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Keywords Stem cell use in rotator cuff ...

Stem cell use in rotator cuff tears

https://read.qxmd.com/read/38459643/healthy-tendon-stem-cell-derived-exosomes-promote-tendon-to-bone-healing-of-aged-chronic-rotator-cuff-tears-by-breaking-the-positive-feedback-cross-talk-between-senescent-tendon-stem-cells-and-macrophages-through-the-modulation-of-macrophage-polarization
#1
JOURNAL ARTICLE
Xuancheng Zhang, Wei Song, Yang Liu, Kang Han, Yuxu Wu, Eunshinae Cho, Zhaoyi Fang, Lianghua Jiang, Yihe Hu, Xuesong Zhu, Jia Jiang, Xiaoqiao Huangfu, Jinzhong Zhao
The re-tear rate of rotator cuff tears (RCT) after surgical repair is high, especially in aged patients with chronic tears. Senescent tendon stem cells (s-TSCs) generally exist in aged and chronically torn rotator cuff tendons and are closely associated with impaired tendon-to-bone healing results. The present study found a positive feedback cross-talk between s-TSCs and macrophages. The conditioned medium (CM) from s-STCs can promote macrophage polarization mainly toward the M1 phenotype, whose CM reciprocally accelerated further s-TSC senescence...
March 8, 2024: Small
https://read.qxmd.com/read/38411502/optimizing-tissue-engineering-for-clinical-relevance-in-rotator-cuff-repair
#2
JOURNAL ARTICLE
Maxwell Durtschi, Sungwoo Kim, Jiannan Li, Carolyn Kim, Constance Chu, Emilie Cheung, Marc Safran, Geoff Abrams, Yunzhi Peter Yang
Rotator cuff tear (RCT) is the most common cause of disability in the upper-extremity.1 It results in 4.5 million physician visits in the United States every year and is the most common etiology of shoulder conditions evaluated by orthopedic surgeons.2,3 Over 460,000 RCT repair surgeries are performed in the United States annually.4 Rotator cuff (RC) retear and failure to heal remain significant post-operative complications.5 Literature suggests that the retear rates can range from 29.5% to as high as 94%.6,7 Weakened and irregular enthesis regeneration is a crucial factor in post-surgical failure...
February 27, 2024: Tissue Engineering. Part B, Reviews
https://read.qxmd.com/read/38133932/ultrasound-controlled-delivery-of-growth-factor-loaded-cerasomes-combined-with-polycaprolactone-scaffolds-seeded-with-bone-marrow-mesenchymal-stem-cells-for-biomimetic-tendon-to-bone-interface-engineering
#3
JOURNAL ARTICLE
Cancan Du, Ruiqi Wu, Wenqiang Yan, Jingchao Fang, Wenli Dai, Yiqun Wang, Jin Cheng, Xiaoqing Hu, Yingfang Ao, Xiaolong Liang, Zhenlong Liu
Rotator cuff tear (RCT) is a prevalent shoulder injury that poses challenges for achieving continuous and functional regeneration of the tendon-to-bone interface (TBI). In this study, we controlled the delivery of growth factors (GFs) from liposomal nanohybrid cerasomes by ultrasound and implanted three-dimensional printed polycaprolactone (PCL) scaffolds modified with polydopamine loaded with bone marrow mesenchymal stem cells (BMSCs) to repair tears of the infraspinatus tendon in a lapine model. Direct suturing (control, CTL) was used as a control...
December 22, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38115873/mesenchymal-cells-in-rotator-cuff-repair-technique-description-and-case-reports
#4
JOURNAL ARTICLE
Eduardo Angeli Malavolta, Vinicius Lamboglia Miceli, Jorge Henrique Assunção, Fernando Brandao Andrade-Silva, Mauro Emilio Conforto Gracitelli, Nelson Hidekazu Tatsui, Luiz César Espirandelli, Arnaldo Amado Ferreira
OBJECTIVE: To describe a protocol of obtention of mesenchymal stem cells and to report their use as a biological adjuvant in three patients undergoing arthroscopic rotator cuff repair. METHODS: Case series of patients who underwent arthroscopic repair of isolated full-thickness supraspinatus tear using mesenchymal stem cells obtained from the bone marrow as a biological adjuvant. All patients were operated on at the same institution, by a surgeon with 13 years of experience...
2023: Acta Ortopedica Brasileira
https://read.qxmd.com/read/37992858/efficacy-of-transplantation-of-lipoaspired-mesenchymal-stem-cells-in-the-treatment-of-chronic-rotator-cuff-tears-experimental-model-in-rats
#5
JOURNAL ARTICLE
V Ponz-Lueza, Y Lopiz, C Rodríguez-Bobada, P Tornero-Esteban, C Arvinius, C García-Fernández, D Seara-Lifante, F J Rojo-Pérez, F Marco
BACKGROUND AND AIM: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury...
