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Sieghard Albert, Ziqiu Chen, Karen Keppler, Philippe Lerch, Martin Quack, Volker Schurig, Oliver Trapp
The rotational spectrum of monodeutero-oxirane was analysed as measured using the Zurich Gigahertz (GHz) spectrometer and our highest resolution Fourier Transform Infrared (FTIR) spectrometer system coupled to synchrotron radiation at the Swiss Light Source (SLS). 112 distinct line frequencies have been newly assigned in the GHz range (extended to 120 GHz, compared to previous work extending to only 59 GHz) including rotational states up to J = 23. We have furthermore assigned 398 lines in the far infrared or Terahertz range (0...
November 16, 2018: Physical Chemistry Chemical Physics: PCCP
Cornelius Gropp, Tamara Husch, Nils Trapp, Markus Reiher, François Diederich
Enantiopure (P)4 - and (M)4 -alleno-acetylenic cage (AAC) receptors form circular fourfold hydrogen-bonding networks in their closed cage conformation. Theoretical studies reveal a preferential clockwise (cw) orientation of the H-bonding array for (P)4 -configured and counterclockwise (ccw) for (M)4 -configured receptors (ΔEcw-ccw =-2.6 to -3.1 kcal mol-1 ). Solution and solid-state studies show how the H-bonding network of the receptor is expanded upon encapsulation of alcohol-containing guests. Topologies reminiscent of those found in isolated water clusters are observed: circular fourfold & docking, pentagonal, linear fivefold, and hexagonal boat-shaped...
November 12, 2018: Angewandte Chemie
Shan H Siddiqi, Nicholas T Trapp, Carl D Hacker, Timothy O Laumann, Sridhar Kandala, Xin Hong, Ludwig Trillo, Pashtun-Poh Shahim, Eric Leuthardt, Alexandre R Carter, David Brody
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has demonstrated antidepressant efficacy, but has limited evidence in depression associated with traumatic brain injury (TBI). Here, we investigate the use of rTMS targeted with individualized resting-state network mapping (RSNM) of dorsal attention network (DAN) and default mode network (DMN) in subjects with treatment-resistant depression associated with TBI. METHODS: 14 Subjects with treatment-resistant depression and prior concussive or moderate TBI received resting-state fMRI scans with individual-level RSNM...
November 1, 2018: Journal of Neurotrauma
Marilia Almeida-Trapp, Axel Mithöfer
There is strong evidence that phytohormones such as abscisic acid, auxin, salicylic acid, and jasmonates might play a role in defense of the host plants during phytoplasma infections. However, these compounds are usually present at low concentration in complex matrixes, requiring a sensitive and selective method to analyze and quantify them. Here, we present a HPLC-MS/MS method to quantify phytohormones in different infected and noninfected plant tissues.
2019: Methods in Molecular Biology
Claire Elizabeth Pulker, Georgina S A Trapp, Frances Foulkes-Taylor, Jane Anne Scott, Christina Mary Pollard
BACKGROUND: While public health experts have identified food environments as a driver of poor diet, they also hold great potential to reduce obesity, non-communicable diseases, and their inequalities. Supermarkets are the dominant retail food environment in many developed countries including Australia. The contribution of supermarket own brands to the healthfulness of retail food environments has not yet been explored. The aim of this protocol is to describe the methods developed to examine the availability, nutritional quality, price, placement and promotion of supermarket own brand foods within Australian supermarkets...
October 25, 2018: Nutrition Journal
Tiela Trapp Grassotti, Dejoara de Angelis Zvoboda, Letícia da Fontoura Xavier Costa, Alberto Jorge Gomes de Araújo, Rebeca Inhoque Pereira, Renata Oliveira Soares, Paulo Guilherme Carniel Wagner, Jeverson Frazzon, Ana Paula Guedes Frazzon
The environment, human, and animals play an important role in the spread of antibiotic-resistant bacteria. Enterococci are members of the gastrointestinal tracts of humans and animals and represent important reservoirs of antibiotic resistance genes. Until today, few studies have examined antibiotic susceptibility in enterococci isolated from primates. Therefore, the present study investigated species distribution, antibiotic susceptibility, and resistance genes in enterococci isolated from wild and captive black capuchins monkeys ( Sapajus nigritus ) in Rio Grande do Sul, South Brazil...
2018: Frontiers in Microbiology
M Christ, K I von Auenmüller, T von den Benken, S Fessaras, W Dierschke, H-J Trappe
INTRODUCTION: Only a little is known about the frequency of use of supraglottic airway devices (SADs) and intraosseous (IO) access in patients who have had out-of-hospital cardiac arrest (OHCA). MATERIALS AND METHODS: We analyzed data from all patients who had had OHCA admitted to our hospital between 1 January 2008 and 31 December 2017. RESULTS: A total of 135 (33.8%) patients who had had OHCA were admitted with a SAD, 223 (55.8%) with an endotracheal tube, 3 (0...
