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https://www.readbyqxmd.com/read/28728194/-relevance-of-living-wills-during-post-resuscitation-care
#1
Martin Christ, Katharina Isabel von Auenmüller, Martin Grett, Scharbanu Amirie, Michael Brand, Hans-Joachim Trappe
Background There is hardly any evidence about the influence of living wills on acute life-threatening disease like out-of-hospital cardiac-arrest (OHCA). We therefore initiated this study to quantify the percentage of victims of OHCA who's living wills are available during post-resuscitation care. Methods All victims of OHCA who were admitted to our hospital between January 1(st) 2008 and July 31(th) 2016 were identified by analysis of our central admission register. Data from individual patients were collected from the patient's health records and anonymously stored on a central database...
July 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28721335/investigation-of-newborns-with-abnormal-results-in-a-newborn-screening-program-for-four-lysosomal-storage-diseases-in-brazil
#2
Heydy Bravo, Eurico Camargo Neto, Jaqueline Schulte, Jamile Pereira, Claudio Sampaio Filho, Fernanda Bittencourt, Fernanda Sebastião, Fernanda Bender, Ana Paula Scholz de Magalhães, Régis Guidobono, Franciele Barbosa Trapp, Kristiane Michelin-Tirelli, Carolina F M Souza, Diana Rojas Málaga, Gabriela Pasqualim, Ana Carolina Brusius-Facchin, Roberto Giugliani
Lysosomal storage diseases (LSDs) are genetic disorders, clinically heterogeneous, mainly caused by defects in genes encoding lysosomal enzymes that degrade macromolecules. Several LSDs already have specific therapies that may improve clinical outcomes, especially if introduced early in life. With this aim, screening methods have been established and newborn screening (NBS) for some LSDs has been developed. Such programs should include additional procedures for the confirmation (or not) of the cases that had an abnormal result in the initial screening...
September 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28706001/aspirin-as-a-cox-inhibitor-and-anti-inflammatory-drug-in-human-skeletal-muscle
#3
Steve M Ratchford, Kaleen M Lavin, Ryan K Perkins, Bozena Jemiolo, Scott W Trappe, Todd A Trappe
Although aspirin is one of the most common anti-inflammatory drugs in the world, the effect of aspirin on human skeletal muscle inflammation is almost completely unknown. This study examined the potential effects and related time course of an orally consumed aspirin dose on the inflammatory PGE2/COX pathway in human skeletal muscle. Skeletal muscle biopsies were taken from the vastus lateralis of 10 healthy adults (5M/5F, 25±2y) before and 2, 4, and 24h after consuming a standard dose of aspirin (975mg) and partitioned for analysis of 1) in vivo PGE2 levels in resting skeletal muscle and 2) ex vivo skeletal muscle PGE2 production when stimulated with the COX substrate arachidonic acid (5μM)...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28700115/lkb1-pro-oncogenic-activity-triggers-cell-survival-in-circulating-tumor-cells
#4
Elisabeth Katharina Trapp, Leonie Majunke, Beate Zill, Harald Sommer, Ulrich Andergassen, Julian Koch, Nadia Harbeck, Sven Mahner, Thomas Wolfram Paul Friedl, Wolfgang Janni, Brigitte Rack, Marianna Alunni-Fabbroni
During intravasation, circulating tumor cells (CTCs) detach from the epithelium of origin and begin the Epithelial-to Mesenchymal-Transition (EMT) process, where they lose epithelial features and pass through the endothelium to enter circulation. Although detachment from the extracellular matrix is a strong source of metabolic stress, which induces anoikis, CTCs can survive. Recently, the tumor suppressor liver kinase B1 (LKB1) has gained attention for its role as a proto-oncogene in restoring the correct ATP/AMP ratio during metabolic stress...
