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https://www.readbyqxmd.com/read/30215581/identifying-a-new-subtype-of-multiple-sclerosis
#1
Bruce D Trapp, Daniel Ontaneda
Dr Bruce Trapp and Dr Daniel Ontaneda speak to Laura Dormer, Commissioning Editor: Bruce D Trapp, PhD, is a Chair of the Department of Neurosciences at the Lerner Research Institute, Cleveland Clinic (OH, USA) and Professor of Molecular Medicine at Case Western Reserve University (OH, USA). Dr Trapp received his PhD from Loyola University Stritch School of Medicine in Chicago (IL, USA). Dr Trapp's research investigates the cause of neurological disability in multiple sclerosis patients, cellular mechanism of brain repair in neurodegenerative diseases and the molecular biology of myelination in the central and peripheral nervous systems...
September 14, 2018: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/30161005/cardiovascular-and-skeletal-muscle-health-with-lifelong-exercise
#2
Kevin Joseph Gries, Ulrika Raue, Ryan K Perkins, Kaleen M Lavin, Brittany S Overstreet, Leonardo J D'Acquisto, Bruce Graham, W Holmes Finch, Leonard A Kaminsky, Todd A Trappe, Scott W Trappe
The purpose of this study was to examine the effects of lifelong aerobic exercise (LLE) on VO2 max and skeletal muscle metabolic fitness in trained females (n=7, 72±2y) and males (n=21, 74±1y), and compare them to old healthy non-exercisers (OH; females: n=10, 75±1y; males: n=10, 75±1y), and young exercisers (YE; females: n=10, 25±1y; males: n=10, 25±1y). LLE males were further subdivided based on intensity of lifelong exercise and competitive status into performance (LLE-P, n=14) and fitness (LLE-F, n=7)...
August 30, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/30152084/trappopathies-an-emerging-set-of-disorders-linked-to-variations-in-the-genes-encoding-transport-protein-particle-trapp-associated-proteins
#3
REVIEW
Michael Sacher, Nassim Shahrzad, Hiba Kamel, Miroslav P Milev
The movement of proteins between cellular compartments requires the orchestrated actions of many factors including Rab family GTPases, soluble NSF attachment protein receptors (SNAREs) and so-called tethering factors. One such tethering factor is called TRAPP, and in humans, TRAPP proteins are distributed into two related complexes called TRAPP II and III. Although thought to act as a single unit within the complex, in the past few years it has become evident that some TRAPP proteins function independently of the complex...
August 27, 2018: Traffic
https://www.readbyqxmd.com/read/30151227/what-is-known-about-consumer-nutrition-environments-in-australia-a-scoping-review-of-the-literature
#4
C E Pulker, L E Thornton, G S A Trapp
Objective: Food environments can influence food selection and hold the potential to reduce obesity, non-communicable diseases and their inequalities. 'Consumer nutrition environments' describe what consumers encounter within a food retail outlet, including products, price, promotion and placement. This study aimed to summarize the attributes that have been examined in existing peer-reviewed studies of Australian consumer nutrition environments, identify knowledge gaps and provide recommendations for future research...
August 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/30143361/cortical-neuronal-densities-and-cerebral-white-matter-demyelination-in-multiple-sclerosis-a-retrospective-study
#5
Bruce D Trapp, Megan Vignos, Jessica Dudman, Ansi Chang, Elizabeth Fisher, Susan M Staugaitis, Harsha Battapady, Sverre Mork, Daniel Ontaneda, Stephen E Jones, Robert J Fox, Jacqueline Chen, Kunio Nakamura, Richard A Rudick
BACKGROUND: Demyelination of cerebral white matter is thought to drive neuronal degeneration and permanent neurological disability in individuals with multiple sclerosis. Findings from brain MRI studies, however, support the possibility that demyelination and neuronal degeneration can occur independently. We aimed to establish whether post-mortem brains from patients with multiple sclerosis show pathological evidence of cortical neuronal loss that is independent of cerebral white-matter demyelination...
