keyword
MENU ▼
Read by QxMD icon Read
search

ceacam1

keyword
https://www.readbyqxmd.com/read/28402947/overexpression-of-the-transcription-factor-atf3-with-a-regulatory-molecular-signature-associates-with-the-pathogenic-development-of-colorectal-cancer
#1
Feng Yan, Le Ying, Xiaofang Li, Bin Qiao, Qiaohong Meng, Liang Yu, Xiangliang Yuan, Shu-Ting Ren, David W Chan, Liyun Shi, Peihua Ni, Xuefeng Wang, Dakang Xu, Yiqun Hu
The identification of novel biomarkers of cancer is important for improved diagnosis and prognosis. With an abundant amount of resources in the publicly available database, such as the Cancer Genome Atlas (TCGA) database, an integrative strategy is used to systematically characterize the aberrant patterns of colorectal cancer (CRC) based on RNA-Seq, chromatin immunoprecipitation sequencing (ChIP-Seq), tissue microarray (TMA), gene profiling and molecular signatures. The expression of the transcription factor ATF3 was elevated in human CRC specimens in a TMA by immunochemistry analysis compared to the adjacent normal tissues...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396653/reduced-hepatic-carcinoembryonic-antigen-related-cell-adhesion-molecule-1-level-in-obesity
#2
Garrett Heinrich, Harrison T Muturi, Khadijeh Rezaei, Qusai Y Al-Share, Anthony M DeAngelis, Thomas A Bowman, Hilda E Ghadieh, Simona S Ghanem, Deqiang Zhang, Robert S Garofalo, Lei Yin, Sonia M Najjar
Impairment of insulin clearance is being increasingly recognized as a critical step in the development of insulin resistance and metabolic disease. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Null deletion or liver-specific inactivation of Ceacam1 in mice causes a defect in insulin clearance, insulin resistance, steatohepatitis, and visceral obesity. Immunohistological analysis revealed reduction of hepatic CEACAM1 in obese subjects with fatty liver disease...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28385529/matrix-metalloproteinase12-facilitated-platelet-activation-by-shedding-carcinoembryonic-antigen-related-cell-adhesion-molecule1
#3
Jing Wang, Yujia Ye, Guoqing Wei, Wei Hu, Linhua Li, Si Lu, Zhaohui Meng
Platelets express several MMPs that modulate their activation, which in turn regulates thrombosis, but the exact mechanism is unclear. This study evaluated the platelet expression of MMP12 and platelet activation by shedding CEACAM1 mediated by MMP12. Expression of MMP12 was measured by RT-PCR, Western blot (WB), and casein zymography in platelet from whole blood by gel filtration over plateletpheresis. The site of CEACAM1 cleavage by MMP12 was determined by high performance liquid chromatography (HPLC), mass spectrometry, WB and flow cytometry (FCM)...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28332308/ceacam1-long-isoform-has-opposite-effects-on-the-growth-of-human-mastocytosis-and-medullary-thyroid-carcinoma-cells
#4
Chiyuki Ueshima, Tatsuki R Kataoka, Yusuke Takei, Masahiro Hirata, Akihiko Sugimoto, Mitsuyoshi Hirokawa, Yoshimichi Okayama, Richard S Blumberg, Hironori Haga
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in a number of tumor cell types. The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing isoforms of this molecule which possess a long cytoplasmic tail (CEACAM1-L) generally play inhibitory roles in cell function by interacting with Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and/or SHP-2. Src family kinases (SFKs) are also known to bind to and phosphorylate CEACAM1-L isoforms. Here, we report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC) lines, when compared with their expression in nonneoplastic mast cells or nonneoplastic C cells...
April 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28314278/elevated-preoperative-serum-cea-level-is-associated-with-poor-prognosis-in-patients-with-hepatocellular-carcinoma-through-the-epithelial-mesenchymal-transition
#5
Masato Yoshikawa, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Jun Higashijima, Shuichi Iwahashi, Y U Saito, Chie Takasu, Shinichiro Yamada, Daichi Ishikawa, Hiroki Teraoku, Atsushi Takata, Toshiaki Yoshimoto, Mitsuo Shimada
BACKGROUND: Serum carcinoembryonic antigen (CEA) is used as an indicator of tumor progression in a variety of carcinomas. A subset of patients with hepatocellular carcinoma (HCC) exhibit increased serum CEA level, but the significance of this is unclear. In this study, we investigated the prognosis of patients with HCC with increased serum CEA, and explored the correlations with expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and epithelial-mesenchymal transition (EMT) and tumor angiogenesis...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28292985/binding-of-candida-albicans-to-human-ceacam1-and-ceacam6-modulates-the-inflammatory-response-of-intestinal-epithelial-cells
#6
Esther Klaile, Mario M Müller, Miriam R Schäfer, Ann-Katrin Clauder, Sabina Feer, Kerstin A Heyl, Magdalena Stock, Tilman E Klassert, Peter F Zipfel, Bernhard B Singer, Hortense Slevogt
Candida albicans colonizes human mucosa, including the gastrointestinal tract, as a commensal. In immunocompromised patients, C. albicans can breach the intestinal epithelial barrier and cause fatal invasive infections. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1; CD66a), CEACAM5 (CEA), and CEACAM6 (CD66c) are immunomodulatory receptors expressed on human mucosa and are recruited by bacterial and viral pathogens. Here we show for the first time that a fungal pathogen (i.e., C. albicans) also binds directly to the extracellular domain of human CEACAM1, CEACAM3, CEACAM5, and CEACAM6...