July 12, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28689411/adsorption-and-diffusion-of-c1-to-c4-alkanes-in-dual-porosity-zeolites-by-molecular-simulations
#5
Eliska Rezlerova, Arnost Zukal, Jiri Cejka, Flor R Siperstein, John Kennedy Brennan, Martin Lisal
We employ grand canonical Monte Carlo and molecular dynamics simulations to systematically study adsorption and diffusion of C1 to C4 alkanes in hierarchical ZSM-5 zeolite with micro- (~1nm) and mesopores (>2nm). The zeolite is characterized by a large surface area of active sites at the microporous scale with high permeability and access to the active sites, which arises from the enhanced transport at the mesoporous scale. We model this zeolite as a microporous Na+ exchanged alumino-sillicate zeolite ZSM-5/35 (Si/Al=35) in which cylindrical mesopores with diameter of 4nm have been built by deleting atoms accordingly...
July 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28687429/ecological-effects-of-scrubber-water-discharge-on-coastal-plankton-potential-synergistic-effects-of-contaminants-reduce-survival-and-feeding-of-the-copepod-acartia-tonsa
#6
Marja Koski, Colin Stedmon, Stefan Trapp
To meet the oncoming requirements for lower sulphur emissions, shipping companies can install scrubbers where the exhaust is sprayed with seawater and subsequently discharged to the sea. The discharge water has a pH around 3 and contains elevated concentrations of vanadium, nickel, lead and hydrocarbons. We investigated 1) the threshold concentrations of scrubber discharge water for survival, feeding and reproduction of the copepod Acartia tonsa, 2) whether the effects depend on the exposure route and 3) whether exposure to discharge water can be detected in field-collected organisms...
June 15, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28686941/diffusion-and-sorption-of-organic-micropollutants-in-biofilms-with-varying-thicknesses
#7
Elena Torresi, Fabio Polesel, Kai Bester, Magnus Christensson, Barth F Smets, Stefan Trapp, Henrik R Andersen, Benedek Gy Plósz
Solid-liquid partitioning is one of the main fate processes determining the removal of micropollutants in wastewater. Little is known on the sorption of micropollutants in biofilms, where molecular diffusion may significantly influence partitioning kinetics. In this study, the diffusion and the sorption of 23 micropollutants were investigated in novel moving bed biofilm reactor (MBBR) carriers with controlled biofilm thickness (50, 200 and 500 μm) using targeted batch experiments (initial concentration = 1 μg L(-1), for X-ray contrast media 15 μg L(-1)) and mathematical modelling...
June 14, 2017: Water Research
https://www.readbyqxmd.com/read/28682631/phase-diagram-of-methane-and-carbon-dioxide-hydrates-computed-by-monte-carlo-simulations
#8
Magnus Heskestad Waage, Thijs J H Vlugt, Signe Kjelstrup
Molecular Monte Carlo simulations are used to compute the three-phase (Hydrate-Liquid water-Gas) equilibrium lines of methane and carbon dioxide hydrates, using the TraPPE model for carbon dioxide, the OPLS-UA model for methane, and the TIP4P/Ice and TIP4P/2005 models for water. The three-phase equilibrium temperatures have been computed for pressures between 50 and 4000 bar via free energy calculations. The computed results behave as expected for methane hydrates, but deviates from direct coexistence Molecular Dynamics studies for carbon dioxide hydrates...
July 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28660412/-erratum-to-difficulties-with-children-of-abnormal-weight
#9
S Wirtz, C Eich, K Becke, S Brenner, A Callies, U Harding, C Höhne, F Hoffmann, J Kaufmann, B Landsleitner, H Marung, T Nicolai, F Reifferscheid, U Trappe, P Jung
No abstract text is available yet for this article.
