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https://www.readbyqxmd.com/read/30020347/patient-ventilator-asynchrony
#1
Marcelo Alcantara Holanda, Renata Dos Santos Vasconcelos, Juliana Carvalho Ferreira, Bruno Valle Pinheiro
Patient-v entilator asynchrony (PVA) is a mismatch between the patient, regarding time, flow, volume, or pressure demands of the patient respiratory system, and the ventilator, which supplies such demands, during mechanical ventilation (MV). It is a common phenomenon, with incidence rates ranging from 10% to 85%. PVA might be due to factors related to the patient, to the ventilator, or both. The most common PVA types are those related to triggering, such as ineffective effort, auto-triggering, and double triggering; those related to premature or delayed cycling; and those related to insufficient or excessive flow...
July 16, 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/30020201/risk-factors-and-main-indications-for-palivizumab-prophylaxis-in-a-second-season-population-results-from-the-german-synagis%C3%A2-registry-2009-2016
#2
Arne Simon, Susanne Gehrmann, Gudrun Wagenpfeil, Stefan Wagenpfeil
BACKGROUND: Following national recommendations, palivizumab is administered in Germany to high-risk infants to prevent hospitalizations related to respiratory syncytial virus (RSV) infection. Limited data are available to characterize those children who receive palivizumab in 2 consecutive RSV seasons. METHODS: This was a comparative analysis of data from a postmarketing observational study (German SYNAGIS™ Registry) detailing RSV-related risk factors and main indications for palivizumab in 920 children who received at ≥1 palivizumab injection in a second season between 2010-2016 (second season population; SSP)...
July 16, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/30020157/intraoperative-neurophysiological-monitoring-in-neuroanesthesia
#3
Rogean R Nunes, Carlos D A Bersot, João G Garritano
PURPOSE OF REVIEW: The purpose of this review is to highlight the importance of making informed choices of anesthetics and evaluating the impact of depth of anesthesia, hemodynamic status and other factors capable of interfering with signal capture during intraoperative neurophysiological monitoring (IONM). RECENT FINDINGS: Over the last decades, neuromonitoring has advanced considerably, allowing for insights into neurological function during anesthesia and making it possible to assess intraoperative consciousness and neural integrity in real time...
July 16, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/30020144/comparison-of-a-novel-clinical-score-to-estimate-the-risk-of-residual-neuromuscular-block-prediction-score-and-the-last-train-of-four-count-documented-in-the-electronic-anaesthesia-record-a-retrospective-cohort-study-of-electronic-data-on-file
#4
Maíra I Rudolph, Pauline Y Ng, Hao Deng, Flora T Scheffenbichler, Stephanie D Grabitz, Jonathan P Wanderer, Timothy T Houle, Matthias Eikermann
BACKGROUND: Residual neuromuscular block (rNMB) after surgery is not difficult to identify if proper neuromuscular monitoring is used, but many clinicians do not use quantitative neuromuscular monitoring. OBJECTIVE: The aim of this study was to develop a REsidual neuromuscular block Prediction Score (REPS) to predict postoperative rNMB and compare the predictive accuracy of the prediction score with train-of-four count (TOFC) measurement at the end of a surgical case...
July 16, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/30019482/quantitative-analysis-of-surface-electromyography-for-pediatric-neuromuscular-disorders
#5
Mana Higashihara, Masahiro Sonoo, Akihiko Ishiyama, Yu Nagashima, Kohji Matsumoto, Haruo Uesugi, Madoka Mori-Yoshimura, Miho Murata, Shigeo Murayama, Hirofumi Komaki
INTRODUCTION: Needle EMG has been an important diagnostic tool, although discomfort may limit its use in some children. We investigated the diagnostic utility of the Clustering Index (CI) method, a quantitative analysis for surface EMG (SEMG), in children. METHODS: SEMG was recorded from the tibialis anterior muscle. Discriminant analysis between neurogenic and myopathic patients was performed for whole epochs using the CI and area values. RESULTS: Forty-five children (29 myopathies, 16 neurogenic disorders; age 9...