March 14, 2017: MBio
https://www.readbyqxmd.com/read/28275050/novel-thiosemicarbazones-inhibit-lysine-rich-ceacam1-co-isolated-lyric-and-the-lyric-induced-epithelial-mesenchymal-transition-via-up-regulation-of-n-myc-downstream-regulated-gene-1-ndrg1
#7
Ruxing Xi, Ivan Ho Yuen Pun, Sharleen V Menezes, Leyla Fouani, Danuta S Kalinowski, Michael L H Huang, Xiaozhi Zhang, Des R Richardson, Zaklina Kovacevic
Tumor necrosis factor α (TNFα) plays a vital role in cancer progression, being associated with inflammation and promotion of cancer angiogenesis and metastasis. The effects of TNFα are mediated by its down-stream target, the oncogene, lysine-rich CEACAM1 co-isolated protein (LYRIC; also known as metadherin or astrocyte elevated gene-1). LYRIC plays an important role in activating the nuclear factor-κB (NF-κB) signaling pathway, which controls multiple cellular processes, including proliferation, apoptosis, migration, etc...
March 8, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28184213/loss-of-hepatic-ceacam1-a-unifying-mechanism-linking-insulin-resistance-to-obesity-and-non-alcoholic-fatty-liver-disease
#8
REVIEW
Garrett Heinrich, Hilda E Ghadieh, Simona S Ghanem, Harrison T Muturi, Khadijeh Rezaei, Qusai Y Al-Share, Thomas A Bowman, Deqiang Zhang, Robert S Garofalo, Lei Yin, Sonia M Najjar
The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in particular in the context of its relationship to insulin resistance and visceral obesity. Work on the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in mice has resolved some of the related questions. CEACAM1 promotes insulin clearance by enhancing the rate of uptake of the insulin-receptor complex. It also mediates a negative acute effect of insulin on fatty acid synthase activity. This positions CEACAM1 to coordinate the regulation of insulin and lipid metabolism...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28038383/co-expression-of-tim-3-and-ceacam1-promotes-t-cell-exhaustion-in-colorectal-cancer-patients
#9
Yang Zhang, Pengcheng Cai, Lei Li, Liang Shi, Panpan Chang, Tao Liang, Qianqian Yang, Yang Liu, Lin Wang, Lihua Hu
T-cell immunoglobulin domain and mucin domain-3(TIM-3) is an activation induced inhibitory molecule involved in immune tolerance and is recently reported to induce T cell exhaustion which is mediated by carcinoembryonic antigen cell adhesion molecule 1(CEACAM1), another well-known molecule expressed on activated T cells and involved in T cell inhibition. To investigate the expression of TIM-3 and CEACAM1 on circulating CD8(+) T cells and tumor infiltrating lymphocytes (TILs), 65 diagnosed colorectal cancer (CRC) patients and 38 healthy controls were enrolled in this study and the results showed that TIM-3 and CEACAM1 were both highly expressed on circulating CD8(+) T cells in CRC patients and elevated on TILs compared with paraneoplastic T cells...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28002407/identification-of-an-atypical-monocyte-and-committed-progenitor-involved-in-fibrosis
#10
Takashi Satoh, Katsuhiro Nakagawa, Fuminori Sugihara, Ryusuke Kuwahara, Motooki Ashihara, Fumihiro Yamane, Yosuke Minowa, Kiyoharu Fukushima, Isao Ebina, Yoshichika Yoshioka, Atsushi Kumanogoh, Shizuo Akira
Monocytes and macrophages comprise a variety of subsets with diverse functions. It is thought that these cells play a crucial role in homeostasis of peripheral organs, key immunological processes and development of various diseases. Among these diseases, fibrosis is a life-threatening disease of unknown aetiology. Its pathogenesis is poorly understood, and there are few effective therapies. The development of fibrosis is associated with activation of monocytes and macrophages. However, the specific subtypes of monocytes and macrophages that are involved in fibrosis have not yet been identified...
