keyword
MENU ▼
Read by QxMD icon Read
search

OSSN

keyword
https://www.readbyqxmd.com/read/27905329/recombinant-interferon-alpha-2b-for-ocular-surface-squamous-neoplasia-an-efficient-and-cost-effective-treatment-modality-in-asian-indian-patients
#1
Swathi Kaliki, Swati Singh, Sadiya Iram, Dharani Tripuraneni
PURPOSE: The purpose was to study the efficacy of interferon alpha 2b (INF α2b) in the treatment of ocular surface squamous neoplasia (OSSN) and analyze its cost-effectiveness in India. STUDY DESIGN: This was a retrospective study of thirty patients with OSSN treated with topical INF α2b (1 MIU/cc) ± perilesional INF α2b (5 MIU/cc). RESULTS: The tumor involved cornea (n = 9, 30%), conjunctivo-limbal-corneal surface (n = 19, 63%), or bulbar conjunctiva (n = 2, 7%)...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27832940/concomitant-simple-limbal-epithelial-transplantation-after-surgical-excision-of-ocular-surface-squamous-neoplasia
#2
Swathi Kaliki, Faraz Ali Mohammad, Prerana Tahiliani, Virender S Sangwan
PURPOSE: To compare the surgical outcomes of ocular surface squamous neoplasia (OSSN) following wide excisional biopsy with and without primary simple limbal epithelial transplantation (p-SLET). DESIGN: Non-randomized clinical study with historical controls METHODS: Setting: Single-institutional study PATIENTS: 8 patients who underwent wide excisional biopsy of OSSN without p-SLET (historical controls) and 7 patients with p-SLET (cases) INTERVENTION: Wide excisional biopsy, p-SLET MAIN OUTCOME MEASURES: Limbal stem cell deficiency (LSCD) RESULTS: The tumor features between cases versus historical controls including mean number of limbal clock hours affected by OSSN (6 vs 4; p=0...
November 7, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27826936/ocular-surface-squamous-neoplasia-as-the-initial-presenting-sign-of-human-immunodeficiency-virus-infection-in-60-asian-indian-patients
#3
Swathi Kaliki, Saurabh Kamal, Saba Fatima
PURPOSE: To study the importance of routine human immunodeficiency virus (HIV) screening in patients with ocular surface squamous neoplasia (OSSN) and describe their clinical features and management. METHODS: Retrospective study. RESULTS: Of 228 cases of OSSN screened for HIV by enzyme-linked immunosorbent assay, 86 (38%) patients were HIV positive. Of these 86 patients, 60 (70%) were unaware of their HIV-positive status prior to HIV screening...
November 8, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27800176/anterior-segment-imaging-in-ocular-surface-squamous-neoplasia
#4
REVIEW
Sally S Ong, Gargi K Vora, Preeya K Gupta
Recent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN) is diagnosed and monitored. Ultrasound biomicroscopy (UBM) has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVCM) shows enlarged and irregular nuclei with hyperreflective cells in OSSN lesions and this has been found to correlate with histopathology findings. Anterior segment optical coherence tomography (AS-OCT) demonstrates thickened hyperreflective epithelium with an abrupt transition between abnormal and normal epithelium in OSSN lesions and this has also been shown to mimic histopathology findings...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27749454/nodulo-ulcerative-ocular-surface-squamous-neoplasia-in-6-patients-a-rare-presentation
#5
Swathi Kaliki, Suzanne K Freitag, James Chodosh
PURPOSE: To describe clinical presentation and histopathological features of a nodulo-ulcerative variant of ocular surface squamous neoplasia (OSSN). METHODS: Retrospective study. RESULTS: Six patients were identified with a nodulo-ulcerative variant of OSSN. Mean age at presentation was 56 years. One patient was immunosuppressed because of human immunodeficiency virus infection. The initial misdiagnosis was necrotizing scleritis/sclerokeratitis (n = 4), intraepithelial neoplasia (n = 1), and chalazion (n = 1)...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27714903/risk-factors-for-ocular-surface-squamous-neoplasia-in-kenya-a-case-control-study
#6
Stephen Gichuhi, Ephantus Macharia, Joy Kabiru, Alain M'bongo Zindamoyen, Hillary Rono, Ernest Ollando, Joseph Wachira, Rhoda Munene, Timothy Onyuma, Walter G Jaoko, Mandeep S Sagoo, Helen A Weiss, Matthew J Burton
OBJECTIVE: To determine modifiable risk factors of ocular surface squamous neoplasia (OSSN) in Kenya using disease-free controls. METHODS: Adults with conjunctival lesions were recruited at four eye care centres in Kenya and underwent excision biopsy. An equal number of controls having surgery for conditions not affecting the conjunctiva and unrelated to ultraviolet light were group-matched to cases by age group, sex and eye care centre. Associations of risk factors with OSSN were evaluated using multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs)...
