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https://www.readbyqxmd.com/read/29656918/proximity-to-liquor-stores-and-adolescent-alcohol-intake-a-prospective-study
#1
Georgina S A Trapp, Matthew Knuiman, Paula Hooper, Sarah Foster
INTRODUCTION: Cross-sectional studies have reported associations between liquor store availability and alcohol use among adolescents, but few prospective studies have confirmed this association. The aim of this study was to examine whether proximity to liquor stores at age 14 years was associated with alcohol intake at ages 14, 17, and 20 years. METHODS: Participants of the Western Australian Pregnancy Cohort (Raine) Study (n=999) self-reported alcohol intake at age 14 years (early adolescence, 2003-2005); age 17 years (middle adolescence, 2006-2008); and age 20 years (late adolescence, 2009-2011)...
April 12, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29655607/stressful-events-as-teaching-signals-for-the-brain
#2
Sabrina Trapp, John P O'Doherty, Lars Schwabe
Stressful events are better remembered than mundane events. We explain this advantage by reconceptualizing stress in terms of cumulative prediction errors (PEs) that promote rapid learning of events. This proposal integrates the effects of stress on perception and memory, and provides exciting new perspectives for research on stress and cognition.
April 11, 2018: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29652828/can-a-simple-dietary-index-derived-from-a-sub-set-of-questionnaire-items-assess-diet-quality-in-a-sample-of-australian-adults
#3
Alexia Bivoltsis, Georgina S A Trapp, Matthew Knuiman, Paula Hooper, Gina L Ambrosini
Large, longitudinal surveys often lack consistent dietary data, limiting the use of existing tools and methods that are available to measure diet quality. This study describes a method that was used to develop a simple index for ranking individuals according to their diet quality in a longitudinal study. The RESIDential Environments (RESIDE) project (2004-2011) collected dietary data in varying detail, across four time points. The most detailed dietary data were collected using a 24-item questionnaire at the final time point ( n = 555; age ≥ 25 years)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29625383/architecture-and-activation-of-phosphatidylinositol-3-kinase-related-kinases
#4
REVIEW
Stefan Imseng, Christopher Hs Aylett, Timm Maier
The phosphatidylinositol 3-kinase related protein kinases (PIKKs) are key to the regulation of a variety of eukaryotic cellular processes including DNA repair and growth regulation. While these massive proteins had long resisted structural analysis, recent advances in electron cryo-microscopy have now facilitated structural analysis of the major examples of PIKKs, including mTOR, DNA-PK, ATM, ATR and TRAPP/Tra1. In these PIKKs, the carboxy-terminal kinase domains and their proximal regions are structurally conserved...
April 3, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29587836/atrophy-of-primary-lymphoid-organs-induced-by-marek-s-disease-virus-during-early-infection-is-associated-with-increased-apoptosis-inhibition-of-cell-proliferation-and-a-severe-b-lymphopenia
#5
Camille Berthault, Thibaut Larcher, Sonja Härtle, Jean-François Vautherot, Laetitia Trapp-Fragnet, Caroline Denesvre
Marek's disease is a multi-faceted highly contagious disease affecting chickens caused by the Marek's disease alphaherpesvirus (MDV). MDV early infection induces a transient immunosuppression, which is associated with thymus and bursa of Fabricius atrophy. Little is known about the cellular processes involved in primary lymphoid organ atrophy. Here, by in situ TUNEL assay, we demonstrate that MDV infection results in a high level of apoptosis in the thymus and bursa of Fabricius, which is concomitant to the MDV lytic cycle...
March 27, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29587792/major-contribution-of-the-rna-binding-domain-of-ns1-in-the-pathogenicity-and-replication-potential-of-an-avian-h7n1-influenza-virus-in-chickens
#6
Sascha Trapp, Denis Soubieux, Alexandra Lidove, Evelyne Esnault, Adrien Lion, Vanaique Guillory, Alan Wacquiez, Emmanuel Kut, Pascale Quéré, Thibaut Larcher, Mireille Ledevin, Virginie Nadan, Christelle Camus-Bouclainville, Daniel Marc
BACKGROUND: Non-structural protein NS1 of influenza A viruses harbours several determinants of pathogenicity and host-range. However it is still unclear to what extent each of its two structured domains (i.e. RNA-binding domain, RBD, and effector domain, ED) contribute to its various activities. METHODS: To evaluate the respective contributions of the two domains, we genetically engineered two variants of an H7N1 low pathogenicity avian influenza virus harbouring amino-acid substitutions that impair the functionality of either domain...
