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https://www.readbyqxmd.com/read/28239644/hla-dq-%C3%AE-1-alleles-associated-with-epstein-barr-virus-ebv-infectivity-and-ebv-gp42-binding-to-cells
#1
Qingxue Li, Wei Bu, Erin Gabriel, Fiona Aguilar, Yo Hoshino, Hiroko Miyadera, Christoph Hess, Ronald L Hornung, Amitava Roy, Jeffrey I Cohen
Epstein-Barr virus (EBV) infects B cells and ~95% of adults are infected. EBV glycoprotein gp42 is essential for entry of virus into B cells. EBV gp42 binds to the β1 chain of HLA-DQ, -DR, and -DP on B cells, and uses these molecules for infection. To investigate if certain HLA-DQ alleles are associated with EBV seronegativity, we recruited ~3,300 healthy adult blood donors, identified 106 EBV-seronegative individuals, and randomly selected a control group of EBV-seropositive donors from the donor pool. A larger than expected proportion of EBV-seronegative subjects were HLA-DQ β1 *04/*05 and *06/*06, and to a lesser extent, *02/*03, compared with the control group, while a larger than expected portion of EBV-seropositive persons were HLA-DQ β1 *02/*02...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28237778/genome-of-a-giant-bacteriophage-from-a-decaying-trichodesmium-bloom
#2
Ulrike Pfreundt, Dina Spungin, Shengwei Hou, Björn Voß, Ilana Berman-Frank, Wolfgang R Hess
De-novo assembly of a metagenomic dataset obtained from a decaying cyanobacterial Trichodesmium bloom from the New Caledonian lagoon resulted in a complete giant phage genome of 257,908bp, obtained independently with multiple assembly tools. Noteworthy, gammaproteobacteria were an abundant fraction in the sequenced samples. Mapping of the raw reads with 99% accuracy to the giant phage genome resulted in an average coverage of 262X. The closest sequenced relatives, albeit still distant, are the Pseudomonas phages PaBG from Lake Baikal and Lu11 isolated from a soil sample from the Philippines...
February 22, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28236182/endoscopic-management-of-a-low-grade-thalamic-glioma-a-safe-alternative-to-open-microsurgery
#3
Benjamin Brokinkel, Murat Yavuz, Nils Warneke, Angela Brentrup, Katharina Hess, Caroline Bleimüller, Johannes Wölfer, Walter Stummer
BACKGROUND: Despite considerable advances in preoperative and intraoperative imaging and neuronavigation, resection of thalamic gliomas remains challenging. Although both endoscopic biopsy and third ventriculostomy (ETV) for the treatment of secondary hydrocephalus are commonly performed, endoscopic resection of thalamic gliomas has been very sparsely described. METHOD: We report and illustrate the surgical procedure and patient's outcome after full endoscopic resection of a thalamic glioma and to discuss this approach as an alternative to open microsurgery...
February 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28235773/tlr10-suppresses-the-activation-and-differentiation-of-monocytes-with-effects-on-dc-mediated-adaptive-immune-responses
#4
Nicholas J Hess, Christopher Felicelli, Jennifer Grage, Richard I Tapping
TLRs are important pattern-recognition receptors involved in the activation of innate immune responses against foreign pathogens. TLR10 is the only TLR family member without a known ligand, signaling pathway, or clear cellular function. Previous work has shown that TLR10 suppresses proinflammatory cytokine production in response to TLR agonists in a mixed human mononuclear cell population. We report that TLR10 is preferentially expressed on monocytes and suppresses proinflammatory cytokine production resulting from either TLR or CD40 stimulation...
