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Stefan Trapp, Andreas Libonati Brock, Karolina Malgorzata Nowak, Matthias Kästner
Degradation tests with radio or stable isotope labeled compounds enable the detection of the formation of non-extractable residues (NER). In PBT and vPvB assessment, remobilisable NER are considered as a potential risk while biogenic NER from incorporation of labeled carbon into microbial biomass are treated as degradation products. Relationships between yield, released CO2 (as indicator of microbial activity and mineralization) and microbial growth can be used to estimate the formation of biogenic NER. We provide a new approach for calculation of potential substrate transformation to microbial biomass (theoretical yield) based on Gibbs free energy and microbially available electrons...
December 7, 2017: Environmental Science & Technology
Tatiane Grazieli Hammerschmidt, Graziela de Oliveira Schmitt Ribas, Maria Luiza Saraiva-Pereira, Márcia Polese Bonatto, Rejane Gus Kessler, Fernanda Timm Seabra Souza, Franciele Trapp, Kristiane Michelin-Tirelli, Maira Graeff Burin, Roberto Giugliani, Carmen Regla Vargas
BACKGROUND: Niemann-Pick type C (NP-C), one of 50 inherited lysosomal storage disorders, is caused by NPC protein impairment that leads to unesterified cholesterol accumulation in late endosomal/lysosomal compartments. The clinical manifestations of NP-C include hepatosplenomegaly, neurological and psychiatric symptoms. Current diagnosis for NP-C is based on observation of the accumulated cholesterol in fibroblasts of affected individuals, using an invasive and time expensive test, called Filipin staining...
November 29, 2017: International Journal of Developmental Neuroscience
Joan Gallardo-Donaire, Marko Hermsen, Jedrzej Wysocki, Martin Ernst, Frank Rominger, Oliver Trapp, A Stephen K Hashmi, Ansgar Schaefer, Peter Comba, Thomas Schaub
The asymmetric ruthenium-catalyzed reductive amination employ-ing ammonia and hydrogen to primary amines is described. Here we demonstrate the capability of our catalyst to perform a chemo- and enantioselective process while using simple ammonia gas as a reagent, one of the most attractive and industrially relevant nitrogen sources. The presence of a catalytic amount of ammonium iodide was essential for obtaining good yields and enantioselectivities. The mechanism of this reaction was investigated by DFT and we found a viable pathway that also explains the trend and magnitude of enantioselectivity through the halide series in good agreement with the experimental data...
December 1, 2017: Journal of the American Chemical Society
C E Pulker, G S A Trapp, J A Scott, C M Pollard
Supermarkets have been described as having unprecedented and disproportionate power in the food system. This scoping review synthesized the literature that describes the position and power of supermarkets in the Australian food system, and the implications for public health. A systematic search of peer-reviewed and grey literature identified 68 documents that described supermarket power. Implications for public health were also recorded. Data revealed that supermarkets hold a powerful position in the Australian food system, acting as the primary gatekeepers...
November 29, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Heiner Zimmermann, Timm Denecke, Martin H Dreyling, Christiane Franzius, Petra Reinke, Marion Subklewe, Holger Amthauer, Michael Kneba, Hanno Riess, Ralf U Trappe
BACKGROUND: Fluorine-18 fluorodeoxyglucose (18F-FDG) - positron-emission tomography (PET) is a recommended standard in the staging and response assessment of 18F-FDG-avid lymphoma. Posttransplant lymphoproliferative disorder (PTLD) can be detected by 18F-FDG-PET at diagnosis with high sensitivity and specificity. However, the role of response assessment by end of treatment (EOT)-PET has only been addressed in small case series. METHODS: We performed a retrospective, multi-center study of 37 patients with CD20-positive posttransplant lymphoproliferative disorder (PTLD) after solid organ transplantation (SOT) treated with uniform, up-to-date first-line protocols in the prospective German PTLD registry who had received EOT-18F-FDG-PET between 2006 and 2014...
November 17, 2017: Transplantation
Martin Christ, Katharina Isabel von Auenmüller, Michael Brand, Verena Gessner, Martin Grett, Nedall Zalloum, Wolfgang Dierschke, Hans-Joachim Trappe
Introduction The out-of-hospital cardiac-arrest (OHCA) is one of the leading causes of death. However, although previous studies showed the possibility to transplant organs from resuscitated donors, organ donation following OHCA remains seldom. We therefore initiated this study to investigate the current percentage of organ donation in victims of OHCA in a german university hospital. Material and Methods We analyzed data from all victims of OHCA who were admitted to our hospital between January 1st 2008 and May 31st 2017...
