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Nathen A Spitz, Benjamin D Pace, Patrick Ten Eyck, Nicholas T Trapp
[This corrects the article DOI: 10.3389/fpsyt.2022.863225.].
2024: Frontiers in Psychiatry
#2
JOURNAL ARTICLE
Hans-Joachim Trappe
BACKGROUND: Gustav Mahler was a composer of the late Romantic period, one of the most famous conductors of his time and, as opera director, one of the most important reformers of musical theatre. Mahler's life, illnesses, death and dying are little or not at all known to many. OBJECTIVES: Which illnesses determined Mahler's life? Could his early death have been avoided? From today's point of view, could modern intensive care medicine have helped him? MATERIAL AND METHODS: A detailed analysis of Mahler's diseases was performed using scientific databases (medline, pubmed)...
April 18, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
#3
Mucen Yu, Jielin Xu, Ranjan Dutta, Bruce Trapp, Andrew A Pieper, Feixiong Cheng
Amyotrophic Lateral Sclerosis (ALS) is a devastating, immensely complex neurodegenerative disease by lack of effective treatments. To date, the challenge to establishing effective treatment for ALS remains formidable, partly due to inadequate translation of existing human genetic findings into actionable ALS-specific pathobiology for subsequent therapeutic development. This study evaluates the feasibility of network medicine methodology via integrating human brain-specific multi-omics data to prioritize drug targets and repurposable treatments for ALS...
March 30, 2024: bioRxiv
#4
REVIEW
Jorge Román Corona-Rivera, Iván Martínez-Duncker, Eva Morava, Wasantha Ranatunga, Roberta Salinas-Marin, Ana María González-Jaimes, Katia Alejandra Castillo-Reyes, Christian Peña-Padilla, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Mireya Orozco-Vela, Sinhue Alejandro Brukman-Jiménez
The trafficking protein particle (TRAPP) complex is a multisubunit protein complex that functions as a tethering factor involved in intracellular trafficking. TRAPPC11, a crucial subunit of this complex, is associated with pathogenic variants that cause a spectrum of disease, which can range from a limb girdle muscular dystrophy (LGMD) to developmental disability with muscle disease, movement disorder and global developmental delay (GDD)/intellectual disability (ID), or even a congenital muscular dystrophy (CMD)...
March 28, 2024: Molecular Genetics and Metabolism
#5
JOURNAL ARTICLE
Dong-Nyeong Lee, Seong-Bin Yang, Seho Kweon, Jun-Hyuck Lee, Kyeong-Ju Lee, Yeonsu Ryu, Dong Wook Shin, Young Jun Kim, Yong-Kyu Lee, Jooho Park
Catechol-based biomaterials demonstrate biocompatibility, making them suitable for a wide range of therapeutic applications when integrated into various molecular frameworks. However, the development of orally available catechol-based biomaterials has been hindered by significant pH variations and complex interactions in the gastrointestinal (GI) tract. In this study, we introduce a novel catechol-modified bile acid (CMBA), which is synthesized by anchoring the FDA-approved drug, ursodeoxycholic acid to the neurotransmitter dopamine...
March 24, 2024: Biomaterials
#6
JOURNAL ARTICLE
Mirella Luciani, Gisella Armillotta, Tiziana Di Febo, Ivanka Krasteva, Simonetta Ulisse, Chiara Di Pancrazio, Caterina Laguardia, Fabrizia Perletta, Anna Serroni, Marta Maggetti, Lilia Testa, Flavio Sacchini, Mariangela Iorio, Diamante Rodomonti, Manuela Tittarelli, Maria Teresa Mercante
The significance of Trypanosoma equiperdum as the causative agent of dourine cannot be understated, especially given its high mortality rate among equids. International movement of equids should be subject to thorough health checks and screenings to ensure that animals are not infected with Trypanosoma equiperdum . This involves the implementation of quarantine protocols, testing procedures, and the issuance of health certificates to certify the health status of the animals. Three proteins, the peptidyl-prolyl cis-trans isomerase (A0A1G4I8N3), the GrpE protein homolog (A0A1G4I464) and the transport protein particle (TRAPP) component, putative (A0A1G4I740) (UniProt accession numbers SCU68469...
