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https://www.readbyqxmd.com/read/28917347/optical-diagnosis-of-early-colorectal-cancer-riding-the-highs%C3%A2-and-lows-of-the-japanese-narrow-band-imaging-expert%C3%A2-team-classification
#1
EDITORIAL
Sarah K McGill, Roy Soetikno, Tonya Kaltenbach
No abstract text is available yet for this article.
October 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28916508/development-of-a-whole-slide-imaging-system-on-smartphones-and-evaluation-with-frozen-section-samples
#2
Hong Yu, Feng Gao, Liren Jiang, Shuoxin Ma
BACKGROUND: The aim was to develop scalable Whole Slide Imaging (sWSI), a WSI system based on mainstream smartphones coupled with regular optical microscopes. This ultra-low-cost solution should offer diagnostic-ready imaging quality on par with standalone scanners, supporting both oil and dry objective lenses of different magnifications, and reasonably high throughput. These performance metrics should be evaluated by expert pathologists and match those of high-end scanners. OBJECTIVE: The aim was to develop scalable Whole Slide Imaging (sWSI), a whole slide imaging system based on smartphones coupled with optical microscopes...
September 15, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28916034/colorimetric-biosensor-based-on-a-dnazyme-primer-and-its-application-in-logic-gate-operations-for-dna-screening
#3
Chenguang Wang, Nan Cheng, Longjiao Zhu, Yuancong Xu, Kunlun Huang, Pengyu Zhu, Shuifang Zhu, Wei Fu, Wentao Xu
A colorimetric biosensor for DNA screening was designed based on the conformational changes of the horseradish peroxidase (HRP)-mimicking DNAzyme. The scheme of DNA biosensing was designed based on the base pairing of DNAzyme sequence to inhibit the formation of HRP-mimicking hemin/G-quadruplex structures in the process of amplification. DNA could be amplified via the universal primer multiplex polymerase chain reaction (UP-M-PCR) and innovatively detected as color disappear in the reaction visible to the naked eye...
September 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28912962/gene-panel-sequencing-in-brazilian-patients-with-retinitis-pigmentosa
#4
Kárita Antunes Costa, Mariana Vallim Salles, Chris Whitebirch, John Chiang, Juliana Maria Ferraz Sallum
BACKGROUND: Retinal dystrophies constitute a group of diseases characterized by clinical variability and pronounced genetic heterogeneity. Retinitis pigmentosa is the most common subtype of hereditary retinal dystrophy and is characterized by a progressive loss of peripheral field vision (Tunnel Vision), eventual loss of central vision, and progressive night blindness. The characteristics of the fundus changes include bone-spicule formations, attenuated blood vessels, reduced and/or abnormal electroretinograms, changes in structure imaged by optical coherence tomography, and subjective changes in visual function...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28912892/real-time-in-vivo-diagnosis-of-nasopharyngeal-carcinoma-using-rapid-fiber-optic-raman-spectroscopy
#5
Kan Lin, Wei Zheng, Chwee Ming Lim, Zhiwei Huang
We report the utility of a simultaneous fingerprint (FP) (i.e., 800-1800 cm(-1)) and high-wavenumber (HW) (i.e., 2800-3600 cm(-1)) fiber-optic Raman spectroscopy developed for real-time in vivo diagnosis of nasopharyngeal carcinoma (NPC) at endoscopy. A total of 3731 high-quality in vivo FP/HW Raman spectra (normal=1765; cancer=1966) were acquired in real-time from 204 tissue sites (normal=95; cancer=109) of 95 subjects (normal=57; cancer=38) undergoing endoscopic examination. FP/HW Raman spectra differ significantly between normal and cancerous nasopharyngeal tissues that could be attributed to changes of proteins, lipids, nucleic acids, and the bound water content in NPC...
2017: Theranostics
https://www.readbyqxmd.com/read/28905541/the-role-of-new-imaging-methods-in-managing-age-related-macular-degeneration
#6
Stephen James Talks, Akhunzada Muhammad Aftab, Imran Ashfaq, Taha Soomro
The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information this provides. For nonneovascular AMD high-resolution optical coherence tomography (OCT), autofluorescence, and near infrared imaging can identify the type of drusen, such as reticular pseudodrusen, which influences prognosis, and the amount of atrophy, for which phase 3 trials are underway...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905116/-teledermoscopy-by-mobile-phones-reliable-help-in-the-diagnosis-of-skin-lesions
#7
A Zink, A Kolbinger, M Leibl, I Léon Suarez, J Gloning, C Merkel, J Winkler, T Biedermann, J Ring, B Eberlein
BACKGROUND: Teledermoscopy is a promising modern technique to complement or to substitute dermatologic examination. OBJECTIVE: In this pilot study, we compared the outcomes of teledermoscopic consultations with clinical examinations and histologic results. METHODS: Conventional and dermatoscopic photos of single lesions were taken in 26 patients using a mobile phone and an attached handyscope optical system. Five resident physicians performed a clinical examination including dermoscopy while the teledermatologic and teledermoscopic photos were assessed by an experienced dermatologist...
