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Synechia heparin k

Viraj A Vasavada, Mamidipudi R Praveen, Sajani K Shah, Rupal H Trivedi, Abhay R Vasavada
PURPOSE: To determine if intraocular infusion of low-molecular-weight heparin (enoxaparin) reduces postoperative inflammation in pediatric eyes undergoing cataract surgery with IOL implantation. DESIGN: Prospective masked randomized controlled trial. METHODS: setting: Private, institutional practice. study population: Twenty children (40 eyes) undergoing bilateral cataract surgery with IOL implantation were randomized to receive enoxaparin in the intraocular infusion fluid (BSS) (Group I) or not to receive enoxaparin (Group II)...
August 2012: American Journal of Ophthalmology
Yelda B Ozkurt, Arzu Taşkiran, Nadire Erdogan, Baran Kandemir, Omer K Doğan
PURPOSE: To evaluate the influence of irrigation of the anterior chamber with heparin sodium on postoperative inflammation after pediatric cataract surgery. SETTING: Kartal Training and Research Hospital, First Eye Clinic, Istanbul, Turkey. DESIGN: Randomized prospective double-blind study. METHODS: Fourteen consecutive eyes from 14 patients aged 8.9 +/- 5.9 years, (range 3-18 years) (group 1) and 19 eyes from 19 patients aged 9...
2009: Clinical Ophthalmology
S Basti, M K Aasuri, M K Reddy, P Preetam, S Reddy, S Gupta, T J Naduvilath
PURPOSE: To evaluate the performance of heparin-surface-modified (HSM) intraocular lenses (IOLs) in pediatric eyes after cataract surgery. SETTING: L.V. Prasad Eye Institute, Hyderabad, India. METHODS: This prospective, randomized, double-masked, controlled clinical trial comprised 90 children aged 2 to 14 years with cataract. The patients were consecutively randomized to receive an HSM (Group 1) or an unmodified (Group 2) poly(methyl methacrylate) (PMMA) IOL...
June 1999: Journal of Cataract and Refractive Surgery
K F Tabbara, A S Al-Kaff, A A Al-Rajhi, S M Al-Mansouri, I A Badr, P S Chavis, O M Al-Omar
OBJECTIVE: This study aimed to determine whether heparin surface-modified (HSM) intraocular lenses (IOLs) with a hydrophilic surface would reduce cell adherence and other postoperative changes compared with the conventional polymethylmethacrylate (PMMA) IOLs in patients with either diabetes mellitus or inactive uveitis. DESIGN: The study design was a randomized, double-masked, clinical trial. PARTICIPANTS: Twenty-five patients with bilateral cataracts, 14 with inactive anterior uveitis and 11 with diabetes, with an age range of 11 to 81 years (mean, 52...
May 1998: Ophthalmology
B Dick, T Kohnen, K W Jacobi
BACKGROUND: In the last years heparin surface-modified intraocular lenses (HSM IOLs) were used for special indications like uveitis, synechia, congenital cataract or pseudoexfoliation syndrome. A monolayer of heparin molecules on the surface of PMMA-IOLs causes a reduced postoperative inflammatory reaction and produces a higher long-term biocompatibility than PMMA-IOLs without surface-modification. The study was designed to evaluate the possible damage of this heparin-monolayer on the PMMA-IOL by different metallic implantation forceps and different grasp-pressure...
June 1995: Klinische Monatsblätter Für Augenheilkunde
T Kohnen, B Dick, K W Jacobi
UNLABELLED: Surface modification of intraocular lenses (IOL) have improved the quality of cataract surgery. Heparin surface-modified (HSM) IOL are implanted for special indications (e.g., recurrent uveitis, cataract surgery for children, preoperative synechia) because of decreased postoperative inflammatory reactions and higher long-term biocompatibility. Nevertheless, secondary cataract, precipitates and fibrinous membranes appear. The YAG laser is used for treatment. METHODS: PMMA intraocular lenses with or without a heparin monolayer were exposed to Nd:YAG laser...
June 1995: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
R Larsson, G Selén, H Björdklund, P Fagerholm
Intraocular lenses (IOL) were surface modified with covalently linked heparin. The surface-bound heparin could not be removed by incubation in solutions known to be effective in breaking non-covalent bonds, nor by incubation in a solution of proteinase K and only to a limited extent by incubation with heparinase. In vitro studies demonstrated improved biocompatibility by the heparin surface-modified lens with respect to outgrowth of fibroblasts and macrophages, activation of granulocytes and adhesion of platelets...
October 1989: Biomaterials
M Borgioli, D J Coster, R F Fan, J Henderson, K W Jacobi, G R Kirkby, Y K Lai, J L Menezo, M Montard, J Strobel
PURPOSE: A heparin surface modified posterior chamber intraocular lens (IOL) was compared with a conventional polymethylmethacrylate (PMMA) IOL regarding postoperative complications caused by inflammation. METHODS: Five hundred twenty-four patients from 10 different centers were included in a parallel group, double-masked, multicenter study. RESULTS: The cumulative number of patients with inflammatory cellular deposits on their IOLs during the first postoperative year differed significantly in favor of the heparin surface modified group, with 29...
August 1992: Ophthalmology
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