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enterocolitis necrotizing

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https://www.readbyqxmd.com/read/29679047/a-quality-improvement-initiative-to-reduce-necrotizing-enterocolitis-across-hospital-systems
#1
Amy T Nathan, Laura Ward, Kurt Schibler, Laurel Moyer, Andrew South, Heather C Kaplan
OBJECTIVE: Necrotizing enterocolitis (NEC) is a devastating intestinal disease in premature infants. Local rates of NEC were unacceptably high. We hypothesized that utilizing quality improvement methodology to standardize care and apply evidence-based practices would reduce our rate of NEC. STUDY DESIGN: A multidisciplinary team used the model for improvement to prioritize interventions. Three neonatal intensive care units (NICUs) developed a standardized feeding protocol for very low birth weight (VLBW) infants, and employed strategies to increase the use of human milk, maximize intestinal perfusion, and promote a healthy microbiome...
April 20, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29679046/impact-of-antenatal-corticosteroids-in-preterm-neonates-based-on-maternal-body-mass-index
#2
Maheer Faden, Sarah D McDonald, Prakeshkumar S Shah, Amit Mukerji
OBJECTIVE: Impact of antenatal corticosteroid (ACS) in context of maternal body mass index (BMI) as it relates to neonatal outcomes remains unclear. We sought to evaluate effects of ACS on clinical outcomes of preterm infants based on maternal BMI. METHODS: We performed a retrospective cohort study among neonates 23-33 weeks' GA at a tertiary neonatal intensive care unit from 2011 to 2015. Outcomes of neonates exposed to any ACS and pre-pregnancy maternal BMI ≥ 25 (N = 491) were compared with maternal BMI < 25 (N = 484)...
April 20, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29669357/oxygenation-of-the-immature-infant-a-commentary-and-recommendations-for-oxygen-saturation-targets-and-alarm-limits
#3
Ola Didrik Saugstad
BACKGROUND: For 70 years, there has been a search for the optimal oxygenation of premature infants. In spite of the lack of evidence, guidelines have successively reduced oxygenation targets during these years. OBJECTIVES: (1) To present a summary of previously published meta-analyses of 5 randomized studies (NeOProM) which tested a low (85-89%) versus a high (91-95%) oxygen saturation target the first weeks after birth on outcome of immature newborn infants. (2) To present international recommendations for oxygenation the first weeks after birth...
April 18, 2018: Neonatology
https://www.readbyqxmd.com/read/29661576/treatment-of-experimental-necrotizing-enterocolitis-with-stem-cell-derived-exosomes
#4
Christopher J McCulloh, Jacob K Olson, Yijie Wang, Yu Zhou, Natalie Huibregtse Tengberg, Shivani Deshpande, Gail E Besner
PURPOSE: Necrotizing enterocolitis (NEC) remains a devastating disease in premature infants. We previously showed that four stem cell (SC) types equivalently improve experimental NEC. Exosomes are intercellular nanovesicles containing RNA, miRNA, DNA, and protein. Because SC therapy faces challenges, our aim was to determine if the beneficial effects of SC are achievable with cell-free exosomes. METHODS: Exosomes from four SC types were compared: (1) amniotic fluid-derived mesenchymal SC (AF-MSC); (2) bone marrow-derived MSC (BM-MSC); (3) amniotic fluid-derived neural SC (AF-NSC); and (4) neonatal enteric NSC (E-NSC)...
March 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29658462/-research-advances-in-immune-tolerance-of-allogeneic-cell-transplantation-in-preterm-infants
#5
Can Lyu, Yi Qu, De-Zhi Mu
Preterm infants are a special group, and related severe neurological, respiratory, and digestive disorders have high disability/fatality rates. Allogeneic cell transplantation may be an effective method for the prevention and treatment of these diseases. At present, animal studies have been conducted for allogeneic cell transplantation in the treatment of hypoxic-ischemic encephalopathy, bronchopulmonary dysplasia, and necrotizing enterocolitis. The main difficulty of this technique is graft-versus-host reaction (GVHR), and successful induction of immune tolerance needs to be achieved in order to solve this problem...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29657735/necrotizing-enterocolitis-associated-with-clostridium-butyricum-in-a-japanese-man
#6
Yukio Sato, Dai Kujirai, Katsura Emoto, Toshiaki Yagami, Taketo Yamada, Manabu Izumi, Masaki Ano, Kenichi Kase, Kenji Kobayashi
Case: Necrotizing enterocolitis (NEC) caused by Clostridium butyricum is common in neonates; however, a case of NEC in adults has not been previously reported. An 84-year-old Japanese man developed C. butyricum -related NEC during hospitalization for treatment of stab wounds to the left side of the neck and lower abdomen, without organ damage, and concomitant pneumonia. Outcome: The patient developed acute onset of emesis accompanied by shock during his admission; partial resection of the small intestine was carried out due to necrosis...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29648878/protective-effect-of-lactobacillus-reuteri-dsm-17938-against-experimental-necrotizing-enterocolitis-is-mediated-by-toll-like-receptor-2
#7
Thomas K Hoang, Baokun He, Ting Wang, Dat Q Tran, Jon Marc Rhoads, Yuying Liu
Lactobacillus reuteri DSM 17938 (LR 17938) has been shown to reduce the incidence and severity of necrotizing enterocolitis (NEC). It is unclear if preventing NEC by LR 17938 is mediated by toll-like receptor 2 (TLR2), which is known to mediate pro-inflammatory responses to bacterial cell wall components. NEC was induced in newborn TLR2-/- or WT mice by the combination of gavage-feeding cow milk-based formula and exposure to hypoxia and cold stress. Treatment groups were administered formula supplemented with LR 17938 or placebo (MRS media)...
