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https://www.readbyqxmd.com/read/28346962/response-to-comment-on-state-of-the-art-imaging-in-pulmonary-embolism-ventilation-perfusion-single-photon-emission-computed-tomography-versus-computed-tomography-angiography-controversies-results-and-recommendations-from-a-systematic-review
#1
https://www.readbyqxmd.com/read/28346407/insights-into-activity-and-inhibition-from-the-crystal-structure-of-human-o-glcnacase
#2
Nathaniel L Elsen, Sangita B Patel, Rachael E Ford, Dawn L Hall, Fred Hess, Hari Kandula, Maria Kornienko, John Reid, Harold Selnick, Jennifer M Shipman, Sujata Sharma, Kevin J Lumb, Stephen M Soisson, Daniel J Klein
O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a flexible dimer that displays three unique conformations and is characterized by subdomain α-helix swapping. These results identify new structural features of the substrate-binding groove adjacent to the catalytic site and open new opportunities for structural, mechanistic and drug discovery activities...
March 27, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28344146/arterial-thromboses-heralding-cholangiocarcinoma
#3
Timothy Dunn, Vivek A Rudrapatna, Shayla Hesse, Zaven Sargsyan
No abstract text is available yet for this article.
March 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28342923/giant-intracranial-aneurysms-surgical-treatment-and-risk-factors-analysis
#4
Long Xu, Xiaofeng Deng, Shuo Wang, Yong Cao, Yuanli Zhao, Dong Zhang, Yan Zhang, Rong Wang, Wei Qi, Jizong Zhao
OBJECTIVE: The surgical treatment of giant intracranial aneurysms (GIAs; diameter≥25mm) is challenging. The objective of this paper is to study the clinical outcome of GIAs treated with different surgical modalities and to analyze the factors affecting prognosis. METHODS: A consecutive series of 204 patients with GIAs who received surgical treatment in our department from 1995 to 2008 were analyzed retrospectively. The clinical outcome was evaluated with the Glasgow Outcome Scale (GOS)...
March 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28342453/ionizing-radiation-biomarkers-in-epidemiological-studies-an-update
#5
REVIEW
Janet Hall, Penny A Jeggo, Catharine West, Maria Gomolka, Roel Quintens, Christophe Badie, Olivier Laurent, An Aerts, Nataša Anastasov, Omid Azimzadeh, Tamara Azizova, Sarah Baatout, Bjorn Baselet, Mohammed A Benotmane, Eric Blanchardon, Yann Guéguen, Siamak Haghdoost, Mats Harms-Ringhdahl, Julia Hess, Michaela Kreuzer, Dominique Laurier, Ellina Macaeva, Grainne Manning, Eileen Pernot, Jean-Luc Ravanat, Laure Sabatier, Karine Tack, Soile Tapio, Horst Zitzelsberger, Elisabeth Cardis
Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30-60mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk...
January 2017: Mutation Research
https://www.readbyqxmd.com/read/28341777/respiratory-compromise-as-a-new-paradigm-for-the-care-of-vulnerable-hospitalized-patients
#6
Timothy A Morris, Peter C Gay, Neil R MacIntyre, Dean R Hess, Sandra K Hanneman, James P Lamberti, Dennis E Doherty, Lydia Chang, Maureen A Seckel
Acute respiratory compromise describes a deterioration in respiratory function with a high likelihood of rapid progression to respiratory failure and death. Identifying patients at risk for respiratory compromise coupled with monitoring of patients who have developed respiratory compromise might allow earlier interventions to prevent or mitigate further decompensation. The National Association for the Medical Direction of Respiratory Care (NAMDRC) organized a workshop meeting with representation from many national societies to address the unmet needs of respiratory compromise from a clinical practice perspective...
April 2017: Respiratory Care
https://www.readbyqxmd.com/read/28340142/multigene-signature-for-predicting-prognosis-of-patients-with-1p19q-co-deletion-diffuse-glioma
#7
Xin Hu, Emmanuel Martinez-Ledesma, Siyuan Zheng, Hoon Kim, Floris Barthel, Tao Jiang, Kenneth R Hess, Roel G W Verhaak
Background.: Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with relatively favorable overall survival; however, heterogeneous clinical outcomes are observed within this category. Methods.: We assembled gene expression profiles and sample annotation of 374 glioma patients carrying the 1p/19q co-deletion. We predicted 1p/19q status using gene expression when annotation was missing. A first cohort was randomly split into training (n = 170) and a validation dataset (n = 163)...
