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Random control trails

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https://www.readbyqxmd.com/read/29934249/treating-auditory-hallucinations-with-transcranial-direct-current-stimulation-in-a-double-blind-randomized-trial
#1
Sanne Koops, Jan Dirk Blom, Ouarda Bouachmir, Margot I Slot, Bas Neggers, Iris E Sommer
OBJECTIVE: Transcranial direct current stimulation (tDCS) could be a treatment option for medication-resistant auditory hallucinations (AH), but so far results have been inconclusive, and large sample trials have been missing. This study used tDCS as a treatment method for these hallucinations in a double-blind, placebo-controlled study with a relatively large sample size. METHODS: Fifty-four patients of several diagnostic categories with medication-resistant AH were randomized and treated during 10 sessions of 20 min each, with either 2 mA tDCS or placebo, administered on five consecutive days (i...
June 19, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29911519/the-effects-of-the-interventions-on-the-dnr-designation-among-cancer-patients-a-systematic-review
#2
Li-Ting Chen, Fei-Hsiu Hsiao
OBJECTIVE: The aims of this systematic review were to examine the effects of the overall and the different types of the interventions on the do-not-resuscitate (DNR) designation and the time between DNR and death among cancer patients. METHOD: Data were searched from the databases of PubMed, CINAHL, EMbase, Medline, and Cochrane Library through 2 November 2017. Studies were eligible for inclusion if they were (1) randomized control trails, quasi-experimental study, and retrospective observational studies and (2) used outcome indicators of DNR designation rates...
June 18, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29904617/comparing-the-harmonic-scalpel-with-electrocautery-in-reducing-postoperative-flap-necrosis-and-seroma-formation-after-modified-radical-mastectomy-in-carcinoma-breast-patients-a-double-blind-prospective-randomized-control-trail
#3
Arumugom Archana, Sathasivam Sureshkumar, Chellappa Vijayakumar, Chinnakali Palanivel
Introduction Only a few studies compare the efficacy of the harmonic scalpel and electrocautery in performing mastectomies, and these have mainly compared their intraoperative parameters. But the main concern with electrocautery is the incidence of flap necrosis and seroma formation. Therefore, this study was done to determine if the harmonic scalpel has any advantages over electrocautery in reducing postoperative flap necrosis and seroma formation in patients undergoing a modified radical mastectomy (MRM)...
April 13, 2018: Curēus
https://www.readbyqxmd.com/read/29902907/-external-therapies-of-traditional-chinese-medicine-combined-with-sodium-hyaluronate-injected-in-articular-cavity-therapy-on-knee-osteoarthritis-meta-analysis
#4
Yang-Kai Xu, Fu-Gui Zhu, Er-You Feng, Chao-Ling Fan, Guang-Shu Yu, Yan-Zhen Wei, Li-Hua Xie
To systematically evaluate the efficacy and safety of external therapies of traditional Chinese medicine(TCM) combined with sodium hyaluronate(SH) injected in articular cavity therapy on knee osteoarthritis(KOA). The following databases such as CNKI, WanFang, VIP, CBM, PubMed and Medline were researched to collect the randomized controlled trails on external therapies of TCM combined with sodium hyaluronate injected in articular cavity therapy on KOA. The selection of studies, assessment of methodological quality and data extraction were performed independently by two researchers...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29898677/determinants-of-adherence-and-effects-on-health-related-quality-of-life-after-myocardial-infarction-a-prospective-cohort-study
#5
Gundula Krack, Rolf Holle, Inge Kirchberger, Bernhard Kuch, Ute Amann, Hildegard Seidl
BACKGROUND: Adherence to recommendations and medication is deemed to be important for effectiveness of case management interventions. Thus, reasons for non-adherence and effects on health-related quality of life (HRQoL) should be fully understood. The objective of this research was to identify determinants of non-adherence to medication and recommendations, and to test whether increased adherence improved HRQoL in patients after myocardial infarction (MI) in a case management intervention...