August 21, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30122163/development-of-an-advanced-derivatization-protocol-for-the-unambiguous-identification-of-monosaccharides-in-complex-mixtures-by-gas-and-liquid-chromatography
#6
Maren Haas, Saskia Lamour, Oliver Trapp
The separation and analysis of complex monosaccharide mixtures is highly challenging and requires typically carefully selected derivatization procedures to avoid changes in the sample composition. Here we present in a comparative study several single- and two-step derivatization approaches for LC and GC separations using a set of reference compounds ranging from C1 building block such as formaldehyde to C6 monosaccharides. Separation conditions have been optimized resulting in the simultaneous separation of 15 unbranched aldoses...
September 21, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/30120216/bi-allelic-mutations-in-trappc2l-result-in-a-neurodevelopmental-disorder-and-have-an-impact-on-rab11-in-fibroblasts
#7
Miroslav P Milev, Claudio Graziano, Daniela Karall, Willemijn F E Kuper, Noraldin Al-Deri, Duccio Maria Cordelli, Tobias B Haack, Katharina Danhauser, Arcangela Iuso, Flavia Palombo, Tommaso Pippucci, Holger Prokisch, Djenann Saint-Dic, Marco Seri, Daniela Stanga, Giovanna Cenacchi, Koen L I van Gassen, Johannes Zschocke, Christine Fauth, Johannes A Mayr, Michael Sacher, Peter M van Hasselt
BACKGROUND: The combination of febrile illness-induced encephalopathy and rhabdomyolysis has thus far only been described in disorders that affect cellular energy status. In the absence of specific metabolic abnormalities, diagnosis can be challenging. OBJECTIVE: The objective of this study was to identify and characterise pathogenic variants in two individuals from unrelated families, both of whom presented clinically with a similar phenotype that included neurodevelopmental delay, febrile illness-induced encephalopathy and episodes of rhabdomyolysis, followed by developmental arrest, epilepsy and tetraplegia...
August 17, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/30109035/mapping-movement-mood-motivation-and-mentation-in-the-subthalamic-nucleus
#8
Amritha Gourisankar, Sarah A Eisenstein, Nicholas T Trapp, Jonathan M Koller, Meghan C Campbell, Mwiza Ushe, Joel S Perlmutter, Tamara Hershey, Kevin J Black
The anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) contributes to the variability of motor and non-motor responses across patients with Parkinson's disease (PD). We previously tested the hypothesis using a three-dimensional (3D) statistical method to interpret the acute effects of unilateral DBS at each patient's clinically optimized DBS settings and active contact...
July 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30103282/supramolecular-chirality-transfer-in-a-stereodynamic-catalysts
#9
Golo Storch, Oliver Trapp
We present rhodium catalysts that contain stereodynamic axially chiral biphenol-derived phosphinite ligands modified with non-stereoselective amides for non-covalent interactions. A chirality transfer was achieved with (R)- or (S)-acetylphenylalanine methyl amide, and the interaction mechanism was investigated by NMR measurements. These interactions at the non-stereoselective interaction sites and the formation of supramolecular complexes result in an enrichment of either the (Rax )- or (Sax ) enantiomer of the tropos catalysts, which in turn provide the (R)- or (S)-acetylphenylalanine methyl ester in the hydrogenation of (Z)-methyl-α-acetamidocinnamate...
October 2018: Chirality
https://www.readbyqxmd.com/read/30080609/atbet5-is-essential-for-exine-pattern-formation-and-apical-meristem-organization-in-arabidopsis
#10
Jin Zhang, Jun Chen, Lijuan Wang, Shutang Zhao, Jianbo Li, Bobin Liu, Hongying Li, Xingyun Qi, Huanquan Zheng, Mengzhu Lu
BET5 is a component of trafficking protein particle (TRAPP) which has been studied extensively in non-plant organisms where they are involved in membrane trafficking within Golgi and between Golgi and early endosomes. Recent analysis of TRAPP in different classes of organisms indicates that TRAPP function might exhibit differences among organisms. A single copy of the BET5 gene named AtBET5 was found in the Arabidopsis genome based on sequence similarity. Developmental phenotype and the underlying mechanisms have been characterized upon transcriptional knock-down lines generated by both T-DNA insertion and RNAi...
