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Random control trails

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https://www.readbyqxmd.com/read/29211397/efficacy-of-targeted-therapy-for-advanced-renal-cell-carcinoma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Chao Wei, Shen Wang, Zhangqun Ye, Zhiqiang Chen
We conducted a systematic review and meta-analysis of the literature on the efficacy of the targeted therapies in the treatment of advanced RCC and, via an indirect comparison, to provide an optimal treatment among these agents. A systematic search of Medline, Scopus, Cochrane Library and Clinical Trials unpublished was performed up to Jan 1, 2015 to identify eligible randomized trials. Outcomes of interest assessing a targeted agent included progression free survival (PFS), overall survival (OS) and objective response rate (ORR)...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29168036/the-gut-microbiome-symptoms-and-targeted-interventions-in-children-with-cancer-a-systematic-review
#2
REVIEW
Jinbing Bai, Madhusmita Behera, Deborah Watkins Bruner
PURPOSE: The gut microbiome plays a critical role in maintaining children's health and in preventing and treating children's disease. Current application of the gut microbiome in childhood cancer is still lacking. This study aimed to systematically review the following: (1) alternations in the gut microbiome throughout cancer treatment trajectories in children, (2) the associations between the gut microbiome and gastrointestinal (GI) symptoms and psychoneurological symptoms (PNS), and (3) the efficacy of therapeutic interventions in the gut microbiome in children with cancer...
November 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29159267/long-term-impact-of-intensive-lifestyle-intervention-on-cognitive-function-assessed-with-the-national-institutes-of-health-toolbox-the-look-ahead-study
#3
Kathleen M Hayden, Laura D Baker, George Bray, Raymond Carvajal, Kathryn Demos-McDermott, Andrea L Hergenroeder, James O Hill, Edward Horton, John M Jakicic, Karen C Johnson, Rebecca H Neiberg, Stephen R Rapp, Thomas A Wadden, Michael E Miller
Introduction: This study sought to determine whether 10 years of assignment to intensive lifestyle intervention (ILI) relative to diabetes support and education leads to better cognition. We examine intervention effects overall and among clinical subgroups, and report correlations between computer-administered and interviewer-administered cognitive batteries. Methods: The Action for Health in Diabetes (Look AHEAD) was a 16-site randomized controlled trial with overweight/obese individuals (aged 45-76) who had type 2 diabetes...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29141357/-prevention-for-glucocorticoid-induced-osteonecrosis-of-femoral-head-a-long-term-clinical-follow-up-trail
#4
B Y Liu, L Yang, B J Wang, Z H Wang, L L Cheng, H Xie, X Qiu, Z J Ma, D W Zhao
Objective: To evaluated the outcome of prevention and treatment for glucocorticoid-induced osteonecrosis of femoral head with anticoagulant and vasodilator drugs. Methods: A prospective, randomized, double-blind study was performed. From August 2003 to August 2006, 58 patients with large amounts of hormone therapy in the Zhongshan Hospital Affiliated Dalian University were enrolled and randomly assigned to the control group (placebo) or preventive group (anticoagulant and vasodilator drugs). And we prospectively analyzed the clinical outcomes of 24 patients with glucocorticoid-induced osteonecrosis of femoral head early stage (treatment group)treated by anticoagulant and vasodilator drugsat the same time...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29138012/systematic-review-on-reporting-quality-of-randomized-controlled-trials-in-patients-with-hepatitis-b-or-c-in-china
#5
Na Zeng, Cailun Zou, Zhiying He, Hong Ma, Xiaojuan Ou, Hong You, Yuanyuan Kong, Jidong Jia
BACKGROUND: Randomized controlled trails (RCTs) on viral hepatitis in China have been increasing, but few studies have been systematically conducted to evaluate the reporting quality of RCTs in this field. In the present study, we assessed the reporting quality of RCTs on the treatment of hepatitis B or C from 1991 to 2015 in China. METHODS: Articles published between January 1991 and December 2015 were identified via PubMed, Medline, and Embase by using the key words "randomized clinical trials," "treatment," "therapy," "hepatitis B," "HBV," "hepatitis C," "HCV," "China," and "Chinese...
