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https://www.readbyqxmd.com/read/27897112/harnessing-the-power-of-sirt1-and-non-coding-rnas-in-vascular-disease
#1
Kenneth Maiese
Noncommunicable diseases (NCDs) contribute to a significant amount of disability and death in the world. Of these disorders, vascular disease is ranked high, falls within the five leading causes of death, and impacts multiple other disease entities such as those of the cardiac system, nervous system, and metabolic disease. Targeting the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) pathway and the modulation of micro ribonucleic acids (miRNAs) may hold great promise for the development of novel strategies for the treatment of vascular disease since each of these pathways are highly relevant to cardiac and nervous system disorders as well as to metabolic dysfunction...
November 29, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27895739/gene-expression-profiling-of-the-8q22-24-position-in-human-breast-cancer-tspyl5-mtdh-atad2-and-ccne2-genes-are-implicated-in-oncogenesis-while-wisp1-and-ext1-genes-may-predict-a-risk-of-metastasis
#2
Afsoon Taghavi, Mohammad Esmaeil Akbari, Mohammad Hashemi-Bahremani, Nahid Nafissi, Ahad Khalilnezhad, Seyed Mohammad Poorhosseini, Feyzollah Hashemi-Gorji, Vahid Reza Yassaee
Gene expression profiling has been suggested to predict breast cancer outcome. The prognostic value of the 8q22-24 position in breast cancer remains to be elucidated. The present study evaluated expression patterns of the genes located at this position in metastatic and non-metastatic breast cancer. A total of 85 patients with recurrent/metastatic (n=15) and non-metastatic (n=70) early-stage, estrogen receptor-positive and lymph node-negative breast tumors were included. In addition, 15 normal breast tissue samples were used as controls...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27829832/members-of-the-cyr61-ctgf-nov-protein-family-emerging-players-in-hepatic-progenitor-cell-activation-and-intrahepatic-cholangiocarcinoma
#3
Qunfeng Wu, Marda Jorgensen, Joanna Song, Junmei Zhou, Chen Liu, Liya Pi
Hepatic stem/progenitor cells (HPC) reside quiescently in normal biliary trees and are activated in the form of ductular reactions during severe liver damage when the replicative ability of hepatocytes is inhibited. HPC niches are full of profibrotic stimuli favoring scarring and hepatocarcinogenesis. The Cyr61/CTGF/NOV (CCN) protein family consists of six members, CCN1/CYR61, CCN2/CTGF, CCN3/NOV, CCN4/WISP1, CCN5/WISP2, and CCN6/WISP3, which function as extracellular signaling modulators to mediate cell-matrix interaction during angiogenesis, wound healing, fibrosis, and tumorigenesis...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27728876/a-pharmacological-mouse-model-suggests-a-novel-risk-pathway-for-postpartum-psychosis
#4
Trevor Humby, Ellen S Cross, Lauren Messer, Silvia Guerrero, William Davies
Postpartum psychosis (PP) is a severe psychiatric disorder affecting a small proportion of new mothers shortly after childbirth. The molecular pathophysiology underlying the disorder is currently poorly understood, and there are no amenable animal models for the condition; maternal deficiency for the enzyme steroid sulfatase has been proposed as a potential risk mechanism. Here we show that inhibition of steroid sulfatase with 667-COUMATE (10mg/kg p.o.) in new mouse mothers results in behavioural abnormalities that can be partially alleviated by the administration of the clinically-efficacious antipsychotic ziprasidone (0...
September 28, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27690684/novel-adipokines-wisp1-and-betatrophin-in-pcos-relationship-to-amh-levels-atherogenic-and-metabolic-profile
#5
Gulcin Sahin Ersoy, Tugba Altun Ensari, Dogan Vatansever, Volkan Emirdar, Ozge Cevik
OBJECTIVE: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Müllerian hormone (AMH) levels, atherogenic profile and metabolic parameters Methods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle...
