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https://www.readbyqxmd.com/read/28718765/a-connectome-of-a-learning-and-memory-center-in-the-adult-drosophila-brain
#1
Shin-Ya Takemura, Yoshinori Aso, Toshihide Hige, Allan Wong, Zhiyuan Lu, C Shan Xu, Patricia K Rivlin, Harald F Hess, Ting Zhao, Toufiq Parag, Stuart Berg, Gary Huang, William Katz, Donald J Olbris, Stephen Plaza, Lowell Umayam, Roxanne Aniceto, Lei-Ann Chang, Shirley Lauchie, Omotara Ogundeyi, Christopher Ordish, Aya Shinomiya, Christopher Sigmund, Satoko Takemura, Julie Tran, Glenn C Turner, Gerald M Rubin, Louis K Scheffer
Understanding memory formation, storage and retrieval requires knowledge of the underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of associative learning. We reconstructed the morphologies and synaptic connections of all 983 neurons within the three functional units, or compartments, that compose the adult MB's α lobe, using a dataset of isotropic 8-nm voxels collected by focused ion-beam milling scanning electron microscopy. We found that Kenyon cells (KCs), whose sparse activity encodes sensory information, each make multiple en passant synapses to MB output neurons (MBONs) in each compartment...
July 18, 2017: ELife
https://www.readbyqxmd.com/read/28718134/der-fluch-der-italienischen-vornamen
#2
Luise Hess
No abstract text is available yet for this article.
July 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28717653/individual-social-and-environmental-correlates-of-active-transportation-patterns-in-french-women
#3
Camille Perchoux, Christophe Enaux, Jean-Michel Oppert, Mehdi Menai, Hélène Charreire, Paul Salze, Christiane Weber, Serge Hercberg, Thierry Feuillet, Franck Hess, Célina Roda, Chantal Simon, Julie-Anne Nazare
The objectives were (1) to define physical activity (PA) and sedentary behaviors (SB) patterns in daily life contexts (work, leisure, and transportation) in French working women from NutriNet-Santé web-cohort and (2) to identify pattern(s) of active transportation and their individual, social, and environmental correlates. 23,432 participants completed two questionnaires to evaluate PA and SB in daily life contexts and individual representations of residential neighborhood and transportation modes. Hierarchical cluster analysis was performed which identified 6 distinct movement behavior patterns: (i) active occupation, high sedentary leisure, (ii) sedentary occupation, low leisure, (iii) sedentary transportation, (iv) sedentary occupation and leisure, (v) active transportation, and (vi) active leisure...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28717190/interocular-contrast-difference-drives-illusory-3d-percept
#4
Alexandre Reynaud, Robert F Hess
Any processing delay between the two eyes can result in illusory 3D percepts for moving objects because of either changes in the pure disparities over time for disparity sensors or by changes to sensors that encode motion/disparity conjointly. This is demonstrated by viewing a fronto-parallel pendulum through a neutral density (ND) filter placed over one eye, resulting in the illusory 3D percept of the pendulum following an elliptical orbit in depth, the so-called Pulfrich phenomenon. Here we use a paradigm where a cylinder rotating in depth, defined by moving Gabor patches is presented at different interocular phases, generating strong to ambiguous depth percepts...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716645/update-in-management-of-severe-hypoxemic-respiratory-failure
#5
REVIEW
Dharani Kumari Narendra, Dean R Hess, Curtis N Sessler, Habtamu M Belete, Kalpalatha K Guntupalli, Felix Khusid, Charles Mark Carpati, Mark Elton Astiz, Suhail Raoof
Mortality related to severe-moderate and severe ARDS remains high. We searched the literature to update this topic. We defined severe hypoxemic respiratory failure as PaO2/FIO2 < 150 mm Hg (i.e., severe-moderate and severe ARDS). For these patients, we support setting the ventilator to a tidal volume of 4-8 mL/kg predicted body weight (PBW) with plateau pressure ≤30 cm H2O, and initial PEEP of 10 - 12 cm H2O. To promote alveolar recruitment, we propose increasing PEEP in increments of 2 - 3 cm, provided plateau pressure remains ≤30 cm H2O and driving pressure does not increase...