November 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29131814/effects-of-an-exercise-protocol-for-improving-handgrip-strength-and-walking-speed-on-cognitive-function-in-patients-with-chronic-stroke
#6
Jaeeun Kim, Jongeun Yim
BACKGROUND Handgrip strength and walking speed predict and influence cognitive function. We aimed to investigate an exercise protocol for improving handgrip strength and walking speed, applied to patients with chronic stroke who had cognitive function disorder. MATERIAL AND METHODS Twenty-nine patients with cognitive function disorder participated in this study, and were randomly divided into one of two groups: exercise group (n=14) and control group (n=15). Both groups underwent conventional physical therapy for 60 minutes per day...
November 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29089888/effect-of-speed-of-processing-training-on-older-driver-screening-measures
#7
Ranmalee Eramudugolla, Kim M Kiely, Sidhant Chopra, Kaarin J Anstey
Objective: Computerized training for cognitive enhancement is of great public interest, however, there is inconsistent evidence for the transfer of training gains to every day activity. Several large trials have focused on speed of processing (SOP) training with some promising findings for long-term effects on daily activity, but no immediate transfer to other cognitive tests. Here, we examine the transfer of SOP training gains to cognitive measures that are known predictors of driving safety in older adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29063516/paroxetine-and-fluconazole-therapy-for-hiv-associated-neurocognitive-impairment-results-from-a-double-blind-placebo-controlled-trial
#8
Ned Sacktor, Richard L Skolasky, Richard Moxley, Sheng Wang, Michelle M Mielke, Cynthia Munro, Joseph Steiner, Avindra Nath, Norman Haughey, Justin McArthur
Paroxetine and fluconazole have neuroprotective effects in an in vitro model of HIV protein-mediated neuronal injury. This study evaluated the safety, tolerability, and efficacy of both paroxetine and fluconazole for the treatment of HIV-associated neurocognitive disorder (HAND). A 24-week randomized double-blind, placebo-controlled 2 × 2 factorial design study was used. HIV+ individuals with cognitive impairment were enrolled in the 24-week trial. Participants were randomly assigned to one of four groups: (1) paroxetine 20 mg/day, (2) fluconazole 100 mg every 12 h, (3) paroxetine and fluconazole, or (4) placebo...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29059289/bonded-versus-vacuum-formed-retainers-a-randomized-controlled-trial-part-1-stability-retainer-survival-and-patient-satisfaction-outcomes-after-12-months
#9
Katherine Forde, Madeleine Storey, Simon J Littlewood, Paul Scott, Friedy Luther, Jing Kang
Background: There is a shortage of evidence on the best type of retainer. Objectives: Evaluate upper and lower bonded retainers (BRs) versus upper and lower vacuum-formed retainers (VFRs) over 12 months, in terms of stability, retainer survival, and patient satisfaction. Trial design: Two-arm parallel group multi-centre randomized controlled clinical trial. Methods: Sixty consecutive patients completing fixed appliance therapy and requiring retainers were recruited from 3 hospital departments...
October 20, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29052663/self-management-intervention-for-adult-cancer-survivors-after-treatment-a-systematic-review-and-meta-analysis
#10
Soo Hyun Kim, Kisook Kim, Deborah K Mayer
PROBLEM IDENTIFICATION: This study aims to evaluate the effects of self-management interventions (SMIs) for cancer survivors who completed primary treatment. 
. LITERATURE SEARCH: Using PubMed, EMBASE, CINAHL®, PsycINFO®, and Cochrane Central Register of Controlled Trails (CENTRAL), the authors conducted a systematic search of randomized, controlled trials published in English from database conception through June 2016. 
