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Sandro Hofstetter, Andreas Beck, Stefan Trapp, Anke Buchholz
Foliar applied systemic agrochemicals require the entrance into the plant vascular system or into specific subcellular compartments to reach their target in planta or to be imbibed by piercing-sucking pests. An inappropriate subcellular localization, like accumulation of aphicides in vacuoles, might lower compound efficiency due to reduced exposure to the target. Permeabilities and mass distributions of sixteen compounds covering a broad range of properties were measured across a pH gradient in a PAMPA ('Parallel artificial membrane permeability assay') system, providing experimental evidence for ion trapping of acids and bases in basic and acidic compartments, respectively...
July 19, 2018: Journal of Agricultural and Food Chemistry
J Patrick Card, Aaron L Johnson, Ida J Llewellyn-Smith, Huiyuan Zheng, Rishi Anand, Daniel I Brierley, Stefan Trapp, Linda Rinaman
Glutamatergic neurons that express pre-proglucagon (PPG) and are immunopositive (+) for glucagon-like peptide-1 (i.e., GLP-1+ neurons) are located within the caudal nucleus of the solitary tract (cNTS) and medullary reticular formation in rats and mice. GLP-1 neurons give rise to an extensive central network in which GLP-1 receptor (R) signaling suppresses food intake, attenuates rewarding, increases avoidance, and stimulates stress responses, partly via . GLP-1R signaling within the cNTS. In mice, noradrenergic (A2) cNTS neurons express GLP-1R, whereas PPG neurons do not...
July 17, 2018: Journal of Comparative Neurology
Marco Robert Wunsch, Rudolf Lehnig, Christiane Janke, Oliver Trapp
Developing new catalysts is crucial for optimization of chemical processes. Thus, advanced analytical methods are required to determine the catalytic performance of new catalysts accurately. Usually, gas chromatographic methods are employed to analyze quantitatively the product distribution of volatile compounds generated by a specific catalyst. However, the characterization of rapidly changing catalysts, e.g. due to deactivation, still poses an analytical challenge because gas chromatographic methods are too slow for monitoring the change of the complex product spectra...
July 12, 2018: Analytical Chemistry
Angel Fernandez-Flores, José M Suarez Peñaranda, Gonzalo De Toro, Cesar C Alvarez Cuesta, Maria T Fernández-Figueras, Werner Kempf, Carlos Monteagudo
High-endothelial venules are a common feature of 3 types of cutaneous pseudolymphomas: pretibial lymphoplasmacytic plaque (PLP) of children, acral pseudolymphomatous angiokeratoma of children (APACHE), and T-cell rich angiomatoid polypoid pseudolymphoma (TRAPP). In addition, primary cutaneous angioplasmacellular hyperplasia (PCAH) overlaps with these other 3 conditions. We intend to study the expression of peripheral node addressins in PLP, APACHE, TRAPP, and PCAH. We studied 1 case of PLP, 2 cases of APACHE, 2 cases of TRAPP, and 2 cases of PCAH...
July 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Leandro do Prado Ribeiro, Adriana Lídia Santana Klock, João Américo Wordell Filho, Marco Aurélio Tramontin, Marília Almeida Trapp, Axel Mithöfer, Christian Nansen
Background: In studies of plant stress signaling, a major challenge is the lack of non-invasive methods to detect physiological plant responses and to characterize plant-plant communication over time and space. Results: We acquired time series of phytocompound and hyperspectral imaging data from maize plants from the following treatments: (1) individual non-infested plants, (2) individual plants experimentally subjected to herbivory by green belly stink bug (no visible symptoms of insect herbivory), (3) one plant subjected to insect herbivory and one control plant in a separate pot but inside the same cage, and (4) one plant subjected to insect herbivory and one control plant together in the same pot...
2018: Plant Methods
Catarina Amado, Petra Kovács, Rebecca Mayer, Géza Gergely Ambrus, Sabrina Trapp, Gyula Kovács
The repetition of a stimulus leads to shorter reaction times as well as to the reduction of neural activity. Previous encounters with closely related stimuli (primes) also lead to faster and often to more accurate processing of subsequent stimuli (targets). For instance, if the prime is a name, and the target is a face, the recognition of a persons' face is facilitated by prior presentation of his/her name. A possible explanation for this phenomenon is that the prime allows predicting the occurrence of the target...
