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https://www.readbyqxmd.com/read/27898809/sequence-based-introgression-mapping-identifies-candidate-white-mold-tolerance-genes-in-common-bean
#1
Sujan Mamidi, Phillip N Miklas, Jennifer Trapp, Erin Felicetti, Jane Grimwood, Jeremy Schmutz, Rian Lee, Phillip E McClean
White mold, caused by the necrotrophic fungus (Lib.) de Bary, is a major disease of common bean ( L.). WM7.1 and WM8.3 are two quantitative trait loci (QTL) with major effects on tolerance to the pathogen. Advanced backcross populations segregating individually for either of the two QTL, and a recombinant inbred (RI) population segregating for both QTL were used to fine map and confirm the genetic location of the QTL. The QTL intervals were physically mapped using the reference common bean genome sequence, and the physical intervals for each QTL were further confirmed by sequence-based introgression mapping...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27881626/reply-to-venturelli-and-colleagues
#2
Greg J Grosicki, Robert A Standley, Kevin A Murach, Ulrika Raue, Kiril Minchev, Paul M Coen, Stephen Kritchevsky, Bret H Goodpaster, Scott Trappe
No abstract text is available yet for this article.
November 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27872255/proteolipid-protein-deficient-myelin-promotes-axonal-mitochondrial-dysfunction-via-altered-metabolic-coupling
#3
Xinghua Yin, Grahame J Kidd, Nobuhiko Ohno, Guy A Perkins, Mark H Ellisman, Chinthasagar Bastian, Sylvain Brunet, Selva Baltan, Bruce D Trapp
Hereditary spastic paraplegia (HSP) is a neurological syndrome characterized by degeneration of central nervous system (CNS) axons. Mutated HSP proteins include myelin proteolipid protein (PLP) and axon-enriched proteins involved in mitochondrial function, smooth endoplasmic reticulum (SER) structure, and microtubule (MT) stability/function. We characterized axonal mitochondria, SER, and MTs in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein, P0 (P0-CNS mice). Mitochondrial pathology and degeneration were prominent in juxtaparanodal axoplasm at 1 mo of age...
November 21, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27872253/gtpase-cross-talk-regulates-trappii-activation-of-rab11-homologues-during-vesicle-biogenesis
#4
Laura L Thomas, J Christopher Fromme
Rab guanosine triphosphatases (GTPases) control cellular trafficking pathways by regulating vesicle formation, transport, and tethering. Rab11 and its paralogs regulate multiple secretory and endocytic recycling pathways, yet the guanine nucleotide exchange factor (GEF) that activates Rab11 in most eukaryotic cells is unresolved. The large multisubunit transport protein particle (TRAPP) II complex has been proposed to act as a GEF for Rab11 based on genetic evidence, but conflicting biochemical experiments have created uncertainty regarding Rab11 activation...
November 21, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27867107/draft-genome-sequence-of-mentha-longifolia-l-and-development-of-resources-for-mint-cultivar-improvement
#5
Kelly J Vining, Sean R Johnson, Amirhossein Ahkami, Iris Lange, Amber N Parrish, Susan C Trapp, Rodney B Croteau, Shannon C K Straub, Iovanna Pandelova, B Markus Lange
The genus Mentha encompasses species cultivated for their essential oils, which are formulated into a vast array of consumer products. Desirable oil characteristics and resistance to the fungal disease Verticillium wilt are top priorities for the mint industry. However, cultivated mints have complex polyploid genomes and are sterile. Breeding efforts, therefore, require the development of genomic resources for fertile mint species. Here, we present draft de novo genome and plastome assemblies for a wilt-resistant South African accession of Mentha longifolia (L...
November 17, 2016: Molecular Plant
https://www.readbyqxmd.com/read/27842981/effect-of-verification-imaging-on-in-vivo-dosimetry-results-using-gafchromic-ebt3-film
#6
Trent Aland, Rebecca Moylan, Tanya Kairn, Jamie Trapp
In this work, the apparent treatment dose that kV planar or CBCT imaging contributes to Gafchromic EBT3 film used for in vivo dosimetry, was investigated. Gafchromic EBT3 film pieces were attached to a variety of phantoms and irradiated using the linear accelerator's built-in kV imaging system, in both kV planar mode and CBCT mode. To evaluate the sensitivity of the film in the clinical scenario where dose contributions are received from both imaging and treatment, additional pieces of film were irradiated using base doses of 50cGy and then irradiated using selected kV planar and CBCT techniques...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27826439/a-prospective-investigation-of-dietary-patterns-and-internalizing-and-externalizing-mental-health-problems-in-adolescents
#7
Georgina S A Trapp, Karina L Allen, Lucinda J Black, Gina L Ambrosini, Peter Jacoby, Susan Byrne, Karen E Martin, Wendy H Oddy
Investigating protective and risk factors that influence mental health in young people is a high priority. While previous cross-sectional studies have reported associations between diet and mental health among adolescents, few prospective studies exist. The aim of this study was to examine prospective relationships between dietary patterns and mental health among adolescents participating in the Western Australian Pregnancy Cohort (Raine) Study. Self-report questionnaires were used to assess indicators of mental health (Youth Self-Report externalizing/internalizing T-scores) and Western and Healthy dietary patterns (identified using factor analysis) at 14 (2003-2005) and 17 years (2006-2008)...
