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Sirtuin3

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https://www.readbyqxmd.com/read/29238464/curcumin-enhances-liver-sirt3-expression-in-the-rat-model-of-cirrhosis
#1
Sara Chenari, Fatemeh Safari, Ali Moradi
Objectives: Bill duct ligation (BDL) is a representative model of biliary cholestasis in animals. Curcumin has a protective effect on the liver; however, its underlying mechanisms are not completely known. This study explored the hepatoprotective activity of curcumin on hepatic damage via measuring the expression of sirtuin3 (SIRT3), AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase 1A (CPT-1A), isocitrate dehydrogenase2 (IDH2) and manganese superoxide dismutase (MnSOD) as well as the level of serum lipid profile in the BDL fibrotic rat model...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28965081/sirt1-sirt3-axis-regulates-human-blood-brain-barrier-permeability-in-response-to-ischemia
#2
Tao Chen, Shu-Hui Dai, Xia Li, Peng Luo, Jie Zhu, Yu-Hai Wang, Zhou Fei, Xiao-Fan Jiang
Sirtuin1 (Sirt1) and Sirtuin3 (Sirt3) are two well-characterized members of the silent information regulator 2 (Sir2) family of proteins. Both Sirt1 and Sirt3 have been shown to play vital roles in resistance to cellular stress, but the interaction between these two sirtuins has not been fully determined. In this study, we investigated the role of Sirt1-Sirt3 axis in blood-brain barrier (BBB) permeability after ischemia in vitro. Human brain microvascular endothelial cells and astrocytes were co-cultured to model the BBB in vitro and oxygen and glucose deprivation (OGD) was performed to mimic ischemia...
September 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/28760678/sirt3-inhibits-ang-ii-induced-transdifferentiation-of-cardiac-fibroblasts-through-%C3%AE-catenin-ppar-%C3%AE-signaling
#3
Xiaobin Guo, Fangying Yan, Xiaolan Shan, Jingyuan Li, Yi Yang, Jie Zhang, Xuefang Yan, Peili Bu
AIMS: Cardiac fibrosis is an inevitable process of numerous cardiovascular diseases in which the transdifferentiation of cardiac fibroblasts plays a pivotal role. Sirtuin3 (SIRT3) has been believed to protect against cardiac fibrosis. However, the mechanism underlying this beneficial effect has not yet been elucidated. In this study, we investigated the potential mechanism of SIRT3 on the inhibition of fibroblast-to-myoblast transdifferentiation. MAIN METHODS: Cells were stimulated by angiotension II (Ang II) with SIRT3 overexpression or knockdown...
October 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28526626/longevity-and-healthy-ageing-genes-foxo3a-and-sirt3-serum-protein-marker-and-new-road-map-to-burst-oxidative-stress-by-withania-somnifera
#4
Rashmita Pradhan, Rahul Kumar, Shashank Shekhar, Nitish Rai, Akash Ambashtha, Joyita Banerjee, Mona Pathak, S N Dwivedi, Sharmistha Dey, Aparajit B Dey
BACKGROUND: Ageing process is characterized by a decline in function; different age related diseases and excessive age associated mortality. There has always been a quest for easily accessible biomarkers to monitor and identify the development of age-associated stress for providing new anti-ageing strategies. Forkhead box protein O3A (FOXO3A) and Sirtuin3 (SIRT3) are such potential markers which plays important role in a wide variety of cellular mechanisms and has been proposed to be an ideal candidate to study longevity and are potential candidate for healthy ageing by oxidative burst...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28396174/sirt3-confers-protection-against-neuronal-ischemia-by-inducing-autophagy-involvement-of-the-ampk-mtor-pathway
#5
Shu-Hui Dai, Tao Chen, Xia Li, Kang-Yi Yue, Peng Luo, Li-Kun Yang, Jie Zhu, Yu-Hai Wang, Zhou Fei, Xiao-Fan Jiang
Sirtuin3 (Sirt3) is a member of the silent information regulator 2 (Sir2) family of proteins located in mitochondria that influences almost every major aspect of mitochondrial biology, including ATP generation and reactive oxygen species (ROS) production. Our previous study showed that Sirt3 exerts protective effects against oxidative stress in neuronal cells. In this study, we investigated the role of Sirt3 in neuronal ischemia using an oxygen and glucose deprivation (OGD) model. Sirt3 was up-regulated by OGD and overexpression of Sirt3 through lentivirus transfection significantly reduced OGD-induced lactate dehydrogenase (LDH) release and neuronal apoptosis...
