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https://www.readbyqxmd.com/read/29031164/productive-replication-of-avian-influenza-viruses-in-chicken-endothelial-cells-is-determined-by-hemagglutinin-cleavability-and-is-related-to-innate-immune-escape
#1
Adrien Lion, Mathilde Richard, Evelyne Esnault, Emmanuel Kut, Denis Soubieux, Vanaïque Guillory, Mélody Germond, Caroline Blondeau, Rodrigo Guabiraba, Kirsty R Short, Daniel Marc, Pascale Quéré, Sascha Trapp
Endotheliotropism is a hallmark of gallinaceous poultry infections with highly pathogenic avian influenza (HPAI) viruses and a feature that distinguishes HPAI from low pathogenic avian influenza (LPAI) viruses. Here, we used chicken aortic endothelial cells (chAEC) as a novel in vitro infection model to assess the susceptibility, permissiveness, and host response of chicken endothelial cells (EC) to infections with avian influenza (AI) viruses. Our data show that productive replication of AI viruses in chAEC is critically determined by hemagglutinin cleavability, and is thus an exclusive trait of HPAI viruses...
October 11, 2017: Virology
https://www.readbyqxmd.com/read/28987203/informing-intervention-strategies-to-reduce-energy-drink-consumption-in-young-people-findings-from-qualitative-research
#2
Jacinta Francis, Karen Martin, Beth Costa, Hayley Christian, Simmi Kaur, Amelia Harray, Ann Barblett, Wendy Hazel Oddy, Gina Ambrosini, Karina Allen, Gina Trapp
OBJECTIVE: To determine young people's knowledge of energy drinks (EDs), factors influencing ED consumption, and intervention strategies to decrease ED consumption in young people. DESIGN: Eight group interviews with young people (aged 12-25 years). SETTING: Community groups and secondary schools in Perth, Western Australia. PARTICIPANTS: Forty-one young people, 41% of whom were male and 73% of whom consumed EDs. PHENOMENON OF INTEREST: Factors influencing ED consumption and intervention strategies informed by young people to reduce ED consumption...
October 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28978699/induction-of-dna-damages-upon-marek-s-disease-virus-infection-implication-in-viral-replication-and-pathogenesis
#3
Djihad Bencherit, Sylvie Remy, Yves Le Vern, Tereza Vychodil, Luca D Bertzbach, Benedikt B Kaufer, Caroline Denesvre, Laëtitia Trapp-Fragnet
Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that infects chickens and causes a deadly neoplastic disease. We previously demonstrated that MDV infection arrests cells in S-phase and that the tegument protein VP22 plays a major role in this process. In addition, expression of VP22 induces double strand breaks (DSB) in the cellular DNA, suggesting that DNA damage and the associated cellular response might be favorable for the MDV lifecycle. Here, we addressed the role of DNA damage in MDV replication and pathogenesis...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28967982/conformational-aspects-in-the-design-of-inhibitors-for-serine-hydroxymethyltransferase-shmt-biphenyl-aryl-sulfonamide-and-aryl-sulfone-motifs
#4
Geoffrey Schwertz, Michelle S Frei, Matthias C Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A Aponte, Nils Trapp, Kerstin Mark, Pimchai Chaiyen, François Diederich
Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were synthesized and tested towards serine hydroxymethyltransferase (SHMT), a key enzyme of the folate cycle. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target, as well as PfNF54 strains in cell-based assays in the low nanomolar range (18-56 nm)...