November 2016: Food Science & Nutrition
https://www.readbyqxmd.com/read/27807523/effect-of-concurrent-resistance-and-sprint-training-on-body-composition-and-cardiometabolic-health-indicators-in-masters-cyclists
#8
Luke Delvecchio, Peter Reaburn, Gail Trapp, Marko T Korhonen
In older previously sedentary individuals endurance training imposes a more effective stimulus to enhance cardiometabolic health compared with resistance or sprint training. We examined the effect of replacing a portion of endurance training with combined resistance and/or sprint training and how this influences cardiometabolic health indicators in masters endurance cyclists. Twenty-seven well-trained male road cyclists (53.7±8.2 years) were allocated to a resistance and track sprint-cycling training group (RTC, n=10), an endurance and track sprint-cycling group (ETC, n=7) or a control endurance group (CTRL, n=10)...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27802707/bioref-ii-neutron-reflectometry-with-relaxed-resolution-for-fast-kinetic-measurements-at-hzb
#9
M Trapp, R Steitz, M Kreuzer, M Strobl, M Rose, R Dahint
We present an upgrade to the time-of-flight neutron reflectometer BioRef at the research reactor BER II of the Helmholtz-Zentrum Berlin für Materialien und Energie (HZB). Through the integration of an additional chopper into the existing setup, the available wavelength resolution is significantly extended. Now two distinct operation modes can be used: a high resolution mode with Δλ/λ ranging from 1% to 5%, which allows for the investigation of thick films up to 4000 Å, and a high flux mode with Δλ/λ = 7%-11%...
October 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27798189/a-decline-in-response-variability-improves-neural-signal-detection-during-auditory-task-performance
#10
Gardiner von Trapp, Bradley N Buran, Kamal Sen, Malcolm N Semple, Dan H Sanes
: The detection of a sensory stimulus arises from a significant change in neural activity, but a sensory neuron's response is rarely identical to successive presentations of the same stimulus. Large trial-to-trial variability would limit the central nervous system's ability to reliably detect a stimulus, presumably affecting perceptual performance. However, if response variability were to decrease while firing rate remained constant, then neural sensitivity could improve. Here, we asked whether engagement in an auditory detection task can modulate response variability, thereby increasing neural sensitivity...
October 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27791317/a-stereodynamic-phosphoramidite-ligand-derived-from-3-3-functionalized-ortho-biphenol-and-its-rhodium-i-complex
#11
Golo Storch, Luisa Deberle, Jan-Michael Menke, Frank Rominger, Oliver Trapp
Stereodynamic ligands and complexes bearing functional groups to attach chiral or achiral binding sites and auxiliaries are highly attractive due to the interesting opportunities for controlling the stereochemical outcome of enantioselective transformations. In this study we report the preparation of a 3,3'-functionalized biphenol (BIPOL) phosphoramidite ligand (PAm ) bearing 3,5-dichlorobenzoyl (3,5-DCB) amide binding sites for noncovalent interactions. Upon coordination to [Rh(COD)2 ]BF4 this substitution pattern directs one of the 3,5-DCB binding sites in close proximity of the metal center resulting in liberation of both COD ligands and the formation of a [Rh(PAm )2 ]BF4 complex...
November 2016: Chirality
https://www.readbyqxmd.com/read/27787758/investigating-the-use-of-image-thresholding-in-brachytherapy-catheter-reconstruction
#12
Diana Binny, Craig M Lancaster, Tanya Kairn, Jamie V Trapp, Phil Back, Robyn Cheuk, Scott B Crowe
This study evaluated the accuracy of image thresholding in the reconstruction of catheters in brachytherapy treatment planning systems. Six test cases including four planar catheter configurations, an interstitial prostate and an intracavitary treatment plan were made use of in this study. The four planar CT scanned catheter arrangements included; catheters placed approximately 1, 0.5 cm apart, catheters closely arranged in a plan (<0.5 cm apart) and a loop arrangement. The intracavitary plan consisted of catheters arranged inside a mould configuration...
October 27, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27782733/technical-note-calibrating-radiochromic-film-in-beams-of-uncertain-quality
#13
Samuel C Peet, Rachael Wilks, Tanya Kairn, Jamie V Trapp, Scott B Crowe
PURPOSE: The dose-response of radiochromic film has been shown to be dependent on the quality of the incident radiation, particularly at low energies. Difficulty therefore arises when a calibration is required for radiation of uncertain energy. This study investigates the ability of a recently published calibration method [see M. Tamponi et al., "A new form of the calibration curve in radiochromic dosimetry. Properties and results," Med. Phys. 43, 4435-4446 (2016)] to reduce the energy-dependence of radiochromic film...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27746215/developmental-hearing-loss-impedes-auditory-task-learning-and-performance-in-gerbils
#14
Gardiner von Trapp, Ishita Aloni, Stephen Young, Malcolm N Semple, Dan H Sanes
The consequences of developmental hearing loss have been reported to include both sensory and cognitive deficits. To investigate these issues in a non-human model, auditory learning and asymptotic psychometric performance were compared between normal hearing (NH) adult gerbils and those reared with conductive hearing loss (CHL). At postnatal day 10, before ear canal opening, gerbil pups underwent bilateral malleus removal to induce a permanent CHL. Both CHL and control animals were trained to approach a water spout upon presentation of a target (Go stimuli), and withhold for foils (Nogo stimuli)...
