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Andor Molnár, Fanni Dublecz, László Pál, László Wágner, Claudia Hess, Michael Hess, Ferenc Husvéth, Károly Dublecz
Diets rich in various soluble nondigestible carbohydrates (sNDCs) were evaluated on different intestinal characteristics (histological, physico-chemical and microbiological) of chickens and compared with a maize-based diet as a control. A total of 160 Ross 308 male chickens were kept in deep litter pens (n = 40) and fed their appropriate diets from Day 1 to Day 35 of life. Four isocaloric and isonitrogenous diets, differing in their sNDC content, were composed; control (containing maize as the only cereal), maize-wheat-based (M + W) and maize-based supplemented with either 20 g/kg inulin (M + I) or 30 g/kg lactose (M + L)...
September 16, 2018: Journal of Animal Physiology and Animal Nutrition
Heddie Mejborn, Max Hansen, Anja Biltoft-Jensen, Tue Christensen, Karin Hess Ygil, Pelle Thonning Olesen
Carcinogenic effects in humans are ascribed to processed meat by organisations such as International Agency for Research on Cancer, World Cancer Research Fund and American Institute for Cancer Research. However, the term 'processed meat' covers a heterogenic group of products whose content of potential hazards differ considerably. To improve estimates of associations between processed meat intake and cancer risk we investigated ways to divide processed meat into subgroups that more precisely reflects its carcinogenic characteristics...
August 30, 2018: Meat Science
Steven J Micheletti, Jon E Hess, Joseph S Zendt, Shawn R Narum
BACKGROUND: Disparity in the timing of biological events occurs across a variety of systems, yet the understanding of genetic basis underlying diverse phenologies remains limited. Variation in maturation timing occurs in steelhead trout, which has been associated with greb1L, an oestrogen target gene. Previous techniques that identified this gene only accounted for about 0.5-2.0% of the genome and solely investigated coastal populations, leaving uncertainty on the genetic basis of this trait and its prevalence across a larger geographic scale...
September 15, 2018: BMC Evolutionary Biology
Dusit Adstamongkonkul, David C Hess
Hypoxic Ischemic Encephalopathy (HIE) is the result of severe anoxic brain injury during the neonatal period and causes life-long morbidity and premature mortality. Currently, therapeutic hypothermia immediately after birth is the standard of care for clinically relevant HIE. However, therapeutic hypothermia alone does not provide complete neuroprotection and there is an urgent need for adjunctive therapies. Ischemic conditioning is an adaptive process of endogenous protection in which small doses of sub-lethal ischemia can provide a protection against a lethal ischemic event...
December 2017: Conditioning medicine
Anshu Mahajan, Biplab Das, Karanjit Singh Narang, Ajaya Nand Jha, Varindera Paul Singh, Harsh Sapra, Gaurav Goel
BACKGROUND: Use of surpass FD device in the treatment of acutely ruptured aneurysm has not been well studied and reported in literature. METHODS: We retrospectively reviewed patients having SAH who were treated by surpass FD placement at our hospital between June 2016 and March 2018. Detail analysis of medical records were done to obtain patient age, gender, clinical history, Hunt-Hess grade, Fischer grade, results of radiographic and procedural details including technical success and complication, clinical outcome and follow up angiographic results...
September 10, 2018: World Neurosurgery
Elisabeth Bründl, Martin Proescholdt, Petra Schödel, Sylvia Bele, Julius Höhne, Florian Zeman, Eva-Maria Stoerr, Alexander Brawanski, Karl-Michael Schebesch
OBJECTIVES: Neuropsychological dysfunction after treatment of spontaneous subarachnoid haemorrhage (sSAH) is common but underreported. The vasoconstrictor neuropeptide Y (NPY) is excessively released after sSAH and in psychiatric disorders. We prospectively analysed the treatment-specific differences in the secretion of endogenous cerebrospinal fluid (CSF) NPY during the acute stage after sSAH and its impact on cognitive processing. METHODS: A total of 26 consecutive patients (f:m = 13:8; mean age 50...
September 14, 2018: Neurological Research
Thomas M Hess, Claire M Growney, Allura F Lothary
The impact of aging stereotypes on task engagement was examined. Older adults (N = 144, ages 65 to 85) were exposed to primes designed to activate positive or negative stereotypes about aging, with half of the individuals in each stereotype group also assigned to a high-accountability condition to enhance motivation. Participants performed a memory-scan task comprising 2 levels of demands (memory sets of 4 or 7 items), with 2 blocks (5 min each) at each level. Systolic blood pressure recorded throughout the task was used to monitor engagement levels...
September 13, 2018: Psychology and Aging
Michaela Katja Stangl, Wolfgang Böcker, Vladimir Chubanov, Uta Ferrari, Michael Fischereder, Thomas Gudermann, Eric Hesse, Peter Meinke, Martin Reincke, Nicole Reisch, Maximilian M Saller, Jochen Seissler, Ralf Schmidmaier, Benedikt Schoser, Cornelia Then, Barbara Thorand, Michael Drey
Sarcopenia in geriatric patients is often associated with or even caused by changes of the endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and additional multimorbidity in geriatric patients makes it difficult to study distinct pathogenic pathways leading to sarcopenia. Patients suffering from diabetes, Cushing's syndrome, chronic kidney disease, Klinefelter's syndrome or motor neuron diseases, such as amyotrophic lateral sclerosis for example are known to have impaired muscle property and reduced physical performance...
