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Juliana Elaine Perobelli
Nowadays, the advances in knowledge about oncologic treatment have led to an increase in survival rate for cancer patients and, consequently, a growing concern about the adverse effects of treatment in medium and long term, in order to ensure the future quality of life. For male patients in reproductive age or younger, one of the key concerns after cancer therapy is their ability to father children, since anticancer drugs exert cytotoxic effects on germ cells. Considering the incidence of cancer in children and adolescents and the vulnerability of these developmental phases to chemical injuries, this review is an attempt to highlight the importance of juvenile experimental models to test new anticancer drugs and agents with protective action...
2017: Anti-cancer Agents in Medicinal Chemistry
Sara Bañón, Isabel Machuca, Susana Araujo, Ana Moreno, María J Perez-Elías, Santiago Moreno, Jose Luis Casado
INTRODUCTION: Concomitant use of combination antiretroviral regimen (cART) and cancer chemotherapy is difficult due to complex interactions and increased toxicity. Raltegravir could be an adequate option through its favourable drug-drug interaction profile. METHODS: Prospective longitudinal study of HIV patients with cancer, AIDS related or not, undergoing chemotherapy. Patients without resistance or previous failure were switched or initiated raltegravir plus two nucleoside analogues...
2014: Journal of the International AIDS Society
Giuseppe Todeschini, Massimiliano Bonifacio, Cristina Tecchio, Rita Balter, Giuseppe Carli, Piero Maria Stefani, Fausto Adami, Alberto Zamò, Angelo Paolo Dei Tos, Filippo Marino, Filippo Gherlinzoni, Pierluigi Marradi, Giampietro Semenzato, Giovanni Pizzolo
The optimal treatment of advanced sporadic Burkitt lymphoma in adults is still a matter of debate. The salutary results of pediatric therapies did open the road for improving the adult outcome. Between May 1988 and March 2009, 71 consecutive patients-46 adults, 25 children-affected by Burkitt lymphoma/leukemia were treated with the same intensive pediatric protocol alternating vincristine, adriamycine and fractionated ciclophosphamide (phase A) with high dose methotrexate and high dose cytarabine (phase B) in four Italian institutions...
January 2012: American Journal of Hematology
Inmaculada Macías Fernández
Male with diagnosis of Wegener's granulomatosis associated to anti-proteinase 3 antibodies that improved initially to the treatment with high dose glucocorticoids and ciclophosphamide, but in a relapse he did not have good response to glucocorticoid treatment, ciclophosphamide, methotrexate nor azathioprine. The patient received treatment with rituximab in 4 doses with clinical and radiographic improvement.
January 2010: Reumatología Clinica
Franck Verrecchia, Ying Wang, Lavinia Vija, Dominique Farge
This review aims to present how a better understanding of the pathogenesis of tissue fibrosis and of the pivotal role of extracellular matrix components supports the use of various immunosuppressive drugs to treat systemic sclerosis (SSc). Recent experimental data demonstrating the antifibrotic effect of several immunosuppressive drugs, independently of their immunosuppressive action, must be put into context with the clinical results observed in immunosuppressed SSc patients. Ciclophosphamide is now considered the drug of choice for interstitial lung disease in SSc and in rapidly progressive diffuse SSc...
January 2009: Expert Review of Clinical Immunology
R Ramos, R Poveda, C Bernís, J Ara, M Sunyer, P Arrizabalaga, J M Grinyó
Renal involvement is observed frequently in association with malignant gammopathies, mainly those related to light chain deposition, although has also been described in non-malignant monoclonal gammopathy. This study reports the clinicopathological findings and outcome in 9 patients with nephropaty secondary to monoclonal immunoglobulin deposit in absence of malignancy. They were three men and six women and they were 59.2+/-12 years old. All patients presented proteinuria and different levels of renal insufficiency (mean creatinin = 315+/-187 micromol/L) at the moment of diagnostic...
