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Atrial fibrilation and cancer

K Belghazi, R E Pouw, Cmt Sondermeijer, S L Meijer, E J Schoon, A D Koch, Blam Weusten, Jjghm Bergman
Background: The 360 Express balloon catheter (360 Express) has the ability to self-adjust to the esophageal lumen, ensuring optimal tissue contact. Objective: The objective of this article is to evaluate the efficacy and safety of the 360 Express for radiofrequency ablation (RFA) treatment of Barrett's esophagus (BE). Methods: BE patients with low-grade dysplasia (LGD), high-grade dysplasia (HGD) or early cancer (EC) were included. Visible lesions were removed by endoscopic resection (ER) prior to RFA...
August 2018: United European Gastroenterology Journal
Daniele Bernardi, Emanuele Asti, Davide Ferrari, Luigi Bonavina
BACKGROUND Perforated gastric cancer accounts for less than 1% of patients who present with an acute abdomen and for up to 16% of all gastric perforations. A two-stage laparoscopic procedure may be the therapeutic strategy of choice in selected patients, and adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) can reduce the incidence of peritoneal recurrence. A rare case of subphrenic abscess and gastric perforation due to carcinoma of the gastric fundus, followed by two-stage gastrectomy and adjuvant HIPEC is presented...
September 19, 2018: American Journal of Case Reports
Sean T Chen, Anne S Hellkamp, Richard C Becker, Scott D Berkowitz, Günter Breithardt, Keith A A Fox, Werner Hacke, Jonathan L Halperin, Graeme J Hankey, Kenneth W Mahaffey, Christopher C Nessel, Jonathan P Piccini, Daniel E Singer, Manesh R Patel, Chiara Melloni
Aims: The management of anticoagulation therapy in patients with atrial fibrillation (AF) and cancer is challenging due to increased thrombotic and bleeding risks. We sought to determine the safety and efficacy of rivaroxaban in patients with AF and a history of cancer. Methods and Results: ROCKET AF randomized 14,264 patients with AF to rivaroxaban or warfarin with a median follow-up of 1.9 years. Cox regression models were used to assess the association between cancer history and clinical outcomes, and the relative treatment effect of rivaroxaban versus warfarin in these patients...
September 14, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
Yuji Okura, Tsugumi Takayama, Kazuyuki Ozaki, Hiroshi Tanaka, Hiroshi Seki, Tatsuya Takenouchi, Nobuaki Sato, Tohru Minamino
BACKGROUND: Cardiovascular disease (CVD) and cancer are major causes of death in Japan. As most CVDs are chronic and often aggravate, long-term follow-up is necessary. Although some cancer patients and survivors have CVD, its prognostic significance and prevalence are unknown. Therefore, we conducted a retrospective study at our center to determine the prevalence of cancer patients with CVD. METHODS: In 2015, our 10-year (2005-2014) cancer registry was summarized...
September 14, 2018: International Journal of Clinical Oncology
Luke C Pilling, Janice L Atkins, George A Kuchel, Luigi Ferrucci, David Melzer
Higher Red Blood Cell Distribution Width (RDW or anisocytosis) predicts incident coronary artery disease (CAD) plus all-cause and cardiovascular mortality, but its predictive value for other common diseases in healthy volunteers is less clear. We aimed to determine the shorter and longer term associations between RDW and incident common conditions in participants free of baseline disease, followed for 9 years. We undertook a prospective analysis of RDW% using 240,477 healthy UK Biobank study volunteers aged 40-70 years at baseline, with outcomes ascertained during follow-up (≤9 years)...
2018: PloS One
Suzanne Lydiard, Vincent Caillet, Svenja Ipsen, Ricky T O'Brien, Oliver Blanck, Per Rugaard Poulsen, Jeremy Todd Booth, Paul J Keall
Stereotactic arrhythmia radioablation (STAR) is an emerging treatment option for atrial fibrillation (AF). However, it faces possibly the most challenging motion compensation scenario: both respiratory and cardiac motion. MLC tracking is clinically used for lung cancer treatments but its capabilities with intracardiac targets is unknown. We report the first experimental results of MLC tracking for intracardiac targets. 
 Methods: Five AF STAR plans of varying complexity were created. All delivered 5×10Gy to both pulmonary vein antra...