June 7, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29879847/the-sano-study-justification-and-detailed-description-of-a-multidisciplinary-biopsychosocial-rehabilitation-programme-in-patients-with-chronic-low-back-pain
#6
Anne Mette Schmidt, Helle Terkildsen Maindal, Trine Bay Laurberg, Berit Schiøttz-Christensen, Charlotte Ibsen, Kirstine Bak Gulstad, Thomas Maribo
OBJECTIVE: To justify and describe an integrated rehabilitation programme for patients with chronic low back pain prior to evaluation in a randomized controlled trial. METHOD: The Template for Intervention Description and Replication (TIDieR) checklist was used as a structural framework for the description of the integrated rehabilitation programme. As a part of the description, the Medical Research Council guidance, 'Developing and evaluating complex interventions', was used as a framework to justify the integrated rehabilitation programme...
June 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29876247/neuroplasticity-of-cognitive-control-networks-following-cognitive-training-for-chronic-traumatic-brain-injury
#7
Kihwan Han, Sandra B Chapman, Daniel C Krawczyk
Cognitive control is the ability to coordinate thoughts and actions to achieve goals. Cognitive control impairments are one of the most persistent and devastating sequalae of traumatic brain injuries (TBI). There have been efforts to improve cognitive control in individuals with post-acute TBI. Several studies have reported changes in neuropsychological measures suggesting the efficacy of cognitive training in improving cognitive control. Yet, the neural substrates of improved cognitive control after training remains poorly understood...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29873956/cognitive-effects-of-min-101-in-patients-with-schizophrenia-and-negative-symptoms-results-from-a-randomized-controlled-trial
#8
Richard S E Keefe, Philip D Harvey, Anzalee Khan, Jay B Saoud, Corinne Staner, Michael Davidson, Remy Luthringer
OBJECTIVE: Current dopamine-blocking antipsychotic drugs have little impact on the cognitive deficits associated with schizophrenia. We evaluated whether MIN-101, a molecule that combines sigma-2 antagonism and 5-HT2A antagonism, might improve cognitive deficits in individuals with moderate to severe negative symptoms in schizophrenia. METHODS: Individuals (N = 244) aged 18 to 60 years with stable symptoms of DSM-5-defined schizophrenia and moderate to severe negative symptoms were randomized to placebo (n = 83), MIN-101 32 mg (n = 78), or MIN-101 64 mg (n = 83) in a 12-week, phase 2b, prospective, double-blind, placebo-controlled, parallel-group trial between May 2015 and December 2015...
May 15, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29871374/pulsed-radiofrequency-ablation-for-the-treatment-of-glossopharyngeal-neuralgia-secondary-to-oropharyngeal-carcinoma
#9
Neerja Bharti, Suryabrata Chattopadhyay, Navneet Singla, Indu Bala, Yatindra K Batra, Jaimanti Bakshi
BACKGROUND: The management of glossopharyngeal neuralgia due to oropharyngeal carcinoma is particularly difficult because of rich innervations of the area, erosive nature of neoplasm and dynamic pain evoked by the functional movements like swallowing and chewing. Few case reports have shown the efficacy of pulsed radiofrequency (PRF) treatment in primary and secondary glossopharyngeal neuralgia in non-cancer patients. However, the efficacy of PRF ablation of the glossopharyngeal nerve in oral cancer patients is not known...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29867604/effect-of-yoga-based-lifestyle-intervention-on-patients-with-knee-osteoarthritis-a-randomized-controlled-trial
#10
Singh Deepeshwar, Monika Tanwar, Vijaya Kavuri, Rana B Budhi
Objective: To investigate the effect of integrated approach of yoga therapy (IAYT) intervention in individual with knee Osteoarthritis. Design: Randomized controlled clincial trail. Participants: Sixty-six individual prediagnosed with knee osteoarthritis aged between 30 and 75 years were randomized into two groups, i.e., Yoga ( n = 31) and Control ( n = 35). Yoga group received IAYT intervention for 1 week at yoga center of S-VYASA whereas Control group maintained their normal lifestyle. Outcome measures: The Falls Efficacy Scale (FES), Handgrip Strength test (left hand LHGS and right hand RHGS), Timed Up and Go Test (TUG), Sit-to-Stand (STS), and right & left extension and flexion were measured on day 1 and day 7...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29866396/single-site-robotic-cholecystectomy-versus-multi-port-laparoscopic-cholecystectomy-a-systematic-review-and-meta-analysis
#11
Ning Sun, Jialin Zhang, Chengshuo Zhang, Yue Shi
OBJECTIVE: To investigate the outcomes of single-site robotic cholecystectomy (SSRC) compared to multi-port laparoscopic cholecystectomy (MLC), evaluate the safety and feasibility of SSRC. METHODS: To find relevant studies, the electronic databases PubMed, MEDLINE, The Cochrane Library, and EMBASE were used to seek information in English literature from 2011 to 2017. Studies comparing SSRC to MLC, for any indication, were included in the analysis. This systematic review and meta-analysis was performed with RevMan Version 5...