March 13, 2024: Veterinary Sciences
#7
JOURNAL ARTICLE
Yorran Hardman Araújo Montenegro, Francyne Kubaski, Franciele Barbosa Trapp, Mariluce Riegel-Giugliani, Carolina Fischinger Moura de Souza, Erlane Marques Ribeiro, Charles Marques Lourenço, Augusto César Cardoso-Dos-Santos, Márcia Gonçalves Ribeiro, Chong Ae Kim, Matheus Augusto Araújo Castro, Emília Katiane Embiruçu, Carlos Eduardo Steiner, Filippo Pinto E Vairo, Guilherme Baldo, Roberto Giugliani, Fabiano de Oliveira Poswar
Mucopolysaccharidosis type IIIB (MPS IIIB) is caused by deficiency of alpha-N-acetylglucosaminidase, leading to storage of heparan sulphate. The disease is characterized by intellectual disability and hyperactivity, among other neurological and somatic features. Here we studied retrospective data from a total of 19 MPS IIIB patients from Brazil, aiming to evaluate disease progression. Mean age at diagnosis was 7.2 years. Speech delay was one of the first symptoms to be identified, around 2-3 years of age. Behavioral alterations include hyperactivity and aggressiveness, starting around age four...
2024: Genetics and Molecular Biology
#8
JOURNAL ARTICLE
Linh T Tran, Caner Akıl, Yosuke Senju, Robert C Robinson
Membrane-enclosed organelles are defining features of eukaryotes in distinguishing these organisms from prokaryotes. Specification of distinct membranes is critical to assemble and maintain discrete compartments. Small GTPases and their regulators are the signaling molecules that drive membrane-modifying machineries to the desired location. These signaling molecules include Rab and Rag GTPases, roadblock and longin domain proteins, and TRAPPC3-like proteins. Here, we take a structural approach to assess the relatedness of these eukaryotic-like proteins in Asgard archaea, the closest known prokaryotic relatives to eukaryotes...
March 12, 2024: Communications Biology
#9
REVIEW
Renee N Carey, Gemma Crawford, Jonine Jancey, Tina Lam, Lauren Nimmo, Gina Trapp, Christina Pollard, Paula Hooper, Justine E Leavy
ISSUES: The surrounding social and commercial context, including alcohol advertising, heavily influences alcohol consumption. Alcohol use is a major risk factor for both fatal and non-fatal drowning, particularly for young people. APPROACH: We conducted a scoping review to explore the peer-reviewed literature on the use of alcohol by young people (aged 15-34 years) in the context of aquatic environments. Five electronic academic databases were searched for English-language studies conducted in high-income countries and published in the last 15 years (since 2008)...
March 10, 2024: Drug and Alcohol Review
#10
JOURNAL ARTICLE
Sophia Scharl, Constantinos Zamboglou, Iosif Strouthos, Andrea Farolfi, Francesca Serani, Stefan A Koerber, Jürgen Debus, Jan C Peeken, Marco M E Vogel, Stephanie G C Kroeze, Matthias Guckenberger, Manuel Krafcsik, George Hruby, Louise Emmett, Nina-Sophie Schmidt-Hegemann, Christian Trapp, Simon K B Spohn, Christoph Henkenberens, Benjamin Mayer, Mohamed Shelan, Daniel M Aebersold, Reinhard Thamm, Thomas Wiegel
PURPOSE: The European Association of Urology (EAU) proposed a risk stratification (high vs. low risk) for patients with biochemical recurrence (BR) following radical prostatectomy (RP). Here we investigated whether this stratification accurately predicts outcome, particularly in patients staged with PSMA-PET. METHODS: For this study, we used a retrospective database including 1222 PSMA-PET-staged prostate cancer patients who were treated with salvage radiotherapy (SRT) for BR, at 11 centers in 5 countries...
March 6, 2024: Radiotherapy and Oncology
#11
REVIEW
Helmut U Klein, Hans-Joachim Trappe, Günter Frank
Direct current (DC) catheter ablation in 5 patients aiming to interrupt rapid atrioventricular (AV) conduction with atrial fibrillation and subsequent pacemaker implantation was first published by M. M. Scheinman et al. (San Francisco, CA, USA) in 1982. In Germany, L. Seipel, G. Breithardt, and M. Borggrefe reported their first experience with DC catheter ablation in 1984, followed by the group in Bonn (M. Manz and B. Lüderitz) in 1985. The first international DC catheter ablation registry, which also included four German centers, reported DC catheter ablation results of 127 patients in 24 centers in 1984...
February 29, 2024: Herzschrittmachertherapie & Elektrophysiologie
#12
EDITORIAL
Oliver Trapp, Nina Berova, Simona Collina, Gennaro Pescitelli
No abstract text is available yet for this article.