July 14, 2017: Chest
https://www.readbyqxmd.com/read/28715309/rise-of-the-nanorobots-advances-in-control-molecular-detection-and-nanoscale-actuation-are-bringing-us-closer-to-a-new-era-of-technology-enhanced-by-nanorobots
#6
Stanislav Tsitkov, Henry Hess
In 1988, a Scientific American article by A.K. Dewdney [1] on the work of nanotechnologist K. Eric Drexler spurred public interest in the nascent field of nanotechnology and its potential for advancing humanity into a new technological age. The article portrayed a world run by nanoscale machines that could operate in any environment (Figure 1), with uses ranging from fighting infections in the human body to building tomorrow's skyscrapers. Nearly 30 years later, these visions of the future are closer than ever...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28712527/clinical-presentation-to-the-emergency-department-predicts-subarachnoid-hemorrhage-associated-myocardial-injury
#7
Khalil M Yousef, Elizabeth Crago, Theodore F Lagattuta, Marilyn Hravnak
INTRODUCTION: Aneurysmal subarachnoid hemorrhage (aSAH) is frequently seen in emergency departments. Secondary injury, such as subarachnoid hemorrhage-associated myocardial injury (SAHMI), affects one third of survivors and contributes to poor outcomes. SAHMI is not attributed to ischemia from myocardial disease but can result in hypotension and arrhythmias. It is important that emergency nurses recognize which clinical presentation characteristics are predictive of SAHMI to initiate proper interventions...
July 13, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28711292/perioperative-stroke-after-cerebral-aneurysm-clipping-risk-factors-and-postoperative-impact
#8
Ahmed I Kashkoush, Brian T Jankowitz, Chris Nguyen, Paul A Gardner, Daniel A Wecht, Robert M Friedlander, Yue-Fang Chang, Miguel Habeych, Donald Crammond, Jeffrey Balzer, Parthasarathy D Thirumala
Stroke is a devastating complication after intracranial aneurysm clipping. Understanding the risk factors that prognosticate perioperative stroke may help to identify patients that would benefit from neuroprotective therapy. This study assesses patient-specific independent predictors of perioperative stroke in relation to surgical aneurysm clipping. Additionally, this study evaluates the postoperative complications of stroke. We performed a retrospective chart review of 437 patients with ruptured and unruptured intracranial aneurysms, which underwent surgical clipping from 2006 to 2013...
July 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28710530/proteomic-characterisation-reveals-active-wnt-signalling-by-human-multipotent-stromal-cells-as-a-key-regulator-of-beta-cell-survival-and-proliferation
#9
Miljan Kuljanin, Gillian I Bell, Stephen E Sherman, Gilles A Lajoie, David A Hess
AIMS/HYPOTHESIS: Novel strategies to stimulate the expansion of beta cell mass in situ are warranted for diabetes therapy. The aim of this study was to elucidate the secretome of human bone marrow (BM)-derived multipotent stromal cells (MSCs) with documented islet regenerative paracrine function. We hypothesised that regenerative MSCs will secrete a unique combination of protein factors that augment islet regeneration. METHODS: Human BM-derived MSCs were examined for glucose-lowering capacity after transplantation into streptozotocin-treated NOD/severe combined immunodeficiency (SCID) mice and segregated into samples with regenerative (MSC(R)) vs nonregenerative (MSC(NR)) capacity...
