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Extra-cardiac circulation

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https://www.readbyqxmd.com/read/28262284/flow-mixing-during-peripheral-veno-arterial-extra-corporeal-membrane-oxygenation-a-simulation-study
#1
M C Stevens, F M Callaghan, P Forrest, P G Bannon, S M Grieve
Peripheral veno-arterial extra-corporeal membrane oxygenation (ECMO) is an artificial circulation that supports patients with severe cardiac and respiratory failure. Differential hypoxia during ECMO support has been reported, and it has been suggested that it is due to the mixing of well-perfused retrograde ECMO flow and poorly-perfused antegrade left ventricle (LV) flow in the aorta. This study aims to quantify the relationship between ECMO support level and location of the mixing zone (MZ) of the ECMO and LV flows...
April 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28186704/mesenchymal-stromal-cells-modulate-monocytes-trafficking-in-coxsackievirus-b3-induced-myocarditis
#2
Kapka Miteva, Kathleen Pappritz, Muhammad El-Shafeey, Fengquan Dong, Jochen Ringe, Carsten Tschöpe, Sophie Van Linthout
Mesenchymal stromal cell (MSC) application in Coxsackievirus B3 (CVB3)-induced myocarditis reduces myocardial inflammation and fibrosis, exerts prominent extra-cardiac immunomodulation, and improves heart function. Although the abovementioned findings demonstrate the benefit of MSC application, the mechanism of the MSC immunomodulatory effects leading to a final cardioprotective outcome in viral myocarditis remains poorly understood. Monocytes are known to be a trigger of myocardial tissue inflammation. The present study aims at investigating the direct effect of MSC on the mobilization and trafficking of monocytes to the heart in CVB3-induced myocarditis...
April 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28180202/applicability-and-technical-aspects-of-two-dimensional-ultrasonography-for-assessment-of-fetal-heart-function
#3
REVIEW
Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Luciano Marcondes Nardozza, Alex Sandro Souza, Edward Araujo Júnior
In recent years, fetal echocardiography has been used for the screening and diagnosis of anatomical heart defects and for the detailed study of fetal cardiac function. This method is characterized by its easy implementation and good reproducibility, allowing the diagnosis of myocardial dysfunction even in its subclinical phase. The functional assessment of the fetal heart should be routinely performed in fetuses with congenital heart disease and those without anatomical malformation. Several extra-cardiac conditions may alter fetal cardiac function, by increased placental resistance, volume overload or hyperdynamic circulation, compression, or maternal systemic disease with involvement of the fetal myocardium...
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28166944/recover-of-peripheral-nerve-function-after-prolong-hypothermic-cardiac-arrest-in-a-porcine-model-with-extra-corporeal-life-support
#4
Benedict Kjaergaard, Cristian Sevcencu, Sigridur Olga Magnusdottir, Henrik Bygum Krarup, Thomas Nørgaard Nielsen
OBJECTIVES: Surviving long lasting cardiac arrest following accidental hypothermia has been reported after treatment with extra corporeal life support (ECLS), but there is a risk of neurologic injury. Most surviving hypothermia patients have a prolonged stay in the intensive care unit, where most patients experience polyneuropathy. Theoretically, accidental hypothermic cardiac arrest may in itself contribute to polyneuropathy. This study was designed to examine the impact of three hours of cardiac arrest at a core temperature of 20°C followed by reanimation of peripheral nerve function...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28074802/goal-directed-therapy-improves-the-outcome-of-high-risk-cardiac-patients-undergoing-off-pump-coronary-artery-bypass
#5
RANDOMIZED CONTROLLED TRIAL
Poonam Malhotra Kapoor, Rohan Magoon, Rajinder Singh Rawat, Yatin Mehta, Sameer Taneja, R Ravi, Milind P Hote