April 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28073422/-research-advances-in-the-association-between-deacetylase-sirtuin3-and-liver-diseases
#6
REVIEW
J Yu, C Chen, W X Wang
The deacetylase Sirtuin 3 (SIRT3) is a member of the Sirtuins mainly located in the mitochondrial matrix, and as a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, it can regulate cellular energy metabolism and oxidative stress-related pathways. The liver is the largest solid organ in the human body and plays a very important role in substance metabolism. Based on the features of SIRT3, it is closely associated with the development and progression of certain liver diseases. This article reviews the research advances in the role of SIRT3 in non-alcoholic fatty liver disease, liver cancer, and hepatic ischemia-reperfusion injury...
December 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27888691/redox-imbalance-and-mitochondrial-abnormalities-in-the-diabetic-lung
#7
Jinzi Wu, Zhen Jin, Liang-Jun Yan
Although the lung is one of the least studied organs in diabetes, increasing evidence indicates that it is an inevitable target of diabetic complications. Nevertheless, the underlying biochemical mechanisms of lung injury in diabetes remain largely unexplored. Given that redox imbalance, oxidative stress, and mitochondrial dysfunction have been implicated in diabetic tissue injury, we set out to investigate mechanisms of lung injury in diabetes. The objective of this study was to evaluate NADH/NAD(+) redox status, oxidative stress, and mitochondrial abnormalities in the diabetic lung...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/27773814/role-of-sirtuin3-in-high-glucose-induced-apoptosis-in-renal-tubular-epithelial-cells
#8
Xiaocui Jiao, Ying Li, Tao Zhang, Maodong Liu, Yanqing Chi
The apoptosis of renal tubular epithelial cells contributes to the pathogenesis of diabetic nephropathy. High glucose-induced mitochondrial oxidative stress is considered to be an important mediator for renal tubular cell apoptosis. Sirtuin3(Sirt3), a kind of mitochondria-localized nicotinamide adenine dinucleotide(NAD(+))-dependent protein deacetylase, has been reported to regulate the generation of ROS in mitochondria through regulating acetylation level and activity of several key mitochondrial enzymes. In this study, we investigated the role of Sirt3 on high glucose-induced apoptosis in HK-2 cells...
November 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27246217/cloning-and-characterization-of-sirtuin3-sirt3
#9
Andy W C Man, Bo Bai, Yu Wang
Mitochondria play a pivotal role in maintaining cellular homeostasis and regulating longevity. SIRT3 is a mitochondrial sirtuin mediating the deacetylation of various metabolic and antioxidant enzymes, in turn controlling energy metabolism, stress resistance, and the pace of ageing. To study the function of SIRT3, a proteomics-based approach is employed for identifying the protein-binding partners of this enzyme in mitochondria.
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26950437/protective-role-of-sirtuin3-sirt3-in-oxidative-stress-mediated-by-hepatitis-b-virus-x-protein-expression
#10
Ji-Hua Ren, Xiang Chen, Li Zhou, Na-Na Tao, Hong-Zhong Zhou, Bo Liu, Wan-Yu Li, Ai-Long Huang, Juan Chen
BACKGROUND/AIM: The hepatitis B virus (HBV) infection is accompanied by the induction of oxidative stress, especially mediated by HBV X protein (HBx). Oxidative stress has been implicated in a series of pathological states, such as DNA damage, cell survival and apoptosis. However, the host factor by which cells protect themselves under this oxidative stress is poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we first confirmed that HBV infection significantly induced oxidative stress...
2016: PloS One
https://www.readbyqxmd.com/read/26905378/exercise-mitigates-mitochondrial-permeability-transition-pore-and-quality-control-mechanisms-alterations-in-nonalcoholic-steatohepatitis
#11
Inês O Gonçalves, Emanuel Passos, Cátia V Diogo, Sílvia Rocha-Rodrigues, Estela Santos-Alves, Paulo J Oliveira, António Ascensão, José Magalhães
Mitochondrial quality control and apoptosis have been described as key components in the pathogenesis of nonalcoholic steatohepatitis (NASH); exercise is recognized as a nonpharmacological strategy to counteract NASH-associated consequences. We aimed to analyze the effect of voluntary physical activity (VPA) and endurance training (ET) against NASH-induced mitochondrial permeability transition pore (mPTP) opening and mitochondrial and cellular quality control deleterious alterations. Forty-eight male Sprague-Dawley rats were divided into standard-diet sedentary (SS, n = 16), standard-diet VPA (n = 8), high-fat diet sedentary (HS, n = 16), and high-fat diet VPA (n = 8)...
