection immunotherapy or chemotherapy...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28350623/ocular-surface-squamous-neoplasia-in-papillon-lef%C3%A3-vre-syndrome-outcome-at-long-term-follow-up-of-12-years
#4
Swathi Kaliki, Swati Singh, Swarnalata Gowrishankar, Vijay Anand P Reddy
PURPOSE: To discuss the association between ocular surface squamous neoplasia (OSSN) and Papillon-Lefèvre syndrome (PLS) and present the long-term outcome in a patient with these diseases. METHODS: Case report. RESULTS: A 14-year-old boy presented with a raised pigmented mass lesion at the limbus in the right eye, which was clinically suggestive of OSSN. He also had palmoplantar hyperkeratosis and periodontosis suggestive of PLS. Excision biopsy of the lesion confirmed the diagnosis of OSSN...
June 2017: Cornea
https://www.readbyqxmd.com/read/28347855/role-of-high-resolution-optical-coherence-tomography-in-diagnosing-ocular-surface-squamous-neoplasia-with-coexisting-ocular-surface-diseases
#5
Marwan Atallah, Madhura Joag, Anat Galor, Guillermo Amescua, Afshan Nanji, Jianhua Wang, Victor L Perez, Sander Dubovy, Carol L Karp
PURPOSE: Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and differentiation of OSSN within coexisting ocular surface pathologies. METHODS: Retrospective study of 16 patients with ocular surface disease and lesions suspicious for OSSN that were evaluated with HR-OCT. HR-OCT images of the lesions were taken to look for evidence of OSSN...
March 24, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28275607/intracorneal-and-intraocular-invasion-of-ocular-surface-squamous-neoplasia-after-intraocular-surgery-report-of-two-cases-and-review-of-the-literature
#6
Juan C Murillo, Anat Galor, Michael C Wu, Natasha K Kye, James Wong, Ibrahim O Ahmed, Madhura Joag, Nabeel Shalabi, William Lahners, Sander Dubovy, Carol L Karp
PURPOSE: The aim of this paper was to describe 2 cases of ocular surface squamous neoplasia (OSSN) of the conjunctiva with intracorneal and intraocular extension following intraocular surgery. METHODS: We conducted a clinical pathological retrospective case series. RESULTS: Case 1 underwent cataract surgery in the setting of an unnoticed adjacent OSSN. An excisional biopsy with cryotherapy and intraoperative mitomycin C was subsequently performed, confirming OSSN...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28275599/ocular-surface-squamous-neoplasia-associated-with-atopic-keratoconjunctivitis
#7
Ankit Shah, Edgar M Espana, Arun D Singh
PURPOSE: To describe 2 cases of invasive squamous cell carcinoma that originated in the setting of severe atopic keratoconjunctivitis (AKC). METHODS: Case one involved a 73-year-old male with atopic eczema and severe AKC who developed a limbal lesion suspicious for ocular surface squamous neoplasia (OSSN). Slit-lamp examination was significant for a new sessile lesion in the temporal limbal region of the left eye. The lesion was treated with excisional biopsy and cryotherapy...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28184236/diagnosis-and-medical-management-of-ocular-surface-squamous-neoplasia
#8
Ibrahim O Sayed-Ahmed, Sotiria Palioura, Anat Galor, Carol L Karp
INTRODUCTION: Topical chemotherapy has gained popularity among clinicians for the treatment of ocular surface squamous neoplasia (OSSN). The principal topical chemotherapy agents used in the management of OSSN are interferon-α2b, 5-fluorouracil, and mitomycin C. High-resolution optical coherence tomography (HR-OCT) is a non-invasive technique that can differentiate OSSN from other ocular surface lesions. AREAS COVERED: This review highlights the current regimens and diagnostic modalities used in managing OSSN...
2017: Expert Review of Ophthalmology
https://www.readbyqxmd.com/read/28129301/immunosuppression-as-a-possible-risk-factor-for-interferon-nonresponse-in-ocular-surface-squamous-neoplasia
#9
Noy Ashkenazy, Carol L Karp, Gaofeng Wang, Carolina Mercado Acosta, Anat Galor
PURPOSE: The mechanism by which ocular surface squamous neoplasia (OSSN) responds to topical interferon-alpha-2b (IFNα2b) is not known. We report the cases of 3 immunosuppressed patients whose tumors did not respond to topical IFNα2b therapy. The purpose of this series is to shed light on potential mechanisms of IFNα2b in OSSN. METHODS: Retrospective case series of 3 immunosuppressed patients whose biopsy-proven OSSN did not respond to topical IFNα2b treatment...
