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Random control trails

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https://www.readbyqxmd.com/read/27904985/effectiveness-of-an-intervention-to-enhance-occupational-physicians-guideline-adherence-on-sickness-absence-duration-in-workers-with-common-mental-disorders-a-cluster-randomized-controlled-trial
#1
Karlijn M van Beurden, Evelien P M Brouwers, Margot C W Joosen, Michiel R de Boer, Jaap van Weeghel, Berend Terluin, Jac J L van der Klink
Purpose Evidence-based guidelines in occupational health care improve the quality of care and may reduce sickness absence duration. Notwithstanding that, guideline adherence of occupational physicians (OPs) is limited. Based on the literature on guideline implementation, an intervention was developed that was shown to effectively improve self-reported adherence in OPs. The aim of present study was to evaluate whether this intervention leads to earlier return to work (RTW) in workers with common mental disorders (CMD)...
November 30, 2016: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/27904618/assessment-of-different-anesthesia-depth-under-total-intravenous-anesthesia-on-postoperative-cognitive-function-in-laparoscopic-patients
#2
Delin Zhang, Aiqing Nie
BACKGROUND: This study aimed to compare the effects of different depths of sedation during total intravenous anesthesia (TIVA) with remifentanil and propofol given by target-controlled infusion (TCI) on postoperative cognitive function in young and middle-aged patients undergoing gynecological laparoscopic surgery. MATERIALS AND METHODS: A total of 150 American Society of Anesthesiologists physical Status I/II patients scheduled for gynecological laparoscopic operation were randomly divided into three groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27902588/short-term-hypertension-management-in-community-is-associated-with-long-term-risk-of-stroke-and-total-death-in-china-a-community-controlled-trial
#3
Zengwu Wang, Guang Hao, Xin Wang, Wen Wang, Weiwei Chen, Manlu Zhu
BACKGROUND: It is not fully clear whether the effect of short-term management in community can reduce the long-term risk of stroke OBJECTIVES:: To evaluate whether short-term hypertension management is associated with long-term incidence of stroke and total death in community health centers in China. DESIGN: Community controlled trail. PARTICIPANTS: Six community health centers (4 active, 2 control) in China, patients with hypertension. CONTROL ARM: Patients were treated with normally therapy method...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27874176/effects-of-tai-chi-on-cognition-and-fall-risk-in-older-adults-with-mild-cognitive-impairment-a-randomized-controlled-trial
#4
Somporn Sungkarat, Sirinun Boripuntakul, Nipon Chattipakorn, Kanokwan Watcharasaksilp, Stephen R Lord
OBJECTIVES: To examine whether combined center- and home-based Tai Chi training can improve cognitive ability and reduce physiological fall risk in older adults with amnestic mild cognitive impairment (a-MCI). DESIGN: Randomized controlled trial. SETTING: Chiang Mai, Thailand. PARTICIPANTS: Adults aged 60 and older who met Petersen's criteria for multiple-domain a-MCI (N = 66). INTERVENTION: Three weeks center-based and 12 weeks home-based Tai Chi (50 minutes per session, 3 times per week)...
November 22, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27872642/rationale-and-design-of-rnafh-study-effect-of-rosuvastatin-10%C3%A2-mg-d-on-nonalcoholic-fatty-liver-in-metabolic-syndrome-patients-without-overt-diabetes-evaluated-by-1-h-magnetic-resonance-spectroscopy
#5
Fan Ping, Xuan Wang, Jing Yang, Mei-Cen Zhou, Wei Li, Ling-Ling Xu, Yu-Xiu Li
Objective. The RNAFH study (effect of rosuvastatin on nonalcoholic fatty liver disease in metabolic syndrome patients without overt diabetes evaluated by (1)H-MRS) is a prospective randomized, single-center, open-label trail designed to assess the effect of rosuvastatin on the intrahepatocellular lipid (IHCL) level of nonalcoholic fatty liver disease (NAFLD). Methods. 40 NAFLD patients meeting inclusion and exclusion criteria with metabolic syndrome (MS) but without overt diabetes mellitus will be included...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27871806/does-vertebral-augmentation-lead-to-an-increasing-incidence-of-adjacent-vertebral-failure-a-systematic-review-and-meta-analysis
#6
REVIEW
Baoyou Fan, Zhijian Wei, Xianhu Zhou, Wei Lin, Yiming Ren, Ang Li, Guidong Shi, Yan Hao, Shen Liu, Hengxing Zhou, Shiqing Feng
BACKGROUND: The aim of the present study was to evaluate whether vertebral augmentation technology increases the occurrence of adjacent vertebral fractures in patients with osteoporotic vertebral compression fractures (OVCFs). MATERIALS AND METHODS: Databases, including MEDLINE, EMBASE and Cochrane library, were retrieved via PRISMA covering 1987 to 2015. The number of patients who suffered from adjacent secondary vertebral fractures was calculated. A meta-analysis, using indexes of odds ratios (OR) and 95% confidence intervals (95% CI), was conducted with STATA software...