November 28, 2017: Deutsche Medizinische Wochenschrift
Nicolas Kerisit, Przemyslaw Gawel, Brian Levandowski, Yun-Fang Yang, Víctor García-López, Nils Trapp, Laurent Ruhlmann, Corinne Boudon, Kendall N Houk, François Diederich
A four-step synthesis of substituted 5,11-dicyano-6,12-diaryltetracenes was developed, starting from readily available para-substituted benzophenones. The key step of this straightforward route is the complex cascade reaction between tetraaryl[3]cumulenes and tetracyanoethene (TCNE) resulting in 5,5,11,11-tetracyano-5,11-dihydrotetracenes. The mechanism of this transformation was reinvestigated by means of theoretical calculations. The target tetracenes were obtained by a newly developed decyanation/aromatization reaction catalyzed by Cu(I) or Cu(II) complexes in solution, conditions compatible with a broad range of functional groups...
November 15, 2017: Chemistry: a European Journal
J Peters, J Marion, F J Becher, M Trapp, T Gutberlet, D J Bicout, T Heimburg
We compared the effect of cholesterol at different concentration on the phase behaviour of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) multilamellar vesicles. We used pressure perturbation differential scanning calorimetry (PPC) that studies a system on the whole by giving access to relevant thermodynamic quantities, and elastic incoherent neutron scattering (EINS) that probes local motions of a system at the atomic level by allowing extraction of dynamical parameters. PPC revealed that the volume expansion coefficient of DMPC and DMPC/Cholesterol samples with 13 and 25 mol% cholesterol is a linear function of the heat capacity measured by differential scanning calorimetry...
November 10, 2017: Scientific Reports
Marcin Skowron, Martin Trapp, Sabine Payr, Robert Trappl
We study the detection of character types from fictional dialog texts such as screenplays. As approaches based on the analysis of utterances' linguistic properties are not sufficient to identify all fictional character types, we develop an integrative approach that complements linguistic analysis with interactive and communication characteristics, and show that it can improve the identification performance. The interactive characteristics of fictional characters are captured by the descriptive analysis of semantic graphs weighted by linguistic markers of expressivity and social role...
November 25, 2016: Applied Artificial Intelligence: AAI
D Kesal, S Christau, M Trapp, P Krause, R von Klitzing
This work addresses the pH-triggered distribution and relocation of charge-stabilized gold nanoparticles (AuNPs) incorporated into strong polyelectrolyte brushes. Brush/particle composite materials were investigated under aqueous conditions and at different humidities using neutron and X-ray reflectivity, respectively. X-ray reflectivity measurements complement neutron reflectivity measurements and reveal results that could not be observed by neutron reflectivity measurements. Both methods allow scanning the particle density profile, but due to different contrasts, they are sensitive to different regions within the brush...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
Sabrina Trapp
No abstract text is available yet for this article.
2017: Frontiers in Neuroscience
Laura L Thomas, Aaron M N Joiner, J Christopher Fromme
Rab GTPases serve as molecular switches to regulate eukaryotic membrane trafficking pathways. The transport protein particle (TRAPP) complexes activate Rab GTPases by catalyzing GDP/GTP nucleotide exchange. In mammalian cells, there are two distinct TRAPP complexes, yet in budding yeast, four distinct TRAPP complexes have been reported. The apparent differences between the compositions of yeast and mammalian TRAPP complexes have prevented a clear understanding of the specific functions of TRAPP complexes in all cell types...
November 6, 2017: Journal of Cell Biology
Senne Braem, Sabrina Trapp
Recent studies suggest that humans prefer information that is linked to the process of prediction. Yet it remains to be specified whether preference judgments are biased to information that can be predicted, or information that enables to predict. We here use a serial reaction time task to disentangle these two options. In a first learning phase, participants were exposed to a continuous stream of arbitrary shapes while performing a go/no-go task. Embedded in this stream were hidden pairs of go-stimuli (e.g...
November 4, 2017: Psychological Research
Eve Laloy, Emmanuel Bréard, Sascha Trapp, Nathalie Pozzi, Mickaël Riou, Céline Barc, Sylvain Breton, Rémi Delaunay, Nathalie Cordonnier, Sophie Chateau-Joubert, Didier Crochet, Julie Gouzil, Typhaine Hébert, Maxime Raimbourg, Cyril Viarouge, Damien Vitour, Benoît Durand, Claire Ponsart, Stéphan Zientara
Schmallenberg virus (SBV) is an emerging virus responsible for congenital malformations in the offspring of domestic ruminants. It is speculated that infection of pregnant dams may also lead to a significant number of unrecognized fetal losses during the early period of gestation. To assess the pathogenic effects of SBV infection of goats in early pregnancy, we inoculated dams at day 28 or 42 of gestation and followed the animals until day 55 of gestation. Viremia in the absence of clinical signs was detected in all virus-inoculated goats...