April 2017: Cornea
https://www.readbyqxmd.com/read/28129293/ocular-surface-epithelial-atypia-mimicking-squamous-neoplasia-in-association-with-ulcerative-colitis
#10
Sally S Ong, Scott D Walter, Xi Chen, Gargi K Vora, Melissa Daluvoy, Alan D Proia, Prithvi Mruthyunjaya
PURPOSE: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). METHODS: Case report. RESULTS: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/27994810/prevalence-and-severity-of-ocular-surface-neoplasia-in-african-nations-and-need-for-early-interventions
#11
REVIEW
Jacob W Reynolds, Margaret L Pfeiffer, Omar Ozgur, Bita Esmaeli
Ocular surface squamous neoplasia (OSSN) is a common ocular surface tumor with an increased incidence in African countries (3.4 and 3.0 cases/year/100,000). Despite its potential for vision loss and death, OSSN remains largely neglected by both eye and HIV care programs in Africa. The purpose of this review is to identify the barriers to timely diagnosis and early interventions for OSSN in Africa. PubMed searches were conducted targeting previous use of topical chemotherapy (interferon alpha 2b, Mitomycin-C, 5-Fluorouracil) and Human papillomavirus (HPV) vaccination in Africa...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27941046/topical-1-5-fluoruracil-as-a-sole-treatment-of-corneoconjunctival-ocular-surface-squamous-neoplasia-long-term-study
#12
Raffaele Parrozzani, Luisa Frizziero, Sara Trainiti, Ilaria Testi, Giacomo Miglionico, Elisabetta Pilotto, Stella Blandamura, Ambrogio Fassina, Edoardo Midena
AIMS: To report long-term clinical outcome of topical 1% 5-fluoruracil (5-FU) as a sole treatment of ocular surface squamous neoplasia (OSSN). METHODS: 41 patients affected by OSSN were included. Each patient underwent full ophthalmological examination at baseline, with cytological or histological confirmation. Patients were treated by topical chemotherapy with 1% 5-FU four times a day for 4 weeks. One course was defined as 4 weeks of topical chemotherapy. Adjunctive courses were administered after 1 month of chemotherapy-free interval...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27935054/damaging-effects-of-ultraviolet-radiation-on-the-cornea
#13
Naomi C Delic, J Guy Lyons, Nick Di Girolamo, Gary M Halliday
The cornea sits at the anterior aspect of the eye and additionally to the skin, is highly exposed to ultraviolet radiation (UVR). The cornea blocks a significant proportion of UVB from reaching the posterior structures of the eye. However, UVA can penetrate the full thickness of the cornea, even reaching the anterior portion of the lens. Epidemiological data indicate that UVR is a contributing factor for a multitude of corneal diseases of the cornea including pterygium, photokeratitis, climatic droplet keratopathy, (CDK) and ocular surface squamous neoplasia (OSSN), although the pathogenic mechanisms of each require further elucidation...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27905329/recombinant-interferon-alpha-2b-for-ocular-surface-squamous-neoplasia-an-efficient-and-cost-effective-treatment-modality-in-asian-indian-patients
#14
Swathi Kaliki, Swati Singh, Sadiya Iram, Dharani Tripuraneni
PURPOSE: The purpose was to study the efficacy of interferon alpha 2b (INF α2b) in the treatment of ocular surface squamous neoplasia (OSSN) and analyze its cost-effectiveness in India. STUDY DESIGN: This was a retrospective study of thirty patients with OSSN treated with topical INF α2b (1 MIU/cc) ± perilesional INF α2b (5 MIU/cc). RESULTS: The tumor involved cornea (n = 9, 30%), conjunctivo-limbal-corneal surface (n = 19, 63%), or bulbar conjunctiva (n = 2, 7%)...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27832940/concomitant-simple-limbal-epithelial-transplantation-after-surgical-excision-of-ocular-surface-squamous-neoplasia
#15
COMPARATIVE STUDY
Swathi Kaliki, Faraz Ali Mohammad, Prerana Tahiliani, Virender S Sangwan
PURPOSE: To compare the surgical outcomes of ocular surface squamous neoplasia (OSSN) following wide excisional biopsy with and without primary simple limbal epithelial transplantation (p-SLET). DESIGN: Nonrandomized clinical study with historical controls. METHODS: setting: Single-institutional study. PATIENTS: Eight patients who underwent wide excisional biopsy of OSSN without p-SLET (historical controls) and 7 patients with p-SLET (cases)...
