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Mansour Moghimi, Fatemeh Joukar, Amin Salehi-Abargouei, Mohammad-Reza Mozayan, Amir Aryanfar
Perineural invasion (PNI) is characterized as tumoral or nontumoral cells invading in or around the nerves. The neural invasion is considered as a histopathologic characteristic for malignancy and is considered a mechanism for its spread. Both of these patterns usually portend a poor prognosis and very often are markers to prompt additional treatment. There are also some nonmalignancies representing PNI, including benign neoplasms, mimicking lesions, and disorders, such as chronic pancreatitis and endometriosis...
March 2017: Advances in Anatomic Pathology
Eelco C Brand, Raouf E Nakhleh, Michael B Wallace
No abstract text is available yet for this article.
August 22, 2016: Gastrointestinal Endoscopy
Toru Sakatani, Yasushi Adachi, Noriko Sakaida, Takeshi Atsuta, Toshihiro Magaribuchi, Yoji Taki, Yorika Nakano, Ming Li, Susumu Ikehara
Nephrogenic adenoma (NA), referred to as nephrogenic metaplasia, is a rare benign lesion of the urinary tract. NA is histologically characterized by tubular and papillary formations lined by low cuboidal to columnar epithelial cells. NA is also immunohistochemically characterized by positivity for paired box (PAX) 2, PAX8 and cytokeratin 7, and negative for p63 and prostate-specific antigen. In this study, we present 3 cases of NA arising in the urinary bladder of elderly male patients with predisposing factors: patient 1 had undergone transurethral lithotripsy due to a ureteral stone; patient 2 had undergone transurethral resection of a urothelial carcinoma in the urinary bladder; and patient 3 had been treated with Bacillus-Calmettle-Guérin due to a urothelial carcinoma in the urinary bladder...
August 2016: Molecular and Clinical Oncology
Nicole C Panarelli, Thusitha Somarathna, Wade S Samowitz, Susan Kornacki, Scott A Sanders, Marco R Novelli, Neil A Shepherd, Rhonda K Yantiss
Endoscopic mucosal biopsy may misplace mucosal elements into the submucosa of colonic adenomas, mimicking invasive adenocarcinoma. Biopsy-related misplacement can be more challenging to recognize than typical misplaced epithelium (pseudoinvasion) in pedunculated polyps. We compared the features of 16 polyps with biopsy-related misplaced epithelium with those of 10 adenomas with pseudoinvasion and 10 adenomas with invasive adenocarcinoma and performed Ki67 and p53 immunostaining on all cases. Features of misplaced epithelium in polyps referred to the Bowel Cancer Screening Program Expert Board in the United Kingdom were also evaluated for the same morphologic features...
August 2016: American Journal of Surgical Pathology
Maria João Ferreira da Silva, Rolando Pinho, Xiaogang Wen, David Tente, Sónia Leite, João Carvalho
No abstract text is available yet for this article.
February 2017: Gastroenterología y Hepatología
Hilary M DuBrock, Richard L Kradin, Josanna M Rodriguez-Lopez, Richard N Channick
Pulmonary capillary hemangiomatosis (PCH) is a rare form of pulmonary arterial hypertension (PAH) characterized by pulmonary capillary proliferation and pseudoinvasion of collagenous septal structures. PCH is often accompanied by veno-occlusive changes and pulmonary hypertensive arterial remodeling. The clinical and pathological diagnosis of PCH can be subtle and easily missed. Most reported cases of PCH have been associated with resting PAH. We report the cases of 3 patients who initially presented with exertional dyspnea with normal to mildly elevated resting pulmonary arterial pressures and marked intrapulmonary shunting...
September 2015: Pulmonary Circulation
Roka Namoto Matsubayashi, Seiya Momosaki, Toru Muranaka
PURPOSE: To investigate the imaging characteristics of rare ductal adenoma of the breast, we evaluated the detailed imaging findings and correlated them with the pathologic features of the ductal adenomas. In particular, we describe in detail the imaging findings derived from "pseudoinvasion," one of the histological features unique to this tumor. MATERIALS AND METHODS: We reviewed the imaging findings including magnetic resonance imaging (MRI) in three patients with ductal adenomas of the breast and correlated the findings with the detailed histological features...
