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Md Arifuzzaman, Akira Ito, Kazushi Ikeda, Yoshinori Kawabe, Masamichi Kamihira
Tissue-engineered skeletal muscle constructs have attracted significant attention in the field of regenerative medicine. However, the contractile force produced by tissue-engineered skeletal muscle constructs is not comparable to natural skeletal muscle tissues. To improve the contractile force generation of tissue-engineered skeletal muscle constructs, we investigated the effects of co-culturing C2C12 myoblasts with PC12 neural cells for the fabrication of skeletal muscle tissue constructs. Immunocytochemical analysis revealed differentiation of C2C12 myotubes and outgrowth of PC12 neurites toward the aligned myotubes with improved βIII-tubulin-positive neuronal area, suggesting enhanced neural differentiation of PC12 cells...
September 15, 2018: Tissue Engineering. Part A
Jae Min Kim, Tae Gun Shin, Sung Yeon Hwang, Hee Yoon, Won Chul Cha, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong
PURPOSE: Postintubation hypotension (PIH) is an adverse event associated with poor outcomes in emergency department (ED) endotracheal intubation. This study aimed to evaluate the association between sedative dose adjustment and PIH during emergency airway management. We also investigated the impact of patient and procedural factors on the incidence of PIH. MATERIALS AND METHODS: This was a single-center, retrospective study that used a prospectively collected registry of airway management performed at the ED from April 2014 to February 2017...
September 12, 2018: American Journal of Emergency Medicine
Seong Chin
Although a wheel is an ideal method for transportation and the invention of the spoke wheel made a wheel lighter and swifter, a wheel cannot function well on slanted or rough surfaces; these are common in the natural environment. Further, the load support of the wheel is limited to a point of the whole wheel in contact with the ground. Then, we humans may be using the legs as a part of spoke wheel and place our legs and feet on the ground alternatively to support the body weight while the gravitational torque makes the center of mass (COM) rotate around the hip joint when proper stiffness and balance is made...
November 2018: Medical Hypotheses
David A Wilson, Nadine Booysen, Paolo Dainese, Markus O Heller, Maria Stokes, Martin B Warner
Hip and groin pain is common in footballers and altering movement patterns can reduce symptoms. Observational tests of movement control are thought to identify abnormal movement patterns, but their accuracy needs yet to be confirmed by comparison with an objective measure. To assess the accuracy, using 3D motion analysis, of observational movement control tests and their ability to detect changes, and document changes in symptoms following a neuromuscular control exercise programme in an ex-footballer with hip and groin pain...
November 2018: Medical Hypotheses
Juan P Cata, Javier D Lasala, Wendell Williams, Gabriel E Mena
Myasthenia gravis (MG) is a rare neuromuscular disorder characterized by skeletal muscle weakness. Patients with MG who have thymoma and thymic hyperplasia have indications for thymectomy. The perioperative care of patients with MG scheduled for thymus resection should be focused on optimizing their neuromuscular function, identifying factors related to postoperative mechanical ventilation, and avoiding of triggers associated with myasthenic or cholinergic crisis. Minimally invasive surgical techniques, use of regional analgesia, and avoidance or judicious administration of neuromuscular blocking drugs (NMBs) is recommended during the perioperative period...
July 29, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Ana C Panhan, Mauro Gonçalves, Giovana D Eltz, Marina M Villalba, Adalgiso C Cardozo, Fausto Bérzin
BACKGROUND: Pilates exercises help stabilize the vertebral segments by recruiting the abdominal and spinal muscles. Pilates training may increase joint stability and improve neuromuscular efficiency (NME). OBJECTIVE: This study aimed to evaluate NME of the multifidus (MU) muscle through electromyography (EMG) analysis and torque test, applied to practitioners and non-practitioners of Pilates. METHODS: Participants included thirty women: Pilates practitioners (n = 15) and non-practitioners (n = 15)...
