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https://www.readbyqxmd.com/read/28938401/n-glycomic-profiling-of-pheochromocytomas-and-paragangliomas-separates-metastatic-and-non-metastatic-disease
#1
Helena Leijon, Tuomas Kaprio, Annamari Heiskanen, Tero Satomaa, Jukka O Hiltunen, Markku M Miettinen, Johanna Arola, Caj Haglund
Context: No effective methods for separating primary pheochromocytomas and paragangliomas with metastatic potential are currently available. The identification of specific asparagine-linked glycan (N-glycan) structures, which are associated with metastasized pheochromocytomas and paragangliomas, may serve as a new diagnostic tool. Objective: To identify differences in N-glycomic profiles of primary metastasized and non-metastasized pheochromocytomas and paragangliomas...
August 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28856441/toll-like-receptor-5-and-7-expression-may-impact-prognosis-of-hpv-positive-oropharyngeal-squamous-cell-carcinoma-patients
#2
Lauri Jouhi, Hesham Mohamed, Antti Mäkitie, Satu Maria Remes, Caj Haglund, Timo Atula, Jaana Hagström
A large subset of oropharyngeal squamous cell carcinomas (OPSCCs) is associated with HPV infection and has better outcome than non-viral-related tumors. Various malignancies also carry a role for TLRs, key activators of inflammation and innate immunity. We examined the expression of TLRs in OPSCC, and their association with HPV status and treatment outcome. TLR 5, 7, 9, and p16 were studied by immunohistochemistry and HPV status was detected with in situ hybridization in 202 tumors of consecutively treated OPSCC patients using tissue microarray method...
August 30, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28855268/inflammatory-infiltrates-in-parathyroid-tumors
#3
Felix Haglund, Björn M Hallström, Inga-Lena Nilsson, Anders Höög, C Christofer Juhlin, Catharina Larsson
CONTEXT: Inflammatory infiltrates are sometimes present in solid tumors and may be coupled to clinical behavior or etiology. Infectious viruses contribute to tumorigenesis in a significant fraction of human neoplasias. OBJECTIVE: Characterize inflammatory infiltrates and possible viral transcription in primary hyperparathyroidism. DESIGN: From the period 2007 to 2016, a total of 55 parathyroid tumors (51 adenomas and 4 hyperplasias) with prominent inflammatory infiltrates were identified from more than 2000 parathyroid tumors in the pathology archives, and investigated by immunohistochemistry for CD4, CD8, CD20 and CD45 and scored as +0, +1 or +2...
December 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28843360/prognostic-value-of-primary-tumor-volume-changes-on-kv-cbct-during-definitive-chemoradiotherapy-for-stage-iii-non-small-cell-lung-cancer
#4
P Wald, X Mo, C Barney, D Gunderson, A K Haglund, J Bazan, J Grecula, A Chakravarti, T Williams, D P Carbone, M Xu-Welliver
INTRODUCTION: Kilo-voltage cone beam computed tomography (kV-CBCT) allows for tumor localization and response assessment during definitive chemoradiotherapy for locally advanced non-small cell lung cancer (LA-NSCLC). We hypothesize that significant tumor volume loss occurs early during radiotherapy, and that the extent of volume loss correlates with clinical outcomes. METHODS: 52 patients with LA-NSCLC treated with definitive chemoradiotherapy were reviewed. kV-CBCT images were used to contour primary gross tumor volumes (GTV) at four time points during treatment...
August 23, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28812455/prognostic-factors-for-change-in-self-reported-anxiety-and-depression-in-spondyloarthritis-patients-data-from-the-population-based-spascania-cohort-from-southern-sweden
#5
Jjl Meesters, S Bergman, E Haglund, Lth Jacobsson, I F Petersson, A Bremander
OBJECTIVES: Anxiety and depression symptoms are more common in patients with spondyloarthritis (SpA) than in the general population. This study describes prognostic factors for change in self-reported anxiety and depression over 2 years in a well-defined SpA cohort. METHOD: In 2009, 3716 adult patients from the SpAScania cohort received a postal questionnaire to assess quality of life (QoL) and physical and mental functioning. A follow-up survey was performed in 2011...