November 20, 2023: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/37984013/platelet-rich-plasma-derived-exosomes-promote-rotator-cuff-tendon-bone-healing
#6
JOURNAL ARTICLE
Lei Han, Ningrui Hu, Canfeng Wang, Zhengcong Ye, Tuo Wang, Fang Lan
BACKGROUND: Rotator cuff tear (RCT) is the most common type of shoulder joint injury, platelet-rich plasma-derived exosomes (PRP-exos) are highly promising in tissue repair and regeneration. The purpose of this study was to determine the function of PRP-exos in rotator cuff tendon-bone healing. METHODS: PRP-exos were isolated from the rabbit whole blood by differential ultracentrifugation and characterized through transmission electron microscopy assay, nanoparticle tracking analysis, and western blotting...
November 14, 2023: Injury
https://read.qxmd.com/read/37981385/editorial-commentary-bone-marrow-stimulation-and%C3%A2-losartan-augmentation-of-shoulder-rotator%C3%A2-cuff%C3%A2-repair
#7
EDITORIAL
Noboru Taniguchi
Rotator cuff retear rates after repair have been variously reported as ranging from 5% to 40% for small to mediums tears and as high as 40% to 94% for large to massive tears. Thus strategies to enhance structural healing are relevant. In rabbits, combining oral losartan (which has antifibrotic effects by downregulating transforming growth factor-β1) and bone marrow stimulation (BMS) of the greater tuberosity, showed improved rotator cuff repair pull-out strength and highly organized tendon matrix in a chronic injury model, whereas BMS alone did not improve the mechanical properties...
December 2023: Arthroscopy
https://read.qxmd.com/read/37979948/age-different-bmscs-derived-exosomes-accelerate-tendon-bone-interface-healing-in-rotator-cuff-tears-model
#8
JOURNAL ARTICLE
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
BACKGROUND: Rotator cuff tears (RCTs) are culprit of shoulder pain and dysfunction. Tendon-bone interface (TBI) mal-healing is an essential contributor to retear after RCTs. Consequently, present project was conducted to investigate the role of bone marrow mesenchymal stem cells (BMSCs)-derived exosomes on TBI healing. METHOD: Young BMSCs (Y-BMSCs) and Aged BMSCs (A-BMSCs) were isolated from Young (3-month-old) and old (24-month-old) SD rats, and their-derived exosomes (A-BMSCs-exo and Y-BMSCs-exo) were identified...
November 16, 2023: Gene
https://read.qxmd.com/read/37898418/the-effect-of-platelet-rich-fibrin-platelet-rich-plasma-and-concentrated-growth-factor-in-the-repair-of-full-thickness-rotator-cuff-tears
#9
JOURNAL ARTICLE
Mert Celikten, Hakan Sahin, Gozde Erkanli Senturk, Kerem Bilsel, Anil Pulatkan, Mehmet Kapicioglu, Bayram Ufuk Sakul
BACKGROUND: Rotator cuff lesions rank among the prevalent causes of shoulder pain. Combining surgical interventions with growth factors, scaffolds, and stem cell therapies can effectively decrease the likelihood of rotator cuff repair recurrence. Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF), isolated from blood and rich in growth factors, have a critical role in cell migration, cell proliferation, and angiogenesis during the tissue regeneration process...
October 26, 2023: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/37879533/interventions-used-to-mitigate-muscle-fatty-degeneration-following-the-repair-of-massive-rotator-cuff-tears-a-systematic-review-of-animal-studies
#10
REVIEW
Dimitrios Stamiris, Athanasios Valasidis, Angeliki Cheva, Kyriakos Papavasiliou, Stavros Stamiris, Michael Potoupnis, Lazaros Poultsidis, Eleftherios Tsiridis, Ioannis Sarris
BACKGROUND: Muscle fatty degeneration following rotator cuff tears has been unequivocally associated with poorer functional outcomes and increased risk for re-tear following rotator cuff repair. Promising results have emerged from animal studies, with the implementation of various interventions for biologic inhibition of this fatty muscle degeneration. The lack of high quality randomized human evidence on this topic, increases the impact of pooled results from animal literature. The aim of the present study was to systematically review the available published literature for animal studies evaluating the ability of several interventions used to mitigate muscle fatty degeneration following the repair of massive rotator cuff tears...