July 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30019451/the-effect-of-intrapulmonary-percussive-ventilation-in-pediatric-patients-a-systematic-review
#6
Eline Lauwers, Kris Ides, Kim Van Hoorenbeeck, Stijn Verhulst
BACKGROUND: Intrapulmonary percussive ventilation (IPV) is frequently used in clinical practice to enhance sputum evacuation and lung recruitment. However, the evidence in different respiratory pathologies, especially in children, is still lacking. This systematic review aims to enlist the effectiveness of IPV as an airway clearance technique in pediatric patients. DATA SOURCES: A systematic literature search was performed in PubMed, Web of Science, and the Cochrane Library databases...
July 18, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/30019308/the-limb-girdle-muscular-dystrophies-is-treatment-on-the-horizon
#7
REVIEW
Mary Lynn Chu, Ellen Moran
There has been an ever-expanding list of the Limb-Girdle Muscular Dystrophies (LGMD). There are currently 8 subtypes of autosomal dominant (AD) and 26 subtypes of autosomal recessive (AR) LGMD. Despite continued research efforts to conquer this group of genetic neuromuscular disease, patients continue to be treated symptomatically with the aim of prevention or addressing complications. Mouse models have been helpful in clarifying disease pathogenesis as well as strategizing pathways for treatment. Discoveries in translational research as well as molecular therapeutic approaches have kept clinicians optimistic that more promising clinical trials will lead the way to finding the cure for these devastating disorders...
July 17, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/30018940/ipsilateral-proprioceptive-neuromuscular-facilitation-patterns-improve-overflow-and-reduce-foot-drop-in-patients-with-demyelinating-polyneuropathy
#8
Carolina S Nakada, Paula C Meningroni, Ana Claudia Silva Ferreira, Luciana Hata, Amanda C Fuzaro, Wilson Marques Júnior, João Eduardo de Araujo
The purpose of this study was to evaluate the response of the tibialis anterior muscle (TAm) using surface electromyography in patients with Charcot-Marie-Tooth disease (CMT-IA), after ipsilateral proprioceptive neuromuscular patterns (PNF). Thirteen CMT-IA patients (both sexes) were treated twice a week, for 5 weeks, with bilateral PNF pattern, four times per treatment. During the execution of the patterns, we recorded the bilateral activation of the TAm in root mean square (RMS). We used the Student paired t -test for the first and last treatments, P -value set at <0...
June 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/30018563/neuromuscular-control-and-performance-differences-associated-with-gender-and-obesity-in-fatiguing-tasks-performed-by-older-adults
#9
Xu Duan, Joohyun Rhee, Ranjana K Mehta, Divya Srinivasan
Obesity rates in the geriatric population have emerged as a serious health concern in recent decades. Yet, obesity-related differences in neuromuscular performance and motor control during fatiguing tasks, and how they are modified by gender, specifically among older adults, are still largely unexplored. The first aim of this study was to understand obesity and gender-related differences in endurance time among older adults. Motor variability has been linked with inter-individual differences in the rate of fatigue development, and as potentially revealing underlying mechanisms of neuromuscular control...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30018531/muscle-strength-and-neuromuscular-control-in-low-back-pain-elite-athletes-versus-general-population
#10
María Moreno Catalá, Arno Schroll, Gunnar Laube, Adamantios Arampatzis
The purpose of the study was to investigate the athletic-based specificity of muscle strength and neuromuscular control of spine stability in chronic non-specific low-back pain (LBP). Thirty elite athletes and 29 age-matched non-athletes with (15 athletes and 15 non-athletes) and without LBP (15 athletes and 14 non-athletes) participated in the study. Muscle strength was measured during maximal isometric trunk flexion and trunk extension contractions. The neuromuscular control of spine stability was analyzed by determining trunk stiffness, trunk damping, and onset times of the lumbar and thoracic erector spinae muscles after sudden perturbations (quick release experiments) as well as maximum Lyapunov exponents (local dynamic stability) using non-linear time series analysis of repetitive lifting movements...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30018422/a-novel-slc9a1-mutation-causes-cerebellar-ataxia
#11
Kazuhiro Iwama, Hitoshi Osaka, Takahiro Ikeda, Satomi Mitsuhashi, Satoko Miyatake, Atsushi Takata, Noriko Miyake, Shuichi Ito, Takeshi Mizuguchi, Naomichi Matsumoto
The mammalian Na+ /H+ exchanger isoform one (NHE1), encoded by Solute Carrier Family 9, member 1 (SLC9A1), consists of 12 membrane domains and a cytosolic C-terminal domain. NHE1 plays an important role in maintaining intracellular pH homeostasis by exchanging one intracellular proton for one extracellular sodium ion. Mice with a homozygous null mutation in Slc9a1 (Nhe1) exhibited ataxia, recurrent seizures, and selective neuronal cell death. In humans, three unrelated patients have been reported: a patient with a homozygous missense mutation in SLC9A1, c...