August 16, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28768510/educational-needs-in-patients-with-spondyloarthritis-in-sweden-a-mixed-methods-study
#6
Emma Haglund, Ann Bremander, Stefan Bergman, Ingrid Larsson
BACKGROUND: There is a demand for a flexible and individually tailored patient education to meet patients' specific needs and priorities, but this area has seldom been studied in patients with spondyloarthritis (SpA), a family of inflammatory rheumatic diseases. The aim of the present study was to identify needs and priorities in patient education in patients with SpA. A second aim was to investigate patients' experiences and preferences of receiving patient education. METHODS: Data collection included a questionnaire survey with the Educational Needs Assessment Tool (ENAT) and interviews, using a mixed-methods design...
August 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28681694/uchl5-expression-associates-with-improved-survival-in-lymph-node-positive-rectal-cancer
#7
Leena Arpalahti, Jaana Hagström, Harri Mustonen, Mikael Lundin, Caj Haglund, Carina I Holmberg
Colorectal cancer is among the three most common cancer types for both genders, with a rising global incidence. To date, prognostic evaluation is difficult and largely dependent on early detection and successful surgery. UCHL5/Uch37 is an integral part of the protein homeostasis network as one of the three deubiquitinating enzymes associated with the 26S proteasome. Here, we have investigated in colorectal cancer the possible association of UCHL5 tumor expression and patient survival. UCHL5 tumor expression was evaluated by immunohistochemistry in 779 surgically treated colorectal cancer patients from Helsinki University Hospital, Finland, with assessment of clinicopathological parameters and the effect of UCHL5 expression on patient survival...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653876/nuclear-ubiquitin-c-terminal-hydrolase-l5-expression-associates-with-increased-patient-survival-in-pancreatic-ductal-adenocarcinoma
#8
Leena Arpalahti, Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Hanna Seppänen, Caj Haglund, Carina I Holmberg
Pancreatic ductal adenocarcinoma is a lethal disease with an overall 5-year survival of less than 5%. Prognosis among surgically treated patients is difficult and identification of new biomarkers is essential for accurate prediction of patient outcome. As part of one of the major cellular protein degradation systems, the proteasome plays a fundamental role in both physiological and pathophysiological conditions including cancer. The proteasome-associated deubiquitinating enzyme ubiquitin C-terminal hydrolase L5 (UCHL5)/Uch37 is a modulator of proteasome activity with cancer prognostic marker potential...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28600602/early-stage-minor-salivary-gland-adenoid-cystic-carcinoma-has-favourable-prognosis
#9
Hanna Hämetoja, Karoliina Hirvonen, Jaana Hagström, Ilmo Leivo, Kauko Saarilahti, Satu Apajalahti, Caj Haglund, Antti Mäkitie, Leif Bäck
The purpose of the study was to evaluate the long-term outcome of minor salivary and mucous gland (MiSG) adenoid cystic carcinoma (ACC) of the head and neck and to compare the results with earlier reports including our recently published series on major salivary gland (MaSG) ACC. The study comprised 68 MiSG ACCs operated during 1974-2012 at the Helsinki University Hospital, Helsinki, Finland. Medical records and histological samples were reviewed. Our previously published cohort comprising 54 MaSG ACCs during the years from 1974 to 2009 was used for comparison...
June 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28492461/overcoming-barriers-to-initiating-medication-assisted-treatment-for-heroin-use-disorder-in-a-general-medical-hospital-a-case-report-and-narrative-literature-review
#10
Sameer Hassamal, Matthew Goldenberg, Waguih Ishak, Margaret Haglund, Karen Miotto, Itai Danovitch
Deaths due to heroin overdoses are increasing and are the leading cause of death among intravenous heroin users. Although medication-assisted treatment (MAT) improves morbidity and mortality in patients with opioid use disorders, it is underutilized. Most efforts to expand access to MAT have focused on outpatient settings. Although the inpatient medical setting presents a critical opportunity to initiate treatment, general hospitals are often unfamiliar with MAT, creating a number of barriers to its use. In this report, we describe the case of a woman with heroin use disorder who was initiated on buprenorphine maintenance treatment while hospitalized for cardiac disease related to her intravenous heroin use...
May 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28464452/changing-trends-in-the-management-of-the-neck-in-oropharyngeal-squamous-cell-carcinoma
#11
Lauri Jouhi, Timo Atula, Kauko Saarilahti, Jaana Hagström, Caj Haglund, Hesham Mohamed, Antti Mäkitie, Harri Keski-Säntti
BACKGROUND: Treatment for oropharyngeal squamous cell carcinoma (SCC) has changed toward a more oncologic approach. We evaluated treatment of the neck, the incidence of regional recurrences, and factors associated with regional recurrence during the treatment approach transition period in patients with regional lymph node metastasis. METHODS: All patients with oropharyngeal SCC diagnosed at the Helsinki University Hospital during 2000-2009 were analyzed for clinicopathological factors, treatment, p16 expression, and regional recurrence...
