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Extra-cardiac circulation

Rodrigo Antonio Peliciari-Garcia, Rafael Maso Prévide, Maria Tereza Nunes, Martin Elliot Young
Triiodothyronine (T3) is an important modulator of cardiac metabolism and function, often through modulation of gene expression. The cardiomyocyte circadian clock is a transcriptionally based molecular mechanism capable of regulating cardiac processes, in part by modulating responsiveness of the heart to extra-cardiac stimuli/stresses in a time-of-day (TOD)-dependent manner. Although TOD-dependent oscillations in circulating levels of T3 (and its intermediates) have been established, oscillations in T3 sensitivity in the heart is unknown...
September 23, 2016: Chronobiology International
S Birch, D Casamian-Sorrosal, S Fonfara, G Chanoit, C Warren-Smith
This case report describes a combination of congenital cardiopulmonary abnormalities found in a 1-year-old Labrador Retriever. To the authors' knowledge this combination of cardiopulmonary abnormalities has not been previously reported in veterinary medicine. Unilateral absence of the right pulmonary artery associated with unilateral right-sided aortopulmonary collaterals was observed. These aortopulmonary collaterals preserved the blood supply to the right lung lobes but led to left ventricular volume overload...
September 7, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Mariann Tang, Per Wierup, Catherine J Rea, Jrgen Ingerslev, Vibeke E Hjortdal, Benny Srensen
Cardiac surgery induces a multifactorial coagulopathy. Regular use of tranexamic acid (TXA) is becoming standard of care. Clinical challenges include selecting optimal dosing regimen and balancing the benefit versus risk of additional dosing with antifibrinolytics. The objective was to evaluate the effect of TXA by assessing kinetic properties of plasma clot formation, clot stability, and clot fibrinolysis. The study was a prospective case follow-up of 28 patients undergoing cardiac surgery (mean age 63.9 years, 29% women)...
September 2, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Jung-Heun Ha, Caglar Doguer, Xiaoyu Wang, Shireen R Flores, James F Collins
Iron-copper interactions were described decades ago; however, molecular mechanisms linking the two essential minerals remain largely undefined. Investigations in humans and other mammals noted that copper levels increase in the intestinal mucosa, liver and blood during iron deficiency, tissues all important for iron homeostasis. The current study was undertaken to test the hypothesis that dietary copper influences iron homeostasis during iron deficiency and iron overload. We thus fed weanling, male Sprague-Dawley rats (n = 6-11/group) AIN-93G-based diets containing high (~8800 ppm), adequate (~80) or low (~11) iron in combination with high (~183), adequate (~8) or low (~0...
2016: PloS One
N C McAvoy, S Semple, J M J Richards, A J Robson, D Patel, A G M Jardine, K Leyland, A S Cooper, D E Newby, P C Hayes
BACKGROUND: With advancing liver disease and the development of portal hypertension, there are major alterations in somatic and visceral blood flow. Using phase-contrast magnetic resonance angiography, we characterised alterations in blood flow within the hepatic, splanchnic and extra-splanchnic circulations of patients with established liver cirrhosis. AIM: To compare blood flow in splanchnic and extra-splanchnic circulations in patients with varying degrees of cirrhosis and healthy controls...
May 2016: Alimentary Pharmacology & Therapeutics
Kyriakos Anastasiadis, John Murkin, Polychronis Antonitsis, Adrian Bauer, Marco Ranucci, Erich Gygax, Jan Schaarschmidt, Yves Fromes, Alois Philipp, Balthasar Eberle, Prakash Punjabi, Helena Argiriadou, Alexander Kadner, Hansjoerg Jenni, Guenter Albrecht, Wim van Boven, Andreas Liebold, Fillip de Somer, Harald Hausmann, Apostolos Deliopoulos, Aschraf El-Essawi, Valerio Mazzei, Fausto Biancari, Adam Fernandez, Patrick Weerwind, Thomas Puehler, Cyril Serrick, Frans Waanders, Serdar Gunaydin, Sunil Ohri, Jan Gummert, Gianni Angelini, Volkmar Falk, Thierry Carrel
Minimal invasive extracorporeal circulation (MiECC) systems have initiated important efforts within science and technology to further improve the biocompatibility of cardiopulmonary bypass components to minimize the adverse effects and improve end-organ protection. The Minimal invasive Extra-Corporeal Technologies international Society was founded to create an international forum for the exchange of ideas on clinical application and research of minimal invasive extracorporeal circulation technology. The present work is a consensus document developed to standardize the terminology and the definition of minimal invasive extracorporeal circulation technology as well as to provide recommendations for the clinical practice...
