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Atrial fibrilation and cancer

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https://www.readbyqxmd.com/read/29139276/preventing-stroke-and-assessing-risk-in-women
#1
Tracey Keteepe-Arachi, Sanjay Sharma
Ischaemic stroke is rare in premenopausal women but risk increases with advancing age and doubles in the ten years following the menopause. Up to the age of 75 years men have a 25% higher risk of suffering a stroke compared with women. However, the increased life expectancy of women ultimately results in a higher overall incidence. Twice as many women die from stroke compare with breast cancer. Women with cerebrovascular disease are more likely to present with atypical symptoms than men. Altered mental status (including unresponsiveness, confusion and behavioural change) is the most common nonconventional symptom, and is reported by 23% of women compared with 15% of men...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29134538/postoperative-atrial-fibrillation-is-less-frequent-in-pulmonary-segmentectomy-compared-with-lobectomy
#2
Takuya Ueda, Kenji Suzuki, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh
OBJECTIVE: The aim of this study was to elucidate the characteristics and predictors of postoperative atrial fibrillation (POAF) from the standpoint of surgical mode. METHODS: Retrospective analysis was carried out on 607 patients who underwent lobectomy or segmentectomy for clinical stage IA lung cancer. We investigated the clinical factors to determine the predictors of the development of POAF. RESULTS: Of the 607 patients, 443 underwent lobectomy, and 164 underwent segmentectomy...
November 13, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29127240/the-association-of-severe-hypoglycemia-with-incident-cardiovascular-events-and-mortality-in-adults-with-type-2-diabetes
#3
Alexandra K Lee, Bethany Warren, Clare J Lee, John W McEvoy, Kunihiro Matsushita, Elbert S Huang, A Richey Sharrett, Josef Coresh, Elizabeth Selvin
OBJECTIVE: There is suggestive evidence linking hypoglycemia with cardiovascular disease, but few data have been collected in a community-based setting. Information is lacking on individual cardiovascular outcomes and cause-specific mortality. RESEARCH DESIGN AND METHODS: We conducted a prospective cohort analysis of 1,209 participants with diagnosed diabetes from the Atherosclerosis Risk in Communities (ARIC) Study (analytic baseline, 1996-1998). Severe hypoglycemic episodes were identified using first position ICD-9 codes from hospitalizations, emergency department visits, and ambulance calls through 2013...
November 10, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29126922/the-unrecognized-role-of-tumor-suppressor-genes-in-atrial-fibrillation
#4
REVIEW
Liang Mao, Wenjun Huang, Ping Zou, Xitong Dang, Xiaorong Zeng
Epidemiogical evidence has shown that the incidence of atrial fibrillation in tumor patients is higher than non-tumor patients and general population. The potential risk factors predisposing tumor patients to atrial fibrillation include advanced age, comorbidities, direct anatomic local occupying effect of tumors in the heart or adjacent organs, paraneoplastic manifestations of some tumors, tumor-induced dys-regulation of metabolism, radio-, bio- and chemo-therapeutics, disturbance of autonomous nerve system because of physical pain and psychological sufferings, chronic inflammation typical of most tumors, and surgical interventions among others...
November 7, 2017: Gene
https://www.readbyqxmd.com/read/29125921/management-of-anticoagulation-in-patients-with-prostate-cancer-receiving-enzalutamide
#5
Joseph J Shatzel, Molly M Daughety, Sven R Olson, Tomasz M Beer, Thomas G DeLoughery
Enzalutamide, a novel, oral androgen receptor antagonist used for the treatment of metastatic, castration-resistant prostate cancer, has been shown to improve overall and progression-free survival, prolong time to initiation of chemotherapy, reduce skeletal-related events, and carry a favorable adverse effect profile. Metastatic prostate cancer is a disease of older men, a population with an increased incidence of medical comorbidities warranting anticoagulation. Prostate cancer itself, along with some of its therapies, is also prothrombotic...
November 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29114736/association-of-warfarin-use-with-lower-overall-cancer-incidence-among-patients-older-than-50-years
#6
Gry S Haaland, Ragnhild S Falk, Oddbjørn Straume, James B Lorens
Importance: In cancer models, warfarin inhibits AXL receptor tyrosine kinase-dependent tumorigenesis and enhances antitumor immune responses at doses not reaching anticoagulation levels. This study investigates the association between warfarin use and cancer incidence in a large, unselected population-based cohort. Objective: To examine the association between warfarin use and cancer incidence. Design, Setting, and Participants: This population-based cohort study with subgroup analysis used the Norwegian National Registry coupled with the Norwegian Prescription Database and the Cancer Registry of Norway...
