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Random control trails

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https://www.readbyqxmd.com/read/28731266/a-randomized-double-blind-placebo-controlled-crossover-study-of-the-effects-of-levetiracetam-on-cognition-mood-and-balance-in-healthy-older-adults
#1
Mike R Schoenberg, Ruba S Rum, Katie E Osborn, Mary Ann Werz
OBJECTIVE: The cognitive and mood effects of levetiracetam (LEV) in older adults are not known. This study compared the cognitive and mood effects of LEV to placebo in healthy older adults. METHODS: Cognitive, mood, and balance variables were compared between LEV and placebo using a randomized, double-blind, placebo-controlled crossover study with two 5-week treatment periods. Healthy volunteers (n = 20) aged 65-80 (mean age 72.4) received either LEV or placebo in which the LEV target dose was 1,000 mg/day...
July 21, 2017: Epilepsia
https://www.readbyqxmd.com/read/28726492/does-cognition-specific-computer-training-have-better-clinical-outcomes-than-non-specific-computer-training-a-single-blind-randomized-controlled-trial
#2
Ji-Hyuk Park, Jin-Hyuck Park
OBJECTIVE: The purpose of this study was to investigate differences between non-specific computer training (NCT) and cognition-specific computer training (CCT). DESIGN: Randomized controlled experimental study. SETTING: Local community welfare center. SUBJECTS: A total of 78 subjects with mild cognitive impairment (MCI) were randomly assigned to the NCT ( n = 39) or CCT group ( n = 39). INTERVENTION: The NCT group underwent NCT using Nintendo Wii for improving functional performance, while the CCT group underwent CCT using CoTras for improving function of the cognitive domain specifically...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28697504/effects-of-a-training-program-involving-body-cooling-on-physical-and-cognitive-capacities-and-quality-of-life-in-multiple-sclerosis-patients-a-pilot-study
#3
Benoit Gonzales, Gilles Chopard, Benjamin Charry, Eric Berger, Julien Tripard, Eloi Magnin, Alain Groslambert
OBJECTIVE: Two methods using exercise and body cooling could influence the well-being of patients with multiple sclerosis (PwMS). The aim of this study was to determine whether wearing a cooling vest during a physical training program could increase the cognitive and physical capacities and quality of life in PwMS. METHODS: Eighteen PwMS (49.6 ± 8 years; Expanded Disability Status Score 5.0 ± 1.0) were randomly assigned to a cooling or control group. PwMS underwent a 7-week physical training program...
July 12, 2017: European Neurology
https://www.readbyqxmd.com/read/28682124/motor-cognitive-effects-of-a-computerized-game-based-training-method-in-people-with-dementia-a-randomized-controlled-trial
#4
Stefanie Wiloth, Christian Werner, Nele Christin Lemke, Jürgen Bauer, Klaus Hauer
OBJECTIVES: To examine the effects of a computerized, game-based training on motor-cognitive performances, the transfer of training effects on untrained tasks, and the sustainability of training gains in people with dementia. METHOD: Ninety-nine individuals with a mean age of 82.9 (5.8) and dementia participated in a 10-week randomized controlled trial with three-month follow-up. The intervention group (IG) received a motor-cognitive training on (Physiomat®) including concurrent dual-tasks of balance control with cognitive demands (Physiomat®-Trail Making Tasks (PTMTs))...