July 9, 2018: Scientific Reports
Marco Servalli, Nils Trapp, Dieter Schlüter
In this work we present one of the rare cases of single-crystal-to-single-crystal (SCSC) linear polymerizations, resulting in a novel ladder-type polymer. The polymerization is based on the photoinduced [4+4]-cycloaddition reactions between trifunctional anthracene-based monomers. The careful design of the monomer anthraphane-tri(OMe), results in perfectly stacked anthracene pairs in the crystal structure, with Schmidt's distances d = 3.505-3.666 Å and shift s = 1.109 Å, allowing a selective linear polymerization in quantitative yields and in a matter of minutes, without compromising the integrity of the single crystals...
July 8, 2018: Chemistry: a European Journal
Andrea Nathan, Karen Villanueva, Julianna Rozek, Melanie Davern, Lucy Gunn, Gina Trapp, Claire Boulangé, Hayley Christian
No abstract text is available yet for this article.
July 2018: American Journal of Health Promotion: AJHP
Benjamin Sasko, Ulrich Thiem, Martin Christ, Hans-Joachim Trappe, Oliver Ritter, Nikolaos Pagonas
PURPOSE: Acute lung injury is a life threatening condition often requiring mechanical ventilation. Lung-protective ventilation with tidal volumes of 6 mL/kg predicted body weight (PBW, calculated on the basis of a patient's sex and height), is part of current recommended ventilation strategy. Hence, an exact height is necessary to provide optimal mechanical ventilation. However, it is a common practice to visually estimate the body height of mechanically ventilated patients and use these estimates as a reference size for ventilator settings...
2018: PloS One
James Rijken, Barry Jordan, Scott Crowe, Tanya Kairn, Jamie Trapp
PURPOSE: Use of SBRT techniques is now a relatively common recourse for spinal metastases due to good local control rates and durable pain control. However, the technique has not yet reached maturity for gantry-based systems, so work is still required in finding planning approaches that produce optimum conformity as well as delivery for the slew of treatment planning systems and treatment machines. METHODS: A set of 32 SBRT spine treatment plans based on four vertebral sites, varying in modality and number of control points, were created in Pinnacle...
June 26, 2018: Journal of Applied Clinical Medical Physics
James Rijken, Tanya Kairn, Scott Crowe, Luis Muñoz, Jamie Trapp
PURPOSE: The ability to accurately predict skin doses and thereby design radiotherapy treatments that balance the likelihood of skin reactions against other treatment objectives is especially important when hypofractionated prescription regimes are used. However, calculations of skin dose provided by many commercial radiotherapy treatment planning systems are known to be inaccurate, especially if the presence of immobilization equipment is not accurately taken into account. This study proposes a simple method by which the accuracy of skin dose calculations can be substantially improved, to allow informed evaluation of volumetric modulated arc therapy (VMAT) treatment plans...
June 22, 2018: Journal of Applied Clinical Medical Physics
Zia Ud Din, Marilia Almeida Trapp, Lívia Soman de Medeiros, Danielle Lazarin-Bidóia, Francielle Pelegrin Garcia, Francieli Peron, Celso Vataru Nakamura, Ihosvany Camps Rodríguez, Abdul Wadood, Edson Rodrigues-Filho
Symmetrical and unsymmetrical bis-aryl-α,β-unsaturated ketones were synthesized in moderate to excellent yield by treating cyclohexanone with various aldehydes. Dimethylammonium dimethylcarbamate (DIMCARB) was used as both catalyst and reaction medium for the synthesis of monoarylidenes cycloadduct intermediates, which was further used to produce diarylidene cyclohexanones. All the 34 compounds synthesized were evaluated for their anti-proliferative activity, particularly against promastigote of Leishmania amazonensis, epimastigoteand trypomastigoteof Trypanosoma cruzi...
June 14, 2018: European Journal of Medicinal Chemistry
Naji C Salloum, Erica Lf Buchalter, Swati Chanani, Gemma Espejo, Mahjabeen S Ismail, Randy O Laine, Maysaa Nageeb, A Benjamin Srivastava, Nicholas Trapp, Ludwig Trillo, Erica Vance, Michael Wenzinger, Sarah M Hartz, Sean P David, Li-Shiun Chen
Smoking cessation treatment outcomes may be heavily influenced by genetic variations among smokers. Therefore, identifying specific variants that affect response to different pharmacotherapies is of major interest to the field. In the current study, we systematically review all studies published in or after the year 1990 which examined one or more gene-drug interactions for smoking cessation treatment. Out of 644 citations, 46 articles met the inclusion criteria for the systematic review. We summarize evidence on several genetic polymorphisms (CHRNA5-A3-B4, CYP2A6, DBH, CHRNA4, COMT, DRD2, DRD4 and CYP2B6) and their potential moderating pharamacotherarpy effects on patient cessation efficacy rates...