October 13, 2016: Hearing Research
https://www.readbyqxmd.com/read/27739781/impact-of-volume-transition-on-the-net-charge-of-poly-n-isopropyl-acrylamide-microgels
#15
M Braibanti, C Haro-Pérez, M Quesada-Pérez, L F Rojas-Ochoa, V Trappe
We explore the electrostatic properties of poly-N-isopropyl acrylamide microgels in dilute, quasi-de-ionized dispersions and show that the apparent net charge of these thermosensitive microgels is an increasing function of their size, the size being conveniently varied by temperature. Our experimental results obtained in a combination of light scattering, conductivity, and mobility experiments are consistent with those obtained in Poisson-Boltzmann cell model calculations, effectively indicating that upon shrinking the number of counterions entrapped within the microgels increases...
September 2016: Physical Review. E
https://www.readbyqxmd.com/read/27739233/alleno-acetylenic-cage-aac-receptors-chiroptical-switching-and-enantioselective-complexation-of-trans-1-2-dimethylcyclohexane-in-a-diaxial-conformation
#16
Cornelius Gropp, Nils Trapp, François Diederich
Four enantiopure 1,3-diethynylallenes (DEAs) with OH termini were attached to the rim of a resorcin[4]arene cavitand. The system undergoes conformational switching between a cage form, closed by a circular H-bonding array, and an open form, with the tertiary alcohol groups reaching outwards. The cage form is predominant in apolar solvents, and the open conformation in small, polar solvents. Both states were confirmed in solution and in X-ray co-crystal structures. ECD spectra of the alleno-acetylenic cages (AACs) are highly conformation sensitive, the longest wavelength Cotton effect at 304 nm switches from Δϵ=+191 m(-1)  cm(-1) for open (P)4 -AAC⊂acetonitrile to Δϵ=-691 m(-1)  cm(-1) (ΔΔϵ=882 m(-1)  cm(-1) ) for closed (P)4 -AAC⊂cyclohexane...
October 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27738753/-predictors-for-need-of-antibradycardia-and-antitachycardia-pacing-after-icd-implantation-implications-for-the-subcutaneous-icd
#17
Martin Grett, Martin Christ, Hans-Joachim Trappe
BACKGROUND: Little is known about the incidence and risk factors for progression to pacemaker dependency or the need for cardiac resynchronization in typical patients with an implanted defibrillator with regard to an alternative implantation of a subcutaneous ICD (S-ICD). STUDY DESIGN AND METHODS: After retrospective analysis of 291 patients with first implantation of a transvenous single chamber ICD (VVI-ICD) from 2010-2016 and excluding those with an indication for pacemaker or lack of follow-up data, 121 patients were included and investigated with regard to the following endpoints: need for pacemaker stimulation, upgrade for cardiac resynchronization (CRT), and secondary occurrence and effectiveness of antitachycardia pacing (ATP)...
October 13, 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27732057/establishment-of-the-pediatric-obesity-weight-evaluation-registry-a-national-research-collaborative-for-identifying-the-optimal-assessment-and-treatment-of-pediatric-obesity
#18
Shelley Kirk, Sarah Armstrong, Eileen King, Christine Trapp, Mollie Grow, Jared Tucker, Madeline Joseph, Lenna Liu, Ashley Weedn, Brooke Sweeney, Claudia Fox, Samreen Fathima, Ronald Williams, Roy Kim, William Stratbucker
BACKGROUND: Prospective patient registries have been successfully utilized in several disease states with a goal of improving treatment approaches through multi-institutional collaboration. The prevalence of youth with severe obesity is at a historic high in the United States, yet evidence to guide effective weight management is limited. The Pediatric Obesity Weight Evaluation Registry (POWER) was established in 2013 to identify and promote effective intervention strategies for pediatric obesity...
October 12, 2016: Childhood Obesity
https://www.readbyqxmd.com/read/27730346/stanniocalcin-1-enhances-carbon-flux-from-glucose-to-lipids-in-white-retroperitoneal-adipose-tissue-in-the-fed-rat
#19
Aline G Cozer, Márcia Trapp, Claudia Vieira Marques, Tiago L Martins, Jorge Felipe A Model, Vanessa Schein, Luiz Carlos Kucharski, Roselis S M Da Silva
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of (14)C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in (14)CO2 production from (14)C-glucose...
October 11, 2016: Lipids
https://www.readbyqxmd.com/read/27722184/the-physiological-role-of-the-brain-glp-1-system-in-stress
#20
Marie K Holt, Stefan Trapp
Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism's motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake...
December 31, 2016: Cogent Biology
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