July 6, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28681715/motor-cortex-trns-improves-pain-affective-and-cognitive-impairment-in-patients-with-fibromyalgia-preliminary-results-of-a-randomised-sham-controlled-trial
#5
Massimiliano Curatolo, Giuseppe La Bianca, Giuseppe Cosentino, Roberta Baschi, Giuseppe Salemi, Rossella Talotta, Marcello Romano, Giovanni Triolo, Marina De Tommaso, Brigida Fierro, Filippo Brighina
OBJECTIVES: Fibromyalgia (FM) is a clinical syndrome characterised by widespread musculoskeletal pain, chronic fatigue, cognitive deficits, and sleep and mood disorders. The effectiveness of most pharmacological treatments is limited, and there is a need for new, effective and well-tolerated therapies. It has recently been shown that transcranial direct-current stimulation (tDCS) of the motor cortex reduces pain, and that tDCS of the dorso-lateral prefrontal cortex (DLPFC) improves anxiety, depression and cognitive impairment in FM patients...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28678111/effectiveness-and-safety-of-batroxobin-tranexamic-acid-and-a-combination-in-reduction-of-blood-loss-in-lumbar-spinal-fusion-surgery
#6
Roopa Mn, Ajoy Prasad Shetty, Srikanth Reddy Dumpa, Balavenkat Subarmaniam, Rishi Mugesh Kanna, Rajasekeran Shanmuganathan
STUDY DESIGN: A prospective randomized double blind placebo controlled trail OBJECTIVE.: To evaluate and compare the efficacy and safety of Batroxobin (botropase),Tranexamic acid(TXA) and their combination in reduction of perioperative blood loss in lumbar spine single level fusion surgeries. SUMMARY OF BACKGROUND DATA: Spinal surgeries are associated with significant blood loss leading to perioperative anaemia and increased need for allogenic transfusion. TXA competitively inhibits plasmin and batroxobin converts fibrinogen to fibrin and theoretically their combination is synergistic ...
July 3, 2017: Spine
https://www.readbyqxmd.com/read/28659161/associations-between-cerebral-amyloid-and-changes-in-cognitive-function-and-falls-risk-in-subcortical-ischemic-vascular-cognitive-impairment
#7
Elizabeth Dao, John R Best, Ging-Yuek Robin Hsiung, Vesna Sossi, Claudia Jacova, Roger Tam, Teresa Liu-Ambrose
BACKGROUND: To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). METHODS: This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858)...
June 28, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28639097/effect-of-an-internet-based-telehealth-system-on-functional-capacity-and-cognition-in-breast-cancer-survivors-a-secondary-analysis-of-a-randomized-controlled-trial
#8
Noelia Galiano-Castillo, Manuel Arroyo-Morales, Mario Lozano-Lozano, Carolina Fernández-Lao, Lydia Martín-Martín, Rosario Del-Moral-Ávila, Irene Cantarero-Villanueva
PURPOSE: This trial determines the effect of an Internet-based tailored exercise program compared to usual care control for improving functional capacity and cognition among breast cancer survivors. METHODS: A two-arm, assessor-blinded, parallel, randomized controlled efficacy trial was conducted. Participants were recruited from the Oncology and Breast unit at the Virgen de las Nieves Hospital (Granada, Spain) between March 2012 to November 2013 and randomized to either the experimental group (an 8-week Internet-based tailored exercise program) or control group (usual care)...
June 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28614953/forced-air-warming-for-rewarming-and-comfort-following-laparoscopy-a-randomized-controlled-trail
#9
Hsiao-Chi Nieh, Shu-Fen Su
We investigated the efficacy of a forced-air warming (FAW) system on postoperative rewarming and comfort in patients undergoing laparoscopic surgery. In this randomized controlled trial, a total of 127 participants were randomly divided into the FAW group ( n = 64) and control group ( n = 63). The esophageal temperature was measured every 30 min during surgery, and the tympanic temperature and comfort levels were measured preoperatively and in the postanesthesia care unit (PACU). Data analysis used the generalized estimating equation...
June 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28596746/a-systematic-review-of-psychosocial-interventions-to-cancer-caregivers
#10
REVIEW
Fang Fu, Huaijuan Zhao, Feng Tong, Iris Chi
Objective: To systematically review the effect of psychosocial interventions on improving QoL, depression and anxiety of cancer caregivers. Methods: We conducted a systematic review of psychosocial interventions among adult cancer caregivers published from 2011 to 2016. PsycINFO, PubMed, Proquest, Cochrane Library, Embase, Applied Social Sciences Index and Abstracts (ASSIA), Cumulative Index to Nursing and Allied Health Literature, Social Sciences Citation Index (SSCI) and EBSCO, China National Knowledge Infrastructure (CNKI) and WANFANG were searched...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28587493/a-randomized-controlled-trail-of-a-new-treatment-for-labor-dystocia
#11
Eva Wiberg-Itzel, Susan Wray, Helena Åkerud
OBJECTIVE: Labor dystocia is an intransigent, high-profile issue in obstetric care. Amniotic fluid lactate (AFL) reflects the uterine metabolic status. High levels associate with subsequent need for operative intervention due to dystocia. In sports medicine it is known that lactic acid can affect muscular performance and can be decreased by bicarbonate given orally before physical activity. MATERIAL AND METHODS: Two hundred dystocic deliveries were included. At the confirmation of dystocia, the AFL- level was analyzed...
