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https://www.readbyqxmd.com/read/28525681/unveiling-idiopathic-macular-telangiectasia-clinical-applications-of-optical-coherence-tomography-angiography
#1
Marco A Gonzalez, Diana Shechtman, Jay M Haynie, Leo Semes
PURPOSE: Idiopathic macular telangiectasia type 2 (IMT2) is a bilateral acquired maculopathy, with a spectrum of clinical presentations associated with inner retinal telangiectatic vascular anomalies. Cases often are underdiagnosed or misdiagnosed. Current diagnostic modalities such as spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) are valuable to the understanding of the clinicopathology. More recently, optical coherence tomography angiography (OCTA), as an emerging noninvasive technology, has been shown to be particularly useful in the assessment and management of IMT2...
May 19, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28524912/gold-nanocages-with-dual-modality-for-image-guided-therapeutics
#2
Shijin Bao, Shengnan Huang, Ying Liu, Yurong Hu, Weiping Wang, Mengfei Ji, Huili Li, Ning Xia Zhang, Chengzhi Song, Shaofeng Duan
Numerous studies have demonstrated that microRNAs are very important in cancer development and progression. However, the complex relationship between the size of microRNA delivery systems, cellular uptake, biodistribution and therapeutic efficiency remains unclear. Herein, we have successfully constructed a series of differently-sized microRNA delivery systems, miR-26a-loaded, hyaluronic acid-modified, polyetherimide-conjugated PEGylated gold nanocage ternary nanocomplexes (PPHAuNCs-TNCs), which can be monitored optically by fluorescence and photoacoustic tomography imaging...
May 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28524715/prevalence-of-age-related-macular-degeneration-in-slovakia-and-associated-risk-factors-a-mobile-clinic-based-cross-sectional-epidemiological-survey
#3
Vladimir Krasnik, Jana Stefanickova, Ivajlo Popov, Jela Valaskova, Sandeep Saxena, Peter Kruzliak
PURPOSE: Age-related macular degeneration (AMD) is one of the leading causes of blindness in the elderly population. Although there are prevalence studies for AMD in Europe, data are scarce for the Slovakian population. METHODS: This was a prospective, multicenter, non-interventional, mobile clinic-based cross-sectional study that assessed age-specific prevalence of AMD in the Slovakian population and risk factors associated with AMD. The type of AMD was graded based on the international age-related maculopathy grading system; optical coherence tomography (OCT) was used for the differential diagnosis...
May 19, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28524151/-etiopathogenesis-of-ocular-ischemic-syndrome
#4
D К Makhkamova
Ocular ischemic syndrome (OIS) is a collection of symptoms of carotid and ophthalmic artery disease of common genesis accompanied by ischemia of eyeball membranes. Specifically, the intraocular blood flow becomes impaired due to inflow reduction or arrest, while the venous outflow remains patent. Causes of OIS include arterial hypertension, atherosclerosis, diabetes, aortoarteritis and other vascular diseases. Clinical features depend on the extent, nature, and site of vascular involvement as well as the concurrent pathology...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524150/-functional-examinations-of-visual-channels-clinical-aspects
#5
M V Zueva, I V Tsapenko, E P Lantukh, N M Maglakelidze
The review discusses literature data on the clinical relevance of functional assessment of magno- (M), parvo- (P), and koniocellular (K) pathways. It also covers the differential contribution of the M, P, and K channels to visual impairments and how it determines the prognosis, early diagnosis, and treatment choice in patients with neurodegenerative diseases of the retina and brain. Selective changes in the performance of the visual channels are investigated by the example of glaucoma and optic neuritis in multiple sclerosis (MS) patients...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524148/-atypical-clinical-case-of-solar-retinopathy
#6
N V Pomytkina, A L Zhirov, T L Sorokin
The paper presents an atypical case of solar retinopathy after short-term exposure to reflected focused sunbeams. An ophthalmoscopic peculiarity was the presence of intraretinal hemorrhage. The basis for establishing the diagnosis were spectral optical coherence tomography and fluorescein angiography findings.
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524147/-complex-treatment-results-in-a-congenital-glaucoma-patient-case-report
#7
O L Fabrikantov, S I Nikolashin, Yu V Matrosova, V A Kozlov, A E Kopylov, E S Pirogova
Early diagnosis of congenital glaucoma allows surgery to be performed at the stage of reversible glaucomatous alterations of the optic disc and retina. In primary congenital glaucoma, the main reason for visual acuity reduction following surgical stabilization of the intraocular pressure are corneal changes. These include an increased corneal diameter, Haab's striae, areas of thickening and a greater posterior elevation. The resultant irregular astigmatism leads to amblyopia and a marked decrease in visual acuity...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28523457/retinal-pigmentary-changes-in-chronic-uveitis-mimicking-retinitis-pigmentosa
#8
D Damla Sevgi, Samaneh Davoudi, Jason Comander, Lucia Sobrin
PURPOSE: To present retinal pigmentary changes mimicking retinitis pigmentosa (RP) as a finding of advanced uveitis. METHODS: We retrospectively reviewed charts of patients without a family history of inherited retinal degenerations who presented with retinal pigment changes and signs of past or present intraocular inflammation. Comprehensive eye examination including best-corrected visual acuity, slit-lamp examination and dilated fundus examination was performed on all patients in addition to color fundus photography, optical coherence tomography, fluorescein angiography (FA), and full-field electroretinogram testing...