October 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28955625/characterization-of-natural-habitats-and-diversity-of-libyan-desert-truffles
#5
Mozidi Bouzadi, Tine Grebenc, Ossi Turunen, Hojka Kraigher, Hassan Taib, Abdulhafied Alafai, Imed Sbissi, Mamdouh El Haj Assad, Dattatray Bedade, Salem Shamekh
Desert truffles have traditionally been used as food in Libya. Desert truffle grows and gives fruit sporadically when adequate and properly distributed rainfall occurs with existence of suitable soil and mycorrhizal host plant. The present study aimed to identify and characterize two kinds of wild desert truffles from ecological and nutritional points that were collected from the studied area. The truffle samples were identified as Terfezia (known as red or black truffle) and Tirmania (known as white truffle)...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28946593/symbol-digit-modalities-test-normative-data-for-spanish-speaking-pediatric-population
#6
J C Arango-Lasprilla, D Rivera, Stephen Trapp, C Jiménez-Pérez, C L Hernández Carrillo, S Pohlenz Amador, E Vergara-Moragues, Y Rodríguez-Agudelo, W Rodriguez-Irizarry, C García de la Cadena, A Galvao-Carmona, J Galarza-Del-Angel, X Llerena Espezúa, N Torales Cabrera, P F Caravia, A Aguayo Arelis, M Saracostti Schwartzman, R Barranco Casimiro, N Albaladejo-Blázquez
OBJECTIVE: To generate normative data for the Symbol Digit Modalities Test (SDMT) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru and Puerto Rico) and Spain. Each participant was administered the SDMT as part of a larger neuropsychological battery. SDMT scores were normed using multiple linear regressions and standard deviations of residual values...
September 16, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28945881/allogeneic-hematopoietic-cell-transplantation-in-intermediate-risk-acute-myeloid-leukemia-negative-for-flt3-itd-npm1-or-biallelic-cebpa-mutations
#7
K Heidrich, C Thiede, K Schäfer-Eckart, N Schmitz, W E Aulitzky, A Krämer, W Rösler, M Hänel, H Einsele, C D Baldus, R U Trappe, F Stölzel, J M Middeke, C Röllig, F Taube, M Kramer, H Serve, W E Berdel, G Ehninger, M Bornhäuser, J Schetelig
Background: The value of allogeneic hematopoietic cell transplantation (alloHCT) as post-remission treatment is not well defined for patients with intermediate-risk acute myeloid leukemia (AML) without FLT3 -ITD, biallelic CEBPA -, or NPM1 mutations (here referred to as NPM1 mut-neg / CEBPA dm-neg / FLT3 -ITD neg AML) in first complete remission (CR1). Patients and methods: We addressed this question using data from two prospective randomized controlled trials on intensive induction- and risk-stratified post-remission therapy The NPM1 mut-neg / CEBPA dm-neg / FLT3 -ITD neg AML subgroup comprised 497 patients, aged 18-60 years...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28922527/helical-threads-enantiomerically-pure-carbo-6-helicene-oligomers
#8
Cédric Schaack, Eric Sidler, Nils Trapp, François Diederich
We report the synthesis of enantiomerically pure carbo[6]helicene oligomers with buta-1,3-diyne-1,4-diyl bridges between the helicene nuclei. The synthesis of monomeric (±)-2,15-bis[(triisopropylsilyl)ethynyl]carbo[6]helicene was achieved in 25 % yield over six steps. Pure (+)-(P)- and (-)-(M)-enantiomers were obtained by HPLC on a chiral stationary phase. The dimeric (+)-(P)2 - and (-)-(M)2 -configured and the tetrameric (+)-(P)4 - and (-)-(M)4 -configured oligomers were obtained by sequential oxidative acetylenic coupling...
October 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28920669/in-situ-studies-of-solid-electrolyte-interphase-sei-formation-on-crystalline-carbon-surfaces-by-neutron-reflectometry-and-atomic-force-microscopy
#9
Miriam Steinhauer, Michael Stich, Mario Kurniawan, Beatrix-Kamelia Seidlhofer, Marcus Trapp, Andreas Bund, Norbert Wagner, K Andreas Friedrich
The solid electrolyte interphase (SEI) is a complex and fragile passivation layer with crucial importance for the functionality of lithium-ion batteries. Due to its fragility and reactivity, the use of in situ techniques is preferable for the determination of the SEI's true structure and morphology during its formation. In this study, we use in situ neutron reflectometry (NR) and in situ atomic force microscopy (AFM) to investigate the SEI formation on a carbon surface. It was found that a lithium-rich adsorption layer is already present at the open circuit voltage on the carbon sample surface and that the first decomposition products start to deposit close to this potential...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28893109/microbial-growth-yield-estimates-from-thermodynamics-and-its-importance-for-degradation-of-pesticides-and-formation-of-biogenic-non-extractable-residues
#10
A L Brock, M Kästner, S Trapp
In biodegradation studies with isotope-labelled pesticides, fractions of non-extractable residues (NER) remain, but their nature and composition is rarely known, leading to uncertainty about their risk. Microbial growth leads to incorporation of carbon into the microbial mass, resulting in biogenic NER. Formation of microbial mass can be estimated from the microbial growth yield, but experimental data is rare. Instead, we suggest using prediction methods for the theoretical yield based on thermodynamics. Recently, we presented the Microbial Turnover to Biomass (MTB) method that needs a minimum of input data...