September 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/30077097/rapid-charge-variant-analysis-of-monoclonal-antibodies-to-support-lead-candidate-biopharmaceutical-development
#11
Anne Trappe, Florian Füssl, Sara Carillo, Izabela Zaborowska, Paula Meleady, Jonathan Bones
Biopharmaceuticals are complex therapeutic proteins produced in living cells that undergo a variety of enzymatic and non-enzymatic posttranslational modifications both intracellularly and also following secretion into the condition media. Characterization of these posttranslational modifications is a regulatory requirement to ensure that the molecule meets the required levels of quality to ensure patient safety. Ion exchange chromatography, particularly cation exchange, is routinely used for the determination of the charge variant profile of monoclonal antibodies (mAbs) using either an increasing concentration of salt or the generation of a pH gradient to facilitate elution of the mAb charge variants from the cation exchange phase...
September 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/30061053/lateral-cerebellar-nucleus-stimulation-promotes-motor-recovery-and-suppresses-neuroinflammation-in-a-fluid-percussion-injury-rodent-model
#12
Hugh H Chan, Connor A Wathen, Nicole D Mathews, Olivia Hogue, James P Modic, Ronak Kundalia, Cara Wyant, Hyun-Joo Park, Imad M Najm, Bruce D Trapp, Andre G Machado, Kenneth B Baker
BACKGROUND: Many traumatic brain injury (TBI) survivors live with persistent disability from chronic motor deficits despite contemporary rehabilitation services, underscoring the need for novel treatment. OBJECTIVE/HYPOTHESIS: We have previously shown that deep brain stimulation (DBS) of the lateral cerebellar nucleus (LCN) can enhance post-stroke motor recovery and increase the expression of markers of long-term potentiation in perilesional cerebral cortex. We hypothesize that a similar beneficial effect will be for motor deficits induced by unilateral fluid percussion injury (FPI) in rodents through long-term potentiation- and anti-inflammatory based mechanisms...
July 25, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/30024749/how-to-design-for-a-tailored-subcellular-distribution-of-systemic-agrochemicals-in-plant-tissues
#13
Sandro Hofstetter, Andreas Beck, Stefan Trapp, Anke Buchholz
Foliar-applied systemic agrochemicals require entrance into the plant vascular system or into specific subcellular compartments to reach their target in planta or to be imbibed by piercing/sucking pests. An inappropriate subcellular localization, like accumulation of aphicides in vacuoles, might lower the compound's efficiency due to reduced exposure to the target. Permeabilities and mass distributions of 16 compounds covering a broad range of properties were measured across a pH gradient in a PAMPA ("parallel artificial membrane permeability assay") system, providing experimental evidence for ion trapping of acids and bases in basic and acidic compartments, respectively...
August 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30019398/glp-1-neurons-form-a-local-synaptic-circuit-within-the-rodent-nucleus-of-the-solitary-tract
#14
J Patrick Card, Aaron L Johnson, Ida J Llewellyn-Smith, Huiyuan Zheng, Rishi Anand, Daniel I Brierley, Stefan Trapp, Linda Rinaman
Glutamatergic neurons that express pre-proglucagon (PPG) and are immunopositive (+) for glucagon-like peptide-1 (i.e., GLP-1+ neurons) are located within the caudal nucleus of the solitary tract (cNTS) and medullary reticular formation in rats and mice. GLP-1 neurons give rise to an extensive central network in which GLP-1 receptor (R) signaling suppresses food intake, attenuates rewarding, increases avoidance, and stimulates stress responses, partly via . GLP-1R signaling within the cNTS. In mice, noradrenergic (A2) cNTS neurons express GLP-1R, whereas PPG neurons do not...
July 17, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/30001483/online-high-throughput-measurements-for-fast-catalytic-reactions-using-time-division-multiplexing-gas-chromatography
#15
Marco R Wunsch, Rudolf Lehnig, Christiane Janke, Oliver Trapp
Developing new catalysts is crucial for optimization of chemical processes. Thus, advanced analytical methods are required to determine the catalytic performance of new catalysts accurately. Usually, gas chromatographic methods are employed to analyze quantitatively the product distribution of volatile compounds generated by a specific catalyst. However, the characterization of rapidly changing catalysts, e.g., due to deactivation, still poses an analytical challenge because gas chromatographic methods are too slow for monitoring the change of the complex product spectra...
