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https://www.readbyqxmd.com/read/26916782/finite-element-modelling-of-radial-lentotomy-cuts-to-improve-the-accommodation-performance-of-the-human-lens
#1
H J Burd, G S Wilde
PURPOSE: The use of a femtosecond laser to form planes of cavitation bubbles within the ocular lens has been proposed as a potential treatment for presbyopia. The intended purpose of these planes of cavitation bubbles (referred to in this paper as 'cutting planes') is to increase the compliance of the lens, with a consequential increase in the amplitude of accommodation. The current paper describes a computational modelling study, based on three-dimensional finite element analysis, to investigate the relationship between the geometric arrangement of the cutting planes and the resulting improvement in lens accommodation performance...
April 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/26275131/measurement-of-ex-vivo-porcine-lens-shape-during-simulated-accommodation-before-and-after-fs-laser-treatment
#2
Jan Hahn, Michael Fromm, Fedaa Al Halabi, Silke Besdo, Holger Lubatschowski, Tammo Ripken, Alexander Krüger
PURPOSE: According to Helmholtz, accommodation is based on the flexibility of the crystalline lens, which decreases with age, causing presbyopia. With femtosecond (fs)-lentotomy treatment, it is possible to restore the flexibility of presbyopic lenses. The efficiency of the treatment can be systematically evaluated using the finite element method based on experimental data. The purpose of this study was to quantify the shape change of ex vivo lenses in different accommodation states according to the fs-lentotomy treatment...
August 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/23926059/safety-evaluation-of-femtosecond-lentotomy-on-the-porcine-lens-by-optical-measurement-with-50-femtosecond-laser-pulses
#3
Jiaying Zhang, Rui Wang, Bing Chen, Peng Ye, Wei Zhang, Hongyou Zhao, Jie Zhen, Yifei Huang, Zhiyi Wei, Ying Gu
BACKGROUND AND OBJECTIVE: The optimized parameters of femtosecond (fs) lentotomy, an innovative strategy for presbyopia, have been further discussed regarding the safety of the procedure for eyeballs. This article's aim was to prove the safety and feasibility of the fs lentotomy procedure with 50-fs laser pulses. STUDY DESIGN/MATERIALS AND METHODS: This was an experimental study in which the safety of fs lentotomy by optical measurement was tested. The experiment was performed on 49 porcine crystalline lenses by 50-fs laser pulses at a central wavelength of 800 nm and scanning focusing optics with a numerical aperture (NA) of 0...
September 2013: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/20437418/femtosecond-lentotomy-generating-gliding-planes-inside-the-crystalline-lens-to-regain-accommodation-ability
#4
Holger Lubatschowski, Silvia Schumacher, Michael Fromm, Alfred Wegener, Heike Hoffmann, Uwe Oberheide, Georg Gerten
Based on Helmholtz Theory for accommodation the increasing sclerosis of lens nucleus and cortex is the main cause for the developments of presbyopia. Existing therapies, however, do not reverse the stiffness of the crystalline lens and thus do not regain real accommodation ability. A new approach to restore the flexibility of the lens could be realized by photodisruption using ultrafast laser pulses. This process, known as fs-lentotomy, was used to create micro-incisions which act as gliding planes inside the crystalline lens without opening the eye globe...
June 2010: Journal of Biophotonics
https://www.readbyqxmd.com/read/20108193/-fs-lentotomy-presbyopia-reversal-by-generating-gliding-planes-inside-the-crystalline-lens
#5
H Lubatschowski, S Schumacher, A Wegener, M Fromm, U Oberheide, H Hoffmann, G Gerten
Based on the Helmholtz theory for accommodation, increasing sclerosis of the lens nucleus and cortex is the main cause for the development of presbyopia. Existing therapies, however, do not reverse the stiffness of the crystalline lens and thus do not regain real accommodation ability. A new approach to restore the flexibility of the lens has been realised by utilising the non-linear interaction of ultrafast laser pulses with transparent tissue, the so-called photodisruption. This process has been used to create micro-incisions which act as gliding planes inside the crystalline lens without opening the eye globe...
December 2009: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/19044246/in-vivo-application-and-imaging-of-intralenticular-femtosecond-laser-pulses-for-the-restoration-of-accommodation
#6
Silvia Schumacher, Michael Fromm, Uwe Oberheide, Georg Gerten, Alfred Wegener, Holger Lubatschowski
PURPOSE: According to the Helmholtz theory of accommodation, one major cause of the development of presbyopia is the increasing sclerosis of the crystalline lens. One concept for regaining the elasticity of the sclerosing lens is intralenticular treatment by femtosecond laser pulses. METHODS: The feasibility of applying and imaging in vivo microincisions by femtosecond laser pulses was evaluated in five rabbit lenses with a new high repetition rate (100 kHz) femtosecond laser unit...
November 2008: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/16874535/-in-vitro-and-in-vivo-investigations-on-the-treatment-of-presbyopia-using-femtosecond-lasers
#7
G Gerten, T Ripken, P Breitenfeld, R R Krueger, O Kermani, H Lubatschowski, U Oberheide
BACKGROUND: Ultrashort (femtosecond) laser pulses can generate precise cuts in biological tissue without damaging the surface. The application of femtosecond laser technology at the lens was evaluated with respect to a possible treatment of presbyopia. MATERIALS AND METHODS: Femtosecond laser lentotomy was performed on 150 pig lenses in vitro. Cutting geometry and laser settings were optimized to generate smooth cuts with a minimum of produced gas bubbles. Four rabbit lenses were treated afterwards in vivo and were controlled for 3 months post-treatment...
January 2007: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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