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Lars Larsson, Hans Degens, Meishan Li, Leonardo Salviati, Young Il Lee, Wesley Thompson, James L Kirkland, Marco Sandri
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility, diminishes quality of life, and can lead to fall-related injuries, which require costly hospitalization and extended rehabilitation. This review focuses on the aging-related structural changes and mechanisms at cellular and subcellular levels underlying changes in the individual motor unit: specifically, the perikaryon of the α-motoneuron, its neuromuscular junction(s), and the muscle fibers that it innervates. Loss of muscle mass with aging, which is largely due to the progressive loss of motoneurons, is associated with reduced muscle fiber number and size...
January 1, 2019: Physiological Reviews
Andreas Apostolidis, Vassilis Mougios, Ilias Smilios, Johanna Rodosthenous, Marios Hadjicharalambous
PURPOSE: Inconsistent results among studies examining the effects of caffeine on exercise performance are potentially due to inter-individual variability in biological responses to caffeine ingestion. The aims, therefore, of the present study were to identify high and low caffeine responders and compare the influence of caffeine on exercise performance and biological responses between groups during a simulated soccer-game protocol on treadmill. METHODS: Well-trained soccer-players were distinguished as high (n = 11) and low (n = 9) caffeine responders based on resting blood pressure, plasma glycerol, non-esterified fatty acid and epinephrine responses to caffeine...
November 14, 2018: International Journal of Sports Physiology and Performance
Joel Garrett, Stuart R Graham, Roger G Eston, Darren J Burgess, Lachlan J Garrett, John Jakeman, Kevin Norton
PURPOSE: To compare the sensitivity of a submaximal run test (SRT) with a countermovement jump (CMJ) test to provide an alternate method of measuring neuromuscular fatigue (NMF) in high performance sport. METHODS: 23 professional and semi-professional Australian rules football (ARF) players, performed a SRT and CMJ test, pre-match, 48- and 96-hours post-match. Variables from accelerometers recorded during the SRT were; player load 1D up (PL1Dup ) (vertical vector); player load 1D side (PL1Dside ) (medio-lateral vector); and player load 1D forward (PL1Dfwd ) (anterio-posterior vector)...
November 14, 2018: International Journal of Sports Physiology and Performance
Sergio Jiménez-Rubio, Archit Navandar, Jesús Rivilla-García, Victor Paredes-Hernández
CONTEXT: Despite the presence of various injury prevention programs, the rate of hamstring injuries and re-injuries is increasing, warranting the need for a soccer-specific rehabilitation program. OBJECTIVE: To develop and validate a new, functional on-field program for the rehabilitation and readaptation after a hamstring strain injury through a panel of experts; and determine its usefulness through the application of this program in professional soccer players...
November 14, 2018: Journal of Sport Rehabilitation
Mo Zhao, Nika Maani, James J Dowling
Dynamin 2 (DNM2) belongs to a family of large GTPases that are well known for mediating membrane fission by oligomerizing at the neck of membrane invaginations. Autosomal dominant mutations in the ubiquitously expressed DNM2 cause 2 discrete neuromuscular diseases: autosomal dominant centronuclear myopathy (ADCNM) and dominant intermediate Charcot-Marie-Tooth neuropathy (CMT). CNM and CMT mutations may affect DNM2 in distinct manners: CNM mutations may cause protein hyperactivity with elevated GTPase and fission activities, while CMT mutations could impair DNM2 lipid binding and activity...
November 13, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Herbert Djiambou-Nganjeu
Background and Objectives: Hepatic encephalopathy (HE) research has long been impeded by the vague definition of this disabling complication of liver failure. This article provides an overview of the etiology and impact of HE on neuromuscular functions as well as its role in the development of infections and anemia. Materials and Methods: This was a descriptive study conducted in 36 patients with HE. Close monitoring of these patients was done by checking on several parameters...