December 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27661075/exfoliative-cytology-in-the-diagnosis-of-ocular-surface-squamous-neoplasms
#7
Kim Vieira Kayat, Paulo Elias Correa Dantas, Sérgio Felberg, Maria Antonieta Galvão, Mauro Ajaj Saieg
PURPOSE: Surface tumors of the eye comprise an ample spectrum of diseases with various clinical manifestations. Diagnosis has been traditionally achieved through core biopsies, but cytology is an innovative, fast, and minimally invasive method. The objective of this study was to investigate the use of exfoliative cytology as an alternative method for the detection of ocular surface squamous neoplasm (OSSN). METHODS: Exfoliative cytology of the lesions was performed by collecting smears using plastic brushes followed by smearing the cells onto slides and subsequently fixing them in 90% alcohol...
September 21, 2016: Cornea
https://www.readbyqxmd.com/read/27584160/differential-expression-of-stem-cell-markers-in-ocular-surface-squamous-neoplasia
#8
Dilip Kumar Mishra, Uppala Veena, Swathi Kaliki, Abhinav Reddy Kethiri, Virender S Sangwan, Mohammed Hasnat Ali, Milind N Naik, Vivek Singh
Ocular Surface Squamous Neoplasm (OSSN) is the neoplasia arising from the conjunctiva, cornea and limbus. OSSN ranges from mild, moderate, severe dysplasia, carcinoma in situ (CIS) to squamous cell carcinoma (SCC). Recent findings on cancer stem cells theory indicate that population of stem-like cell as in neoplasia determines its heterogeneity and complexity leading to varying tumor development of metastatic behavior and recurrence. Cancer stem cell markers are not much explored in the cases of OSSN. In the present study, we aim to evaluate the expression of stem cells using stem cell markers mainly p63, ABCG2, c-KIT (CD117) and CD44 in OSSN tissue, which could have prognostic significance...
2016: PloS One
https://www.readbyqxmd.com/read/27442321/primary-simple-limbal-epithelial-transplantation-along-with-excisional-biopsy-in-the-management-of-extensive-ocular-surface-squamous-neoplasia
#9
Vikas Mittal, Purvasha Narang, Vikas Menon, Ruchi Mittal, Santosh Honavar
PURPOSE: To describe the utility of simple limbal epithelial transplantation (SLET) along with tumor excision in the management of extensive ocular surface squamous neoplasia (OSSN) to avoid limbal stem cell deficiency (LSCD). METHODS: This case report describes the management of a 75-year-old man clinically diagnosed with OSSN involving more than 3 quadrants of limbus. The excisional biopsy of tumor along with 4-mm healthy margin led to a complete loss of the limbus, which was restored by limbal epithelial cell transplantation using the SLET technique in the same setting...
July 20, 2016: Cornea
https://www.readbyqxmd.com/read/27330387/high-frequency-of-squamous-intraepithelial-neoplasia-in-pterygium-related-to-low-ultraviolet-light-exposure
#10
Pablo Zoroquiain, Samir Jabbour, Sultan Aldrees, Natalia Villa, Vasco Bravo-Filho, Helena Dietrich, Patrick Logan, Miguel N Burnier
PURPOSE: The aim of this study was to determine the frequency of clinically unsuspected ocular surface squamous neoplasia (OSSN) in cases of biopsied pterygium (PT). METHODS: We reviewed 15,016 cases presented at the Henry C. Witelson Ocular Pathology Laboratory during the period 1993-2013. All cases with a clinical diagnosis of PT were included. Histopathological diagnoses were reviewed and demographic data were retrieved from histopathological request forms. All cases associated with OSSN were re-evaluated independently by two ocular pathologists...
