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Lactate AND ERR alpha

Shabnam Pooya, Sébastien Blaise, Maira Moreno Garcia, Jean Giudicelli, Jean-Marc Alberto, Rosa-Maria Guéant-Rodriguez, Elise Jeannesson, Naig Gueguen, Aude Bressenot, Bénédicte Nicolas, Yves Malthiery, Jean-Luc Daval, Laurent Peyrin-Biroulet, Jean-Pierre Bronowicki, Jean-Louis Guéant
BACKGROUND & AIMS: Folate and cobalamin are methyl donors needed for the synthesis of methionine, which is the precursor of S-adenosylmethionine, the substrate of methylation in epigenetic, and epigenomic pathways. Methyl donor deficiency produces liver steatosis and predisposes to metabolic syndrome. Whether impaired fatty acid oxidation contributes to this steatosis remains unknown. METHODS: We evaluated the consequences of methyl donor deficient diet in liver of pups from dams subjected to deficiency during gestation and lactation...
August 2012: Journal of Hepatology
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