March 27, 2018: Virology Journal
https://www.readbyqxmd.com/read/29570537/myocellular-responses-to-concurrent-flywheel-training-during-70-days-of-bed-rest
#7
Kevin A Murach, Kiril Minchev, Greg J Grosicki, Kaleen Lavin, Ryan K Perkins, Jeffrey W Ryder, Jessica Scott, Lori Ploutz-Snyder, Todd A Trappe, Scott Trappe
PURPOSE: This investigation evaluated myocellular responses to an integrated resistance and aerobic training program (SPRINT) during 70 days of bed rest. METHODS: Training was six days per week on a small-footprint gravity-independent flywheel resistance and aerobic device (FLY); three days of maximal flywheel supine quadriceps and calf exercises with continuous rowing separated by 4-6 hours, and three days of interval rowing. Vastus lateralis (VL) and soleus (SOL) muscle biopsies were obtained from eight healthy males (age=28±4 y, BMI=25±3 kg•m, VO2max=42±6 ml•kg•min) before and after 6° head-intrdown tilt bed rest...
March 22, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29548758/insulin-like-receptors-and-carbohydrate-metabolism-in-gills-of-the-euryhaline-crab-neohelice-granulata-effects-of-osmotic-stress
#8
Márcia Trapp, Sandra Costa Valle, Alan Gomes Pöppl, Ana Lúcia Fernandes Chittó, Luiz Carlos Kucharski, Roselis Silveira Martins Da Silva
The present study determined the effect of osmotic stress on the insulin-like receptor binding characteristics and on glucose metabolism in the anterior (AG) and posterior (PG) gills of the crab Neohelice granulata. Bovine insulin increased the capacity of the PG cell membrane to phosphorylate exogenous substrate poly (Glu:Tyr 4:1) and the glucose uptake in the control crab group. The crabs were submitted to three periods of hyperosmotic (HR) and hyposmotic (HO) stress, for 24, 72 and 144 h, to investigate the insulin-like receptor phosphorylation capacity of gills...
March 13, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29512427/the-role-of-the-thalamus-and-hippocampus-in-episodic-memory-performance-in-patients-with-multiple-sclerosis
#9
Katherine A Koenig, Stephen M Rao, Mark J Lowe, Jian Lin, Ken E Sakaie, Lael Stone, Robert A Bermel, Bruce D Trapp, Micheal D Phillips
BACKGROUND: Episodic memory loss is one of the most common cognitive symptoms in patients with multiple sclerosis (MS), but the pathophysiology of this symptom remains unclear. Both the hippocampus and thalamus have been implicated in episodic memory and show regional atrophy in patients with MS. OBJECTIVE: In this work, we used functional magnetic resonance imaging (fMRI) during a verbal episodic memory task, lesion load, and volumetric measures of the hippocampus and thalamus to assess the relative contributions to verbal and visual-spatial episodic memory...
March 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29490302/endocrine-treatment-with-2-years-of-tamoxifen-versus-2-years-of-exemestane-in-postmenopausal-patients-with-high-risk-early-breast-cancer-and-persisting-circulating-tumor-cells-first-results-of-the-success-c-endocrine-treatment-sub-study
#10
Fabienne Schochter, Brigitte Rack, Marie Tzschaschel, Arkadius Polasik, Ulrich Andergassen, Elisabeth Trapp, Marianna Alunni-Fabbroni, Andreas Schneeweiss, Volkmar Müller, Klaus Pantel, Jörg Gade, Ralf Lorenz, Mahdi Rezai, Hans Tesch, Ulrike Soeling, Tanja Fehm, Sven Mahner, Christian Schindlbeck, Werner Lichtenegger, Matthias W Beckmann, Peter A Fasching, Wolfgang Janni, Thomas W P Friedl
BACKGROUND: Optimal choice and sequence of endocrine treatment following adjuvant chemotherapy in postmenopausal early breast cancer patients are still under discussion and treatment stratification factors are missing. PATIENTS AND METHODS: Postmenopausal women with HER2-negative, hormone receptor-positive tumors and persisting circulating tumor cells (CTCs; assessed using the FDA-approved CellSearch® System, Janssen Diagnostics, LLC) after chemotherapy were randomized to 2 years of tamoxifen followed by 3 years of exemestane (tamoxifen-exemestane group, n = 54) or 5 years of exemestane (exemestane-only group, n = 54)...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29464295/-evolution-and-principles-of-intramedullary-locked-nailing
#11
C Hierholzer, J Friederichs, P Augat, A Woltmann, O Trapp, V Bühren, C von Rüden
Key factors for successful osteosynthetic fracture stabilization are anatomical fracture reduction, restoration of axis and torsion alignment as well as tissue-preserving operative techniques. In long bone fractures, the use of intramedullary long bridging nailing offers ideal conditions for bone healing, as axial and rotational stability is provided by canal-filling nails and locking screws. In addition, the tissue in the fracture region is protected as the intramedullary nail insertion is distant from the fracture...