May 22, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29852538/what-is-the-impact-of-professional-learning-on-physical-activity-interventions-among-preschool-children-a-systematic-review
#12
REVIEW
M E Peden, A D Okely, M J Eady, R A Jones
The purpose of this systematic review was to investigate professional learning models (length, mode, content) offered as part of objectively measured physical childcare-based interventions. A systematic review of eight electronic databases was conducted to June 2017. Only English, peer-reviewed studies that evaluated childcare-based physical activity interventions, incorporated professional learning and reported objectively measured physical activity were included. Study designs included randomized controlled trails, cluster randomized trials, experimental or pilot studies...
May 31, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29851819/effects-of-cognitive-motor-dual-task-training-combined-with-auditory-motor-synchronization-training-on-cognitive-functioning-in-individuals-with-chronic-stroke-a-pilot-randomized-controlled-trial
#13
Myoung-Ok Park, Sang-Heon Lee
BACKGROUND: Preservation and enhancement of cognitive function are essential for the restoration of functional abilities and independence following stroke. While cognitive-motor dual-task training (CMDT) has been utilized in rehabilitation settings, many patients with stroke experience impairments in cognitive function that can interfere with dual-task performance. In the present study, we investigated the effects of CMDT combined with auditory motor synchronization training (AMST) utilizing rhythmic cues on cognitive function in patients with stroke...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29847314/the-effects-of-sahaja-yoga-meditation-on-mental-health-a-systematic-review
#14
Tom Hendriks
Objectives To determine the efficacy of Sahaja Yoga (SY) meditation on mental health among clinical and healthy populations. Methods All publications on SY were eligible. Databases were searched up to November 2017, namely PubMed, MEDLINE (NLM), PsychINFO, and Scopus. An internet search (Google Scholar) was also conducted. The quality of the randomized controlled trails was assessed using the Cochrane Risk Assessment for Bias. The quality of cross-sectional studies, a non-randomized controlled trial and a cohort study was assessed with the Newcastle-Ottawa Quality Assessment Scale...
May 30, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29843895/single-versus-double-column-fixation-in-transverse-fractures-of-the-acetabulum-a-randomised-controlled-trial
#15
Mahmoud Fahmy, Mahmoud Abdel Karim, Sherif A Khaled, Ahmed Hazem Abdelazeem, Walid A Elnahal, Ashraf Elnahal
INTRODUCTION: Biomechanical studies have compared fixation methods in transverse acetabular fractures, yet there is not enough clinical data to suggest an optimal fixation method. The aim of this randomized controlled trail was to compare fracture stability in posterior plating alone versus posterior plating and anterior column lag-screw fixation in treatment of transverse and transverse with posterior wall acetabular fractures. METHODS: Thirty patients were randomized to one of two groups, either posterior fixation alone (single column group), or posterior plating and anterior fixation with percutaneous anterior column screw (double column group)...
