keyword
MENU ▼
Read by QxMD icon Read
search

stress response envelope

keyword
https://www.readbyqxmd.com/read/28922502/the-three-component-system-esrisr-regulates-a-cell-envelope-stress-response-in-corynebacterium-glutamicum
#1
Britta Kleine, Ava Chattopadhyay, Tino Polen, Daniela Pinto, Thorsten Mascher, Michael Bott, Melanie Brocker, Roland Freudl
When the cell envelope integrity is compromised, bacteria trigger signaling cascades resulting in the production of proteins that counteract these extracytoplasmic stresses. Here, we show that the two-component system EsrSR regulates a cell envelope stress response in the Actinobacterium Corynebacterium glutamicum. The sensor kinase EsrS possesses an amino-terminal phage shock protein C (PspC) domain, a property that sets EsrSR apart from all other two-component systems characterized so far. An integral membrane protein, EsrI, whose gene is divergently transcribed to the esrSR gene locus and which interestingly also possesses a PspC domain, acts as an inhibitor of EsrSR under non-stress conditions...
September 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28910825/comparison-of-continuous-wave-and-micropulse-modulation-in-retinal-laser-therapy
#2
Jenny Wang, Yi Quan, Roopa Dalal, Daniel Palanker
Purpose: Recent progress in retinal laser therapy has centered upon using thermal stress below damage threshold or selective destruction of targeted tissue layers as a stimulus for retinal repair. Temporal modulation, including micropulse, is thought to increase the selectivity of laser treatment, but has not been carefully analyzed. We measure and model the tissue response to continuous-wave (CW) and micropulse laser to evaluate the advantages and drawbacks of temporal modulation. Methods: Thresholds of ophthalmoscopic visibility, which indicates damage to photoreceptors, and fluorescein angiography (FA), indicating damage to retinal pigment epithelium (RPE), were measured with 577-nm laser in rabbits for duty cycles ranging from 3% to 100% (CW) and pulse envelopes of 20 and 200 ms...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28906045/actinorhodin-is-a-redox-active-antibiotic-with-a-complex-mode-of-action-against-gram-positive-cells
#3
Stefanie Mak, Justin R Nodwell
Actinorhodin is a blue-pigmented, redox-active secondary metabolite that is produced by the bacterium Streptomyces coelicolor. Although actinorhodin has been used as a model compound for studying secondary metabolism, its biological activity is not well understood. Indeed, redox-active antibiotics in general have not been widely investigated at the mechanistic level. In this work, we have conducted a comprehensive chemical genetic investigation of actinorhodin's antibacterial effect on target organisms. We find that actinorhodin is a potent, bacteriostatic, pH-responsive antibiotic...
September 14, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28883824/natural-killer-nk-cell-education-differentially-influences-hiv-antibody-dependent-nk-cell-activation-and-antibody-dependent-cellular-cytotoxicity
#4
REVIEW
Nicole F Bernard, Zahra Kiani, Alexandra Tremblay-McLean, Sanket A Kant, Christopher E Leeks, Franck P Dupuy
Immunotherapy using broadly neutralizing antibodies (bNAbs) endowed with Fc-mediated effector functions has been shown to be critical for protecting or controlling viral replication in animal models. In human, the RV144 Thai trial was the first trial to demonstrate a significant protection against HIV infection following vaccination. Analysis of the correlates of immune protection in this trial identified an association between the presence of antibody-dependent cellular cytotoxicity (ADCC) mediated by immunoglobulin G (IgG) antibodies (Abs) to HIV envelope (Env) V1/V2 loop structures and protection from infection, provided IgA Abs with competing specificity were not present...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28875939/within-host-envelope-remodelling-and-its-impact-in-bacterial-pathogen-recognition
#5
M Graciela Pucciarelli, Francisco García-Del Portillo
Following colonization of host tissues, bacterial pathogens encounter new niches in which they must gain access to nutrients and cope with stresses and defence signals generated by the host. For some pathogens, the adaptation to a new 'within-host' lifestyle involves modifications of envelope components that bear molecular patterns normally recognized by the host innate immune system. These new modified patterns limit host recognition, therefore promoting immune evasion and pathogenicity. In this review, we describe how envelope components like the peptidoglycan or lipopolysaccharide can be altered within the host to impair responses triggered by pattern recognition receptors (PRR)...
