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https://www.readbyqxmd.com/read/29455191/smith-lemli-opitz-syndrome-clinical-and-biochemical-correlates
#1
Sarah E Donoghue, James J Pitt, Avihu Boneh, Susan M White
BACKGROUND: Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder caused by mutations in the DHCR7 gene that result in reduced cholesterol biosynthesis. The aim of the study was to examine the biochemical and clinical features of SLOS in the context of the emerging evidence of the importance of cholesterol in morphogenesis and steroidogenesis. METHODS: We retrospectively reviewed the records of 18 patients (including four fetuses) with confirmed SLOS and documented their clinical and biochemical features...
February 19, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29454738/-satellite-center-of-human-milk-analysis-of-cost-reduction
#2
L Affumicato, T Sánchez Tamayo, M G Espinosa Fernandez, M Peña Caballero, C E Ruiz Morcillo, R Acebes Tosti, E Salguero García
INTRODUCTION: Donor milk is the second best alternative for a newborn after the mother's own milk, especially when the baby is a premature or a sick child since this milk has the advantage of protecting against necrotizing enterocolitis. There are currently 13 milk banks in Spain, however this is not sufficient to supply all Spanish neonatal units with donor milk. In order to bring donor milk to the babies in Neonatal Unit of the Regional University Hospital of Malaga, a Satellite Centre (CS) was created in 2012, depending on the Milk Bank of Virgen de las Nieves Hospital in Granada...
February 14, 2018: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29454185/preterm-infants-undergoing-laparotomy-for-necrotizing-enterocolitis-or-spontaneous-intestinal-perforation-display-evidence-of-impaired-cerebrovascular-autoregulation
#3
Sara J Kuik, Michelle E van der Laan, Margot T Brouwer-Bergsma, Jan B F Hulscher, Anthony R Absalom, Arend F Bos, Elisabeth M W Kooi
BACKGROUND: Preterm infants requiring surgery are at risk of impaired neurocognitive development caused, possibly, by cerebral ischemia associated with impaired cerebrovascular autoregulation (CAR). We evaluated CAR before, during, and after laparotomy. STUDY DESIGN: This was a hypothesis generating prospective observational cohort study. SUBJECTS: We included preterm infants requiring surgery for necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP)...
February 14, 2018: Early Human Development
https://www.readbyqxmd.com/read/29451823/evaluation-of-fetal-intestinal-cell-growth-and-antimicrobial-biofunctionalities-of-donor-human-milk-after-preparative-processes
#4
Pasinee Kanaprach, Nutkridta Pongsakul, Nopporn Apiwattanakul, Chatchai Muanprasat, Sarayut Supapannachart, Pracha Nuntnarumit, Somchai Chutipongtanate
BACKGROUND: Donor human milk is considered the next best nutrition following mother's own milk to prevent neonatal infection and necrotizing enterocolitis in preterm infants who are admitted at neonatal intensive care unit. However, donor milk biofunctionalities after preparative processes have rarely been documented. OBJECTIVE: To evaluate biofunctionalities preserved in donor milk after preparative processes by cell-based assays. MATERIALS AND METHODS: Ten pools of donor milk were produced from 40 independent specimens...
February 16, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29451716/improving-growth-for-infants-%C3%A2-1250-grams-receiving-an-exclusive-human-milk-diet
#5
Robert K Huston, Andrea M Markell, Elizabeth A McCulley, Stuart K Gardiner, Sean L Sweeney
BACKGROUND: An exclusive human milk diet (EHM) fortified with human milk-based fortifier decreases necrotizing enterocolitis (NEC) compared to maternal milk supplemented with preterm formula and bovine fortifier (PTF). Growth has been less with EHM and also maternal milk supplemented with donor human milk and bovine fortifier (HMBF). The objective was to evaluate the effect of a standardized feeding protocol on the growth of infants ≤1250 g birth weight supported with EHM and HMBF. The effect on the incidence of NEC was also evaluated...
