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https://www.readbyqxmd.com/read/29695980/cardiac-remodeling-endothelial-cells-have-more-to-say-than-just-no
#1
REVIEW
Vincent F M Segers, Dirk L Brutsaert, Gilles W De Keulenaer
The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides the opportunity of intercellular communication within the organ, with subsequent optimization of its function. Intercellular cross-talk is indispensable during cardiac development, but also plays a substantial modulatory role in the normal and failing heart of adults. More specifically, factors secreted by cardiac microvascular endothelial cells modulate cardiac performance and either positively or negatively affect cardiac remodeling...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29690638/neurotensin-is-a-lipid-induced-gastrointestinal-peptide-associated-with-visceral-adipose-tissue-inflammation-in-obesity
#2
Ilaria Barchetta, Flavia Agata Cimini, Danila Capoccia, Laura Bertoccini, Valentina Ceccarelli, Caterina Chiappetta, Frida Leonetti, Claudio Di Cristofano, Gianfranco Silecchia, Marju Orho-Melander, Olle Melander, Maria Gisella Cavallo
Neurotensin (NT) is a 13-amino acid peptide localized in the neuroendocrine cells of the small intestine, which promotes fat absorption and fatty acids translocation in response to lipid ingestion. NT-knock-out mice fed with a high-fat diet are protected from obesity, fatty liver, and the development of insulin-resistance. In humans, higher plasma levels of pro-NT, which is the stable circulating precursor of NT, predict obesity, type 2 diabetes (T2D), and cardiovascular disease. In obesity, the presence of visceral adipose tissue (VAT) inflammation leads to unfavorable metabolic outcomes and is associated with the development of T2D and non-alcoholic fatty liver disease (NAFLD)...
April 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29627497/osteoblast-secreted-wisp-1-promotes-adherence-of-prostate-cancer-cells-to-bone-via-the-vcam-1-integrin-%C3%AE-4%C3%AE-1-system
#3
An-Chen Chang, Po-Chun Chen, Yu-Feng Lin, Chen-Ming Su, Ju-Fang Liu, Tien-Huang Lin, Show-Mei Chuang, Chih-Hsin Tang
Bone metastasis is a frequent occurrence in prostate cancer (PCa) that is associated with severe complications such as fracture, bone pain and hypercalcemia. The cross-talk between metastatic cancer cells and bone is critical to the development and progression of bone metastases. In our previous data, we have described how the involvement of the Wnt-induced secreted protein-1/vascular cell adhesion molecule-1 (WISP-1/VCAM-1) system in this tumor-bone interaction contributes to human PCa cell motility. In this study, we found that WISP-1 regulates bone mineralization by inducing bone morphogenetic protein-2 (BMP2), BMP4 and osteopontin (OPN) expression in osteoblasts...
April 5, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29540606/hyperintense-plaque-on-intracranial-vessel-wall-magnetic-resonance-imaging-as-a-predictor-of-artery-to-artery-embolic-infarction
#4
Fang Wu, Haiqing Song, Qingfeng Ma, Jiayu Xiao, Tao Jiang, Xiaoqin Huang, Xiaoming Bi, Xiuhai Guo, Debiao Li, Qi Yang, Xunming Ji, Zhaoyang Fan
BACKGROUND AND PURPOSE: The aim of the present study was to investigate atherosclerotic plaque characteristics in patients with artery-to-artery (A-to-A) embolic infarction by whole-brain high-resolution magnetic resonance imaging. METHODS: Seventy-four patients (mean age, 54.7±12.1 years; 59 men) with recent stroke in the territory of middle cerebral artery because of intracranial atherosclerotic disease were prospectively enrolled. Whole-brain high-resolution magnetic resonance imaging was performed in all the patients both precontrast and postcontrast administration by using a 3-dimensional T1-weighted vessel wall magnetic resonance imaging technique known as inversion-recovery prepared sampling perfection with application-optimized contrast using different flip angle evolutions...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29506624/ccn3-a-key-matricellular-protein-distinctly-inhibits-tgf%C3%AE-1-mediated-smad1-5-8-signalling-in-human-podocyte-culture
#5
Tarunkumar Hemraj Madne, Mark Edward Carl Dockrell
Growth factors like TGFβ and CTGF (CCN2) plays a vital role in various cellular functions. TGFβ and CTGF are overexpressed in renal fibrosis. CTGF act as profibrotic stimuli to TGFβ. CCN3 is a member of CCN family which also comprises CCN1 (CYR61), CCN2 (CTGF), CCN4 (WISP-1), CCN5 (WISP-2) and CCN6 (WISP-3). CCN3 has been shown to antagonise CTGF. In this study, we investigated the role of CCN3 in TGFβ1-mediated signalling in human podocytes culture. This study describes the novel function of CCN3 in regulation of TGFβ1 mediated non-canonical Smad signalling in human podocytes culture...