September 12, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28885190/film-dosimetry-using-a-smart-device-camera-a-feasibility-study-for-point-dose-measurements
#11
Trent Aland, Ekta Jhala, Tanya Kairn, Jamie V Trapp
In this work, a methodology for using a smartphone camera, in conjunction with a light-tight box operating in reflective transmission mode, is investigated as a proof of concept for use as a film dosimetry system. An imaging system was designed to allow the camera of a smartphone to be used as a pseudo densitometer. Ten pieces of Gafchromic EBT3 film were irradiated to doses up to 16.89 Gy and used to evaluate the effects of reproducibility and orientation, as well as the ability to create an accurate dose response curve for the smartphone based dosimetry system, using all three colour channels...
September 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28855776/the-value-of-arterial-blood-gas-parameters-for-prediction-of-mortality-in-survivors-of-out-of-hospital-cardiac-arrest
#12
Katharina Isabel von Auenmueller, Martin Christ, Benjamin Michel Sasko, Hans-Joachim Trappe
CONTEXT: Sudden cardiac death is one of the leading causes of death in Europe, and early prognostication remains challenging. There is a lack of valid parameters for the prediction of survival after cardiac arrest. AIMS: This study aims to investigate if arterial blood gas parameters correlate with mortality of patients after out-of-hospital cardiac arrest. MATERIALS AND METHODS: All patients who were admitted to our hospital after resuscitation following out-of-hospital cardiac arrest between January 1, 2008, and December 31, 2013, were included in this retrospective study...
July 2017: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/28833377/t1-t2-weighted-ratio-differs-in-demyelinated-cortex-in-multiple-sclerosis
#13
Kunio Nakamura, Jacqueline T Chen, Daniel Ontaneda, Robert J Fox, Bruce D Trapp
Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted (T1w) and T2-weighted (T2w) images may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from 6 cadavers with MS on a 3T MRI machine. Immunocytochemistry was used to correlate myelin status and cortical T1w/T2w measures. The results showed that the T1w/T2w values significantly differed between demyelinated and myelinated cortex (p < 0...
August 18, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28830171/electrostatic-and-induction-effects-in-the-solubility-of-water-in-alkanes
#14
D Asthagiri, Arjun Valiya Parambathu, Deepti Ballal, Walter G Chapman
Experiments show that at 298 K and 1 atm pressure, the transfer free energy, μ(ex), of water from its vapor to liquid normal alkanes CnH2n+2 (n=5…12) is negative. Earlier it was found that with the united-atom TraPPE model for alkanes and the SPC/E model for water, one had to artificially enhance the attractive alkane-water cross interaction to capture this behavior. Here we revisit the calculation of μ(ex) using the polarizable AMOEBA and the non-polarizable Charmm General (CGenFF) forcefields. We test both the AMOEBA03 and AMOEBA14 water models; the former has been validated with the AMOEBA alkane model while the latter is a revision of AMOEBA03 to better describe liquid water...
August 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28821749/dna-methylation-in-demyelinated-multiple-sclerosis-hippocampus
#15
Anthony M Chomyk, Christina Volsko, Ajai Tripathi, Sadie A Deckard, Bruce D Trapp, Robert J Fox, Ranjan Dutta
Multiple Sclerosis (MS) is an immune-mediated demyelinating disease of the human central nervous system (CNS). Memory impairments and hippocampal demyelination are common features in MS patients. Our previous data have shown that demyelination alters neuronal gene expression in the hippocampus. DNA methylation is a common epigenetic modifier of gene expression. In this study, we investigated whether DNA methylation is altered in MS hippocampus following demyelination. Our results show that mRNA levels of DNA methyltransferase were increased in demyelinated MS hippocampus, while de-methylation enzymes were decreased...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820941/a-photoactivatable-probe-for-super-resolution-imaging-of-enzymatic-activity-in-live-cells
#16
Elias A Halabi, Zacharias Thiel, Nils Trapp, Dorothea Pinotsi, Pablo Rivera-Fuentes
A dual-activatable, fluorogenic probe was developed to sense esterase activity with single-molecule resolution. Without enzymatic pre-activation, the diazoindanone-based probe has an electron-poor core and, upon irradiation, undergoes Wolff rearrangement to give a ring-expanded xanthene core that is nonemissive. If the probe is pre-activated by carboxylesterases, the tricyclic core becomes electron-rich, and the photoinduced Wolff rearrangement produces a highly emissive rhodol dye. Live-cell and solution studies confirmed the selectivity of the probe and revealed that the photoactivated dye does not diffuse away from the original location of activation because the intermediate ketene forms a covalent bond with surrounding macromolecules...