July 17, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/30017491/review-of-pelvic-and-perineal-neuromuscular-fatigue-evaluation-and-impact-on-therapeutic-strategies
#12
REVIEW
Maëlys Teng, Florian Kervinio, Mirella Moutounaïck, Gabriel Miget, Audrey Charlanes, Camille Chesnel, Frédérique Le Breton, Gérard Amarenco
BACKGROUND: Pelvic floor fatigue is known by its clinical consequences (fecal incontinence, stress urinary incontinence, pelvic organ prolapse), but there are still few studies on the subject. OBJECTIVE: This article presents an overview of the current knowledge of pelvic and perineal fatigue, focusing on its assessment and consequences in terms of evaluation and therapeutic strategies, to propose an evaluation that could be routinely performed. METHODS: We performed a systematic review of the literature in MEDLINE via PubMed and Cochrane Library databases by using the keywords pelvic floor, muscular fatigue, physiopathology, stress urinary incontinence, pelvic organ prolapse, fecal incontinence, physical activity, and pelvic rehabilitation...
July 11, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/30017464/active-versus-local-vibration-warm-up-effects-on-knee-extensors-stiffness-and-neuromuscular-performance-of-healthy-young-males
#13
Robin Souron, Alessandro Zambelli, Loïc Espeit, Thibault Besson, Darryl J Cochrane, Thomas Lapole
OBJECTIVES: To compare the effects of local-vibration and active warm-up on knee extensors muscle stiffness and neuromuscular performance. DESIGN: Experimental crossover study. METHODS: Thirteen participants performed three 15-min warm-up protocols of control (CON), active (ACT) and local-vibration (LV) in separate testing session. Passive stiffness of vastus lateralis (VL) and vastus medialis (VM) by shear wave elastography and neuromuscular performance were assessed before and 2-min after each condition...
July 10, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/30017412/a-novel-staged-wrist-sensorimotor-rehabilitation-program-for-a-patient-with-triangular-fibrocartilage-complex-injury-a-case-report
#14
Zhiqing Chen
STUDY DESIGN: Case report. INTRODUCTION: Studies have highlighted the sensory innervations and stabilizing role of forearm muscles on wrist joint and implications to wrist sensorimotor rehabilitation. This case explored the novel incorporation of dart-throwing motion and proprioceptive neuromuscular facilitation in wrist sensorimotor rehabilitation. PURPOSE OF THE STUDY: To describe and evaluate a staged wrist sensorimotor rehabilitation program for a patient with triangular fibrocartilage complex (TFCC) injury...
July 12, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/30017359/a-new-case-expanding-the-mutation-and-phenotype-spectrum-of-tmem5-related-alpha-dystroglycanopathy
#15
Ann-Kathrin Zaum, Konstantinos Kolokotronis, Wolfram Kress, Hans-Hilmar Goebel, Simone Rost, Jürgen Seeger
Dystroglycanopathies are a diverse group of neuromuscular disorders caused by aberrant glycosylation of alpha-dystroglycan. TMEM5 is one of many glycosyltransferases recently described to be associated with alpha-dystroglycanopathies. We report the case of a 15-year-old boy suffering from a congenital muscular dystrophy with elevated serum creatine kinase levels and an almost complete absence of alpha-dystroglycan in muscle biopsy. The clinical course was milder than any previously reported case and did not include brain or eye defects...