June 28, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28639018/test-of-aerobic-tce-degradation-by-willows-salix-viminalis-and-willows-inoculated-with-tce-cometabolizing-strains-of-burkholderia-cepacia
#10
Lauge Peter Westergaard Clausen, Mette Martina Broholm, Ulrich Gosewinkel, Stefan Trapp
Trichloroethylene (TCE) is a widespread soil and groundwater pollutant and clean-up is often problematic and expensive. Phytoremediation may be a cost-effective solution at some sites. This study investigates TCE degradation by willows (S. viminalis) and willows inoculated with three strains of B. cepacia (301C, PR1-31 and VM1330-pTOM), using chloride formation as an indicator of dehalogenation. Willows were grown in non-sterile, hydroponic conditions for 3 weeks in chloride-free nutrient solution spiked with TCE...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634874/the-childcare-center-an-untapped-opportunity-to-engage-and-educate-families-in-healthy-behaviors
#11
Michelle M Cloutier, James F Wiley, Christine Trapp, Jennifer Haile, Amy A Gorin
Obesity rates in preschool children are high and disproportionately affect low-income children of color in the USA. Since 80% of preschool children spend ∼40 h/week in out-of-the home childcare, childcare centers are promising sites for obesity prevention interventions. Mixed methods were used to develop, implement, and assess the feasibility of an obesity prevention program for children 2-5 years. The intervention which consisted of brief (1-3 min), interactive, educational modules was developed by content experts and parents (n = 20) and targeted four areas (milk, sugar sweetened beverages, screen time, and physical activity)...
June 20, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28626029/a-homozygous-founder-mutation-in-trappc6b-associates-with-a-neurodevelopmental-disorder-characterised-by-microcephaly-epilepsy-and-autistic-features
#12
Isaac Marin-Valencia, Gaia Novarino, Anide Johansen, Basak Rosti, Mahmoud Y Issa, Damir Musaev, Gifty Bhat, Eric Scott, Jennifer L Silhavy, Valentina Stanley, Rasim O Rosti, Jeremy W Gleeson, Farhad B Imam, Maha S Zaki, Joseph G Gleeson
BACKGROUND: Transport protein particle (TRAPP) is a multisubunit complex that regulates membrane trafficking through the Golgi apparatus. The clinical phenotype associated with mutations in various TRAPP subunits has allowed elucidation of their functions in specific tissues. The role of some subunits in human disease, however, has not been fully established, and their functions remain uncertain. OBJECTIVE: We aimed to expand the range of neurodevelopmental disorders associated with mutations in TRAPP subunits by exome sequencing of consanguineous families...
June 16, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28624942/toxicity-of-56-substances-to-trees
#13
Lauge Peter Westergaard Clausen, Stefan Trapp
Toxicity data of substances to higher plants is needed for the purpose of risk assessment, site evaluation, phytoremediation, and plant protection. However, the results from the most common phytotoxicity tests, like the OECD algae and Lemna test, are not necessarily valid for higher terrestrial plants. The willow tree toxicity test uses inhibition of transpiration (aside of growth and water use efficiency) of willow cuttings grown in spiked solutions or soils as end point to quantify toxicity. This overview presents results from 60 studies including 24 new unpublished experiments for 56 different chemicals or substrates...
June 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28610691/radiological-properties-of-3d-printed-materials-in-kilovoltage-and-megavoltage-photon-beams
#14
O L Dancewicz, S R Sylvander, T S Markwell, S B Crowe, J V Trapp
PURPOSE: This study evaluates the radiological properties of different 3D printing materials for a range of photon energies, including kV and MV CT imaging and MV radiotherapy beams. METHODS: The CT values of a number of materials were measured on an Aquilion One CT scanner at 80kVp, 120kVp and a Tomotherapy Hi Art MVCT imaging beam. Attenuation of the materials in a 6MV radiotherapy beam was investigated. RESULTS: Plastic filaments printed with various infill densities have CT values of -743±4, -580±1 and -113±3 in 120kVp CT images which approximate the CT values of low-density lung, high-density lung and soft tissue respectively...
June 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28610690/investigating-output-and-energy-variations-and-their-relationship-to-delivery-qa-results-using-statistical-process-control-for-helical-tomotherapy
#15
Diana Binny, Emilio Mezzenga, Craig M Lancaster, Jamie V Trapp, Tanya Kairn, Scott B Crowe
The aims of this study were to investigate machine beam parameters using the TomoTherapy quality assurance (TQA) tool, establish a correlation to patient delivery quality assurance results and to evaluate the relationship between energy variations detected using different TQA modules. TQA daily measurement results from two treatment machines for periods of up to 4years were acquired. Analyses of beam quality, helical and static output variations were made. Variations from planned dose were also analysed using Statistical Process Control (SPC) technique and their relationship to output trends were studied...
