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Atrial fibrilation and cancer

Rashmi R Shah
Histone deacetylases (HDACs) are expressed at increased levels in cells of various malignancies, and the use of HDAC inhibitors has improved outcomes in patients with haematological malignancies (T-cell lymphomas and multiple myeloma). However, they are not as effective in solid tumours. Five agents are currently approved under various jurisdictions, namely belinostat, chidamide, panobinostat, romidepsin and vorinostat. These agents are associated with a range of class-related and agent-specific serious and/or severe adverse effects, notably myelosuppression, diarrhoea and various cardiac effects...
January 16, 2019: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Fumi Kiyuna, Noriko Sato, Ryu Matsuo, Masahiro Kamouchi, Jun Hata, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Takanari Kitazono
Importance: It is unknown whether poststroke outcome varies between different potential causes in patients with cryptogenic stroke. Objective: To investigate whether functional outcome differs according to potential embolic sources after cryptogenic stroke. Design, Setting, and Participants: This multicenter, hospital-based, prospective stroke registry cohort study investigated potential embolic sources on admission and assessed 3-month outcome in patients with ischemic stroke hospitalized at 7 stroke centers in the Fukuoka Stroke Registry...
September 7, 2018: JAMA network open
Salomeh Keyhani, Erin Madden, Eric M Cheng, Dawn M Bravata, Ethan Halm, Peter C Austin, Mehrnaz Ghasemiesfe, Ann S Abraham, Alysandra J Zhang, Jason M Johanning
Importance: Randomized clinical trials have demonstrated that patients with asymptomatic carotid stenosis are eligible for carotid endarterectomy (CEA) if the 30-day surgical complication rate is less than 3% and the patient's life expectancy is at least 5 years. Objective: To develop a risk prediction tool to improve patient selection for CEA among patients with asymptomatic carotid stenosis. Design, Setting, and Participants: In this cohort study, veterans 65 years and older who received both carotid imaging and CEA in the Veterans Administration between January 1, 2005, and December 31, 2009 (n = 2325) were followed up for 5 years...
January 9, 2019: JAMA Surgery
F Plank, B Stowasser, D Till, W Schgör, W Dichtl, F Hintringer, G Weiss, M Stühlinger
BACKGROUND: Exposure to high doses of radiation during cardiac interventional procedures is associated with increased rates of cataract and cancer in patients and staff members. Thus, reduction of radiation is recommended by international medical societies. The aim of this study was to evaluate, if the lowest reasonable fluoroscopic acquisition setting for electrophysiological procedures using a novel X-ray detector operated at a minimum detector entrance dose per fluoroscopy pulse is feasible and safe...
January 2019: European Journal of Radiology
Mar Martín-Pérez, David Gaist, Francisco J de Abajo, Luis A García Rodríguez
BACKGROUND:  Many patients on warfarin therapy often present with supratherapeutic international normalized ratio (INR) levels, resulting from the influence of several patient-specific factors, which have been associated with adverse outcomes. OBJECTIVE:  This article aims to identify risk factors for over-anticoagulation (INR levels ≥4) in a cohort of patients taking warfarin. METHODS:  A cohort of warfarin users aged 18 to 85 years from January 2005 to April 2013 was identified in The Health Improvement Network U...
January 2019: Thrombosis and Haemostasis
Egle Karinauske, Silvijus Abramavicius, Greta Musteikiene, Edgaras Stankevicius, Jurgita Zaveckiene, Vidas Pilvinis, Edmundas Kadusevicius
BACKGROUND: Amiodarone is an antiarrhythmic drug which is used to treat and prevent several dysrhythmias. This includes ventricular tachycardia and fibrillation, wide complex tachycardia, as well as atrial fibrillation (AF) and paroxysmal supraventricular tachycardia. Amiodarone may prove to be the agent of choice where the patient is hemodynamically unstable and unsuitable for direct current (DC) cardioversion. Although, it is not recommended for long-term use. The physician might encounter issues when differentiating amiodarone-induced lung toxicity with suspicion of interstitial lung disease, cancer or vasculitis...
December 29, 2018: BMC Pharmacology & Toxicology
Glenda Euceda, Wing-Tai Kong, Amber Kapoor, John E Hokanson, Patricia Dilauro, Rahila Ogunnaike, John Chronakos
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is one of the leading causes of hospitalization in the United States. Prior investigations suggest clinical and physiological parameters are important determinants for AECOPD readmissions. Strategies aimed at addressing these factors have not resulted in a major reduction of readmissions. We compared patients readmitted after an index AECOPD admission with non-readmitted patients. Patients' age, gender, body mass index, comorbidities (obstructive sleep apnea, chronic hypercapnia, congestive heart failure, lung cancer, pulmonary arterial hypertension, pneumonia, interstitial lung disease, atrial fibrillation, musculoskeletal disorders, cognitive disorders, and anxiety disorders), substance abuse and smoking status were assessed...