February 24, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28235521/aneurysmal-hemorrhage-in-a-pregnant-patient-with-coarctation-of-aorta-an-anesthetic-challenge
#5
G S Tomar, K Goyal, R Chandran, A Luthra, V Chauhan, N Kumar
A 25years old female patient with pregnancy of 16weeks (G2 P1), diagnosed to have distal anterior cerebral artery aneurysm (DACA) with Hunt & Hess grade I, subarachnoid hemorrhage (SAH) and coexisting atretic type of aortic coarctation posted for aneurysmal clipping under general anesthesia is a challenge to anesthesiologists in perioperative period. Hypertensive surges in a pregnant patient may result in rupture of aneurysms. Mortality in the mothers with CoA has been reported to be in the range of 0 to 9%...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28230563/implementation-of-an-early-mobility-pathway-in-neurointensive-care-unit-patients-with-external-ventricular-devices
#6
Megan Moyer, Bethany Young, Joseph Borst, William Pino, Marisa Hart, Jesse LoBreglio, Derek Zaleski, Isaira Leonor, David Kung, Michelle Smith, Eric Zager, M Sean Grady, Monisha Kumar
BACKGROUND: Patients with an external ventricular drain (EVD) may not be readily mobilized because of concerns of catheter dislodgment and/or inappropriate cerebrospinal fluid drainage. Delayed mobilization may result in longer hospital stays and an increased risk for complications related to immobility. We aimed to determine the safety, feasibility, and outcome of an EVD mobilization protocol in patients with subarachnoid hemorrhage (SAH). METHODS: A multidisciplinary group developed a formal algorithm for the mobilization of patients with SAH with EVDs...
February 23, 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28230420/age-related-effects-on-memory-for-social-stimuli-the-role-of-valence-arousal-and-emotional-responses
#7
Thomas M Hess, Lauren E Popham, Claire M Growney
: Background/Study Context: Previous research (Hess et al., 2013, Psychology and Aging, 28, 853-863) suggested that age-based positivity effects in memory were attenuated with social stimuli. This research examined the degree to which this generalized across arousal levels associated with social images. Variations in approach and avoidance responses to individual images were also examined, along with age differences in their relationship to memory performance. METHODS: In Experiment 1, young (22-43 years) and older (65-85 years) adults recalled positive and negative social scenes that were high or low in arousal...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28229179/erratum-to-non-metabolisable-insulin-glargine-does-not-promote-breast-cancer-growth-in-a-mouse-model-of-type-2-diabetes
#8
Emily J Gallagher, Zara Zelenko, Aviva Tobin-Hess, Ulrich Werner, Norbert Tennagels, Derek LeRoith
No abstract text is available yet for this article.
February 23, 2017: Diabetologia
https://www.readbyqxmd.com/read/28226957/inexpensive-bone-cement-substitute-for-vertebral-cement-augmentation-training
#9
Marianne Hollensteiner, Markus Samrykit, Michael Hess, David Fuerst, Benjamin Esterer, Andreas Schrempf, Marianne Hollensteiner, Markus Samrykit, Michael Hess, David Fuerst, Benjamin Esterer, Andreas Schrempf, Benjamin Esterer, Michael Hess, Markus Samrykit, Andreas Schrempf, Marianne Hollensteiner, David Fuerst
Vertebral compression fractures are treated surgically for approximately 25 years. In percutaneous cement augmentation techniques bone cement is applied to a fractured vertebra under fluoroscopic evidence to stabilize the bone fragments. Complications due to leakage of the low viscosity bone cement are reported in 5 to 15% of all routine cases. During the intraoperative application of bone cement surgeons rely on visiohaptic feedback and hence need to be familiar with the cement's rheology properties. Therefore, training is necessary...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225585/two-step-process-to-create-roll-off-superamphiphobic-paper-surfaces
#10
Lu Jiang, Zhenguan Tang, Rahmat M Clinton, Victor Breedveld, Dennis W Hess
Surface modification of cellulose-based paper which displays roll-off properties for water and oils (surface tension ≥ 23.8 mN·m-1) and good repellency towards n-heptane (20.1 mN·m-1) is reported. Droplets of water, diiodomethane, motor oil, hexadecane and decane all "bead up", i.e. exhibit high contact angles, and roll off the treated surface under the influence of gravity. Unlike widely used approaches that rely on the deposition of nanoparticles or electrospun nanofibers to create superamphiphobic surfaces, our method generates a hierarchical structure as an inherent property of the substrate and displays good adhesion between the film and substrate...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28223322/eta-receptors-blockade-by-activating-etb-receptors-increases-vascular-permeability-and-induces-exaggerated-fluid-retention
#11
Magali Vercauteren, Frederic Trensz, Anne Pasquali, Christophe Cattaneo, Daniel S Strasser, Patrick Hess, Marc Iglarz, Martine Clozel
Endothelin receptor antagonists have been associated with fluid retention. It has been suggested that, of the two endothelin receptor subtypes, ETB receptors should not be blocked, because of their involvement in natriuresis and diuresis. Surprisingly, clinical data suggest that ETA-selective antagonists pose a greater risk of fluid overload than dual antagonists. The purpose of this study was to evaluate the contribution of each endothelin receptor to fluid retention and vascular permeability in rats. Sitaxentan and ambrisentan as ETA-selective antagonists, bosentan and macitentan as dual antagonists were used as representatives of each class, respectively...