October 23, 2023: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/37719828/clinical-outcomes-of-rotator-cuff-repair-with-subacromial-bursa-reimplantation-a-retrospective-cohort-study
#11
JOURNAL ARTICLE
James M Gregory, Cristian Ybarra, Zean Liao, Manickam Kumaravel, Saagar Patel, Ryan J Warth
BACKGROUND: The subacromial bursa has been found to be a rich, local, source of mesenchymal stem cells but is removed for visualization during rotator cuff repair. Reimplantation of this tissue may improve rotator cuff healing. The purpose of this study is to evaluate clinical outcomes of rotator cuff repair with and without subacromial bursa reimplantation. METHODS: Patients aged 37-77 with a full-thickness or near full-thickness supraspinatus tears underwent arthroscopic transosseous-equivalent double row rotator cuff repair...
September 2023: JSES international
https://read.qxmd.com/read/37592455/assessment-of-a-synergistic-effect-of-platelet-rich-plasma-and-stem-cell-seeded-hydrogel-for-healing-of-rat-chronic-rotator-cuff-injuries
#12
JOURNAL ARTICLE
Hiroki Oda, Yukitoshi Kaizawa, Austin Franklin, Uriel Sanchez Rangel, Hunter Storaci, Jung Gi Min, Zhen Wang, Geoffrey D Abrams, James Chang, Paige M Fox
Outcomes after repair of chronic rotator cuff injuries remain suboptimal. Type-1 collagen-rich tendon hydrogel was previously reported to improve healing in a rat chronic rotator cuff injury model. Stem cell seeding of the tendon hydrogel improved bone quality in the same model. This study aimed to examine whether there was a synergistic and dose-dependent effect of platelet-rich plasma (PRP) on tendon-bone interface healing by combining PRP with stem cell-seeded tendon hydrogel. Human cadaveric tendons were processed into a hydrogel...
2023: Cell Transplantation
https://read.qxmd.com/read/37560389/development-of-a-novel-animal-model-of-rotator-cuff-tear-arthropathy-replicating-clinical-features-of-progressive-osteoarthritis-with-subchondral-bone-collapse
#13
JOURNAL ARTICLE
T Ijuin, T Iuchi, H Tawaratsumida, Y Masuda, A Tokushige, S Maeda, N Taniguchi
OBJECTIVE: To establish an animal model of modified cuff tear arthropathy (mCTA) in order to better replicate the pathophysiology associated with rotator cuff tear-induced humeral head collapse. DESIGN: mCTA was induced by transection of the rotator cuff, the long head of the biceps brachii (LHB), and superior half of the joint capsule in the right shoulder of 12-week-old rats; the left shoulder underwent sham surgery. The severity of CTA was quantitated using the Murine Shoulder Arthritis Score (MSAS)...
September 2023: Osteoarthritis and cartilage open
https://read.qxmd.com/read/37421180/secretome-of-hypoxia-preconditioned-mesenchymal-stem-cells-enhance-the-expression-of-hif-1a-and-bfgf-in-a-rotator-cuff-tear-model
#14
JOURNAL ARTICLE
Meiky Fredianto, Herry Herman, Yoyos Dias Ismiarto, Agung Putra, Iffan Alif, Nur Dina Amalina, Muhammad Ariq Nazar
Aim To determine the effect of secretome hypoxia mesenchymal stem cells (SH-MSCs) on the relative gene expression of hypoxia inducible factor-1a (HIF-1a) and basic fibroblast growth factor (bFGF) in accelerating histomorphometric repair of tendon to bone interface healing in rats acute rotator cuff tear (RCT) model. Methods This is experimental research with posttest control group design. Thirty-male Wistar rats were divided into five treatment groups: healthy group and rotator cuff reconstruction group included four groups: SH-MSCs W2 (the treatment group was given a SH-MSCs 0...
August 1, 2023: Medicinski Glasnik
https://read.qxmd.com/read/37230410/efficacy-of-transplantation-of-lipoaspired-mesenchymal-stem-cells-in-the-treatment-of-chronic-rotator-cuff-tears-experimental-model-in-rats
#15
JOURNAL ARTICLE
Virginia Ponz-Lueza, Yaiza Lopiz, Cruz Rodríguez-Bobada, Pilar Tornero-Esteban, Camila Arvinius, Carlos García-Fernández, Damian Seara-Lifante, Fracisco J Rojo-Pérez, Fernando Marco
BACKGROUND AND AIM: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury...