September 10, 2018: Experimental and Clinical Endocrinology & Diabetes
Alexandra Maas, Moritz Losacker, Cornelius Hess
Methamphetamine can be synthesized either enantiopure or in its racemic form. We separated (R)- and (S)-enantiomers of methamphetamine and amphetamine by a fast LC-MS/MS-method using a Lux® 3μm AMP 150×3.0mm analytical column after simple protein precipitation with methanol. Sufficient resolution could be achieved. Method validation for qualitative detection showed limits of quantification <5ng/mL while only little (maximum 14.5%) ion suppression could be shown. Stability in the processed sample could be achieved using isotopically labelled internal standards...
August 20, 2018: Forensic Science International
Thomas M Hess, Claire M Growney, Erica L O'Brien, Shevaun D Neupert, Andrew Sherwood
Engagement in cognitively demanding everyday activities has been shown to benefit cognitive health in later life. We investigated the factors that influence engagement, with specific interest in determining the extent to which the costs of engaging cognitive resources are associated with intrinsic motivation and, ultimately, participation in everyday activities. Older adults (N = 153) aged from 65 to 81 years completed a challenging cognitive task, with the costs of cognitive engagement-operationalized as the effort required to maintain performance-assessed using systolic blood pressure responses (SBP-R)...
September 2018: Psychology and Aging
Deike Hesse, Jan Trost, Nadine Schäfer, Kristin Schwerbel, Andreas Hoeflich, Annette Schürmann, Gudrun A Brockmann
Besides liver, IGF-I is expressed in adipose tissue. However, the effects of this local IGF-I on adipose tissue and metabolism are unclear. We generated adipocyte-specific knock-out mice on the background of the Berlin Fat Mouse Inbred (BFMI) line to evaluate the contribution of adipocyte-IGF-I on glucose metabolism and adipose tissue development. BFMI mice are obese, non-diabetic with elevated plasma insulin and IGF-I concentration. The knock-out in adipocytes led to a total white adipose tissue expression of 50-60% due to unaltered Igf-1 expression in stromavascular cells...
April 2018: Growth Factors
Julia Hesse, Carina Braun, Sidney Behringer, Uta Matysiak, Ute Spiekerkoetter, Sara Tucci
Very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is the most common defect of mitochondrial β-oxidation of long-chain fatty acids. However, the unambiguous diagnosis of true VLCADD patients may be challenging, and a high rate of false positive individuals identified by newborn screening undergo confirmation diagnostics. In this study, we show the outcome of enzyme testing in lymphocytes as a confirmatory tool in newborns identified by screening, and the correlation with molecular sequencing of the ACADVL gene...
September 7, 2018: Journal of Inherited Metabolic Disease
Eamon K Conway, Aleksandra A Kyuberis, Oleg L Polyansky, Jonathan Tennyson, Nikolai F Zobov
A new global and highly accurate ab initio dipole moment surface (DMS) for water vapour is presented. This DMS is based on a set of 17 628 multi-reference configuration interaction data points that were calculated with the aug-cc-pCV6Z basis set with the Douglas-Kroll-Hess Hamiltonian; tests are performed at several other levels of ab initio theory. This new "CKAPTEN" DMS improves agreement with recent experimental measurements compared with previous models that poorly predicted some bands in the infrared while also maintaining or improving on the agreement for all remaining strong lines...
August 28, 2018: Journal of Chemical Physics
Thorsten Stahl, Matthias Gaßmann, Sandy Falk, Hubertus Brunn
A total of 201 sewage sludge and 45 biowaste samples were examined for 14 different perfluoroal-kyl acids (PFAA). For perfluorooctanesulfonic acid, maximum concentrations of 698 µg/kg dry weight were measured in sewage sludge and for perfluorohexane sulfonic acid 29.0 µg/kg dry weight were found in biowaste. Looking at the fingerprints of both these matrices it can be see that long-chain PFAA make up 85.9% of the total concentration in sewage sludge whereas short-chain PFAA only account for 14.1%. In contrast, the trend in biowaste is just the opposite, with 53...