March 8, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28338434/coexistence-of-obstructive-sleep-apnea-worsens-the-overall-outcome-of-intracranial-aneurysm-a-pioneer-study
#8
Shyamal C Bir, Anil Nanda, Hugo Cuellar, Hai Sun, Bharat Guthikonda, Cesar Liendo, Alireza Minagar, Oleg Y Chernyshev
OBJECTIVE Obstructive sleep apnea (OSA) is associated with the progression of abdominal and thoracic aortic aneurysms. However, the role of OSA in the overall outcome of intracranial aneurysms (IAs) has not yet been established. Authors of this report investigated the role of OSA in the overall outcome of IAs. METHODS Radiological and clinical data on patients (from 2010 through 2015) with confirmed IA were retrospectively reviewed. Significant differences between the OSA and non-OSA groups were determined using a chi-square test...
March 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28336976/the-hall-technique-10-years-on-questions-and-answers
#9
N P T Innes, D J P Evans, C C Bonifacio, M Geneser, D Hesse, M Heimer, M Kanellis, V Machiulskiene, J Narbutaité, I C Olegário, A Owais, M P Araujo, D P Raggio, C Splieth, E van Amerongen, K Weber-Gasparoni, R M Santamaria
It is ten years since the first paper on the Hall Technique was published in the British Dental Journal and almost 20 years since the technique first came to notice. Dr Norna Hall a (now retired) general dental practitioner from the north of Scotland had, for many years, been managing carious primary molar teeth by cementing preformed metal crowns over them, with no local anaesthesia, tooth preparation or carious tissue removal. This first report, a retrospective analysis of Dr Hall's treatments, caused controversy...
March 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28335889/human-papillomavirus-as-prognostic-marker-with-rising-prevalence-in-neck-squamous-cell-carcinoma-of-unknown-primary-a-retrospective-multicentre-study
#10
Lea Schroeder, Paolo Boscolo-Rizzo, Elisa Dal Cin, Salvatore Romeo, Lorena Baboci, Gerhard Dyckhoff, Jochen Hess, Carlota Lucena-Porcel, Anne Byl, Nikolaus Becker, Laia Alemany, Xavier Castellsagué, Miquel Quer, Xavier León, Manuel Wiesenfarth, Michael Pawlita, Dana Holzinger
Patients with neck squamous cell carcinomas of unknown primary tumour (NSCCUP) present with lymph node metastasis without evidence for a primary tumour. Most patients undergo an aggressive multimodal treatment, which induces severe, potentially unnecessary toxicity. Primary tumours of NSCCUP can be hidden in the oropharynx. Human papillomavirus (HPV) is causally involved in a subgroup of oropharyngeal squamous cell carcinomas (OPSCC) associated with early lymph node metastasis and good prognosis. Detection of markers for HPV transformation in NSCCUP could allow focussing on the oropharynx in primary tumour search and could be of value for choice and extent of treatment...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28333704/massive-transfusion-in-cardiac-surgery-the-impact-of-blood-component-ratios-on-clinical-outcomes-and-survival
#11
Meghan Delaney, Paul C Stark, Minhyung Suh, Darrell J Triulzi, John R Hess, Marie E Steiner, Christopher P Stowell, Steven R Sloan
BACKGROUND: Cardiac surgery is the most common setting for massive transfusion in medically advanced countries. Studies of massive transfusion after injury suggest that the ratios of administered plasma and platelets (PLT) to red blood cells (RBCs) affect mortality. Data from the Red Cell Storage Duration Study (RECESS), a large randomized trial of the effect of RBC storage duration in patients undergoing complex cardiac, were analyzed retrospectively to investigate the association between blood component ratios used in massively transfused patients and subsequent clinical outcomes...
March 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28329028/non-equilibrium-assembly-of-microtubules-from-molecules-to-autonomous-chemical-robots
#12
REVIEW
H Hess, Jennifer L Ross
Biological systems have evolved to harness non-equilibrium processes from the molecular to the macro scale. It is currently a grand challenge of chemistry, materials science, and engineering to understand and mimic biological systems that have the ability to autonomously sense stimuli, process these inputs, and respond by performing mechanical work. New chemical systems are responding to the challenge and form the basis for future responsive, adaptive, and active materials. In this article, we describe a particular biochemical-biomechanical network based on the microtubule cytoskeletal filament - itself a non-equilibrium chemical system...
March 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28327983/changing-paradigms-in-the-endovascular-management-of-ruptured-anterior-communicating-artery-aneurysms
#13
Karam Moon, Min S Park, Felipe C Albuquerque, Michael R Levitt, Celene B Mulholland, Cameron G McDougall
BACKGROUND: Approximately 17% of ruptured anterior communicating artery (ACoA) aneurysms were deemed unsuitable for coil embolization during the Barrow Ruptured Aneurysm Trial (BRAT), most commonly due to unfavorable dome-to-neck ratio or small size. OBJECTIVE: To compare patients treated by coil embolization for ruptured ACoA aneurysms during the trial to those treated after the trial to determine whether advances in endovascular techniques have allowed for effective treatment of these lesions...