May 23, 2023: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/36917828/exosomes-derived-from-kartogenin-preconditioned-mesenchymal-stem-cells-promote-cartilage-formation-and-collagen-maturation-for-enthesis-regeneration-in-a-rat-model-of-chronic-rotator-cuff-tear
#16
JOURNAL ARTICLE
Jiangyu Cai, Junjie Xu, Zipeng Ye, Liren Wang, Ting Zheng, Tianlun Zhang, Yufeng Li, Jia Jiang, Jinzhong Zhao
BACKGROUND: Poor tendon-to-bone healing in chronic rotator cuff tears (RCTs) is related to unsatisfactory outcomes. Exosomes derived from mesenchymal stem cells reportedly enhance rotator cuff healing. However, the difficulty in producing exosomes with a stronger effect on enthesis regeneration must be resolved. PURPOSE: To study the effect of exosomes derived from kartogenin (KGN)-preconditioned human bone marrow mesenchymal stem cells (KGN-Exos) on tendon-to-bone healing in a rat model of chronic RCT...
April 2023: American Journal of Sports Medicine
https://read.qxmd.com/read/36684112/tissue-engineered-tendon-nano-constructs-for-repair-of-chronic-rotator-cuff-tears-in-large-animal-models
#17
JOURNAL ARTICLE
Yonghyun Gwon, Woochan Kim, Sunho Park, Yang-Kyung Kim, Hyoseong Kim, Myung-Sun Kim, Jangho Kim
Chronic rotator cuff tears (RCTs) are one of the most common injuries of shoulder pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically repaired rotator cuffs (RCs), complete functional recovery-without retear-of the RC tendon through tendon-to-bone interface (TBI) regeneration remains a key clinical goal to be achieved. Inspired by the highly organized nanostructured extracellular matrix in RC tendon tissue, we propose herein a tissue-engineered tendon nano-construct (TNC) for RC tendon regeneration...
January 2023: Bioengineering & Translational Medicine
https://read.qxmd.com/read/36481477/tgf-%C3%AE-1-stimulated-mesenchymal-stem-cells-generated-exosomal-mir-29a-promotes-the-proliferation-migration-and-fibrogenesis-of-tenocytes-by-targeting-fabp3
#18
JOURNAL ARTICLE
Jia Li, Zhi-Hui Wang, Yu-Hang Sun
BACKGROUND: Rotator cuff Tear (RCT) causes a lot of inconvenience for patients. In most cases, RCT injury does not heal back to bone after repair, and there is a high chance of retearing. Therefore, there is a need to explore more effective targeted therapies. Bone mesenchymal stem cell-derived exosome (BMSCs-Exo) has been proved to be beneficial to the proliferation of tendon cells, but its specific mechanism remains to be further explored. METHODS: BMSCs-Exo was isolated and identified by detecting the specific markers using flow cytometry and western blot assays...
December 5, 2022: Cytokine
https://read.qxmd.com/read/36375873/augmentation-of-arthroscopic-rotator-cuff-repair-biologics-and-grafts
#19
REVIEW
Caleb N Morgan, Kevin F Bonner, Justin W Griffin
Arthroscopic augmentation of massive and irreparable rotator cuff tears proves to be a valid and evidence-based treatment option to maximize healing and patient outcomes following rotator cuff repair. Integration of acellular dermal allografts as augment or interposition grafts demonstrates definitive benefit in patients with high risk of retear or individuals with severely retracted tears, respectively. Furthermore, these allografts have demonstrated benefit when used for superior capsular repair for chronic, atrophied tears in young, active patients who do not want to proceed with a reverse total shoulder replacement...
January 2023: Clinics in Sports Medicine
https://read.qxmd.com/read/36090820/clinical-perspectives-for-repairing-rotator-cuff-injuries-with-multi-tissue-regenerative-approaches
#20
REVIEW
Xu Zhang, Dan Wang, Zuyong Wang, Samuel Ka-Kin Ling, Patrick Shu-Hang Yung, Rocky S Tuan, Dai Fei Elmer Ker
Background: In the musculoskeletal system, bone, tendon, and muscle form highly integrated multi-tissue units such as the rotator cuff complex, which facilitates functional and dynamic movement of the shoulder joint. Understanding the intricate interplay among these tissues within clinical, biological, and engineering contexts is vital for addressing challenging issues in treatment of musculoskeletal disorders and injuries. Methods: A wide-ranging literature search was performed, and findings related to the socioeconomic impact of rotator cuff tears, the structure-function relationship of rotator cuff bone-tendon-muscle units, pathophysiology of injury, current clinical treatments, recent state-of-the-art advances (stem cells, growth factors, and exosomes) as well as their regulatory approval, and future strategies aimed at engineering bone-tendon-muscle musculoskeletal units are outlined...
September 2022: Journal of Orthopaedic Translation
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