February 20, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29459726/the-systemin-receptor-syr1-enhances-resistance-of-tomato-against-herbivorous-insects
#12
Lei Wang, Elias Einig, Marilia Almeida-Trapp, Markus Albert, Judith Fliegmann, Axel Mithöfer, Hubert Kalbacher, Georg Felix
The discovery in tomato of systemin, the first plant peptide hormone1,2 , was a fundamental change for the concept of plant hormones. Numerous other peptides have since been shown to play regulatory roles in many aspects of the plant life, including growth, development, fertilization and interactions with symbiotic organisms3-6 . Systemin, an 18 amino acid peptide derived from a larger precursor protein 7 , was proposed to act as the spreading signal that triggers systemic defence responses observed in plants after wounding or attack by herbivores1,7,8 ...
March 2018: Nature Plants
https://www.readbyqxmd.com/read/29456020/advanced-sirna-designs-further-improve-in-vivo-performance-of-galnac-sirna-conjugates
#13
Donald J Foster, Christopher R Brown, Sarfraz Shaikh, Casey Trapp, Mark K Schlegel, Kun Qian, Alfica Sehgal, Kallanthottathil G Rajeev, Vasant Jadhav, Muthiah Manoharan, Satya Kuchimanchi, Martin A Maier, Stuart Milstein
Significant progress has been made in the advancement of RNAi therapeutics by combining a synthetic triantennary N-acetylgalactosamine ligand targeting the asialoglycoprotein receptor with chemically modified small interfering RNA (siRNA) designs, including the recently described Enhanced Stabilization Chemistry. This strategy has demonstrated robust RNAi-mediated gene silencing in liver after subcutaneous administration across species, including human. Here we demonstrate that substantial efficacy improvements can be achieved through further refinement of siRNA chemistry, optimizing the positioning of 2'-deoxy-2'-fluoro and 2'-O-methyl ribosugar modifications across both strands of the double-stranded siRNA duplex to enhance stability without compromising intrinsic RNAi activity...
January 4, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29450560/-ecg-results-tips-and-tricks-for-the-correct-diagnosis-bradycardia-and-tachycardia-rhythm-disorders
#14
H-J Trappe
The 12-lead surface electrocardiogram (ECG) is of great importance for the diagnostics of cardiac arrhythmias. For the correct and systematic analysis it has a sensitivity and specificity for the correct diagnosis of supraventricular tachycardia or ventricular tachycardia of more than 95%. Nevertheless, the assessment of cardiac rhythm disorders is difficult for many physicians. In this way errors can occur, frequently due to a non-systematic analysis of the ECG; therefore, the aim of this article is to present the techniques and the necessary knowledge for assessment of the most frequent bradycardiac and tachycardiac heart rhythm disorders...
February 15, 2018: Herz
https://www.readbyqxmd.com/read/29431744/a-histone-deacetylase-3-dependent-pathway-delimits-peripheral-myelin-growth-and-functional-regeneration
#15
Xuelian He, Liguo Zhang, Luis F Queme, Xuezhao Liu, Andrew Lu, Ronald R Waclaw, Xinran Dong, Wenhao Zhou, Grahame Kidd, Sung-Ok Yoon, Andres Buonanno, Joshua B Rubin, Mei Xin, Klaus-Armin Nave, Bruce D Trapp, Michael P Jankowski, Q Richard Lu
Deficits in Schwann cell-mediated remyelination impair functional restoration after nerve damage, contributing to peripheral neuropathies. The mechanisms mediating block of remyelination remain elusive. Here, through small-molecule screening focusing on epigenetic modulators, we identified histone deacetylase 3 (HDAC3; a histone-modifying enzyme) as a potent inhibitor of peripheral myelinogenesis. Inhibition of HDAC3 enhanced myelin growth and regeneration and improved functional recovery after peripheral nerve injury in mice...