October 2018: Complementary Therapies in Medicine
T Ito, F Matsui, K Fujimoto, S Matsuyama, K Yazawa, F Matsumoto, K Shimada
INTRODUCTION: Torsion of an undescended testis (UDT) associated with cerebral palsy (CP) and neuromuscular disease (NMD) is an uncommon condition that is not well recognized by primary care physicians or healthcare providers. OBJECTIVE: The objective of this study was to highlight the clinical importance of torsion of a UDT in children with CP and NMD. MATERIALS AND METHODS: Eleven children with testicular torsion of a UDT operated on at the study institute between 1991 and 2015 were identified...
August 23, 2018: Journal of Pediatric Urology
Yuan Qiao, Menglin Cong, Jianmin Li, Hao Li, Zhenzhong Li
BACKGROUND: The formation of intrafusal muscle (IM) fibers and their contact with afferent proprioceptive axons is critical for construction, function, and maintenance of the stretch reflex. Many factors affect the formation of IM fibers. Finding new factors and mechanisms of IM fiber formation is essential for the reconstruction of stretch reflex arc after injury. METHODS: We established a coculture system of organotypic dorsal root ganglion (DRG) explants and dissociated skeletal muscle (SKM) cells...
September 15, 2018: Skeletal Muscle
Sarianna Sipilä, Anna Tirkkonen, Tuomo Hänninen, Pia Laukkanen, Markku Alen, Roger A Fielding, Miia Kivipelto, Katja Kokko, Jenni Kulmala, Taina Rantanen, Sanna E Sihvonen, Elina Sillanpää, Anna Stigsdotter-Neely, Timo Törmäkangas
BACKGROUND: Safe and stable walking is a complex process involving the interaction of neuromuscular, sensory and cognitive functions. As physical and cognitive functions deteriorate with ageing, training of both functions may have more beneficial effects on walking and falls prevention than either alone. This article describes the study design, recruitment strategies and interventions of the PASSWORD study investigating whether a combination of physical and cognitive training (PTCT) has greater effects on walking speed, dual-task cost in walking speed, fall incidence and executive functions compared to physical training (PT) alone among 70-85-year-old community-dwelling sedentary or at most moderately physically active men and women...
September 15, 2018: BMC Geriatrics
Yusuke Yamashita, Toshifumi Takasusuki, Yoshiyuki Kimura, Makoto Komatsuzaki, Shigeki Yamaguchi
INTRODUCTION: Reversal of non-depolarizing neuromuscular blocking agent neostigmine is associated with QT prolongation under general anesthesia. To clarify the effects of neostigmine and sugammadex on hemodynamic status, the QT interval and QT dispersion after reversal of neuromuscular blockade were evaluated with a 12-lead electrocardiogram. To exclude QT prolongation due to sevoflurane, the present study was performed under propofol anesthesia. METHODS: After receiving approval from the ethics committee of Dokkyo Medical University Hospital, 40 patients with American Society of Anesthesiologists physical status I or II were randomly allocated to group N (n = 20) or group S (n = 20)...
September 14, 2018: Cardiology and Therapy
Sonia Messina, Gian Luca Vita
INTRODUCTION: Duchenne muscular dystrophy (DMD) is a devastating, progressive neuromuscular disorder for which there is no cure. As the dystrophin gene is located on the X chromosome, DMD occurs predominately in males. DMD is caused by a lack of functional dystrophin protein resulting from mutations in the 2.2-Mb DMD gene, whichdisrupts the reading frame. Care considerations for DMD advocate a coordinated, multidisciplinary approach to the management of DMD in order to optimize management of the primary manifestations of DMD as well as any secondary complications that may arise...
September 14, 2018: Neurological Sciences
Martijn Boon, Christian H Martini, Leon P H J Aarts, Albert Dahan
INTRODUCTION: Surgical rating scales (SRSs) enable the surgeon to uniformly quantify surgical working conditions. They are increasingly used as a primary outcome in studies evaluating the effect of anaesthesia or surgery-related interventions on the quality of the surgical work field. SRSs are especially used in laparoscopic surgery due to a renewed interest in deep neuromuscular block. There are however no guidelines regarding the uniform use of SRS and the uniform reporting of results...