March 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/26666995/liraglutide-ameliorates-non-alcoholic-fatty-liver-disease-by-enhancing-mitochondrial-architecture-and-promoting-autophagy-through-the-sirt1-sirt3-foxo3a-pathway
#12
Wenxin Tong, Liping Ju, Miaoyan Qiu, Qihai Xie, Ying Chen, Weili Shen, Weihong Sun, Weiqing Wang, Jingyan Tian
AIM: Overwhelming oxidative stress is implicated as crucial in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Liraglutide, a well-established antidiabetes drug, was recently reported to ameliorate NAFLD with an elusive mechanism. We used a mouse model to examine whether liraglutide could ameliorate NAFLD and explored the possible mechanisms. METHODS: Twenty C57BL/6J mice were randomly treated with a normal-fat diet or high-fat diet for 16 weeks, then further distributed into four groups and subjected to s...
August 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26422756/sirt3-mediates-the-antioxidant-effect-of-hydrogen-sulfide-in-endothelial-cells
#13
Liping Xie, Haihua Feng, Sha Li, Guoliang Meng, Shangmin Liu, Xin Tang, Yan Ma, Yi Han, Yujiao Xiao, Yue Gu, Yongfeng Shao, Chung-Min Park, Ming Xian, Yu Huang, Albert Ferro, Rui Wang, Philip K Moore, Hong Wang, Yong Ji
AIM: Oxidative stress is a key contributor to endothelial dysfunction and associated cardiovascular pathogenesis. Hydrogen sulfide (H2S) is an antioxidant gasotransmitter that protects endothelial cells against oxidative stress. Sirtuin3 (SIRT3), which belongs to the silent information regulator 2 (SIR2) family, is an important deacetylase under oxidative stress. H2S is able to regulate the activity of several sirtuins. The present study aims to investigate the role of SIRT3 in the antioxidant effect of H2S in endothelial cells...
February 20, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/25993470/sirtuin3-dysfunction-is-the-key-determinant-of-skeletal-muscle-insulin-resistance-by-angiotensin-ii
#14
Daniela Macconi, Luca Perico, Lorena Longaretti, Marina Morigi, Paola Cassis, Simona Buelli, Norberto Perico, Giuseppe Remuzzi, Ariela Benigni
BACKGROUND: Angiotensin II promotes insulin resistance. The mechanism underlying this abnormality, however, is still poorly defined. In a different setting, skeletal muscle metabolism and insulin signaling are regulated by Sirtuin3. OBJECTIVE: Here, we investigate whether angiotensin II-induced insulin resistance in skeletal muscle is associated with Sirtuin3 dysregulation and whether pharmacological manipulation of Sirtuin3 confers protection. STUDY DESIGN: Parental and GLUT4-myc L6 rat skeletal muscle cells exposed to angiotensin II are used as in vitro models of insulin resistance...
2015: PloS One
https://www.readbyqxmd.com/read/25961022/-2-1-3-methoxycarbonylmethyl-1h-indol-2-yl-1-methyl-ethyl-1h-indol-3-yl-acetic-acid-methyl-ester-inhibited-hepatocellular-carcinoma-growth-in-bel-7402-cells-and-its-resistant-variants-by-activation-of-nox4-and-sirt3
#15
Ye Li, Wenjing Wang, Xiaoxue Xu, Shiyue Sun, Xiaoyu Xu, Xian-jun Qu
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM) is a novel indole compound, which possessed high efficacy against many cancers xenografted in mice without obvious toxicity. In this study, we aimed to investigate the effects of MIAM on human hepatocellular carcinoma (HCC) Bel-7402 cells and its resistant variants Bel-7402/5FU. MIAM inhibited the growth of HCC more potent in Bel-7402/5FU cells than its parent cells. MIAM increased cellular reactive oxygen species (ROS) levels, induced cell apoptosis, and arrested cell cycle in G0/G1 phase...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25902914/oroxylin-a-promotes-pten-mediated-negative-regulation-of-mdm2-transcription-via-sirt3-mediated-deacetylation-to-stabilize-p53-and-inhibit-glycolysis-in-wt-p53-cancer-cells
#16
Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu, Libin Wei
INTRODUCTION: p53 plays important roles in regulating the metabolic reprogramming of cancer, such as aerobic glycolysis. Oroxylin A is a natural active flavonoid with strong anticancer effects both in vitro and in vivo. METHODS: wt-p53 (MCF-7 and HCT116 cells) cancer cells and p53-null H1299 cancer cells were used. The glucose uptake and lactate production were analyzed using Lactic Acid production Detection kit and the Amplex Red Glucose Assay Kit. Then, the protein levels and RNA levels of p53, mouse double minute 2 (MDM2), and p53-targeted glycolytic enzymes were quantified using Western blotting and quantitative polymerase chain reaction (PCR), respectively...