June 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28570266/integrin-kindlin3-requirements-for-microglial-motility-in-vivo-are-distinct-from-those-for-macrophages
#16
Julia Meller, Zhihong Chen, Tejasvi Dudiki, Rebecca M Cull, Rakhilya Murtazina, Saswat K Bal, Elzbieta Pluskota, Samantha Stefl, Edward F Plow, Bruce D Trapp, Tatiana V Byzova
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a number of pathologies, understanding of the mechanisms of their migration in vivo is limited and often based on similarities to macrophages. Kindlin3 deficiency as well as Kindlin3 mutations of integrin-binding sites abolish both integrin inside-out and outside-in signaling in microglia, thereby resulting in severe deficiencies in cell adhesion, polarization, and migration in vitro, which are similar to the defects observed in macrophages...
June 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/28543597/special-issue-of-chirality-28-th-chirality-conference-iscd-28
#17
EDITORIAL
Oliver Trapp, Nina Berova, John Caldwell
No abstract text is available yet for this article.
May 23, 2017: Chirality
https://www.readbyqxmd.com/read/28536105/trappc13-modulates-autophagy-and-the-response-to-golgi-stress
#18
Silvia Ramírez-Peinado, Tatiana I Ignashkova, Bram J van Raam, Jan Baumann, Erica L Sennott, Mathieu Gendarme, Ralph K Lindemann, Michael N Starnbach, Jan H Reiling
Tether complexes play important roles in endocytic and exocytic trafficking of lipids and proteins. In yeast, the multisubunit transport protein particle (TRAPP) tether regulates endoplasmic reticulum (ER)-to-Golgi and intra-Golgi transport and is also implicated in autophagy. In addition, the TRAPP complex acts as a guanine nucleotide exchange factor (GEF) for Ypt1, which is homologous to human Rab1a and Rab1b. Here, we show that human TRAPPC13 and other TRAPP subunits are critically involved in the survival response to several Golgi-disrupting agents...
July 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28516907/vagal-determinants-of-exercise-capacity
#19
Asif Machhada, Stefan Trapp, Nephtali Marina, Robert C M Stephens, John Whittle, Mark F Lythgoe, Sergey Kasparov, Gareth L Ackland, Alexander V Gourine
Indirect measures of cardiac vagal activity are strongly associated with exercise capacity, yet a causal relationship has not been established. Here we show that in rats, genetic silencing of the largest population of brainstem vagal preganglionic neurons residing in the brainstem's dorsal vagal motor nucleus dramatically impairs exercise capacity, while optogenetic recruitment of the same neuronal population enhances cardiac contractility and prolongs exercise endurance. These data provide direct experimental evidence that parasympathetic vagal drive generated by a defined CNS circuit determines the ability to exercise...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28509359/the-dna-translocase-rad5a-acts-independently-of-the-other-main-dna-repair-pathways-and-requires-both-its-atpase-and-ring-domain-for-activity-in-arabidopsis-thaliana
#20
Tobias Klemm, Anja Mannuß, Daniela Kobbe, Alexander Knoll, Oliver Trapp, Annika Dorn, Holger Puchta
Multiple pathways exist to repair DNA damage induced by methylating and cross-linking agents in Arabidopsis thaliana. The SWI2/SNF2 translocase RAD5A, the functional homolog of budding yeast Rad5 that is required for the error-free branch of post replicative repair, plays a surprisingly prominent role in the repair of both kinds of lesions in Arabidopsis. Here we show that both the ATPase domain and the ubiquitination function of the RING domain of the Arabidopsis protein are essential for the cellular response to different forms of DNA damage...
May 16, 2017: Plant Journal: for Cell and Molecular Biology
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