June 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28585508/-activity-trails-in-the-therapy-of-clinical-depression-a-randomized-controlled-equivalence-trial
#12
Daniel Niederer, Lutz Vogt, Volker Staschke, Catharina Maulbecker-Armstrong, Volker Beck, Winfried Banzer
No abstract text is available yet for this article.
June 2017: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/28558443/effects-of-different-durations-of-aerobic-exercise-intervention-on-the-cardiovascular-health-in-untrained-women-a-meta-analysis-and-meta-regression
#13
Yahui Zhang, Lisheng Xu, Xiaodong Zhang, Yang Yao, Yingxian Sun, Lin Qi
INTRODUCTION: Women's cardiovascular health is a hot topic. Exercise intervention is an effective method to improve the cardiovascular functions. The aim of this study was to systematically assess effects of aerobic exercise at different durations on the cardiovascular health of untrained women. EVIDENCE ACQUISITION: Published articles from January 1989 to March 2016 were identified using electronic databases (PubMed, Cochrane Library, Embase and Web of Science) for randomized controlled trails...
May 30, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28545073/the-clinical-efficacy-and-safety-evaluation-of-ticagrelor-for-acute-coronary-syndrome-in-general-acs-patients-and-diabetic-patients-a-systematic-review-and-meta-analysis
#14
Qiutong Tan, Xin Jiang, Sichao Huang, Tiantian Zhang, Lin Chen, Siwen Xie, Enpan Mo, Jun Xu, Shaohui Cai
OBJECTIVE: In this study, a systematic evaluation was conducted to estimate the efficacy and safety of ticagrelor for treating acute coronary syndrome (ACS) in general ACS patients and a diabetes mellitus (DM) group. METHODS: A search of PubMed, Cochrane Central Register of Controlled Trials, Web of Science, CNKI databases was conducted to analyze relevant randomized controlled trails (RCTs) of ticagrelor treating ACS during 2007 to 2015. Article screening, quality accessing and data extracting was independently undertaken by two reviewers...
2017: PloS One
https://www.readbyqxmd.com/read/28543994/cognitive-enhancing-effects-of-rtms-administered-to-the-prefrontal-cortex-in-patients-with-depression-a-systematic-review-and-meta-analysis-of-individual-task-effects
#15
REVIEW
Donel M Martin, Shawn M McClintock, Jane J Forster, Tin Yan Lo, Colleen K Loo
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an approved therapeutic treatment of major depressive disorder and has increasing clinical use throughout the world. However, it remains unclear whether an rTMS course for depression may also produce cognitive enhancement. In a recent meta-analysis of sham-controlled randomized controlled studies (RCTs) conducted in patients with neuropsychiatric conditions, no evidence was found for generalized cognitive enhancing effects across cognitive domains with active compared to sham rTMS...
May 24, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28511288/a-tele-health-follow-up-strategy-for-tight-control-of-disease-activity-in-rheumatoid-arthritis-results-of-the-non-inferiority-randomised-controlled-trail-the-tera-study
#16
Annette Thurah, Kristian Stengaard-Pedersen, Mette Axelsen, Ulrich Fredberg, Liv M V Schougaard, Niels H I Hjollund, Mogens Pfeiffer-Jensen, Trine B Laurberg, Ulrik Tarp, Kirsten Lomborg, Thomas Maribo
OBJECTIVE: To test the effect of patient-reported outcome (PRO) based tele-health follow-up for tight control of disease activity in patients with rheumatoid arthritis (RA), and the differences between tele-health follow-up performed by rheumatologists or rheumatology nurses. METHODS: A total of 294 patients were randomized (1:1:1) to either PRO-based tele-health follow-up carried out by a nurse (PRO-TN) or a rheumatologist (PRO-TR), or conventional out-patient follow-up by physicians...