June 20, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/30017354/mitofusin-2-regulates-axonal-transport-of-calpastatin-to-prevent-neuromuscular-synaptic-elimination-in-skeletal-muscles
#16
Luwen Wang, Ju Gao, Jingyi Liu, Sandra L Siedlak, Sandy Torres, Hisashi Fujioka, Mikayla L Huntley, Yinfei Jiang, Haiyan Ji, Tingxiang Yan, Micah Harland, Pichet Termsarasab, Sophia Zeng, Zhen Jiang, Jingjing Liang, George Perry, Charles Hoppel, Cheng Zhang, Hu Li, Xinglong Wang
Skeletal muscles undergo atrophy in response to diseases and aging. Here we report that mitofusin 2 (Mfn2) acts as a dominant suppressor of neuromuscular synaptic loss to preserve skeletal muscles. Mfn2 is reduced in spinal cords of transgenic SOD1G93A and aged mice. Through preserving neuromuscular synapses, increasing neuronal Mfn2 prevents skeletal muscle wasting in both SOD1G93A and aged mice, whereas deletion of neuronal Mfn2 produces neuromuscular synaptic dysfunction and skeletal muscle atrophy. Neuromuscular synaptic loss after sciatic nerve transection can also be alleviated by Mfn2...
July 2, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/30016203/corticospinal-changes-induced-by-fatiguing-eccentric-versus-concentric-exercise
#17
Yoann M Garnier, Christos Paizis, Romuald Lepers
The present study assessed neuromuscular and corticospinal changes during and after a fatiguing submaximal exercise of the knee extensors in different modes of muscle contraction. Twelve subjects performed two knee extensors exercises in a concentric or eccentric mode, at the same torque and with a similar total impulse. Exercises consisted of 10 sets of 10 repetitions at an intensity of 80% of the maximal voluntary isometric contraction torque (MVIC). MVIC, maximal voluntary activation level (VAL) and responses of electrically evoked contractions of the knee extensors were assessed before and after exercise...
July 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/30016189/larger-strength-losses-and-muscle-activation-deficits-in-plantar-flexors-induced-by-backward-downhill-in-reference-to-distance-matched-forward-uphill-treadmill-walk
#18
Olivier Girard, Sébastien Banzet, Nathalie Koulmann, Mounir Chennaoui, Catherine Drogou, Hakim Chalabi, Sébastien Racinais
We tested the hypothesis that backward downhill walking (eccentric component) impairs both voluntary activation and muscle contractile properties in the plantar flexors and delays recovery as compared to a gradient and distance-matched uphill walk. Fourteen males performed two 30-min walking exercises (velocity: 1 m/ s; grade: 25%; load: 12% of body weight), one downhill (DW) and one uphill (UP), in a counterbalanced order, separated by 6 weeks. Neuromuscular test sessions were performed before, after, 24-, 48- and 72-h post-exercise, including motor nerve stimulations during brief (5 s) and sustained (1 min) maximal isometric voluntary contractions of the plantar flexors...
July 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/30015672/malignant-hyperthermia-still-an-issue-for-neuromuscular-diseases
#19
Bram De Wel, Kristl G Claeys
PURPOSE OF REVIEW: We will give an overview of neuromuscular disorders that can be linked with malignant hyperthermia or malignant hyperthermia-like reactions, and suggest an appropriate approach to interpret the risks. RECENT FINDINGS: An increasing number of neuromuscular phenotypes have been linked to malignant hyperthermia susceptibility (MHS). This is for an important part due to the highly variable phenotype associated with mutations in the ryanodine receptor 1 gene (RYR1), the gene most frequently associated with MHS...
July 14, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/30015204/is-neuromuscular-inhibition-detectable-in-elite-footballers-during-the-nordic-hamstring-exercise
#20
Lincoln Blandford, Nicola Theis, Ingrid Charvet, Ryan Mahaffey
BACKGROUND: The presence of neuromuscular inhibition following injury may explain the high incidence of biceps femoris injury recurrence in elite (soccer) footballers. This phenomenon may be detectable in elite players during the Nordic hamstring exercise. Thus, the first purpose of this study was to assess biceps femoris muscle activation during this exercise in players with hamstring injury history. Additionally, following injury, observed increases in synergistic muscle activation may represent a protective mechanism to the presence of neuromuscular inhibition...
July 10, 2018: Clinical Biomechanics
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