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https://www.readbyqxmd.com/read/29678711/healthcare-associated-infections-after-subarachnoid-hemorrhage
#1
Yasser B Abulhasan, Najayeb Alabdulraheem, Ian Schiller, Susan P Rachel, Nandini Dendukuri, Mark R Angle, Charles Frenette
OBJECTIVE: Healthcare-associated infections (HAIs) after subarachnoid hemorrhage (SAH) are prevalent; however, data describing epidemiology of infection is limited. This study reports incidence rates, risk factors and the resulting SAH patient-related outcomes. METHODS: We studied the incidence of ICU-acquired HAIs over a 6-year period. We used Bayesian Model Averaging to identify risk factors associated with an increased risk of HAIs, particularly urinary tract infections (UTI), pneumonia and ventriculostomy-associated infections (VAI)...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678598/the-benefits-of-defining-snacks
#2
Julie M Hess, Joanne L Slavin
Whether eating a "snack" is considered a beneficial or detrimental behavior is largely based on how "snack" is defined. The term "snack food" tends to connote energy-dense, nutrient-poor foods high in nutrients to limit (sugar, sodium, and/or saturated fat) like cakes, cookies, chips and other salty snacks, and sugar-sweetened beverages. Eating a "snack food" is often conflated with eating a "snack," however, leading to an overall perception of snacks as a dietary negative...
April 17, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29675755/new-445-nm-blue-laser-for-laryngeal-surgery-combines-photoangiolytic-and-cutting-properties
#3
Markus M Hess, Susanne Fleischer, Marcel Ernstberger
BACKGROUND: Photoangiolytic lasers have broadened the surgical armamentarium for many phonosurgical interventions. However, the pulse dye laser and potassium titanyl phosphate (KTP) laser have technical drawbacks and a smaller spectrum of indications. METHODS AND RESULTS: The new 445 nm wavelength laser, the so-called 'blue laser', proves to show tissue effects comparable to the KTP laser and is also capable of treating subepithelial vessels due to its photoangiolytic properties, it can coagulate and carbonize at higher energy levels, and can be used via glass fibers in non-contact and contact mode for in-office procedures...
April 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29675720/initial-misdiagnosis-of-aneurysmal-subarachnoid-hemorrhage-associating-factors-and-its-prognosis
#4
Se-Yang Oh, Yong Cheol Lim, Yu Shik Shim, Jihye Song, Sang Kyu Park, Sook Young Sim, Myeong Jin Kim, Yong Sam Shin, Joonho Chung
BACKGROUND: Predicting the fate of patients who are given a misdiagnosis of aneurysmal subarachnoid hemorrhage (aSAH) remains unclear. The purpose was to examine factors associated with initial misdiagnosis of aSAH and to investigate the impact of initial misdiagnosis of aSAH on clinical outcomes. METHODS: Between January 2007 and December 2015, medical records and radiographic data for 3118 consecutive patients with aSAH were reviewed. There were 33 patients who had been documented with an initial misdiagnosis of aSAH, and all met the following criteria: (1) failure to correctly identify aSAH upon initial presentation to health care professionals; and 2) subsequently documented aSAH after the initial misdiagnosis...
April 20, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29674745/publisher-correction-the-sea-lamprey-germline-genome-provides-insights-into-programmed-genome-rearrangement-and-vertebrate-evolution
#5
Jeramiah J Smith, Nataliya Timoshevskaya, Chengxi Ye, Carson Holt, Melissa C Keinath, Hugo J Parker, Malcolm E Cook, Jon E Hess, Shawn R Narum, Francesco Lamanna, Henrik Kaessmann, Vladimir A Timoshevskiy, Courtney K M Waterbury, Cody Saraceno, Leanne M Wiedemann, Sofia M C Robb, Carl Baker, Evan E Eichler, Dorit Hockman, Tatjana Sauka-Spengler, Mark Yandell, Robb Krumlauf, Greg Elgar, Chris T Amemiya
In the version of this article initially published, the present addresses for authors Dorit Hockman and Chris Amemiya were switched. The error has been corrected in the HTML and PDF versions of the article.