September 30, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27520547/dual-roles-of-ccn-proteins-in-breast-cancer-progression
#6
Celina G Kleer
The tumor microenvironment has a powerful effect on the development and progression of human breast cancer, which may be used therapeutically. Despite efforts to understand the complex role of the tumor microenvironment in breast cancer development, the specific players and their contributions to tumorigenesis need further investigation. The CCN family of matricellular proteins comprises six members (CCN1-6; CYR61, CTGF, NOV, WISP1-3) with central roles in development, inflammation, and tissue repair. CCN proteins also exert functions during pathological processes including fibrosis and cancer by regulating extracellular signals in the cellular environment...
September 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27466505/pten-insufficiency-increases-breast-cancer-cell-metastasis-in-vitro-and-in-vivo-in-a-xenograft-zebrafish-model
#7
Kun-Chun Chiang, Shu-Yuan Hsu, Sheng-Jia Lin, Chun-Nan Yeh, Jong-Hwei S Pang, Shang-Yu Wang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Yi-Chuan Cheng, Horng-Heng Juang
BACKGROUND/AIM: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) insufficiency is commonly found in breast cancer patients with metastasis. We investigated the mechanisms by which PTEN affects breast cancer metastatic behavior. MATERIALS AND METHODS: Migration and invasion assay, western blot, immunofluorescent staining and zebrafish animal model were applied. RESULTS: We showed that PTEN insufficiency induced an increase in MCF-7 cell migration and invasion through induction of epithelial-mesenchymal transition (EMT), which was triggered by up-regulation of the EMT-inducing transcriptional factors Zeb1, Zeb2, Snail, Slug and Twist...
August 2016: Anticancer Research
https://www.readbyqxmd.com/read/27409174/high-expression-of-wisp1-in-colon-cancer-is-associated-with-apoptosis-invasion-and-poor-prognosis
#8
Jianghong Wu, Ziwen Long, Hong Cai, Chunyan Du, Xiaowen Liu, Shengjia Yu, Yanong Wang
Colon cancer (CC) likes many epithelial-derived cancers, resulting from a complex tumorigenic process. However, the exactly mechanisms of development and progression of CC are still unknown. In this study, integrated analysis in the GSE33113 and Fudan University Shanghai Cancer Center Hospital datasets revealed that WISP1 expression was significantly increased in CC cases, positivity correlated with the advanced pathologic stage and a poor prognosis was more likely in CC patients with higher levels of WISP1...
July 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27403031/wisp1-is-increased-in-intestinal-mucosa-and-contributes-to-inflammatory-cascades-in-inflammatory-bowel-disease
#9
Qi Zhang, Cuiping Zhang, Xiaoyu Li, Yanan Yu, Kun Liang, Xinzhi Shan, Kun Zhao, Qinghui Niu, Zibin Tian
Inflammatory bowel disease (IBD) is mainly characterized by intestinal tissue damage, which is caused by excessive autoimmune responses poorly controlled by corresponding regulatory mechanisms. WISP1, which belongs to the CCN protein family, is a secreted matricellular protein regulating several inflammatory pathways, such as Wnt/β-catenin pathway, and has been reported in several diseases including cancer. Here we examined the expression, regulatory mechanisms, and functions of WISP1 in IBD. WISP1 mRNA and protein expression was upregulated in colonic biopsies and lamina propria mononuclear cells (LPMC) of IBD patients compared with those of healthy controls...
2016: Disease Markers
https://www.readbyqxmd.com/read/27391264/association-of-genetic-variations-in-the-wnt-signaling-pathway-genes-with-myocardial-infarction-susceptibility-in-chinese-han-population
#10
Jing Tao, Yong-Tao Wang, Mayila Abudoukelimu, Yi-Ning Yang, Xiao-Mei Li, Xiang Xie, Bang-Dang Chen, Fen Liu, Chun-Hui He, Hua-Yin Li, Yi-Tong Ma
: Numerous studies have implicated the Wnt pathway in the development and progression of myocardial infarction (MI); however, there are very few investigations addressing the effects of polymorphisms in the Wnt pathway genes on MI susceptibility. We investigated the possible correlation between genetic variations in Wnt pathway genes and MI risk. Three polymorphisms (rs7832767 C > T in SFRP1 gene, rs2293303 C > T in CTNNB1 gene, rs16893344 C > T in WISP1 gene) were finally selected and genotyped in 465 MI patients and 485 healthy controls, using the PCR-RFLP method...