November 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29114598/long-term-survival-and-toxicity-outcomes-of-intensity-modulated-radiation-therapy-for-the-treatment-of-esophageal-cancer-a-large-single-institutional-cohort-study
#7
Anhui Shi, Zhongxing Liao, Pamela K Allen, Linus Ho, Mariela Blum Murphy, Dipen M Maru, Stephen G Swisher, Wayne L Hofstetter, Reza J Mehran, James D Cox, Ritsuko Komaki, Steven H Lin
Purpose: In patients with esophageal cancer (EC), intensity modulated radiation therapy (IMRT) improves dose sparing to the heart and lung, with some evidence showing clinical benefit. Herein, we report our cumulative clinical experience with the use of IMRT for EC. Methods and materials: This is a retrospective analysis of 587 patients with nonmetastatic EC who were treated consecutively with IMRT from January 2004 to June 30, 2013. All patients with stage I-IVA (American Joint Committee on Cancer 2002) received concurrent chemoradiation therapy either preoperatively or definitively...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29067225/brain-tumor-causing-atrial-fibrillation-in-an-otherwise-healthy-patient
#8
Nilesh H Pawar, Farhad F Vasanwala, Melvin Chua
We report a case of a 57-year-old man who presented with an episode of syncope resulting in an accident. On presentation, he was found to have atrial fibrillation (AF). A brain imaging done to exclude intracranial hemorrhage revealed a brain tumor instead. Recently, AF has been used as a marker for occult cancer. Thus, we hypothesize that AF in our patient was a result of the existing brain tumor and not simply a coincidence. AF may help in diagnosing brain tumors in asymptomatic or oligosymptomatic patients at an early stage, decreasing mortality and morbidity significantly...
August 23, 2017: Curēus
https://www.readbyqxmd.com/read/29056955/comparison-of-long-term-outcome-between-patients-aged-65-years-vs-%C3%A2-65-years-after-atrial-fibrillation-ablation
#9
Zsuzsanna Kis, Anna Me Noten, Mihran Martirosyan, Astrid A Hendriks, Rohit Bhagwandien, Tamas Szili-Torok
BACKGROUND: Atrial fibrillation (AF) is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to compare the long-term outcome data of patients < 65 years vs. ≥ 65 years who underwent catheter ablation (CA) for drug-refractory AF. METHODS: Consecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completed a five-year of follow-up were divided into two groups: patients aged < 65 years into group 1, and patients aged ≥ 65 into group 2...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29052104/anticoagulation-prescribing-patterns-in-patients-with-cancer
#10
Elaine Xiang, Tania Ahuja, Veronica Raco, Frank Cirrone, David Green, John Papadopoulos
Cancer is a known hypercoagulable state that leads to an increased risk of venous thromboembolism (VTE). Low molecular weight heparin remains the preferred anticoagulant for VTE in patients with cancer over vitamin K antagonist. However, the preferred anticoagulant in prevention of stroke and systemic embolism in atrial fibrillation (AF) in patients with cancer has yet to be determined. The direct oral anticoagulants (DOACs) are increasingly being utilized; however their role in cancer has only recently been investigated...
October 19, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29049919/comparison-of-cha2ds2-vasc-chads2-and-hatch-scores-for-the-prediction-of-new-onset-atrial-fibrillation-in-cancer-patients-a-nationwide-cohort-study-of-760-339-study-participants-with-competing-risk-analysis
#11
Wei-Syun Hu, Cheng-Li Lin
BACKGROUND AND AIMS: The current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer. METHODS: Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29046091/crossing-the-bridge-to-vats-lobectomy
#12
P Tcherveniakov, C Bogdan, N Chaudhuri
Introduction The impact of the introduction of video assisted thoracoscopic surgery (VATS) on the management of lung cancer 20 years ago has been well documented. However, the uptake of VATS lobectomy in surgical practice worldwide has been slower than expected. We believe that this is partly due to a lack of consensus on how this procedure should be integrated into training programmes. We present our initial experience with a newly developed training model, which could help bridge the divide between open and VATS lobectomy...
October 19, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29040554/frailty-syndrome-an-emerging-clinical-problem-in-the-everyday-management-of-clinical-arrhythmias-the-results-of-the-european-heart-rhythm-association-survey
#13
Stefano Fumagalli, Tatjana S Potpara, Torben Bjerregaard Larsen, Kristina H Haugaa, Dan Dobreanu, Alessandro Proclemer, Nikolaos Dagres
The age of patients presenting with complex arrhythmias is increasing. Frailty is a multifaceted syndrome characterized by an increased vulnerability to stressors and a decreased ability to maintain homeostasis. The prevalence of frailty is associated with age. The aims of this European Heart Rhythm Association (EHRA) EP Wire survey were to evaluate the proportion of patients with frailty and its influence on the clinical management of arrhythmias. A total of 41 centres-members of the EHRA Electrophysiology Research Network-in 14 European countries completed the web-based questionnaire in June 2017...