April 19, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29674324/indications-for-the-performance-of-intracranial-endovascular-neurointerventional-procedures-a-scientific-statement-from-the-american-heart-association
#6
REVIEW
Clifford J Eskey, Philip M Meyers, Thanh N Nguyen, Sameer A Ansari, Mahesh Jayaraman, Cameron G McDougall, J Kevin DeMarco, William A Gray, David C Hess, Randall T Higashida, Dilip K Pandey, Constantino Peña, Hermann C Schumacher
Intracranial endovascular interventions provide effective and minimally invasive treatment of a broad spectrum of diseases. This area of expertise has continued to gain both wider application and greater depth as new and better techniques are developed and as landmark clinical studies are performed to guide their use. Some of the greatest advances since the last American Heart Association scientific statement on this topic have been made in the treatment of ischemic stroke from large intracranial vessel occlusion, with more effective devices and large randomized clinical trials showing striking therapeutic benefit...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29673274/drug-wastage-and-costs-to-the-healthcare-system-in-the-care-of-patients-with-non-small-cell-lung-cancer-in-the-united-states
#7
Lisa M Hess, Zhanglin Lin Cui, Xiaohong Ivy Li, Ana B Oton, Scott Shortenhaus, Ian A Watson
BACKGROUND: Lung cancer is one of the most prevalent cancers in the United States. This study was designed to evaluate the actual drug wastage and cost to the healthcare system using patient-level retrospective observational electronic medical record (EMR) data from a cohort of lung cancer patients in the United States (US). METHODS: Data from the Flatiron Health advanced non-small cell lung cancer (NSCLC) cohort was used for this study. Drug administered amount (in mg) was used to determine an optimal set of available vial sizes to minimize waste...
April 19, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29673018/combining-high-pressure-freezing-with-pre-embedding-immunogold-electron-microscopy-and-tomography
#8
Michael W Hess, Georg F Vogel, Teodor E Yordanov, Barbara Witting, Karin Gutleben, Hannes L Ebner, Mariana E G de Araujo, Przemyslaw Filipek, Lukas A Huber
Immunogold labeling of permeabilized whole-mount cells or thin-sectioned material is widely used for the subcellular localization of biomolecules at the high spatial resolution of electron microscopy (EM). Those approaches are well compatible with either three-dimensional (3D) reconstruction of organelle morphology and antigen distribution or with rapid cryofixation - but not easily with both at once. We describe here a specimen preparation and labeling protocol for animal cell cultures, which represents a novel blend of specifically adapted versions of established techniques...
April 19, 2018: Traffic
https://www.readbyqxmd.com/read/29672680/cognitive-correlates-of-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-in-mild-alzheimer-s-dementia
#9
Osama Sabri, Philipp M Meyer, Susanne Gräf, Swen Hesse, Stephan Wilke, Georg-Alexander Becker, Michael Rullmann, Marianne Patt, Julia Luthardt, Gudrun Wagenknecht, Alexander Hoepping, Rene Smits, Annegret Franke, Bernhard Sattler, Solveig Tiepolt, Steffen Fischer, Winnie Deuther-Conrad, Ulrich Hegerl, Henryk Barthel, Peter Schönknecht, Peter Brust
In early Alzheimer's dementia, there is a need for PET biomarkers of disease progression with close associations to cognitive dysfunction that may aid to predict further cognitive decline and neurodegeneration. Amyloid biomarkers are not suitable for that purpose. The α4β2 nicotinic acetylcholine receptors (α4β2-nAChRs) are widely abundant in the human brain. As neuromodulators they play an important role in cognitive functions such as attention, learning and memory. Post-mortem studies reported lower expression of α4β2-nAChRs in more advanced Alzheimer's dementia...
April 17, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29672396/compliant-workflow-design-engage-define-review-and-refine
#10
Cathy Thomas Hess
No abstract text is available yet for this article.