May 17, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
Hesham R El-Seedi, Shaden A M Khalifa, Eman A Taher, Mohamed A Farag, Aamer Saeed, Mohamed Gamal, Mohamed-Elamir F Hegazy, Diaa Youssef, Syed G Musharraf, Muaaz M Alajlani, Jianbo Xiao, Thomas Efferth
Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na+ /K+ -ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation...
December 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Sarju Ganatra, Ajay Sharma, Sachin Shah, Ghulam M Chaudhry, David T Martin, Tomas G Neilan, Syed Saad Mahmood, Ana Barac, John D Groarke, Salim S Hayek, Saurbha Dani, David Venesy, Richard Patten, Anju Nohria
Ibrutinib, a novel and potent Bruton tyrosine kinase inhibitor, is an effective and well-tolerated treatment for a variety of B-cell lymphomas. However, its use is associated with an increased incidence of atrial fibrillation (AF), ranging from 4% to 16%. We reviewed the original clinical trials that led to the approval of ibrutinib, as well as several other prospective and retrospective studies, to better appreciate the incidence of ibrutinib-associated AF. Based on 16 studies included in our analysis, the incidence of ibrutinib-associated AF was 5...
December 2018: JACC. Clinical Electrophysiology
Hsien-Feng Lin, Kuan-Fu Liao, Ching-Mei Chang, Cheng-Li Lin, Shih-Wei Lai, Chung-Y Hsu
The association between tamoxifen use and risk of deep vein thrombosis or pulmonary embolism in women with breast cancer has been reported in the Western population. The study aimed to evaluate the association between tamoxifen use and deep vein thrombosis or pulmonary embolism in older women with breast cancer in Taiwan.We conducted a retrospective case-control study using the database of the Taiwan National Health Insurance Program. A total of 281 women subjects with breast cancer aged ≥65 years with newly diagnosed deep vein thrombosis/or pulmonary embolism from 2000 to 2011 were identified as the cases...
December 2018: Medicine (Baltimore)
Cecilia Monge, Hoyoung Maeng, Alessandra Brofferio, Andrea B Apolo, Bharath Sathya, Andrew E Arai, James L Gulley, Marijo Bilusic
BACKGROUND: Immune checkpoint inhibitors have revolutionized treatment and improved survival in many cancers. However, since immune-related adverse events (irAEs) are potentially fatal, early recognition and prompt treatment are warranted. One of the rarest but most dramatic irAE is myocarditis, which has significant morbidity and mortality if not recognized and treated early. OBJECTIVE: To report the first case of myocarditis in a patient with metastatic castration-resistant prostate cancer (mCRPC) treated with a combination of nivolumab, an anti-programmed cell death protein 1 antibody, and PROSTVAC, a vector-based therapeutic prostate cancer vaccine...
December 18, 2018: Journal for Immunotherapy of Cancer
Matthew S Davids, Haesook T Kim, Alyssa Nicotra, Alexandra Savell, Karen Francoeur, Jeffrey M Hellman, Josie Bazemore, Hari P Miskin, Peter Sportelli, Laura Stampleman, Rodrigo Maegawa, Jens Rueter, Adam M Boruchov, Jon E Arnason, Caron A Jacobson, Eric D Jacobsen, David C Fisher, Jennifer R Brown
BACKGROUND: Patients with relapsed or refractory high-risk chronic lymphocytic leukaemia or mantle cell lymphoma often do not derive durable benefit from ibrutinib monotherapy. We hypothesised that dual B-cell receptor pathway blockade would be tolerable and efficacious. We investigated a next-generation phosphoinositide-3-kinase-δ inhibitor (PI3K-δi), umbralisib, plus a Bruton tyrosine kinase inhibitor (BTKi), ibrutinib, in relapsed or refractory chronic lymphocytic leukaemia and mantle cell lymphoma...
December 14, 2018: Lancet Haematology
Yu-Feng Hu, Shih-Lin Chang, Chang-Ming Chern, Cheng-Hsueh Wu, Yenn-Jiang Lin, Li-Wei Lo, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ting-Yung Chang, Ting-Chun Huang, Cheng-I Wu, Chih-Min Liu, Simon Salim, Jennifer Jeanne Vicera, Le Phat Tai, Shih-Ann Chen
Whether bleeding should be considered a sufficient sign to justify thorough cancer surveillance in atrial fibrillation (AF) patients receiving nonvitamin K antagonist oral anticoagulants (NOACs) remains unclear. We investigated the relationships between bleeding events and new-onset cancers in AF patients receiving NOACs in a prospective cohort (n = 395, mean follow-up duration of 2.8 years). There were 18 patients who were diagnosed with new-onset cancers 584 ± 372 days after the initiation of NOACs. The patients with new-onset cancers had higher HAS-BLED scores (no, preexisting and new-onset cancer: 1...