2008: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Dan Hristea, Karine Hadaya, Nicola Marangon, Léo Buhler, Jean Villard, Philippe Morel, Pierre-Yves Martin
A 22-year-old patient whose primary kidney disease was focal segmental glomerulosclerosis (FSGS) developed severe recurrence of proteinuria (up to 57 g/24 h) immediately after a haploidentic living donor kidney transplantation despite pre-operative plasmapheresis. The immunosuppressive treatment consisted of tacrolimus, mycophenolate mofetil, basiliximab and steroids. He underwent 10 plasmapheresis sessions in the first 3-week post-transplantation. In addition, he received 2 i.v. doses of rituximab (RTX) 600 mg (375 mg/m(2)) on days 7 and 15...
January 2007: Transplant International: Official Journal of the European Society for Organ Transplantation
Nzi André Konan, Elfriede Marianne Bacchi, Nilton Lincopan, Soraya Duarte Varela, Eliana Aparecida Varanda
Anacardium occidentale L. (Anacardiaceae), popularly known as cajueiro is a native plant to Brazil, and largely used in popular medicine to treat ulcers, hypertension and diarrhea. In the present study, acute, 30-day subacute toxicity and genotoxicity assays were carried out. The crude extract did not produce toxic symptoms in rats in doses up to 2000 mg/kg. Based on biochemical analyses of renal and hepato-biliary functions, such as the level of urea, creatinine, transaminases and alkaline phosphatase, we determined that the extract is generally tolerated by rats...
March 1, 2007: Journal of Ethnopharmacology
C Damas, G Fernandes, A Magalhães, V P Hespanhol
Male, 54 years old, with smoking habits. The patient complaints were cough, with bleeding secretions in the previous two months. Because of the persistence of the symptoms, a bronchoscopy was proposed. This exam showed multiple lesions in the trachea, nearly 2 cm above the vocal cords that compromised the airway and did not allow the progression of the bronchoscope. For this reason, it was decided to introduce a tracheal prosthesis. Because of instability, and the suspicion of malignancy we started thoracic irradiation...
May 2006: Revista Portuguesa de Pneumologia
Davide Tassinari, Giovenzio Genestreti, Enzo Pasquini, Manuela Fantini, Barbara Poggi, Emiliano Tamburini, Maximilian Papi, Giorgio Ioli, Giovanni Oliverio, Francesca Fochessati, Valentina Arcangeli, Vanessa Agostini, Anna Maria Mianulli, Manuela Imola, Pier Paolo Fattori, Alberto Ravaioli
Although cisplatin and etoposide seem to represent the treatment of choice in Small-Cell Lung Cancer, a lot of data exist in literature supporting both the use of anthracycline-containing regimens and the use of alternating regimens where platinum-containing regimens and anthracycline-containing regimens are alternatively used as first line in the same patient. In our paper we review the outcomes of two different series of patients treated with ciclophosphamide-epidoxorubicin-etoposide (CEVP16) or carboplatin-etoposide (CBE) for extended Small-Cell Lung Cancer...
May 2005: Recenti Progressi in Medicina
F Villani, A Fede Catania, A Laffranchi, L Maffioli, S Viviani, V Bonfante
Mediastinal irradiation combined with chemotherapy in patients with Hodgkin's disease have been associated with cardiopulmonary toxic effects that can last over the years. In this study we monitored pulmonary and cardiac function in 39 patients affected by advanced Hodgkin's disease (stage II B-III and IV) with mediastinal involvement and submitted to an intensive chemotherapy regimen (epirubicin, vincristine, ciclophosphamide, and etoposide) followed by involved field irradiation. Pulmonary function was verified with chest x-ray, spirometric parameters, arterial blood gas analysis, single breath CO transfer factor (DLCO), and its components Dm and Vc...
