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epithelial misplacement

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https://www.readbyqxmd.com/read/27676454/challenging-diagnostic-issues-in-adenomatous-polyps-with-epithelial-misplacement-in-bowel-cancer-screening-5-years-experience-of-the-bowel-cancer-screening-programme-expert-board
#1
Rebecca K L Griggs, Marco R Novelli, D Scott A Sanders, Bryan F Warren, Geraint T Williams, Philip Quirke, Neil A Shepherd
The diagnostic difficulties of differentiating epithelial misplacement from invasive cancer in colorectal adenomatous polyps have been recognised for many years. Nevertheless, the introduction of population screening in the UK has resulted in extraordinary diagnostic problems. Larger sigmoid colonic adenomatous polyps, which are those most likely to show epithelial misplacement, are specifically selected into such screening programmes, because these polyps are likely to bleed and screening is based on the detection of occult blood...
September 27, 2016: Histopathology
https://www.readbyqxmd.com/read/27474044/thyroid-like-follicular-carcinoma-of-the-kidney-an-emerging-renal-neoplasm-with-curiously-misplaced-histologic-features-a-case-report
#2
Matthew J Muscara, Novae B Simper, Edwin Gandia
Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare but emerging renal neoplasm that morphologically mimics follicular carcinoma of the thyroid but lacks immunohistochemical expression of thyroid markers such as TTF-1 and thyroglobulin. Here, a case of an incidentally discovered TLFCK in a 27-year-old man is reported. Histologic evaluation demonstrated an encapsulated proliferation of variably sized thyroid follicle-like epithelial-lined spaces filled with colloid-like eosinophilic secretions...
July 29, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27336173/alix-mediated-assembly-of-the-actomyosin-tight-junction-polarity-complex-preserves-epithelial-polarity-and-epithelial-barrier
#3
Yvan Campos, Xiaohui Qiu, Elida Gomero, Randall Wakefield, Linda Horner, Wojciech Brutkowski, Young-Goo Han, David Solecki, Sharon Frase, Antonella Bongiovanni, Alessandra d'Azzo
Maintenance of epithelial cell polarity and epithelial barrier relies on the spatial organization of the actin cytoskeleton and proper positioning/assembly of intercellular junctions. However, how these processes are regulated is poorly understood. Here we reveal a key role for the multifunctional protein Alix in both processes. In a knockout mouse model of Alix, we identified overt structural changes in the epithelium of the choroid plexus and in the ependyma, such as asymmetrical cell shape and size, misplacement and abnormal beating of cilia, blebbing of the microvilli...
June 23, 2016: Nature Communications
https://www.readbyqxmd.com/read/26975041/diagnostic-challenges-caused-by-endoscopic-biopsy-of-colonic-polyps-a-systematic-evaluation-of-epithelial-misplacement-with-review-of-problematic-polyps-from-the-bowel-cancer-screening-program-united-kingdom
#4
Nicole C Panarelli, Thusitha Somarathna, Wade S Samowitz, Susan Kornacki, Scott A Sanders, Marco R Novelli, Neil A Shepherd, Rhonda K Yantiss
Endoscopic mucosal biopsy may misplace mucosal elements into the submucosa of colonic adenomas, mimicking invasive adenocarcinoma. Biopsy-related misplacement can be more challenging to recognize than typical misplaced epithelium (pseudoinvasion) in pedunculated polyps. We compared the features of 16 polyps with biopsy-related misplaced epithelium with those of 10 adenomas with pseudoinvasion and 10 adenomas with invasive adenocarcinoma and performed Ki67 and p53 immunostaining on all cases. Features of misplaced epithelium in polyps referred to the Bowel Cancer Screening Program Expert Board in the United Kingdom were also evaluated for the same morphologic features...
August 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26888398/-epithelial-misplacement-with-high-grade-dysplasia-in-a-colonic-adenoma-report-of-a-case
#5
Shuchen Xiong, Xinhua Yue, Zhanguo Nie, Haihua Zhao, Li Ma, Xinping Tang, Yuan Xiang, Yulan Wang
No abstract text is available yet for this article.