October 23, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Carolina Piña Páez, Gregory M Bonito, Gonzalo Guevara-Guerrero, Michael A Castellano, Roberto Garibay-Orijel, James M Trappe, Rafael Peña Rámirez
The genus Tuber is a lineage of diverse ectomycorrhizal, hypogeous, sequestrate ascomycete fungi that are native to temperate forests in the Northern Hemisphere. Recently, many new species of Tuber have been described in North America and Asia, based on morphological characteristics and molecular data. Here we describe and illustrate a new species, Tuberincognitum , based upon phylogenetic analysis and morphological description. We also present a new record for Tuberanniae in México. These two Tuber species are distributed in the Transmexican Volcanic Belt in the states of México, Michoacán, Guanajuato, Querétaro and Tlaxcala at altitudes between 2,000 and 3,200 meters...
2018: MycoKeys
Raissa L Davis, Geunho Choi, Thijs Kuiken, Pascale Quéré, Sascha Trapp, Kirsty R Short, Mathilde Richard
BACKGROUND: Endothelial cells play a major role in highly pathogenic avian influenza (HPAI) virus pathogenesis in gallinaceous poultry species (e.g. chicken, turkey and quail). Upon infection of gallinaceous poultry with HPAI viruses, endothelial cells throughout the body become rapidly infected, leading to systemic dissemination of the virus, disseminated intravascular coagulation, oedema and haemorrhaging. In contrast, the pathogenesis of HPAI viruses in most wild bird species (e.g...
October 19, 2018: BMC Microbiology
Anna K Trapp, Carolin Wienrich
Users of mobile touch devices are often confronted with a great number of apps, challenging an efficient access to single applications. Especially when looking for infrequently used apps, users have to perform a visual search. We address this problem in two studies by applying knowledge about visual search efficiency to app icons on mobile touch devices. We aimed to transfer findings of similarity grouping for complex stimuli to a more applied setting and to investigate the effect of search efficiency on user experience...
October 17, 2018: Cognitive Research: Principles and Implications
Stephen K Trapp, Melissa M Ertl, Susana Gonzalez-Arredondo, Yaneth Rodriguez-Agudelo, Juan Carlos Arango-Lasprilla
ABSTRACTBackground:Informal caregivers of individuals with Parkinson's disease face a range of responsibilities that increase as the disease progresses. As a result of these stressors, caregivers are vulnerable to decreased health-related quality of life (HRQOL). Guided by the stress process model of caregiving, the present study examined the relations between family cohesion, perceived burden, and mental and physical HRQOL among Parkinson's disease caregivers in Mexico. It was hypothesized that perceived burden would mediate the relations of family cohesion and mental and physical HRQOL...
October 15, 2018: International Psychogeriatrics
Elisabeth Trapp, Wolfgang Janni, Christian Schindlbeck, Julia Jückstock, Ulrich Andergassen, Amelie de Gregorio, Marianna Alunni-Fabbroni, Marie Tzschaschel, Arkadius Polasik, Julian G Koch, Thomas W P Friedl, Peter A Fasching, Lothar Haeberle, Tanja Fehm, Andreas Schneeweiss, Matthias W Beckmann, Klaus Pantel, Volkmar Mueller, Brigitte Rack, Christoph Scholz
Background: The prognostic relevance of circulating tumor cells (CTCs) at the time of primary diagnosis has been well established. However, little information is available regarding their prognostic relevance to follow-up care. Methods: The multicenter, open-label, phase III SUCCESS A trial compared two adjuvant chemotherapy regimens followed by 2 vs 5 years of zoledronate for early-stage, high-risk breast cancer patients. The presence of CTCs was assessed before and 2 years after chemotherapy using the FDA-approved CellSearch System...
October 11, 2018: Journal of the National Cancer Institute
Kristy Lee, Kate Krempely, Maegan E Roberts, Michael J Anderson, Fatima Carneiro, Elizabeth Chao, Katherine Dixon, Joana Figueiredo, Rajarshi Ghosh, David Huntsman, Pardeep Kaurah, Chimene Kesserwan, Tyler Landrith, Shuwei Li, Arjen R Mensenkamp, Carla Oliveira, Carolina Pardo, Tina Pesaran, Matthew Richardson, Thomas P Slavin, Amanda B Spurdle, Mackenzie Trapp, Leora Witkowski, Charles S Yi, Liying Zhang, Sharon E Plon, Kasmintan A Schrader, Rachid Karam
The variant curation guidelines published in 2015 by the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) provided the genetics community with a framework to assess variant pathogenicity; however, these rules are not gene specific. Germline pathogenic variants in the CDH1 gene cause hereditary diffuse gastric cancer and lobular breast cancer, a clinically challenging cancer predisposition syndrome that often requires a multidisciplinary team of experts to be properly managed...