February 16, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29444139/post-discharge-body-weight-and-neurodevelopmental-outcomes-among-very-low-birth-weight-infants-in-taiwan-a-nationwide-cohort-study
#6
Chung-Ting Hsu, Chao-Huei Chen, Ming-Chih Lin, Teh-Ming Wang, Ya-Chi Hsu
BACKGROUND: Premature infants are at high risk for developmental delay and cognitive dysfunction. Besides medical conditions, growth restriction is regarded as an important risk factor for cognitive and neurodevelopmental dysfunction throughout childhood and adolescence and even into adulthood. In this study, we analyzed the relationship between post-discharge body weight and psychomotor development using a nationwide dataset. MATERIALS AND METHODS: This was a nationwide cohort study conducted in Taiwan...
2018: PloS One
https://www.readbyqxmd.com/read/29434061/immediate-neonatal-outcomes-of-preterm-infants-born-to-mothers-with-preterm-pre-labour-rupture-of-membranes
#7
Niveditha Dannapaneni, Tejopratap Oleti, Tarakeswari Surapaneni, Deepak Sharma, Srinivas Murki
Background & objectives: With the use of early and appropriate use of antibiotics, outcomes have improved in the mother-infant dyads exposed to preterm pre-labour rupture of membranes (PPROM). This study was undertaken to evaluate immediate neonatal outcomes in infants born before 33 completed weeks of gestation to mothers with PPROM versus without PPROM. Methods: During the study period from January 2013 to December 2013, a total of 182 mother-infant dyads were prospectively included in the study...
October 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29433145/effect-of-cord-blood-magnesium-level-at-birth-on-non-neurologic-neonatal-outcomes
#8
James M Edwards, Laura E Edwards, Geeta K Swamy, Chad A Grotegut
OBJECTIVE: We examined the effects of magnesium sulfate on non-neurologic neonatal outcomes with respect to cord blood magnesium level. STUDY DESIGN: We conducted a secondary analysis of the Maternal-Fetal Medicine Units Beneficial Effects of Antenatal Magnesium (MFMU BEAM) trial comparing the upper and lower quintiles of cord blood magnesium level. Outcomes included cerebral palsy (CP), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and assessments of mental and motor disability...
February 12, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29430623/perinatal-outcome-of-monochorionic-and-dichorionic-twins-after-spontaneous-and-assisted-conception-a-retrospective-cohort-study
#9
Karien E A Hack, Marijn E M S Vereycken, Helen L Torrance, Corine Koopman-Esseboom, Jan B Derks
INTRODUCTIO: The aim of this study was to compare pregnancy outcomes in twin pregnancies after ACand spontaneous conception, according to chorionicity. MATERIAL AND METHODS: Retrospective cohort study of 1305 twin pregnancies between 1995 and 2015. All spontaneous (n=731) and assisted conception conceived twin pregnancies (n=574) with antenatal care and delivery in University Medical Center Utrecht, The Netherlands, a tertiary obstetric care center were studied according to chorionicity...
February 11, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29429468/-research-advances-in-necrotizing-enterocolitis-in-neonates
#10
Xin Gan, Juan Li
Necrotizing enterocolitis (NEC) is a catastrophic disease caused by a variety of factors in neonates, especially preterm infants. Severe NEC has a high fatality rate, and most survivors may face short- and long-term adverse prognosis. Risk factors for NEC include preterm birth, non-breastfeeding, microbial abnormalities in the digestive tract, and ischemia-reperfusion injury. High-resolution abdominal ultrasound helps with the early diagnosis of NEC. The preventive measures for NEC include protecting the intestinal mucosa through nutritional intervention, interfering with intestinal injury signals, changing intestinal microflora, and performing early minimal enteral nutrition...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29429456/-role-of-donor-human-milk-feeding-in-preventing-nosocomial-infection-in-very-low-birth-weight-infants
#11
Hong-Juan Bi, Jing Xu, Qiu-Fen Wei
OBJECTIVE: To investigate the role of donor human milk in the prevention of nosocomial infection in very low birth weight infants. MeETHODS: A total of 105 hospitalized preterm infants with a very low birth weight were enrolled. They were classified into mother's own milk feeding group, donor human milk feeding group, and preterm formula feeding group, with 35 infants in each group. The three groups were compared in terms of incidence rates of nosocomial infection, necrotizing enterocolitis, and feeding intolerance, time to full enteral feeding, and early growth indices...
