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Atrial fibrilation and cancer

Beomseok Suh, Dong Wook Shin, Youngmin Park, Hyunsun Lim, Jae Moon Yun, Sun Ok Song, Jin-Ho Park, Belong Cho, Eliseo Guallar
OBJECTIVE: Many thyroid cancer patients are exposed to long-term thyroid stimulating hormone (TSH) suppression, in many cases as lifetime treatment, and are consequently subjected to risk for cardiovascular disease. We investigated incidence of coronary heart disease (CHD) and ischemic stroke among thyroid cancer patients compared to matched control subjects. DESIGN: Retrospective cohort study Methods: A total of 182,419 subjects who received thyroidectomy for thyroid cancer during 2004-2012 were selected from the Korean National Health Insurance data, which covers approximately 97% of the entire Korean population...
October 1, 2018: European Journal of Endocrinology
Xinyu Yang, Xinye Li, Mengchen Yuan, Chao Tian, Yihan Yang, Xiaofeng Wang, Xiaoyu Zhang, Yang Sun, Tianmai He, Songjie Han, Guang Chen, Nian Liu, Yonghong Gao, Dan Hu, Yanwei Xing, Hongcai Shang
Some well-established immunotherapy, radiotherapy, postoperation, anticancer drugs such as anthracyclines, antimetabolites, human epidermal growth factor receptor 2 blockers, tyrosine kinase inhibitors, alkylating agents, checkpoint inhibitors, and angiogenesis inhibitors, are significantly linked to cardiotoxicity. Cardiotoxicity is a common complication of several cancer treatments. Some studies observed complications of cardiac arrhythmia associated with the treatment of cancer, including atrial fibrillation (AF), supraventricular arrhythmias, and cardiac repolarization abnormalities...
2018: Frontiers in Pharmacology
Vincenzo Livio Malavasi, Elisa Fantecchi, Laura Gianolio, Francesca Pesce, Giuseppe Longo, Marco Marietta, Stefano Cascinu, Gregory Y H Lip, Giuseppe Boriani
Prescription of anticoagulants (ACs) in patients with cancer and atrial fibrillation (AF) is challenging and the impact on survival is not defined. In this study data prospectively collected in Oncology Units were retrospectively evaluated. Among 4664 patients admitted for malignancy, 394 patients (8.4%) had documented AF (mean age of 74 ± 9) and AC was prescribed to 155 patients (40%). Neither the type of cancer, the stage of the disease (metastatic or not) nor the ongoing treatments were significantly associated with prescription of AC, which was independently associated with BMI (OR 1...
October 29, 2018: European Journal of Internal Medicine
Ming Yuan, Gary Tse, Zhiwei Zhang, Xu Han, William Kk Wu, Guangping Li, Yunlong Xia, Tong Liu
AIM: Cases of cardiotoxicity related to trastuzumab have been reported. This systematic review and meta-analysis evaluated the risk of atrial fibrillation (AF) in patients of breast cancer treated with trastuzumab. METHODS: PubMed and Embase were searched until September 2017 for articles that investigated AF incidence in patients receiving trastuzumab for breast cancer. RESULTS: A total of Fifteen studies involving 8124 patients treated with trastuzumab were included...
October 29, 2018: Cardiovascular Therapeutics
Nicklas Vinter, Amanda M S Christesen, Morten Fenger-Grøn, Anne Tjønneland, Lars Frost
Background Atrial fibrillation ( AF ) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of AF and a subsequent diagnosis of cancer may clarify whether a mutual cause exists, and may also guide clinicians about time windows of high risk of cancer occurrence. Methods and Results We conducted a population-based cohort study among 26 222 men and 28 879 women free of AF and cancer at baseline based on the Danish Diet, Cancer and Health study. The participants were followed for the development of AF (the Danish National Patient Registry) and subsequent cancer (the Danish Cancer Registry) until 2013...