September 2018: Journal of Translational Internal Medicine
Lorena Del Amo Castrillo, Matthieu Lacombe, Aurélien Boré, Isabelle Vaugier, Line Falaize, David Orlikowski, Hélène Prigent, Frédéric Lofaso
BACKGROUND: Breath-stacking, which consists of taking 2 or more consecutive ventilator insufflations without exhaling, is a noninvasive and inexpensive cough-assistance technique for patients with neuromuscular disease. Volumetric cough mode (VCM) is a recently introduced ventilator mode consisting of a programmable intermittent deep breath equal to a set percentage of the baseline tidal volume. Here, our objective was to compare VCM to breath-stacking during volume-control continuous mandatory ventilation in subjects on long-term noninvasive mechanical ventilation at home...
November 13, 2018: Respiratory Care
Naoyuki Ochiai, Yukei Matsumoto, Yuki Hara, Yasumasa Nishiura, Shinji Murai
BACKGROUND: In infant poliomyelitis or poliomyelitis-like paresis, there has been no means of treating residual paralysis and the policy has been to wait until an affected infant has grown sufficiently to enable tendon transfer or arthrodesis. However, recent reports have described relatively good results for early surgical intervention in the form of nerve transfer. METHODS: In a 4-year and 6-month-old child we transferred a partial ulnar nerve for elbow flexor reconstruction even 3 years and 10 months after the onset of poliomyelitis-like palsy and also transferred partial accessory and radial nerves for shoulder function restoration 6 months after the first operation...
November 10, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Víctor López Del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo
No abstract text is available yet for this article.
November 10, 2018: Biochimica et biophysica acta. Molecular basis of disease
Amanda L Ager, Jean-Sébastien Roy, France Gamache, Luc J Hébert
Introduction: Shoulder pain, a leading reason to consult a physician or physiotherapist, continues to be a challenge to rehabilitate, particularly with a military population. A rotator cuff (RC) tendinopathy, the most important source of shoulder pain, is one of the leading reasons for sick leave or a discharge from active military service. Research encourages the use of exercise prescription for the management of a RC tendinopathy, however the ideal method of delivery (group setting versus one-on-one) remains uncertain...
November 13, 2018: Military Medicine
Marisol Sampedro Castañeda, Edmar Zanoteli, Renata S Scalco, Vinicius Scaramuzzi, Vitor Marques Caldas, Umbertina Conti Reed, Andre Macedo Serafim da Silva, Benjamin O'Callaghan, Rahul Phadke, Enrico Bugiardini, Richa Sud, Samuel McCall, Michael G Hanna, Hanne Poulsen, Roope Männikkö, Emma Matthews
Hypokalaemic periodic paralysis is a rare genetic neuromuscular disease characterized by episodes of skeletal muscle paralysis associated with low serum potassium. Muscle fibre inexcitability during attacks of paralysis is due to an aberrant depolarizing leak current through mutant voltage sensing domains of either the sarcolemmal voltage-gated calcium or sodium channel. We report a child with hypokalaemic periodic paralysis and CNS involvement, including seizures, but without mutations in the known periodic paralysis genes...
November 12, 2018: Brain: a Journal of Neurology
Nia J Jones, Nicola Ivins, Vicky Ebdon, Susan Hagelstein, Keith G Harding
The geko™ is a disposable neuromuscular electrostimulation (NMES) device intended to increase blood circulation and promote wound healing in a range of lower limb conditions. The purpose of this case series was to evaluate the therapeutic effect of the geko device on wound healing outcomes over an 8-week period. Thirty patients with non-healing wounds (≥ 12-week duration) of either venous leg ulceration (VLU), mixed leg ulceration (MLU) or diabetic foot ulceration aetiology were recruited from a local outpatient wound clinic in the South Wales area...