May 2016: Interactive Cardiovascular and Thoracic Surgery
Dennis Madden, Stephen R Thom, Zeljko Dujic
Risk in SCUBA diving is often associated with the presence of gas bubbles in the venous circulation formed during decompression. Although it has been demonstrated time-after-time that, while venous gas emboli (VGE) often accompany decompression sickness (DCS), they are also frequently observed in high quantities in asymptomatic divers following even mild recreational dive profiles. Despite this VGE are commonly utilized as a quantifiable marker of the potential for an individual to develop DCS. Certain interventions such as exercise, antioxidant supplements, vibration, and hydration appear to impact VGE production and the decompression process...
January 2016: Medical Hypotheses
Ilaria Cavazzana, Micaela Fredi, Carlo Selmi, Angela Tincani, Franco Franceschini
Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of myositis, characterised by chronic muscle weakness, cutaneous features, different extra-muscular manifestations and circulating autoantibodies. IIMs included classical polymyositis (PM), dermatomyositis (DM) and other different types of myositis with a wide range of muscle involvement. A complete autoantibody profile and a muscle biopsy are mandatory to correctly diagnose different clinical entities and to define their different prognosis...
October 29, 2015: Clinical Reviews in Allergy & Immunology
Ameeta Yaksh, Lisette J M E van der Does, Charles Kik, Paul Knops, Frans B S Oei, Pieter C van de Woestijne, Jos A Bekkers, Ad J J C Bogers, Maurits A Allessie, Natasja M S de Groot
PURPOSE: A new technique is demonstrated for extensive high-resolution intra-operative atrial mapping that will facilitate the localization of atrial fibrillation (AF) sources and identification of the substrate perpetuating AF. METHODS: Prior to the start of extra-corporal circulation, a 8 × 24-electrode array (2-mm inter-electrode distance) is placed subsequently on all the right and left epicardial atrial sites, including Bachmann's bundle, for recording of unipolar electrograms during sinus rhythm and (induced) AF...
December 2015: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Masaki Kohno, Yusuke Nagamine, Takahisa Goto
We experienced a case of undiagnosed extra-adrenal pheochromocytoma in an adult patient with single ventricle circulation after the bidirectional Glenn operation. A 32-year-old woman was scheduled for open abdominal surgery for incidental retroperitoneal tumor. She had undergone the bidirectional Glenn operation for complex congenital heart disease consisting of double outlet right ventricle, ventricular septal defect, and pulmonary artery stenosis. She had not undergone the Fontan operation because of insufficient development of pulmonary circulation...
September 2015: Masui. the Japanese Journal of Anesthesiology
Kenji Yoshitani, Yoshihiko Ohnishi
Regional cerebral oxygen saturation measured by near-infrared spectroscopy has been used clinically. Its usefulness in cardiac surgery and neurosurgery was also reported. On the other hand, accuracy of rSO2 values has been supposed to be doubtful due to extra-cerebral contamination and unstable mean optical path-length. Therefore, we tried to review issues for accuracy of rSO2 values and clinical usefulness. Our aim is to clarify the issue and clinical usefulness of measuring regional cerebral oxygen saturation...
May 2015: Masui. the Japanese Journal of Anesthesiology
Alessandro Varrica, Angela Satriano, Alessandro Frigiola, Alessandro Giamberti, Guido Tettamanti, Luigi Anastasia, Erika Conforti, Antonio D W Gavilanes, Luc J Zimmermann, Hans J S Vles, Giovanni Li Volti, Diego Gazzolo
BACKGROUND: S100B protein, previously proposed as a consolidated marker of brain damage in congenital heart disease (CHD) newborns who underwent cardiac surgery and cardiopulmonary bypass (CPB), has been progressively abandoned due to S100B CNS extra-source such as adipose tissue. The present study investigated CHD newborns, if adipose tissue contributes significantly to S100B serum levels. METHODS: We conducted a prospective study in 26 CHD infants, without preexisting neurological disorders, who underwent cardiac surgery and CPB in whom blood samples for S100B and adiponectin (ADN) measurement were drawn at five perioperative time-points...
2015: BioMed Research International
Makoto Hibiya, Tetsuya Kamei, Kiyoshi Yoshida, Shoji Kubota, Hiroya Kano, Tomohiro Nakamura, Saori Ishida, Chihiro Saito, Kyoichi Kemmoku
The International Consortium for Evidence-Based Perfusion (ICEBP) is a collaborative group whose mission is to improve, continuously, the delivery of care and outcomes for patients undergoing cardiac surgery. To achieve this end, the ICEBP supports the development of perfusion registries to evaluate clinical practices and has established evidence-based guidelines for perfusion. The Japanese Society of Extra-Corporeal Technology in Medicine (JaSECT) developed a perfusion registry to examine variation in perfusion practice in Japan...