September 4, 2018: Journal of the American Heart Association
Christina L Fanola, Christian T Ruff, Sabina A Murphy, James Jin, Anil Duggal, Noe A Babilonia, Piyamitr Sritara, Michele F Mercuri, Pieter W Kamphuisen, Elliott M Antman, Eugene Braunwald, Robert P Giugliano
Background Anticoagulation in patients with malignancy and atrial fibrillation is challenging because of enhanced risks for thrombosis and bleeding and the frequent need for invasive procedures. Data on direct oral antagonists in such patients are sparse. Methods and Results The ENGAGE AF - TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction Study 48) trial randomized 21 105 patients with atrial fibrillation to edoxaban or warfarin...
August 21, 2018: Journal of the American Heart Association
Daisuke Kimura, Ikuo Fukuda, Takao Tsushima, Takehiro Sakai, Satoko Umetsu, Yukari Ogasawara, Norihito Shimamura, Hiroki Ohkuma
OBJECTIVE: We analyzed acute ischemic stroke by thromboembolism in the early period after lung cancer surgery. METHODS: A retrospective review of the clinical records of patients who underwent lung resection for primary lung cancer was performed. Patients who underwent lobectomy, bilobectomy, and pneumonectomy were included. The clinical characteristics of the patients, the incidence of atrial fibrillation (Af) after surgery, and the incidence of acute ischemic stroke were analyzed...
October 26, 2018: General Thoracic and Cardiovascular Surgery
Florence Y Lai, Mintu Nath, Stephen E Hamby, John R Thompson, Christopher P Nelson, Nilesh J Samani
BACKGROUND: Adult height is associated with risk of several diseases, but the breadth of such associations and whether these associations are primary or due to confounding are unclear. We examined the association of adult height with 50 diseases spanning multiple body systems using both epidemiological and genetic approaches, the latter to identify un-confounded associations and possible underlying mechanisms. METHODS: We examined the associations for adult height (using logistic regression adjusted for potential confounders) and genetically determined height (using a two-sample Mendelian randomisation approach with height-associated genetic variants as instrumental variables) in 417,434 individuals of white ethnic background participating in the UK Biobank...
October 25, 2018: BMC Medicine
John Berntsson, J Gustav Smith, Linda S B Johnson, Martin Söderholm, Yan Borné, Olle Melander, Marju Orho-Melander, Jan Nilsson, Gunnar Engström
OBJECTIVE: Vascular endothelial growth factor D (VEGF-D) has important functions in lymphangiogenesis and angiogenesis. High plasma levels of VEGF-D have been associated with incidence of heart failure. The association of VEGF-D with atrial fibrillation (AF) and stroke is unclear and we hypothesised that VEGF-D could also be associated with incidence of AF and ischaemic stroke. METHODS: VEGF-D was measured in fasting blood samples of 4689 subjects (40% men) without a history of AF from the Malmö Diet and Cancer Study, a prospective, population-based study in Sweden...
October 16, 2018: Heart: Official Journal of the British Cardiac Society
Kehinde Obamiro, Kenneth Lee
OBJECTIVE: Information overload can negatively impact positive health behaviors such as cancer screening. The 8-item Cancer Information Overload (CIO) scale appears to be the only validated measure of health-related information overload. The present study assesses the validity of the CIO scale when modified for use in patients with atrial fibrillation (AF) residing in Australia. METHODS: We conducted a secondary analysis of data from a study of adult Australian patients with AF (N = 386) in which a modified version of the CIO scale was used...
October 3, 2018: Patient Education and Counseling
Majed A Refaai, Paul Riley, Tatsiana Mardovina, Phoenix D Bell
INTRODUCTION:  Fibrin monomer (FM) concentrations reflect pro-thrombin activity and have the potential to predict thrombotic events relatively earlier than other haemostatic markers. Most often, FM are compared with D-dimer (DD) as increased DD have been documented in disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT) and pulmonary embolism. Although DD have a high sensitivity and negative predictive value, their specificity is much lower depending on the assay chosen, clinical pre-test probability and patient condition...
November 2018: Thrombosis and Haemostasis
Miguel Cainzos-Achirica, Cristina Enjuanes, Philip Greenland, John W McEvoy, Mary Cushman, Zeina Dardari, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Michael D Miedema, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND AND AIMS: We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS: We included 6617 participants from the Multi-Ethnic Study of Atherosclerosis (5640 non-users, 977 users of statins at baseline). Main outcomes were hard ASCVD events and HF; secondary outcomes included all-cause death, atrial fibrillation, venous thromboembolism and cancer...