November 15, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27869715/randomized-prospective-double-blind-studies-to-evaluate-the-cognitive-effects-of-inositol-stabilized-arginine-silicate-in-healthy-physically-active-adults
#7
Douglas Kalman, Philip D Harvey, Sara Perez Ojalvo, James Komorowski
Inositol-stabilized arginine silicate (ASI; Nitrosigine(®)) has been validated to increase levels of arginine, silicon and nitric oxide production. To evaluate potential enhancement of mental focus and clarity, ASI (1500 mg/day) was tested in two double-blind placebo-controlled crossover (DBPC-X) studies using the Trail Making Test (TMT, Parts A and B). In the two studies, healthy males took ASI for 14 and 3 days, respectively. In the first study, after 14 days of dosing, TMT B time decreased significantly from baseline (28% improvement, p = 0...
November 18, 2016: Nutrients
https://www.readbyqxmd.com/read/27858069/-clinical-study-on-the-effect-of-anti-gingivitis-igy-toothpaste-in-control-of-gingivitis-and-dental-plaque
#8
Wei Zhang, Xi-Ping Feng, Dan-Ying Tao, Jian-Fen Chen
PURPOSE: To observe the effect of anti-gingivitis IgY toothpaste in control of gingivitis and plaque. METHODS: The study was a double-blind, randomized, parallel-controlled clinical trail with a total of 100 subjects who were divided into two groups, experimental group and control group. The subjects in experimental group used anti-gingivitis IgY toothpaste to brush twice daily for 3 minutes, and the subjects in control group used none anti-gingivitis IgY toothpaste...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27837000/perspectives-answering-questions-about-quality-improvement-suggestions-for-investigators
#9
REVIEW
John Øvretveit
'Does it work?' is not the only question that practical improvers have of those investigating of quality improvements. They also want to know, 'Will it work here? What conditions do we need to implement and sustain it? Can we adapt it? How much will it cost and save? Is there enough evidence to spread it?'This perspectives article describes methods that investigators can use to answer these questions about improvement changes and improvement methods. It suggests that one reason why research is underused by improvers is because there is little research that answers these questions that would enable improvers to decide whether or how to implement an improvement in their local setting...
November 10, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27820726/%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-supplementation-effects-on-body-mass-and-performance-in-elite-male-rugby-union-players
#10
Nicholas D McIntosh, Thomas D Love, Jillian Haszard, Hamish Osborne, Katherine E Black
Pre-season is characterized by high training volumes with short recovery periods β-hydroxy β-methylbutyrate (HMB) has been postulated to assist with recovery. HMB has been shown to improve strength and body composition amongst untrained groups the benefits of HMB amongst trained populations are unclear due to the methodologies employed. This randomized control trail determined the effects of 11 weeks HMB supplementation on body mass and performance measures in 27 elite rugby players. HMB group (n=13) mean±SD age 20...
October 27, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27809558/hatha-yoga-practice-improves-attention-and-processing-speed-in-older-adults-results-from-an-8-week-randomized-control-trial
#11
Neha P Gothe, Arthur F Kramer, Edward McAuley
BACKGROUND: Age-related cognitive decline is well documented across various aspects of cognitive function, including attention and processing speed, and lifestyle behaviors such as physical activity play an important role in preventing cognitive decline and maintaining or even improving cognitive function. PURPOSE: The purpose of this study was to evaluate the effects of an 8-week Hatha yoga intervention on attention and processing speed among older adults. METHODS: Participants (n = 118; mean age, 62 ± 5...
November 3, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27806718/benefits-of-virtual-reality-based-cognitive-rehabilitation-through-simulated-activities-of-daily-living-a-randomized-controlled-trial-with-stroke-patients
#12
Ana Lúcia Faria, Andreia Andrade, Luísa Soares, Sergi Bermúdez I Badia
BACKGROUND: Stroke is one of the most common causes of acquired disability, leaving numerous adults with cognitive and motor impairments, and affecting patients' capability to live independently. There is substancial evidence on post-stroke cognitive rehabilitation benefits, but its implementation is generally limited by the use of paper-and-pencil methods, insufficient personalization, and suboptimal intensity. Virtual reality tools have shown potential for improving cognitive rehabilitation by supporting carefully personalized, ecologically valid tasks through accessible technologies...
November 2, 2016: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/27806559/investigation-the-effects-of-metformin-versus-insulin-on-neonatal-and-maternal-outcomes-in-women-with-gestational-diabetes-mellitus-a-randomized-clinical-trail
#13
Mahin Najafian, Mojgan Barati, Sara Masihi, Ailin Fardipor
The aim of this study was to evaluate the effectiveness of metformin versus insulin in the glycemic control and to investigate the maternal and neonatal outcomes in in women with gestational diabetes mellitus. Pregnant women with gestational diabetes were randomized to either receive metformin (n=70) or insulin (n=70). Inclusion criteria were singleton pregnancy, following healthy diet and performing exercise for at least one week without satisfactory blood glucose level, no risk factor contributing to lactic acidosis, and no anatomic and/or chromosome anomalies...