February 28, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29471595/procollagen-iii-peptide-identifies-adipose-tissue-associated-inflammation-in-type-2-diabetes-with-or-without-nonalcoholic-liver-disease
#6
I Barchetta, F A Cimini, R De Gioannis, G Ciccarelli, L Bertoccini, A Lenzi, M G Baroni, M G Cavallo
BACKGROUND: Procollagen-III peptide (PIIINP) is a marker of fibrosis associated with increased cardiometabolic risk and progression of chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) and steatohepatitis; its association with type 2 diabetes mellitus (T2DM) has not been elucidated yet. The aim of this study was to investigate the relationship among circulating PIIINP levels, metabolic traits, and body fat distribution in subjects with T2DM with or without NAFLD...
February 22, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29467324/angiokine-wisp-1-is-increased-in-myocardial-infarction-and-regulates-cardiac-endothelial-signaling
#7
Lillianne H Wright, Daniel J Herr, Symone S Brown, Harinath Kasiganesan, Donald R Menick
Myocardial infarctions (MIs) cause the loss of myocytes due to lack of sufficient oxygenation and latent revascularization. Although the administration of histone deacetylase (HDAC) inhibitors reduces the size of infarctions and improves cardiac physiology in small-animal models of MI injury, the cellular targets of the HDACs, which the drugs inhibit, are largely unspecified. Here, we show that WNT-inducible secreted protein-1 (Wisp-1), a matricellular protein that promotes angiogenesis in cancers as well as cell survival in isolated cardiac myocytes and neurons, is a target of HDACs...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29180663/a-large-and-distinct-skin-impression-on-the-cast-of-a-sauropod-dinosaur-footprint-from-early-cretaceous-floodplain-deposits-korea
#8
In Sung Paik, Hyun Joo Kim, Hoil Lee, Seongyeong Kim
The occurrence and features of skin impressions in a sauropod footprint, the largest (>50 cm in diameter) reported to date for this taxon, from the Lower Cretaceous Haman Formation (Albian) in Korea are described, and its preservation and paleoenvironmental implications are interpreted. The skin impression-bearing deposits are floodplain sediments formed by sheetflood processes. The large impression is preserved in silty mudstone with microbial lenses and wisps overlying a planar- to cross-laminated and fine-grained sandstone to siltstone bed...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29129025/assessment-of-circulating-wnt1-inducible-signalling-pathway-protein-1-wisp-1-ccn4-as-a-novel-biomarker-of-obesity
#9
Christopher Tacke, Krasimira Aleksandrova, Miriam Rehfeldt, Veronica Murahovschi, Mariya Markova, Margrit Kemper, Silke Hornemann, Ulrike Kaiser, Caroline Honig, Christiana Gerbracht, Stefan Kabisch, Tina Hörbelt, D Margriet Ouwens, Martin O Weickert, Heiner Boeing, Andreas F H Pfeiffer, Olga Pivovarova, Natalia Rudovich
WNT1 inducible signaling pathway protein 1 (WISP-1/CCN4) is a novel adipokine, which is upregulated in obesity, and induces a pro-inflammatory response in macrophages in-vitro. Preclinical observations suggested WISP-1/CCN4 as a potential candidate for novel obesity therapy targeting adipose tissue inflammation. Whether circulating levels of WISP-1/CCN4 in humans are altered in obesity and/or type 2 diabetes (T2DM) and in the postprandial state, however, is unknown. This study assessed circulating WISP-1/CCN4 levels in a) paired liquid meal tests and hyperinsulinemic- euglycemic clamps (cohort I, n = 26), b) healthy individuals (cohort II, n = 207) and c) individuals with different stages of obesity and glucose tolerance (cohort III, n = 253)...
November 11, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29089076/-screening-of-key-molecules-of-hab18g-cd147-signal-transduction-pathway-in-human-hepatoma-cells
#10
Hongwei Zhou, Yibing Yao, Yaojie Liang, Zhihong Wang, Xiaoyan Zhou, Weiping Guo, Xiangmin Yang, Jianli Jiang, Junzhong Sun, Zhinan Chen
Objective To screen the differentially expressed key molecules of HAb18G/CD147 signal transduction pathway in human hepatoma cells. Methods The total RNA was extracted from SMMC-7721 and T7721 cells, which were stably transfected and overexpressed HAb18G/CD147, and then detected by signal transduction-related microarray to identify differentially expressed key molecules. Results The microarray data indicated that there were 13 differentially expressed genes between T7721 and SMMC-7721 cells. In T7721 cell line which overexpressed HAb18G/CD147, the down-regulated genes included bone morphogenetic protein-2 (BMP-2), BMP-5, endothelin-1 (ET-1), Wnt1-induced signaling proteins-2/CCN5 (WISP-2), cysteine-rich 61/CCN1 (Cyr61), prostate stem cell antigen (PSCA), and the up-regulated genes included interleukin-10 receptor α (IL-10Rα), IL-6, IL-8, CXCL2, mitochondrial superoxide dismutase 2 (SOD2), B factor and βig-h3...
