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https://www.readbyqxmd.com/read/29464295/-evolution-and-principles-of-intramedullary-locked-nailing
#1
C Hierholzer, J Friederichs, P Augat, A Woltmann, O Trapp, V Bühren, C von Rüden
Key factors for successful osteosynthetic fracture stabilization are anatomical fracture reduction, restoration of axis and torsion alignment as well as tissue-preserving operative techniques. In long bone fractures, the use of intramedullary long bridging nailing offers ideal conditions for bone healing, as axial and rotational stability is provided by canal-filling nails and locking screws. In addition, the tissue in the fracture region is protected as the intramedullary nail insertion is distant from the fracture...
February 20, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29459726/the-systemin-receptor-syr1-enhances-resistance-of-tomato-against-herbivorous-insects
#2
Lei Wang, Elias Einig, Marilia Almeida-Trapp, Markus Albert, Judith Fliegmann, Axel Mithöfer, Hubert Kalbacher, Georg Felix
The discovery in tomato of systemin, the first plant peptide hormone1,2 , was a fundamental change for the concept of plant hormones. Numerous other peptides have since been shown to play regulatory roles in many aspects of the plant life, including growth, development, fertilization and interactions with symbiotic organisms3-6 . Systemin, an 18 amino acid peptide derived from a larger precursor protein7 , was proposed to act as the spreading signal that triggers systemic defence responses observed in plants after wounding or attack by herbivores1,7,8 ...
February 19, 2018: Nature Plants
https://www.readbyqxmd.com/read/29456020/advanced-sirna-designs-further-improve-in-vivo-performance-of-galnac-sirna-conjugates
#3
Donald J Foster, Christopher R Brown, Sarfraz Shaikh, Casey Trapp, Mark K Schlegel, Kun Qian, Alfica Sehgal, Kallanthottathil G Rajeev, Vasant Jadhav, Muthiah Manoharan, Satya Kuchimanchi, Martin A Maier, Stuart Milstein
Significant progress has been made in the advancement of RNAi therapeutics by combining a synthetic triantennary N-acetylgalactosamine ligand targeting the asialoglycoprotein receptor with chemically modified small interfering RNA (siRNA) designs, including the recently described Enhanced Stabilization Chemistry. This strategy has demonstrated robust RNAi-mediated gene silencing in liver after subcutaneous administration across species, including human. Here we demonstrate that substantial efficacy improvements can be achieved through further refinement of siRNA chemistry, optimizing the positioning of 2'-deoxy-2'-fluoro and 2'-O-methyl ribosugar modifications across both strands of the double-stranded siRNA duplex to enhance stability without compromising intrinsic RNAi activity...
January 4, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29450560/-ecg-results-tips-and-tricks-for-the-correct-diagnosis-bradycardia-and-tachycardia-rhythm-disorders
#4
H-J Trappe
The 12-lead surface electrocardiogram (ECG) is of great importance for the diagnostics of cardiac arrhythmias. For the correct and systematic analysis it has a sensitivity and specificity for the correct diagnosis of supraventricular tachycardia or ventricular tachycardia of more than 95%. Nevertheless, the assessment of cardiac rhythm disorders is difficult for many physicians. In this way errors can occur, frequently due to a non-systematic analysis of the ECG; therefore, the aim of this article is to present the techniques and the necessary knowledge for assessment of the most frequent bradycardiac and tachycardiac heart rhythm disorders...
February 15, 2018: Herz
https://www.readbyqxmd.com/read/29431744/a-histone-deacetylase-3-dependent-pathway-delimits-peripheral-myelin-growth-and-functional-regeneration
#5
Xuelian He, Liguo Zhang, Luis F Queme, Xuezhao Liu, Andrew Lu, Ronald R Waclaw, Xinran Dong, Wenhao Zhou, Grahame Kidd, Sung-Ok Yoon, Andres Buonanno, Joshua B Rubin, Mei Xin, Klaus-Armin Nave, Bruce D Trapp, Michael P Jankowski, Q Richard Lu
Deficits in Schwann cell-mediated remyelination impair functional restoration after nerve damage, contributing to peripheral neuropathies. The mechanisms mediating block of remyelination remain elusive. Here, through small-molecule screening focusing on epigenetic modulators, we identified histone deacetylase 3 (HDAC3; a histone-modifying enzyme) as a potent inhibitor of peripheral myelinogenesis. Inhibition of HDAC3 enhanced myelin growth and regeneration and improved functional recovery after peripheral nerve injury in mice...