September 2014: Journal of Extra-corporeal Technology
Jignesh K Patel, Vikram Chabra, Sam Parnia
PURPOSE OF REVIEW: To provide a summary of the recent literature on clinical outcomes in adults with cardiac arrest, focusing on the impact of patient-specific factors in combination with cardio-pulmonary resuscitation (CPR) related, and postresuscitative-related factors. RECENT FINDINGS: Cardiac arrest is a major cause of morbidity and mortality worldwide. Despite the use of conventional cardiopulmonary resuscitation, rates of return of spontaneous circulation and survival with minimal neurologic impairment remain low...
October 2015: Current Opinion in Critical Care
Sayqa Arif, Paul F Clift, Joseph V De Giovanni
AIMS: In patients with an extra-cardiac Fontan circulation, there is no direct access to the heart. The insertion of a permanent pacemaker requires surgery to insert epicardial pacing wires. We present the implantation of a permanent endocardial pacing lead from the superior vena cava (SVC) into the atrium via direct passage from the right pulmonary artery (RPA). METHODS AND RESULTS: A permanent pacing lead was passed directly from the SVC to the RPA and then into the atrial mass...
February 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Igor Balevski, Andrej Markota, Darinka Purg, Matej Bernhardt, Matej Strnad, Vojko Kanič, Andreja Sinkovič
In patients with refractory cardiac arrest presumably from acute coronary occlusion, primary percutaneous coronary intervention (PPCI) may provide an opportunity for revascularisation and, subsequently, return of spontaneous circulation. We present our experience from a 24/7 primary percutaneous coronary intervention centre serving a population of approximately 800,000 individuals. A retrospective analysis was performed in patients with cardiac arrest treated from July 2011 to January 2014. Inclusion criteria were cardiac arrest and emergency coronary angiography performed during on-going external cardiopulmonary resuscitation (CPR)...
December 2015: Wiener Klinische Wochenschrift
Kersti K Linask, Mingda Han, Nathalie J M Bravo-Valenzuela
Analyses of cardiovascular development have shown an important interplay between heart function, blood flow, and morphogenesis of heart structure during the formation of a four-chambered heart. It is known that changes in vitelline and placental blood flow seemingly contribute substantially to early cardiac hemodynamics. This suggests that in order to understand mammalian cardiac structure-hemodynamic functional relationships, blood flow from the extra-embryonic circulation needs to be taken into account and its possible impact on cardiogenesis defined...
2014: Frontiers in Physiology
Kedryn K Baskin, Chad E Grueter, Christine M Kusminski, William L Holland, Angie L Bookout, Santosh Satapati, Y Megan Kong, Shawn C Burgess, Craig R Malloy, Philipp E Scherer, Christopher B Newgard, Rhonda Bassel-Duby, Eric N Olson
The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra-cardiac tissue(s) that respond to cardiac MED13 signaling. We show that cardiac overexpression of MED13 in transgenic (MED13cTg) mice confers a lean phenotype that is associated with increased lipid uptake, beta-oxidation and mitochondrial content in white adipose tissue (WAT) and liver...
December 2014: EMBO Molecular Medicine
Allan J Walkey, Serkalem Demissie, Dilip Shah, Freddy Romero, Leah Puklin, Ross S Summer
OBJECTIVE: Adiponectin (APN) is an anti-inflammatory hormone derived from adipose tissue that attenuates acute lung injury in rodents. In this study, we investigated the association between circulating APN and outcomes among patients with acute respiratory distress syndrome (ARDS). METHODS: We performed a retrospective cohort study using data and plasma samples from participants in the multicenter ARDS Network Fluid and Catheter Treatment Trial. RESULTS: Plasma APN concentrations were measured in 816 (81...
2014: PloS One
Jukka Vaahersalo, Markus B Skrifvars, Kari Pulkki, Mats Stridsberg, Helge Røsjø, Seppo Hovilehto, Marjaana Tiainen, Tero Varpula, Ville Pettilä, Esko Ruokonen
AIM OF THE STUDY: To study plasma concentrations of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and S-100B during intensive care after out-of-hospital cardiac arrest from ventricular fibrillation (OHCA-VF), and their associations with the duration of ischemia, organ dysfunction and long-term neurological outcome. MATERIALS AND METHODS: A 12-month prospective observational multicentre study was conducted in 21 Finnish intensive care units in 2011...
November 2014: Resuscitation
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