April 12, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29648506/systemic-equid-alphaherpesvirus-9-in-a-grant-s-zebra
#8
Robert B Moeller, Beate Crossley, Arlena Pipkin, Yanqiu Li, Udeni B R Balasuriya
A 2-y-old female Grant's zebra ( Equus quagga [ burchellii] boehmi) was presented with a clinical history of depression, anorexia, and weakness of 1-wk duration. Postmortem examination identified ulcers on the tongue and palate; a large abscess adjacent to the larynx; left lung consolidation; mild swelling, darkening, and congestion of the liver with accentuation of the lobular pattern; and edema and congestion of the distal small and large intestines. Histologic examination identified necrotizing bronchopneumonia, necrotizing hepatitis, nephritis, and enterocolitis...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29644455/neonatal-independent-predictors-of-severe-nec
#9
Miriam Duci, Francesco Fascetti-Leon, Marta Erculiani, Elena Priante, Maria Elena Cavicchiolo, Giovanna Verlato, Piergiorgio Gamba
PURPOSE: Necrotizing enterocolitis (NEC) is a severe neonatal disease. The present study aimed to identify factors predisposing the development of severe forms of NEC. METHODS: This retrospective study examined NEC patients in a single centre between 2002 and 2015. Data concerning clinical characteristics, therapeutic management as well as short-term outcomes were collected. We compared the patients receiving successful medical treatment and those requiring surgical intervention...
April 11, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29628209/outcomes-in-patients-with-short-bowel-syndrome-after-autologous-intestinal-reconstruction-does-etiology-matter
#10
Federica Pederiva, Alberto Sgrò, Riccardo Coletta, Basem Khalil, Antonino Morabito
BACKGROUND: Short bowel syndrome (SBS) is the most common cause of intestinal failure in children. Many factors have been investigated in an attempt to define which parameters influence most survival and ability to wean off parenteral nutrition (PN). The aim of this study was to investigate if aetiology of SBS affects the outcomes in paediatric patients treated with autologous gastrointestinal reconstructive surgery. METHODS: All children with SBS who underwent autologous gastrointestinal reconstructive surgery between 2002 and 2012 were retrospectively reviewed and outcome measures were recorded...
March 12, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29628208/complex-gastroschisis-clinical-spectrum-and-neonatal-outcomes-at-a-referral-center
#11
Pablo Laje, Maria V Fraga, William H Peranteau, Holly L Hedrick, Nahla Khalek, Juliana S Gebb, Julie S Moldenhauer, Mark P Johnson, Alan W Flake, N Scott Adzick
AIM OF THE STUDY: To evaluate the outcomes of neonates with complex gastroschisis (GC), and correlate outcomes with each type of complication. METHODS: Retrospective review of patients with complex GC owing to prenatal and/or postnatal abdominal complications; 2008-2016. Primary outcomes: time to discontinue parenteral nutrition (off-PN), length of stay (LOS) and neonatal survival. MAIN RESULTS: We treated 58 patients with complex gastroschisis owing to abdominal complications, which were: intestinal necrosis at birth (n=9), intestinal atresia (n=16), medical necrotizing enterocolitis (NEC) (n=15), surgical NEC (n=1), in utero volvulus (n=1), vanishing gastroschisis (n=2), severe intestinal dysmotility (n=1), delayed abdominal closure (n=3), abdominal compartment syndrome (n=2) and hiatal hernia/severe gastroesophageal reflux disease (GERD; n=11)...
March 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29627178/growth-morbidity-in-extremely-low-birth-weight-survivors-of-necrotizing-enterocolitis-at-discharge-and-two-year-follow-up
#12
Charles R Hong, Brenna S Fullerton, Charles E Mercier, Kate A Morrow, Erika M Edwards, Karla R Ferrelli, Roger F Soll, Biren P Modi, Jeffrey D Horbar, Tom Jaksic
PURPOSE: The purpose of this study was to examine postnatal growth outcomes and predictors of growth failure at 18-24months corrected age among extremely low birth weight (ELBW) survivors of necrotizing enterocolitis (NEC) compared to survivors without NEC. METHODS: Data were collected prospectively on ELBW (22-27weeks gestation or 401-1000g birth weight) infants born 2000-2013 at 46 centers participating in the Vermont Oxford Network follow-up project. Severe growth failure was defined as <3rd percentile weight-for-age...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29624430/do-transfusions-cause-necrotizing-enterocolitis-evidence-and-potential-mechanisms
#13
Edmund F LaGamma
No abstract text is available yet for this article.