November 2018: Human Mutation
Jiayue Cai, Aiping Liu, Taomian Mi, Saurabh Garg, Wade Trappe, Martin J McKeown, Z Jane Wang
Graph theoretical analysis is a powerful tool for quantitatively understanding the topological properties of complex networks, such as system-level descriptions of brain connectivity. In conventional functional connectivity analysis, brain connectivity is assumed to be temporally stationary, while increasing evidence suggests that functional connectivity exhibits temporal variations during dynamic brain activity. Although a number of methods have been developed to estimate time-dependent brain connectivity, there is a paucity of studies examining the utility of brain dynamics for assessing brain disease states...
October 11, 2018: IEEE Journal of Biomedical and Health Informatics
Claire Elizabeth Pulker, Georgina S A Trapp, Jane Anne Scott, Christina Mary Pollard
Two voluntary front-of-pack nutrition labels (FOPNL) are present in Australia: the government-led Health Star Ratings (HSR) and food industry-led Daily Intake Guide (DIG). Australia's two largest supermarkets are key supporters of HSR, pledging uptake on all supermarket own brand foods (SOBF). This study aimed to examine prevalence of FOPNL on SOBF, and alignment with patterns of nutritional quality. Photographic audits of all SOBF present in three large supermarkets were conducted in Perth, Western Australia, in 2017...
October 9, 2018: Nutrients
Florian Füssl, Anne Trappe, Ken Cook, Kai Scheffler, Oliver Fitzgerald, Jonathan Bones
Charge variant analysis is a widely used tool to monitor changes in product quality during the manufacturing process of monoclonal antibodies (mAbs). Although it is a powerful technique for revealing mAb heterogeneity, an unexpected outcome, for example the appearance of previously undetected isoforms, requires further, time-consuming analysis. The process of identifying these unknowns can also result in unwanted changes to the molecule that are not attributable to the manufacturing process. To overcome this, we recently reported a method combining highly selective cation exchange chromatography-based charge variant analysis with on-line mass spectrometric (MS) detection...
October 8, 2018: MAbs
Nicholas T Trapp, Willa Xiong, Charles R Conway
Depression is one of the most disabling conditions in the world. In many cases patients continue to suffer with depressive disorders despite a series of adequate trials of medication and psychotherapy. Neuromodulation treatments offer a qualitatively different modality of treatment that can frequently prove efficacious in these treatment-refractory patients. The field of neuromodulation focuses on the use of electrical/electromagnetic energy, both invasively and noninvasively, to interface with and ultimately alter activity within the human brain for therapeutic purposes...
October 8, 2018: Handbook of Experimental Pharmacology
Alexander F Siegle, Sebastian Pallmann, Oliver Trapp
Hadamard encoding, utilizing pseudo-random injection sequences with n-bit (2n -1) elements, is applied in analytical sciences to enhance the signal-to-noise ratio (S/N) of weak analyte signals. We have developed a software approach that allows using Hadamard encoding on standard HPLC systems. This strategy is only limited by the number of instructions that can be transmitted to the autosampler and its performance degrades if an accumulation of chromatographic irregularities occurs while applying long modulation sequences...
November 9, 2018: Journal of Chromatography. A
Marie K Holt, James E Richards, Daniel R Cook, Daniel I Brierley, Diana L Williams, Frank Reimann, Fiona M Gribble, Stefan Trapp
Centrally administered glucagon-like peptide-1 (GLP-1) supresses food intake. Here we demonstrate that GLP-1-producing (PPG) neurons in the nucleus tractus solitarii (NTS) are the predominant source of endogenous GLP-1 within the brain. Selective ablation of NTS PPG neurons by viral expression of diphtheria toxin subunit A (DTA) substantially reduced active GLP-1 concentrations in brain and spinal cord. Contrary to expectations, this loss of central GLP-1 had no significant effect on ad libitum feeding of mice, affecting neither daily chow intake nor body weight or glucose tolerance...
October 2, 2018: Diabetes
Stephen Trapp, Justin MacKenzie, Susana Gonzalez-Arredondo, Yaneth Rodriguez-Agudelo, Juan Carlos Arango-Lasprilla
Objective This study examined the mediating role of caregiver distress on family factors and caregiver life satisfaction among an understudied population of Parkinson's disease caregiver in Mexico. Methods A cross-sectional design was used to examine psychosocial factors pertinent to caregiver of individuals with Parkinson's disease ( n = 95). Guided by a caregiver stress process model, relations among family factors (e.g., cohesion, flexibility, quality of functioning), gender, distress, and satisfaction with life among caregiver were examined...
October 2, 2018: International Journal of Psychiatry in Medicine
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