February 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27826936/ocular-surface-squamous-neoplasia-as-the-initial-presenting-sign-of-human-immunodeficiency-virus-infection-in-60-asian-indian-patients
#16
Swathi Kaliki, Saurabh Kamal, Saba Fatima
PURPOSE: To study the importance of routine human immunodeficiency virus (HIV) screening in patients with ocular surface squamous neoplasia (OSSN) and describe their clinical features and management. METHODS: Retrospective study. RESULTS: Of 228 cases of OSSN screened for HIV by enzyme-linked immunosorbent assay, 86 (38%) patients were HIV positive. Of these 86 patients, 60 (70%) were unaware of their HIV-positive status prior to HIV screening...
November 8, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27800176/anterior-segment-imaging-in-ocular-surface-squamous-neoplasia
#17
REVIEW
Sally S Ong, Gargi K Vora, Preeya K Gupta
Recent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN) is diagnosed and monitored. Ultrasound biomicroscopy (UBM) has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVCM) shows enlarged and irregular nuclei with hyperreflective cells in OSSN lesions and this has been found to correlate with histopathology findings. Anterior segment optical coherence tomography (AS-OCT) demonstrates thickened hyperreflective epithelium with an abrupt transition between abnormal and normal epithelium in OSSN lesions and this has also been shown to mimic histopathology findings...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27749454/nodulo-ulcerative-ocular-surface-squamous-neoplasia-in-6-patients-a-rare-presentation
#18
Swathi Kaliki, Suzanne K Freitag, James Chodosh
PURPOSE: To describe clinical presentation and histopathological features of a nodulo-ulcerative variant of ocular surface squamous neoplasia (OSSN). METHODS: Retrospective study. RESULTS: Six patients were identified with a nodulo-ulcerative variant of OSSN. Mean age at presentation was 56 years. One patient was immunosuppressed because of human immunodeficiency virus infection. The initial misdiagnosis was necrotizing scleritis/sclerokeratitis (n = 4), intraepithelial neoplasia (n = 1), and chalazion (n = 1)...
March 2017: Cornea
https://www.readbyqxmd.com/read/27714903/risk-factors-for-ocular-surface-squamous-neoplasia-in-kenya-a-case-control-study
#19
Stephen Gichuhi, Ephantus Macharia, Joy Kabiru, Alain M'bongo Zindamoyen, Hillary Rono, Ernest Ollando, Joseph Wachira, Rhoda Munene, Timothy Onyuma, Walter G Jaoko, Mandeep S Sagoo, Helen A Weiss, Matthew J Burton
OBJECTIVE: To determine modifiable risk factors of ocular surface squamous neoplasia (OSSN) in Kenya using disease-free controls. METHODS: Adults with conjunctival lesions were recruited at four eye care centres in Kenya and underwent excision biopsy. An equal number of controls having surgery for conditions not affecting the conjunctiva and unrelated to ultraviolet light were group-matched to cases by age group, sex and eye care centre. Associations of risk factors with OSSN were evaluated using multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs)...
December 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27661075/exfoliative-cytology-in-the-diagnosis-of-ocular-surface-squamous-neoplasms
#20
Kim Vieira Kayat, Paulo Elias Correa Dantas, Sérgio Felberg, Maria Antonieta Galvão, Mauro Ajaj Saieg
PURPOSE: Surface tumors of the eye comprise an ample spectrum of diseases with various clinical manifestations. Diagnosis has been traditionally achieved through core biopsies, but cytology is an innovative, fast, and minimally invasive method. The objective of this study was to investigate the use of exfoliative cytology as an alternative method for the detection of ocular surface squamous neoplasm (OSSN). METHODS: Exfoliative cytology of the lesions was performed by collecting smears using plastic brushes followed by smearing the cells onto slides and subsequently fixing them in 90% alcohol...
January 2017: Cornea
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