September 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29020424/characterization-of-artifacts-associated-with-multicolor-confocal-scanning-laser-ophthalmoscopy
#11
Henry L Feng, Sumit Sharma, Sandra Stinnett, Sanjay Asrani, Prithvi Mruthyunjaya
BACKGROUND AND OBJECTIVE: To characterize the appearance of three types of artifacts observed on multicolor confocal scanning laser ophthalmoscopy (cSLO). PATIENTS AND METHODS: Retrospective review of 159 eyes of 96 consecutive patients from the Duke Eye Center who underwent multicolor cSLO with spectral-domain optical coherence tomography (SD-OCT). Infrared (IR), green, blue, and multicolor reflectance images were evaluated for artifacts with corresponding SD-OCT scans available for reference...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28887739/an-evaluation-of-a-handheld-spectroradiometer-for-the-near-real-time-measurement-of-cyanobacteria-for-bloom-management-purposes
#12
Lee C Bowling, Mustak Shaikh, John Brayan, Tim Malthus
A commercially available handheld spectroradiometer, the WISP-3, was assessed as a tool for monitoring freshwater cyanobacterial blooms for management purposes. Three small eutrophic urban ponds which displayed considerable within-pond and between-pond variability in water quality and cyanobacterial community composition were used as trial sites. On-board algorithms provide field measurements of phycocyanin (CPC) and chlorophyll-a (Chl-a) from surface reflectance spectra measured by the instrument. These were compared with laboratory measurements...
September 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28783045/macrophage-derived-il-10-mediates-mucosal-repair-by-epithelial-wisp-1-signaling
#13
Miguel Quiros, Hikaru Nishio, Philipp A Neumann, Dorothee Siuda, Jennifer C Brazil, Veronica Azcutia, Roland Hilgarth, Monique N O'Leary, Vicky Garcia-Hernandez, Giovanna Leoni, Mingli Feng, Gabriela Bernal, Holly Williams, Priya H Dedhia, Christian Gerner-Smidt, Jason Spence, Charles A Parkos, Timothy L Denning, Asma Nusrat
In response to injury, epithelial cells migrate and proliferate to cover denuded mucosal surfaces and repair the barrier defect. This process is orchestrated by dynamic crosstalk between immune cells and the epithelium; however, the mechanisms involved remain incompletely understood. Here, we report that IL-10 was rapidly induced following intestinal mucosal injury and was required for optimal intestinal mucosal wound closure. Conditional deletion of IL-10 specifically in CD11c-expressing cells in vivo implicated macrophages as a critical innate immune contributor to IL-10-induced wound closure...
September 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28744885/water-infused-surface-protection-as-an-active-mechanism-for-fibrin-sheath-prevention-in-central-venous-catheters
#14
David W Sutherland, Xin Zhang, Joseph L Charest
Protein adhesion in central venous catheters (CVCs) leads to fibrin sheath formation, the precursor to thrombotic and biofilm-related CVC failures. Advances in material properties and surface coatings do not completely prevent fibrin sheath formation and post-formation treatment options are limited and expensive. We propose water infused surface protection (WISP), an active method for prevention of fibrin sheath formation on CVCs, which creates a blood-free boundary layer on the inner surface of the CVC, limiting blood contact with the CVC lumen wall...
