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Random control trails

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https://www.readbyqxmd.com/read/29036816/sex-difference-in-aerobic-exercise-efficacy-to-improve-cognition-in-older-adults-with-vascular-cognitive-impairment-secondary-analysis-of-a-randomized-controlled-trial
#1
Cindy K Barha, Ging-Yuek R Hsiung, John R Best, Jennifer C Davis, Janice J Eng, Claudia Jacova, Philip E Lee, Michelle Munkacsy, Winnie Cheung, Teresa Liu-Ambrose
Aerobic training (AT) is a promising, non-pharmacological intervention to mitigate the deleterious effects of aging and disease on brain health. However, a large amount of variation exists in its efficacy. This is a secondary analysis of a randomized controlled trial of AT in 71 older adults with subcortical ischemic vascular cognitive impairment (NCT01027858). Specifically, we investigated: 1) whether sex moderates the relationship between AT and executive functions, and 2) the role of brain derived neurotrophic factor (BDNF) and gains in functional fitness capacity...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29027351/robotic-assisted-versus-open-radical-cystectomy-in-bladder-cancer-a-meta-analysis-of-four-randomized-controlled-trails
#2
Jin-Qiu Tang, Zhihong Zhao, Yiwen Liang, Guixiang Liao
BACKGROUND: Robot-assisted radical cystectomy (RARC) is increasing annually for treatment of bladder cancer. The objective of this meta-analysis was to compare the safety and efficacy of RARC and open radical cystectomy (ORC) for bladder cancer. METHODS: Our meta-analysis searches were conducted using PubMed, Web of Science, and Cochrane Library databases to identify randomized controlled trials (RCT) assessing the two techniques. RESULTS: Four RCT studies were identified, including 239 cases...
October 12, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29026977/mesh-versus-patch-repair-for-epigastric-and-umbilical-hernia-morpheus-trial-one-year-results-of-a-randomized-controlled-trial
#3
J E H Ponten, B J M Leenders, W K G Leclercq, T Lettinga, J Heemskerk, J L M Konsten, P S S Castelijns, S W Nienhuijs
DESIGN: This trial is a randomized controlled, patient-blinded, multicentre, superiority trial. METHODS: All patients ≥18 years with a single, symptomatic and primary umbilical or epigastric hernia (<2 fingers) qualified for participation in the study. Flat polypropylene mesh repair was compared to patch repair (PROCEED(®) Ventral Patch) (PVP). The objective of this trial was to identify a superior method for umbilical and epigastric hernia repair in terms of complication rates...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29019011/a-systematic-review-and-meta-analysis-of-mechanical-vs-biological-composite-aortic-root-replacement-early-and-1-year-results
#4
Mohamad Bashir, Amer Harky, Saied Froghi, Benjamin Adams, Megan Garner, Prity Gupta, Aung Oo, Rakesh Uppal
OBJECTIVE: Composite aortic root replacement is a standard procedure for various aortic root pathologies. This systematic review was set to identify the postoperative outcomes for composite mechanical root replacement (mCRR) compared to composite biological root replacement (bCRR). METHODS: We systematically reviewed four major databases for all papers assessing outcomes in composite root replacement. Articles selected were chosen by two reviewers. Amongst our inclusion and exclusion criteria, all pediatric populations were excluded as were studies with a cohort less than 50 patients...
October 10, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28975468/effect-of-restricted-protein-diet-supplemented-with-keto-analogues-in-end-stage-renal-disease-a-systematic-review-and-meta-analysis
#5
REVIEW
Zheng Jiang, Yi Tang, Lichuan Yang, Xuhua Mi, Wei Qin
AIM: To evaluate the efficacy and safety of the restricted protein diet supplemented with keto analogues when applied in end-stage renal disease (ESRD). METHODS: The Cochrane Library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to January 2017. Clinical trials were analyzed using RevMan 5.3 software. RESULTS: Five randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria...