September 13, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28902340/venous-loop-reveals-an-occult-retinoblastoma-tumor
#8
Katy C Liu, Scott D Walter, Avni P Finn, Miguel A Materin
A 14-day-old girl presented with bilateral hereditary retinoblastoma. At 3 months, a slight bend in the superotemporal arcade was observed to have developed into a venous loop. With concern for an occult lesion along the arcade, handheld optical coherence tomography (hhOCT) confirmed a small tumor and helped to guide prompt laser treatment while sparing the venous arcade. A venous loop is a previously unrecognized clinical finding that preceded the clinical detection and hhOCT confirmation of the tumor. The authors hypothesize that the venous loop was induced by pro-angiogenic factors secreted by the tumor...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28902169/whispering-gallery-mode-resonators-for-detecting-cancer
#9
REVIEW
Weeratouch Pongruengkiat, Suejit Pechprasarn
Optical resonators are sensors well known for their high sensitivity and fast response time. These sensors have a wide range of applications, including in the biomedical fields, and cancer detection is one such promising application. Sensor diagnosis currently has many limitations, such as being expensive, highly invasive, and time-consuming. New developments are welcomed to overcome these limitations. Optical resonators have high sensitivity, which enable medical testing to detect disease in the early stage...
September 13, 2017: Sensors
https://www.readbyqxmd.com/read/28902016/raman-microscopy-a-noninvasive-method-to-visualize-the-localizations-of-biomolecules-in-the-cornea
#10
Yuichi Kaji, Toshihiro Akiyama, Hiroki Segawa, Tetsuro Oshika, Hideaki Kano
PURPOSE: In vivo and in situ visualization of biomolecules without pretreatment will be important for diagnosis and treatment of ocular disorders in the future. Recently, multiphoton microscopy, based on the nonlinear interactions between molecules and photons, has been applied to reveal the localizations of various molecules in tissues. We aimed to use multimodal multiphoton microscopy to visualize the localizations of specific biomolecules in rat corneas. METHODS: Multiphoton images of the corneas were obtained from nonlinear signals of coherent anti-Stokes Raman scattering, third-order sum frequency generation, and second-harmonic generation...
September 7, 2017: Cornea
https://www.readbyqxmd.com/read/28901406/fgfr2-mutations-and-associated-clinical-observations-in-two-chinese-patients-with-crouzon-syndrome
#11
Ying Lin, Hongbin Gao, Siming Ai, Jacob V P Eswarakumar, Yi Zhu, Chuan Chen, Tao Li, Bingqian Liu, Hongye Jiang, Yuhua Liu, Yonghao Li, Qingxiu Wu, Haichun Li, Xiaoling Liang, Chenjin Jin, Xinhua Huang, Lin Lu
The aim of the present study was to identify mutations in the fibroblast growth factor receptor 2 (FGFR2) gene in patients with Crouzon syndrome and characterize the associated clinical features. A total of two Chinese patients diagnosed with Crouzon syndrome underwent complete examinations, including best‑corrected visual acuity, slit‑lamp, examination, fundus examination, optical coherence tomography and computed tomography of the skull. Genomic DNA was extracted from peripheral blood samples collected from the patients, as well as their family members and 200 unrelated control subjects from the same population...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900607/de-novo-intraocular-amyloid-deposition-after-hepatic-transplantation-in-familial-amyloidotic-polyneuropathy
#12
Ivo Filipe Gama, Leonor Duarte Almeida
The familiar amyloid polyneuropathy (FAP) is a rare autosomal-dominant systemic amyloidosis. Amyloid deposition occurs more frequently and extensively in the vitq. The increase in intraocular pressure (IOP) is a result of deposition of transthyretin (TTR) in trabecular meshwork. Rarely, the amyloid deposition in anterior segment can be more exuberant than in posterior segment. A 42 years old man, with FAP (Val30Met mutation), liver transplantation in 1997. He was asymptomatic, without any significant ocular abnormality until 2011...
August 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28899635/fast-technique-for-the-identification-of-gilbertella-persicaria-via-optical-microscopy
#13
Isabel Cruz-Lachica, Isidro Marquez-Zequera, Raul Allende-Molar, Josefa Adriana Sañudo-Barajas, Josefina Leon-Felix, Raymundo Saul Garcia-Estrada
Gilbertella persicaria is an important phytopathogen that is confused with Mucor spp. and Rhizopus spp. The main distinguishing characteristic of G. persicaria is the presence of appendages in sporangiospores, and their observation by conventional staining techniques generally fails. A technique is described using light microscopy for fast and reliable diagnosis.