September 6, 2017: Current Issues in Molecular Biology
https://www.readbyqxmd.com/read/28874409/extracellular-salb-contributes-to-intrinsic-cephalosporin-resistance-and-cell-envelope-integrity-in-enterococcus-faecalis
#6
Dušanka Djorić, Christopher J Kristich
Enterococci are major causes of hospital-acquired infections. Intrinsic resistance to cephalosporins is a universal trait among clinically relevant enterococci. Cephalosporin resistance enables enterococci to proliferate to high densities in the intestines of patients undergoing cephalosporin treatment, a precursor to the emergence of infection. However, the genetic and biochemical mechanisms of intrinsic cephalosporin resistance in enterococci are not well understood. A two-component signal transduction system, CroR/S, is required for cephalosporin resistance in enterococci...
September 5, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28854955/identification-of-two-mutation-sites-in-spike-and-envelope-proteins-mediating-optimal-cellular-infection-of-porcine-epidemic-diarrhea-virus-from-different-pathways
#7
Min Sun, Jiale Ma, Zeyanqiu Yu, Zihao Pan, Chengping Lu, Huochun Yao
Entry of the α-coronavirus porcine epidemic diarrhea virus (PEDV) requires specific proteases to activate spike (S) protein for the membrane fusion of the virion to the host cell following receptor binding. Herein, PEDV isolate 85-7 could proliferate and induce cell-cell fusion in a trypsin independent manner on Vero cells, and eight homologous mutation strains were screened by continuous proliferation in the absence of trypsin on Vero cells. According to the whole genome sequence comparative analysis, we identified four major variations located in nonstructural protein 2, S, open reading frame 3, and envelope (E) genes, respectively...
August 30, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28840318/how-innate-immunity-proteins-kill-bacteria-and-why-they-are-not-prone-to-resistance
#8
REVIEW
Roman Dziarski, Dipika Gupta
Recent advances on antibacterial activity of peptidoglycan recognition proteins (PGRPs) offer some insight into how innate immunity has retained its antimicrobial effectiveness for millions of years with no frequent emergence of resistant strains. First, PGRP can bind to multiple components of bacterial envelope (peptidoglycan, lipoteichoic acid, and lipopolysaccharide). Second, PGRP simultaneously induces oxidative, thiol, and metal stress responses in bacteria, which individually are bacteriostatic, but in combination are bactericidal...
August 24, 2017: Current Genetics
https://www.readbyqxmd.com/read/28829780/proteomic-analysis-of-potentilla-fruticosa-l-leaves-by-itraq-reveals-responses-to-heat-stress
#9
Yingtian Guo, Zhi Wang, Xuelian Guan, Zenghui Hu, Ze Zhang, Jian Zheng, Yizeng Lu
High temperature is an important environmental factor that affects plant growth and crop yield. Potentilla fruticosa L. has a developed root system and characteristics of resistance to several stresses (e.g., high temperature, cold, drought) that are shared by native shrubs in the north and west of China. To investigate thermotolerance mechanisms in P. fruticosa, 3-year-old plants were subjected to a high temperature of 42°C for 1, 2, and 3 days respectively before analysis. Then, we studied changes in cell ultrastructure using electron microscopy and investigated physiological changes in the leaves of P...
2017: PloS One
https://www.readbyqxmd.com/read/28821232/genomic-transcriptomic-and-proteomic-approaches-towards-understanding-the-molecular-mechanisms-of-salt-tolerance-in-frankia-strains-isolated-from-casuarina-trees
#10
Rediet Oshone, Mariama Ngom, Feixia Chu, Samira Mansour, Mame Ourèye Sy, Antony Champion, Louis S Tisa
BACKGROUND: Soil salinization is a worldwide problem that is intensifying because of the effects of climate change. An effective method for the reclamation of salt-affected soils involves initiating plant succession using fast growing, nitrogen fixing actinorhizal trees such as the Casuarina. The salt tolerance of Casuarina is enhanced by the nitrogen-fixing symbiosis that they form with the actinobacterium Frankia. Identification and molecular characterization of salt-tolerant Casuarina species and associated Frankia is imperative for the successful utilization of Casuarina trees in saline soil reclamation efforts...