July 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27390624/forkhead-transcription-factors-new-considerations-for-alzheimer-s-disease-and-dementia
#11
Kenneth Maiese
Life expectancy of individuals in both developed and undeveloped nations continues to rise at an unprecedented rate. Coupled to this increase in longevity for individuals is the rise in the incidence of chronic neurodegenerative disorders that includes Alzheimer's disease (AD). Currently, almost ten percent of the population over the age of 65 suffers from AD, a disorder that is presently without definitive therapy to prevent the onset or progression of cognitive loss. Yet, it is estimated that AD will continue to significantly increase throughout the world to impact millions of individuals and foster the escalation of healthcare costs...
July 2016: Journal of Translational Science
https://www.readbyqxmd.com/read/27349568/wisp1-%C3%AE-v%C3%AE-3-integrin-signaling-positively-regulates-tlr-triggered-inflammation-response-in-sepsis-induced-lung-injury
#12
Zhixia Chen, Xibing Ding, Shuqing Jin, Bruce Pitt, Liming Zhang, Timothy Billiar, Quan Li
We recently noted that the matricellular protein WISP1 contributes to sepsis induced acute lung injury (ALI) via integrin β6. In the current study, we pursued further aspects of WISP1 modulation of TLR signaling in lungs of mice after sepsis and TLR4 mediated release of TNF-α in macrophages. After confirming that TLR4 and CD14 are critical in transducing sepsis mediated ALI, we now demonstrate that intrapulmonary αvβ3 is increased by polymicrobrial sepsis in a TLR4, CD14 dependent fashion. Comparison of cultured macrophages revealed that WISP1 increased release of TNF-α from RAW264...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27321870/wisp1-overexpression-promotes-proliferation-and-migration-of-human-vascular-smooth-muscle-cells-via-akt-signaling-pathway
#13
Shun Lu, Hao Liu, Lihe Lu, Heng Wan, Zhiqi Lin, Kai Qian, Xingxing Yao, Qing Chen, Wenjun Liu, Jianyun Yan, Zhengjun Liu
Proliferation and migration of vascular smooth muscle cells (VSMCs) play crucial roles in the development of vascular restenosis. Our previous study showed that CCN4, namely Wnt1 inducible signaling pathway protein 1 (WISP1), significantly promotes proliferation and migration of rat VSMCs, but its mechanism remains unclear. This study aims to investigate whether and how WISP1 stimulates proliferation and migration of human VSMCs. Western blot analysis showed that FBS treatment increased WISP1 protein levels in human VSMCs in a dose-dependent manner...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27267804/wisp1-is-a-novel-adipokine-linked-to-metabolic-parameters-in-gestational-diabetes-mellitus
#14
Gulcin Sahin Ersoy, Tugba Altun Ensari, Seda Subas, Burak Giray, Engin Ersin Simsek, Ozge Cevik
OBJECTIVE: To investigate Wnt1-inducible signaling pathway protein-1 (WISP1) levels and their correlation with metabolic parameters in pregnant women with gestational diabetes mellitus (GDM) and non-GDM healthy pregnant women. MATERIALS AND METHODS: In this prospective cross-sectional study, the study group was composed of 62 women with GDM and 73 healthy pregnant women matched for age, body mass index (BMI) and gestational age. Blood samples were collected at 25-29th gestational week...
June 8, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27127460/novel-nervous-and-multi-system-regenerative-therapeutic-strategies-for-diabetes-mellitus-with-mtor
#15
REVIEW
Kenneth Maiese
Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy. The mechanistic target of rapamycin (mTOR) is a promising agent for the development of novel regenerative strategies for the treatment of DM. mTOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis, insulin resistance, insulin secretion, stem cell proliferation and differentiation, pancreatic β-cell function, and programmed cell death with apoptosis and autophagy...