September 14, 2018: Surgical Endoscopy
Adrien Moreau, Pascal Gosselin-Badaroudine, Aurélie Mercier, Bettina Burger, Dagmar I Keller, Mohamed Chahine
Dilated cardiomyopathy (DCM) is a structural heart disease that causes dilatation of cardiac chambers and impairs cardiac contractility. The SCN5A gene encodes Nav 1.5, the predominant cardiac sodium channel alpha subunit. SCN5A mutations have been identified in patients with arrhythmic disorders associated with DCM. The characterization of Nav 1.5 mutations located in the voltage sensor domain (VSD) and associated with DCM revealed divergent biophysical defects that do not fully explain the pathologies observed in these patients...
September 14, 2018: Scientific Reports
Irineu Loturco, Chris Bishop, Rodrigo Ramirez-Campillo, Felipe Romano, Mateus Alves, Lucas A Pereira, Michael McGuigan
The purpose of this case study was to examine the effects of a resistance-training program based on the optimum power loads (OPL) method on neuromuscular performance of Olympic boxing athletes during preparation for the Rio-2016 Olympic Games. Twelve elite amateur boxers from the Brazilian National Olympic Team participated in this study. Athletes were assessed at four time-points, over two consecutive competitive seasons. In the first season (considered as "control period"), the athletes executed a non-controlled strength-power training program for 10 weeks...
September 13, 2018: Sports
Jessica D Thompson, Prudence Plummer, Jason R Franz
BACKGROUND: Inspired by a reliance on visual feedback for movement control in older age, optical flow perturbations provide a unique opportunity to study the neuromuscular mechanisms involved in walking balance control, including aging and falls history effects on the response to environmental balance challenges. Specifically, antagonist leg muscle coactivation, which increases with age during walking, is considered a neuromuscular defense against age-associated deficits in balance control...
September 8, 2018: Clinical Biomechanics
James B Caress, Michael S Cartwright
No abstract text is available yet for this article.
September 14, 2018: Muscle & Nerve
Mark E Nunnally
No abstract text is available yet for this article.
October 2018: Critical Care Medicine
Vincenzo Todisco, Giovanni Cirillo, Rocco Capuano, Alessandro d'Ambrosio, Gioacchino Tedeschi, Antonio Gallo
Objective: To report the clinical features and the neurophysiological approach of a patient with Lambert-Eaton myasthenic syndrome (LEMS), highlighting the diagnostic role of the stimulated single fiber electromyography (sSFEMG). Case report: A 60-year-old woman presenting with the LEMS triad (proximal and axial weakness, autonomic dysfunction and areflexia) was evaluated by neurophysiological tests (electroneuromyography, repetitive stimulation test (TSR), voluntary and stimulated SFEMG)...
2018: Clinical Neurophysiology Practice
Philip B Adebayo, Funmilola T Taiwo, Mayowa O Owolabi
Objective: This study aims to assess the frequency and indication for electrodiagnostic referrals as well as to summarize the findings from the procedure at a neurorehabilitation center in Ibadan, Nigeria. Methods: This is a retrospective cross-sectional study. Data from referrals to Blossom Medical Centre/World Federation for Neurorehabilitation (BMC/WFNR) center, Ibadan, Nigeria, from April 2014 to December 2016 were collated and analyzed. Results: Sixty referrals were received during the period of evaluation...
2018: Clinical Neurophysiology Practice
Mohammad Saeidi, Rosa Alikhani, Ahmad Hormati, Seyed Mehdi Sabouri, Reza Aminnejad
Masseter muscle rigidity is a known complication of drugs such as succinylcholine and volatile agents. However, muscle rigidity is an uncommon complication of propofol. We report the case of a 56-year-old ASA-PS class I woman refereeing for colonoscopy due to chronic constipation under deep intravenous sedation. She suffered masseter spasm after the injection of propofol. Masseter spasm should not be considered limited to special drug groups. In any case of difficult mouth opening, masseter spasm should be kept in mind and deepening of anesthesia or complete blockade of neuromuscular junction should be considered by the use of non-depolarizing muscle relaxants...
June 2018: Anesthesiology and Pain Medicine
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