May 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28502461/meta-analysis-of-effects-of-voluntary-slow-breathing-exercises-for-control-of-heart-rate-and-blood-pressure-in-patients-with-cardiovascular-diseases
#17
Yan Zou, Xin Zhao, Yun-Ying Hou, Ting Liu, Qing Wu, Yu-Hui Huang, Xiao-Hua Wang
Rising heart rate (HR) and elevated blood pressure (BP) cause a greater frequency of cardiovascular events. Many patients cannot maintain target HR and BP using pharmacological therapies. To evaluate the effectiveness of voluntary slow breathing exercises in reducing resting HR and BP, we searched Embase (1974 to April 2016), PubMed (1966 to April 2016), the Cochrane Central Register of Controlled Trials (issue 4, April 2016), and PEDro (www.pedro.org.au; 1999 to April 2016). The primary outcome was the mean change in HR at rest...
July 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28500554/circularly-permuted-trail-plus-thalidomide-and-dexamethasone-versus-thalidomide-and-dexamethasone-for-relapsed-refractory-multiple-myeloma-a-phase-2-study
#18
RANDOMIZED CONTROLLED TRIAL
Yun Leng, Jian Hou, Jie Jin, Mei Zhang, Xiaoyan Ke, Bin Jiang, Ling Pan, Linhua Yang, Fang Zhou, Jianmin Wang, Zhao Wang, Li Liu, Wei Li, Zhixiang Shen, Lugui Qiu, Naibai Chang, Jianyong Li, Jing Liu, Hongyan Pang, Haitao Meng, Peng Wei, Hua Jiang, Yan Liu, Xiangjun Zheng, Shifang Yang, Wenming Chen
PURPOSE: Circularly permuted TRAIL (CPT) has exhibited promising efficacy as a mono-therapy or in combination with thalidomide for patients with multiple myeloma (MM). In this phase 2 study, the safety and efficacy of CPT in combination with thalidomide and dexamethasone (CPT + TD) was evaluated in patients with pretreated relapsed/refractory MM (RRMM). METHODS: Patients who received at least two previous therapies for MM were randomly assigned at a 2:1 ratio to receive treatment with CPT + TD or thalidomide and dexamethasone (TD)...
June 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28496411/calf-compression-sleeves-change-biomechanics-but-not-performance-and-physiological-responses-in-trail-running
#19
Hugo A Kerhervé, Pierre Samozino, Fabrice Descombe, Matthieu Pinay, Guillaume Y Millet, Marion Pasqualini, Thomas Rupp
Introduction: The aim of this study was to determine whether calf compression sleeves (CS) affects physiological and biomechanical parameters, exercise performance, and perceived sensations of muscle fatigue, pain and soreness during prolonged (~2 h 30 min) outdoor trail running. Methods: Fourteen healthy trained males took part in a randomized, cross-over study consisting in two identical 24-km trail running sessions (each including one bout of running at constant rate on moderately flat terrain, and one period of all-out running on hilly terrain) wearing either degressive CS (23 ± 2 mmHg) or control sleeves (CON, <4 mmHg)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28482405/-efficacy-and-safety-of-pegylated-interferon-%C3%AE-2b-injection-y-shape-40-kd-in-treatment-of-patients-with-genotype-1-6-chronic-hepatitis-c
#20
B Feng, J Shang, S H Wu, H Chen, Y Han, Y Q Li, D Z Zhang, L F Zhao, S F Wei, Q Mao, C B Yin, T Han, M R Wang, S J Chen, J Li, Q Xie, Z Zhen, Z L Gao, Y X Zhang, G Z Gong, D L Yang, C Pan, J F Sheng, H Tang, Q Ning, G F Shi, J Q Niu, G H Luo, Y T Sun, H You, G Q Wang, L L Zhang, J Peng, Q Zhang, J J Liu, C W Chen, X Y Chen, W Zhao, R H Wang, L Sun, L Wei
Objective: To investigate the efficacy and safety of the new investigational drug pegylated interferon α-2b (Peg-IFN-α-2b) (Y shape, 40 kD) injection (180 µg/week) combined with ribavirin in the treatment of patients with genotype 1/6 chronic hepatitis C (CHC), with standard-dose Peg-IFN-α-2a combined with ribavirin as a positive control. Methods: A multicenter, randomized, open-label, and positive-controlled phase III clinical trial was performed. Eligible patients with genotype 1/6 CHC were screened out and randomly divided into Peg-IFN-α-2b(Y shape, 40kD) group and Peg-IFN-α-2a group at a ratio of 2:1...
March 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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