May 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28523304/optical-coherence-tomography-applications-in-tooth-wear-diagnosis
#9
Veronica MercuŢ, Sanda Mihaela Popescu, Monica Scrieciu, Marina Olimpia Amărăscu, Mihaela Vătu, Oana Andreea Diaconu, Eugen Osiac, Ştefan Mugurel Ghelase
Dental wear represents an irreversible loss of dental hard tissue under the action of physical, chemical and mechanical factors, excluding dental caries and acute trauma. Four clinical forms of dental wear are described: erosion, attrition, abfraction, and abrasion. Most experts agree that in each clinical form multiple etiological factors are involved, one being predominant. Optical coherence tomography (OCT) is a non-invasive optical method characterized by a micronic resolution. The applications of this type of investigation are multiple in the medical field in recent years, and OCT is gaining a growing importance in dentistry...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28521900/diagnosis-of-malarial-infection-using-change-in-properties-of-optically-trapped-red-blood-cells
#10
Apurba Paul, Ponnan Padmapriya, Vasant Natarajan
BACKGROUND: In previous work studying the properties of red blood cells (RBCs) held in an optical tweezers trap, we observed an increase in the spectrum of Brownian fluctuations for RBCs from a Plasmodium falciparum culture-due to increased rigidity of the cells-compared to normal RBCs. We wanted to extend the study to patient samples, since the earlier work was done with cultures grown in the lab. METHODS: Individual RBCs were held in an optical-tweezers trap. Its position fluctuations were measured and the power spectrum determined...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28515908/renal-manifestations-of-primary-mitochondrial-disorders
#11
Josef Finsterer, Fulvio Scorza
The aim of the present review was to summarize and discuss previous findings concerning renal manifestations of primary mitochondrial disorders (MIDs). A literature review was performed using frequently used databases. The study identified that primary MIDs frequently present as mitochondrial multiorgan disorder syndrome (MIMODS) at onset or in the later course of the MID. Occasionally, the kidneys are affected in MIDs. Renal manifestations of MIDs include renal insufficiency, nephrolithiasis, nephrotic syndrome, renal cysts, renal tubular acidosis, Bartter-like syndrome, Fanconi syndrome, focal segmental glomerulosclerosis, tubulointerstitial nephritis, nephrocalcinosis, and benign or malign neoplasms...
May 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28514814/-possibilities-and-limitations-of-oct-angiography-in-patients-with-central-serous-chorioretinopathy
#12
B Cakir, M Reich, S J Lang, A Bühler, A Stahl, D Böhringer, H Agostini, C Lange
Purpose Central serous chorioretinopathy (CSC) is a commonly acquired maculopathy characterized by the accumulation of subretinal fluid at the posterior pole. This study aims to analyze optical coherence tomography angiography (OCTA) findings in patients with acute and chronic CSC and to compare them to conventional imaging methods. Methods A series of 43 consecutive eyes of 29 patients diagnosed with CSC and 18 eyes of 9 healthy control subjects were included in this retrospective study. The OCTA images were assessed and compared to conventional fluorescence (FAG) and indocyanine green angiography (ICG)...
May 17, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28513892/assessment-of-nonarteritic-anterior-ischemic-optic-neuropathy-with-intravoxel-incoherent-motion-diffusion-weighted-imaging-using-readout-segmented-echo-planar-imaging-parallel-imaging-and-2d-navigator-based-reacquisition
#13
Ping Lu, Yan Sha, Hailin Wan, Feng Wang, Guohong Tan, Wenlin Tang
PURPOSE: To determine the feasibility of intravoxel incoherent motion (IVIM) for characterizing perfusion properties and its potential diagnostic utility for nonarteritic anterior ischemic optic neuropathy (NAION). IVIM diffusion-weighted imaging is a promising technique that can measure perfusion and diffusion characteristics simultaneously in a noninvasive manner. MATERIALS AND METHODS: Orbital IVIM in a 3.0T scanner was performed on 33 patients with NAION and 15 controls using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition (RESOLVE-IVIM)...
