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https://www.readbyqxmd.com/read/29454525/radial-umbilical-dermatofasciolysis-to-invert-the-skin-following-umbilical-herniorrhaphy
#1
Emma J Cordes, Melanie LaPlant, Daniel A Saltzman, Robert D Acton, Bradley J Segura, Donavon J Hess
BACKGROUND: Umbilical hernia is a common congenital anomaly, and can result in the appearance of a protuberant umbilicus. In select cases, inversion of the umbilical skin can be impaired by the presence of thickened dermis or fascial remnants of the umbilical stalk. DESCRIPTION OF OPERATIVE TECHNIQUE: After umbilical herniorrhaphy, the skin is everted over the left index finger and radial partial thickness incisions in the fascia and dermis of the undersurface of the umbilicus...
February 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29454461/fluoridation-advocacy-in-referenda-where-media-coverage-is-balanced-yet-biased
#2
John A Curiel, Anne E Sanders, Thu-Mai L Christian, Sophia Lafferty-Hess, Thomas M Carsey, Lewis N Lampiris, Gary D Slade
BACKGROUND: Despite supporting scientific evidence, community water fluoridation (CWF) often fails in public referenda. To understand why, the authors quantitatively analyzed text from news media coverage of CWF referenda. METHODS: The authors analyzed text from 234 articles covering 11 CWF referenda conducted in 3 US cities from 1956 through 2013. The authors used cluster analysis to identify each article's core rhetoric and classified it according to sentiment and tone...
February 14, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29452664/the-role-of-stem-cell-transplantation-in-follicular-lymphoma
#3
REVIEW
Georg Hess
With the introduction of novel treatments paradigms to if or when to use transplantation strategies for patients with follicular lymphoma have changed substantially. Autologous transplantation has been intensively evaluated as consolidation after first induction treatment with positive effects, however the introduction of Rituximab led to comparable improvements and HDT has been moved to relapse treatment. In this indication HDT was frequently use already at first relapse, but now is dominantly used in patients with a highrisk profile, e...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29451855/in-vivo-labeling-by-cd73-marks-multipotent-stromal-cells-and-highlights-endothelial-heterogeneity-in-the-bone-marrow-niche
#4
Martin Breitbach, Kenichi Kimura, Tiago C Luis, Christopher J Fuegemann, Petter S Woll, Michael Hesse, Raffaella Facchini, Sarah Rieck, Katarzyna Jobin, Julia Reinhardt, Osamu Ohneda, Daniela Wenzel, Caroline Geisen, Christian Kurts, Wolfgang Kastenmüller, Michael Hölzel, Sten E W Jacobsen, Bernd K Fleischmann
Despite much work studying ex vivo multipotent stromal cells (MSCs), the identity and characteristics of MSCs in vivo are not well defined. Here, we generated a CD73-EGFP reporter mouse to address these questions and found EGFP + MSCs in various organs. In vivo, EGFP + mesenchymal cells were observed in fetal and adult bones at proliferative ossification sites, while in solid organs EGFP + cells exhibited a perivascular distribution pattern. EGFP + cells from the bone compartment could be clonally expanded ex vivo from single cells and displayed trilineage differentiation potential...
February 1, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29451404/optimizing-nbe-pk-pd-assays-using-the-gyrolab-affinity-software-conveniently-within-the-bioanalyst-s-existing-workflow
#5
Maria Myzithras, Tammy Bigwarfe, Erica Waltz, Hua Li, Jennifer Ahlberg, Irina Rybina, Sarah Low, Cynthia Hess Kenny, John Miglietta, Rachel Kroe-Barrett
AIM: The fully automated microfluidics-based Gyrolab is a popular instrument for the bioanalysis of protein therapeutics; requiring minimal sample and reagent volumes. Gyros offers affinity software for determining binding affinity in solution using a high-throughput method and miniaturized reactions. RESULTS: Using this affinity software, multiple CTGF-targeting reagents were characterized on the Gyrolab after <100% target coverage was seen in a cynomolgus pharmacokinetic/PD study dosed with anti-CTGF antibodies...
