#1
RANDOMIZED CONTROLLED TRIAL
Nicola Ferri, Marco Pappagallo, Sheetal Patel, Franco Folli, Sara De Martin, Maria Giovanna Lupo, Sergio Traversa, Paolo L Manfredi
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality. Hyperlipidemia and vascular subinflammation play critical roles in the pathogenesis of atherosclerosis. Patients with Major Depressive Disorder (MDD) are at higher risk for ASCVD and current antidepressant therapies may carry ASCVD risks. REL-1017 is a novel NMDAR channel blocker which showed rapid, robust, and sustained antidepressant effects, currently in Phase 3 clinical trials for MDD...
April 2022: CNS Spectrums
#2
JOURNAL ARTICLE
M O Yilmaz, F O Keles
OBJECTIVES: Although the data in the literature regarding the etiopathogenesis of adrenal adenomas are scarce, the neutrophil/lymphocyte ratio (NLR) is an easy-to-calculate parameter that has gained popularity in recent years as an indicator of subinflammation. In this study, we aimed to show the changes in NLR in patients with adrenal incidentaloma. METHODS: The anamnesis, laboratory and radiology records of the patients with adrenal incidentaloma in the last 1 year were examined...
2021: Bratislavské Lekárske Listy
#3
JOURNAL ARTICLE
Aafia Rashid, Akbar Masood, Ishfaq A Wani, Imran Hafeez, Tabasum Parvez, Mohd Afzal Zagar, Mohd Ashraf Ganie
OBJECTIVE: To quantitate left ventricular mass index (LVMI) and correlate it with inflammation, insulin resistance (IR) and serum androgen levels among nonobese normotensive women with polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional study SETTING: Tertiary care institute in North India PATIENTS: A total of 260 drug-naive women qualifying the Rotterdam 2003 criteria for diagnosis of PCOS and 250 apparently healthy women matched for age and body mass index (BMI)...
June 2020: Fertility and Sterility
#4
JOURNAL ARTICLE
Ayse Arduc, Bercem Aycicek Dogan, Sevgi Bilmez, Narin Imga Nasiroglu, Mazhar Muslum Tuna, Serhat Isik, Dilek Berker, Serdar Guler
OBJECTIVE: Some similar factors, such as genetic susceptibility and subinflammation/autoimmunity, contribute to development of both polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT), suggesting a potential pathogenic link between the two common disorders. In this study, we investigated the relationship between PCOS and HT, considering the possible effect of PCOS-related hormonal and metabolic factors on thyroid autoimmunity. METHODS: Eighty-six reproductive-age women diagnosed with PCOS according to Rotterdam criteria and 60 age-BMI matched control women were included in the study...
2015: Endocrine Research
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