October 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28972265/efficacy-of-a-web-based-intervention-for-concerned-spouses-of-service-members-and-veterans-with-alcohol-misuse
#6
Karen Chan Osilla, Thomas E Trail, Eric R Pedersen, Kristie L Gore, Anagha Tolpadi, Lindsey M Rodriguez
Concerned partners (CPs) of service members and veterans who misuse alcohol face help-seeking barriers and mental health problems. We used multiple regression to evaluate the efficacy of Partners Connect, a four-session web-based intervention (WBI) to address military CPs' mental health and communication. We randomized 312 CPs to the WBI or a control group. Five months later, WBI CPs reported significant reductions in their anxiety and increases in their social support compared to control CPs. Intervention dose was also associated with improved WBI CP outcomes...
October 3, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28953626/comparison-of-liposomal-bupivacaine-infiltration-versus-interscalene-nerve-block-for-pain-control-in-total-shoulder-arthroplasty-a-meta-analysis-of-randomized-control-trails
#7
REVIEW
Xiuling Cao, Fang Pan
BACKGROUND: This meta-analysis aimed to compare the efficiency and safety of liposomal bupivacaine infiltration and interscalene nerve block for pain control after total shoulder arthroplasty. METHODS: A systematic search was performed in Medline (1966 to May 2017), PubMed (1966 to May 2017), Embase (1980 to May 2017), ScienceDirect (1985 to May 2017) and the Cochrane Library. Only randomized controlled trials (RCTs) were included. Reported surgical outcomes, including visual analogue scale (VAS) scores, opioid consumption, length of stay, and postoperative adverse effects including the risk of nausea and vomiting...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28951111/registry-based-randomized-controlled-trials-merged-the-strength-of-randomized-controlled-trials-and-observational-studies-and-give-rise-to-more-pragmatic-trials
#8
Tim Mathes, Stefanie Buehn, Peggy Prengel, Dawid Pieper
OBJECTIVE: To analyze the features of registry-based randomized trials (rRCT). STUDY DESIGN: We systematically searched PubMed for rRCTs. Study selection was performed independently by two reviewers. We extracted all data in standardized tables and prepared descriptive summary statistics. RESULTS: The search resulted in 1202 hits. We included 71 rRCTs. Most rRCTs were from Denmark and Sweden. Chronic conditions were considered in 82.2%. A preventive intervention was examined in 45...
September 22, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28932989/predictors-of-response-to-glucagon-like-peptide-1-receptor-agonists-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#9
Matteo Monami, Ilaria Dicembrini, Besmir Nreu, Francesco Andreozzi, Giorgio Sesti, Edoardo Mannucci
AIMS: The aim of the present meta-analysis is the identification of the characteristics of patients, which predict the efficacy on HbA1c of glucagon-like peptide-1 receptor agonists (GLP-1 RA). METHODS: A Medline and Embase search for "exenatide" OR "liraglutide" OR "albiglutide" OR "dulaglutide" OR "lixisenatide" was performed, collecting randomized clinical trials (duration > 12 weeks) up to September 2016, comparing GLP-1 RA at the maximal approved dose with placebo or active drugs...
September 20, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28928788/da-cheng-qi-decoction-combined-with-conventional-treatment-for-treating-postsurgical-gastrointestinal-dysfunction
#10
REVIEW
Wei Jin, Qingjie Li, Xiaoqiong Luo, Juan Zhong, Yang Song, Yiwei Li
AIM: To assess the current clinical evidence of the effectiveness of Da-Cheng-Qi Decoction (DCQD) for the treatment of Postoperative gastrointestinal dysfunction (PGD). METHODS: Randomized controlled trails (RCTs) of Da-Cheng-Qi Decoction (DCQD) to PGD were searched from available major electronic databases to September 2016. The intervention must be a modified DCQD or DCQD integrated to Western Medicine (WM) compared with WM or placebo or blank. The main outcome index was clinical effectiveness and improvement of major symptoms...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28899341/development-of-a-home-based-training-program-for-post-ward-geriatric-rehabilitation-patients-with-cognitive-impairment-study-protocol-of-a-randomized-controlled-trail
#11
Martin Bongartz, Rainer Kiss, Phoebe Ullrich, Tobias Eckert, Jürgen Bauer, Klaus Hauer
BACKGROUND: Geriatric patients with cognitive impairment (CI) show an increased risk for a negative rehabilitation outcome and reduced functional recovery following inpatient rehabilitation. Despite this obvious demand, evidence-based training programs at the transition from rehabilitation to the home environments are lacking. The aim of this study is to evaluate the efficacy of a feasible and cost-effective home-based training program to improve motor performance and to promote physical activity, specifically-tailored for post-ward geriatric patients with CI...