July 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Neil A Shepherd, Rebecca K L Griggs
The introduction of bowel cancer screening, in the United Kingdom, United States of America, and many other Western countries, has provided considerable interest and no little diagnostic consternation for pathologists. In the United Kingdom, the universal introduction of bowel cancer screening, initially by fecal occult blood testing and more recently by the introduction of flexible sigmoidoscopy, has provided four main areas of pathological diagnostic difficulty. This is the biopsy diagnosis of adenocarcinoma, serrated pathology, the diagnosis and management of polyp cancer, and, finally, the phenomenon of pseudoinvasion/epithelial misplacement (PEM), particularly in sigmoid colonic adenomatous polyps...
January 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Joseph T Rabban, Poonam Vohra, Charles J Zaloudek
Mucosal alterations of the fallopian tube are generally thought to represent alterations of the native tubal mucosal epithelium, whether benign or malignant. The current paradigm implicating the fallopian tube fimbriae as the origin of most pelvic high-grade serous carcinomas (HGSCs) is based on the premise that HGSC growing within the tubal mucosa originated there. This has fueled proposals to redefine classification rules for assigning the primary site of origin on the basis of the presence or absence of HGSC in the tubal mucosa...
January 2015: American Journal of Surgical Pathology
A M Bronshteĭn, N A Malyshev, L V Fedianina, S N Zharov, A A Frolova
The paper describes cases of pseudoinvasion and transient carriageof the larvae of arthropods and geohelminths. It highlights the objective and subjective factors in the diagnosis of arthropod-borne diseases and geohelminthiasis, which give rise to misdiagnosis. Distinctions between real invasion, transient invasion, and pseudoinvasion are pointed out. The fact that there are special problems with the misdiagnosis of people with mental diseases is emphasized. The key factors for preventing and diagnosing pseudoinvasions and transient carriage are defined...
January 2014: Meditsinskaia Parazitologiia i Parazitarnye Bolezni
Chia-Sui Kao, Jonathan I Epstein
Tubular adenomas in the urinary tract with the same appearance as those in the gastrointestinal tract have not yet been described in the literature. We herein report 4 cases of tubular adenomas in the urinary tract encountered within our consult practice. This lesion was defined by the presence of a collection of small round tubular glands with intestinal-type epithelium showing moderate dysplasia, identical to the histology of tubular adenomas in the intestinal tract. Patients ranged in age from 37 to 63 years (mean, 45 years), with 3 of the 4 being male (male-to-female ratio, 3:1)...
September 2013: Human Pathology
Haruka Okada, Shingo Itagaki, Kazuaki Enatsu, Takahiro Kiriu, Mitsugu Ishizawa
A Peutz-Jeghers polyp (PJP) is a hamartomatous lesion characterized by arborescent smooth muscle bundles covered with mucosa native to the site of involvement. PJPs in the small intestine may represent misplacement of non-neoplastic epithelium into the submucosa, muscularis propria and subserosa. Although epithelial misplacement in PJPs is a well-documented phenomenon, pseudoinvasion even into the vascular space in PJPs has not previously been reported. We report a case of a 22-year-old Japanese woman with a solitary PJP in the ileum...
March 2013: Pathology International
Jinru Shia, David S Klimstra, Pelin Bagci, Olca Basturk, N Volkan Adsay
The TNM staging system of the American Joint Committee on Cancer and the Union for International Cancer Control provides the most reliable guidelines for the prognostication and treatment of colorectal carcinoma. However, issues and caveats exist in the application of this system, mostly relating to the definition of the staging parameters and the pathologic interpretation of the gross and microscopic findings of the resected specimens. This article highlights some of the major issues in both areas. First, it assesses the definition of selected staging parameters, including pTis, pT4a versus pT4b, tumor deposits/N1c, ypT/ypN, and the TNM for rectal versus anal carcinoma...