February 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29428742/short-communication-roles-of-outer-membrane-protein-w-ompw-on-survival-and-biofilm-formation-of-cronobacter-sakazakii-under-neomycin-sulfate-stress
#12
Yingwang Ye, Na Ling, Jina Gao, Maofeng Zhang, Xiyan Zhang, Liaowang Tong, Dexin Ou, Yaping Wang, Jumei Zhang, Qingping Wu
Cronobacter sakazakii is associated with severe infections including sepsis, neonatal meningitis, and necrotizing enterocolitis. Antibiotic resistance in Cronobacter species has been documented in recent years, but the genes involved in resistance in Cronobacter strains are poorly understood. In this study, we determined the role of outer membrane protein W (OmpW) on survival rates, morphologic changes, and biofilm formation between wild type (WT) and an OmpW mutant strain (ΔOmpW) under neomycin sulfate stress...
February 7, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29422156/expert-consensus-to-weight-an-adherence-score-for-audit-and-feedback-of-practices-that-prevent-necrotizing-enterocolitis-in-very-low-birth-weight-infants
#13
Sheila M Gephart, Christina Wyles, Jennifer Canvasser
OBJECTIVE: Necrotizing enterocolitis (NEC) is a catastrophic abdominal complication threatening the life of premature infants, but adoption of prevention and early recognition practices differs as do NEC rates in Neonatal Intensive Care Units (NICUs). The purpose of this research was to validate and weight an evidence-based adherence score (aka NEC-Zero Adherence Score) to prevent and foster timely recognition of NEC. STUDY DESIGN: An electronic Delphi (e-Delphi) approach was used to identify consensus...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29410545/placental-transfusion-in-preterm-neonates-of-30-33-weeks-gestation-a-randomized-controlled-trial
#14
Bikramjit Das, Venkataseshan Sundaram, William Tarnow-Mordi, Alpana Ghadge, Lakhbir Kaur Dhaliwal, Praveen Kumar
OBJECTIVES: To compare effect of placental transfusion by delayed cord clamping (DCC) or cord milking (CM) with early cord clamping (ECC) on a composite of mortality or abnormal neurological status at 40 weeks' post-menstrual age (PMA) and 24-30 months' chronological age in neonates of 30-33 weeks' gestation. STUDY DESIGN: Randomized, controlled trial. OUTCOMES: A composite of mortality or abnormal neurological status at 40 weeks PMA and survival free of neurodevelopmental abnormalities at 24-30 months' chronological age...
February 6, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29409620/necrotizing-enterocolitis-as-a-prognostic-factor-for-the-neurodevelopmental-outcome-of-preterm-infants-match-control-study-after-2years
#15
Antje Allendorf, Ruth Dewitz, Joy Weber, Shahrzad Bakthiar, Rolf Schloesser, Udo Rolle
PURPOSE: Necrotizing enterocolitis (NEC) in very low birth weight infants is a risk factor for developmental delay. To our knowledge, there are no studies published investigating the neurodevelopmental outcome of patients with NEC comparing surgically treated and conservatively treated patients versus match paired controls. The aim of this retrospective case control study was to measure the neurodevelopmental outcome of patients with NEC who were treated surgically or conservatively METHODS: All patients were identified, who have been diagnosed with NEC (ICD-10 code, P77) born between 2006 and 2013...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29405832/beyond-sepsis-staphylococcus-epidermidis-is-an-underestimated-but-significant-contributor-to-neonatal-morbidity
#16
Ying Dong, Christian P Speer, Kirsten Glaser
Staphylococcus epidermidis accounts for the majority of cases of neonatal sepsis. Moreover, it has been demonstrated to be associated with neonatal morbidities, such as bronchopulmonary dysplasia (BPD), white matter injury (WMI), necrotizing enterocolitis (NEC) and retinopathy of prematurity (ROP), which affect short-term and long-term neonatal outcome. Imbalanced inflammation has been considered to be a major underlying mechanism of each entity. Conventionally regarded as a harmless commensal on human skin, S...