July 14, 2017: Diabetologia
https://www.readbyqxmd.com/read/28706090/improving-site-selection-in-clinical-studies-a-standardised-objective-multistep-method-and-first-experience-results
#10
Anahí Hurtado-Chong, Alexander Joeris, Denise Hess, Michael Blauth
INTRODUCTION: A considerable number of clinical studies experience delays, which result in increased duration and costs. In multicentre studies, patient recruitment is among the leading causes of delays. Poor site selection can result in low recruitment and bad data quality. Site selection is therefore crucial for study quality and completion, but currently no specific guidelines are available. MATERIAL AND METHODS: Selection of sites adequate to participate in a prospective multicentre cohort study was performed through an open call using a newly developed objective multistep approach...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28706089/evaluation-of-the-geriatric-co-management-for-patients-with-fragility-fractures-of-the-proximal-femur-geriatric-fracture-centre-gfc-concept-protocol-for-a-prospective-multicentre-cohort-study
#11
Alexander Joeris, Anahí Hurtado-Chong, Denise Hess, Vasiliki Kalampoki, Michael Blauth
INTRODUCTION: Treatment of fractures in the elderly population is a clinical challenge due partly to the presence of comorbidities. In a Geriatric Fracture Centre (GFC), patients are co-managed by a geriatrician in an attempt to improve clinical outcomes and reduce morbidity and mortality. Until now the beneficial effect of orthogeriatric co-management has not been definitively proven. The primary objective of this study is to determine the effect of GFC on predefined major adverse events related to a hip fracture compared to usual care centres (UCC)...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28697187/can-semiquantitative-measurements-of-suvmax-and-cut-off-values-differentiate-malignant-from-benign-colorectal-cancer
#12
Tram Nguyen, Søren Hess, Henrik Petersen, Abass Alavi, Poul Flemming Høilund-Carlsen
OBJECTIVE: We investigated maximum standardized uptake value (SUVmax) and cut-off values for differentiation of malignant and benign lesions in colorectal cancer (CC) as multiple studies have questioned their validity. We also investigated more extended indices using common semi-quantification analysis in incidental colorectal findings (ICF). SUBJECTS AND METHODS: Fluorine-18-fluoro deoxy glucose positron emission tomography/computed tomography in 25 patients with a total of 30 focal ICF was retrospectively analysed using dedicated software...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28696398/maitotoxin-4-a-novel-mtx-analog-produced-by-gambierdiscus-excentricus
#13
Francesco Pisapia, Manoëlla Sibat, Christine Herrenknecht, Korian Lhaute, Greta Gaiani, Pierre-Jean Ferron, Valérie Fessard, Santiago Fraga, Silvia M Nascimento, R Wayne Litaker, William C Holland, Catherine Roullier, Philipp Hess
Maitotoxins (MTXs) are among the most potent toxins known. These toxins are produced by epi-benthic dinoflagellates of the genera Gambierdiscus and Fukuyoa and may play a role in causing the symptoms associated with Ciguatera Fish Poisoning. A recent survey revealed that, of the species tested, the newly described species from the Canary Islands, G. excentricus, is one of the most maitotoxic. The goal of the present study was to characterize MTX-related compounds produced by this species. Initially, lysates of cells from two Canary Island G...
July 11, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28693519/tracing-the-natural-course-of-visual-acuity-and-quality-of-life-in-neovascular-age-related-macular-degeneration-a-systematic-review-and-quality-of-life-study
#14
Mari Elshout, Carroll A Webers, Margriet I van der Reis, Yvonne de Jong-Hesse, Jan S Schouten
BACKGROUND: Describing the natural course of neovascular age-related macular degeneration (nAMD) is essential in discussing prognosis and treatment options with patients and to support cost-effectiveness studies. METHODS: First, we performed a literature search in PubMed, Embase, and Cochrane. We included randomized clinical trials and prospective observational studies reporting visual acuity (VA) in non-treated patients, 24 studies in total. We integrated VA data using best fit on Lineweaver-Burke plots and modelled with non-linear regression using reciprocal terms...
July 11, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28692523/the-prognosis-factors-for-endovascular-coiling-of-aneurysm-in-patients-with-ruptured-intracranial-aneurysm
#15
Feng Zhang, Peng Li, Chao Zhang, Li Wang, Shan-Quan Jing
BACKGROUND: The spontaneous subarachnoid hemorrhage caused by aneurysm rupture often leads to a variety of complications. Endovascular coiling is effective in the treatment of ruptured intracranial aneurysm. AIM: The authors aim to evaluate the risk factors affecting the prognosis of ruptured intracranial aneurysm in patients who received endovascular coiling treatment successfully. METHODS: The demographic and clinical data including age, gender, blood pressure, blood glucose, Hunt-Hess grade, and Fisher grade at admission, Glasgow outcome scale 3 months after coiling, and the location, size of the aneurysms, coiling methods, and time of intervention were retrospectively reviewed and analyzed...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28691981/use-of-23-4-saline-in-symptomatic-vasospasm-and-cushing-s-triad-to-prevent-herniation-and-death-a-case-report
#16
Lauren M Poe, Allison M Janda, Christina F Burger, Joseph J Schlesinger
A 53-year-old woman with migraines presented with Hunt-Hess grade 5 and Fisher grade 4 subarachnoid hemorrhage with intraventricular hemorrhage. She experienced severe vasospasm requiring intra-arterial medications. Continued vasospasm and edema resulted in Cushing's triad with profound tachypnea. Three percentage saline was administered twice without improvement. Despite the general practice to wait until complete neurologic deterioration before administering 23.4% saline, it was administered on 2 separate occasions, once after the failure of the 2 boluses of 3% saline and once on the reappearance of Cushing's triad 24 hours later, and on each occasion produced overall clinical improvement...