May 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29671589/linear-mgcp-2-vs-bent-cacp-2-london-dispersion-ligand-induced-charge-localizations-and-pseudo-pregostic-c-h%C3%A2-%C3%A2-%C3%A2-ca-interactions
#11
Rumpa Pal, Stefan Mebs, Ming W Shi, Dylan Jayatilaka, Joanna M Krzeszczakowska, Lorraine A Malaspina, Michal Wiecko, Peter Luger, Malte Hesse, Yu-Sheng Chen, Jens Beckmann, Simon Grabowsky
In the family of metallocenes, MgCp*2 (Cp* = pentamethylcyclopentadienyl) exhibits a regular linear sandwich structure, whereas CaCp*2 is bent in both the gas phase and solid state. Bending is typically observed for metal ions which possess a lone pair. Here, we investigate which electronic differences cause the bending in complexes lacking lone pairs at the metal atoms. The bent gas-phase geometry of CaCp*2 suggests that the bending must have an intramolecular origin. Geometry optimizations with and without dispersion effects/d-type polarization functions on MCp2 and MCp*2 gas-phase complexes (M = Ca, Mg) establish that attractive methyl···methyl London dispersion interactions play a decisive role in the bending in CaCp*2 ...
April 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29670145/the-mechanism-of-short-term-monocular-deprivation-is-not-simple-separate-effects-on-parallel-and-cross-oriented-dichoptic-masking
#12
Alex S Baldwin, Robert F Hess
Short-term deprivation of the input to one eye increases the strength of its influence on visual perception. This effect was first demonstrated using a binocular rivalry task. Incompatible stimuli are shown to the two eyes, and their competition for perceptual dominance is then measured. Further studies used a combination task, which measures the contribution of each eye to a fused percept. Both tasks show an effect of deprivation, but there have been inconsistencies between them. This suggests that the deprivation causes multiple effects...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670022/whole-genome-classification-and-phylogenetic-analyses-of-rotavirus-b-strains-from-the-united-states
#13
Frances K Shepherd, Diana Maria Herrera-Ibata, Elizabeth Porter, Nitipong Homwong, Richard Hesse, Jianfa Bai, Douglas G Marthaler
Rotaviruses (RVs) are a major etiological agent of acute viral gastroenteritis in humans and young animals, with rotavirus B (RVB) often detected in suckling and weaned pigs. Group A rotavirus classification is currently based on the two outer capsid proteins, VP7 and VP4, and the middle layer protein, VP6. Using RVB strains generated in this study and reference sequences from GenBank, pairwise identity frequency graphs and phylogenetic trees were constructed for the eleven gene segments of RVB to estimate the nucleotide identity cutoff values for different genotypes and determine the genotype diversity per gene segment...
April 18, 2018: Pathogens
https://www.readbyqxmd.com/read/29669809/two-distinct-sites-of-client-protein-interaction-with-the-chaperone-cpsrp43
#14
Camille McAvoy, Alex Siegel, Samantha Piszkiewicz, Emily Miaou, Mansen Yu, Thang Nguyen, Annie Moradian, Michael J Sweredoski, Sonja Hess, Shu-Ou Shan
Integral membrane proteins are prone to aggregation and misfolding in aqueous environments and therefore require binding by molecular chaperones during their biogenesis. Chloroplast signal recognition particle 43 (cpSRP43) is an ATP-independent chaperone required for the biogenesis of the most abundant class of membrane proteins, the light-harvesting chlorophyll a/b-binding proteins (LHCPs). Previous work has shown that cpSRP43 specifically recognizes an L18 loop sequence conserved among LHCP paralogs. However, how cpSRP43 protects the transmembrane domains (TMDs) of LHCP from aggregation was unclear...
April 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29669734/a-selective-extracellular-matrix-proteomics-approach-identifies-fibronectin-proteolysis-by-adamts16-and-its-impact-on-spheroid-morphogenesis
#15
Rahel Schnellmann, Ragna Sack, Daniel Hess, Douglas S Annis, Deane F Mosher, Suneel S Apte, Ruth Chiquet-Ehrismann
Secreted and cell-surface proteases are major mediators of extracellular matrix (ECM) turnover, but their mechanisms and regulatory impact are poorly understood. We developed a mass spectrometry approach using a cell-free ECM produced in vitro to identify fibronectin (FN) as a novel substrate of the secreted metalloprotease ADAMTS16. ADAMTS16 cleaves FN between its (I)5 and (I)6 modules, releasing the N-terminal 30 kDa heparin-binding domain essential for FN self-assembly. ADAMTS16 impairs FN fibrillogenesis as well as fibrillin-1 and tenascin-C assembly, thus inhibiting formation of a mature ECM by cultured fibroblasts...