February 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29423572/integrating-predictive-frameworks-and-cognitive-models-of-face-perception
#6
REVIEW
Sabrina Trapp, Stefan R Schweinberger, William G Hayward, Gyula Kovács
The idea of a "predictive brain"-that is, the interpretation of internal and external information based on prior expectations-has been elaborated intensely over the past decade. Several domains in cognitive neuroscience have embraced this idea, including studies in perception, motor control, language, and affective, social, and clinical neuroscience. Despite the various studies that have used face stimuli to address questions related to predictive processing, there has been surprisingly little connection between this work and established cognitive models of face recognition...
February 8, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29410816/parenting-behaviour-is-highly-heritable-in-male-stickleback
#7
Alison M Bell, Rebecca Trapp, Jason Keagy
Parental care is critical for fitness, yet little is known about its genetic basis. Here, we estimate the heritability of parenting behaviour in a species famous for its diversity and its behavioural repertoire: three-spined stickleback (Gasterosteus aculeatus). Male three-spined stickleback are the sole providers of parental care that is necessary for offspring survival; therefore, this system offers the opportunity to study the inheritance of parental behaviour when selection is primarily acting on males...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29409452/whole-blood-micrornas-as-potential-biomarkers-in-post-operative-early-breast-cancer-patients
#8
Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K Trapp, Marie Tzschaschel, Sven Mahner, Peter A Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W P Friedl, Wolfgang Janni, Brigitte Rack
BACKGROUND: microRNAs (miRNAs) are considered promising cancer biomarkers, showing high reliability, sensitivity and stability. Our study aimed to identify associations between whole blood miRNA profiles, presence of circulating tumor cells (CTCs) and clinical outcome in post-operative early breast cancer patients (EBC) to assess the utility of miRNAs as prognostic markers in this setting. METHOD: A total of 48 post-operative patients, recruited in frame of the SUCCESS A trial, were included in this retrospective study and tested with a panel of 8 miRNAs (miR-10b, -19a, - 21, - 22, -20a, - 127, - 155, -200b)...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29391579/a-missense-mutation-in-trappc6a-leads-to-build-up-of-the-protein-in-patients-with-a-neurodevelopmental-syndrome-and-dysmorphic-features
#9
Hussein Sheikh Mohamoud, Saleem Ahmed, Musharraf Jelani, Nuha Alrayes, Kay Childs, Nirmal Vadgama, Mona Mohammad Almramhi, Jumana Yousuf Al-Aama, Steve Goodbourn, Jamal Nasir
Childhood onset clinical syndromes involving intellectual disability and dysmorphic features, such as polydactyly, suggest common developmental pathways link seemingly unrelated phenotypes. We identified a consanguineous family of Saudi origin with varying complex features including intellectual disability, speech delay, facial dysmorphism and polydactyly. Combining, microarray based comparative genomic hybridisation (CGH) to identify regions of homozygosity, with exome sequencing, led to the identification of homozygous mutations in five candidate genes (RSPH6A, ANKK1, AMOTL1, ALKBH8, TRAPPC6A), all of which appear to be pathogenic as predicted by Proven, SIFT and PolyPhen2 and segregate perfectly with the disease phenotype...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29374288/-quality-of-life-and-posttraumatic-stress-disorder-after-out-of-hospital-cardiac-arrest
#10
I von Auenmüller, M Christ, M Brand, W Dierschke, H-J Trappe
BACKGROUND: Survival rate after out-of-hospital cardiac arrest (OHCA) is increasing. However, there is a lack of data concerning long-term quality of life of affected patients. OBJECTIVES: This study aims to investigate the psychological effects of out-of-hospital cardiopulmonary resuscitation. METHODS: All patients who were admitted to our hospital after OHCA between 01 January 2008 and 30 June 2015 and could be discharged in good neurological condition were asked to fill out the Impact of Event Scale-Revised (IES-R) and 36-Item Short Form Health Survey (SF-36)...