April 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/27300720/-complications-in-the-treatment-of-ocular-surface-squamous-neoplasia-with-interferon-%C3%AE-%C3%A2-2b-in-rheumatoid-arthritis
#11
E Torres Suárez, R Pinheiro, N Schrage
BACKGROUND: Interferon α‑2b (IFN α‑2b) is an established and well-tolerated treatment for ocular surface squamous neoplasia (OSSN). METHOD: Report of complications in two patients with OSSN and rheumatoid arthritis treated with adjuvant topical IFN α‑2b. RESULTS: One patient developed a scleral melt and the other one severe keratitis. After discontinuing treatment with IFN α‑2b both patients showed considerable improvement. CONCLUSION: Immunosuppressed patients with OSSN under topical IFN α‑2b should be closely monitored for early detection of complications...
June 14, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27198842/topical-fluorouracil-after-surgery-for-ocular-surface-squamous-neoplasia-in-kenya-a-randomised-double-blind-placebo-controlled-trial
#12
Stephen Gichuhi, Ephantus Macharia, Joy Kabiru, Alain M'bongo Zindamoyen, Hilary Rono, Ernest Ollando, Joseph Wachira, Rhoda Munene, John Maina, Timothy Onyuma, Mandeep S Sagoo, Helen A Weiss, Matthew J Burton
BACKGROUND: Ocular surface squamous neoplasia (OSSN) is an aggressive eye tumour particularly affecting people with HIV in Africa. Primary treatment is surgical excision; however, tumour recurrence is common. We assessed the effect of fluorouracil 1% eye drops after surgery on recurrence. METHODS: We did this multicentre, randomised, placebo-controlled trial in four centres in Kenya. We enrolled patients with histologically proven OSSN aged at least 18 years. After standard surgical excision, participants were randomly allocated to receive either topical fluorouracil 1% or placebo four times a day for 4 weeks...
June 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27166000/xeroderma-pigmentosum-with-bilateral-ocular-surface-squamous-neoplasia-and-review-of-the-literature
#13
Charudutt Kalamkar, Nishant Radke, Amrita Mukherjee, Snehal Radke
Xeroderma pigmentosum is a rare genetic disorder associated with various ocular malignancies. Here we report a single paediatric case of xeroderma pigmentosum with bilateral ocular surface squamous neoplasia (OSSN) presenting with diffuse lesion in one eye and a large mass in the other eye. Diffuse OSSN in one eye was treated with topical chemotherapy using mitomycin-C (0.04%) and the large OSSN in the other eye was treated with a combination of surgery and topical chemotherapy. Long-term follow-up and a multimodality treatment approach are necessary to identify and manage recurrences of OSSN in XP...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27099616/evaluation-of-the-radiotherapy-management-of-ocular-surface-squamous-neoplasia-in-a-high-hiv-prevalence-setting-a-retrospective-review
#14
Ntokozo Ndlovu, Sandra Ndarukwa, Webster Kadzatsa, Simbarashe Rusakaniko
BACKGROUND: This article evaluates a single institute's radiotherapy management of OSSN, a previously regarded as rare malignancy, for possible future development of strategies to clearly define the role of adjuvant radiotherapy in improving treatment outcomes. MATERIALS AND METHODS: A retrospective review of 153 patients treated from January 2003 to December 2009. RESULTS: There was no difference in OSSN prevalence by gender (male to female ratio 1...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27061904/long-term-outcome-of-amniotic-membrane-transplantation-combined-with-mitomycin-c-for-conjunctival-reconstruction-after-ocular-surface-squamous-neoplasia-excision
#15
Kazuomi Hanada, Noriko Nishikawa, Naoyuki Miyokawa, Akitoshi Yoshida
The aim of the study is to evaluate the long-term clinical results of amniotic membrane transplantation (AMT) combined with mitomycin C (MMC) for reconstruction of conjunctival defects created during the excision of ocular surface squamous neoplasia (OSSN). Eight consecutive eyes of seven patients (five males and two females; mean age, 64 ± 19 years) treated by one surgeon (KH) were included in this study. AMT was performed after excision of a mass region, along with 0.04 % MMC treatment for the exposed sclera...