July 6, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28687375/post-operative-stereotactic-radiosurgery-versus-observation-for-completely-resected-brain-metastases-a-single-centre-randomised-controlled-phase-3-trial
#17
Anita Mahajan, Salmaan Ahmed, Mary Frances McAleer, Jeffrey S Weinberg, Jing Li, Paul Brown, Stephen Settle, Sujit S Prabhu, Frederick F Lang, Nicholas Levine, Susan McGovern, Erik Sulman, Ian E McCutcheon, Syed Azeem, Daniel Cahill, Claudio Tatsui, Amy B Heimberger, Sherise Ferguson, Amol Ghia, Franco Demonte, Shaan Raza, Nandita Guha-Thakurta, James Yang, Raymond Sawaya, Kenneth R Hess, Ganesh Rao
BACKGROUND: After brain metastasis resection, whole brain radiotherapy decreases local recurrence, but might cause cognitive decline. We did this study to determine if stereotactic radiosurgery (SRS) to the surgical cavity improved time to local recurrence compared with that for surgical resection alone. METHODS: In this randomised, controlled, phase 3 trial, we recruited patients at a single tertiary cancer centre in the USA. Eligible patients were older than 3 years, had a Karnofsky Performance Score of 70 or higher, were able to have an MRI scan, and had a complete resection of one to three brain metastases (with a maximum diameter of the resection cavity ≤4 cm)...
July 4, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28686436/on-the-effects-of-all-electron-basis-sets-and-the-scalar-relativistic-corrections-in-the-structure-and-electronic-properties-of-niobium-clusters
#18
Fernando Néspoli Nassar Pansini, António C Neto, Miguel Gustavo de Campos Batista, Rafaela Moraes de Aquino
In this paper, an augmented all-electron double zeta basis set is used in calculations of the structure and electronic properties of small niobium clusters. The B3PW91 and M06 DFT functionals with and without second order Douglas-Kroll-Hess (DKH) scalar relativistic corrections are also utilized. Furthermore, an additional d Gaussian type function is introduced in the standard basis sets in order to improve the description of the clusters orbitals in the valence band. Our findings show that the extra d function is mportant to yield accurate results of electronic properties and, in addition, the DKH corrections can be relevant when the all-electron basis sets are used in the calculations...
July 7, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28686009/ferrocenyl-ruthenocenyl-and-benzyl-oxamniquine-derivatives-with-cross-species-activity-against-schistosoma-mansoni-and-schistosoma-haematobium
#19
Jeannine Hess, Gordana Panic, Malay Patra, Luciano Mastrobuoni, Bernhard Spingler, Saonli Roy, Jennifer Keiser, Gilles Gasser
Schistosomiasis is a parasitic disease that affects more than 250 million people annually, mostly children in poor, tropical, rural areas. Only one treatment (praziquantel) is available, putting control efforts at risk should resistance occur. In pursuit of treatment alternatives, we derivatized an old antischistosomal agent, oxamniquine (OXA). Four organometallic derivatives of OXA were synthesized and tested against Schistosoma mansoni in vitro and in vivo. Of these, a ferrocenyl derivative, 1, killed larval and adult worms 24 h postexposure in vitro, in contrast to OXA, which lacks in vitro activity against adult worms...
July 18, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28685113/adsorption-characteristics-of-er3n-c80on-w-110-and-au-111-studied-via-scanning-tunneling-microscopy-and-spectroscopy
#20
Sebastian Schimmel, Zhixiang Sun, Danny Baumann, Denis Krylov, Nataliya Samoylova, Alexey Popov, Bernd Büchner, Christian Hess
We performed a study on the fundamental adsorption characteristics of Er3N@C80 deposited on W(110) and Au(111) via room temperature scanning tunneling microscopy and spectroscopy. Adsorbed on W(110), a comparatively strong bond to the endohedral fullerenes inhibited the formation of ordered monolayer islands. In contrast, the Au(111)-surface provides a sufficiently high mobility for the molecules to arrange in monolayer islands after annealing. Interestingly, the fullerenes modify the herringbone reconstruction indicating that the molecule-substrate interaction is of considerable extent...
2017: Beilstein Journal of Nanotechnology
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