September 9, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28898572/ratiometric-optical-imaging-of-subclinical-inflammation-with-a-thrombin-cleavable-probe-a-future-tool-for-the-in-vivo-visualization-of-clinically-silent-synovitis
#14
EDITORIAL
Katalin Mikecz
It is universally accepted that effective treatment of rheumatoid arthritis (RA) requires initiation of therapy at the early phase of articular inflammation. In addition to clinical and serological assessments, imaging of joint tissues provides useful information for the early diagnosis of RA (1). Although radiographic (X-ray) imaging can be used to detect bone erosions and to monitor disease progression in terms of bone involvement, X-ray does not detect early synovitis. This article is protected by copyright...
September 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28895765/prevalence-and-incidence-of-optic-neuritis-in-patients-with-different-types-of-uveitis
#15
Dianlin Guo, John Liu, Ran Gao, Samir Tari, Syed Islam
PURPOSE: This database study aims to investigate the incidence and prevalence of optic neuritis (ON) among patients with different types of uveitis. METHODS: A retrospective analysis of the Truven Health MarketScan® database from 2000 to 2014 was conducted. Patients with uveitis were followed until diagnosis of ON or until they were censored. Diagnosis of uveitis and demyelinating diseases of the central nervous system (DD) including ON were based on ICD-9 codes...
September 12, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28895667/a-review-through-the-looking-glass-new-advances-in-dermoscopy
#16
Brady Bleicher, Amanda Levine, Michelle Schwartz, Orit Markowitz
Dermoscopy is a non-invasive diagnostic technique that facilitates the visualization of surface and subsurface structures of the skin. It has been proven to be an essential tool in the diagnosis of both malignant and benign cutaneous lesions. In this article, we review some of the most recent and noteworthy advances in dermoscopy. In addition, we discuss Reflectance Confocal Microscopy (RCM) and Optical Coherence Topography (OCT), two non-invasive imaging devices that may be used alongside dermoscopy to improve diagnostic accuracy...
September 12, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28893456/-rare-causes-of-childhood-leukocoria
#17
J-P Diagne, A S Sow, A M Ka, A M Wane, P A Ndoye Roth, E A Ba, M E De Medeiros, J M Ndiaye, H M Diallo, H Kane, S Sow, M Nguer, E M Sy, P A Ndiaye
PURPOSE: The purpose was to record the causes of leukocoria among children under 10years of age and to determine the proportion of rare causes of leukocoria. PATIENTS AND METHODS: This retrospective study was conducted over a period of ten years, from January 1, 2004 to December 31, 2013, in patients under 10years of age who were referred for leukocoria. RESULTS: Leukocoria represented one of the ten reasons for consultation among children under 10years of age...
September 8, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28890078/choroidal-thinning-associated-with-hydroxychloroquine-retinopathy
#18
Seong Joon Ahn, So Jung Ryu, Joo Young Joung, Byung Ro Lee
PURPOSE: To investigate choroidal thickness in patients using hydroxychloroquine (HCQ) and compare choroidal thickness between eyes with and without HCQ retinopathy. DESIGN: Retrospective case series METHODS: Setting: Institutional Patients: We included 124 patients with systemic lupus erythematosus or rheumatoid arthritis who were treated with HCQ. The patients were divided into an HCQ retinopathy group and a control group, according to the presence or absence of HCQ retinopathy...
September 7, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28888177/a-label-free-cardiac-biomarker-immunosensor-based-on-phase-shifted-microfiber-bragg-grating
#19
Tong Liu, Li-Li Liang, Peng Xiao, Li-Peng Sun, Yun-Yun Huang, Yang Ran, Long Jin, Bai-Ou Guan
Fiber optics evanescent field based biosensor is an excellent candidate for label-free detection of cardiac biomarkers which is of great importance in rapid, early, and accurate diagnosis of acute myocardial infarction (AMI). In this paper, we report a compact and sensitive cardiac troponin I (cTn-I) immunosensor based on the phase-shifted microfiber Bragg grating probe which is functionalized. The fine reflective signal induced by the phase shift in modulation significantly improves the spectral resolution, enabling the ability of the sensor in perceiving an ultra-small refractive index change due to the specific capture of the cTn-I antigens...
September 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28887783/a-novel-integration-of-spectral-domain-optical-coherence-tomography-and-laser-ablation-system-for-precision-treatment
#20
Yingwei Fan, Boyu Zhang, Wei Chang, Xinran Zhang, Hongen Liao
PURPOSE: Complete resection of diseased lesions reduces the recurrence of cancer, making it critical for surgical treatment. However, precisely resecting residual tumors is a challenge during operation. A novel integrated spectral-domain optical-coherence-tomography (SD-OCT) and laser-ablation therapy system for soft-biological-tissue resection is proposed. This is a prototype optical integrated diagnosis and therapeutic system as well as an optical theranostics system. METHODS: We develop an optical theranostics system, which integrates SD-OCT, a laser-ablation unit, and an automatic scanning platform...
September 9, 2017: International Journal of Computer Assisted Radiology and Surgery
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