September 7, 2018: Journal of Agricultural and Food Chemistry
Sophie K M Heinrichs, Timo Hess, Jessica Becker, Lutz Hamann, Yogesh K Vashist, Katja Butterbach, Thomas Schmidt, Hakan Alakus, Iurii Krasniuk, Aksana Höblinger, Philipp Lingohr, Monika Ludwig, Alexander F Hagel, Claus W Schildberg, Lothar Veits, Ugne Gyvyte, Katharina Weise, Vitalia Schüller, Anne C Böhmer, Julia Schröder, Jan Gehlen, Nicole Kreuser, Sebastian Hofer, Hauke Lang, Florian Lordick, Peter Malfertheiner, Markus Moehler, Oliver Pech, Nikolaos Vassos, Ernst Rodermann, Jakob R Izbicki, Martin Kruschewski, Katja Ott, Ralf R Schumann, Michael Vieth, Elisabeth Mangold, Evita Gasenko, Limas Kupcinskas, Hermann Brenner, Peter Grimminger, Luis Bujanda, Federico Sopeña, Jesús Espinel, Concha Thomson, Ángeles Pérez-Aísa, Rafael Campo, Fernando Geijo, Daniela Collette, Christiane Bruns, Katharina Messerle, Ines Gockel, Markus M Nöthen, Hans Lippert, Karsten Ridwelski, Angel Lanas, Gisela Keller, Michael Knapp, Marcis Leja, Juozas Kupcinskas, Maria A García-González, Marino Venerito, Johannes Schumacher
Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants...
September 6, 2018: Cancer Medicine
Yi Li, Matthew J Barkovich, Celeste M Karch, Ryan M Nillo, Chun-Chieh Fan, Iris J Broce, Chin Hong Tan, Daniel Cuneo, Christopher P Hess, William P Dillon, Orit A Glenn, Christine M Glastonbury, Nicholas Olney, Jennifer S Yokoyama, Luke W Bonham, Bruce Miller, Aimee Kao, Nicholas Schmansky, Bruce Fischl, Ole A Andreassen, Terry Jernigan, Anders Dale, A James Barkovich, Rahul S Desikan, Leo P Sugrue
Tuberous sclerosis complex (TSC), a heritable neurodevelopmental disorder, is caused by mutations in the TSC1 or TSC2 genes. To date, there has been little work to elucidate regional TSC1 and TSC2 gene expression within the human brain, how it changes with age, and how it may influence disease. Using a publicly available microarray dataset, we found that TSC1 and TSC2 gene expression was highest within the adult neo-cerebellum and that this pattern of increased cerebellar expression was maintained throughout postnatal development...
September 6, 2018: Scientific Reports
Kumar Vaibhav, Molly Braun, Mohammad Badruzzaman Khan, Sumbul Fatima, Nancy Saad, Adarsh Shankar, Zenab T Khan, Ruth B S Harris, Qiuhua Yang, Yuqing Huo, Ali S Arbab, Shailendra Giri, Cargill H Alleyne, John R Vender, David C Hess, Babak Baban, Md Nasrul Hoda, Krishnan M Dhandapani
Spontaneous intracerebral hemorrhage (ICH) produces the highest acute mortality and worst outcomes of all stroke subtypes. Hematoma volume is an independent determinant of ICH patient outcomes, making clot resolution a primary goal of clinical management. Herein, remote-limb ischemic post-conditioning (RIC), the repetitive inflation-deflation of a blood pressure cuff on a limb, accelerated hematoma resolution and improved neurological outcomes after ICH in mice. Parabiosis studies revealed RIC accelerated clot resolution via a humoral-mediated mechanism...
September 6, 2018: Journal of Experimental Medicine
S Post, I H Heijink, L Hesse, H K Koo, F Shaheen, M Fouadi, V N S Kuchibhotla, B N Lambrecht, A J M Van Oosterhout, T L Hackett, M C Nawijn
The airway epithelium regulates responses to aeroallergens, acting as a physical and immunological barrier. In asthma, epithelial barrier function and the expression of adherens junction protein E-cadherin is compromised, but it is unknown whether this is cause or consequence of the disease. We hypothesized that airway epithelial loss of E-cadherin is a critical step in the development of manifestations of asthma. We generated a transgenic mouse model with conditional loss of E-cadherin in lung epithelial cells at birth and onwards...
September 5, 2018: Scientific Reports
Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser, Massimo Lopes
Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair processes at stalled or converging replication forks. Recent evidence challenged this view, proposing that single forks traverse ICLs by yet elusive mechanisms. Combining ICL immunolabeling and single-molecule approaches in human cells, we now show that ICL induction leads to global replication fork slowing, involving forks not directly challenged by ICLs...
September 4, 2018: Cell Reports
Xian Chen, Kwang Hui Low, Angela Alexander, Yufeng Jiang, Cansu Karakas, Kenneth R Hess, Jason P Carey, Tuyen Bui, Smruthi Vijayaraghavan, Kurt W Evans, Min Yi, D Christian Ellis, Kwok-Leung Cheung, Ian O Ellis, Siqing Fu, Funda Meric-Bernstam, Kelly K Hunt, Khandan Keyomarsi
PURPOSE: Poor prognosis in triple-negative breast cancer (TNBC) is due to an aggressive phenotype and lack of biomarker-driven targeted therapies. Overexpression of cyclin E and phosphorylated-CDK2 are correlated with poor survival in TNBC patients, and the absence of CDK2 desensitizes cells to inhibition of Wee1 kinase, a key cell cycle regulator. We hypothesize that cyclin E expression can predict response to therapies, which include the Wee1 kinase inhibitor, AZD1775. EXPERIMENTAL DESIGN: Mono and combination therapies with AZD1775 were evaluated in TNBC cell lines and multiple patient derived xenograft (PDX) models with different cyclin E expression profiles...
September 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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