July 2017: Head & Neck
https://www.readbyqxmd.com/read/28362521/a-nationwide-study-on-parathyroid-carcinoma
#12
Eeva M Ryhänen, Helena Leijon, Saara Metso, Eija Eloranta, Pirkko Korsoff, Petteri Ahtiainen, Päivi Kekäläinen, Marjo Tamminen, Raija Ristamäki, Otto Knutar, Eliisa Löyttyniemi, Leo Niskanen, Mika Väisänen, Ilkka Heiskanen, Matti J Välimäki, Markku Laakso, Caj Haglund, Johanna Arola, Camilla Schalin-Jäntti
BACKGROUND: Parathyroid carcinoma (PC) is rare and diagnostically challenging. Reported outcomes are rather poor and the incidence might be increasing. MATERIAL AND METHODS: We performed a nationwide study on all cases (n= 32) diagnosed in 2000-2011 in Finland, and compared clinical and histopathological characteristics and outcome to atypical parathyroid (APA; n= 28) and parathyroid adenomas (PA; n= 72). The incidence in years 1955-1999 was compared to that in 2000-2013...
July 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28321274/risk-factors-for-hepatocellular-carcinoma-in-cirrhosis-due-to-nonalcoholic-fatty-liver-disease-a-multicenter-case-control-study
#13
Kathleen E Corey, Samer Gawrieh, Andrew S deLemos, Hui Zheng, Andrew E Scanga, Jennifer W Haglund, Jorge Sanchez, Christopher J Danford, Megan Comerford, Krista Bossi, Samina Munir, Naga Chalasani, Julia Wattacheril
AIM: To identify risk factors associated with hepatocellular carcinoma (HCC), describe tumor characteristics and treatments pursed for a cohort of individuals with nonalcoholic steatohepatitis (NASH) cirrhosis. METHODS: We conducted a retrospective case-control study of a well-characterized cohort of patients among five liver transplant centers with NASH cirrhosis with (cases) and without HCC (controls). RESULTS: Ninety-four cases and 150 controls were included...
March 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28278299/combination-treatment-with-6-mercaptopurine-and-allopurinol-in-hepg2-and-hek293-cells-effects-on-gene-expression-levels-and-thiopurine-metabolism
#14
Sofie Haglund, Svante Vikingsson, Sven Almer, Jan Söderman
Combination treatment with low-dose thiopurine and allopurinol (AP) has successfully been used in patients with inflammatory bowel disease with a so called skewed thiopurine metabolite profile. In red blood cells in vivo, it reduces the concentration of methylated metabolites and increases the concentration of the phosphorylated ones, which is associated with improved therapeutic efficacy. This study aimed to investigate the largely unknown mechanism of AP on thiopurine metabolism in cells with an active thiopurine metabolic pathway using HepG2 and HEK293 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28257418/epidemiology-of-pediatric-surgical-needs-in-low-income-countries
#15
Elissa K Butler, Tu M Tran, Neeraja Nagarajan, Joseph Canner, Anthony T Fuller, Adam Kushner, Michael M Haglund, Emily R Smith
OBJECTIVE: According to recent estimates, at least 11% of the total global burden of disease is attributable to surgically-treatable diseases. In children, the burden is even more striking with up to 85% of children in low-income and middle-income countries (LMIC) having a surgically-treatable condition by age 15. Using population data from four countries, we estimated pediatric surgical needs amongst children residing in LMICs. METHODS: A cluster randomized cross-sectional countrywide household survey (Surgeons OverSeas Assessment of Surgical Need) was done in four countries (Rwanda, Sierra Leone, Nepal and Uganda) and included demographics, a verbal head to toe examination, and questions on access to care...