August 7, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29994799/expression-of-peripheral-node-addressins-by-plasmacytic-plaque-of-children-apache-trapp-and-primary-cutaneous-angioplasmacellular-hyperplasia
#16
Angel Fernandez-Flores, José M Suarez Peñaranda, Gonzalo De Toro, Cesar C Alvarez Cuesta, Maria T Fernández-Figueras, Werner Kempf, Carlos Monteagudo
High-endothelial venules are a common feature of 3 types of cutaneous pseudolymphomas: pretibial lymphoplasmacytic plaque (PLP) of children, acral pseudolymphomatous angiokeratoma of children (APACHE), and T-cell rich angiomatoid polypoid pseudolymphoma (TRAPP). In addition, primary cutaneous angioplasmacellular hyperplasia (PCAH) overlaps with these other 3 conditions. We intend to study the expression of peripheral node addressins in PLP, APACHE, TRAPP, and PCAH. We studied 1 case of PLP, 2 cases of APACHE, 2 cases of TRAPP, and 2 cases of PCAH...
July 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29988987/hyperspectral-imaging-to-characterize-plant-plant-communication-in-response-to-insect-herbivory
#17
Leandro do Prado Ribeiro, Adriana Lídia Santana Klock, João Américo Wordell Filho, Marco Aurélio Tramontin, Marília Almeida Trapp, Axel Mithöfer, Christian Nansen
Background: In studies of plant stress signaling, a major challenge is the lack of non-invasive methods to detect physiological plant responses and to characterize plant-plant communication over time and space. Results: We acquired time series of phytocompound and hyperspectral imaging data from maize plants from the following treatments: (1) individual non-infested plants, (2) individual plants experimentally subjected to herbivory by green belly stink bug (no visible symptoms of insect herbivory), (3) one plant subjected to insect herbivory and one control plant in a separate pot but inside the same cage, and (4) one plant subjected to insect herbivory and one control plant together in the same pot...
2018: Plant Methods
https://www.readbyqxmd.com/read/29985455/neuroimaging-results-suggest-the-role-of-prediction-in-cross-domain-priming
#18
Catarina Amado, Petra Kovács, Rebecca Mayer, Géza Gergely Ambrus, Sabrina Trapp, Gyula Kovács
The repetition of a stimulus leads to shorter reaction times as well as to the reduction of neural activity. Previous encounters with closely related stimuli (primes) also lead to faster and often to more accurate processing of subsequent stimuli (targets). For instance, if the prime is a name, and the target is a face, the recognition of a persons' face is facilitated by prior presentation of his/her name. A possible explanation for this phenomenon is that the prime allows predicting the occurrence of the target...
July 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29984526/single-crystal-to-single-crystal-scsc-linear-polymerization-of-a-desymmetrized-anthraphane
#19
Marco Servalli, Nils Trapp, A Dieter Schlüter
In this work we present one of the rare cases of single-crystal-to-single-crystal (SCSC) linear polymerizations, resulting in a novel ladder-type polymer. The polymerization is based on the photoinduced [4+4]-cycloaddition reactions between trifunctional anthracene-based monomers. The careful design of the monomer anthraphane-tri(OMe), results in perfectly stacked anthracene pairs in the crystal structure, with Schmidt's distances d=3.505-3.666 Å and shift s=1.109 Å, allowing a selective linear polymerization in quantitative yields and in a matter of minutes, without compromising the integrity of the single crystals...
July 8, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29972071/the-role-of-the-built-environment-on-health-across-the-life-course-a-call-for-collaboraction
#20
Andrea Nathan, Karen Villanueva, Julianna Rozek, Melanie Davern, Lucy Gunn, Gina Trapp, Claire Boulangé, Hayley Christian
No abstract text is available yet for this article.
July 2018: American Journal of Health Promotion: AJHP
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