July 1, 2018: Pharmacogenomics
Sarah Foster, Paula Hooper, Matthew Knuiman, Leanne Lester, Georgina Trapp
The prevalence of warehouse-style liquor stores has prompted alarm from local communities and public health advocates. To increase local government control over liquor stores, one proposed planning response is to distinguish between 'small' (i.e., ≤ 300 m2 ) and 'large' (i.e., > 300 m2 ) liquor stores. We mapped the size and location of liquor stores in Perth, Western Australia, and tested associations between liquor store exposure and alcohol consumption (grams ethanol/day) in young adults (n = 990)...
June 15, 2018: Health & Place
Annamária Sepsey, Dóra Rita Németh, Gábor Németh, Attila Felinger
It may happen under the conditions employed that enantiomers interconvert to each other. In this case, obviously, the kinetics of the process is to be examined. When enantiomers dynamically interconvert to each other during the separation process, a plateau is observed between the adjacent peaks (so-called Batman peak appears). The peak shape depends on the rate constant of this dynamic reaction. A novel stochastic model was derived which takes both the separation and the interconversion into account at the molecular level - thus the effects of the parameters affecting the separation can be investigated...
June 6, 2018: Journal of Chromatography. A
Philip Trapp, Rodrigo Echeveste, Claudius Gros
Spontaneous brain activity is characterized in part by a balanced asynchronous chaotic state. Cortical recordings show that excitatory (E) and inhibitory (I) drivings in the E-I balanced state are substantially larger than the overall input. We show that such a state arises naturally in fully adapting networks which are deterministic, autonomously active and not subject to stochastic external or internal drivings. Temporary imbalances between excitatory and inhibitory inputs lead to large but short-lived activity bursts that stabilize irregular dynamics...
June 12, 2018: Scientific Reports
Sebastian Pallmann, Alexander F Siegle, Jana Šteflová, Oliver Trapp
We report the first successful implementation of a multiplexing method on a standard capillary electrophoresis system with UV detection that is independent of additional hardware. This was achieved using the Hadamard transform approach and employing vial exchange and voltage suspensions for translation of pseudorandom binary sequence elements into sample and background electrolyte injections of a capillary zone electrophoresis separation. Sequences exceeding peak capacity of the capillary were subdivided into shorter subsequences measured successively and realigned afterward based on EOF marker or analyte peaks...
July 17, 2018: Analytical Chemistry
Kaspar Staub, Joël Floris, Nikola Koepke, Adrian Trapp, Andreas Nacht, Susanna Schärli Maurer, Frank J Rühli, Nicole Bender
OBJECTIVES: To assess the benefit of waist circumference (WC) measurements during routine conscription medical examination in two military conscription centres in Switzerland. We compared the prevalence of overweight and obesity assessed by body mass index (BMI) with the prevalence of elevated disease risks assessed by WC and waist-to-height ratio (WHtR). We investigated how these measures were associated with systolic blood pressure, physical fitness performance and socioeconomic determinants...
June 9, 2018: BMJ Open
Wolfgang Langhans, Roger Adan, Myrtha Arnold, William A Banks, J Patrick Card, Megan J Dailey, Derek Daniels, Annette D de Kloet, Guillaume de Lartigue, Suzanne Dickson, Shahana Fedele, Harvey J Grill, John-Olov Jansson, Sharon Kaufman, Grant Kolar, Eric Krause, Shin J Lee, Christelle Le Foll, Barry E Levin, Thomas A Lutz, Abdelhak Mansouri, Timothy H Moran, Gustavo Pacheco-López, Deepti Ramachandran, Helen Raybould, Linda Rinaman, Willis K Samson, Graciela Sanchez-Watts, Randy J Seeley, Karolina P Skibicka, Dana Small, Alan C Spector, Kellie L Tamashiro, Brian Templeton, Stefan Trapp, Patrick Tso, Alan G Watts, Nadja Weissfeld, Diana Williams, Christian Wolfrum, Gina Yosten, Stephen C Woods
No abstract text is available yet for this article.
May 12, 2018: Molecular Metabolism
Alexia Bivoltsis, Eleanor Cervigni, Gina Trapp, Matthew Knuiman, Paula Hooper, Gina Leslie Ambrosini
BACKGROUND: The relationships between food environments and dietary intake have been assessed via a range of methodologically diverse measures of spatial exposure to food outlets, resulting in a largely inconclusive body of evidence, limiting informed policy intervention. OBJECTIVE: This systematic review aims to evaluate the influence of methodological choice on study outcomes by examining the within-study effect of availability (e.g., counts) versus accessibility (e...
June 9, 2018: International Journal of Health Geographics
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