December 3, 2018: American Journal of Cardiology
Yankui Ding, Qiming Wang, Yang Yang, Liansheng Wang
OBJECTIVE: To evaluate the diagnostic value of copeptin and cancer antigen 125 (Ca-125) in acute heart failure (AHF) patients with atrial fibrillation, and to explore the relationship between copeptin, Ca-125 and short-term cardiovascular events. METHODS: A total of 376 patients with acute left heart failure or permanent atrial fibrillation admitted to the Department of Cardiology of First Affiliated Hospital of Nanjing Medical University from January 2016 to January 2018 were enrolled as the study group...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Denise Buchner, Lena Hieggelke, Heike Löser, Christiane Josephine Bruns, Alexander Quaas, Markus Philipp Hussein Ghadimi
BACKGROUND: Collision tumors are rare cases with two different tumor entities growing synchronously. While adenocarcinoma of the pancreas is the most common pancreatic tumor with an incidence of 10 per 100.000, retroperitoneal liposarcoma remains very rare. This is the first report of a collision tumor between these two tumor entities. CASE PRESENTATION: Demographic details: The tumor was diagnosed in a 64 male Caucasian patient. Besides atrial fibrillation, arterial hypertension and a hypothyroidism there is no relevant medical history especially no history of cancer...
December 12, 2018: BMC Cancer
Pia Thisted Dinesen, Thomas Andersen Rix, Albert Marni Joensen, Christina Cathrine Dahm, Søren Lundbye-Christensen, Erik Berg Schmidt, Kim Overvad
Fatty acids in adipose tissue share dietary sources and metabolic pathways and therefore occur in patterns. The aim of the present study was to investigate the association between adipose tissue fatty acid patterns identified by the data-driven dimension-reducing method treelet transform and the risk of atrial fibrillation. A total of 57,053 Danish men and women aged 50-64 years participating in the Diet, Cancer and Health cohort had an adipose tissue biopsy taken at baseline. During a median follow-up of 14...
2018: PloS One
Cédric Pinier, Philippe Gatault, Maud François, Christelle Barbet, Hélène Longuet, Nolwenn Rabot, Johann Noble, Elodie Bailly, Matthias Buchler, Bénédicte Sautenet, Jean-Michel Halimi
Background: Renal patients with diabetes mellitus are at very high risk of death before and after chronic dialysis initiation. Risk factors for death in this population are not clearly identified. Methods: We performed a retrospective survival analysis in 861 patients with diabetes mellitus consecutively followed up in the 2000-13 period in a nephrology setting. Results: The mean age was 70  ±  10 years [men 65.2%; diabetes duration 13...
December 2018: Clinical Kidney Journal
S Zewari, L Hadi, F van den Elshout, R Dekhuijzen, Y Heijdra, P Vos
COPD and obesity often coexist and there is a complex interaction between them. Our aim was to evaluate the prevalence of obesity in a secondary care COPD population. Furthermore, the presence of comorbidities in obese (COPDOB ) and non-obese COPD (COPDNO ) individuals was studied. In 1654 COPD patients (aged ≥18 years) who visited a pulmonologist between January 2015 and December 2015, patient characteristics, pulmonary function tests and comorbidities were obtained from the medical records. Subjects were categorized according their BMI as underweight (<18...
December 4, 2018: COPD
Lucio Cagini, Gabriela Cardaioli, Marco Andolfi, Ketty Savino, Paolo Eusebi, Ilenia Corbelli, Simone Simoni, Jacopo Vannucci, Elisa Sacchini, Francesco Ripandelli, Alberto Matricardi, Francesco Puma
BACKGROUND: Patent foramen ovale (PFO) is present in up to 25% of the general population and is considered an irrelevant condition in healthy subjects. Here we sought to determine an association between the presence of an asymptomatic PFO at baseline and postoperative short-term adverse events in patients undergoing major pulmonary resection for lung cancer. As well, we evaluated for the rate of PFO after pulmonary resections. METHODS: This prospective, observational study assessed patients by transcranial doppler (TCD) with contrast at baseline and discharge...
November 30, 2018: Annals of Thoracic Surgery
Tyler J Mouw, Jennifer Lu, Meghan Woody-Fowler, John Ashcraft, Joseph Valentino, Peter DiPasco, Joshua Mammen, Mazin Al-Kasspooles
Background: Liver resection in conjunction with partial colectomy for colon cancer is considered acceptable treatment for isolated metastasis to the liver. This method is unstudied in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for carcinomatosis due to colon cancer and high grade appendiceal cancer. Methods: A retrospective chart review included patients from 2005 to 2016 undergoing CRS/HIPEC. Cancers other than colorectal adenocarcinoma and high grade appendiceal carcinoma were excluded...
October 2018: Journal of Gastrointestinal Oncology
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