September 6, 2018: Physics in Medicine and Biology
Takashi Okabe, Hironori Ueno, Shinya Fujita, Toshiya Kagoo, Saigen Boku, Takahiro Yano, Akihiro Yokoyama
Acquired factor V (FV) inhibitor is a rare disorder. Herein we report a case of an 82-year-old Japanese woman with FV inhibitor exhibiting a pseudo decline in the activities of the multiple coagulation factors. After rectal cancer surgery, she received antibiotic therapy for wound infection. As prothrombin and activated partial thromboplastin time was prolonged, heparin for atrial fibrillation was discontinued without improvement. Coagulation factor activity assays revealed deficiencies in II, V, VII, VIII, IX, X, XI, and XII factor activities; in particular, the FV activity was markedly decreased to <1%...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Hyun-Il Gil, Junsu Choe, Byeong-Ho Jeong, Sang-Won Um, Kyeongman Jeon, Joo-Yong Hahn, Hojoong Kim, O Jung Kwon, Yoon Soo Chang, Kyungjong Lee
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) may be necessary for patients with incidental lung cancer during or after coronary intervention. Although EBUS-TBNA is quite safe, the safety in patients who recently received percutaneous coronary intervention (PCI) has not been demonstrated. The aim of this study was to assess the safety of EBUS-TBNA in patients with lung cancer who underwent PCI within one year. METHODS: We retrospectively reviewed the medical records of 24 patients who underwent EBUS-TBNA within one year after PCI between May 2009 and June 2017...
August 29, 2018: Thoracic Cancer
Charlotte J Bai, Nidhi Madan, Shaza Alshahrani, Neelum T Aggarwal, Annabelle Santos Volgman
PURPOSE OF REVIEW: Atrial fibrillation (AF) is a growing health problem worldwide. While the disease plagues both men and women, this arrhythmia does not affect both sexes equally. Women are more likely to have major adverse outcomes such as stroke and its sequela; however, recent data on stroke prevention show improving outcomes. The purpose of this review of the recent literature is to summarize important updates on risk scores and management of patients with AF. RECENT FINDINGS: It has been well known that women have a higher risk of strokes than men when untreated or when treated with warfarin...
August 27, 2018: Current Treatment Options in Cardiovascular Medicine
Vincenzo Russo, Roberta Bottino, Anna Rago, Pierpaolo Di Micco, Antonio D' Onofrio, Biagio Liccardo, Paolo Golino, Gerardo Nigro
Atrial fibrillation (AF) is commonly diagnosed in the setting of active cancer. Because of an increased risk of either thromboembolic events or bleeding, the decision to initiate therapeutic anticoagulation in patients with active cancer can be challenging. Moreover, little is still known about the optimal anticoagulation therapy in the setting of AF and cancer, and no guidelines are as yet available. Considering that nonvitamin K antagonist oral anticoagulants (NOACs) are recommended as alternatives to vitamin K antagonists for stroke prevention in AF patients with CHA2 DS2- VASc score ≥2, the authors performed a systematic review of the current literature to describe the efficacy and safety of NOACs in AF patients with malignancy...
August 17, 2018: Seminars in Thrombosis and Hemostasis
Nikolaos A Papakonstantinou, Charalambos Zisis, Charikleia Kouvidou, Grigoris Stratakos
Radiofrequency ablation is an effective treatment for atrial fibrillation. Pulmonary vein stenosis/occlusion is one of its rare complications. Herein, the case of a 50-year-old man with hemoptysis and migratory pulmonary infiltrations after transcatheter radiofrequency ablation for atrial fibrillation is presented. Initially, pneumonia, interstitial pulmonary disease, or lung cancer was suspected, but wedge resection revealed hemorrhagic infiltrations. Chest computed tomography pulmonary angiography detected no left superior pulmonary vein due to its total occlusion, and left upper lobectomy was performed...
August 2018: Korean Journal of Thoracic and Cardiovascular Surgery
Amit V Khera, Mark Chaffin, Krishna G Aragam, Mary E Haas, Carolina Roselli, Seung Hoan Choi, Pradeep Natarajan, Eric S Lander, Steven A Lubitz, Patrick T Ellinor, Sekar Kathiresan
A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one important approach is to stratify individuals based on inherited DNA variation1 . Proposed clinical applications have largely focused on finding carriers of rare monogenic mutations at several-fold increased risk. Although most disease risk is polygenic in nature2-5 , it has not yet been possible to use polygenic predictors to identify individuals at risk comparable to monogenic mutations...
September 2018: Nature Genetics
Lina Ya'qoub, Shelby Larson, Matthew Deedy, Ibrahim M Saeed
The heart is a destination for metastases of various types of primary tumors, with lung, breast, melanoma, and mesothelioma being the most common types. Recurrent isolated cardiac metastasis presenting as a cavitary mass is rare. We present a case of recurrent isolated cavitary metastatic mass to the right atrium in a patient with the history of breast cancer who presented with new-onset atrial fibrillation. The patient successfully received radiation therapy with the resolution of the mass confirmed on repeat echocardiography...