February 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29423572/integrating-predictive-frameworks-and-cognitive-models-of-face-perception
#16
REVIEW
Sabrina Trapp, Stefan R Schweinberger, William G Hayward, Gyula Kovács
The idea of a "predictive brain"-that is, the interpretation of internal and external information based on prior expectations-has been elaborated intensely over the past decade. Several domains in cognitive neuroscience have embraced this idea, including studies in perception, motor control, language, and affective, social, and clinical neuroscience. Despite the various studies that have used face stimuli to address questions related to predictive processing, there has been surprisingly little connection between this work and established cognitive models of face recognition...
February 8, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29410816/parenting-behaviour-is-highly-heritable-in-male-stickleback
#17
Alison M Bell, Rebecca Trapp, Jason Keagy
Parental care is critical for fitness, yet little is known about its genetic basis. Here, we estimate the heritability of parenting behaviour in a species famous for its diversity and its behavioural repertoire: three-spined stickleback (Gasterosteus aculeatus). Male three-spined stickleback are the sole providers of parental care that is necessary for offspring survival; therefore, this system offers the opportunity to study the inheritance of parental behaviour when selection is primarily acting on males...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29409452/whole-blood-micrornas-as-potential-biomarkers-in-post-operative-early-breast-cancer-patients
#18
Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K Trapp, Marie Tzschaschel, Sven Mahner, Peter A Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W P Friedl, Wolfgang Janni, Brigitte Rack
BACKGROUND: microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (CTCs) and clinical outcome in post-operative early breast cancer patients (EBC) to assess the utility of miRNAs as prognostic markers in this setting. METHOD: A total of 48 post-operative patients, recruited in frame of the SUCCESS A trial, were included in this retrospective study and tested with a panel of 8 miRNAs (miR-10b, -19a, - 21, - 22, -20a, - 127, - 155, -200b)...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29391579/a-missense-mutation-in-trappc6a-leads-to-build-up-of-the-protein-in-patients-with-a-neurodevelopmental-syndrome-and-dysmorphic-features
#19
Hussein Sheikh Mohamoud, Saleem Ahmed, Musharraf Jelani, Nuha Alrayes, Kay Childs, Nirmal Vadgama, Mona Mohammad Almramhi, Jumana Yousuf Al-Aama, Steve Goodbourn, Jamal Nasir
Childhood onset clinical syndromes involving intellectual disability and dysmorphic features, such as polydactyly, suggest common developmental pathways link seemingly unrelated phenotypes. We identified a consanguineous family of Saudi origin with varying complex features including intellectual disability, speech delay, facial dysmorphism and polydactyly. Combining, microarray based comparative genomic hybridisation (CGH) to identify regions of homozygosity, with exome sequencing, led to the identification of homozygous mutations in five candidate genes (RSPH6A, ANKK1, AMOTL1, ALKBH8, TRAPPC6A), all of which appear to be pathogenic as predicted by Proven, SIFT and PolyPhen2 and segregate perfectly with the disease phenotype...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29374288/-quality-of-life-and-posttraumatic-stress-disorder-after-out-of-hospital-cardiac-arrest
#20
I von Auenmüller, M Christ, M Brand, W Dierschke, H-J Trappe
BACKGROUND: Survival rate after out-of-hospital cardiac arrest (OHCA) is increasing. However, there is a lack of data concerning long-term quality of life of affected patients. OBJECTIVES: This study aims to investigate the psychological effects of out-of-hospital cardiopulmonary resuscitation. METHODS: All patients who were admitted to our hospital after OHCA between 01 January 2008 and 30 June 2015 and could be discharged in good neurological condition were asked to fill out the Impact of Event Scale-Revised (IES-R) and 36-Item Short Form Health Survey (SF-36)...
January 26, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
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