February 6, 2018: Virulence
https://www.readbyqxmd.com/read/29402455/routine-supplementation-of-lactobacillus-rhamnosus-gg-and-risk-of-necrotizing-enterocolitis-in-very-low-birth-weight-infants
#17
Andrea F Kane, Anisha D Bhatia, Patricia W Denning, Andi L Shane, Ravi Mangal Patel
OBJECTIVE: To evaluate if routine supplementation of Lactobacillus rhamnosus GG ATCC 53103 (LGG) is associated with a decreased risk of necrotizing enterocolitis in very low birth weight (VLBW) infants. STUDY DESIGN: Retrospective observational cohort study of VLBW (<1500 g) infants at a single center from 2008 to 2016. LGG supplementation with Culturelle at a dose of 2.5 to 5 × 109 CFU/day began in 2014. We used multivariable logistic regression to evaluate the association between LGG supplementation and necrotizing enterocolitis (modified Bell stage IIA or greater), after adjusting for potential confounders...
February 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29402454/postoperative-enteral-nutrition-guidelines-reduce-the-risk-of-intestinal-failure-associated-liver-disease-in-surgical-infants
#18
Darla R Shores, Samuel M Alaish, Susan W Aucott, Janine E Bullard, Courtney Haney, Heidi Tymann, Bareng A S Nonyane, Kathleen B Schwarz
OBJECTIVE: To assess the effectiveness of postoperative feeding guidelines in reducing the incidence and severity of intestinal failure-associated liver disease (IFALD) among infants. STUDY DESIGN: Two cohorts of infants <6 months old undergoing intestinal surgery were compared: preguideline (retrospective data from 2007 to 2013; n = 83) and postguideline (prospective data from 2013 to 2016; n = 81). The guidelines included greater initial enteral nutrition volumes of 20 mL/kg/d and daily feeding advancement if tolerated...
February 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29399120/significance-of-dynamic-evolution-of-tnf-%C3%AE-il-6-and-intestinal-fatty-acid-binding-protein-levels-in-neonatal-necrotizing-enterocolitis
#19
Zhaohui Li, Lei Sheng
To study the significance of dynamic evolution of serum tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and intestinal fatty acid-binding protein (I-FABP) levels in neonatal necrotizing enterocolitis (NEC). A total of 45 NEC child patients, 45 non-NEC child patients and 45 healthy newborns were enrolled. After the day age, weight, gestational week and delivery mode were matched, the serum TNF-α, IL-6 and I-FABP levels at 6, 24 and 72 h after admission were measured via ELISA method, and their correlations with prognosis were analyzed...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29393025/-intrauterine-necrotizing-enterocolitis-in-premature-newborns
#20
Peter Bill-Juul Ladegaard, Lars Rasmussen, Gitte Zachariassen
Necrotizing enterocolitis (NEC) is a severe disorder associated with increased morbidity and mortality when found in premature infants. This report is about two cases of NEC initiated in utero but without a prior knowledge to neither parents nor health professionals. Both cases had similar courses postnatally, which included abdominal distension and nutritional problems. The surgical findings: case I was a classical NEC in 20-25 cm of distal ileum, and case II was a 1.5-cm necrosis with perforation in proximal ileum...
January 29, 2018: Ugeskrift for Laeger
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