April 2003: Cancer Investigation
J L Ruiz-Peña, G Izquierdo-Ayuso
AIMS: Technological progress, improvements in the design of clinical trials and in MRI have led to a great variety of therapeutical approaches in dealing with multiple sclerosis (MS), some of which have been successful while others less so, despite promising results from animal models. DEVELOPMENT: In this paper we review the present state of therapy with immunosuppressants in MS and special attention is paid to trials conducted with cladribine, linomide, sulfasalazine, ciclophosphamide, mitoxantrone, cyclosporine A and azatioprine...
August 16, 2002: Revista de Neurologia
A A Jiménez Cordero, O I Varela de la Torre, E Cisneros Olivas
We studied 118 patients with primary ovarian cancer at the Civil Hospital of Guadalajara over a ten-years period; to evaluate incidence, risk factors, clinical aspects, pathology and treatment. Twenty per cent of the patients were classified as stage I, 14 cases (11.8%) stage II, 37 (31%) were stage III and 43 (36%), stage IV. First-stage disease was confirmed by laparotomy; average age was fifty years old, commonly found in patients with invasive carcinoma. Seventy-seven patients received postoperative chemotherapy with cisplatin plus adriamycin and ciclophosphamide or vincrystin, and twelve radiotherapy...
October 1994: Ginecología y Obstetricia de México
B Martinez Martinez, S Juárez Alonso, J Alba Losada, M González Barón, A Ordóñez Gallego
A pregnant woman in the 29th, week of gestation was admitted to the hospital with mediastinal pressure symptoms. A tentative diagnosis of lymphoma was made and the patient was given chemotherapy (vincristine, ciclophosphamide and adriamycin) plus radiotherapy, but no objective response was obtained. During the postoperative period (cesarean section) the patient developed clinical symptoms of muscular paralysis of unknown etiopathogenesis. Biopsy of a cervical lymph node showed histological pattern of tumor of the APUD system (chemodectoma)...
September 25, 1980: Medicina Clínica
A Tres Sánchez, M J Sáez Martínez, J J Mayordomo Cámara, G Guillén Lloveria, A Sáenz Cusi
56 female patients with breast carcinoma and treated with polychemotherapy: adriamycin, vindesine, ciclophosphamide and 5-fluorouracil were studied, divided in three groups with different antiemetic schedule: group A 40 mg/iv of metoclopramide; group B 40 mg iv of metoclopramide and 125 mg/iv of methylprednisolone before beginning chemotherapy; and group C 2 mg/oral of lorazepam, 125 mg/iv methyl-prednisolone and 1 mg/kg/oral of metoclopramide previously to begin chemotherapy; at two and four hours of the first dose, metoclopramide was repeated the same doses (really) three doses each two hours...
May 1990: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
O Jovanović, M Popović-Rolović, M Sindjić, M Kostić, D Kruscić, A Peco-Antić
Clinical and hystological features of IgA nephropathy were evaluated in 17 children (age range 6 to 14 years). Hematuria was present in all patients (macroscopic hematuria in 10 patients, microscopic hematuria in 7). Mild to moderate proteinuria was present in 10, nephrotic syndrome in two cases. The majority of renal biopsy showed normal picture of mild mesangial proliferation, with crescents in only one patient. Transient impairment of renal function developed in two patients. One of patients progressed to chronic renal failure...
November 1992: Srpski Arhiv za Celokupno Lekarstvo
G Pipino, R Germiniani, F Lavorato, A Tajana
The results obtained in 26 patients suffering from metastatic cancer of the breast no longer sensitive to hormone treatment are reported. The patients were treated with ciclophosphamide (CTX) (500 mg i.v.) once a week and triethylenethiophosphamide (20-30 mg i.m.) (TSPA) every 4 weeks associated with cyclophosphamide as follows: CTX--CTX--CTX--CTX+TSPA. 9 objective regressions (34.6%) were observed. Those with objective regression lived 28 months on average (SD 23.45) and those without lived on average 11.41 months (SD 9...
March 17, 1977: Minerva Medica
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