. DATA EVALUATION: The meta-analysis was conducted with Cochrane Review Manager, version 5...
November 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29045478/camera-trap-placement-and-the-potential-for-bias-due-to-trails-and-other-features
#11
Joseph M Kolowski, Tavis D Forrester
Camera trapping has become an increasingly widespread tool for wildlife ecologists, with large numbers of studies relying on photo capture rates or presence/absence information. It is increasingly clear that camera placement can directly impact this kind of data, yet these biases are poorly understood. We used a paired camera design to investigate the effect of small-scale habitat features on species richness estimates, and capture rate and detection probability of several mammal species in the Shenandoah Valley of Virginia, USA...
2017: PloS One
https://www.readbyqxmd.com/read/29036816/sex-difference-in-aerobic-exercise-efficacy-to-improve-cognition-in-older-adults-with-vascular-cognitive-impairment-secondary-analysis-of-a-randomized-controlled-trial
#12
Cindy K Barha, Ging-Yuek R Hsiung, John R Best, Jennifer C Davis, Janice J Eng, Claudia Jacova, Philip E Lee, Michelle Munkacsy, Winnie Cheung, Teresa Liu-Ambrose
Aerobic training (AT) is a promising, non-pharmacological intervention to mitigate the deleterious effects of aging and disease on brain health. However, a large amount of variation exists in its efficacy. This is a secondary analysis of a randomized controlled trial of AT in 71 older adults with subcortical ischemic vascular cognitive impairment (NCT01027858). Specifically, we investigated: 1) whether sex moderates the relationship between AT and executive functions, and 2) the role of brain derived neurotrophic factor (BDNF) and gains in functional fitness capacity...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29027351/robotic-assisted-versus-open-radical-cystectomy-in-bladder-cancer-a-meta-analysis-of-four-randomized-controlled-trails
#13
Jin-Qiu Tang, Zhihong Zhao, Yiwen Liang, Guixiang Liao
BACKGROUND: Robot-assisted radical cystectomy (RARC) is increasing annually for treatment of bladder cancer. The objective of this meta-analysis was to compare the safety and efficacy of RARC and open radical cystectomy (ORC) for bladder cancer. METHODS: Our meta-analysis searches were conducted using PubMed, Web of Science, and Cochrane Library databases to identify randomized controlled trials (RCT) assessing the two techniques. RESULTS: Four RCT studies were identified, including 239 cases...
October 12, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29026977/mesh-versus-patch-repair-for-epigastric-and-umbilical-hernia-morpheus-trial-one-year-results-of-a-randomized-controlled-trial
#14
J E H Ponten, B J M Leenders, W K G Leclercq, T Lettinga, J Heemskerk, J L M Konsten, P S S Castelijns, S W Nienhuijs
DESIGN: This trial is a randomized controlled, patient-blinded, multicentre, superiority trial. METHODS: All patients ≥18 years with a single, symptomatic and primary umbilical or epigastric hernia (<2 fingers) qualified for participation in the study. Flat polypropylene mesh repair was compared to patch repair (PROCEED(®) Ventral Patch) (PVP). The objective of this trial was to identify a superior method for umbilical and epigastric hernia repair in terms of complication rates...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29019011/a-systematic-review-and-meta-analysis-of-mechanical-vs-biological-composite-aortic-root-replacement-early-and-1-year-results
#15
Mohamad Bashir, Amer Harky, Saied Froghi, Benjamin Adams, Megan Garner, Prity Gupta, Aung Oo, Rakesh Uppal
OBJECTIVE: Composite aortic root replacement is a standard procedure for various aortic root pathologies. This systematic review was set to identify the postoperative outcomes for composite mechanical root replacement (mCRR) compared to composite biological root replacement (bCRR). METHODS: We systematically reviewed four major databases for all papers assessing outcomes in composite root replacement. Articles selected were chosen by two reviewers. Amongst our inclusion and exclusion criteria, all pediatric populations were excluded as were studies with a cohort less than 50 patients...