November 2015: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/26414404/lateral-adhesion-drives-reintegration-of-misplaced-cells-into-epithelial-monolayers
#6
Dan T Bergstralh, Holly E Lovegrove, Daniel St Johnston
Cells in simple epithelia orient their mitotic spindles in the plane of the epithelium so that both daughter cells are born within the epithelial sheet. This is assumed to be important to maintain epithelial integrity and prevent hyperplasia, because misaligned divisions give rise to cells outside the epithelium. Here we test this assumption in three types of Drosophila epithelium; the cuboidal follicle epithelium, the columnar early embryonic ectoderm, and the pseudostratified neuroepithelium. Ectopic expression of Inscuteable in these tissues reorients mitotic spindles, resulting in one daughter cell being born outside the epithelial layer...
November 2015: Nature Cell Biology
https://www.readbyqxmd.com/read/25560603/bowel-cancer-screening-generated-diagnostic-conundrum-of-the-century-pseudoinvasion-in-sigmoid-colonic-polyps
#7
REVIEW
Neil A Shepherd, Rebecca K L Griggs
The introduction of bowel cancer screening, in the United Kingdom, United States of America, and many other Western countries, has provided considerable interest and no little diagnostic consternation for pathologists. In the United Kingdom, the universal introduction of bowel cancer screening, initially by fecal occult blood testing and more recently by the introduction of flexible sigmoidoscopy, has provided four main areas of pathological diagnostic difficulty. This is the biopsy diagnosis of adenocarcinoma, serrated pathology, the diagnosis and management of polyp cancer, and, finally, the phenomenon of pseudoinvasion/epithelial misplacement (PEM), particularly in sigmoid colonic adenomatous polyps...
January 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/25307411/colitis-cystica-profunda-indefinite-for-dysplasia-in-crohn-disease-a-potential-diagnostic-pitfall
#8
Juan Carlos Hernandez-Prera, Alexandros D Polydorides
Colitis cystica profunda (CCP) is a nonneoplastic condition characterized by misplaced glands deep to the muscularis mucosae of the colon and may be difficult to differentiate from well-differentiated mucinous adenocarcinoma. Absence of dysplasia in CCP usually aids in this distinction. We present a challenging case of CCP in the setting of Crohn disease (CD) containing foci of atypical epithelium. A right hemicolectomy from a 46-year-old woman contained a stricture associated with a proximal multilocular cystic lesion containing mucin-filled glands dissecting through the colonic wall...
December 2014: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25123305/the-pathology-of-bowel-cancer-screening
#9
REVIEW
Maurice B Loughrey, Neil A Shepherd
Colorectal cancer screening is widely promulgated in many parts of the world and population screening is occurring in many countries, especially in western Europe. Although, intuitively, it might be thought that the pathology resulting from screening should be straightforward, being mainly that of polyp diagnosis and the biopsy diagnosis and staging of established adenocarcinoma, in fact experience has shown that there are several areas of considerable difficulty and controversy. In the UK somewhat different programmes, all based on faecal occult blood (FOB) screening, have been developed and each has generated similar pathological conundra...
January 2015: Histopathology
https://www.readbyqxmd.com/read/24973733/regulation-and-pathophysiological-role-of-epithelial-turnover-in-the-gut
#10
Claudia Günther, Barbara Buchen, Markus F Neurath, Christoph Becker
Cell death in the intestinal epithelium has to be tightly controlled. Excessive or misplaced epithelial cell death can result in barrier dysfunction and, as a consequence thereof, uncontrolled translocation of components of the microbial flora from the lumen into the bowel wall. Susceptibility to gastrointestinal infections or chronic inflammation of the gut, as observed in patients with inflammatory bowel disease, can be the result of such dysregulation. Conversely, defects in cell death initiation might lead to an irregular accumulation of epithelial cells and cause intestinal cancer development...