BACKGROUND: There has been a constant emphasis on developing management strategies to improve the outcome of high-risk cardiac patients undergoing surgical revascularization. The performance of coronary artery bypass surgery on an off-pump coronary artery bypass (OPCAB) avoids the risks associated with extra-corporeal circulation. The preliminary results of goal-directed therapy (GDT) for hemodynamic management of high-risk cardiac surgical patients are encouraging. The present study was conducted to study the outcome benefits with the combined use of GDT with OPCAB as compared to the conventional hemodynamic management...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/27829827/the-prognostic-value-of-using-ultrasonography-in-cardiac-resuscitation-of-patients-with-cardiac-arrest
#6
Ehsan Bolvardi, Seyyed Mohsen Pouryaghobi, Roohye Farzane, Niaz Mohamad Jafari Chokan, Koorosh Ahmadi, Hamidreza Reihani
Cardiopulmonary arrest is the final result of many diseases and therefore, need for a careful implementation of cardiopulmonary resuscitation (CPR) protocols in these cases is undeniably important. The introduction of ultrasound into the emergency department has potentially allowed the addition of an extra data point in the decision about when to cease cardiopulmonary resuscitation (CPR). The aim of this study is to evaluate the ability of cardiac ultrasonography performed by emergency physicians to predict resuscitation outcome in adult cardiac arrest patients...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27806817/total-cavopulmonary-connection-for-functionally-single-ventricle-without-cardiopulmonary-bypass-support
#7
Sohail Khan Bangash, Iqbal Hussain Pathan, Saad Bader Zaki
A heart with two atriums but one ventricle, an anatomy with a unique physiology, is responsible for many creative surgical and interventional approaches in history. Different surgical techniques have been used to address this strange physiology of parallel circulation. All these attempts met with failure till the concept of Fontan circulation was described. Currently, controversy exists between multistage vs. single stage total cavopulmonary connections. Total cavopulmonary connection is the only definitive procedure performed to provide palliation for patients with complex congenital heart defects which cannot support a biventricular circulation...
October 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27661292/interrelationship-between-3-5-3%C3%A2-triiodothyronine-and-the-circadian-clock-in-the-rodent-heart
#8
Rodrigo Antonio Peliciari-Garcia, Rafael Maso Prévide, Maria Tereza Nunes, Martin Elliot Young
Triiodothyronine (T3) is an important modulator of cardiac metabolism and function, often through modulation of gene expression. The cardiomyocyte circadian clock is a transcriptionally based molecular mechanism capable of regulating cardiac processes, in part by modulating responsiveness of the heart to extra-cardiac stimuli/stresses in a time-of-day (TOD)-dependent manner. Although TOD-dependent oscillations in circulating levels of T3 (and its intermediates) have been established, oscillations in T3 sensitivity in the heart is unknown...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27614590/unilateral-absence-of-the-right-pulmonary-artery-with-associated-aortopulmonary-collaterals-and-bullous-lung-lesions-in-a-dog
#9
S Birch, D Casamian-Sorrosal, S Fonfara, G Chanoit, C Warren-Smith
This case report describes a combination of congenital cardiopulmonary abnormalities found in a 1-year-old Labrador Retriever. To the authors' knowledge this combination of cardiopulmonary abnormalities has not been previously reported in veterinary medicine. Unilateral absence of the right pulmonary artery associated with unilateral right-sided aortopulmonary collaterals was observed. These aortopulmonary collaterals preserved the blood supply to the right lung lobes but led to left ventricular volume overload...
December 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27607599/temporal-changes-in-clot-lysis-and-clot-stability-following-tranexamic-acid-in-cardiac-surgery
#10
Mariann Tang, Per Wierup, Catherine J Rea, Jrgen Ingerslev, Vibeke E Hjortdal, Benny Srensen
Cardiac surgery induces a multifactorial coagulopathy. Regular use of tranexamic acid (TXA) is becoming standard of care. Clinical challenges include selecting optimal dosing regimen and balancing the benefit versus risk of additional dosing with antifibrinolytics. The objective was to evaluate the effect of TXA by assessing kinetic properties of plasma clot formation, clot stability, and clot fibrinolysis. The study was a prospective case follow-up of 28 patients undergoing cardiac surgery (mean age 63.9 years, 29% women)...