February 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28220009/new-horizons-for-nanophotonics
#12
Yuri S Kivshar, William L Barnes, Ortwin Hess, Nikolay Zheludev
No abstract text is available yet for this article.
March 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28219889/rapid-and-rigorous-il-17a-production-by-a-distinct-subpopulation-of-effector-memory-t-lymphocytes-constitutes-a-novel-mechanism-of-toxic-shock-syndrome-immunopathology
#13
Peter A Szabo, Ankur Goswami, Delfina M Mazzuca, Kyoungok Kim, David B O'Gorman, David A Hess, Ian D Welch, Howard A Young, Bhagirath Singh, John K McCormick, S M Mansour Haeryfar
Toxic shock syndrome (TSS) is caused by staphylococcal and streptococcal superantigens (SAgs) that provoke a swift hyperinflammatory response typified by a cytokine storm. The precipitous decline in the host's clinical status and the lack of targeted therapies for TSS emphasize the need to identify key players of the storm's initial wave. Using a humanized mouse model of TSS and human cells, we herein demonstrate that SAgs elicit in vitro and in vivo IL-17A responses within hours. SAg-triggered human IL-17A production was characterized by remarkably high mRNA stability for this cytokine...
February 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28218572/ictv-virus-taxonomy-profile-flaviviridae
#14
Peter Simmonds, Paul Becher, Jens Bukh, Ernest A Gould, Gregor Meyers, Tom Monath, Scott Muerhoff, Alexander Pletnev, Rebecca Rico-Hesse, Donald B Smith, Jack T Stapleton, Ictv Report Consortium
The Flaviviridae is a family of small enveloped viruses with RNA genomes of 9000-13 000 bases. Most infect mammals and birds. Many flaviviruses are host-specific and pathogenic, such as hepatitis C virus in the genus Hepacivirus. The majority of known members in the genus Flavivirus are arthropod borne, and many are important human and veterinary pathogens (e.g. yellow fever virus, dengue virus). This is a summary of the current International Committee on Taxonomy of Viruses (ICTV) report on the taxonomy of the Flaviviridae, which is available at www...
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28216677/control-of-terahertz-nonlinear-transmission-with-electrically-gated-graphene-metadevices
#15
Hyun Joo Choi, In Hyung Baek, Bong Joo Kang, Hyeon-Don Kim, Sang Soon Oh, Joachim M Hamm, Andreas Pusch, Jagang Park, Kanghee Lee, Jaehyeon Son, Young U K Jeong, Ortwin Hess, Fabian Rotermund, Bumki Min
Graphene, which is a two-dimensional crystal of carbon atoms arranged in a hexagonal lattice, has attracted a great amount of attention due to its outstanding mechanical, thermal and electronic properties. Moreover, graphene shows an exceptionally strong tunable light-matter interaction that depends on the Fermi level - a function of chemical doping and external gate voltage - and the electromagnetic resonance provided by intentionally engineered structures. In the optical regime, the nonlinearities of graphene originated from the Pauli blocking have already been exploited for mode-locking device applications in ultrafast laser technology, whereas nonlinearities in the terahertz regime, which arise from a reduction in conductivity due to carrier heating, have only recently been confirmed experimentally...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216473/five-year-results-from-a-prospective-multicentre-study-of-percutaneous-pulmonary-valve-implantation-demonstrate-sustained-removal-of-significant-pulmonary-regurgitation-improved-right-ventricular-outflow-tract-obstruction-and-improved-quality-of-life
#16
Alfred Hager, Stephan Schubert, Peter Ewert, Lars Søndergaard, Maarten Witsenburg, Paolo Guccione, Lee N Benson, José Suárez de Lezo, Te-Hsin Lung, John Hess, Andreas Eicken, Felix Berger
AIMS: Percutaneous pulmonary valve implantation (PPVI) is used to treat patients with dysfunctional pulmonary valve conduits. Short- and longer-term results from multiple trials have outlined haemodynamic improvements. Our aim was to report the long-term results, including quality of life, from a multicentre trial in Europe and Canada. METHODS AND RESULTS: From October 2007 to April 2009, 71 patients (24 female; median age 19.0 [IQR: 14.0 to 25.0] years) were enrolled in a prospective cohort study...