September 12, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28870177/will-chinese-external-therapy-with-compound-tripterygium-wilfordii-hook-f-gel-safely-control-disease-activity-in-patients-with-rheumatoid-arthritis-design-of-a-double-blinded-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Quan Jiang, Xiao-Po Tang, Xian-Chun Chen, Hong Xiao, Ping Liu, Juan Jiao
BACKGROUND: Chinese external therapy (CET) is a topical application with mainly Chinese herb medicine therapy with thousands of years of historical implications and is a clinical routine that is commonly used for relieving joint-related symptoms in patients with arthritis in Chinese hospitals. However, there is a paucity of modern medical evidence to support its effectiveness and safety. Thus, we propose to implement a randomized, double-blinded, placebo-controlled clinical trial in patients with rheumatoid arthritis (RA) using, as the experimental intervention, topical application of a hospital-compounded gel preparation of Tripterygium wilfordii Hook F (TwHF)...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28870034/-the-efficacy-and-safety-of-insulin-degludec-versus-insulin-glargine-in-insulin-naive-subjects-with-type-2-diabetes-results-of-a-chinese-cohort-from-a-multinational-randomized-controlled-trial
#13
Y M Mu, L X Guo, L Li, Y M Li, X J Xu, Q M Li, M T Xu, L Y Zhu, G Y Yuan, Y Liu, C Xu, Z J Wang, F X Shen, Y Luo, J Y Liu, Q F Li, W H Wang, X Y Lai, H F Xu, C Y Pan
Objective: To compare the safety and efficacy of insulin degludec (IDeg) with those of insulin glargine (IGlar) in insulin-naive subjects with type 2 diabetes (T2DM). Methods: This was a 26-week, randomized, open-label, parallel-group, treat-to-target trial in 560 Chinese subjects with T2DM (men/women: 274/263, mean age 56 years, mean diabetes duration 7 years) inadequately controlled on oral antidiabetic drugs (OADs). Subjects were randomized 2∶1 to once-daily IDeg (373 subjects) or IGlar(187 subjects), both in combination with metformin...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28867858/evaluation-of-cyavanapr%C3%A4-%C3%A5-a-on-health-and-immunity-related-parameters-in-healthy-children-a-two-arm-randomized-open-labeled-prospective-multicenter-clinical-study
#14
Arun Gupta, Sunil Kumar, Sanjeeva Dole, Shailesh Deshpande, Vaishali Deshpande, Sudha Singh, V Sasibhushan
CONTEXT: Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing process. Benefits of CP have been studied widely in adult population. OBJECTIVES: Current study assessed beneficial effects of CP on health and immunity related parameters in healthy children. METHODS: This study was a 6 month long two armed, randomized, open labeled, prospective clinical study. School going healthy children between ages of 5-12 years were randomized to receive orally daily either CP (approx...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28859388/postoperative-pain-management-after-esophagectomy-a-systematic-review-and-meta-analysis
#15
E Visser, M Marsman, P S N van Rossum, E Cheong, K Al-Naimi, W A van Klei, J P Ruurda, R van Hillegersberg
Effective pain management after esophagectomy is essential for patient comfort, early recovery, low surgical morbidity, and short hospitalization. This systematic review and meta-analysis aims to determine the best pain management modality focusing on the balance between benefits and risks. Medline, Embase, and the Cochrane library were systematically searched to identify all studies investigating different pain management modalities after esophagectomy in relation to primary outcomes (postoperative pain scores at 24 and 48 hours, technical failure, and opioid consumption), and secondary outcomes (pulmonary complications, nausea and vomiting, hypotension, urinary retention, and length of hospital stay)...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28855183/effectiveness-of-online-tailored-advice-to-prevent-running-related-injuries-and-promote-preventive-behaviour-in-dutch-trail-runners-a-pragmatic-randomised-controlled-trial
#16
Luiz Carlos Hespanhol, Willem van Mechelen, Evert Verhagen
BACKGROUND: Trail running is popular worldwide, but there is no preventive intervention for running-related injury (RRI). AIM: To evaluate the effectiveness of adding online tailored advice (TrailS6 ) to general advice on (1) the prevention of RRIs and (2) the determinants and actual preventive behaviour in Dutch trail runners. METHODS: Two-arm randomised controlled trial over 6 months. 232 trail runners were randomly assigned to an intervention or control group...