July 26, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28670380/serum-levels-of-wnt1-inducible-signaling-pathway-protein-1-wisp-1-a-noninvasive-biomarker-of-renal-fibrosis-in-subjects-with-chronic-kidney-disease
#15
Xiang Zhong, Yue Ju Tu, Yi Li, Ping Zhang, Wei Wang, Sha Sha Chen, Li Li, Arthur Ck Chung, Hui Yao Lan, Hai Yong Chen, Gui Sen Li, Li Wang
WNT1-inducible signaling pathway protein-1 (WISP-1) is an extracellular matrix-related protein that plays multiple roles in cellular physiology and pathology. Accumulating evidence shows that WISP-1 is involved in the process underlying fibrotic diseases. However, the correlation between WISP-1 and renal fibrosis is unknown. In this study, we hypothesized that WISP-1 levels might be correlated with renal fibrosis and could be used as a noninvasive biomarker to screen for renal fibrosis in patients with chronic kidney disease (CKD)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28535825/the-effect-of-increased-fruit-and-vegetable-consumption-on-selected-macronutrient-and-micronutrient-intakes-in-four-randomised-controlled-trials
#16
RANDOMIZED CONTROLLED TRIAL
Sharon L Fulton, Michelle C McKinley, Charlotte E Neville, Francina R Baldrick, Ciara Mulligan, Damian O McCall, David R McCance, J D Edgar, J S Elborn, Ian S Young, Chris C Patterson, Jayne V Woodside
Fruit and vegetable (FV) intake is associated with reduced risk of a number of non-communicable diseases. Research tends to focus on antioxidants, flavonoids and polyphenols contained in FV as the main beneficial components to health; however, increasing FV may also alter overall diet profile. Extra FV may be substituted for foods thought to be less healthy, therefore altering the overall macronutrient and/or micronutrient content in the diet. This analysis merged dietary data from four intervention studies in participants with varying health conditions and examined the effect of increased FV consumption on diet profile...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28530705/ccn5-wisp-2-restores-er-%C3%A2-in-normal-and-neoplastic-breast-cells-and-sensitizes-triple-negative-breast-cancer-cells-to-tamoxifen
#17
S Sarkar, A Ghosh, S Banerjee, G Maity, A Das, M A Larson, V Gupta, I Haque, O Tawfik, S K Banerjee
CCN5/WISP-2 is an anti-invasive molecule and prevents breast cancer (BC) progression. However, it is not well understood how CCN5 prevents invasive phenotypes of BC cells. CCN5 protein expression is detected in estrogen receptor-α (ER-α) -positive normal breast epithelial cells as well as BC cells, which are weakly invasive and rarely metastasize depending on the functional status of ER-α. A unique molecular relation between CCN5 and ER-α has been established as the components of the same signaling pathway that coordinate some essential signals associated with the proliferation as well as delaying the disease progression from a non-invasive to invasive phenotypes...
May 22, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28465477/wisp-3-inhibition-of-mir-452-promotes-vegf-a-expression-in-chondrosarcoma-cells-and-induces-endothelial-progenitor-cells-angiogenesis
#18
Chih-Yang Lin, Huey-En Tzeng, Te-Mao Li, Hsien-Te Chen, Yi Lee, Yi-Chen Yang, Shih-Wei Wang, Wei-Hung Yang, Chih-Hsin Tang
Chondrosarcoma is the second most prevalent general primary tumor of bone following osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is principally elicited by vascular endothelial growth factor-A (VEGF-A). VEGF-A level has been recognized as a prognostic marker in angiogenesis. WNT1-inducible signaling pathway protein-3 (WISP)-3/CCN6 belongs to the CCN family and is involved in regulating several cellular functions, including cell proliferation, differentiation, and migration. Nevertheless, the effect of WISP-3 on VEGF-A production and angiogenesis in human chondrosarcoma remains largely unknown...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28450698/deficiency-of-ccn5-wisp-2-driven-program-in-breast-cancer-promotes-cancer-epithelial-cells-to-mesenchymal-stem-cells-and-breast-cancer-growth
#19
Amlan Das, Kakali Dhar, Gargi Maity, Sandipto Sarkar, Arnab Ghosh, Inamul Haque, Gopal Dhar, Snigdha Banerjee, Sushanta K Banerjee
Breast cancer progression and relapse is conceivably due to tumor initiating cells (TICs)/cancer stem cells. EMT (epithelial-mesenchymal-transition)-signaling regulates TICs' turnover. However, the mechanisms associated with this episode are unclear. We show that, in triple-negative-breast cancer (TNBC) cells enriched with TICs, CCN5 significantly blocks cellular growth via apoptosis, reversing EMT-signaling and impairing mammosphere formation, thereby blocking the tumor-forming ability and invasive capacity of these cells...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446235/differential-expression-of-cell-cycle-and-wnt-pathway-related-genes-accounts-for-differences-in-the-growth-and-differentiation-potential-of-wharton-s-jelly-and-bone-marrow-derived-mesenchymal-stem-cells
#20
Aristea K Batsali, Charalampos Pontikoglou, Dimitrios Koutroulakis, Konstantia I Pavlaki, Athina Damianaki, Irene Mavroudi, Kalliopi Alpantaki, Elisavet Kouvidi, George Kontakis, Helen A Papadaki
BACKGROUND: In view of the current interest in exploring the clinical use of mesenchymal stem cells (MSCs) from different sources, we performed a side-by-side comparison of the biological properties of MSCs isolated from the Wharton's jelly (WJ), the most abundant MSC source in umbilical cord, with bone marrow (BM)-MSCs, the most extensively studied MSC population. METHODS: MSCs were isolated and expanded from BM aspirates of hematologically healthy donors (n = 18) and from the WJ of full-term neonates (n = 18)...
April 26, 2017: Stem Cell Research & Therapy
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