January 26, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29361242/mr-imaging-based-estimation-of-upper-motor-neuron-density-in-patients-with-amyotrophic-lateral-sclerosis-a-feasibility-study
#11
Jacqueline Chen, Volodymyr Kostenko, Erik P Pioro, Bruce D Trapp
Purpose To determine if magnetic resonance (MR) imaging metrics can estimate primary motor cortex (PMC) motor neuron (MN) density in patients with amyotrophic lateral sclerosis (ALS). Materials and Methods Between 2012 and 2014, in situ brain MR imaging was performed in 11 patients with ALS (age range, 35-81 years; seven women and four men) soon after death (mean, 5.5 hours after death; range, 3.2-9.6 hours). The brain was removed, right PMC (RPMC) was excised, and MN density was quantified. RPMC metrics (thickness, volume, and magnetization transfer ratio) were calculated from MR images...
January 23, 2018: Radiology
https://www.readbyqxmd.com/read/29349853/piezotronic-tuning-of-potential-barriers-in-zno-bicrystals
#12
Peter Keil, Maximilian Trapp, Nikola Novak, Till Frömling, Hans-Joachim Kleebe, Jürgen Rödel
Coupling of magnetic, ferroelectric, or piezoelectric properties with charge transport at oxide interfaces provides the option to revolutionize classical electronics. Here, the modulation of electrostatic potential barriers at tailored ZnO bicrystal interfaces by stress-induced piezoelectric polarization is reported. Specimen design by epitaxial solid-state transformation allows for both optimal polarization vector alignment and tailoring of defect states at a semiconductor-semiconductor interface. Both quantities are probed by transmission electron microscopy...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29344724/when-the-rhythm-disappears-and-the-mind-keeps-dancing-sustained-effects-of-attentional-entrainment
#13
Sabrina Trapp, Ondrej Havlicek, Annett Schirmer, Peter E Keller
Research has demonstrated that the human cognitive system allocates attention most efficiently to a stimulus that occurs in synchrony with an established rhythmic background. However, our environment is dynamic and constantly changing. What happens when rhythms to which our cognitive system adapted disappear? We addressed this question using a visual categorization task comprising emotional and neutral faces. The task was split into three blocks of which the first and the last were completed in silence. The second block was accompanied by an acoustic background rhythm that, for one group of participants, was synchronous with face presentations, and for another group was asynchronous...
January 17, 2018: Psychological Research
https://www.readbyqxmd.com/read/29339318/dietary-patterns-body-mass-index-and-inflammation-pathways-to-depression-and-mental-health-problems-in-adolescents
#14
Wendy H Oddy, Karina L Allen, Georgina S A Trapp, Gina L Ambrosini, Lucinda J Black, Rae-Chi Huang, Peter Rzehak, Kevin C Runions, Feng Pan, Lawrence J Beilin, Trevor A Mori
BACKGROUND: Observational studies suggest that dietary patterns may impact mental health outcomes, although biologically plausible pathways are yet to be tested. We aimed to elucidate the longitudinal relationship between dietary patterns, adiposity, inflammation and mental health including depressive symptoms in a population-based cohort of adolescents. METHODS: Data were provided from 843 adolescents participating in the Western Australian Pregnancy Cohort (Raine) Study at 14 and 17 years (y) of age...
January 12, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29331850/attentional-biases-in-patients-suffering-from-unipolar-depression-results-of-a-dot-probe-task-investigation
#15
Wolfgang Trapp, Christoph Kalzendorf, Corinna Baum, Göran Hajak, Stefan Lautenbacher
Cognitive models of depression emphasize the relevance of cognitive biases for development, onset and maintenance of major depressive disorder (MDD). Attentional biases consisting of increased attention to negative, mood congruent stimuli and reduced attention to positive, mood-incongruent stimuli are postulated but have rarely been tested for early attentional processing. Furthermore, the role of concurrent depressive mood as a moderating factor has not been studied to date. Participants comprised 30 patients suffering from MDD and 30 healthy control subjects...