April 18, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29668571/evaluating-for-pseudoprogression-in-colorectal-and-pancreatic-tumors-treated-with-immunotherapy
#16
Christine M Parseghian, Madhavi Patnana, Priya Bhosale, Kenneth R Hess, Ya-Chen Tina Shih, Bumyang Kim, Scott Kopetz, Michael J Overman, Gauri R Varadhachary, Milind Javle, Aung Naing, Sarina Piha-Paul, David Hong, Hung Le, Vivek Subbiah, Shubham Pant
Pseudoprogression has been observed in patients with various tumor types treated with immunotherapy. However, the frequency of pseudoprogression is unknown in gastrointestinal malignancies. Metastatic colorectal cancer (mCRC) and advanced pancreatic ductal adenocarcinoma (PDAC) patients who progressed on treatment with immunotherapy beyond RECIST version 1.1 criteria were analyzed. Degree of progression, tumor markers, time to progression, overall survival, Eastern Cooperative Oncology Group Performance Status (ECOG PS), and costs were analyzed for patients treated beyond progression (TBP) and not treated beyond progression...
April 17, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29664369/heartland-virus-and-hemophagocytic-lymphohistiocytosis-in-immunocompromised-patient-missouri-usa
#17
Abigail L Carlson, Daniel M Pastula, Amy J Lambert, J Erin Staples, Atis Muehlenbachs, George Turabelidze, Charles S Eby, Jesse Keller, Brian Hess, Richard S Buller, Gregory A Storch, Kathleen Byrnes, Louis Dehner, Nigar Kirmani, F Matthew Kuhlmann
Heartland virus is a suspected tickborne pathogen in the United States. We describe a case of hemophagocytic lymphohistiocytosis, then death, in an immunosuppressed elderly man in Missouri, USA, who was infected with Heartland virus.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29663366/a-genomic-copy-number-signature-predicts-radiation-exposure-in-post-chernobyl-breast-cancer
#18
Christina M Wilke, Herbert Braselmann, Julia Hess, Sergiy V Klymenko, Vadim V Chumak, Liubov M Zakhartseva, Elena V Bakhanova, Axel K Walch, Martin Selmansberger, Daniel Samaga, Peter Weber, Ludmila Schneider, Falko Fend, Hans C Bösmüller, Horst Zitzelsberger, Kristian Unger
Breast cancer is the second leading cause of cancer death among women worldwide and besides life-style, age and genetic risk factors, exposure to ionising radiation is known to increase the risk for breast cancer. Further, DNA copy number alterations (CNAs), which can result from radiation-induced double-strand breaks, are frequently occurring in breast cancer cells. We set out to identify a signature of CNAs discriminating breast cancers from radiation-exposed and non-exposed female patients. We analysed resected breast cancer tissues from 68 exposed female Chernobyl clean-up workers and evacuees and 68 matched non-exposed control patients for CNAs by array comparative genomic hybridisation analysis (aCGH)...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29662103/authority-psychotherapy-and-the-authority-of-the-therapist-in-the-religious-haredi-community
#19
Esther Hess
This article considers the meaning and significance of authority, and its relevance to the transference process, within the framework of psychotherapy in the orthodox Jewish (Haredi) community in Israel. In this community, deeply-rooted habits of obedience to the commandments of the Torah and the authority of the Rabbi are integral to maintaining an orthodox way of life. Clinical vignettes with Haredi patients are presented to illustrate the complexities that arise when both patient and therapist belong to the orthodox community, and highlight the authority-related issues that are central to the therapy...
April 16, 2018: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/29661243/effect-of-neoadjuvant-chemotherapy-regimen-on-relapse-free-survival-among-patients-with-breast-cancer-achieving-a-pathologic-complete-response-an-early-step-in-the-de-escalation-of-neoadjuvant-chemotherapy
#20
Anna Weiss, Sami I Bashour, Kenneth Hess, Alastair M Thompson, Nuhad K Ibrahim
BACKGROUND: Patients with breast cancer who have a pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) have improved survival. We hypothesize that once pCR has been achieved, there is no difference in subsequent postsurgical recurrence-free survival (RFS), whichever NACT regimen is used. METHODS: Data from patients with breast cancer who achieved pCR after NACT between 1996 and 2011 were reviewed. RFS was estimated by the Kaplan-Meier method, and differences between groups were assessed using log-rank testing...
April 16, 2018: Breast Cancer Research: BCR
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