May 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28513699/multifunctional-nanoprobes-for-both-fluorescence-and-19-f-magnetic-resonance-imaging
#14
Chang Guo, Minmin Xu, Suying Xu, Leyu Wang
Fluorescence is widely used for cell imaging due to its high sensitivity and rich color choice but limited for in vivo imaging because of its low light penetration. Meanwhile, magnetic resonance imaging (MRI) is widely applied for in vivo diagnosis but not suitable for cell imaging because of its low resolution. Compared to (1)H-MRI, (19)F-MRI is more suitable for clinical application due to its high sensitivity but fabricating (19)F-MRI probes is a great challenge. Therefore, it is highly desirable to develop a dual-modal imaging probe for both cell fluorescence imaging and in vivo(19)F-MRI with high sensitivity and deep penetration...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28513113/retina-and-nerve-fiber-layer-thickness-in-eyes-with-thyroid-associated-ophthalmopathy
#15
Sharon Blum Meirovitch, Igal Leibovitch, Anat Kesler, David Varssano, Amir Rosenblatt, Meira Neuderfer
BACKGROUND: Thyroid-associated ophthalmopathy (TAO) is an inflammatory disease that affects the thyroid gland and the eye orbit. Of patients with TAO, 3%-5% have severe sight-threatening disease due to optic neuropathy Optical coherence tomography (OCT), the non-invasive imaging technology that yields high-resolution cross-sectional images of the retina, provides qualitative and quantitative data on the retina. OBJECTIVES: To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28512208/chorioretinitis-a-potential-clue-to-the-early-diagnosis-of-subacute-sclerosing-panencephalitis
#16
Vijayabala Jeevagan, Athula Dissanayake
We describe a 36-year-old man with subacute sclerosing panencephalitis (SSPE) presenting with chorioretinitis two years before onset of other neurological features. He had neither myoclonus nor the typical EEG features of SSPE. The diagnosis was confirmed in the appropriate clinical setting by detecting elevated measles antibody titres in cerebrospinal fluid and serum. Clinicians should consider SSPE among the differential diagnoses in chorioretinitis. This is particularly so if there is macular or perimacular involvement with concurrent involvement of the optic nerve in young patients, even without other characteristic neurological symptoms...
May 16, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28512100/anaemia-and-respiratory-failure-in-a-child-can-it-be-idiopathic-pulmonary-haemosiderosis
#17
Minhajuddin Ahmed, Dinesh Raj, Ashwini Kumar, Abhay Kumar
We present an 8-year-old male child admitted with cough and high-grade fever for 7 days and respiratory difficulty for 2 days. There was a history of blood transfusion at 2 years of age during a respiratory illness. The child was anaemic, tachycardic, tachypnoeic and hypoxic at presentation. Chest examination revealed equal air entry with fine crackles bilaterally. Blood reports were suggestive of anaemia (haemoglobin 6.5 g/dL), leucocytosis and high C reactive protein levels. Chest radiograph revealed bilateral air space opacities involving diffuse lung fields, right more than left...
May 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28510769/comparison-of-objective-and-subjective-techniques-of-strabismus-measurement-in-adults-with-normal-retinal-correspondence
#18
Derek P Bitner, Ore-Ofe O Adesina, Kai Ding, Bradley K Farris, R Michael Siatkowski
PURPOSE: Accurate measurement of strabismus is vital to proper diagnosis and treatment. Objective and subjective measurement techniques can be used. The authors hypothesized that subjective measurement techniques would measure larger deviations than objective ones. METHODS: Adults with strabismus, visual acuity greater than 20/50 in each eye, and normal retinal correspondence were measured in primary gaze at distance and near using the alternate prism and cover test and the red glass test...
May 15, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28509893/spontaneous-coronary-artery-dissection-insights-from-histology-and-optical-coherence-tomography
#19
Sandeep K Krishnan, Alex Zhu, Brent Larson, Timothy D Henry, Suhail Dohad
Spontaneous coronary artery dissection (SCAD) is a well-known but infrequent cause of acute coronary syndrome (ACS), and often goes unrecognized. Although management of SCAD is, at times, controversial, when a patient presents with ACS, percutaneous coronary intervention (PCI) is frequently necessary. We present a patient with ST-segment elevation myocardial infarction (STEMI) with SCAD that illustrates two important points: use of intracoronary optical coherence tomography to guide PCI, and histologic assessment to provide a unique insight into the etiology of SCAD...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28508380/-optical-coherence-tomography-in-eyes-with-senile-retinoschisis-sd-oct-versus-ultrasound-examinations-and-assessment-of-the-vitreoretinal-interface
#20
A Bringewatt, S Burzer, N Feucht, M Maier
BACKGROUND: In addition to ocular ultrasonography (US), spectral domain optical coherence tomography (SD-OCT) is available in order to diagnose senile retinoschisis (sRS). SD-OCT also allows for classification of posterior vitreous detachment (PVD) in healthy eyes. OBJECTIVES: Reevaluation of the value and additional benefit of both imaging procedures. SD-OCT-based evaluation of PVD stages in sRS patients. MATERIALS AND METHODS: Diagnostic results of 33 eyes in 26 patients with clinical suspicion of sRS were retrospectively analysed...
May 15, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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