D Martin, F Rödel, S Hehlgans, M Looso, P K Ziegler, M Fleischmann, M Diefenhardt, L Fries, G Kalinauskaite, I Tinhofer, D Zips, C Gani, C Rödel, E Fokas
Anal squamous cell carcinoma (ASCC) is associated with immunosuppression and infection with human papillomavirus (HPV). Response to standard chemoradiotherapy (CRT) varies considerably. A comprehensive molecular characterization of CRT resistance is lacking, and little is known about the interplay between tumor immune contexture, host immunity, and immunosuppressive and/or immune activating effects of CRT. Patients with localized ASCC, treated with CRT at three different sites of the German Cancer Consortium (DKTK) were included...
April 23, 2024: NPJ Precision Oncology