February 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28215100/targeting-baff-and-april-in-systemic-lupus-erythematosus-and-other-antibody-associated-diseases
#17
Eileen Samy, Stephen Wax, Bertrand Huard, Henry Hess, Pascal Schneider
The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand), are critical factors in the maintenance of the B cell pool and humoral immunity. In addition, BAFF and APRIL are involved in the pathogenesis of a number of human autoimmune diseases, with elevated levels of these cytokines detected in the sera of patients with systemic lupus erythematosus (SLE), IgA nephropathy, Sjögren's syndrome, and rheumatoid arthritis. As such, both molecules are rational targets for new therapies in B cell-driven autoimmune diseases, and several inhibitors of BAFF or BAFF and APRIL together have been investigated in clinical trials...
January 2, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28212182/what-s-new-in-obstetric-anesthesia-the-2016-gerard-w-ostheimer-lecture
#18
Philip E Hess
This special article presents potentially important trends and issues affecting the field of obstetric anesthesia drawn from publications in 2015. Both maternal mortality and morbidity in the United States have increased in recent years because, in part, of the changing demographics of the childbearing population. Pregnant women are older and have more pre-existing conditions and complex medical histories. Cardiovascular and noncardiovascular medical diseases now account for half of maternal deaths in the United States...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28211005/resequencing-and-annotation-of-the-nostoc-punctiforme-attc-29133-genome-facilitating-biofuel-and-high-value-chemical-production
#19
Luis E Moraes, Matthew J Blow, Erik R Hawley, Hailan Piao, Rita Kuo, Jennifer Chiniquy, Nicole Shapiro, Tanja Woyke, James G Fadel, Matthias Hess
Cyanobacteria have the potential to produce bulk and fine chemicals and members belonging to Nostoc sp. have received particular attention due to their relatively fast growth rate and the relative ease with which they can be harvested. Nostoc punctiforme is an aerobic, motile, Gram-negative, filamentous cyanobacterium that has been studied intensively to enhance our understanding of microbial carbon and nitrogen fixation. The genome of the type strain N. punctiforme ATCC 29133 was sequenced in 2001 and the scientific community has used these genome data extensively since then...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28210536/race-and-place-differences-in-patients-hospitalized-with-an-acute-coronary-syndrome-is-there-double-jeopardy-findings-from-trace-core
#20
Robert J Goldberg, Joel M Gore, David D McManus, Richard McManus, Mayra Tisminetzky, Darleen Lessard, Jerry H Gurwitz, David C Parish, Jeroan Allison, Connie Ng Hess, Tracy Wang, Catarina Kiefe
The objectives of this longitudinal study were to examine differences between whites and blacks, and across two geographical regions, in the socio-demographic, clinical, and psychosocial characteristics, hospital treatment practices, and post-discharge mortality for hospital survivors of an acute coronary syndrome (ACS). In this prospective cohort study, we performed in-person interviews and medical record abstractions for patients discharged from the hospital after an ACS at participating sites in Central Massachusetts and Central Georgia during 2011-2013...
June 2017: Preventive Medicine Reports
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