2017: PloS One
https://www.readbyqxmd.com/read/28122246/glioblastoma-cell-malignancy-and-drug-sensitivity-are-affected-by-the-cell-of-origin
#16
Yiwen Jiang, Voichita Dana Marinescu, Yuan Xie, Malin Jarvius, Naga Prathyusha Maturi, Caroline Haglund, Sara Olofsson, Nanna Lindberg, Tommie Olofsson, Caroline Leijonmarck, Göran Hesselager, Irina Alafuzoff, Mårten Fryknäs, Rolf Larsson, Sven Nelander, Lene Uhrbom
The identity of the glioblastoma (GBM) cell of origin and its contributions to disease progression and treatment response remain largely unknown. We have analyzed how the phenotypic state of the initially transformed cell affects mouse GBM development and essential GBM cell (GC) properties. We find that GBM induced in neural stem-cell-like glial fibrillary acidic protein (GFAP)-expressing cells in the subventricular zone of adult mice shows accelerated tumor development and produces more malignant GCs (mGC1GFAP) that are less resistant to cancer drugs, compared with those originating from more differentiated nestin- (mGC2NES) or 2,'3'-cyclic nucleotide 3'-phosphodiesterase (mGC3CNP)-expressing cells...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/27974676/in-vitro-and-in-vivo-anti-leukemic-activity-of-the-peptidase-potentiated-alkylator-melflufen-in-acute-myeloid-leukemia
#17
Sara Strese, Saadia Bashir Hassan, Ebba Velander, Caroline Haglund, Martin Höglund, Rolf Larsson, Joachim Gullbo
The novel aminopeptidase potentiated alkylating agent melflufen, was evaluated for activity in acute myeloid leukemia in a range of in vitro models, as well as in a patient derived xenograft study. All tested AML cell lines were highly sensitive to melflufen while melphalan was considerably less potent. In the HL-60 cell line model, synergy was observed for the combination of melflufen and cytarabine, an interaction that appeared sequence dependent with increased synergy when melflufen was added before cytarabine...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/27879501/introducing-allergenic-food-into-infants-diets-systematic-review
#18
REVIEW
Katelin Larson, Jessica McLaughlin, Mallory Stonehouse, Brittany Young, Kristin Haglund
PURPOSE: The purpose of this systematic review was to explore the association between timing of introduction of potentially allergenic foods to infants and development of food allergies. METHODS: CINAHL, Medline, PubMed, Science Direct, and Web of Science were searched using the terms solid food, complementary food, or infant feeding combined with allergy or hypersensitivity for articles published in English in 2000 or later. Inclusion criteria were 1) primary research articles with 2) a focus on association between introduction of complementary foods including potentially allergenic foods into diets of infants less than 12 months of age and development of food allergies...
March 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/27804311/systemic-matrix-metalloproteinase-8-response-in-chronic-tonsillitis
#19
Taru Ilmarinen, Triin Lont, Jaana Hagström, Taina Tervahartiala, Timo Sorsa, Caj Haglund, Eva Munck-Wickland, Torbjörn Ramqvist, Tina Dalianis, Leena-Maija Aaltonen
The development of several life-long diseases, such as coronary heart disease, is affected by low-grade systemic inflammation. Data on the potential long-term health effects of chronic tonsillitis are limited. Many inflammatory conditions present with enhanced systemic matrix metalloproteinase (MMP)-8 response. In head and neck cancer, high plasma level of tissue inhibitor of metalloproteinase (TIMP)-1 predicts poor prognosis. We analyzed S-MMP-8 with immunofluorometric assay and S-TIMP-1 with an immunosorbent assay in 175 consecutive patients undergoing tonsillectomy for benign tonsillar disease, and in 33 control patients with tonsillar squamous cell carcinoma...
April 2017: Infectious Diseases
https://www.readbyqxmd.com/read/27747285/endoscopic-sphincterotomy-and-risk-of-cholangiocarcinoma-a-population-based-cohort-study-in-finland-and-sweden
#20
Cecilia Strömberg, Camilla Böckelman, Huan Song, Weimin Ye, Eero Pukkala, Caj Haglund, Magnus Nilsson
Background and study aims: Elevated long-term risk of cholangiocarcinoma is reported after endoscopic sphincterotomy (ES), but in a previous study we found a trend towards a decreased risk. The aim of this study was to evaluate the association in a larger cohort with a longer follow-up. Patients and methods: Data concerning all patients having had an inpatient endoscopic retrograde cholangiopancreatography (ERCP) were collected from the hospital discharge registries of Finland and Sweden. Incident cases of malignancy were identified through linkage to the nationwide Cancer Registries...
October 2016: Endoscopy International Open
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