March 2024: Chirality
#13
REVIEW
Helmut U Klein, Hans-Joachim Trappe, Günter Frank
The history of surgical treatment of ventricular tachycardias (VT) is short, lasting from 1978 until 1993. "Indirect procedures" with infarct scar resection were performed without electrophysiologic studies, whereas "direct procedures" consisted of either complete endocardial incisions ("encircling endocardial ventriculotomy") or large endocardial resections ("endocardial peel-off" technique) after precise epicardial and endocardial mapping procedures. In Germany, the first to report on intra-operative electrophysiologic mapping for VT treatment were Ostermeyer, Breithardt and Seipel in 1979...
February 28, 2024: Herzschrittmachertherapie & Elektrophysiologie
#14
JOURNAL ARTICLE
Hans-Joachim Trappe, Eva-Maria Völkel, Gerald Reiner
BACKGROUND: The importance of music in intensive care medicine is still controversial and the mechanisms of music are unclear. It is important whether different music styles (classical music [CM], Heavy Metal [HM] show measurable effects on blood pressure (BP) or heart rate (HR) in humans or not. It is also unclear whether behavioral patterns are influenced by music (CM, HM) in animals. METHODS: We studied the influence of CM (Bach, Orchestral Suite No. 3, BWV 1068) and HM (Band Disturbed: Indestructible) compared to a control group (CO) without music exposure in 120 healthy subjects (60 study subjects, 60 control subjects) and 36 young pigs (18 Pietrains, 18 Wiesenauer Minipigs) according to an identical study protocol (21 minutes of music exposure (CM, HM) or 21 minutes of no music (C0)...
February 22, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
#15
JOURNAL ARTICLE
Anthony Chomyk, Rikki Kucinski, Jihye Kim, Emilie Christie, Kaitlyn Cyncynatus, Zachary Gossman, Zhihong Chen, Brian Richardson, Mark Cameron, Tim Turner, Ranjan Dutta, Bruce Trapp
OBJECTIVE: Microglia/macrophages line the border of demyelinated lesions in both cerebral white matter and the cortex in the brains of multiple sclerosis patients. Microglia/macrophages associated with chronic white matter lesions are thought to be responsible for slow lesion expansion and disability progression in progressive multiple sclerosis, whereas those lining gray matter lesions are less studied. Profiling these microglia/macrophages could help to focus therapies on genes or pathways specific to lesion expansion and disease progression...
February 12, 2024: Annals of Neurology
#16
JOURNAL ARTICLE
Todd A Trappe, Kiril Minchev, Ryan K Perkins, Kaleen M Lavin, Bozena Jemiolo, Stephen M Ratchford, Alex Claiborne, Gary A Lee, W Holmes Finch, Jeffrey W Ryder, Lori Ploutz-Snyder, Scott W Trappe
The efficacy of the NASA SPRINT exercise countermeasures program for quadriceps (vastus lateralis) and triceps surae (soleus) skeletal muscle health was investigated during 70 days of simulated microgravity. Individuals completed 6° head-down-tilt bedrest (BR, n=9), bedrest with resistance and aerobic exercise (BRE, n=9), or bedrest with resistance and aerobic exercise and low-dose testosterone (BRE+T, n=8). All groups were periodically tested for muscle (n=9 times) and aerobic (n=4 times) power during bedrest...
February 8, 2024: Journal of Applied Physiology
#17
JOURNAL ARTICLE
Jeffrey B Wang, Umair Hassan, Joel E Bruss, Hiroyuki Oya, Brandt D Uitermarkt, Nicholas T Trapp, Phillip E Gander, Matthew A Howard, Corey J Keller, Aaron D Boes
Transcranial magnetic stimulation (TMS) is increasingly used as a noninvasive technique for neuromodulation in research and clinical applications, yet its mechanisms are not well understood. Here, we present the neurophysiological effects of TMS using intracranial electrocorticography (iEEG) in neurosurgical patients. We first evaluated safety in a gel-based phantom. We then performed TMS-iEEG in 22 neurosurgical participants with no adverse events. We next evaluated intracranial responses to single pulses of TMS to the dorsolateral prefrontal cortex (dlPFC) (N = 10, 1414 electrodes)...