August 30, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28837037/fresh-embryos-versus-freeze-all-embryos-transfer-strategies-nuances-of-a-meta-analysis
#17
REVIEW
Felipe C Dieamant, Claudia G Petersen, Ana L Mauri, V Comar, Mariana Mattila, Laura D Vagnini, Adriana Renzi, Bruna Petersen, Andreia Nicoletti, João Batista A Oliveira, Ricardo Lr Baruffi, Jose G Franco
OBJECTIVE: The present meta-analysis aimed to evaluate whether the freeze-all strategy (Freeze/All-ET) could bring about improvements in the clinical assisted reproductive technique (ART) outcomes when compared with the fresh embryo transfer strategy (Fresh-ET) in patients undergoing an ART cycle in accordance with the mean number of oocytes collected. METHODS: A systematic review based on electronic searches in databases (PubMed, EMBASE, Web of Science, SCOPUS, and Cochrane Central Register of Controlled Trials) was carried out to identify randomized controlled trails (RCTs) comparing ART outcomes between fresh-embryo transfers versus elective frozen-embryo transfers up to February of 2017...
September 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28831756/the-efficacy-of-transcranial-magnetic-stimulation-on-migraine-a-meta-analysis-of-randomized-controlled-trails
#18
REVIEW
Lihuan Lan, Xiaoni Zhang, Xiangpen Li, Xiaoming Rong, Ying Peng
OBJECTIVES: As a non-invasive therapy, whether transcranial magnetic stimulation (TMS) is effective on migraine. This article was aimed to assess the efficacy of TMS on migraine based on randomized controlled trails (RCTs). METHODS: We searched PubMed, Embase and Cochrane Library electronic databases for published studies which compared TMS group with sham group, conducted a meta-analysis of all RCTs. RESULTS: Five studies, consisting of 313 migraine patients, were identified...
August 22, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28827056/effect-of-zoledronic-acid-on-reducing-femoral-bone-mineral-density-loss-following-total-hip-arthroplasty-a-meta-analysis-from-randomized-controlled-trails
#19
REVIEW
Jian Gao, Chong Gao, Hui Li, Guo-Sheng Wang, Chang Xu, Jian Ran
OBJECTIVE: This meta-analysis aimed to assess the efficiency of intravenous administration of zoledronic acid on reducing femoral periprosthetic bone mineral density loss in patients undergoing primary total hip arthroplasty (THA). METHODS: A systematic search was performed in Medline (1966-2017.07.31), PubMed (1966-2017.07.31), Embase (1980-2017.07.31), ScienceDirect (1985-2017.07.31) and the Cochrane Library (1966-2017.07.31). Fixed/random effect model was used according to the heterogeneity tested by I(2) statistic...
August 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28826282/clinical-and-economic-outcomes-of-telemedicine-programs-in-the-intensive-care-unit-a-systematic-review-and-meta-analysis
#20
Jing Chen, Dalong Sun, Weiming Yang, Mingli Liu, Shufan Zhang, Jinhua Peng, Chuancheng Ren
OBJECTIVE: To evaluate the impact of telemedicine programs in intensive care unit (Tele-ICU) on ICU or hospital mortality or ICU or hospital length of stay and to summarize available data on implementation cost of Tele-ICU. METHODS: Controlled trails or observational studies assessing outcomes of interest were identified by searching 7 electronic databases from inception to July 2016 and related journals and conference literatures between 2000 and 2016. Two reviewers independently screened searched records, extracted data, and assessed the quality of included studies...
January 1, 2017: Journal of Intensive Care Medicine
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