November 2017: Veterinary Microbiology
A Marqueze, C F Garbino, M Trapp, L C Kucharski, M Fagundes, D Ferreira, G Koakoski, J G S Rosa
The fish may experience periods of food deprivation or starvation which produce metabolic changes. In this study, adult Rhamdia quelen males were subjected to fasting periods of 1, 7, 14, and 21 days and of refeeding 2, 4, 6, and 12 days. The results demonstrated that liver protein was depleted after 1 day of fasting, but recovered after 6 days of refeeding. After 14 days of fasting, mobilization in the lipids of the muscular tissue took place, and these reserves began to re-establish themselves after 4 days of refeeding...
October 30, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
Hermann H Klein, Udo Sechtem, Hans-Joachim Trappe
BACKGROUND: Medical students are taught little or nothing about the medical considerations related to the driving of motor vehicles. Physicians treating patients with cardiovascular disease need to acquire competence in traffic medicine in order to be able to advise them about their fitness to drive. METHODS: We present the current governmental regulations and recommendations concerning fitness to drive in patients with cardiovascular disease. We also review pertinent publications that were retrieved by a selective search in PubMed with the search terms "cardiovascular disease and traffic accidents" and "cardiovascular disease and traffic deaths" for the decade 2007-2016, as well as further publications collected by us individually...
October 13, 2017: Deutsches Ärzteblatt International
Diana Binny, Tanya Kairn, Craig M Lancaster, Jamie V Trapp, Scott B Crowe
This study aimed to provide guidance on the advantages and limitations of a new optimizer, "photon optimizer" (PO), when compared with its predecessor, "progressive resolution optimizer" (PRO), for intensity-modulated arc therapy (IMAT) plans. Eleven study plans that included a cohort of prostate, head and neck, and brain treatment sites were optimized using both PRO and PO algorithms. A plan template using the same objectives for the same number of iterations was used for each optimized plan to obtain hypothetical treatment plans that would be comparable with a clinical plan...
October 24, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Adrien Lion, Mathilde Richard, Evelyne Esnault, Emmanuel Kut, Denis Soubieux, Vanaïque Guillory, Mélody Germond, Caroline Blondeau, Rodrigo Guabiraba, Kirsty R Short, Daniel Marc, Pascale Quéré, Sascha Trapp
Endotheliotropism is a hallmark of gallinaceous poultry infections with highly pathogenic avian influenza (HPAI) viruses and a feature that distinguishes HPAI from low pathogenic avian influenza (LPAI) viruses. Here, we used chicken aortic endothelial cells (chAEC) as a novel in vitro infection model to assess the susceptibility, permissiveness, and host response of chicken endothelial cells (EC) to infections with avian influenza (AI) viruses. Our data show that productive replication of AI viruses in chAEC is critically determined by hemagglutinin cleavability, and is thus an exclusive trait of HPAI viruses...
October 11, 2017: Virology
Jacinta Francis, Karen Martin, Beth Costa, Hayley Christian, Simmi Kaur, Amelia Harray, Ann Barblett, Wendy Hazel Oddy, Gina Ambrosini, Karina Allen, Gina Trapp
OBJECTIVE: To determine young people's knowledge of energy drinks (EDs), factors influencing ED consumption, and intervention strategies to decrease ED consumption in young people. DESIGN: Eight group interviews with young people (aged 12-25 years). SETTING: Community groups and secondary schools in Perth, Western Australia. PARTICIPANTS: Forty-one young people, 41% of whom were male and 73% of whom consumed EDs. PHENOMENON OF INTEREST: Factors influencing ED consumption and intervention strategies informed by young people to reduce ED consumption...
October 2017: Journal of Nutrition Education and Behavior
Djihad Bencherit, Sylvie Remy, Yves Le Vern, Tereza Vychodil, Luca D Bertzbach, Benedikt B Kaufer, Caroline Denesvre, Laëtitia Trapp-Fragnet
Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that infects chickens and causes a deadly neoplastic disease. We previously demonstrated that MDV infection arrests cells in S-phase and that the tegument protein VP22 plays a major role in this process. In addition, expression of VP22 induces double strand breaks (DSB) in the cellular DNA, suggesting that DNA damage and the associated cellular response might be favorable for the MDV lifecycle. Here, we addressed the role of DNA damage in MDV replication and pathogenesis...
October 4, 2017: Journal of Virology
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