November 8, 2018: British Journal of Nursing: BJN
Rozina Bhimani, Frank Medina, Lisa Carney-Anderson
Recognizing crucial distinctions between muscle tightness, spasticity, and clonus. ABSTRACT: Neuromuscular disorders are complex, difficult both to differentiate and to manage. Yet nurses, who encounter a symptomatically diverse neuromuscular patient population in various practice settings, are expected to be well versed in managing the variable associated symptoms of these disorders. Here the authors discuss how to assess such neuromuscular conditions as muscle tightness, spasticity, and clonus; the pathophysiology underlying each; and the available recommended treatments, an understanding of which is necessary for successful symptom management and clear provider-patient communication...
November 6, 2018: American Journal of Nursing
Ghilas Boussaïd, Carole Vuillerot, Joana Pisco Domingos, Antoine Dany, Enzo Ricci, Laurent Servais, François Constant Boyer
No abstract text is available yet for this article.
November 2018: Médecine Sciences: M/S
Christian Réveillère
No abstract text is available yet for this article.
November 2018: Médecine Sciences: M/S
Aurélien Perrin, Philippe Latour, Vincent Procaccio, Claude Jardel, Mathieu Cérino, Gisèle Bonne, Emmanuelle Salort-Campana, J Andoni Urtizberea, Jean Pouget, Martin Krahn, Mireille Cossée
No abstract text is available yet for this article.
November 2018: Médecine Sciences: M/S
Annemie Smeets, Bart Malfait, Bart Dingenen, Mark A Robinson, Jos Vanrenterghem, Koen Peers, Stefaan Nijs, Styn Vereecken, Filip Staes, Sabine Verschueren
BACKGROUND: There is limited evidence on neuromuscular risk factors for anterior cruciate ligament (ACL) injuries, with most work mainly focusing on hamstrings and quadriceps muscle strength. This prospective pilot study explored if neuromuscular activation patterns of the quadriceps and hamstrings during a drop vertical jump influence ACL injury risk. METHODS: Forty-six female athletes performed a drop vertical jump at baseline. Injuries were monitored throughout a one-year follow-up...
November 8, 2018: Knee
Maria Gabriela O Fernandes, Vanessa F Santos, Natália Martins, Maria C Sucena, Madalena M Passos, Maria Manuel Marques, Adriana M Magalhães, António Bugalho
BACKGROUND: Different anesthetic protocols may influence endobronchial ultrasound-guided needle aspiration (EBUS-TBNA) outcomes, patient comfort, and even safety. In this study, two anesthesia techniques were assessed and compared for EBUS-TBNA. METHODS: A prospective, multicenter study was carried out. Patients were allocated to Group 1 (general anesthesia with neuromuscular blockade and controlled ventilation) and Group 2 (intravenous sedation). EBUS-TBNA accuracy was the primary outcome...
November 8, 2018: Journal of Clinical Medicine
T I Grushina
The author selected the set of ICF (International Classification of Functioning, Disability and Health) categories selected for breast cancer patients presenting with the major late complications of the surgical treatment, such as upper limp lymphedema, pain syndrome, and mobility limitation in the shoulder joint on the side of the intervention. The problems associated with each component of ICF are described including the body functions - 26 categories, body structures - 15, activities and participation - 49, environmental factors - 31 categories...
2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Rafael Lima Kons, Jorge Nelson Da Silva Junior, Bruno Follmer, Luiz Felipe Guarise Katcipis, Ramdane Almansba, Daniele Detanico
Uchi-komi Fitness Test (UFT) is a specific judo test that evaluates physiological fitness of judo athletes in similar conditions to judo matches. Neuromuscular parameters obtained by generic and judo-specific tests would aid to get more information about its criterion validity. This study aimed to analyse the relationship between UFT and shoulder external (PTEX ) and internal (PTINT ) rotation torque, handgrip strength (HGS) and vertical jumps (VJs) performance. The relationship between UFT and Judogi grip strength test (JGST) was also investigated...
November 9, 2018: Sports Biomechanics
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