February 5, 2024: Molecular Psychiatry
#18
JOURNAL ARTICLE
Margaret L Antonio, Clemens L Weiß, Ziyue Gao, Susanna Sawyer, Victoria Oberreiter, Hannah M Moots, Jeffrey P Spence, Olivia Cheronet, Brina Zagorc, Elisa Praxmarer, Kadir Toykan Özdoğan, Lea Demetz, Pere Gelabert, Daniel Fernandes, Michaela Lucci, Timka Alihodžić, Selma Amrani, Pavel Avetisyan, Christèle Baillif-Ducros, Željka Bedić, Audrey Bertrand, Maja Bilić, Luca Bondioli, Paulina Borówka, Emmanuel Botte, Josip Burmaz, Domagoj Bužanić, Francesca Candilio, Mirna Cvetko, Daniela De Angelis, Ivan Drnić, Kristián Elschek, Mounir Fantar, Andrej Gaspari, Gabriella Gasperetti, Francesco Genchi, Snežana Golubović, Zuzana Hukeľová, Rimantas Jankauskas, Kristina Jelinčić Vučković, Gordana Jeremić, Iva Kaić, Kevin Kazek, Hamazasp Khachatryan, Anahit Khudaverdyan, Sylvia Kirchengast, Miomir Korać, Valérie Kozlowski, Mária Krošláková, Dora Kušan Špalj, Francesco La Pastina, Marie Laguardia, Sandra Legrand, Tino Leleković, Tamara Leskovar, Wiesław Lorkiewicz, Dženi Los, Ana Maria Silva, Rene Masaryk, Vinka Matijević, Yahia Mehdi Seddik Cherifi, Nicolas Meyer, Ilija Mikić, Nataša Miladinović-Radmilović, Branka Milošević Zakić, Lina Nacouzi, Magdalena Natuniewicz-Sekuła, Alessia Nava, Christine Neugebauer-Maresch, Jan Nováček, Anna Osterholtz, Julianne Paige, Lujana Paraman, Dominique Pieri, Karol Pieta, Stefan Pop-Lazić, Matej Ruttkay, Mirjana Sanader, Arkadiusz Sołtysiak, Alessandra Sperduti, Tijana Stankovic Pesterac, Maria Teschler-Nicola, Iwona Teul, Domagoj Tončinić, Julien Trapp, Dragana Vulović, Tomasz Waliszewski, Diethard Walter, Miloš Živanović, Mohamed El Mostefa Filah, Morana Čaušević-Bully, Mario Šlaus, Dušan Borić, Mario Novak, Alfredo Coppa, Ron Pinhasi, Jonathan K Pritchard
Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000-3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e...
January 30, 2024: ELife
#19
JOURNAL ARTICLE
Francesca Bagnato, Pascal Sati, Christopher C Hemond, Colm Elliott, Susan A Gauthier, Daniel M Harrison, Caterina Mainero, Jiwon Oh, David Pitt, Russell T Shinohara, Seth A Smith, Bruce Trapp, Christina J Azevedo, Peter A Calabresi, Roland G Henry, Cornelia Laule, Daniel Ontaneda, William D Rooney, Nancy L Sicotte, Daniel S Reich, Martina Absinta
Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis (MS) and have implications for non-relapsing biological progression. In recent years, the discovery of innovative magnetic resonance imaging (MRI) and PET derived biomarkers has made it possible to detect CAL, and to some extent quantify them, in the brain of persons with MS, in vivo. Paramagnetic rim lesions on susceptibility-sensitive MRI sequences, MRI-defined slowly expanding lesions on T1-weighted (T1-w) and T2-w scans, and 18-kDa translocator protein-positive lesions on PET are promising candidate biomarkers of CAL...
January 16, 2024: Brain
#20
JOURNAL ARTICLE
Colleen E Lynch, Anna R Brandt, Caroline S Vincenty, Ethan Robbins, Chad Skiles, Kiril Minchev, Toby L Chambers, Alicia Belangee, Todd A Trappe, Scott W Trappe
Adipose biopsy techniques are relatively undefined for exercise physiology research in individuals at or near normal weight. The purpose of this study was to compare the influence of two adipose biopsy techniques on tissue quality through measurements of adipocyte cell size, as well as mRNA and protein levels of select pro- and anti-inflammatory cytokines and adipokines. Thirteen participants (9M, 4W; 28±4 y; 27±3 kg•m-2 ; VO2 max: 3.3±0.7 L•min-1 ) underwent subcutaneous adipose biopsies on either side of the umbilicus (incision: ~8 cm lateral, sampling area: ~5 cm lateral) using 1) a 6 mm Bergström biopsy needle and 2) a mini-liposuction approach with a 4 mm Mercedes biopsy needle that employed pre-biopsy tumescent delivery (~30 mL 0...
January 15, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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