August 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28816060/the-broad-spectrum-antimicrobial-potential-of-mn-co-4-s2cnme-ch2co2h-a-water-soluble-co-releasing-molecule-corm-401-intracellular-accumulation-transcriptomic-and-statistical-analyses-and-membrane-polarization
#11
Lauren Katie Wareham, Samantha McLean, Ronald Begg, Namrata Rana, Salar Ali, John J Kendall, Guido Sanguinetti, Brian E Mann, Robert K Poole
AIMS: Carbon monoxide (CO)-releasing molecules (CORMs) are candidates for animal and antimicrobial therapeutics. We aimed to probe the antimicrobial potential of a novel manganese CORM. RESULTS: [Mn(CO)4S2CNMe(CH2CO2H)], CORM-401, inhibits growth of Escherichia coli and several antibiotic-resistant clinical pathogens. CORM-401 releases CO that binds oxidases in vivo but is an ineffective respiratory inhibitor. Extensive CORM accumulation (assayed as intracellular manganese) accompanies antimicrobial activity...
August 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28807687/influence-of-tween-80-on-the-production-and-structure-of-water-insoluble-curdlan-from-agrobacterium-sp
#12
Ying Liang, Li Zhu, Minjie Gao, Zhiyong Zheng, Jianrong Wu, Xiaobei Zhan
In order to explore the mechanism by which Tween-80 enhances the production of curdlan produced by Agrobacterium sp., the effects of Tween-80 on the production and structure of curdlan and Agrobacterium sp. were evaluated. Maximum curdlan production (51.94g/L) was achieved when 16g/L Tween-80 was added at the beginning of the cell growth stage. The addition of Tween-80 at higher concentration inhibited cell growth. However, the addition of 16g/L Tween-80 enhanced the production of curdlan with a looser ultrastructure, significantly weakened the envelopment of curdlan on Agrobacterium sp...
August 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28760852/stress-reduction-bacterial-style
#13
Susan Gottesman
Bacteria have robust responses to a variety of stresses. In particular, bacteria like Escherichia coli have multiple cell envelope stress responses, and generally we evaluate what these responses are doing by the repair systems they induce. However, probably at least as important in interpreting what is being sensed as stress are the genes that these stress systems down-regulate, directly or indirectly. This is discussed here for the Cpx and Sigma E systems of E. coli.
July 31, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28760851/a-bacterial-stress-response-regulates-expression-of-respiratory-protein-complexes-to-control-envelope-stress-adaptation
#14
Randi L Guest, Junshu Wang, Julia L Wong, Tracy L Raivio
The Cpx envelope stress response mediates adaptation to stresses that affect protein folding within the envelope of gram-negative bacteria. Recent transcriptome analyses revealed that the Cpx response impacts genes that affect multiple cellular functions predominantly associated with the cytoplasmic membrane. In this study, we examined the connection between the Cpx response and the respiratory complexes NADH dehydrogenase I and cytochrome bo3 in enteropathogenic Escherichia coli We found that the Cpx response directly represses transcription of the nuo and cyo operons and that Cpx-mediated repression of these complexes confers adaptation to stresses that compromise envelope integrity...