February 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29451369/discovery-of-rogaratinib-bay-1163877-a-pan-fgfr-inhibitor
#6
Marie-Pierre Collin, Mario Lobell, Walter Hübsch, Dirk Brohm, Hartmut Schirok, Rolf Jautelat, Klemens Lustig, Ulf Bömer, Verena Vöhringer, Mélanie Héroult, Sylvia Grünewald, Holger Hess-Stumpp
Rogaratinib (BAY 1163877) is a highly potent and selective small-molecule pan-fibroblast growth factor receptor (FGFR) inhibitor (FGFR1-4) for oral application currently being investigated in phase 1 clinical trials for the treatment of cancer. In this publication, we report its discovery by de novo structure-based design and medicinal chemistry optimization together with its pharmacokinetic profile.
February 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29451003/escherichia-coli-isolates-from-femoral-bone-marrow-of-broilers-exhibit-diverse-pheno-and-genotypic-characteristics-that-do-not-correlate-with-macroscopic-lesions-of-bacterial-chondronecrosis-with-osteomyelitis-bco
#7
Barbara Gaußmann, Claudia Hess, Beatrice Grafl, Mercedes Kovacs, Salome Troxler, Beatrix Stessl, Michael Hess, Surya Paudel
The pheno- and genotypic relatedness among Escherichia coli isolates from broilers with and without macroscopic lesions on the femoral head were investigated. In total, 219 isolates obtained from the bone marrow were characterized by serotyping, antimicrobial resistance profiles (AMR), phylogenetic grouping, detection of virulence-associated genes (VAG) and pulsed-field gel electrophoresis (PFGE). Serotyping revealed that 48.4% of the isolates were assigned to one of the three serotypes (O78:K80: 21.0%, O2:K1: 18...
February 16, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29449192/association-of-body-mass-index-and-outcomes-in-patients-with-metastatic-melanoma-treated-with-targeted-therapy-immunotherapy-or-chemotherapy-a-retrospective-multicohort-analysis
#8
Jennifer L McQuade, Carrie R Daniel, Kenneth R Hess, Carmen Mak, Daniel Y Wang, Rajat R Rai, John J Park, Lauren E Haydu, Christine Spencer, Matthew Wongchenko, Stephen Lane, Dung-Yang Lee, Mathilde Kaper, Meredith McKean, Kathryn E Beckermann, Samuel M Rubinstein, Isabelle Rooney, Luna Musib, Nageshwar Budha, Jessie Hsu, Theodore S Nowicki, Alexandre Avila, Tomas Haas, Maneka Puligandla, Sandra Lee, Shenying Fang, Jennifer A Wargo, Jeffrey E Gershenwald, Jeffrey E Lee, Patrick Hwu, Paul B Chapman, Jeffrey A Sosman, Dirk Schadendorf, Jean-Jacques Grob, Keith T Flaherty, Dana Walker, Yibing Yan, Edward McKenna, Jeffrey J Legos, Matteo S Carlino, Antoni Ribas, John M Kirkwood, Georgina V Long, Douglas B Johnson, Alexander M Menzies, Michael A Davies
BACKGROUND: Obesity has been linked to increased mortality in several cancer types; however, the relation between obesity and survival outcomes in metastatic melanoma is unknown. The aim of this study was to examine the association between body-mass index (BMI) and progression-free survival or overall survival in patients with metastatic melanoma who received targeted therapy, immunotherapy, or chemotherapy. METHODS: This retrospective study analysed independent cohorts of patients with metastatic melanoma assigned to treatment with targeted therapy, immunotherapy, or chemotherapy in randomised clinical trials and one retrospective study of patients treated with immunotherapy...