November 2014: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/23837011/current-concepts-and-occurrence-of-epithelial-odontogenic-tumors-i-ameloblastoma-and-adenomatoid-odontogenic-tumor
#11
Suk Keun Lee, Yeon Sook Kim
Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke's pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively...
June 2013: Korean Journal of Pathology
https://www.readbyqxmd.com/read/23741988/invasive-cancers-are-not-necessarily-from-preformed-in-situ-tumours-an-alternative-way-of-carcinogenesis-from-misplaced-stem-cells
#12
Rui-An Wang, Zeng-Shan Li, Hui-Zhong Zhang, Ping-Ju Zheng, Qin-Long Li, Jian-Guo Shi, Qing-Guo Yan, Jing Ye, Jing-Bo Wang, Ying Guo, Xiao-Feng Huang, Ying-Hao Yu
Cancers are thought to be the result of accumulated gene mutations in cells. Carcinomas, which are cancers arising from epithelial tissues usually go through several stages of development: atypical hyperplasia, carcinoma in situ and then invasive carcinoma, which might further metastasize. However, we think that the present pathological data are enough to prove that there might be an alternative way of carcinogenesis. We propose that majority of invasive cancers arise in the connective tissue stroma de novo, from the misplaced epithelial stem cells which come to the wrong land of connective tissue stroma by accident...
July 2013: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/23611360/interobserver-agreement-in-the-reporting-of-colorectal-polyp-pathology-among-bowel-cancer-screening-pathologists-in-wales
#13
Jeff K Turner, Geraint T Williams, Meleri Morgan, Melissa Wright, Sunil Dolwani
AIMS: To assess the interobserver agreement in the reporting of colorectal polyps among histopathologists participating in the Welsh Bowel Cancer Screening (BCS) programme. METHODS AND RESULTS: Twelve benign polyps representative of BCS cases were identified from pathology files and reported by 28 BCS histopathologists using proforma sheets. The level of agreement between the participants and a gold standard was determined using kappa (κ) statistics. A moderate level of agreement was achieved in the reporting of polyp type [κ = 0...
May 2013: Histopathology
https://www.readbyqxmd.com/read/23530564/vascular-pseudoinvasion-in-a-solitary-peutz-jeghers-polyp-in-the-ileum
#14
Haruka Okada, Shingo Itagaki, Kazuaki Enatsu, Takahiro Kiriu, Mitsugu Ishizawa
A Peutz-Jeghers polyp (PJP) is a hamartomatous lesion characterized by arborescent smooth muscle bundles covered with mucosa native to the site of involvement. PJPs in the small intestine may represent misplacement of non-neoplastic epithelium into the submucosa, muscularis propria and subserosa. Although epithelial misplacement in PJPs is a well-documented phenomenon, pseudoinvasion even into the vascular space in PJPs has not previously been reported. We report a case of a 22-year-old Japanese woman with a solitary PJP in the ileum...
March 2013: Pathology International
https://www.readbyqxmd.com/read/23361253/-tumor-in-the-small-intestine-in-peutz-jeghers-syndrome
#15
J Friemel, Z Varga, A Weber
Epithelial misplacement can be present in small bowel polyps of patients with Peutz-Jeghers syndrome and can mimic invasive malignancy. For recognizing epithelial misplacement, which can also have dysplastic changes, it is helpful to demonstrate the associated lamina propria and the lack of desmoplastic response. Intramural mucinous cysts are frequently seen in the setting of epithelial misplacement.
March 2013: Der Pathologe
https://www.readbyqxmd.com/read/23227010/identification-of-displaced-endometrial-glands-and-embryonic-duct-remnants-in-female-fetal-reproductive-tract-possible-pathogenetic-role-in-endometriotic-and-pelvic-neoplastic-processes
#16
Jean Bouquet de Jolinière, Jean Marc Ayoubi, Guy Lesec, Pierre Validire, Alexandre Goguin, Luca Gianaroli, Jean Bernard Dubuisson, Anis Feki, Jean Gogusev
BACKGROUND: Recent findings strongly promoted the hypothesis that common pelvic gynecological diseases including endometriosis and ovarian neoplasia may develop de novo from ectopic endometrial-like glands and/or embryonic epithelial remnants. To verify the frequency, the anatomical localization and the phenotype of misplaced endometrial tissue along the fetal female reproductive tract, histological and immunohistochemical analyses of uteri, fallopian tubes, and uterosacral ligaments were performed...