March 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27125498/fractionated-irradiation-induced-emt-like-phenotype-conferred-radioresistance-in-esophageal-squamous-cell-carcinoma
#16
Hongfang Zhang, Honglei Luo, Zhenzhen Jiang, Jing Yue, Qiang Hou, Ruifei Xie, Shixiu Wu
The efficacy of radiotherapy, one major treatment modality for esophageal squamous cell carcinoma (ESCC) is severely attenuated by radioresistance. Epithelial-to-mesenchymal transition (EMT) is a cellular process that determines therapy response and tumor progression. However, whether EMT is induced by ionizing radiation and involved in tumor radioresistance has been less studied in ESCC. Using multiple fractionated irradiation, the radioresistant esophageal squamous cancer cell line KYSE-150R had been established from its parental cell line KYSE-150...
July 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27098435/cell-surface-receptors-for-ccn-proteins
#17
REVIEW
Lester F Lau
The CCN family (CYR61; CTGF; NOV; CCN1-6; WISP1-3) of matricellular proteins in mammals is comprised of six homologous members that play important roles in development, inflammation, tissue repair, and a broad range of pathological processes including fibrosis and cancer. Despite considerable effort to search for a high affinity CCN-specific receptor akin to growth factor receptors, no such receptor has been found. Rather, CCNs bind several groups of multi-ligand receptors as characteristic of other matricellular proteins...
June 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27025059/effect-of-hypoxia-on-the-expression-of-genes-that-encode-some-igfbp-and-ccn-proteins-in-u87-glioma-cells-depends-on-ire1-signaling
#18
O H Minchenko, A P Kharkova, D O Minchenko, L L Karbovskyi
We have studied hypoxic regulation of the expression of different insulin-like growth factor binding protein genes in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1), a central mediator of endoplasmic reticulum stress, which controls cell proliferation and tumor growth. We have demonstrated that hypoxia leads to up-regulation of the expression of IGFBP6, IGFBP7, IGFBP10/CYR61, WISP1, and WISP2 genes and down-regulation--of IGFBP9/NOV gene at the mRNA level in control glioma cells, being more signifcant changes for IGFBP10/CYR61 and WISP2 genes...
November 2015: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/27007919/modulation-of-circulating-vasoactive-peptides-and-extracellular-matrix-proteins-are-two-novel-mechanisms-in-the-cardioprotective-action-of-acarbose
#19
Natalia Rudovich, Olga Pivovarova, Wolfgang Bernigau, Andrea Sparwasser, Christopher Tacke, Veronica Murahovshi, Gabriele Mertes, Andreas L Birkenfeld, Andreas Bergmann, Martin O Weickert, Andreas F Pfeiffer
BACKGROUND: Acarbose, an alpha-glucosidase inhibitor, unexpectedly reduced the incidence of hypertension and cardiovascular endpoints in the STOP-NIDDM study. Based on the growing evidence of a link between vasoregulatory peptides and metabolic traits, we hypothesized that changes of the Glycemic Index by acarbose may modulate vasoregulatory peptide levels via regulation of postprandial metabolism. METHODS: Subjects with type 2 diabetes and with metabolic syndrome were treated with acarbose (12 weeks, 300mg/d) in a double-blind, placebo-controlled, cross-over intervention...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/26893943/picking-a-bone-with-wisp1-ccn4-new-strategies-against-degenerative-joint-disease
#20
Kenneth Maiese
As the world's population continues to age, it is estimated that degenerative joint disease disorders such as osteoarthritis will impact at least 130 million individuals throughout the globe by the year 2050. Advanced age, obesity, genetics, gender, bone density, trauma, and a poor level of physical activity can lead to the onset and progression of osteoarthritis. However, factors that lead to degenerative joint disease and involve gender, genetics, epigenetic mechanisms, and advanced age are not within the control of an individual...
2016: Journal of Translational Science
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