Shinichi Nogi, Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Kota Shimada, Takanori Azuma, Takao Sugiyama, Fuminori Hirano, Akira Okamoto, Misuzu Fujimori, Yoshiro Horai, Atsushi Ihata, Atsushi Hashimoto, Akiko Komiya, Toshihiro Matsui, Naoshi Fukui, Masao Katayama, Kiyoshi Migita, Shigeto Tohma
OBJECTIVE: The hallmarks of the chronic inflammatory disease polymyalgia rheumatica (PMR) include pain, and morning stiffness in areas of the neck, shoulder and pelvic girdle. The human leucocyte antigen ( HLA ) gene was reported to be an important risk factor for PMR, but it has not been analysed precisely, especially in populations other than Europeans. METHODS: Genotyping of DRB1 and DQB1 was performed in Japanese PMR patients (n=270) and controls (n=413). Associations between allele carrier and genotype frequencies were determined for PMR...
January 22, 2024: RMD Open