May 24, 2018: Injury
https://www.readbyqxmd.com/read/29843454/experimental-effects-of-acute-exercise-and-meditation-on-parameters-of-cognitive-function
#16
Meghan K Edwards, Paul D Loprinzi
Single bouts of aerobic exercise and meditation have been shown to improve cognitive function. Yet to be examined in the literature, we sought to examine the effects of a combination of acute bouts of aerobic exercise and meditation on cognitive function among young adults. Participants ( n = 66, mean (SD) age = 21 (2)) were randomly assigned to walk then meditate, meditate then walk, or to sit (inactive control). All walking and meditation bouts were 10 min in duration. Participants' cognition was monitored before and after the intervention using Identification, Set Shifting, Stroop, and Trail Making tasks...
May 29, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29796338/tai-chi-for-reducing-dual-task-gait-variability-a-potential-mediator-of-fall-risk-in-parkinson-s-disease-a-pilot-randomized-controlled-trial
#17
Gloria Vergara-Diaz, Kamila Osypiuk, Jeffrey M Hausdorff, Paolo Bonato, Brian J Gow, Jose Gv Miranda, Lewis R Sudarsky, Daniel Tarsy, Michael D Fox, Paula Gardiner, Cathi A Thomas, Eric A Macklin, Peter M Wayne
Objectives: To assess the feasibility and inform design features of a fully powered randomized controlled trial (RCT) evaluating the effects of Tai Chi (TC) in Parkinson's disease (PD) and to select outcomes most responsive to TC assessed during off-medication states. Design: Two-arm, wait-list controlled RCT. Settings: Tertiary care hospital. Subjects: Thirty-two subjects aged 40-75 diagnosed with idiopathic PD within 10 years...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29782693/multidomain-intervention-for-the-prevention-of-cognitive-decline-after-stroke-a-pooled-patient-level-data-analysis
#18
Yvonne Teuschl, Hege Ihle-Hansen, Karl Matz, Alexandra Dachenhausen, Paulina Ratajczak, Jaakko Tuomilehto, Marie Helene Ursin, Guri Hagberg, Bente Thommessen, Anne Rita Øksengård, Michael Brainin
BACKGROUND: The aim of this pooled patient-level data analysis was to test if multidomain interventions, addressing several modifiable vascular risk factors simultaneously, is more effective than usual post-stroke care for the prevention of cognitive decline after stroke. METHODS: This pooled patient-level data analysis includes two randomised controlled trials using a multidomain approach to target vascular risk factors in stroke patients and cognition as primary outcome...
May 21, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29779485/tgn-1412-and-bia-2474-trials-with-tragic-end-lessons-learnt-to-make-clinical-trials-safer
#19
Rimple Jeet Kaur, Surjit Singh, Preeti Sidhu, Pramod Kumar Sharma
BACKGROUND: Globally, there have been tremendous efforts by regulatory authorities to make clinical trials safer by making stringent clinical trial regulations. Despite this, we witnessed several tragic events. TGN1412 and BIA 10-2474 phase I trials are infamous trails in which healthy volunteers either succumbed to severe adverse effects or faced irreversible impairments of the test drug. Such afflictions in clinical trials are not only turbulent to the image of pharmaceutical industry but it also conveys dispiriting message for clinical trial participants...
May 20, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29779161/empowering-lay-counsellors-with-technology-masivukeni-a-standardized-multimedia-counselling-support-tool-to-deliver-art-counselling
#20
H Gouse, R N Robbins, C A Mellins, A Kingon, J Rowe, M Henry, R H Remien, A Pearson, F Victor, J A Joska
Lay-counsellors in resource-limited settings convey critical HIV- and ART-information, and face challenges including limited training and variable application of counselling. This study explored lay-counsellors and Department of Health (DoH) perspectives on the utility of a multimedia adherence counselling program. Masivukeni, an mHealth application that provides scaffolding for delivering standardized ART counselling was used in a 3-year randomized control trail at two primary health care clinics in Cape Town, South Africa...
May 19, 2018: AIDS and Behavior
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