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https://www.readbyqxmd.com/read/19559476/nifurtimox-eflornithine-combination-therapy-for-second-stage-african-trypanosoma-brucei-gambiense-trypanosomiasis-a-multicentre-randomised-phase-iii-non-inferiority-trial
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RANDOMIZED CONTROLLED TRIAL
Gerardo Priotto, Serena Kasparian, Wilfried Mutombo, Daniel Ngouama, Sara Ghorashian, Ute Arnold, Salah Ghabri, Elisabeth Baudin, Vincent Buard, Serge Kazadi-Kyanza, M├ędard Ilunga, Willy Mutangala, Gabriele Pohlig, Caecilia Schmid, Unni Karunakara, Els Torreele, Victor Kande
BACKGROUND: Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for patients with second-stage disease are toxic, ineffective, or impractical. We assessed the efficacy and safety of nifurtimox-eflornithine combination therapy (NECT) for second-stage disease compared with the standard eflornithine regimen. METHODS: A multicentre, randomised, open-label, active control, phase III, non-inferiority trial was done at four HAT treatment centres in the Republic of the Congo and the Democratic Republic of the Congo...
July 4, 2009: Lancet
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