January 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327151/quantification-of-silver-nanoparticle-uptake-and-distribution-within-individual-human-macrophages-by-fib-sem-slice-and-view
#14
Erik Guehrs, Michael Schneider, Christian M Günther, Piet Hessing, Karen Heitz, Doreen Wittke, Ana López-Serrano Oliver, Norbert Jakubowski, Johanna Plendl, Stefan Eisebitt, Andrea Haase
BACKGROUND: Quantification of nanoparticle (NP) uptake in cells or tissues is very important for safety assessment. Often, electron microscopy based approaches are used for this purpose, which allow imaging at very high resolution. However, precise quantification of NP numbers in cells and tissues remains challenging. The aim of this study was to present a novel approach, that combines precise quantification of NPs in individual cells together with high resolution imaging of their intracellular distribution based on focused ion beam/ scanning electron microscopy (FIB/SEM) slice and view approaches...
March 21, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28325538/lifetime-risk-of-a-diagnosis-of-hiv-infection-in-the-united-states
#15
Kristen L Hess, Xiaohong Hu, Amy Lansky, Jonathan Mermin, Hildegard Irene Hall
PURPOSE: To estimate lifetime risk of receiving an HIV diagnosis in the United States if existing infection rates continue. METHODS: We used mortality, census, and HIV surveillance data for 2010 to 2014 to calculate age-specific probabilities of an HIV diagnosis. The probabilities were applied to a hypothetical cohort of 10 million live births to estimate lifetime risk. RESULTS: Lifetime risk was 1 in 68 for males and 1 in 253 for females...
February 21, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28323831/genetic-assessment-of-age-associated-alzheimer-disease-risk-development-and-validation-of-a-polygenic-hazard-score
#16
Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale
BACKGROUND: Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. METHODS AND FINDINGS: Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer's Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10-5)...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28323286/erythrocyte-glutathione-levels-as-long-term-predictor-of-transition-to-psychosis
#17
S Lavoie, M Berger, M Schlögelhofer, M R Schäfer, S Rice, S-W Kim, J Hesse, P D McGorry, S Smesny, G P Amminger
A high proportion of individuals deemed at elevated risk for psychosis will actually never progress to develop the illness. Pharmaceutical intervention may not be necessary in these cases, and may in fact be damaging depending on the invasiveness of the treatment strategy. This highlights the need for biomarkers that are better able to reliably differentiate between at-risk individuals who will subsequently transition to psychosis and those who will not. Low glutathione (GSH) levels have been observed in schizophrenia and in patients with first-episode psychosis...
March 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28321744/winke-winke-%C3%A2-bin-ich-denn-ein-teletubby
#18
Luise Hess
No abstract text is available yet for this article.
March 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28321471/feasibility-of-in-vivo-18-f-florbetaben-pet-mr-imaging-of-human-carotid-amyloid-%C3%AE
#19
Jan Bucerius, Henryk Barthel, Solveig Tiepolt, Peter Werner, Judith C Sluimer, Joachim E Wildberger, Marianne Patt, Swen Hesse, Hermann-Josef Gertz, Erik A L Biessen, Felix M Mottaghy, Osama Sabri
PURPOSE: Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. (18)F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer's disease (AD). We sought to determine whether specific uptake of (18)F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is associated with clinical cardiovascular disease (CVD) risk factors. METHODS: Carotid (18)F-florbetaben uptake was quantified as the mean of the maximum target-to-background ratio (meanTBRmax) in 40 cognitively impaired subjects (age 68...
March 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28321287/keeping-safe-intra-individual-consistency-in-obstacle-avoidance-behaviour-across-grasping-and-locomotion-tasks
#20
Karina Kangur, Jutta Billino, Constanze Hesse
Successful obstacle avoidance requires a close coordination of the visual and the motor systems. Visual information is essential for adjusting movements in order to avoid unwanted collisions. Yet, established obstacle avoidance paradigms have typically either focused on gaze strategies or on motor adjustments. Here we were interested in whether humans show similar visuomotor sensitivity to obstacles when gaze and motor behaviour are measured across different obstacle avoidance tasks. To this end, we measured participants' hand movement paths when grasping targets in the presence of obstacles as well as their gaze behaviour when walking through a cluttered hallway...
January 2017: I-Perception
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