April 9, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27030104/topical-5-fluorouracil-1-as-primary-treatment-for-ocular-surface-squamous-neoplasia
#16
Madhura G Joag, Adam Sise, Juan Carlos Murillo, Ibrahim Osama Sayed-Ahmed, James R Wong, Carolina Mercado, Anat Galor, Carol L Karp
PURPOSE: To determine the efficacy of topical 5-fluorouracil 1% (5-FU) as a primary treatment of ocular surface squamous neoplasia (OSSN). DESIGN: Retrospective study. PARTICIPANTS: Topical 5-FU was used as primary therapy in 44 patients with OSSN. METHODS: 5-Fluorouracil 1% administered topically 4 times daily for 1 week followed by a drug holiday of 3 weeks. Patients were identified through a pharmacy database. Patients were excluded if 5-FU was used as adjuvant therapy, if they did not complete therapy, or if they were still actively receiving treatment for OSSN at the time of last follow-up...
July 2016: Ophthalmology
https://www.readbyqxmd.com/read/26890663/surgery-versus-interferon-alpha-2b-treatment-strategies-for-ocular-surface-squamous-neoplasia-a-literature-based-decision-analysis
#17
Andrew N Siedlecki, Stephanie Tapp, Anna N A Tosteson, Robin J Larson, Carol L Karp, Thomas Lietman, Michael E Zegans
PURPOSE: To compare treatment strategies for ocular surface squamous neoplasia (OSSN), ranging from surgical excision to empiric topical interferon alpha-2b (IFN-α2b). METHODS: A decision model was constructed to determine which of 4 treatment strategies minimized expected persistence/recurrence of disease in patients with OSSN: excision followed by repeat excision for positive surgical margins, excision followed by IFN-α2b for positive margins, incisional biopsy followed by IFN-α2b for positive biopsies, and empiric treatment with IFN-α2b...
May 2016: Cornea
https://www.readbyqxmd.com/read/26843453/elevated-expression-of-abcb5-in-ocular-surface-squamous-neoplasia
#18
Passara Jongkhajornpong, Takahiro Nakamura, Chie Sotozono, Maho Nagata, Tsutomu Inatomi, Shigeru Kinoshita
ATP-binding cassette subfamily B member 5 (ABCB5) is a new member of the ATP-binding cassette superfamily and has been reported as a novel marker for limbal stem cell (LSC), which is essential for corneal homeostasis. ABCB5 expression has also been discovered in the subpopulation of several cancer cells containing the cancer stem cell (CSC). However, the pathogenetic relationship between LSC and CSC and ABCB5 in the ocular surface squamous neoplasm (OSSN) is still entirely unknown. To improve understanding of the role of ABCB5 in OSSN, we performed immunohistochemistry for ABCB5 in nine OSSN case series...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26735858/evaluation-for-high-risk-hpv-in-squamous-cell-carcinomas-and-precursor-lesions-arising-in-the-conjunctiva-and-lacrimal-sac
#19
Amir H Afrogheh, Frederick A Jakobiec, Rebecca Hammon, Hans E Grossniklaus, James Rocco, Neal I Lindeman, Peter M Sadow, William C Faquin
High-risk human papilloma virus (HR-HPV) is a well-established causative agent of oropharyngeal squamous cell carcinoma (SCC). In addition, HR-HPV has occasionally been reported to be present in dysplastic and malignant lesions of the conjunctiva and lacrimal sac, although its overall incidence and etiological role in periocular SCC are controversial. Sequential surgical samples of 52 combined cases of invasive SCC (I-SCC) and SCC in situ (SCCIS) from 2 periocular sites (conjunctiva and lacrimal sac) diagnosed over a 14-year period (2000 to 2014) were selected for evaluation, and relevant patient characteristics were documented...
April 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26686965/surgical-versus-medical-treatment-of-ocular-surface-squamous-neoplasia-a-cost-comparison
#20
COMPARATIVE STUDY
Christina S Moon, Afshan A Nanji, Anat Galor, Kathryn E McCollister, Carol L Karp
PURPOSE: The objective of this study was to compare the cost associated with surgical versus interferon-alpha 2b (IFNα2b) treatment for ocular surface squamous neoplasia (OSSN). DESIGN: A matched, case-control study. PARTICIPANTS: A total of 98 patients with OSSN, 49 of whom were treated surgically and 49 of whom were treated medically. METHODS: Patients with OSSN treated with IFNα2b were matched to patients treated with surgery on the basis of age and date of treatment initiation...
March 2016: Ophthalmology
keyword
keyword
10995
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"