August 2012: Seminars in Diagnostic Pathology
Arlin B Rogers
Histopathology is a defining endpoint in mouse models of experimental gastritis and gastric adenocarcinoma. Presented here is an overview of the histology of gastritis and gastric cancer in mice experimentally infected with Helicobacter pylori or H. felis. A modular histopathologic scoring scheme is provided that incorporates relevant disease-associated changes. Whereas the guide uses Helicobacter infection as the prototype challenge, features may be applied to chemical and genetically engineered mouse models of stomach cancer as well...
2012: Methods in Molecular Biology
Fukuo Kondo
Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs). In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) the amount of fibrous components of stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation...
2011: International Journal of Hepatology
David P Boyle, W Glenn McCluggage
AIMS: To describe an unusual and hitherto unreported pseudoneoplastic phenomenon that is characterised by the entrapment of benign squamous epithelium following cervical loop excision or punch biopsy and that may mimic invasive squamous carcinoma. METHODS AND RESULTS: The authors report six cases in patients aged 25-45 years in whom benign squamous epithelium is incorporated within the cervical stroma as a result of the healing process following prior loop excision (four cases) or punch biopsy (two cases)...
December 2011: Journal of Clinical Pathology
Adriana Krizova, Blaise A Clarke, Marcus Q Bernardini, Sarah James, Steve E Kalloger, Scott L Boerner, Anna Marie Mulligan
Total laparoscopic hysterectomy (LH) is a minimally invasive technique, which results in comparable morbidity and better cosmesis compared with total abdominal hysterectomy. The literature is discrepant as to whether it is associated with a higher incidence of positive peritoneal cytology compared with total abdominal hysterectomy and recently, associated artifacts, including vascular pseudoinvasion (VPI), have been described. A retrospective histopathologic review of 266 hysterectomy specimens from 2 centers was performed...
January 2011: American Journal of Surgical Pathology
Ann K Folkins, Nicole S Nevadunsky, A Saleemuddin, Elke A Jarboe, Michael G Muto, Colleen M Feltmate, Chris P Crum, Michelle S Hirsch
Recent reports have described 'vascular pseudoinvasion' in total laparoscopic hysterectomies with endometrial carcinoma. To better understand this phenomenon, we compared pathologic findings in these laparoscopic and total abdominal hysterectomies performed for uterine endometrioid adenocarcinoma. Reports from 58 robotically assisted laparoscopic and 39 abdominal hysterectomies with grade 1 or 2 endometrioid endometrial adenocarcinomas were reviewed for stage, depth of invasion, vascular space involvement, uterine weight, and lymph node metastases...
August 2010: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Tae Jun Byun, Dong Soo Han, Sang Bong Ahn, Hyun Seok Cho, Chang Soo Eun, Yong Cheol Jeon, Joo Hyun Sohn, Young-Ha Oh
Pseudoinvasion or pseudocarcinomatous invasion in an adenomatous polyp of the colon can be unfamiliar to an endoscopist. Pseudoinvasion in an adenomatous polyp represents prolapse of the adenomatous epithelium into its stalk. In most cases its morphology does not differ from of general adenomatous polyps, but in some cases it can morphologically mimic a malignant polyp with submucosal invasion due to mass-like lesioning of its stalk. This makes it difficult for endoscopists to differentiate pseudoinvasion in an adenoma from an invasive carcinoma by conventional endoscopy; instead, endoscopic ultrasonography can provide useful information for differentiating these conditions...
June 2009: Gut and Liver
Fukuo Kondo
Based on clinical and pathological experience, indistinct margin-type hepatocellular carcinomas (HCCs) were considered to be typical early-stage HCCs with good prognosis. For histological diagnosis, the assessment of stromal invasion (tumor invasion into portal tracts and fibrous septa) is very important. In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in the fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) amount of fibrous components of the stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation...
March 2009: Hepatology International
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