January 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29321556/the-water-alkane-interface-at-various-nacl-salt-concentrations-a-molecular-dynamics-study-of-the-readily-available-force-fields
#16
Thomas R Underwood, H Chris Greenwell
In this study, classical molecular dynamic simulations have been used to examine the molecular properties of the water-alkane interface at various NaCl salt concentrations (up to 3.0 mol/kg). A variety of different force field combinations have been compared against experimental surface/interfacial tension values for the water-vapour, decane-vapour and water-decane interfaces. Six different force fields for water (SPC, SPC/E, TIP3P, TIP3Pcharmm, TIP4P & TIP4P2005), and three further force fields for alkane (TraPPE-UA, CGenFF & OPLS) have been compared to experimental data...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320185/force-field-benchmark-of-the-trappe-ua-for-polar-liquids-density-heat-of-vaporization-dielectric-constant-surface-tension-volumetric-expansion-coefficient-and-isothermal-compressibility
#17
Edgar Núñez-Rojas, Jorge Alberto Aguilar-Pineda, Alexander Pérez de la Luz, Edith Nadir De Jesús González, Jose Alejandre
The transferable potential for phase equilibria force field in its united atom version, TraPPE UA, is evaluated for 41 polar liquids that include alcohols, thiols, ethers, sulfides, aldehydes, ketones and esters to determine its ability to reproduce experimental properties that were not included in the parametrization procedure. The intermolecular force field parameters for pure components were fit to reproduce experimental boiling temperature, vapor-liquid coexisting densities and critical point (temperature, density and pressure) using Monte Carlo simulations in different ensembles...
January 10, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29316930/feasibility-of-a-commercial-smartphone-application-for-dietary-assessment-in-epidemiological-research-and-comparison-with-24-h-dietary-recalls
#18
Gina L Ambrosini, Miriam Hurworth, Roslyn Giglia, Gina Trapp, Penelope Strauss
BACKGROUND: Dietary assessment methods that can provide high quality data while limiting participant burden and resource requirements in epidemiological research are highly sought after and continue to evolve. The use of mobile phone technology in research has increased rapidly over the last decade and offers multiple advantages to the researcher over traditional data collection methods. This study tested the acceptability and relative validity of a commercial smart phone application (app) for use as an epidemiological dietary assessment tool, compared with a traditional dietary assessment method...
January 9, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29278503/investigation-of-strain-promoted-azide-alkyne-cycloadditions-in-aqueous-solutions-by-capillary-electrophoresis
#19
Jana Steflova, Golo Storch, Sarah Wiesner, Skrollan Stockinger, Regina Berg, Oliver Trapp
The Cu-free 1,3-dipolar cycloaddition of cyclooctynes and azides is an up-and-coming method in bioorganic chemistry and other disciplines. However, broad application is still hampered by major drawbacks such as poor solubility of the reactants in aqueous media and low reaction rates. It is thus of high demand to devise a fast and user-friendly strategy for the optimization of reaction conditions and reagent design. We describe a capillary electrophoresis (CE) study of reaction kinetics in strain-promoted azide-alkyne cycloadditions (SPAAC) using substrates with acidic or basic functionalities...
December 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29274095/alterations-in-ca1-hippocampal-synapses-in-a-mouse-model-of-fragile-x-syndrome
#20
Safdar Jawaid, Grahame J Kidd, Jing Wang, Carrie Swetlik, Ranjan Dutta, Bruce D Trapp
Fragile X Syndrome (FXS) is the major cause of inherited mental retardation and the leading genetic cause of Autism spectrum disorders. FXS is caused by mutations in the Fragile X Mental Retardation 1 (Fmr1) gene, which results in transcriptional silencing of Fragile X Mental Retardation Protein (FMRP). To elucidate cellular mechanisms involved in the pathogenesis of FXS, we compared dendritic spines in the hippocampal CA1 region of adult wild-type (WT) and Fmr1 knockout (Fmr1-KO) mice. Using diolistic labeling, confocal microscopy, and three-dimensional electron microscopy, we show a significant increase in the diameter of secondary dendrites, an increase in dendritic spine density, and a decrease in mature dendritic spines in adult Fmr1-KO mice...
December 23, 2017: Glia
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