August 12, 2018: Echocardiography
Ageliki Laina, Aikaterini Gatsiou, Georgios Georgiopoulos, Kimon Stamatelopoulos, Konstantinos Stellos
Since our knowledge on structure and function of messenger RNA (mRNA) has expanded from merely being an intermediate molecule between DNA and proteins to the notion that RNA is a dynamic gene regulator that can be modified and edited, RNA has become a focus of interest into developing novel therapeutic schemes. Therapeutic modulation of RNA molecules by DNA- and RNA-based therapies has broadened the scope of therapeutic targets in infectious diseases, cancer, neurodegenerative diseases and most recently in cardiovascular diseases as well...
2018: Frontiers in Physiology
Maria Cristina Vedovati, Michela Giustozzi, Paolo Verdecchia, Lucia Pierpaoli, Serenella Conti, Melina Verso, Francesco Di Filippo, Emanuela Marchesini, Giulio Bogliari, Giancarlo Agnelli, Cecilia Becattini
BACKGROUND: Limited data are available on the use of direct oral anticoagulants (DOACs) in patients with cancer and atrial fibrillation (AF). METHODS: Consecutive patients with non-valvular AF treated with DOACs were enrolled in a prospective cohort with the aim of evaluating thromboembolic (ischemic stroke or transient ischemic attack or systemic embolism) and major bleeding (MB) events according to presence and type of cancer. The risk of study outcomes over time was compared using Kaplan-Meier method and log-rank test or Cox proportional hazards regression...
July 29, 2018: International Journal of Cardiology
Clare L Atzema, Paul Dorian, Jiming Fang, Jack V Tu, Douglas S Lee, Alice S Chong, Peter C Austin
BACKGROUND: In previous work, we derived and validated a tool that predicts 30-day mortality in emergency department atrial fibrillation (AF) patients. The objective of this study was to derive and validate a tool that predicts a composite of 30-day mortality and return cardiovascular hospitalizations. METHODS: This retrospective cohort study at 24 emergency departments in Ontario, Canada, included patients with a primary diagnosis of AF who were seen between April 2008 and March 2009...
September 2018: American Heart Journal
Kangjie Xie, Wen Zhang, Jun Fang, Ye Guo, Man Fang, Zewu Ding, Yuqian Hu, Weifeng Yu, Fugui Li
The aim of this prospective observational study was to screen for risk factors of intraoperative atrial fibrillation (AF) during noncardiac thoracic surgery. The study was conducted as a single-institution study in Zhejiang Cancer Hospital, Hangzhou, China. All the participants were patients with cancer scheduled for thoracotomy.This study was conducted from July 2013 to August 2016 and included 144 patients scheduled for thoracotomy under general anesthesia. We collected the patients' demographic and perioperative medical data in our hospital...
July 2018: Medicine (Baltimore)
Shinji Ito, Koichi Kikuchi, Akihiro Ueda, Ryunosuke Nagao, Toshiki Maeda, Kenichiro Murate, Sayuri Shima, Yasuaki Mizutani, Yoshiki Niimi, Tatsuro Mutoh
Background: The development of acute multiple embolic infarctions (AMEI) resulting from cancer is known as Trousseau's syndrome (TS). At present, however, there is no good marker for predicting the prognosis of TS patients. In the present study, we evaluated the use of serial D-dimer levels as a prognostic marker for TS. Methods: This retrospective cohort study included 1,409 consecutive acute ischemic stroke patients. We selected a group of patients with TS showing AMEI ( n = 38; TS group) and a group of patients with atrial fibrillation (Af) and AMEI ( n = 35; Af group) as controls...
2018: Frontiers in Neurology
Husam Abdel-Qadir, Jiming Fang, Douglas S Lee, Jack V Tu, Eitan Amir, Peter C Austin, Geoffrey M Anderson
BACKGROUND: Ignoring competing risks in time-to-event analyses can lead to biased risk estimates, particularly for elderly patients with multimorbidity. We aimed to demonstrate the impact of considering competing risks when estimating the cumulative incidence and risk of stroke among elderly atrial fibrillation patients. METHODS AND RESULTS: Using linked administrative databases, we identified patients with atrial fibrillation aged ≥66 years discharged from hospital in ON, Canada between January 1, 2007, and March 31, 2011...
July 2018: Circulation. Cardiovascular Quality and Outcomes
Shabir Ahmad Ganai, Zeenat Farooq, Shahid Banday, Mohammad Altaf
AIM: Aberrant activity of class I histone deacetylases (HDACs) has strong implications for various cancers. Targeting these HDACs with synthetic HDAC inhibitors has shown significant side effects such as atrial fibrillation and QT prolongation emphasizing the need of natural inhibitors as substitutes to synthetic ones. RESULTS: The binding propensity of the two plant-derived inhibitors apigenin and luteolin towards class I HDAC isoforms was checked using extra-precision molecular docking and implicit solvation MMGBSA...
August 1, 2018: Future Medicinal Chemistry
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