September 2, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27537180/high-iron-consumption-impairs-growth-and-causes-copper-deficiency-anemia-in-weanling-sprague-dawley-rats
#11
Jung-Heun Ha, Caglar Doguer, Xiaoyu Wang, Shireen R Flores, James F Collins
Iron-copper interactions were described decades ago; however, molecular mechanisms linking the two essential minerals remain largely undefined. Investigations in humans and other mammals noted that copper levels increase in the intestinal mucosa, liver and blood during iron deficiency, tissues all important for iron homeostasis. The current study was undertaken to test the hypothesis that dietary copper influences iron homeostasis during iron deficiency and iron overload. We thus fed weanling, male Sprague-Dawley rats (n = 6-11/group) AIN-93G-based diets containing high (~8800 ppm), adequate (~80) or low (~11) iron in combination with high (~183), adequate (~8) or low (~0...
2016: PloS One
https://www.readbyqxmd.com/read/26947424/differential-visceral-blood-flow-in-the-hyperdynamic-circulation-of-patients-with-liver-cirrhosis
#12
N C McAvoy, S Semple, J M J Richards, A J Robson, D Patel, A G M Jardine, K Leyland, A S Cooper, D E Newby, P C Hayes
BACKGROUND: With advancing liver disease and the development of portal hypertension, there are major alterations in somatic and visceral blood flow. Using phase-contrast magnetic resonance angiography, we characterised alterations in blood flow within the hepatic, splanchnic and extra-splanchnic circulations of patients with established liver cirrhosis. AIM: To compare blood flow in splanchnic and extra-splanchnic circulations in patients with varying degrees of cirrhosis and healthy controls...
May 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26819269/use-of-minimal-invasive-extracorporeal-circulation-in-cardiac-surgery-principles-definitions-and-potential-benefits-a-position-paper-from-the-minimal-invasive-extra-corporeal-technologies-international-society-miectis
#13
Kyriakos Anastasiadis, John Murkin, Polychronis Antonitsis, Adrian Bauer, Marco Ranucci, Erich Gygax, Jan Schaarschmidt, Yves Fromes, Alois Philipp, Balthasar Eberle, Prakash Punjabi, Helena Argiriadou, Alexander Kadner, Hansjoerg Jenni, Guenter Albrecht, Wim van Boven, Andreas Liebold, Fillip de Somer, Harald Hausmann, Apostolos Deliopoulos, Aschraf El-Essawi, Valerio Mazzei, Fausto Biancari, Adam Fernandez, Patrick Weerwind, Thomas Puehler, Cyril Serrick, Frans Waanders, Serdar Gunaydin, Sunil Ohri, Jan Gummert, Gianni Angelini, Volkmar Falk, Thierry Carrel
Minimal invasive extracorporeal circulation (MiECC) systems have initiated important efforts within science and technology to further improve the biocompatibility of cardiopulmonary bypass components to minimize the adverse effects and improve end-organ protection. The Minimal invasive Extra-Corporeal Technologies international Society was founded to create an international forum for the exchange of ideas on clinical application and research of minimal invasive extracorporeal circulation technology. The present work is a consensus document developed to standardize the terminology and the definition of minimal invasive extracorporeal circulation technology as well as to provide recommendations for the clinical practice...
May 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26804603/exercise-before-and-after-scuba-diving-and-the-role-of-cellular-microparticles-in-decompression-stress
#14
Dennis Madden, Stephen R Thom, Zeljko Dujic
Risk in SCUBA diving is often associated with the presence of gas bubbles in the venous circulation formed during decompression. Although it has been demonstrated time-after-time that, while venous gas emboli (VGE) often accompany decompression sickness (DCS), they are also frequently observed in high quantities in asymptomatic divers following even mild recreational dive profiles. Despite this VGE are commonly utilized as a quantifiable marker of the potential for an individual to develop DCS. Certain interventions such as exercise, antioxidant supplements, vibration, and hydration appear to impact VGE production and the decompression process...
January 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/26514357/the-clinical-and-histological-spectrum-of-idiopathic-inflammatory-myopathies
#15
REVIEW
Ilaria Cavazzana, Micaela Fredi, Carlo Selmi, Angela Tincani, Franco Franceschini
Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of myositis, characterised by chronic muscle weakness, cutaneous features, different extra-muscular manifestations and circulating autoantibodies. IIMs included classical polymyositis (PM), dermatomyositis (DM) and other different types of myositis with a wide range of muscle involvement. A complete autoantibody profile and a muscle biopsy are mandatory to correctly diagnose different clinical entities and to define their different prognosis...