January 5, 2017: Nature
https://www.readbyqxmd.com/read/27852220/coevolution-of-paired-receptors-in-xenopus-carcinoembryonic-antigen-related-cell-adhesion-molecule-families-suggests-appropriation-as-pathogen-receptors
#11
Wolfgang Zimmermann, Robert Kammerer
BACKGROUND: In mammals, CEACAM1 and closely related members represent paired receptors with similar extracellular ligand-binding regions and cytoplasmic domains with opposing functions. Human CEACAM1 and CEACAM3 which have inhibitory ITIM/ITSM and activating ITAM-like motifs, respectively, in their cytoplasmic regions are such paired receptors. Various bacterial pathogens bind to CEACAM1 on epithelial and immune cells facilitating both entry into the host and down-regulation of the immune response whereas interaction with granulocyte-specific CEACAM3 leads to their uptake and destruction...
November 16, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27777319/role-for-hepatic-ceacam1-in-regulating-fatty-acid-metabolism-along-the-adipocyte-hepatocyte-axis
#12
Lucia Russo, Hilda E Ghadieh, Simona S Ghanem, Qusai Y Al-Share, Zachary N Smiley, Cara Gatto-Weis, Emily L Esakov, Marcia F McInerney, Garrett Heinrich, Xin Tong, Lei Yin, Sonia M Najjar
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid synthase activity. Feeding C57BL/6J male mice with a high-fat (HF) diet for 3-4 weeks triggered a >60% decrease in hepatic CEACAM1 levels to subsequently impair insulin clearance and cause systemic insulin resistance and hepatic steatosis. This study aimed at investigating whether lipolysis drives reduction in hepatic CEACAM1 and whether this constitutes a key mechanism leading to diet-induced metabolic abnormalities...
December 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27748768/helicobacter-pylori-adhesin-hopq-engages-in-a-virulence-enhancing-interaction-with-human-ceacams
#13
Anahita Javaheri, Tobias Kruse, Kristof Moonens, Raquel Mejías-Luque, Ayla Debraekeleer, Carmen I Asche, Nicole Tegtmeyer, Behnam Kalali, Nina C Bach, Stephan A Sieber, Darryl J Hill, Verena Königer, Christof R Hauck, Roman Moskalenko, Rainer Haas, Dirk H Busch, Esther Klaile, Hortense Slevogt, Alexej Schmidt, Steffen Backert, Han Remaut, Bernhard B Singer, Markus Gerhard
Helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. Here, we identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of H. pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. HopQ-CEACAM binding is glycan-independent and targeted to the N-domain. H. pylori binding induces CEACAM1-mediated signalling, and the HopQ-CEACAM1 interaction enables translocation of the virulence factor CagA into host cells and enhances the release of pro-inflammatory mediators such as interleukin-8...
October 17, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27748756/helicobacter-pylori-exploits-human-ceacams-via-hopq-for-adherence-and-translocation-of-caga
#14
Verena Königer, Lea Holsten, Ute Harrison, Benjamin Busch, Eva Loell, Qing Zhao, Daniel A Bonsor, Alexandra Roth, Arnaud Kengmo-Tchoupa, Stella I Smith, Susanna Mueller, Eric J Sundberg, Wolfgang Zimmermann, Wolfgang Fischer, Christof R Hauck, Rainer Haas
Helicobacter pylori (Hp) strains that carry the cag type IV secretion system (cag-T4SS) to inject the cytotoxin-associated antigen A (CagA) into host cells are associated with peptic ulcer disease and gastric adenocarcinoma. CagA translocation by Hp is mediated by β1 integrin interaction of the cag-T4SS. However, other cellular receptors or bacterial outer membrane adhesins essential for this process are unknown. Here, we identify the HopQ protein as a genuine Hp adhesin, exploiting defined members of the carcinoembryonic antigen-related cell adhesion molecule family (CEACAMs) as host cell receptors...
October 17, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27695943/the-role-of-cea-related-cell-adhesion-molecule-1-ceacam1-in-vascular-homeostasis
#15
REVIEW
Uwe Rueckschloss, Stefanie Kuerten, Süleyman Ergün
Carcinoembryonic antigen (CEA)-related cell adhesion molecules belong to the immunoglobulin superfamily, are expressed in a broad spectrum of tissues and cell types and exert context-dependent activating as well as inhibitory effects. Among these molecules, the CEA-related cell adhesion molecule-1 (CEACAM1) is a transmembrane molecule with an extracellular, a transmembrane and a cytoplasmic domain. The latter contains immunoreceptor tyrosine-based inhibitory motifs and functions as a signaling molecule. CEACAM1 can form homo- and heterodimers which is relevant for its signaling activities...