October 4, 2018: Atherosclerosis
Sean T Chen, Chiara Melloni
No abstract text is available yet for this article.
October 16, 2018: Journal of the American College of Cardiology
Wesley T O'Neal, J'Neka S Claxton, Pratik B Sandesara, Richard F MacLehose, Lin Y Chen, Lindsay G S Bengtson, Alanna M Chamberlain, Faye L Norby, Pamela L Lutsey, Alvaro Alonso
BACKGROUND: It is unknown whether early cardiology involvement shortly after atrial fibrillation (AF) diagnosis is associated with favorable outcomes in AF patients who have cancer. OBJECTIVES: The purpose of this study was to examine the relationship between early cardiology involvement after AF diagnosis in patients with history of cancer. METHODS: This study examined associations of early cardiology involvement with oral anticoagulation use, stroke, and bleeding among nonvalvular AF patients (n = 388,045; mean age 68 ± 15 years; 59% male) with a history of cancer (past or active) from the MarketScan database (2009 to 2014)...
October 16, 2018: Journal of the American College of Cardiology
Helena Kattelus, Y Antero Kesäniemi, Heikki Huikuri, Olavi Ukkola
INTRODUCTION: Relation between atrial fibrillation (AF) and cancer is known but not very well understood. The purpose of this prospective study was to find out whether subjects with cancer were at greater risk of AF than subjects without cancer. MATERIALS AND METHODS: The study was based on the OPERA (Oulu Project Elucidating Risk of Atherosclerosis) material and had 1045 subjects and the mean follow-up time of 16.3 years. During the follow-up AF and cancer diagnosis were made (atrial flutter included) if these events were listed in the National Death Registry and/or hospital discharge registry...
2018: PloS One
Nicola Maurea, Letizia Riva
Advances in cancer therapy have led to a significant improvement of survival in most types of malignancies over the past few decades. As a result, there is a growing population of cancer survivors, expected to reach 18 million people in 2030 in the US and a similar number in Europe. Interestingly, cancer survivor studies have shown that although about half of these patients eventually die of cancer, one third of them actually die of cardiovascular disease. Arrhythmias represent a significant part of cardiovascular complications and atrial fibrillation is the main arrhythmia occurring in cancer patients...
September 2018: Giornale Italiano di Cardiologia
Nicola Maurea, Letizia Riva
No abstract text is available yet for this article.
September 2018: Giornale Italiano di Cardiologia
D Vakhitov, N Oksala, E Saarinen, K Vakhitov, J Salenius, V Suominen
OBJECTIVES: To evaluate the long-term survival and treatment-related outcome in patients treated with intra-arterial thrombolysis for acute lower limb ischemia (ALLI). METHODS: The study was based on a prospective vascular database with retrospectively obtained supplementary information from the patients' files. Additionally, data on the patients' date and cause of death were obtained from Statistics Finland. A total of 155 patients with symptoms or signs of category I-IIa ALLI and angiographic evidence of native artery or bypass graft thromboembolic events were treated with intra-arterial catheter-directed thrombolysis (CDT)...
September 29, 2018: Annals of Vascular Surgery
Ana Pardo Sanz, Luis Miguel Rincón Díaz, Alejandra Sofía Tamayo, Gregorio de Lara Delgado, Helena Contreras, José Luis Zamorano Gómez
No abstract text is available yet for this article.
September 28, 2018: Revista Española de Cardiología
Xiaofeng He, Minke Shi, Bin Cao
OBJECTIVE: To explore the impact of the gastric tube diameter on quality of life of esophagus cancer patients after Ivor-Lewis esophagectomy. METHODS: Clinical and follow-up data of 188 esophageal cancer patients who underwent Ivor-Lewis esophagectomy at Department of Cardio-Thoracic Surgery, Drum Tower Clinical Medicine College, Nanjing Medical University from January 2015 to June 2016 were retrospectively analyzed. Inclusion criteria included age <75 years old, good foundation health situation, no distant metastasis, complete follow-up data for one-year after surgery, and middle-lower esophageal squamous cell carcinoma (ESCC)...
September 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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