2012: Frontiers in Physiology
https://www.readbyqxmd.com/read/23121028/pseudotumors-and-mimickers-of-malignancy-of-the-head-and-neck-pathology
#17
REVIEW
M Michal, D Kacerovská, D V Kazakov, A Skálová
We are summarizing some of the difficult pitfalls in tumors of the head and neck, which we have encountered in our biopsies referred for consultation as well as from our routine praxis in the last 20 years. Shortly we are presenting the following lesions of head and neck: multifocal sclerosing thyroiditis, mucoepidermoid carcinoma of the thyroid, solid cell nests, Chievitz organ, rhomboid glossitis, ectopic parathyroid, signet ring cell change of salivary glands, mucocele, epithelial misplacement of the vocal cord squamous cell epithelium, and angiomatoid nasal polyps...
October 2012: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/21979599/misplaced-skene-s-glands-glandular-elements-in-the-lower-female-genital-tract-that-are-variably-immunoreactive-with-prostate-markers-and-that-encompass-vaginal-tubulosquamous-polyp-and-cervical-ectopic-prostatic-tissue
#18
Paul Kelly, Hilary A McBride, Kathryn Kennedy, Lynette E Connolly, W Glenn McCluggage
So-called ectopic prostatic tissue in the cervix and vaginal tubulosquamous polyps are rare morphologically similar lesions that may show positive immunohistochemical staining with prostatic markers. It has been suggested that they are related to paraurethral Skene's glands that are the female equivalent of prostatic glands in the male. We report a large series of lesions in women aged 23 to 81 years, found within the cervix (n=24), vagina (n=10), and vulva (n=2), which we believe to be a part of a spectrum of lesions derived from Skene's glands, either eutopic or more commonly misplaced during embryonic development...
November 2011: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/21836475/iatrogenic-deep-epithelial-misplacement-gastritis-cystica-profunda-in-a-gastric-foveolar-type-adenoma-after-endoscopic-manipulation-a-diagnostic-pitfall
#19
Godman Greywoode, Aron Szuts, Lai Mun Wang, Bruno Sgromo, Runjan Chetty
Gastritis cystica profunda (GCP) is analogous to the more commonly encountered colitis cystic profunda. Both conditions are associated with polypoid and/or ulcerative mucosal lesions with or without previous surgery. Typically, the misplaced glands in GCP are encountered in the submucosa. The case described occurred in a 62-year-old man with a fundic foveolar adenoma containing foci of low-grade dysplasia. Three attempts at endoscopic removal were attempted before a sleeve gastrectomy was performed. Remnants of the foveolar adenoma were identified in the resection specimen...
September 2011: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/21203493/thymus-associated-parathyroid-hormone-has-two-cellular-origins-with-distinct-endocrine-and-immunological-functions
#20
Zhijie Liu, Alison Farley, Lizhen Chen, Beth J Kirby, Christopher S Kovacs, C Clare Blackburn, Nancy R Manley
In mammals, parathyroid hormone (PTH) is a key regulator of extracellular calcium and inorganic phosphorus homeostasis. Although the parathyroid glands were thought to be the only source of PTH, extra-parathyroid PTH production in the thymus, which shares a common origin with parathyroids during organogenesis, has been proposed to provide an auxiliary source of PTH, resulting in a higher than expected survival rate for aparathyroid Gcm2⁻/⁻ mutants. However, the developmental ontogeny and cellular identity of these "thymic" PTH-expressing cells is unknown...
2010: PLoS Genetics
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