December 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27662905/fenofibrate-decreases-insulin-clearance-and-insulin-secretion-to-maintain-insulin-sensitivity
#16
Sadeesh K Ramakrishnan, Lucia Russo, Simona S Ghanem, Payal R Patel, Ana Maria Oyarce, Garrett Heinrich, Sonia M Najjar
High fat diet reduces the expression of CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), a transmembrane glycoprotein that promotes insulin clearance and down-regulates fatty acid synthase activity in the liver upon its phosphorylation by the insulin receptor. Because peroxisome proliferator-activated receptor α (PPARα) transcriptionally suppresses CEACAM1 expression, we herein examined whether high fat down-regulates CEACAM1 expression in a PPARα-dependent mechanism. By activating PPARα, the lipid-lowering drug fenofibrate reverses dyslipidemia and improves insulin sensitivity in type 2 diabetes in part by promoting fatty acid oxidation...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27642217/ceacam1-expression-and-role-in-melanocyte-transformation
#17
REVIEW
Gabriela Turcu, Roxana Ioana Nedelcu, Daniela Adriana Ion, Alice Brînzea, Mirela Daniela Cioplea, Lucia Beatrice Jilaveanu, Sabina Andrada Zurac
Metastases represent the main cause of death in melanoma patients. Despite the current optimized targeted therapy or immune checkpoint inhibitors the treatment of metastatic melanoma is unsatisfactory. Because of the poor prognosis of advanced melanoma there is an urgent need to identify new biomarkers to differentiate melanoma cells from normal melanocytes, to stratify patients according to their risk, and to identify subgroups of patients that require close follow-up or more aggressive therapy. Furthermore, melanoma progression has been associated with the dysregulation of cell adhesion molecules...
2016: Disease Markers
https://www.readbyqxmd.com/read/27634893/suppression-of-human-metapneumovirus-hmpv-infection-by-the-innate-sensing-gene-ceacam1
#18
Mohammad Diab, Alon Vitenshtein, Yaron Drori, Rachel Yamin, Oded Danziger, Rachel Zamostiano, Michal Mandelboim, Eran Bacharach, Ofer Mandelboim
The innate sensing system is equipped with PRRs specialized in recognizing molecular structures (PAMPs) of various pathogens. This leads to the induction of anti-viral genes and inhibition of virus growth. Human Metapneumovirus (HMPV) is a major respiratory virus that causes an upper and lower respiratory tract infection in children. In this study we show that upon HMPV infection, the innate sensing system detects the viral RNA through the RIG-I sensor leading to induction of CEACAM1 expression. We further show that CEACAM1 is induced via binding of IRF3 to the CEACAM1 promoter...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27572314/ceacam1-controls-the-emt-switch-in-murine-mammary-carcinoma-in-vitro-and-in-vivo
#19
Florian Wegwitz, Eva Lenfert, Daniela Gerstel, Lena von Ehrenstein, Julia Einhoff, Geske Schmidt, Matthew Logsdon, Johanna Brandner, Gisa Tiegs, Nicole Beauchemin, Christoph Wagener, Wolfgang Deppert, Andrea Kristina Horst
We analyzed the molecular basis for carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-controlled inhibition of epithelial-mesenchymal transition (EMT) in a mouse model for mammary adenocarcinoma (WAP-T mice). We demonstrate that silencing of CEACAM1 in WAP-T tumor-derived G-2 cells induces epithelial-mesenchymal plasticity (EMP), as evidenced by typical changes of gene expression, morphology and increased invasion. In contrast, reintroduction of CEACAM1 into G-2 cells reversed up-regulation of genes imposing mesenchymal transition, as well as cellular invasion...
September 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27471271/glycosylation-alters-dimerization-properties-of-a-cell-surface-signaling-protein-carcinoembryonic-antigen-related-cell-adhesion-molecule-1-ceacam1
#20
You Zhuo, Jeong-Yeh Yang, Kelley W Moremen, James H Prestegard
Human carcinoembryonic antigen-related cell adhesion molecule 1 (C?/Au: EACAM1) is a cell-surface signaling molecule involved in cell adhesion, proliferation, and immune response. It is also implicated in cancer angiogenesis, progression, and metastasis. This diverse set of effects likely arises as a result of the numerous homophilic and heterophilic interactions that CEACAM1 can have with itself and other molecules. Its N-terminal Ig variable (IgV) domain has been suggested to be a principal player in these interactions...
September 16, 2016: Journal of Biological Chemistry
keyword
keyword
109942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"