October 10, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28975468/effect-of-restricted-protein-diet-supplemented-with-keto-analogues-in-end-stage-renal-disease-a-systematic-review-and-meta-analysis
#16
REVIEW
Zheng Jiang, Yi Tang, Lichuan Yang, Xuhua Mi, Wei Qin
AIM: To evaluate the efficacy and safety of the restricted protein diet supplemented with keto analogues when applied in end-stage renal disease (ESRD). METHODS: The Cochrane Library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to January 2017. Clinical trials were analyzed using RevMan 5.3 software. RESULTS: Five randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria...
October 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28972265/efficacy-of-a-web-based-intervention-for-concerned-spouses-of-service-members-and-veterans-with-alcohol-misuse
#17
Karen Chan Osilla, Thomas E Trail, Eric R Pedersen, Kristie L Gore, Anagha Tolpadi, Lindsey M Rodriguez
Concerned partners (CPs) of service members and veterans who misuse alcohol face help-seeking barriers and mental health problems. We used multiple regression to evaluate the efficacy of Partners Connect, a four-session web-based intervention (WBI) to address military CPs' mental health and communication. We randomized 312 CPs to the WBI or a control group. Five months later, WBI CPs reported significant reductions in their anxiety and increases in their social support compared to control CPs. Intervention dose was also associated with improved WBI CP outcomes...
October 3, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28953626/comparison-of-liposomal-bupivacaine-infiltration-versus-interscalene-nerve-block-for-pain-control-in-total-shoulder-arthroplasty-a-meta-analysis-of-randomized-control-trails
#18
REVIEW
Xiuling Cao, Fang Pan
BACKGROUND: This meta-analysis aimed to compare the efficiency and safety of liposomal bupivacaine infiltration and interscalene nerve block for pain control after total shoulder arthroplasty. METHODS: A systematic search was performed in Medline (1966 to May 2017), PubMed (1966 to May 2017), Embase (1980 to May 2017), ScienceDirect (1985 to May 2017) and the Cochrane Library. Only randomized controlled trials (RCTs) were included. Reported surgical outcomes, including visual analogue scale (VAS) scores, opioid consumption, length of stay, and postoperative adverse effects including the risk of nausea and vomiting...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28951111/registry-based-randomized-controlled-trials-merged-the-strength-of%C3%A2-randomized-controlled-trails-and-observational-studies-and-give-rise%C3%A2-to%C3%A2-more-pragmatic-trials
#19
Tim Mathes, Stefanie Buehn, Peggy Prengel, Dawid Pieper
OBJECTIVES: The objective of this study was to analyze the features of registry-based randomized trials (rRCTs). STUDY DESIGN AND SETTING: We systematically searched PubMed for rRCTs. Study selection was performed independently by two reviewers. We extracted all data in standardized tables and prepared descriptive summary statistics. RESULTS: The search resulted in 1,202 hits. We included 71 rRCTs. Most rRCTs were from Denmark and Sweden. Chronic conditions were considered in 82...
September 22, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28932989/predictors-of-response-to-glucagon-like-peptide-1-receptor-agonists-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#20
Matteo Monami, Ilaria Dicembrini, Besmir Nreu, Francesco Andreozzi, Giorgio Sesti, Edoardo Mannucci
AIMS: The aim of the present meta-analysis is the identification of the characteristics of patients, which predict the efficacy on HbA1c of glucagon-like peptide-1 receptor agonists (GLP-1 RA). METHODS: A Medline and Embase search for "exenatide" OR "liraglutide" OR "albiglutide" OR "dulaglutide" OR "lixisenatide" was performed, collecting randomized clinical trials (duration > 12 weeks) up to September 2016, comparing GLP-1 RA at the maximal approved dose with placebo or active drugs...
December 2017: Acta Diabetologica
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