February 12, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29446874/transplant-recipients-are-vulnerable-under-the-medicare-part-d-benefit
#9
Lisa M Potter, Angela Q Maldonado, Krista L Lentine, Mark A Schnitzler, Zidong Zhang, Gregory P Hess, Edward Garrity, Bertram L Kasiske, David A Axelrod
Transplant immunosuppressants are often used off-label due to insufficient randomized prospective trial data to achieve organ-specific US Food and Drug Administration (FDA) approval. Transplant recipients who rely on Medicare Part D for immunosuppressant drug coverage are vulnerable to coverage denial for off-label prescriptions, unless use is supported by Centers for Medicare & Medicaid Services (CMS)-approved compendia. An integrated data set including national transplant registry data and 3 years of dispensed pharmacy records was used to identify the prevalence of immunosuppression use that is both off-label and not supported by CMS-approved compendia...
February 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29445244/permeability-and-ammonia-selectivity-in-aquaporin-tip2-1-linking-structure-to-function
#10
Viveca Lindahl, Pontus Gourdon, Magnus Andersson, Berk Hess
Aquaporin TIP2;1 is a protein channel permeable to both water and ammonia. The structural origin of ammonia selectivity remains obscure, but experiments have revealed that a double mutation renders it impermeable to ammonia without affecting water permeability. Here, we aim to reproduce and explain these observations by performing an extensive mutational study using microsecond long molecular dynamics simulations, applying the two popular force fields CHARMM36 and Amber ff99SB-ILDN. We calculate permeabilities and free energies along the channel axis for ammonia and water...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445131/strains-of-the-toxic-and-bloom-forming-nodularia-spumigena-cyanobacteria-can-degrade-methylphosphonate-and-release-methane
#11
Jonna E Teikari, David P Fewer, Rashmi Shrestha, Shengwei Hou, Niina Leikoski, Minna Mäkelä, Asko Simojoki, Wolfgang R Hess, Kaarina Sivonen
Nodularia spumigena is a nitrogen-fixing cyanobacterium that forms toxic blooms in the Baltic Sea each summer and the availability of phosphorous is an important factor limiting the formation of these blooms. Bioinformatic analysis identified a phosphonate degrading (phn) gene cluster in the genome of N. spumigena suggesting that this bacterium may use phosphonates as a phosphorus source. Our results show that strains of N. spumigena could grow in medium containing methylphosphonic acid (MPn) as the sole source of phosphorous and released methane when growing in medium containing MPn...
February 14, 2018: ISME Journal
https://www.readbyqxmd.com/read/29444697/modulation-of-pro-apoptotic-effects-and-mitochondrial-potential-on-b16f10-cells-by-dodac-pho-s-liposomes
#12
Arthur Cássio de Lima Luna, José Roberto de Assis Santos Filho, Henrique Hesse, Salvador Claro Neto, Gilberto Orivaldo Chierice, Durvanei Augusto Maria
OBJECTIVE: We aimed to evaluate the potential of DODAC/PHO-S liposomes on the modulation of the expression of pro-apoptotic proteins, loss of lysosomal integrity and the mitochondrial electrical potential, compared with phosphoethanolamine. RESULTS: The results of this study demonstrate that DODAC/PHO-S liposomes have exhibited broad cytotoxic potential in B16F10 murine melanoma cells, with significantly greater proportions than treatment with PHO-S. The treatment with the DODAC/PHO-S 2...
February 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29444255/identification-of-the-dna-methyltransferases-establishing-the-methylome-of-the-cyanobacterium-synechocystis-sp-pcc-6803
#13
Martin Hagemann, Katrin Gärtner, Matthias Scharnagl, Paul Bolay, Steffen C Lott, Janina Fuss, Bruno Huettel, Richard Reinhardt, Stephan Klähn, Wolfgang R Hess
DNA methylation in bacteria is important for defense against foreign DNA, but is also involved in DNA repair, replication, chromosome partitioning, and regulatory processes. Thus, characterization of the underlying DNA methyltransferases in genetically tractable bacteria is of paramount importance. Here, we characterized the methylome and orphan methyltransferases in the model cyanobacterium Synechocystis sp. PCC 6803. Single molecule real-time (SMRT) sequencing revealed four DNA methylation recognition sequences in addition to the previously known motif m5CGATCG, which is recognized by M...