November 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29033049/usefulness-of-chads2-and-cha2ds2-vasc-scores-for-stroke-prediction-in-patients-with-cancer-and-atrial-fibrillation
#14
Rushad Patell, Alejandra Gutierrez, Lisa Rybicki, Alok A Khorana
Stroke prediction scores have not been validated in patients with cancer and atrial fibrillation (AF). We aimed to identify unique risk factors and evaluate validity of CHADS2 and CHA2DS2-VASc scores to predict risk of stroke and mortality. A retrospective review of all patients with cancer with pre-existing AF presenting from 2008 to 2014 was performed. Outcomes included ischemic stroke and mortality. Prognostic factors were identified with Fine and Gray regression for stroke and Cox proportional hazards analysis for survival...
September 20, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29018538/replacement-of-warfarin-with-a-novel-oral-anticoagulant-in-endoscopic-mucosal-resection-a-multicentre-open-label-randomised-controlled-trial
#15
Takuya Yamada, Akiko Kada, Toshio Uraoka, Toshio Kuwai, Noriko Watanabe, Yoshihiro Sasaki, Katsuhiro Mabe, Yasuo Takahashi, Takashi Kagaya, Toshihisa Kimura, Hiroshige Hamada, Akiko M Saito, Naohiko Harada
INTRODUCTION: This randomised controlled trial aims to compare the efficacy of warfarin replacement with apixaban without postoperative resumption of heparin with that of conventional heparin bridging in patients taking warfarin and scheduled to undergo endoscopic mucosal resection (EMR): specifically, by checking for reduction in proportion of postoperative bleeding following EMR. METHODS AND ANALYSIS: The multicentre, open-label randomised parallel-group, controlled intervention study regards patients taking warfarin who are scheduled to undergo colon EMR...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28975092/self-limited-membranous-nephropathy-after-intravitreal-bevacizumab-therapy-for-age-related-macular-degeneration
#16
Gebran Khneizer, Ahmad Al-Taee, Bahar Bastani
BACKGROUND: Monoclonal antibodies targeting vascular endothelial growth factor (VEGF), such as bevacizumab, are administered intravitreally for the treatment of wet or exudative age-related macular degeneration (ARMD). Systemic use of bevacizumab has been linked to a wide range of renal adverse effects including proteinuria and hypertension. CASE PRESENTATION: We present the case of a 77-year-old Caucasian male with a past medical history of hypertension, vitamin D deficiency and paroxysmal atrial fibrillation who presented to primary care clinic with a 2-week history of bilateral lower extremity edema, 2 months after completing four monthly intravitreal injections of bevacizumab for ARMD...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28964830/causal-effects-of-cardiovascular-risk-factors-on-onset-of-major-age-related-diseases-a-time-to-event-mendelian-randomization-study
#17
Liang He, Irina Culminskaya, Yury Loika, Konstantin G Arbeev, Olivia Bagley, Matt Duan, Anatoliy I Yashin, Alexander M Kulminski
BACKGROUNDS: Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS: We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts to investigate dynamic causal effects of cardiovascular disease risk factors including body mass index (BMI), systolic blood pressure (SBP), and lipids on the age-at-onset of age-related diseases...
September 28, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28962198/analysis-of-risk-factors-for-post-operative-complications-and-prognostic-predictors-of-disease-recurrence-following-definitive-treatment-of-patients-with-esophageal-cancer-from-two-medical-centers-in-northwest-china
#18
Jichang Wang, Boxiang Zhang, Jinying Meng, Guodong Xiao, Xiang Li, Gang Li, Sida Qin, Ning Du, Jia Zhang, Jing Zhang, Chongwen Xu, Shou-Ching Tang, Rui Liang, Hong Ren, Xin Sun
Evaluating the clinicopathological features of patients receiving definitive treatment for esophageal cancer may facilitate the identification of patterns and factors associated with post-operative complications, and enable the development of a surveillance strategy for surviving patients at a higher risk of disease recurrence. In the present study, clinical data from 579 patients with esophageal cancer that underwent radical resection of esophagus were collected. These patients were admitted to two medical centers in Northwest China, and information regarding the presence or absence of basic chronic diseases and post-operative results were retrospectively analyzed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28943552/aortic-aneurysm-associated-disseminated-intravascular-coagulation-dic-that-responded-well-to-a-switch-from-warfarin-to-rivaroxaban
#19
Yasuko Kadohira, Shinya Yamada, Erika Matsuura, Tomoe Hayashi, Eriko Morishita, Shinji Nakao, Hidesaku Asakura
We describe a case in which uncontrolled chronic disseminated intravascular coagulation (DIC) caused by an aortic aneurysm that was exacerbated by chemotherapy for lung cancer, showed dramatic improvement when warfarin, which was being administered for atrial fibrillation, was replaced by rivaroxaban, a direct oral anticoagulant (DOAC). The present case is interesting because a DOAC was effective in treating DIC due to an aortic aneurysm, whereas warfarin, another oral anticoagulant, was ineffective. In controlling DIC, it is important to inhibit activated coagulation factors such as thrombin and activated factor X, rather than the coagulation factors, which act as substrates...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#20
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
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