April 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29623733/necrotizing-enterocolitis-with-systemic-gas-embolism
#14
Claire Anne Therese M Hemedez, Füsun Gündoğan
No abstract text is available yet for this article.
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29622398/time-to-reintroduction-of-feeding-in-infants-with-nonsurgical-necrotizing-enterocolitis
#15
Chase A Arbra, Andra Oprisan, Dulaney A Wilson, Rita M Ryan, Aaron P Lesher
BACKGROUND: For infants with necrotizing enterocolitis (NEC) treated nonoperatively, no consensus exists on the optimal fasting period prior to reintroducing feeds after NEC. We report our experience with early (<7days) and late (≥7days) refeeding in this population. METHODS: A chart review of infants with NEC born between 2006 and 2016 was performed. Data elements include demographics, comorbidities, day of diagnosis, Bell's stage, recurrence, strictures, length of stay and mortality, and were grouped into early and late refeeding...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29621942/intestinal-lesions-in-dogs-with-acute-hemorrhagic-diarrhea-syndrome-associated-with-netf-positive-clostridium-perfringens-type-a
#16
Miriam Leipig-Rudolph, Kathrin Busch, John F Prescott, Iman Mehdizadeh Gohari, Christian M Leutenegger, Walter Hermanns, Georg Wolf, Katrin Hartmann, Jutta Verspohl, Stefan Unterer
Acute hemorrhagic diarrhea syndrome (AHDS), formerly named canine hemorrhagic gastroenteritis, is one of the most common causes of acute hemorrhagic diarrhea in dogs, and is characterized by acute onset of diarrhea, vomiting, and hemoconcentration. To date, histologic examinations have been limited to postmortem specimens of only a few dogs with AHDS. Thus, the aim of our study was to describe in detail the distribution, character, and grade of microscopic lesions, and to investigate the etiology of AHDS. Our study comprised 10 dogs with AHDS and 9 control dogs of various breeds, age, and sex...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29618412/loss-of-endothelial-nitric-oxide-synthase-exacerbates-intestinal-and-lung-injury-in-experimental-necrotizing-enterocolitis
#17
Natalie A Drucker, Amanda R Jensen, Jan P Te Winkel, Michael J Ferkowicz, Troy A Markel
BACKGROUND: Necrotizing enterocolitis (NEC) continues to be a devastating condition among preterm infants. Nitric oxide, which is synthesized in the intestine by endothelial nitric oxide synthase (eNOS), acts as a potent vasodilator and antioxidant within the mesentery and may play a role in prevention of NEC. We hypothesized that loss of endothelial nitric oxide would worsen both intestinal and associated lung injury and increase local and systemic inflammation during experimental NEC...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29618272/does-fortification-of-pasteurized-donor-human-milk-increase-the-incidence-of-necrotizing-enterocolitis-among-preterm-neonates-a-randomized-controlled-trial
#18
Bethou Adhisivam, Dilesh Kohat, Vasanthan Tanigasalam, Vishnu Bhat, Nishad Plakkal, C Palanivel
OBJECTIVE: To compare the effect of fortified pasteurized donor human milk (PDHM) versus unfortified PDHM on the incidence of necrotizing enterocolitis (NEC) and immediate outcome among preterm neonates. METHODS: This randomized controlled trial (RCT) conducted in a tertiary care teaching hospital, south India included 80 healthy preterm neonates randomized to two groups (Group A and B). Neonates in Group A and B were fed with fortified PDHM and unfortified PDHM respectively...
April 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29617042/use-of-a-gastroschisis-feeding-guideline-to-improve-standardization-of-care-and-patient-outcomes-at-an-urban-children-s-hospital
#19
R Colby Passaro, Kate B Savoie, Eunice Y Huang
BACKGROUND: This study examined clinical outcomes associated with the use of a gastroschisis-specific (GS) feeding advancement guideline. METHODS: We performed a retrospective study of all simple gastroschisis babies (N = 65) treated between June 2009June 2015. We compared patients treated on a postintestinal surgery guideline using either a 1-day (1D) or 3-day (3D) feeding advancement from August 2009-August 2013 with infants treated on a GS guideline from September 2013-June 2015...
April 4, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29614567/-predictive-factors-of-mortality-in-extremely-preterm-infants
#20
L Lin, M C Fang, H Jiang, M L Zhu, S Q Chen, Z L Lin
Objective: To investigate the predictive factors of mortality in extremely preterm infants. Methods: The retrospective case-control study was accomplished in the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University. A total of 268 extremely preterm infants seen from January 1, 1999 to December 31, 2015 were divided into survival group (192 cases) and death group (76 cases). The potential predictive factors of mortality were identified by univariate analysis, and then analyzed by multivariate unconditional Logistic regression analysis...
April 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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