April 23, 2015: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/25877446/losartan-protects-the-heart-against-ischemia-reperfusion-injury-sirtuin3-involvement
#17
Mohsen Sharifi Klishadi, Farideh Zarei, Seyyed Hassan Hejazian, Ali Moradi, Mahdieh Hemati, Fatemeh Safari
PURPOSE: Sirtuin-3 (SIRT3) deacetylase protects the heart against oxidative stress via survival factors upregulation. Clinical and experimental studies have demonstrated that activation of systemic and local renin-angiotensin system (RAS) is implicated in ischemia-induced cardiac injury. However, the relation between RAS and SIRT3 in pathophysiology of myocardial ischemia reperfusion is unknown. In this study, the cardiac transcription and expression of SIRT3 levels was examined in response to ischemia reperfusion in untreated and losartan treated rats...
2015: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25555707/sirt3-attenuates-mptp-induced-nigrostriatal-degeneration-via-enhancing-mitochondrial-antioxidant-capacity
#18
Lei Liu, Carina Peritore, Jessica Ginsberg, Merve Kayhan, Gizem Donmez
Parkinson's disease (PD) is one of the most common neurodegenerative diseases, which is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. There is a growing consensus that mitochondrial dysfunction and oxidative stress play a crucial role in PD pathogenesis. Sirtuin3 (SIRT3) is the major mitochondria NAD(+)-dependent deacetylase that acts as a regulator of mitochondrial protein function; it is essential for maintaining mitochondrial integrity. Although SIRT3 was reported to have anti-oxidative stress activity in an in vitro study, there is no explicit in vivo evidence for the involvement of SIRT3 in the etiology of PD...
March 2015: Neurochemical Research
https://www.readbyqxmd.com/read/25210848/decreased-sirt3-in-aged-human-mesenchymal-stromal-stem-cells-increases-cellular-susceptibility-to-oxidative-stress
#19
Xue-Qing Wang, Yong Shao, Chong-Yi Ma, Wei Chen, Lu Sun, Wei Liu, Dong-Yang Zhang, Bi-Cheng Fu, Kai-Yu Liu, Zhi-Bo Jia, Bao-Dong Xie, Shu-Lin Jiang, Ren-Ke Li, Hai Tian
Sirtuin3 (SIRT3) is an important member of the sirtuin family of protein deacetylases that is localized to mitochondria and linked to lifespan extension in organisms ranging from yeast to humans. As aged cells have less regenerative capacity and are more susceptible to oxidative stress, we investigated the effect of ageing on SIRT3 levels and its correlation with antioxidant enzyme activities. Here, we show that severe oxidative stress reduces SIRT3 levels in young human mesenchymal stromal/stem cells (hMSCs)...
November 2014: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/24464007/lithium-and-valproate-acid-protect-nsc34-cells-from-h2o2-induced-oxidative-stress-and-upregulate-expressions-of-sirt3-and-carm1
#20
Jing Wang, Honglin Feng, Jun Zhang, Hongquan Jiang
OBJECTIVE: Lithium and valproic acid (VPA) have been reported to produce antioxidant effects by increasing the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) expression, which may contribute to their neuroprotective properties. As a coactivator for many transcriptional factors including PGC-1α, coactivator-associated arginine methyltransferase1(CARM1) regulates oxidative metabolism and mitochondrial biogenesis. Besides, Sirtuin3 (SIRT3), a new target of PGC-1α, plays an important role in preserving mitochondrial function...
2013: Neuro Endocrinology Letters
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