September 28, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27780334/efficacy-of-vortioxetine-on-cognitive-functioning-in-working-patients-with-major-depressive-disorder
#14
Roger S McIntyre, Ioana Florea, Brigitte Tonnoir, Henrik Loft, Raymond W Lam, Michael Cronquist Christensen
OBJECTIVE: This post hoc analysis investigates the effect of vortioxetine on cognitive functioning and depressive symptoms in working adults with major depressive disorder (MDD). METHODS: Population data from FOCUS, a double-blind, randomized, placebo-controlled study investigating the efficacy of vortioxetine versus placebo on cognitive functioning and depression in patients with MDD, were used to analyze mean change from baseline scores for the Digit Symbol Substitution Test (DSST), Trail Making Test A/B (TMT-A/B), Stroop, and Perceived Deficits Questionnaire (PDQ)...
October 25, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27759644/the-research-on-long-term-clinical-effects-and-patients-satisfaction-of-gabapentin-combined-with-oxycontin-in-treatment-of-severe-cancer-pain
#15
Dong-Liang Chen, Yu-Hong Li, Zhi-Juan Wang, Ye-Ke Zhu
Gabapentin has been used as an adjuvant for treatment of cancer pain. Previous studies showed that opioids combined with gabapentin for management of cancer pain reduced the dosage of opioids.The objective of this study was to explore the clinical effect and patients' satisfaction of oxycontin combined with gabapentin in treatment of severe cancer pain. After titration of morphine, 60 severe cancer patients with visual analog score (VAS) more than 7 were randomly divided into trial group (n = 30) and control group (n = 30)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27751958/neural-control-of-arm-movements-reveals-a-tendency-to-use-gravity-to-simplify-joint-coordination-rather-than-to-decrease-muscle-effort
#16
Wanyue Wang, Natalia Dounskaia
How gravity influences neural control of arm movements remains under debate. We tested three alternative interpretations suggested by previous research: (1) that muscular control includes two components, tonic which compensates for gravity and phasic which produces the movement; (2) that there is a tendency to exploit gravity to reduce muscle effort; and (3) that there is a tendency to use a trailing pattern of joint control during which either the shoulder or elbow is rotated actively and the other joint rotates predominantly passively, and to exploit gravity for control of the passively rotated joint...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27717360/the-effect-of-changing-the-built-environment-on-physical-activity-a-quantitative-review-of-the-risk-of-bias-in-natural-experiments
#17
Jack S Benton, Jamie Anderson, Ruth F Hunter, David P French
BACKGROUND: Evidence regarding the association of the built environment with physical activity is influencing policy recommendations that advocate changing the built environment to increase population-level physical activity. However, to date there has been no rigorous appraisal of the quality of the evidence on the effects of changing the built environment. The aim of this review was to conduct a thorough quantitative appraisal of the risk of bias present in those natural experiments with the strongest experimental designs for assessing the causal effects of the built environment on physical activity...
October 7, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27709231/novel-therapy-of-hyperhomocysteinemia-in-mild-cognitive-impairment-alzheimer-s-disease-and-other-dementing-disorders
#18
J Hara, W R Shankle, L W Barrentine, M V Curole
OBJECTIVES: Studies have produced conflicting results assessing hyperhomocysteinemia (HYH) treatment with B vitamins in patients with normal cognition, Alzheimer's disease and related disorders (ADRD). This study examined the effect of HYH management with L-methylfolate (LMF), methylcobalamin (MeCbl; B12), and N-acetyl-cysteine (CFLN: Cerefolin®/Cerefolin-NAC®) on cognitive decline. DESIGN: Prospective, case-control study of subjects followed longitudinally. SETTING: Outpatient clinic for cognitive disorders...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27707440/vitamin-d-improves-selected-metabolic-parameters-but-not-neuropsychological-or-quality-of-life-indices-in-osas-a-pilot-study
#19
Conor P Kerley, Katrina Hutchinson, Jessica Bramham, Aisling McGowan, John Faul, Liam Cormican
STUDY OBJECTIVES: Our group and others have reported a high rate of vitamin D deficiency in obstructive sleep apnoea syndrome (OSAS), where vitamin D levels (25(OH)D) correlate negatively with OSAS severity and some of its associated metabolic alterations. Data regarding vitamin D supplementation in OSAS are lacking. We wanted to evaluate the effect of vitamin D3 supplementation on OSAS symptoms and metabolic parameters. METHODS: We conducted a pilot, double-blind, randomized, placebo-controlled trial of daily supplementation with 4,000 IU vitamin D3 (D3) or placebo (PL)...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27684791/comparison-of-vitrification-and-conventional-slow-freezing-for-cryopreservation-of-ovarian-tissue-with-respect-to-the-number-of-intact-primordial-follicles-a-meta-analysis
#20
Xin-Hui Zhou, Dan Zhang, Jin Shi, Yi-Jun Wu
BACKGROUND: Vitrification is the standard method for cryopreserving human oocytes and embryos, but its effects on ovarian tissue are uncertain. The purpose of this meta-analysis was to compare the proportion of intact primordial follicles in ovarian tissue cryopreserved with vitrification versus slow freezing. METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until November 11, 2014 using combinations of the search terms: ovarian tissue, cryopreservation, vitrification, follicle, follicles...
September 2016: Medicine (Baltimore)
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