September 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28809485/dispersion-and-halogen-bonding-interactions-binding-of-the-axial-conformers-of-monohalo-and-%C3%A2-trans-1-2-dihalocyclohexanes-in-enantiopure-alleno-acetylenic-cages
#17
Cornelius Gropp, Tamara Husch, Nils Trapp, Markus Reiher, François Diederich
Enantiopure alleno-acetylenic cage (AAC) receptors with a resorcin[4]arene scaffold, from which four homochiral alleno-acetylenes converge to shape a cavity closed by a four-fold OH-hydrogen-bonding array, form a highly ordered porous network in the solid state. They enable the complexation and co-crystallization of otherwise non-crystalline small molecules. This paper analyzes the axial conformers of monohalo- and (±)-trans-1,2-dihalocyclohexanes, bound in the interior cavity of the AACs, on the atomic level in the solid state and in solution, accompanied by accurate calculations...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28792215/thermodynamic-and-transport-properties-of-crown-ethers-force-field-development-and-molecular-simulations
#18
Seyed Hossein Jamali, Mahinder Ramdin, Tim M Becker, Shwet Kumar Rinwa, Wim Buijs, Thijs J H Vlugt
Crown-ethers have recently been used to assemble porous liquids (PLs), which are liquids with permanent porosity formed by mixing bulky solvent molecules (e.g., 15-crown-5 ether) with solvent-inaccessible organic cages. PLs and crown-ethers belong to a novel class of materials, which can potentially be used for gas separation and storage, but their performance for this purpose needs to be assessed thoroughly. Here, we use molecular simulations to study the gas separation performance of crown-ethers as the solvent of porous liquids...
September 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28777934/mutations-in-trappc12-manifest-in-progressive-childhood-encephalopathy-and-golgi-dysfunction
#19
Miroslav P Milev, Megan E Grout, Djenann Saint-Dic, Yong-Han Hank Cheng, Ian A Glass, Christopher J Hale, David S Hanna, Michael O Dorschner, Keshika Prematilake, Avraham Shaag, Orly Elpeleg, Michael Sacher, Dan Doherty, Simon Edvardson
Progressive childhood encephalopathy is an etiologically heterogeneous condition characterized by progressive central nervous system dysfunction in association with a broad range of morbidity and mortality. The causes of encephalopathy can be either non-genetic or genetic. Identifying the genetic causes and dissecting the underlying mechanisms are critical to understanding brain development and improving treatments. Here, we report that variants in TRAPPC12 result in progressive childhood encephalopathy. Three individuals from two unrelated families have either a homozygous deleterious variant (c...
August 3, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28752054/serotonergic-modulation-of-the-activity-of-glp-1-producing-neurons-in-the-nucleus-of-the-solitary-tract-in-mouse
#20
Marie K Holt, Ida J Llewellyn-Smith, Frank Reimann, Fiona M Gribble, Stefan Trapp
OBJECTIVE: Glucagon-like peptide-1 (GLP-1) and 5-HT are potent regulators of food intake within the brain. GLP-1 is expressed by preproglucagon (PPG) neurons in the nucleus tractus solitarius (NTS). We have previously shown that PPG neurons innervate 5-HT neurons in the ventral brainstem. Here, we investigate whether PPG neurons receive serotonergic input and respond to 5-HT. METHODS: We employed immunohistochemistry to reveal serotonergic innervation of PPG neurons...
August 2017: Molecular Metabolism
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