February 12, 2018: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29442342/a-ten-year-follow-up-study-of-treatment-outcome-of-craniopharyngiomas
#14
Lukas Andereggen, Benjamin Hess, Robert Andres, Marwan El-Koussy, Luigi Mariani, Andreas Raabe, Rolf W Seiler, Emanuel Christ
PURPOSE: Craniopharyngioma-related hypothalamic obesity is a devastating complication with limited data on whether long-term follow-up should focus on problems other than endocrine deficiencies and weight gain. The primary endpoint was the assessment of predictors of hypothalamic obesity development; the secondary endpoint was the assessment of functional outcome (endocrine deficiencies, visual acuity) at long-term follow-up. METHODS: This retrospective case-note study examined craniopharyngioma patients with at least 2 years of follow-up...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442128/semantic-imaging-features-predict-disease-progression-and-survival-in-glioblastoma-multiforme-patients
#15
Jan C Peeken, Josefine Hesse, Bernhard Haller, Kerstin A Kessel, Fridtjof Nüsslin, Stephanie E Combs
BACKGROUND: For glioblastoma (GBM), multiple prognostic factors have been identified. Semantic imaging features were shown to be predictive for survival prediction. No similar data have been generated for the prediction of progression. The aim of this study was to assess the predictive value of the semantic visually accessable REMBRANDT [repository for molecular brain neoplasia data] images (VASARI) imaging feature set for progression and survival, and the creation of joint prognostic models in combination with clinical and pathological information...
February 13, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29438493/history-of-estrogen-in-the-male-an-historical-perspective
#16
Rex A Hess, Paul S Cooke
Estrogens have traditionally been considered female hormones. Nevertheless, the presence of estrogenic substances in males has been known for over 90 years. Initial work with estrogen suggested that it was deleterious to male reproduction because exogenous estrogen treatments induced developmental abnormalities. However, demonstrations of estrogen synthesis in the testis and high concentrations of 17β-estradiol (E2) in rete testis fluid suggested that the female hormone might have a function in normal male reproduction...
February 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29438150/understanding-your-documentation-requirements
#17
Cathy Thomas Hess
No abstract text is available yet for this article.
March 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29437522/inhibition-of-human-papillomavirus-type-16-infection-using-an-rna-aptamer
#18
Diana Gabriela Valencia-Reséndiz, Giovanni Palomino-Vizcaino, Juana Virginia Tapia-Vieyra, María Luisa Benítez-Hess, Ana Gabriela Leija-Montoya, Luis Marat Alvarez-Salas
Human papillomavirus type 16 (HPV16) DNA has been found in ∼50% of cervical tumors worldwide. HPV infection starts with the binding of the virus capsid to heparan sulfate (HS) receptors exposed on the surface of epithelial basal layer keratinocytes. Previously, our group isolated a high-affinity RNA aptamer (Sc5c3) specific for HPV16 L1 virus-like particles (VLPs). In this study, we report the inhibition of HPV16 infection by Sc5c3 in a pseudovirus (PsVs) model. 293TT cells were infected by HPV16 PsVs containing the yellow fluorescent protein (YFP) as reporter gene...
February 13, 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29437490/h2-receptor-antagonist-use-and-mortality-in-pulmonary-hypertension-insight-from-the-va-cart-program
#19
Peter J Leary, Edward Hess, Anna E Barón, Kelley R Branch, Gaurav Choudhary, Catherine L Hough, Bradley A Maron, David D Ralph, John J Ryan, Ryan J Tedford, Noel S Weiss, Roham T Zamanian, Tim Lahm
No abstract text is available yet for this article.
February 13, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29435401/rapid-synthesis-of-sub-10%C3%A2-nm-hexagonal-nayf4-based-upconverting-nanoparticles-using-therminol%C3%A2-%C3%A2-66
#20
Julia Hesse, Dennis T Klier, Massimo Sgarzi, Anne Nsubuga, Christoph Bauer, Jörg Grenzer, René Hübner, Marcus Wislicenus, Tanmaya Joshi, Michael U Kumke, Holger Stephan
We report a simple one-pot method for the rapid preparation of sub-10 nm pure hexagonal (β-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol® 66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions)...
February 2018: ChemistryOpen
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