July 31, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28753640/mycobacterium-tuberculosis-universal-stress-protein-rv2623-interacts-with-the-putative-atp-binding-cassette-abc-transporter-rv1747-to-regulate-mycobacterial-growth
#15
Lisa N Glass, Ganduri Swapna, Sivagami Sundaram Chavadi, JoAnn M Tufariello, Kaixia Mi, Joshua E Drumm, TuKiet T Lam, Guofeng Zhu, Chenyang Zhan, Catherine Vilchéze, Jesus Arcos, Yong Chen, Lijun Bi, Simren Mehta, Steven A Porcelli, Steve C Almo, Syun-Ru Yeh, William R Jacobs, Jordi B Torrelles, John Chan
We have previously shown that the Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth and may be required for the establishment of tuberculous persistence. Here, yeast two-hybrid and affinity chromatography experiments have demonstrated that Rv2623 interacts with one of the two forkhead-associated domains (FHA I) of Rv1747, a putative ATP-binding cassette transporter annotated to export lipooligosaccharides. FHA domains are signaling protein modules that mediate protein-protein interactions to modulate a wide variety of biological processes via binding to conserved phosphorylated threonine (pT)-containing oligopeptides of the interactors...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28749938/the-mecillinam-resistome-reveals-a-role-for-peptidoglycan-endopeptidases-in-stimulating-cell-wall-synthesis-in-escherichia-coli
#16
Ghee Chuan Lai, Hongbaek Cho, Thomas G Bernhardt
Bacterial cells are typically surrounded by an net-like macromolecule called the cell wall constructed from the heteropolymer peptidoglycan (PG). Biogenesis of this matrix is the target of penicillin and related beta-lactams. These drugs inhibit the transpeptidase activity of PG synthases called penicillin-binding proteins (PBPs), preventing the crosslinking of nascent wall material into the existing network. The beta-lactam mecillinam specifically targets the PBP2 enzyme in the cell elongation machinery of Escherichia coli...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28741415/gram-negative-bacterial-membrane-vesicle-release-in-response-to-the-host-environment-different-threats-same-trick
#17
Charlotte Volgers, Paul H M Savelkoul, Frank R M Stassen
Bacteria are confronted with a multitude of stressors when occupying niches within the host. These stressors originate from host defense mechanisms, other bacteria during niche competition or result from physiological challenges such as nutrient limitation. To counteract these stressors, bacteria have developed a stress-induced network to mount the adaptations required for survival. These stress-induced adaptations include the release of membrane vesicles from the bacterial envelope. Membrane vesicles can provide bacteria with a plethora of immediate and ultimate benefits for coping with environmental stressors...
July 25, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28738195/proteomic-and-genetics-insights-on-the-response-of-the-bacteriocinogenic-lactobacillus-sakei-crl1862-during-biofilm-formation-on-stainless-steel-surface-at-10%C3%A2-c
#18
Mariana Pérez-Ibarreche, Lucía M Mendoza, Graciela Vignolo, Silvina Fadda
Some lactic acid bacteria have the ability to form biofilms on food-industry surfaces and this property could be used to control food pathogens colonization. Lactobacillus sakei CR1862 was selected considering its bacteriocinogenic nature and ability to adhere to abiotic surfaces at low temperatures. In this study, the proteome of L. sakei CRL1862 grown either under biofilm on stainless steel surface and planktonic modes of growth at 10°C, was investigated. Using two-dimensional gel electrophoresis, 29 out of 43 statistically significant spots were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
July 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28713776/modulation-of-trehalose-dimycolate-and-immune-system-by-rv0774c-protein-enhanced-the-intracellular-survival-of-mycobacterium-smegmatis-in-human-macrophages-cell-line
#19
Arbind Kumar, Varinder Saini, Anjani Kumar, Jasbinder Kaur, Jagdeep Kaur
Mycobacterium tuberculosis Rv0774c protein was reported previously to express under stress conditions. Therefore, Rv0774c gene was cloned and expressed in Mycobacterium smegmatis, a surrogate host, to determine its role in bacterial persistence and immune modulation in natural environment. The bacterial colonies expressing Rv0774c (Ms_rv0774c) were larger, smoother, more moist, and flatter than the control ones (Ms_ve). Enhanced survival of Ms_rv0774c after treatment with streptomycin was observed when compared with control...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28674071/-major-tom-to-ground-control-how-lipoproteins-communicate-extra-cytoplasmic-stress-to-the-decision-center-of-the-cell
#20
Géraldine Laloux, Jean-François Collet
The envelope of bacteria is a complex multi-layered shield that ensures multiple essential functions, including protecting the cell from external assaults. Hence, bacterial cells have evolved intricate mechanisms, called envelope stress response systems (ESRS), to monitor all kinds of perturbations affecting the integrity of their envelope and mount an appropriate response to contain or repair the damage. In the model bacterium Escherichia coli, several ESRS are built around a two-component system, in which envelope stress triggers a phosphotransfer between a sensor protein in the inner membrane of the envelope and a response regulator in the cytoplasm...
July 3, 2017: Journal of Bacteriology
keyword
keyword
109916
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"