February 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/26497659/a-novel-intra-operative-high-resolution-atrial-mapping-approach
#16
Ameeta Yaksh, Lisette J M E van der Does, Charles Kik, Paul Knops, Frans B S Oei, Pieter C van de Woestijne, Jos A Bekkers, Ad J J C Bogers, Maurits A Allessie, Natasja M S de Groot
PURPOSE: A new technique is demonstrated for extensive high-resolution intra-operative atrial mapping that will facilitate the localization of atrial fibrillation (AF) sources and identification of the substrate perpetuating AF. METHODS: Prior to the start of extra-corporal circulation, a 8 × 24-electrode array (2-mm inter-electrode distance) is placed subsequently on all the right and left epicardial atrial sites, including Bachmann's bundle, for recording of unipolar electrograms during sinus rhythm and (induced) AF...
December 2015: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/26466501/-a-case-of-undiagnosed-extra-adrenal-pheochromocytoma-in-an-adult-patient-with-single-ventricle-circulation-after-the-bidirectional-glenn-operation
#17
Masaki Kohno, Yusuke Nagamine, Takahisa Goto
We experienced a case of undiagnosed extra-adrenal pheochromocytoma in an adult patient with single ventricle circulation after the bidirectional Glenn operation. A 32-year-old woman was scheduled for open abdominal surgery for incidental retroperitoneal tumor. She had undergone the bidirectional Glenn operation for complex congenital heart disease consisting of double outlet right ventricle, ventricular septal defect, and pulmonary artery stenosis. She had not undergone the Fontan operation because of insufficient development of pulmonary circulation...
September 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26422953/-validity-of-near-infrared-spectroscopy
#18
REVIEW
Kenji Yoshitani, Yoshihiko Ohnishi
Regional cerebral oxygen saturation measured by near-infrared spectroscopy has been used clinically. Its usefulness in cardiac surgery and neurosurgery was also reported. On the other hand, accuracy of rSO2 values has been supposed to be doubtful due to extra-cerebral contamination and unstable mean optical path-length. Therefore, we tried to review issues for accuracy of rSO2 values and clinical usefulness. Our aim is to clarify the issue and clinical usefulness of measuring regional cerebral oxygen saturation...
May 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26417594/circulating-s100b-and-adiponectin-in-children-who-underwent-open-heart-surgery-and-cardiopulmonary-bypass
#19
Alessandro Varrica, Angela Satriano, Alessandro Frigiola, Alessandro Giamberti, Guido Tettamanti, Luigi Anastasia, Erika Conforti, Antonio D W Gavilanes, Luc J Zimmermann, Hans J S Vles, Giovanni Li Volti, Diego Gazzolo
BACKGROUND: S100B protein, previously proposed as a consolidated marker of brain damage in congenital heart disease (CHD) newborns who underwent cardiac surgery and cardiopulmonary bypass (CPB), has been progressively abandoned due to S100B CNS extra-source such as adipose tissue. The present study investigated CHD newborns, if adipose tissue contributes significantly to S100B serum levels. METHODS: We conducted a prospective study in 26 CHD infants, without preexisting neurological disorders, who underwent cardiac surgery and CPB in whom blood samples for S100B and adiponectin (ADN) measurement were drawn at five perioperative time-points...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26357793/an-evaluation-trial-of-the-national-perfusion-registry
#20
Makoto Hibiya, Tetsuya Kamei, Kiyoshi Yoshida, Shoji Kubota, Hiroya Kano, Tomohiro Nakamura, Saori Ishida, Chihiro Saito, Kyoichi Kemmoku
The International Consortium for Evidence-Based Perfusion (ICEBP) is a collaborative group whose mission is to improve, continuously, the delivery of care and outcomes for patients undergoing cardiac surgery. To achieve this end, the ICEBP supports the development of perfusion registries to evaluate clinical practices and has established evidence-based guidelines for perfusion. The Japanese Society of Extra-Corporeal Technology in Medicine (JaSECT) developed a perfusion registry to examine variation in perfusion practice in Japan...
September 2014: Journal of Extra-corporeal Technology
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